An active composition for reducing dandruff

Abstract

The present invention relates to an active composition for reducing dandruff. The active composition comprises the following components: dichlorobenzyl alcohol, 0.5% to 1%; modified salicylic acid component, 10% to 40%; olive leaf extract, 1% to 10%; glycolipid solubilizer, 3% to 10%; polyol or pure water as a solvent, 50% to 80%. The active composition for reducing dandruff obtained according to the present invention has achieved relatively excellent comprehensive anti-dandruff, anti-inflammatory, and long-lasting antibacterial effects under the condition of improved use experience.

Description

Technical Field

[0001] The present invention relates to the field of personal care, specifically to hair cleaning products, and more specifically, the present invention relates to an active composition for reducing dandruff, and a preparation method of such an active composition. Background Art

[0002] In the field of hair care, in addition to normal cleaning needs, people generally pursue healthy and smooth hair quality and hope to maintain a hair quality level with excellent physical sensations for a long time. In this regard, dandruff is a common problem, and a large number of people globally are troubled by dandruff at a certain stage of their lives. Medically, some studies have defined dandruff as a series of skin rash diseases, such as defining it as pityriasis capitis, also known as pityriasis simplex capitis. Dandruff is caused by excessive sebum secretion due to overstimulation of the sebaceous gland secretion function, manifested as thin flakes of dandruff falling off the scalp, which can be dry or have an oily characteristic. Depending on the severity of dandruff, mild dandruff is similar to the flakes of dry skin, generally appearing as scattered white dots in appearance, and severe dandruff can also lead to skin diseases such as seborrheic dermatitis.

[0003] A large number of scientific studies have been involved in removing dandruff while cleaning the scalp and hair. For example, Chinese Patent Publication CN113599286A relates to a method for resisting dandruff and its composition. In the technical solution disclosed in this research, it involves a method and use for conditioning the scalp to resist the onset, recurrence, or exacerbation of symptoms related to dandruff, including applying glycerol or a composition containing glycerol to an individual's scalp. In such research solutions, it involves using glycerol as a solvent to prepare a composition for resisting dandruff, which focuses on the hydrophilic or lipophilic characteristics of the composition. However, in such research, there is no special attention paid to the continuous effectiveness of anti-dandruff after using hair care products, nor is there attention paid to the improvement of the scalp and the user's physical sensations by hair care products. Summary of the Invention

[0004] Based on the above related technologies, the present invention provides a technical solution to solve one or more deficiencies in the above related prior arts. According to the solution of the present invention, a modified salicylic acid component is used in combination with other antibacterial and anti-inflammatory components, while improving and regulating the continuous antibacterial property and sustained-release performance of the salicylic acid component, so that while the composite improvement structure exerts the anti-inflammatory effect of salicylic acid itself, it also assists the anti-dandruff fungal effect of other components. At the same time, it alleviates the excessive adhesiveness and unclean washing feeling of the composition brought about when using gum arabic to modify salicylic acid alone. Under the condition of improved use experience, more excellent comprehensive dandruff removal, anti-inflammatory, and long-lasting antibacterial effects are achieved.

[0005] The first aspect of the present invention provides an active composition for reducing dandruff, comprising the following components, calculated by mass percentage: dichlorobenzyl alcohol, 0.5% to 1%; a modified salicylic acid component, 10% to 40%; an olive leaf extract (oleuropein), 1% to 10%; a glycolipid solubilizer, 3% to 10%; and a polyol or purified water, 50% to 80%. The polyol or purified water can be used as a solvent, and the polyol can be isopentyl glycol, 1,2-hexanediol, and / or butylene glycol.

[0006] In an optional technical solution, the modified salicylic acid component is prepared by first modifying salicylic acid with bentonite and then with gum arabic.

[0007] In a further preferred technical solution, the modified salicylic acid component is prepared by the following process: preparing raw materials salicylic acid, surfactant component, 3-methyl-1,3-butanediol (isopentyl glycol), bentonite, and anhydrous ethanol, wherein salicylic acid accounts for 55% to 60% of the total mass of the above raw materials, and bentonite accounts for 5 to 10% of the total mass of the above raw materials; fully stirring and mixing salicylic acid and anhydrous ethanol, and then adding the surfactant component and 3-methyl-1,3-butanediol in sequence and stirring and mixing; heating the above mixture and continuously stirring to obtain a white uniform mixture; spraying the white uniform mixture in a spray dryer The steps of drying the mixture to obtain a dry salicylic acid mixture powder are performed; the bentonite with the salicylic acid mixture powder is mixed and dry-ground in a solid ball mill to obtain salicylic acid bentonite modified powder; the salicylic acid bentonite modified powder is then placed in a container, 20 to 30 grams of gum arabic is added per 100 grams of salicylic acid bentonite modified powder, and purified water is added at a gum arabic to purified water mass ratio of 1:(1-1.5), followed by stirring so that the gum arabic is fully coated with the salicylic acid bentonite modified powder again; and the solution mixture is spray-dried again to obtain a final modified salicylic acid component.

