Cosmetic composition for acne treatment and method for preparing the same

Abstract

The present application provides a kind of cosmetic composition for acne and its preparation method, it is related to the technical field of cosmetics.The cosmetic composition comprises by mass percentage 0.01-2.0% of acacia gum, 0.01-2.0% of sphingomonad ferment product extract, 0.01-10% of exfoliating agent, 0.01-1.0% of oil control agent, 0.001-0.005% of bacteriostatic agent, 0.01-2.0% of anti-inflammatory agent and 0.01-2.0% of soothing and repairing agent; the balance is cosmetic base; wherein the exfoliating agent includes one or more of coated multi-fruit acid, coated azelaic acid and coated salicylic acid; the anti-inflammatory agent includes 100 and 1609; and the soothing and repairing agent includes 100, which solves the technical problems of difficult thickening, insufficient mildness and insufficient refreshing after absorption of acne-removing products.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a cosmetic composition and preparation method for treating acne. Background Technology

[0002] Acne vulgaris, also known as comedones, is a skin condition caused by chronic inflammation of the sebaceous glands. Comedones develop from non-inflammatory follicular reactions due to tightly packed hair follicles and excessive angles. The incidence of acne is concentrated in people aged 11-25, primarily affecting the face, chest, and back, and sometimes the limbs. Severe acne can develop into pustules and cysts, significantly impacting appearance and mental well-being. Some people squeeze pustules, which can leave scars, known as acne pits, after rupture. Acne sufferers are prone to depression and low self-esteem, causing significant harm to their physical and mental health.

[0003] Acne grading is an important basis for acne treatment and efficacy evaluation. Dermatologically, acne is generally divided into 3 degrees and 4 grades: Mild (Grade I): only comedones; Moderate (Grade II): inflammatory papules; Moderate (Grade III): pustules; Severe (Grade IV): cysts and nodules.

[0004] The causes of acne include: 1. Abnormal regulation of sebaceous glands by androgens, leading to hyperfunction of sebaceous glands; 2. Abnormal keratinization of the sebaceous gland ducts, i.e., excessive keratinization of hair follicles; 3. Overgrowth of Propionibacterium acnes; 4. Inflammatory immune response. Other factors that may cause acne include: diet, skin cleansing, living and working environment, light exposure, and the effects of cosmetics.

[0005] In existing methods for preparing acne-removing cosmetics, salicylic acid or its derivatives are commonly used as exfoliating agents. For example, CN113893209A discloses an acne-removing and repairing functional composition comprising salicylic acid, Centella asiatica extract, Salix babylonica extract, 4-terpineol, Chlorella vulgaris extract, ergothioneine, Pine mushroom extract, Amaranthus urinaria leaf extract, and 10-hydroxydecanoic acid. Salicylic acid is a lipid-soluble compound and has a certain degree of skin irritation. Encapsulating salicylic acid in microcapsules or preparing salicylic acid derivatives can improve its water solubility and enhance its sustained-release properties, thereby reducing its irritation. For example, CN111228153A discloses a composition with a synergistic acne-removing effect, comprising zinc PCA, encapsulated salicylic acid, quaternary ammonium salt-73, niacinamide, and tea tree oil.

[0006] Salicylic acid has poor water solubility. Adding alkaline substances, such as potassium hydroxide, to neutralize it and form a salt improves its solubility, but reduces its acne-fighting effect. Therefore, many salicylic acid products still have a relatively low pH, resulting in higher irritation and limiting their application to spot treatment. Salicylate salts, encapsulated salicylic acid, and cosmetics using zinc PCA as an oil-controlling agent are all difficult to thicken because commonly used thickeners in cosmetics are not ion-resistant. In summary, the main drawbacks of commercially available acne-fighting products are: insufficient gentleness, excessive stickiness, and a lack of refreshing feeling after absorption. Therefore, improving these shortcomings of acne-fighting products is a pressing issue that needs to be addressed.

[0007] In view of this, the present invention is hereby proposed. Summary of the Invention

[0008] The purpose of this invention is to provide a cosmetic composition for acne treatment and a method for preparing the same, so as to alleviate at least one of the many defects of commercially available acne treatments in the prior art. The cosmetic composition for acne treatment of this invention at least alleviates the technical problems of acne treatment products being intolerant to ions, difficult to thicken, not gentle enough, and not refreshing enough after absorption.

[0009] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0010] According to one aspect of the present invention, a cosmetic composition for acne treatment is provided, comprising, by weight percentage: 0.01-2.0% of *Sphingomyelinum praecox* gum, 0.01-2.0% of *Sphingomonas* fermentation product extract, 0.01-10% of an exfoliating agent, 0.01-1.0% of an oil-controlling agent, 0.001-0.005% of an antibacterial agent, 0.01-2.0% of an anti-inflammatory agent, and 0.01-2.0% of a soothing and repairing agent; the balance being a cosmetic base.

[0011] The exfoliating agent comprises one or more of the following: encapsulated multiple fruit acids, encapsulated azelaic acid, and encapsulated salicylic acid; the encapsulated azelaic acid includes PG6 ACTIVE AA-GLY C; and the encapsulated multiple fruit acids include SKINPERF LWG.

[0012] The anti-inflammatory agents include SYMRELIEF® 100 and SYMSITIVE® 1609;

[0013] The soothing and repairing agents include SYMREPAIR® 100.

[0014] Preferably, the stripping agent comprises PG6 ACTIVE AA-GLY C and SKINPERF LWG;

[0015] Preferably, the oil-controlling agent includes one or more of zinc PCA, plankton extract, and spider lily extract, with zinc PCA being the most preferred.

[0016] Preferably, the antibacterial agent comprises one or more of quaternary ammonium salt-73, capryloyl glycine, and white willow bark extract, preferably quaternary ammonium salt-73;

[0017] Preferably, the anti-inflammatory agent further includes one or more of panthenol, dipotassium glycyrrhizate, and licorice derivatives;

[0018] Preferably, the soothing and repairing agent further includes one or more of asiaticoside, centella asiatica extract, and ceramide;

[0019] Preferably, the pH of the cosmetic composition for acne treatment is 4.5 to 6.0, more preferably 4.5 to 5.5.

[0020] Preferably, the cosmetic composition comprises *Sphingomonas sphingolipidae* gum, *Sphingomonas* fermentation product extract, PG6ACTIVE AA-GLY C, SKINPERF LWG, PCA zinc, quaternary ammonium salt-73, SYMRELIEF® 100, SYMSITIVE® 1609, and SYMREPAIR® 100;

[0021] Preferably, the cosmetic composition comprises 0.3-0.5% of *Sphingomonas sphingosine monophosphate* fermentation product extract, 0.15-0.25% of PG6 ACTIVE AA-GLY C, 2% of SKINPERF LWG, 0.25% of PCA zinc, 0.002-0.003% of quaternary ammonium salt-73, 0.2% of SYMRELIEF® 100, 1.0-2.0% of SYMSITIVE® 1609, and 1% of SYMREPAIR® 100; the balance being a cosmetic base.

[0022] Preferably, the cosmetic matrix includes one or more of the following: solvent, surfactant, solubilizer, thickener, skin conditioner, oil, moisturizer, preservative, chelating agent, pH adjuster, and fragrance.

[0023] Preferably, the cosmetic composition is an aqueous solution, emulsion, cream, or gel.

[0024] Preferably, the cosmetic composition is a toner, lotion, essence, emulsion, cream, serum, essence lotion, gel, spray, mask, serum, cream mask, or sheet mask.

[0025] Preferably, by weight percentage, it comprises 0.3-0.5% of *Sphingomonas sphingosine mononitrate* gum, 0.15-0.25% of *Sphingomonas sphingosine mononitrate* fermentation product extract, 2% of PG6 ACTIVE AA-GLY C, 2% of SKINPERF LWG, 0.25% of PCA zinc, 0.003% of quaternary ammonium salt-73, 0.2% of SYMRELIEF® 100, 1.0% of SYMSITIVE® 1609, and 1% of SYMREPAIR® 100;

[0026] It also contains a cosmetic matrix comprising 3% glycerin, 0.02% disodium EDTA, 0.5% 1,2-hexanediol, 0.5% p-hydroxyacetophenone, and 3% 1,3-propanediol; it also includes a pH adjuster and a solubilizer, with the remainder being deionized water.

[0027] Preferably, by weight percentage, it comprises 0.3-0.45% *Sphingomonas* fermentation product extract, 0.15-0.22% PG6 ACTIVE AA-GLY C, 2% SKINPERF LWG, 0.25% PCA zinc, 0.002% quaternary ammonium salt-73, 0.2% SYMRELIEF® 100, 1.2% SYMSITIVE® 1609, and 1% SYMREPAIR® 100;

[0028] It also contains a cosmetic base, which includes 3% glycerin, 0.2% sodium stearoyl glutamate, 0.05% disodium EDTA, 3-5% stearyl alcohol, 1% dimethyl silicone oil KF-96A-6T, 5% Cetiol® Ultimate, 1% Emulgade® 165 CN, 1% Montanov L, 0.5% 1,2-hexanediol, 0.5% p-hydroxyacetophenone, and 3% 1,3-propanediol.

[0029] It also includes pH adjusters and flavorings, with the remainder being deionized water.

[0030] According to another aspect of the present invention, the present invention also provides a method for preparing the above-mentioned cosmetic composition, comprising mixing the components according to the formulation amounts;

[0031] Preferably, the preparation method includes: dissolving the antibacterial agent and the oil-controlling agent separately; dispersing the extracts of *Sphingomyelinum praecox* and *Sphingomonas sphingosine* fermentation products in a solvent; then mixing the dissolved or dispersed systems; and finally adding the remaining components and mixing them evenly to obtain the cosmetic composition.

[0032] Preferably, the preparation method includes:

[0033] Quaternary ammonium salt-73 was dissolved in a polyol to obtain the first system; zinc PCA was dissolved in a portion of the prescribed amount of deionized water to obtain the second system; and the fermentation products of Astrophytum esculentum and Sphingomonas were dispersed in the remaining amount of deionized water to obtain the third system.

[0034] The first system, the second system, the third system, and the remaining ingredients are mixed evenly to obtain the cosmetic composition;

[0035] Preferably, quaternary ammonium salt-73 is dissolved in a polyol at 60-75°C to obtain the first system;

[0036] Preferably, quaternary ammonium salt-73 is dissolved in a polyol at 65-75°C to obtain the first system;

[0037] Preferably, zinc PCA is dissolved in a portion of the formulation amount of deionized water at 50-60°C to obtain the second system;

[0038] Preferably, the extracts of *Sphingomonas* fermentation product, which are uniformly dispersed in the remaining amount of deionized water, are heated to 82-88°C, homogenized for 5-10 minutes, cooled to 50-55°C, and then mixed with other ingredients.

[0039] Compared with the prior art, the present invention has the following beneficial effects:

[0040] The cosmetic composition for acne treatment provided by this invention comprises Aspergillus oryzae gum, Sphingomonas fermentation product extract, exfoliating agent, oil-controlling agent, antibacterial agent, anti-inflammatory agent, and soothing and repairing agent.

[0041] The exfoliating agent includes one or more of the following: encapsulated multiple fruit acids, encapsulated azelaic acid, and encapsulated salicylic acid. The encapsulation of acids gives the product exfoliating properties while maintaining its gentleness. Common exfoliating agents are only effective under acidic conditions, but the exfoliating agent in this application is effective in the pH range of 5-5.5, avoiding excessive acidity in the overall cosmetic composition. This makes it gentler than commercially available exfoliating acne treatment products, overcoming the shortcomings of existing acne treatment products that are not gentle enough.

[0042] Furthermore, commonly used exfoliating agents are highly ionic and acidic, making it difficult to thicken traditional cosmetic compositions containing exfoliating agents. However, this invention improves the thickening of cosmetic compositions from two aspects: exfoliating agents and thickeners. Using encapsulated acid as an exfoliating agent avoids making the system pH too low. At the same time, the use of Sphingomonas fermentation product extract and Astragalus membranaceus gum as thickening components has the advantages of acid and electrolyte resistance, enabling the cosmetic composition to have better viscosity under acidic conditions, resulting in a refreshing feel on the skin and a sense of rapid absorption during application.

[0043] Peeling cosmetic compositions can be irritating, so traditional peeling cosmetics are mostly applied to the affected area and cannot be used on the entire face. This invention reduces irritation by using an encapsulating peeling agent, and also incorporates soothing and repairing components into the composition, allowing the entire product to be applied to the face, further improving the gentleness of the cosmetic composition.

[0044] Meanwhile, the soothing and repairing agent includes SYMREPAIR® 100, which also has antihistamine and anti-inflammatory effects. Combined with anti-inflammatory agents containing SYMREPAIR® 100 and SYMSITIVE® 1609, the cosmetic composition of the present invention has soothing, repairing and acne-reducing effects, so that the composition does not need to be used topically and can be applied to the whole face without irritation.

[0045] This invention's cosmetic composition, through the combined use of specific thickening components and exfoliating agents, oil-controlling agents, antibacterial agents, anti-inflammatory agents, and soothing and repairing agents, synergistically targets acne treatment from four angles: anti-inflammatory, antibacterial, oil-controlling, and exfoliating, resulting in a rapid acne-removing effect. Unlike commercially available acne products that are mostly applied topically, this cosmetic composition can be applied to the entire face and is very gentle. By adding anti-inflammatory and repairing agents, the cosmetic composition is gentle and non-irritating while also providing soothing, repairing, and acne-removing effects. This composition can be used not only in acne-removing cosmetics but also in soothing, repairing, and moisturizing skincare products. Attached Figure Description

[0046] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0047] Figure 1 The image shows the red zone data acquisition images for Example 3, where A is the red zone data acquisition image for day 0, B is the red zone data acquisition image for day 14, and C is the red zone data acquisition image for day 28.

[0048] Figure 2 The images show stability test photos of the embodiments and comparative examples. The left image is a stability test photo of the embodiment, and the right image is a stability test photo of comparative example 7. Detailed Implementation

[0049] The technical solution of the present invention will be clearly and completely described below with reference to the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0050] It should be noted that:

[0051] In this invention, unless otherwise specified, all embodiments and preferred embodiments mentioned herein can be combined to form new technical solutions; all technical features and preferred features mentioned herein can be combined to form new technical solutions; and the components involved or their preferred components can be combined to form new technical solutions.

[0052] In this invention, unless otherwise specified, the numerical range "a~b" represents an abbreviation of any combination of real numbers between a and b, where a and b are both real numbers. For example, the numerical range "6~22" means that all real numbers between "6~22" have been listed in this document, and "6~22" is simply an abbreviation of these numerical combinations.