[0008] According to the previous technical solution, further optionally, the modified salicylic acid component is prepared by the following specific process:

[0009] Weigh the raw materials of the following components according to the mass ratio, where salicylic acid is 55%-60%; polyquaternium-61 as the surface active component is 10%-15%, 3-methyl-1,3-butanediol is 5%-10%, and bentonite is 5-10%; the balance of the above composition is made up to 100% by mass with absolute ethanol; fully stir and mix salicylic acid and absolute ethanol, and then successively add polyquaternium-61 and 3-methyl-1,3-butanediol and fully stir and mix; put the above mixed solution into a hot water bath heating container, control the heating temperature at 65-70°C, and control the stirring device at 500-600 revolutions per minute and fully stir for 30-45 minutes to obtain a white homogeneous mixture; spray-dry the white homogeneous mixture into powder in a spray dryer, where the spray-drying process controls the feed temperature at 60°C, the hot air inlet temperature at 100°C, the feed flow rate at 2 liters per hour to 2.5 liters per hour, and remove the solvent ethanol to obtain a dry salicylic acid-containing mixture powder; then, mix the weighed content of bentonite with the salicylic acid-containing mixture powder, put it into a solid ball mill for dry grinding, control the rotation speed at 600-800 rpm, the ball milling time at 2 to 3 hours, and the ball-to-material ratio at (3-5):1 to obtain a modified salicylic acid-bentonite powder; next, put the modified salicylic acid-bentonite powder into a heatable stirring container, add gum arabic according to the ratio of 20-30 grams per 100 grams of the modified salicylic acid-bentonite powder, add pure water according to the mass ratio of gum arabic: pure water of 1:(1-1.5), and stir at a speed of 150-250 rpm to make the gum arabic fully wrap the modified salicylic acid-bentonite powder again, and stir continuously for 15-30 minutes. After that, spray-dry the solution mixture again, where the spray-drying process controls the feed temperature at 50°C, the hot air inlet temperature at 90-95°C, the feed flow rate at 2 to 2.5 liters per hour, and the discharge temperature at 60-80°C to obtain the final modified salicylic acid component.

[0010] In a preferred technical solution of the present invention, the active composition has the following components by mass percentage: dichlorobenzyl alcohol, 0.5% to 1%; modified salicylic acid component, 10% to 35%, preferably 15% to 30%; olive leaf extract, 1% to 10%, preferably 1% to 15%; glycolipid solubilizer, 5% to 10%, preferably the solubilizer is selected from rhamnolipid and / or sophorolipid; and isopentyl glycol, 50% to 80%.

[0011] The second aspect of the present invention provides a method for preparing an active composition for reducing dandruff, and the method includes the following steps:

[0012] Step 1, Preparation of the modified salicylic acid component: Prepare raw materials including salicylic acid, surface active component, 3-methyl-1,3-butanediol, bentonite, and absolute ethanol, where salicylic acid accounts for 55% to 60% of the total mass of the above raw materials, and bentonite accounts for 5 to 10% of the total mass of the above raw materials; fully stir and mix salicylic acid and absolute ethanol, then sequentially add the surface active component and 3-methyl-1,3-butanediol and fully stir and mix; heat the above mixture and continuously stir to obtain a white homogeneous mixture; spray-dry the white homogeneous mixture in a spray dryer to obtain a dried powder of the salicylic acid mixture; mix the above content of bentonite with the powder of the salicylic acid mixture, and perform dry grinding in a solid ball mill to obtain a modified powder of salicylic acid bentonite; and place the modified powder of salicylic acid bentonite in a container, add gum arabic according to the ratio of 20 - 30 grams of gum arabic per 100 grams of the modified powder of salicylic acid bentonite, add pure water according to the mass ratio of gum arabic:pure water of 1:(1 - 1.5), and then stir to make the gum arabic fully wrap the modified powder of salicylic acid bentonite again; thereafter, spray-dry the solution mixture again to obtain the final modified salicylic acid component;

[0013] Step 2, Prepare the anti-dandruff active composition using the final modified salicylic acid component. Calculated by mass percentage, the active composition includes the following components: dichlorobenzyl alcohol, 0.5% to 1%; the final modified salicylic acid component, 10% to 40%; olea europaea leaf extract (oleuropein), 1% to 10%; solubilizer, 3 to 10%; polyol or pure water, 50 to 80%; mix and stir the above components in a container to obtain the anti-dandruff active composition.

[0014] According to the optional technical solution, the anti-dandruff active composition includes the following components: dichlorobenzyl alcohol, 0.5% to 1%; the final modified salicylic acid component, 10% to 35%, preferably 15% to 30%; olea europaea leaf extract, 1% to 10%, preferably 1% to 15%; glycolipid solubilizer, 5% to 10%, preferably the solubilizer is selected from rhamnolipid and / or sophorolipid; and isopentyl glycol, 1,2-hexanediol or butanediol, 50% to 80%.

[0015] In the technical solution of the present invention, the composition may only contain the above main components and does not contain other main or minor components, that is, the composition of the present invention may consist only of the above components. However, in the optional technical solution, in addition to the above components, the composition of the present invention may also include other components, such as odor regulators, surfactants, etc., which can be appropriately added based on the fully disclosed solution of the present invention.

[0016] Beneficial effects

[0017] According to the solution of the present invention, a modified salicylic acid component is used in combination with other antibacterial and anti-inflammatory components, which simultaneously improves and regulates the sustained antibacterial property and slow-release performance of the salicylic acid component. While the composite improvement structure exerts the anti-inflammatory effect of salicylic acid itself, it also assists the anti-dandruff fungal effect of other components. At the same time, it alleviates the excessive adhesiveness and the feeling of unclean washing of the composition brought about when using gum arabic to modify salicylic acid alone. Under the condition of improved use experience, relatively excellent comprehensive anti-dandruff, anti-inflammatory, and long-lasting antibacterial effects are achieved.

[0018] Hereinafter, in conjunction with specific embodiments, the technical solutions and advantages of the present invention will be explained and described in more detail. It should be understood that the content presented in the specification and specific embodiments is only for more clearly explaining the technical solutions and advantages of the present invention, and does not limit the protection scope of the present invention. Those skilled in the art can, based on the disclosure content of the specification, obtain modified technical solutions for various reasonable transformations. As long as they do not deviate from the spirit of the present invention, all modified technical solutions should be understood to be included within the protection scope of the present invention. Specific Embodiments

[0019] The present invention is described in more detail below to facilitate the understanding of the invention.

[0020] Before the description of the specific embodiments, it should be noted that those skilled in the art can select appropriate raw materials according to the disclosure and teachings of the present disclosure, and use relevant testing equipment for relevant tests and obtain corresponding results. For raw materials without specifying the specific manufacturer or source, those skilled in the art can select raw materials that meet the corresponding requirements as the starting substances of the formula or method according to the disclosure content and requirements of this specification. The complex chemical substances of the present invention can be purchased from specific suppliers, or can come from suppliers of other identical or similar products; they can also be synthesized by the prior art known to those skilled in the art, and these synthesis techniques need not be discussed in detail here.

[0021] Table 1 lists the main raw materials used in the present invention and the corresponding acquisition channels or raw material origins. It should be noted that the raw materials not described in the present invention are raw material varieties that those skilled in the art can obtain based on common technical knowledge and existing market products.

[0022] Table 1: Main Products Used in the Present Invention

[0023]

[0024]

[0025] Example 1 (E-1)

[0026] Preparation of modified salicylic acid (microparticles): The following raw materials are weighed according to mass ratio: 55% salicylic acid; 15% surfactant; in this embodiment, the surfactant is polyquaternium-61; 5% 3-methyl-1,3-butanediol; and 10% bentonite. The balance of the above composition is balanced to 100% by anhydrous ethanol. In a typical embodiment, the weight proportion of anhydrous ethanol in the total composition is 10%-20%.

[0027] Salicylic acid and anhydrous ethanol are thoroughly stirred and mixed, and then a surfactant component and 3-methyl-1,3-butanediol are added in sequence and thoroughly stirred and mixed; the mixture is placed in a hot water bath heating container, the heating temperature is controlled at 65°C, the stirring device is controlled at -600 rpm, and the mixture is thoroughly stirred for 30 minutes to obtain a white uniform mixture; the white uniform mixture is spray-dried in a spray dryer (the spray drying process controls the feed temperature to 60°C, the hot air inlet temperature to 100°C, and the feed flow rate to 2 to 2.5 liters / hour), and the solvent portion (mainly ethanol) is removed to obtain a dry salicylic acid-containing mixture powder.

[0028] The above-mentioned bentonite content (accounting for 10% of the total composition by mass) is mixed with the salicylic acid mixture powder, and then put into a solid ball mill for dry grinding. The speed is controlled at 800 rpm, the ball milling time is 3 hours, and the ball-to-material ratio is 5:1 to obtain salicylic acid bentonite modified powder.

[0029] Next, the salicylic acid bentonite modified powder is placed in a heatable stirring container, and arabic gum is added at a ratio of 20-30 grams per 100 grams of salicylic acid bentonite modified powder. Purified water is added at a gum arabic: purified water mass ratio of 1:1.5, and stirred at a low speed of 150-250 rpm to allow the arabic gum to fully wrap the salicylic acid bentonite modified powder again. The stirring is continued for 15-30 minutes, and then the solution mixture is spray dried again (the spray drying process controls the feed temperature to 50°C, the hot air inlet temperature to 90-95°C, the feed flow rate to 2 to 2.5 liters / hour, and the discharge temperature to 60-80°C) to obtain the final modified salicylic acid component (E).