[0053] The "scope" disclosed in this invention can be in the form of a lower limit and an upper limit, and can be one or more lower limits and one or more upper limits, respectively.

[0054] In this invention, unless otherwise stated, the various reaction or operation steps may be performed sequentially or not in sequence.

[0055] Unless otherwise stated, the technical and scientific terms used herein have the same meanings as those familiar to those skilled in the art. Furthermore, any methods or materials similar to or equivalent to those described herein may also be used in this invention.

[0056] According to one aspect of the present invention, a cosmetic composition for treating acne is provided, comprising *Sphingomonas sphingosine* fermentation product extract, exfoliating agent, oil-controlling agent, antibacterial agent, anti-inflammatory agent, and soothing and repairing agent.

[0057] The exfoliating agent comprises one or more of the following: encapsulated multiple fruit acids, encapsulated azelaic acid, and encapsulated salicylic acid; the encapsulated azelaic acid includes PG6 ACTIVE AA-GLY C; and the encapsulated multiple fruit acids include SKINPERF LWG.

[0058] The anti-inflammatory agents include SYMRELIEF® 100 and SYMSITIVE® 1609; the soothing and repairing agents include SYMREPAIR® 100.

[0059] Caesalpinia spicosa gum (also referred to as Caesalpinia spicosa gum in this article) is made from Caesalpinia spicosa. Its main component is a neutral galactomannan, which can adjust the sensory quality of products and is safe for human use with no toxic side effects. Sphingomonas fermentation product extract (also referred to as Sphingomonas fermentation product extract in this article) is derived from Sphingomonas. The fermentation products contain a variety of highly effective ingredients that can condition the skin and delay skin aging.

[0060] While Sphingomonas fermentation product extract is resistant to acids and strong electrolytes, its use alone can lead to a "jelly-like" consistency (the colloid tends to slide in bulk and doesn't adhere to the container) during stability studies at low temperatures. Asparagus cochinchinensis gum, on the other hand, is a long-flowing thickener that doesn't readily thicken systems. Using it alone results in poor thickening performance, making it unsuitable for preparing high-viscosity serums or gels, and its concentration exceeding 0.5% can cause pilling. Combining Sphingomonas fermentation product extract and Asparagus cochinchinensis gum provides excellent complementarity, offering both acid and electrolyte resistance while effectively thickening the product and preventing a "jelly-like" texture in cosmetics. By combining Sphingomonas fermentation product extract and Asparagus cochinchinensis gum in a suitable ratio, their complementary properties enhance acid and electrolyte resistance, providing excellent thickening for cosmetic compositions such as toners and serums, resulting in a smoother absorption experience during application.

[0061] The cosmetic composition of this invention also contains exfoliating agents, oil-controlling agents, antibacterial agents, anti-inflammatory agents, and soothing and repairing agents, which work synergistically from four angles—anti-inflammatory, antibacterial, oil-controlling, and exfoliating—to achieve a rapid acne-removing effect.

[0062] Exfoliating agents, also known as keratolytic agents, can peel away the stratum corneum while stimulating the proliferation of epidermal and dermal fibrous tissues. This process involves initial damage followed by repair of the skin barrier. Exfoliating agents include one or more of the following: encapsulated multiple fruit acids, encapsulated azelaic acid, and encapsulated salicylic acid. Encapsulated azelaic acid includes PG6 ACTIVE AA-GLY C, which contains polyglycerol-6, azelaic acid, and glycine in a ratio of 55:40:5.

[0063] Fruit acids are various organic acids extracted from fruits. They are a collective term for a series of naturally occurring organic acids and are effective components found in many natural fruits or yogurt. The term "multiple fruit acids" refers to a complex composed of at least two fruit acids, including at least two of glycolic acid, lactic acid, citric acid, lactobionic acid, malic acid, gluconic acid, and tartaric acid, preferably including glycolic acid, lactic acid, and citric acid. The encapsulated multiple fruit acids include SKINPERF LWG, containing water, glycolic acid, lactic acid, sodium magnesium silicate, citric acid, and xanthan gum in the following proportions: 65.1; 14.7; 7.2; 6.3; 6.07; 0.63.

[0064] The salicylic acid can be encapsulated with either Best-Carrier® Salicylic Acid 30 or BioGenic SA-200.

[0065] In some alternative embodiments, the oil-controlling agent includes one or more of zinc PCA, plankton extract, and bird's eye root extract, preferably zinc PCA.

[0066] Zinc PCA is a product of the combination of zinc and the natural moisturizing factor "pyrrolidone carboxylic acid (PCA)". Zinc PCA can inhibit sebum secretion and bacterial growth. Plankton extract (Tetraselmis Suecica extract) can activate various physiological activities of the skin, promote metabolism, and enhance cell resistance. Lotus root extract can be selected from one or more of Lotus Corniculata flower extract, Lotus Corniculata seed extract, and Lotus Japonica root nodule extract, and has a soothing and moisturizing effect.

[0067] The antibacterial agent is primarily used to inhibit Propionibacterium acnes. In some preferred embodiments, the antibacterial agent includes one or more of Quaternium-73, octanoylglycine, and white willow bark extract, preferably Quaternium-73.

[0068] Quaternary ammonium salt-73 possesses extremely strong antibacterial activity, capable of disrupting bacterial and fungal cell membranes, exhibiting excellent effects against Propionibacterium acnes, and also inhibiting melanin formation. It is highly effective while maintaining good safety. Caprylyl glycine has antibacterial effects, strongly inhibiting Staphylococcus epidermidis and Propionibacterium acnes, and can also suppress excessive sebum secretion, exhibiting good skin affinity. The main active ingredient in white willow (SALIX ALBA) bark extract is salicin, which has anti-inflammatory properties.

[0069] Anti-inflammatory agents include SYMRELIEF® 100 and SYMSITIVE® 1609. SYMRELIEF® 100 (INCI name: Bisabolol (and) Zingiber Officinale (Ginger) Root Extract) is a synergistic blend of synthetic bisabolol and high-purity natural ginger extract. SYMSITIVE® 1609 (4-tert-butylcyclohexanol hydroxyl) (INCI name: Pentylene Glycol (and) 4-t-Butylcyclohexanol) acts as a "sensitivity regulator," reducing intracellular calcium loss and restoring skin sensitivity to normal levels. Anti-inflammatory agents may also optionally include one or more of panthenol, dipotassium glycyrrhizate, and licorice derivatives. Panthenol has anti-inflammatory, skin-conditioning, and potent moisturizing properties. Dipotassium glycyrrhizate has anti-inflammatory, soothing, anti-allergic, and immunomodulatory effects. Licorice derivatives, such as but not limited to licorice flavonoids, glycyrrhizic acid, glycyrrhizic acid ammonium, dipotassium glycyrrhizate, disodium glycyrrhizate, potassium glycyrrhizate, and trisodium glycyrrhizate, all have good anti-inflammatory effects.

[0070] The soothing and repairing agent includes SYMREPAIR® 100. SYMREPAIR® 100 is a skin barrier repair complex. The soothing and repairing agent may also optionally include one or more of asiaticoside, centella asiatica extract, and ceramides. Acetonide is a triterpenoid saponin found in centella asiatica, possessing antioxidant, antibacterial, and immunomodulatory functions. Centella asiatica extract promotes the vitality of scar fibroblasts and also has whitening, spot-removing, antibacterial, and anti-inflammatory effects. Ceramides are lipids found in the skin that play an important role in the formation of the stratum corneum. When the skin barrier function is impaired, supplementing the skin with ceramides can restore moisturizing and barrier function.