[0030] Preparation of dandruff reducing active composition (the following components are all in mass percentage):

[0031] Dichlorobenzyl alcohol: 0.5%;

[0032] Modified salicylic acid component: 15%

[0033] Oleuropein (Olive Leaf Extract): 1.5%

[0034] Rhamnolipid (glycolipid solubilizer): 5%

[0035] Isopentyldiol: 78%;

[0036] In the above embodiments, isopentyl glycol can also be replaced by purified water or glycerol. Considering the compatibility of each component, polyhydric alcohol is preferably used as the solvent (1,2 - hexanediol or butanediol can also be used). The above - mentioned components constitute 100% (by mass) of the composition of the anti - dandruff active composition. The above - mentioned components can be stirred in a container (for example, stirred at a low speed of 200 rpm for 1 - 2 minutes) until fully and uniformly mixed, and then left standing to obtain the anti - dandruff active composition for subsequent testing or use.

[0037] Generally speaking, according to the embodiments of the present invention, the salicylic acid molecules are modified by secondary combination. The layered inorganic bentonite molecules are used to insert into the salicylic acid molecules, so that some salicylic acid molecules can be assembled into the interlayer region of the bentonite molecules, while maintaining effective release during slow release; at the same time, the salicylic acid molecules modified for the first time are further wrapped by gum, which further stabilizes the stability of the layered structure of the inorganic bentonite molecules, and at the same time maintains the continuous release of salicylic acid molecules at a slower rate. At the same time, during the secondary modification process, the layered structure molecules of the inorganic bentonite have the opportunity to insert into the macromolecules of gum arabic, adjusting and appropriately reducing the viscosity of the gum arabic wrapping, effectively controlling the rheology and slow - release rate. It not only effectively reflects the effect of salicylic acid in dissolving the blocked grease, removing the grease in the hair follicles, effectively exfoliating the aged cutin layer, thereby relieving pore blockage and removing dandruff, but also the modified salicylic acid molecules stabilize the antifungal effects of plant leaf extracts and dichlorobenzyl alcohol. This will be elaborated in more detail in the following test examples.

[0038] Examples 2 - 5 (E - 2 to E - 5)

[0039] In the following examples, the modified salicylic acid components used in Example 1 are still adopted. The difference is that the usage ratios of each component are changed, and some other components are modified and replaced. The ratios in the following table (Table 1) are all in mass%.

[0040] Table 1: Component ratios of the anti - dandruff compositions in the examples

[0041]

[0042] Comparative Examples 1 - 4 (C - 1 to C - 4)

[0043] In this series of experimental examples, components substantially the same as those in Example 1 are adopted, with the difference being that different modified salicylic acid components are used. In the following experimental examples, each component still adopts the mass percentage ratio.

[0044] In one set of experimental examples, commercially purchased salicylic acid was modified to obtain modified salicylic acid C1. Different from the modification steps in Example 1, the modification of salicylic acid was only through the modification of bentonite, without the secondary modification of gum arabic. Specifically, in the preparation steps of modified salicylic acid C1:

[0045] Raw materials of the following components were weighed according to mass ratio, where salicylic acid was 55%; polyquaternium-61 accounted for 15%, 3-methyl-1,3-butanediol was 5%, and bentonite was 10%; the balance of the above composition was made up to 100% of the total composition mass with absolute ethanol.

[0046] Salicylic acid and absolute ethanol were fully stirred and mixed, and then the surfactant component and 3-methyl-1,3-butanediol were successively added and fully stirred and mixed; the above mixed solution was placed in a hot water bath heating container, the heating temperature was controlled at 65°C, and the stirring device was controlled at 600 revolutions / min and stirred for 30 minutes to obtain a white homogeneous mixture; the white homogeneous mixture was spray-dried into powder in a spray dryer (spray drying process controlled the feed temperature at 60°C, the hot air inlet temperature at 100°C, and the feed flow rate at 2 to 2.5 liters per hour), the solvent part was removed to obtain a dry powder of the salicylic acid mixture; next, the weighed bentonite was mixed with the powder of the salicylic acid mixture and dry-ground in a solid ball mill, the rotation speed was controlled at 800 rpm, the ball milling time was 3 hours, and the ball-to-material ratio was 5:1 to obtain a modified product, labeled as modified salicylic acid C1.