[0071] The cosmetic composition for acne treatment, by weight percentage, comprises: 0.01-2.0% of *Sphaerocephala indicum* gelatin, for example, but not limited to, 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.45%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, or 2.0%; 0.01-2.0% of *Sphingomonas sphingosine monophosphate* fermentation product extract, for example, but not limited to, 0.01%, 0.05%, 0.1%, 0.15%, 0.2%, 0.22%, 0.25%, 0.3%, 0.4%, 0.45%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8%, or 2.0%; 0.01-10% of an exfoliating agent, for example, but not limited to, 0.01%, 0.05%, 0.1%, 0.5%, 1.0%, 2.0%, 5.0%, 7.5%, or 10%; and 0.0% of an oil-controlling agent. 1~1.0%, for example, but not limited to 0.01%, 0.05%, 0.1%, 0.5%, 1.0%, 2.0%, 5.0%, 7.5%, 10%; antibacterial agent 0.001~0.005%, 0.001%, 0.002%, 0.003%, 0.004% or 0.005%; anti-inflammatory agent 0.01%-2.0%, for example, but not limited to 0.01%, 0.05%, 0.1%, 0. 2%, 0.3%, 0.4%, 0.45%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8% or 2.0%; and 0.01-2.0% of soothing and repairing agents, for example, but not limited to, 0.01%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.45%, 0.5%, 0.8%, 1%, 1.2%, 1.5%, 1.8% or 2.0%; the balance being cosmetic base.

[0072] In some preferred embodiments, the cosmetic composition comprises, by weight percentage, *Sphingomonas* fermentation product extract, PG6 ACTIVE AA-GLY C (encapsulated azelaic acid), SKINPERF LWG (encapsulated multiple fruit acids), zinc PCA, quaternary ammonium salt-73, SYMRELIEF® 100, SYMSITIVE® 1609, and SYMREPAIR® 100.

[0073] In some preferred embodiments, the cosmetic composition comprises 0.3-0.5% of *Sphingomonas sphingosine monophosphate* fermentation product extract, 0.15-0.25% of PG6 ACTIVE AA-GLY C, 2% of SKINPERF LWG, 0.25% of PCA zinc, 0.002-0.003% of Quaternium-73, 0.2% of SYMRELIEF® 100, 1.0-2.0% of SYMSITIVE® 1609, and 1% of SYMREPAIR® 100; the balance being a cosmetic base.

[0074] This cosmetic composition overcomes the shortcomings of existing acne treatment products, which are often not gentle enough. It utilizes encapsulated multiple fruit acids, providing both exfoliation and gentleness. It also incorporates PG6ACTIVE AA-GLY C (encapsulated azelaic acid), overcoming the poor water solubility of azelaic acid. Furthermore, the addition of glycine reduces the irritation of azelaic acid, making the cosmetic composition even gentler. This cosmetic composition does not require local application and can be applied to the entire face without irritation. Compared to commercially available cosmetics, this cosmetic composition provides rapid and effective treatment for acne, while also offering soothing and repairing effects. It leaves a refreshing and non-sticky feeling during and after use, demonstrating broad market application prospects.

[0075] It is understood that the cosmetic composition further comprises a cosmetic matrix acceptable to the art, and those skilled in the art can adapt the cosmetic matrix to the dosage form of the cosmetic according to methods well known in the art and described in various general and more specific textbooks, references, process manuals, product instructions, and standard documents. The cosmetic matrix includes, but is not limited to, one or more of solvents, surfactants, solubilizers, thickeners, skin conditioning agents, moisturizers, oils, preservatives, chelating agents, and fragrances, preferably including conditioning agents, moisturizers, oils, preservatives, and chelating agents.

[0076] In some preferred embodiments, the solvent includes a solvent that primarily or secondarily dissolves the components. The solvent may be selected from organic or inorganic solvents, with deionized water being the preferred primary solvent for the cosmetic composition.

[0077] The surfactants described herein also include emulsifiers, and in some preferred embodiments, the surfactants are preferably one or more of sodium stearoyl glutamate, MONTANOV™ L, Olivem 1000, and Emulgade® 165 CN.

[0078] In some preferred embodiments, the humectant comprises a polyol, including but not limited to one or more of glycerin, 1,2-hexanediol, and 1,3-propanediol.

[0079] In some preferred embodiments, the grease comprises one or more of Cetiol® Ultimate (INCI name: Undecane (and) Tridecane), isononyl isononanoate, and dimethyl silicone oil KF-96A-6T. Isonononyl isononanoate has a high spreading factor, with a spreading factor of 1400 mm. 2 It takes about 10 minutes to spread, feels quite refreshing, and is suitable as a base for refreshing cosmetics; Cetiol® Ultimate has a spreadability of 2500 mm. 2 / 10 min. This oil is easy to spread, non-greasy, easily absorbed, dry and smooth. It is suitable as a base for refreshing cosmetics, especially acne products, thereby reducing the oiliness of the product, making the product non-sticky, giving the skin a breathable feel, and not adding extra burden to acne-prone skin. When preparing lotions or creams, the oil selected is the ultra-refreshing Cetiol® Ultimate, which is especially suitable for acne-prone skin.

[0080] In some preferred embodiments, the preservative includes, but is not limited to, one or more of p-hydroxyacetophenone, p-hydroxybenzoic acid, potassium sorbate, benzyl alcohol, sodium benzoate, methyl paraben, phenoxyethanol, chlorphenesin, and benzoic acid, preferably including p-hydroxyacetophenone.

[0081] In some preferred embodiments, the chelating agent includes, but is not limited to, one or more of disodium EDTA, tetrasodium EDTA, dipotassium EDTA, tripotassium EDTA, and sodium phytate.

[0082] In some preferred embodiments, the pH adjuster includes, but is not limited to, one or more of arginine, sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, sodium citrate, succinic acid, disodium succinate, disodium hydrogen phosphate, sodium dihydrogen phosphate, aminomethylpropanol, and aminomethylpropanediol.

[0083] In some preferred embodiments, the solubilizer comprises one or more of PEG-60 hydrogenated castor oil, PEG-40 hydrogenated castor oil, and PPG-26-butanol polyether-26.

[0084] In some preferred embodiments, the cosmetic matrix includes glycerin, disodium EDTA, 1,2-hexanediol, p-hydroxyacetophenone, and 1,3-propanediol.

[0085] In some other preferred embodiments, the cosmetic matrix includes glycerin, sodium stearoyl glutamate, disodium EDTA, stearyl alcohol, dimethyl silicone oil kf-96A-6T, Cetiol® Ultimate, Emulgade® 165 CN, Montanov L, 1,2-hexanediol, p-hydroxyacetophenone, and 1,3-propanediol.

[0086] In some preferred embodiments, the cosmetic composition is formulated as follows: by weight percentage, it comprises 0.3-0.5% of *Sphingomonas sphingosine mononitrate* gum, 0.15-0.25% of *Sphingomonas sphingosine mononitrate* fermentation product extract, 2% of PG6 ACTIVE AA-GLY C, 2% of SKINPERF LWG, 0.25% of PCA zinc, 0.003% of Quaternium-73, 0.2% of SYMRELIEF® 100, 1.0% of SYMSITIVE® 1609, and 1% of SYMREPAIR® 100;

[0087] It also contains a cosmetic matrix comprising 3% glycerin, 0.02% disodium EDTA, 0.5% 1,2-hexanediol, 0.5% p-hydroxyacetophenone, and 3% 1,3-propanediol; it also includes a pH adjuster and a solubilizer, with the remainder being deionized water.

[0088] In some other preferred embodiments, the cosmetic composition is formulated as follows: by weight percentage, it comprises 0.3-0.45% of *Sphingomonas sphingosine mononitrate* gum, 0.15-0.22% of *Sphingomonas sphingosine mononitrate* fermentation product extract, 2% of PG6 ACTIVE AA-GLYC, 2% of SKINPERF LWG, 0.25% of PCA zinc, 0.002% of Quaternium-73, 0.2% of SYMRELIEF® 100, 1.2% of SYMSITIVE® 1609, and 1% of SYMREPAIR® 100;

[0089] It also contains a cosmetic matrix comprising 3% glycerin, 0.2% sodium stearoyl glutamate, 0.05% disodium EDTA, 3-5% stearyl alcohol, 1% dimethyl silicone oil KF-96A-6T, 5% Cetiol® Ultimate, 1% Emulgade® 165 CN, 1% Montanov L, 0.5% 1,2-hexanediol, 0.5% p-hydroxyacetophenone, and 3% 1,3-propanediol; it also includes a pH adjuster and fragrance, with the balance being deionized water.

[0090] The cosmetic composition of this embodiment is an acne-removing essence lotion or cream. It utilizes oils with a high spreadability and a very refreshing texture, resulting in a lotion or cream with good spreadability, fast absorption, and no stickiness after absorption, making it particularly suitable for acne-prone skin. Only KF-96A-6T and Cetiol® Ultimate are added to the oil, giving the product the characteristics of easy spreadability, non-greasy texture, easy absorption, and a dry feel. Combined with the thickening composition provided by this invention, the essence lotion or cream feels absorbed during application, leaving no residue and a relatively dry finish – something difficult to achieve with other similar acne-removing products. Both KF-96A-6T and Cetiol® Ultimate are refreshing oils. KF-96A-6T solves the problem of white streaks (white lines on the skin surface during application) caused by fatty alcohols, while Cetiol® Ultimate makes the prepared lotion or cream refreshing, breathable, and non-sticky, especially suitable for acne-removing products – something difficult to achieve with other similar products.

[0091] The dosage form of the cosmetic composition for acne treatment provided by this invention preferably includes aqueous solutions, emulsions, creams, or gels. Following the common classification of well-known and established products in the art, the cosmetic composition for acne treatment can be, for example, but not limited to, toners, lotions, serums, essences, emulsions, creams, essence creams, serums, gels, sprays, masks, serums, cream masks, or sheet masks.

[0092] According to another aspect of the present invention, the present invention also provides a method for preparing the above-mentioned cosmetic composition, comprising mixing the components according to the formulation amounts.

[0093] In some preferred embodiments, the preparation method includes: dissolving the antibacterial agent and the oil-controlling agent separately; dispersing the cosmetic thickening composition containing *Sphingomyelinum praecox* gum and *Sphingomonas sphingosine mononitrate* fermentation product extract in a solvent; then mixing the dissolved or dispersed systems; and finally adding and mixing the remaining components to obtain the cosmetic composition.

[0094] In some preferred embodiments, the preparation method includes: dissolving quaternary ammonium salt-73 in a polyol to obtain a first system, wherein the temperature of the polyol is preferably 60-75°C, more preferably 65-75°C; dissolving zinc PCA in a portion of the formulated amount of deionized water to obtain a second system, wherein the temperature of the portion of the formulated amount of deionized water is preferably 50-60°C; dispersing *Aspergillus oryzae* gum and *Sphingomonas sphingosine* fermentation product in the remaining amount of deionized water to obtain a third system; then mixing the first system, the second system, the third system, and the remaining components evenly to obtain a cosmetic composition, wherein preferably the *Aspergillus oryzae* gum and *Sphingomonas sphingosine* fermentation product extract evenly dispersed in the remaining amount of deionized water is heated to 82-88°C, homogenized for 5-10 minutes, cooled to 50-55°C, and then mixed with other components.

[0095] In some preferred embodiments, the preparation method includes the following steps:

[0096] Step (a): Quaternary ammonium salt-73 is mixed with 1,3-propanediol at 65~75°C until dissolved;

[0097] Step (b): Mix PCA zinc with deionized water at 50~60℃ until PCA zinc dissolves;

[0098] Step (c): Dissolve p-hydroxyacetophenone in 1,2-hexanediol at 55-60°C;

[0099] Step (d): Mix SYMRELIEF® 100, SYMSITIVE® 1609, SYMREPAIR® 100 and solubilizer;

[0100] Step (e): Disperse the Aspergillus oryzae gum and Sphingomonas fermentation product extract in the remaining amount of deionized water in the formulation;

[0101] Step (f): Heat the material from step (e) to 82~88°C, add glycerol and disodium EDTA, continue homogenization for 5~10 minutes, and then stir until homogeneous;

[0102] Step (g): When the material in step (f) is cooled to 50~55℃, the products in steps (a), (b), (c) and (d) are added, along with the encapsulated multiple fruit acids and the encapsulated azelaic acid; after adjusting the pH value, the mixture is stirred evenly.

[0103] In some preferred embodiments, the preparation method includes the following steps:

[0104] Step (a): Quaternary ammonium salt-73 is mixed with 1,3-propanediol at 65~75°C until dissolved;

[0105] Step (b): Mix PCA zinc with deionized water at 50~60℃ until PCA zinc dissolves;

[0106] Step (c): Dissolve p-hydroxyacetophenone in 1,2-hexanediol at 55-60°C;

[0107] Step (d): Mix SYMRELIEF® 100, SYMSITIVE® 1609, SYMREPAIR® 100 and solubilizer;

[0108] Step (e): Disperse the Aspergillus oryzae gum and Sphingomonas fermentation product extract in the remaining amount of deionized water in the formulation;

[0109] Step (f): Heat the material from step (e) to 82~88°C, add glycerol, disodium EDTA and sodium stearoyl glutamate, continue homogenization for 5~10 minutes, and then stir until homogeneous;

[0110] Step (g): Heat stearyl alcohol, dimethyl silicone oil kf-96A-6T, Cetiol® Ultimate, Emulgade® 165CN and Montanov L to 82~88°C until all components are completely dissolved;

[0111] Step (h): Add the product obtained in step (g) to step (f), homogenize, and then keep warm while stirring;

[0112] Step (i): When the product obtained in step (h) is cooled to 50~55°C, the products from steps (a), (b) and (c) are added, along with the encapsulated multiple fruit acids and encapsulated azelaic acid. After adjusting the pH, the mixture is stirred until homogeneous.

[0113] It is understandable that the above steps can be performed in sequence or out of sequence, or several steps can be performed simultaneously, such as steps (a) to (c), which can be performed simultaneously or in any order.

[0114] The technical solution and technical effects of the present invention will be further described below with reference to preferred embodiments.