[0047] In another set of experimental examples, basically the same components as in Example 1 were used, except that commercially purchased salicylic acid was modified to obtain modified salicylic acid C2. Different from the modification steps in Example 1, the modification of salicylic acid was only through the modification of gum arabic, without the modification of bentonite. More specifically:

[0048] Commercially purchased salicylic acid was used. For every 100 grams of salicylic acid, 20 grams of cyclodextrin was added, and then it was added to 800 - 1000 grams of pure water and ultrasonically dispersed, and then heated at 50 - 60°C. This step increased the water solubility of salicylic acid, enabling more parts of salicylic acid to dissolve in the water phase. Next, in the above system, gum arabic was added at a ratio of 20 - 30 grams per 100 grams of salicylic acid raw material, and stirred at a speed of 200 - 300 rpm to make the gum arabic fully wrap the salicylic acid powder, and the stirring continued for 15 - 30 minutes. Thereafter, the solution mixture was spray-dried again (spray drying process controlled the feed temperature at 60°C, the hot air inlet temperature at 90 - 95°C, the feed flow rate at 2 to 2.5 liters per hour, and the discharge temperature was controlled at 50 - 70°C) to obtain the modified salicylic acid powder C2.

[0049] In another set of experimental examples, commercially available salicylic acid C3 was used as the corresponding component of the composition.

[0050] For the various components used in the above experimental examples, please refer to the description in Table 2 below.

[0051] Table 2: Component ratios of each comparative example

[0052]

[0053] Test Example 1:

[0054] According to the scientific research of existing washing and care products, it is known that a series of fermenting bacteria of Malassezia, such as Malassezia furfur, are the main inducements of dandruff. It is generally believed that the series of Malassezia strains are one of the important reasons for inducing and causing the proliferation of dandruff.

[0055] Therefore, in the first series of test experiments of the present invention, the composition samples of each example were used to test the antibacterial effect against Malassezia furfur, which causes symptoms such as dandruff and itching.

[0056] The commercially purchased standard strain Malassezia furfur (ATCC44344) was inoculated and cultured for enrichment. Malassezia furfur was cultured for 48 hours under conventional culture conditions (the culture medium was set as follows: malt extract agar: 60 g; ox bile: 20.0 g; Tween 40: 10.0 g; glyceryl monooleate: 2.5 g; distilled water: 1 L; natural state pH value, temperature maintained at 30 °C); thereafter, an excessive amount of sodium chloride solution was added to elute the culture, and the bacterial suspension was aspirated into a sterile test tube, and a 0.9% sterile sodium chloride solution was added to make a bacterial suspension of about 10 6 cfu / mL.

[0057] The determination of the antibacterial rate was carried out by the suspension quantitative method according to the evaluation method for the antibacterial and bacteriostatic effects of daily chemical products QB / T 2738-2012.

[0058] In the experimental cabinet, under the condition of uniform mixing, 10 mL of the compositions prepared in each example and comparative example were respectively placed in sterile test tubes, kept at a constant temperature of 25 °C for 5 min, 0.2 mL of the Malassezia furfur suspension was added, and after mixing, the timing started for 30 minutes, 1 hour (partial experimental values). After 1 hour of storage, the standing liquid was centrifuged, and the supernatant after centrifugation was replaced with the same amount of clear water, and then observed until 1 day and 3 days; thereafter, 0.5 mL of the mixed liquid was respectively taken, added to 4.5 mL of sterile PBS, left for 15 min, appropriately diluted and then poured onto a plate, and the viable bacterial colonies were counted after culturing with the corresponding culture medium at 35 °C for 48 h; and PBS was used instead of the active composition for reducing dandruff as the blank control for each experiment. The test was repeated 3 times and the average value was taken.

[0059] The antibacterial rate X = (R - S) / R × 100%

[0060] Where: X—the antibacterial rate %

[0061] R—the average recovered colonies of the control sample;

[0062] S—the average recovered colonies of the test sample

[0063] From this, the antibacterial rate X% is calculated, and the results are shown in Table 3 below.

[0064] Table 3: Antibacterial efficiency test of each experimental example of the anti-dandruff active composition

[0065]

[0066]

[0067] In the experiments of Test Example 1 series, the antibacterial effects and sustainability of different compositions on Malassezia furfur that causes dandruff were simulated under a simplified scenario. At the 1-hour time point in the test, the supernatant was centrifuged and replaced, which simulated the scenario where most of the shampoo composition was washed away after being applied to the surface where the flora might exist for a period of time. In the test experiment series, when the modified salicylic acid component (E) prepared by the process described in the inventive example increased (from 15% to 30% wt), at this time, the maximum antibacterial ratio increased and improved. This proves that while the anti-inflammatory auxiliary effect of the modified salicylic acid component plays a role, the dichlorobenzyl alcohol and olive leaf extract components that assist in antibacterial disinfection also play a comprehensive antibacterial effect. When the proportion of the modified salicylic acid component (E) exceeds 35%, the increase in the maximum antibacterial effect is no longer obvious, and at the same time, it may lead to negative impacts such as increased composition cost, poor fluidity, and deterioration of the user experience (see Test Example 2 below). Therefore, in this example, the proportion of the modified salicylic acid component (E) can reach 40%, but preferably, the proportion of the modified salicylic acid component (E) is between 15% wt and 35 wt%.

[0068] In addition, referring to the test results of the comparative tests, it can be seen that when only bentonite modification or gum arabic modification is used, the antibacterial effect is partially deteriorated, and almost all effective antibacterial components cannot maintain the antibacterial effect after simple washing without sufficient modification. In addition, the inventors surprisingly found that even when directly using untreated commercial salicylic acid as shown in Comparative Example 3, or adopting the modification means of a certain process, the effect is slightly lower than the bacteriostatic rate in the embodiments. This shows that the double modification of the salicylic acid component not only plays a role in the sufficient slow release and bacteriostasis of the salicylic acid component, but also plays an auxiliary role in the bactericidal effects of dichlorobenzyl alcohol and oleuropein. The inventors speculate that this is related to the accommodating effect of the layered structure of bentonite on the effective molecules and the coating effect of gum arabic.

[0069] The inventors also found that when only the salicylic acid component treated with gum arabic was used in the experiment of Comparative Example 2, within the test time of 30 minutes, the bacteriostatic rate was lower than the average bacteriostatic level of the 15% salicylic acid component. The inventors speculate that this may be related to the encapsulation and slow release properties of gum arabic. Due to the encapsulation of the gum, salicylic acid cannot reach the most effective amount of release in a short time. In this regard, the inventors also detected the bacteriostatic rate at the 1-hour time point for Example 1 and Comparative Example 2, and found that the bacteriostatic rate of Comparative Example 2 at the 1-hour time point was significantly higher than its bacteriostatic rate at 30 minutes, while the bacteriostatic rate of Example 1 at the 1-hour time point was only slightly higher than the bacteriostatic rate at 30 minutes. This shows that the slow release process of Comparative Example 2 is very slow and cannot reach the most effective release in the first 30 minutes, while Example 1 basically effectively releases the bacteriostatic effect of the modified salicylic acid in the 30-minute process, and relatively more effectively maintains the long-term bacteriostatic effect within 1 - 3 days. Although the inventors do not wish to be restricted by any theory in this regard, the inventors believe that the layered structure of bentonite will be inserted into the encapsulation structure of part of the gum arabic. This composite structure, compared with the simple encapsulation of gum arabic, has the effect of enhancing the molecular slow release speed, because the layered insertion structure can better export the effective molecules from the encapsulation structure.

[0070] Test Example 2

[0071] In the process of product R & D and market research, the inventors found that the single bacteriostatic rate is not the only criterion for measuring the applicability of the product. Therefore, subjective evaluations of each composition were also carried out for the users. During the test, 30 female subjects of various age groups were recruited, and all the testers self-identified that they had dandruff problems. During the test, the subjects were required to first wash their hair with 30°C clear water, then apply 10 ml of the composition of each example component, rub it with the scalp for 90 seconds, wash it with 35°C clear water, and then dry it with a hair dryer. Part of the test was carried out immediately after washing, and the continuous effect test was carried out after 2 days. After testing each composition, wait for 4 days and then carry out the next test cycle for another composition.

[0072] During the test, the subjects were required to conduct a scale test on "scalp feeling after application", "immediate improvement of dandruff", "fluffiness after washing", and "continuous improvement of dandruff (3 days after washing)". The subjective evaluation value was from 1 to 5 points, with 1 point being the worst (or least comfortable) and 5 points being the best (or most comfortable). Among the 30 subjects, finally 27 completed the test of all the compositions. Please complete the evaluation of each composition by the users who completed the test and take the average value. The test results are shown in the following table (rounded to 1 decimal place after taking the arithmetic mean):

[0073] Table 4: Test results of each dandruff-removing composition by the subjects

[0074]

[0075] From the above test results of the subjects, the corresponding technical solutions of the examples achieved relatively ideal comprehensive evaluation results. The inventor noticed that when directly using the salicylic acid component as the hair cleaning component, although better immediate improvement of dandruff could be achieved (Comparative Example 3 and Comparative Example 4), the immediate feeling of the users deteriorated significantly. The subjects generally reported that itching or stinging sensations occurred during the scalp rubbing and cleaning in Comparative Example 3 and Comparative Example 4. Moreover, the fluffiness of the hair after use also affected the evaluation of the subjects on the immediate dandruff-removing effect to a certain extent. When the fluffiness evaluation decreased significantly, the subjective evaluation of the immediate dandruff treatment effect was also moderately lowered. In addition, for the technical solution using only gum arabic (Comparative Example 2) and the implementation example using glycerol as the solvent, the application feeling of the subjects deteriorated, and there was a feeling of incomplete rinsing, which might be related to the adhesiveness of gum arabic. When adding the layered bentonite to insert or break the macromolecular association of gum arabic, the application feeling improved. When only using the bentonite-modified salicylic acid component, the slow release effect of salicylic acid was insufficient, resulting in certain scalp irritation and also unable to maintain a good long-term dandruff removal effect. In addition, although the subjects in Examples 2-4 reported better dandruff removal effects, the fluffiness and application feeling decreased. Therefore, when the composition of the implementation example of the present invention is applied to daily cleaning products rather than disinfection or medical compositions, preferably the modified salicylic acid component does not exceed 35 wt%, more preferably does not exceed 30 wt%. Finally, when only using the gum arabic or bentonite-modified salicylic acid component to clean the scalp, the best fluffiness after washing and scalp application feeling were not obtained. This might be because the appropriate swelling layered structure of bentonite slowed down the adhesion feeling of gum arabic, and at the same time maintained a certain hair smoothness after immediate cleaning, obtaining a better feeling after cleaning.