[0115] Example 1

[0116] This embodiment provides a cosmetic composition, which can be used as a toner and contains the following components:

[0117] The product contains Caesalpinia spironosa gum, Sphingomonas fermentation product extract, encapsulated azelaic acid, encapsulated multiple fruit acids, zinc PCA, Quaternium-73, Symrelief® 100, Symsitive® 1609, and Symrelpair® 100; it also contains a cosmetic matrix including deionized water, glycerin, disodium EDTA, 1,2-hexanediol, p-hydroxyacetophenone, 1,3-propanediol, arginine, sodium hydroxide, and PEG-40 hydrogenated castor oil. The encapsulated azelaic acid is selected from PG6 Active AA-Gly C, and the encapsulated multiple fruit acids are selected from Skinperf LWG. The content of each component is shown in Table 1.

[0118] The preparation method of the cosmetic composition in this embodiment is as follows:

[0119] Step (a): Heat 1,3-propanediol to 65~75℃, add quaternary ammonium salt-73, and stir continuously until completely dissolved.

[0120] Step (b): Add 3% deionized water, heat to 50~60℃, then add zinc PCA, and stir continuously until completely dissolved.

[0121] Step (c): Heat 1,2-hexanediol to 55-60°C, then add p-hydroxyacetophenone and stir continuously until completely dissolved;

[0122] Step (d): Add SYMRELIEF® 100, SYMSITIVE® 1609 and SYMREPAIR® 100 to a beaker, then add an appropriate amount of PEG-40 hydrogenated castor oil and stir until homogeneous.

[0123] Step (e): Add the remaining deionized water from the formula to a beaker, turn on the homogenizer, add the *Sphingomonas sphingosine* fermentation product extract, homogenize for 8 minutes while stirring continuously until homogenized, and check until there are no particles agglomerating.

[0124] Step (f): Heat the material from step (e) to 82~88°C, add glycerol and disodium EDTA, continue homogenization for 5 minutes, and then stir until homogeneous.

[0125] Step (g): When the material in step (f) is cooled to 50~55℃, the products in steps (a), (b), (c) and (d) are added, along with the encapsulated multiple fruit acids and the encapsulated azelaic acid; the pH is adjusted to 4.5~5.5 using a small amount of water-pre-dissolved arginine or sodium hydroxide, stirred evenly and cooled to room temperature.

[0126] Example 2

[0127] This embodiment provides a cosmetic composition containing the same components as in Example 1, except that the component contents differ. The contents of each component are shown in Table 1. The preparation steps are the same as in Example 1, prepared according to the formulation amounts in Table 1. The cosmetic composition provided in this embodiment can be used as a serum. The main difference between this and Example 1 is that the composition in Example 2 has a higher viscosity.

[0128] Compare with Example 1

[0129] Compared with Example 1, Comparative Example 1 does not contain encapsulated multiple fruit acids, and the content of each component is shown in Table 1. The preparation steps are the same as in Example 1, except that step (g) does not include encapsulated multiple fruit acids, and is prepared according to the formula in Table 1.

[0130] Compare with Example 2

[0131] Compared to Example 1, Comparative Example 2 does not contain encapsulated azelaic acid, and the content of each component is shown in Table 1. The preparation steps are the same as in Example 1, except that step (g) does not contain encapsulated azelaic acid, and the formulation is prepared according to the amounts in Table 1.

[0132] Compare with Example 3

[0133] Compared with Example 1, Comparative Example 3 does not contain quaternary ammonium salt-73, and the contents of each component are shown in Table 1. The only difference between the preparation steps and those of Example 1 is that step (a) is not included, and the mixture is prepared according to the formulation amounts in Table 1.

[0134] Compare with Example 4

[0135] Compared with Example 1, Comparative Example 4 does not contain PCA zinc, and the contents of each component are shown in Table 1. The only difference between the preparation steps and Example 1 is that step (b) is not included, and the formula is prepared according to the amounts in Table 1.

[0136] Compare with Example 5

[0137] Compared with Example 1, Comparative Example 5 does not contain Sphingomonas fermentation product extract. The content of each component is shown in Table 1. The only difference between the preparation steps and Example 1 is that Sphingomonas fermentation product extract is not added in step (e), and the product is prepared according to the formula in Table 1.

[0138] Compare with Example 6

[0139] Compared with Example 1, Comparative Example 6 does not contain spiky guar gum. The content of each component is shown in Table 1. The only difference between the preparation steps and Example 1 is that spiky guar gum is not added in step (e), and the preparation is carried out according to the formula in Table 1.

[0140] Table 1. Content of each component in Examples 1-2 and Comparative Examples 1-6

[0141]

[0142] The content of each component in Table 1 is a percentage of the total mass of the cosmetic composition.

[0143] Example 3

[0144] This embodiment provides a cosmetic composition, which can be used as an essence lotion and contains the following components:

[0145] Spirogyra gum, Sphingomonas fermentation product extract, encapsulated azelaic acid, encapsulated multiple fruit acids, PCA zinc, quaternary ammonium salt-73, SYMRELIEF® 100, SYMSITIVE® 1609 and SYMREPAIR® 100;

[0146] It also contains a cosmetic matrix, which includes deionized water, glycerin, sodium stearoyl glutamate, disodium EDTA, stearyl alcohol, dimethyl silicone oil KF-96A-6T, Cetiol® Ultimate, Emulgade® 165 CN, Montanov L, arginine, 1,2-hexanediol, p-hydroxyacetophenone, 1,3-propanediol, PEG-40 hydrogenated castor oil, and fragrance. The encapsulated azelaic acid is selected from PG6 ACTIVE AA-GLY C, and the encapsulated multiple fruit acids are selected from SKINPERF LWG. The content of each component is shown in Table 2.

[0147] The preparation method of the cosmetic composition in this embodiment is as follows:

[0148] Step (a): Heat 1,3-propanediol to 65~75℃, add quaternary ammonium salt-73, and stir continuously until completely dissolved.

[0149] Step (b): Add 3% deionized water, heat to 50~60℃, then add zinc PCA, and stir continuously until completely dissolved.

[0150] Step (c): Heat 1,2-hexanediol to 55~60℃, then add p-hydroxyacetophenone and stir continuously until completely dissolved.

[0151] Step (d): Add SYMRELIEF® 100, SYMSITIVE® 1609 and SYMREPAIR® 100 to a beaker, then add an appropriate amount of PEG-40 hydrogenated castor oil and stir until homogeneous.

[0152] Step (e): Add the remaining deionized water from the formula to a beaker, turn on the homogenizer, add the *Sphingomyelinum spinosum* gum and *Sphingomonas* fermentation product extract, homogenize for 8-10 minutes with constant stirring until homogenized, and check for no particle agglomeration.

[0153] Step (f): Heat the material from step (e) to 82~88°C, add glycerol, disodium EDTA, and sodium stearoyl glutamate, continue homogenizing for 5 minutes, and then keep warm and stir until uniform.

[0154] Step (g): Heat stearyl alcohol, dimethyl silicone oil kf-96A-6T, Cetiol® Ultimate, Emulgade® 165CN and Montanov L to 82~88°C until completely dissolved and free of particles.

[0155] Step (h): Add the product obtained in step (g) to step (f), homogenize for 6 min, and keep warm and stir for 5 min.

[0156] Step (i): When the product obtained in step (h) is cooled to 50~55°C, the products in steps (a), (b) and (c) are added, along with the encapsulated multiple fruit acids and encapsulated azelaic acid, and arginine pre-dissolved in a small amount of water. The pH is adjusted to 4.5~5.5, stirred evenly, and cooled to room temperature.

[0157] Example 4

[0158] This embodiment provides a cosmetic composition containing the same components as in Example 3, except that the component contents differ from those in Example 3. The contents of each component are shown in Table 2. The preparation steps are the same as in Example 3, prepared according to the formulation amounts in Table 2. The cosmetic composition provided in this embodiment can be used as an essence cream.

[0159] Example 5

[0160] This embodiment provides a cosmetic composition whose components differ from those of Example 3 in that it does not contain Cetiol® Ultimate, but instead contains isononyl isononanoate. The preparation steps differ from those of Example 3 only in that step (g) does not add Cetiol® Ultimate, but instead adds isononyl isononanoate, prepared according to the formulation amounts in Table 2.

[0161] Example 6

[0162] This embodiment provides a cosmetic composition whose components differ from those of Example 3 in that it does not contain Montanov L, but contains OLIVEM 1000. The preparation steps differ from those of Example 3 only in that step (g) does not add Montanov L, but adds OLIVEM 1000, and is prepared according to the formulation amounts in Table 2.

[0163] Compare with Example 7

[0164] The difference between Comparative Example 7 and Example 3 is that the thickener does not contain Aspergillus oryzae gum and Sphingomonas fermentation product extract, but uses sodium polyacrylamide dimethyl taurate. The only difference between the preparation steps and Example 3 is step (e) homogenizing sodium polyacrylamide dimethyl taurate according to the formulation in Table 2.

[0165] Compare with Example 8

[0166] The difference between Comparative Example 8 and Example 3 is that the thickener does not contain Aspergillus oryzae gum and Sphingomonas fermentation product extract, but instead uses polyacrylate cross-linked polymer-6. The only difference between the preparation steps and Example 3 is that in step (e), the polyacrylate cross-linked polymer-6 is homogenized and prepared according to the formulation amount in Table 2.

[0167] Table 2. Content of each component in Examples 3-6 and Control Examples 7-8

[0168]

[0169] Example of effect 1

[0170] Skin feel test and efficacy evaluation test:

[0171] The study included 32 participants, with 2 lost to follow-up, leaving 30 valid participants. The participants were healthy Asian individuals with no restrictions on skin type, but with acne-like skin lesions.

[0172] Test sampling time points: D0 (before sample use) and D7 (7 days after use); usage method: once in the morning and once in the evening; evaluation method: questionnaire survey.

[0173] (1) The evaluation indicators for Control Examples 1-4 and Example 1 were: soothing / non-irritating properties, oil control effect, acne improvement, and skin feel satisfaction. Skin feel tests and efficacy evaluation tests were conducted on Control Examples 1-4 and Example 1. The number of people who were very satisfied or relatively satisfied with the above four test indicators was counted; those who considered the effect to be average or ineffective were considered to have no effect and were not counted. The test results are shown in Table 3:

[0174] Table 3 shows the skin feel test and efficacy evaluation test of Comparative Examples 1-4 and Example 1.

[0175] Satisfied respondents (30 valid respondents)

[0176]

[0177] The experiment found that the test group was quite satisfied with the soothing / non-irritating properties, oil control effect, acne improvement, and skin feel of Example 1. As can be seen from the results in Table 3, the compositions of the present invention have a synergistic effect; through the synergistic action between the compositions, they exhibit significant acne-reducing, oil-controlling, and more soothing / non-irritating effects.

[0178] (2) The skin feel of Control Example 8, Example 3, Example 5 and Example 6 was evaluated using a scoring system, with scores ranging from 1 to 5. Higher scores indicate better spreadability, better smoothness, faster absorption, less stickiness during application, and less stickiness after application. The average value of the obtained data was taken, and the data analysis is shown in Table 4.

[0179] Table 4 shows the skin feel evaluation results for Comparative Example 8, Example 3, Example 5, and Example 6.

[0180]

[0181] The experiment found that Control Example 8 was relatively sticky during and after application; the refreshing feeling and absorption of Examples 5 and 6 were significantly slower during application; Table 4 shows that the test group was very satisfied with the spreadability, smoothness, absorption speed, stickiness during application, and stickiness after application of Example 3.

[0182] Example 2

[0183] Efficacy test:

[0184] The referenced test methods are: "T / CNMIA 0012-2020 Clinical Evaluation Standard for Acne-Removing Efficacy Skin Care Products", "T / TDCA 004-2021 Test Method for Acne-Removing Efficacy of Cosmetics", "T / ZHCA002-2018 Test Method for Oil Control Efficacy of Cosmetics", "QB / T 4256-2011 Guidelines for Evaluating Moisturizing Efficacy of Cosmetics" and "T / ZHCA003-2018 Test Method for Cosmetics' Influence on Transepidermal Water Loss".

[0185] All samples passed pricking and patch tests before testing, indicating that the tested products are very gentle.

[0186] The samples were tested for skin stratum corneum moisture content, transepidermal water loss, skin luster, skin oil content, facial pore area ratio, facial red area a value, and number of facial acne.

[0187] Moisturizing: Skin stratum corneum moisture content; the higher the test value, the higher the moisture content. Soothing and repairing: Transepidermal water loss; the lower the test value, the better the skin barrier function. Oil control: Skin oil content; the lower the test value, the less oil secretion. Acne treatment: The fewer pimples on the face, the better. Facial redness a value; the lower the test value, the less redness of the skin.

[0188] The relevant testing instruments are as follows:

[0189] 1) Moisture content test: The skin moisture content was measured at each test point using the Comeometer® CM 825 probe, and each test area was tested three times.

[0190] 2) Transepidermal water loss test: The transepidermal water loss (TEWL) value (g / m³) was measured at each test time point using the Tewameter® TM Hex probe. 2 / h), each test area is tested three times.

[0191] 3) Skin oil content test: The skin oil content was measured at each test point using the Sebumeter® SM 815 probe, and each test area was tested three times.

[0192] 4) Skin erythema index a value: The skin image acquisition instrument VISIA-CR was used to capture standard white light and UV light standard images, and the Image-Pro Plus analysis system was used to analyze the proportion of facial pore area and the red area a value.

[0193] 5) Acne area percentage: Images of the subjects were captured using the VISIA-CR skin image acquisition instrument, and the Image-Pro Plus analysis system was used to analyze the acne area percentage.

[0194] If, after using the product, any change in any parameter of moisturizing, repairing, oil control, or acne removal is significantly improved compared to before the subject used the product (P<0.05), then the test product is considered to have moisturizing, soothing, repairing, or acne-removing effects.

[0195] The efficacy test results of the cosmetic composition provided in Example 3 are shown in Table 5. The red zone images collected on days 0, 14, and 28 of the test are shown below. Figure 1 As shown, Figure 1 In the image, A is the red zone acquisition image at D0, B is the red zone acquisition image at D14, and C is the red zone acquisition image at D28.

[0196] Table 5 Results of efficacy tests in Example 3

[0197]

[0198] As shown in Table 5, after 14 days and 28 days of using the product of Example 3, the skin stratum corneum moisture content in the test area of ​​the subjects' faces significantly increased; the transepidermal water loss rate significantly decreased; the skin oil content significantly decreased; the skin erythema index (α) significantly decreased; and the proportion of acne area significantly decreased. Figure 1It can be seen that using the product in Case Study 3 can effectively improve acne, reduce the area of ​​acne, and improve inflammation. The above experimental results demonstrate that the product in Case Study 3 has moisturizing, soothing, repairing, oil-controlling, and acne-reducing effects.