[0076] For the technical solution of the present invention, the inventor used bentonite and gum arabic to compound and modify the salicylic acid component, while improving and regulating the sustained antibacterial property and slow-release performance of the salicylic acid component, so that while the composite improved structure exerted the anti-inflammatory effect of salicylic acid itself, it also assisted the anti-dandruff fungal effect of olive leaf extract and dichlorobenzyl alcohol. At the same time, it alleviated the excessive adhesiveness and the feeling of unclean washing of the composition brought about by the modification of salicylic acid with gum arabic alone. Under the conditions improved by the two, relatively excellent comprehensive dandruff removal, anti-inflammatory, sustained antibacterial and use experience were achieved.

[0077] For the technical solution of the present invention, the inventor does not wish to be restricted by any chemical or physical theoretical explanations. However, according to the components of the composition of the present invention, bentonite belongs to an inorganic ion clay, which can be used as an additive in cosmetics. Its basic structural unit is a layered structure composed of layered silicon oxygen tetrahedrons sandwiching aluminum oxygen polyhedrons. The main layer board can carry negative charges, and the ions balancing the negative charges are cations such as Li, Na, Ca, etc. (depending on the types of cations carried by different types of bentonite). Since these ions are usually combined with the tetrahedron in an unstable state, the interlayer binding force is weak. Therefore, through physical reactions, interlayer cation exchange can be achieved, and salicylic acid molecules or other effective components have the opportunity to exchange and assemble into the interlayer region to form a composite material. In addition, the secondary encapsulation of gum arabic can give a certain protective effect to the salicylic acid molecules mixed with the bentonite component, making it have slow-release performance. Here, although gum arabic has a low viscosity at a low concentration, the encapsulation of gum arabic alone will cause users to experience adverse feelings such as adhesiveness or unclean washing. When the layered structure of bentonite inserts or truncates gum arabic, its adhesiveness decreases, that is, it provides a certain slow-release export effect and alleviates the adverse experience brought about by the use of gum arabic alone.

[0078] Finally, it should be noted that according to the technical solution of the present invention, in addition to the components in the examples and the claimed technical solutions, other components may also be included (that is, the composition of the present invention can be used as a formula stock solution for the preparation of other related products). The technical solution of the present invention may also be composed only of the components in the said examples and the claimed technical solutions, and no other elements or components need to be included or contained.

[0079] According to the embodiments and technical content described in the specification of the present invention, the present invention can at least provide the following technical solutions: Although the present disclosure includes specific embodiments, it is obvious to those skilled in the art that various substitutions or changes in form and detail can be made to these embodiments without departing from the gist and scope of the invention of the claims and their equivalent technical solutions. The embodiments described herein should be considered in an illustrative sense only and not for the purpose of limitation. The description of the features and aspects in each embodiment is considered applicable to the similar features and aspects in other embodiments. Therefore, the scope of the present application should not be limited by the specific description, but by the technical solutions of the claims, and all changes within the scope of the claims and their equivalents are construed as being included in the technical solutions of the present application.

Claims

1. An active composition for reducing dandruff, characterized in that, Calculated by mass percentage, the active composition comprises the following components: Dichlorobenzyl alcohol, 0.5% to 1%; Modified salicylic acid component, 10% to 35%; Olive leaf extract, 1% to 10%; Glycolipid solubilizer, 5% to 10%, and the glycolipid solubilizer is rhamnolipid and / or sophorolipid; Isopentyl glycol, 1,2 - hexanediol or butanediol, 50% to 80%; and Wherein the modified salicylic acid component is prepared by first modifying salicylic acid with bentonite and then modifying it with arabic gum; the modified salicylic acid component is obtained through the following process: Prepare raw materials salicylic acid, surface active component, 3 - methyl - 1,3 - butanediol, bentonite, anhydrous ethanol, wherein salicylic acid accounts for 55% to 60% of the total mass of the above raw materials, and bentonite accounts for 5 to 10% of the total mass of the above raw materials; Fully stir and mix salicylic acid with anhydrous ethanol, then sequentially add the surface active component and 3 - methyl - 1,3 - butanediol and fully stir and mix; heat the above - mentioned mixture and continuously stir to obtain a white homogeneous mixture; spray - dry the white homogeneous mixture in a spray dryer to obtain a dry salicylic acid - containing mixture powder; Mix bentonite with the salicylic acid - containing mixture powder, and enter a solid ball mill for dry grinding to obtain a salicylic acid - bentonite modified powder; And Put the salicylic acid - bentonite modified powder into a container, add arabic gum according to the ratio of 20 grams to 30 grams of arabic gum per 100 grams of salicylic acid - bentonite modified powder, add pure water according to the mass ratio of arabic gum: pure water of 1:(1 - 1.5), and then stir so that the arabic gum fully wraps the salicylic acid - bentonite modified powder again; After that, spray - dry the solution mixture again to obtain the final modified salicylic acid component.

2. The anti-dandruff active composition according to claim 1, characterized in that, The modified salicylic acid component is obtained through the following specific process: Weigh the raw materials of the following components according to the mass ratio, wherein salicylic acid is 55% - 60%; polyquaternium - 61 as the surface active component is 10% - 15%, 3 - methyl - 1,3 - butanediol is 5% - 10%, and bentonite is 5 - 10%; the balance of the above composition is made up to 100 mass% with anhydrous ethanol; Fully stir and mix salicylic acid with anhydrous ethanol, then sequentially add polyquaternium - 61 and 3 - methyl - 1,3 - butanediol and fully stir and mix; put the above - mentioned mixture into a hot - water - bath heating container, control the heating temperature at 65 - 70 °C, and control the stirring device at 500 - 600 revolutions per minute and stir fully for 30 - 45 minutes to obtain a white homogeneous mixture; spray - dry the white homogeneous mixture into powder in a spray dryer, wherein the spray - drying process controls the feed temperature at 60 °C, the hot - air inlet temperature at 100 °C, and the feed flow rate at 2 liters per hour to 2.5 liters per hour, and remove the solvent ethanol to obtain a dry salicylic acid - containing mixture powder; Then, mix bentonite with the salicylic acid - containing mixture powder, enter a solid ball mill for dry grinding, control the rotation speed at 600 - 800 rpm, the ball - milling time at 2 to 3 hours, and the ball - to - material ratio at (3 - 5):1 to obtain a salicylic acid - bentonite modified powder; Next, put the modified salicylic acid bentonite powder into a heatable stirring container, add gum arabic in a ratio of 20 - 30 grams per 100 grams of the modified salicylic acid bentonite powder, add pure water according to the mass ratio of gum arabic : pure water of 1:(1 - 1.5), and stir at a speed of 150 - 250 rpm so that the gum arabic fully coats the modified salicylic acid bentonite powder again. Stir for 15 - 30 minutes. After that, spray-dry the solution mixture again. The spray-drying process controls the feed temperature at 50°C, the hot air inlet temperature at 90 - 95°C, the feed flow rate at 2 to 2.5 liters per hour, and the outlet temperature is controlled at 60 - 80°C to obtain the final modified salicylic acid component.

3. A method for preparing an active composition for reducing dandruff, characterized in that, The method includes the following steps: The first step, preparation of the modified salicylic acid component: Prepare raw materials salicylic acid, surface active component, 3-methyl-1,3-butanediol, bentonite, and absolute ethanol, where salicylic acid accounts for 55% to 60% of the total mass of the above raw materials, and bentonite accounts for 5% to 10% of the total mass of the above raw materials; Fully stir and mix salicylic acid and absolute ethanol, then sequentially add the surface active component and 3-methyl-1,3-butanediol and stir and mix well; heat the obtained mixture and keep stirring to obtain a white homogeneous mixture; spray-dry the white homogeneous mixture in a spray dryer to obtain a dried salicylic acid mixture powder; Mix the bentonite with the salicylic acid mixture powder and enter a solid ball mill for dry grinding to obtain the modified salicylic acid bentonite powder; and Put the modified salicylic acid bentonite powder into a container, add gum arabic in a ratio of 20 - 30 grams per 100 grams of the modified salicylic acid bentonite powder, add pure water according to the mass ratio of gum arabic : pure water of 1:(1 - 1.5), and then stir so that the gum arabic fully coats the modified salicylic acid bentonite powder again; After that, spray-dry the solution mixture again to obtain the final modified salicylic acid component; The second step, prepare the anti-dandruff active composition using the final modified salicylic acid component. Calculated by mass percentage, the active composition includes the following components: Dichlorobenzyl alcohol, 0.5% to 1%; The final modified salicylic acid component, 10% to 35%; Olive leaf extract, 1% to 10%; Glycolipid solubilizer, 5% to 10%, and the glycolipid solubilizer is rhamnolipid and / or sophorolipid; Isopentyl glycol, 1,2-hexanediol or butanediol, 50% to 80%; Mix and stir the above components in a container to obtain the anti-dandruff active composition.

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