[0199] Example 3: Stability Test

[0200] The stability test was conducted as follows: Samples were placed in incubators at -18℃, 4℃, 40℃, 45℃, and subjected to thermal cycling. Samples were removed from each temperature at 1, 2, 4, 8, and 12 weeks to observe for any abnormalities. At any of the above times and temperatures, if the product exhibited precipitation, stratification, discoloration, off-odor, or abnormal viscosity changes (exceeding 50% compared to the initial value), it was recorded as a "failure." All other abnormalities were recorded as "normal." The test results are shown in Table 6 and... Figure 2 As shown:

[0201] Table 6 Stability Test Results

[0202]

[0203] As can be seen from the experimental results in Table 6, the cosmetic composition provided in this embodiment has good stability. Under conditions ranging from -18℃ to 45℃ and thermal cycling, there were no defects such as precipitation, stratification, discoloration, odor change, or abnormal viscosity changes. In contrast, Control Example 7 showed stratification during high-temperature testing, and Control Example 8 exhibited a severe decrease in viscosity. All examples 1-6 showed no abnormalities in stability testing. Figure 2 The stability test images show that the left image is the cosmetic composition provided in Example 3, and the right image is the control example 7. It can be seen that the control example 7 shows stratification at high temperature.

[0204] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A cosmetic composition for treating acne, characterized in that, By weight percentage, it contains 0.3-0.5% *Sphingomonas sphingosine mononitrate* gum, 0.15-0.25% *Sphingomonas sphingosine mononitrate* fermentation product extract, 4-10% exfoliating agent, 0.25-1.0% oil-controlling agent, 0.002-0.005% antibacterial agent, 0.2-2.0% anti-inflammatory agent, and 1-2.0% soothing and repairing agent; the remainder is cosmetic base. The stripping agent comprises PG6 ACTIVE AA-GLY C and SKINPERF LWG; The anti-inflammatory agents include SYMRELIEF® 100 and SYMSITIVE® 1609; The soothing and repairing agents include SYMREPAIR® 100; The oil-controlling agent includes zinc PCA; The antibacterial agent includes quaternary ammonium salt-73; The pH of the cosmetic composition for acne treatment is 4.5 to 5.

5.

2. The cosmetic composition according to claim 1, characterized in that, The oil-controlling agent also includes one or more of plankton extracts and spider lily extracts.

3. The cosmetic composition according to claim 1, characterized in that, The antibacterial agent also includes one or more of octanoylglycine and white willow bark extract.

4. The cosmetic composition according to claim 1, characterized in that, The anti-inflammatory agents also include one or more of panthenol and licorice derivatives.

5. The cosmetic composition according to claim 4, characterized in that, The licorice derivatives include dipotassium glycyrrhizate.

6. The cosmetic composition according to claim 1, characterized in that, The soothing and repairing agent also includes one or more of centella asiatica extract and ceramides.

7. The cosmetic composition according to claim 6, characterized in that, The Centella asiatica extract includes asiaticoside.

8. The cosmetic composition according to claim 1, characterized in that, The cosmetic composition includes *Sphingomonas sphingosine mononitrate* fermentation product extract, PG6 ACTIVE AA-GLY C, SKINPERF LWG, PCA zinc, quaternary ammonium salt-73, SYMRELIEF® 100, SYMSITIVE® 1609, and SYMREPAIR® 100; The cosmetic composition, by weight percentage, comprises 0.3-0.5% of *Sphingomonas sphingosine mononitrate* gum, 0.15-0.25% of *Sphingomonas sphingosine mononitrate* fermentation product extract, 2% of PG6 ACTIVE AA-GLY C, 2% of SKINPERF LWG, 0.25% of PCA zinc, 0.002-0.003% of Quaternium-73, 0.2% of SYMRELIEF® 100, 1.0-2.0% of SYMSITIVE® 1609, and 1% of SYMREPAIR® 100; the balance being a cosmetic base.

9. The cosmetic composition according to claim 1, characterized in that, The cosmetic matrix includes one or more of the following: solvent, surfactant, solubilizer, thickener, skin conditioner, oil, preservative, chelating agent, pH adjuster, and fragrance.

10. The cosmetic composition according to claim 9, characterized in that, The surfactant includes an emulsifier.

11. The cosmetic composition according to claim 10, characterized in that, The surfactant includes one or more of sodium stearoyl glutamate, MONTANOV™ L, OLIVEM 1000, and Emulgade® 165 CN.

12. The cosmetic composition according to claim 9, characterized in that, The skin conditioning agent includes a moisturizer.

13. The cosmetic composition according to claim 12, characterized in that, The moisturizer includes polyols.

14. The cosmetic composition according to claim 13, characterized in that, The polyols include one or more of glycerol, 1,2-hexanediol, and 1,3-propanediol.

15. The cosmetic composition according to claim 9, characterized in that, The grease includes one or more of Cetiol® Ultimate, isononyl isononanoate, and dimethyl silicone oil kf-96A-6T.

16. The cosmetic composition according to claim 9, characterized in that, The preservatives include one or more of p-hydroxyacetophenone, p-hydroxybenzoic acid, potassium sorbate, benzyl alcohol, sodium benzoate, methyl p-hydroxybenzoate, phenoxyethanol, chlorphenesin, and benzoic acid.

17. The cosmetic composition according to claim 9, characterized in that, The chelating agent includes one or more of disodium EDTA, tetrasodium EDTA, dipotassium EDTA, tripotassium EDTA, and sodium phytate.

18. The cosmetic composition according to claim 9, characterized in that, The pH adjuster includes one or more of arginine, sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, sodium citrate, succinic acid, disodium succinate, disodium hydrogen phosphate, sodium dihydrogen phosphate, aminomethylpropanol, and aminomethylpropanediol.

19. The cosmetic composition according to claim 9, characterized in that, The solubilizer includes one or more of PEG-60 hydrogenated castor oil, PEG-40 hydrogenated castor oil, and PPG-26-butanol polyether-26.

20. The cosmetic composition according to claim 9, characterized in that, The solvents include organic solvents and / or inorganic solvents.

21. The cosmetic composition according to claim 9, characterized in that, The solvent includes deionized water.

22. The cosmetic composition according to claim 9, characterized in that, The cosmetic matrix includes glycerin, disodium EDTA, 1,2-hexanediol, p-hydroxyacetophenone, and 1,3-propanediol.

23. The cosmetic composition according to claim 9, characterized in that, The cosmetic matrix includes glycerin, sodium stearoyl glutamate, disodium EDTA, stearyl alcohol, dimethyl silicone oil kf-96A-6T, Cetiol® Ultimate, Emulgade® 165 CN, Montanov L, 1,2-hexanediol, p-hydroxyacetophenone, and 1,3-propanediol.

24. The cosmetic composition according to claim 1, characterized in that, The cosmetic composition is an aqueous solution, emulsion, cream, or gel.

25. The cosmetic composition according to claim 24, characterized in that, The cosmetic composition is a toner, lotion, cream, gel, serum, spray, or mask.

26. The cosmetic composition according to claim 25, characterized in that, The toner includes astringent or essence.

27. The cosmetic composition according to claim 25, characterized in that, The emulsion includes an essence emulsion.

28. The cosmetic composition according to claim 25, characterized in that, The cream includes a serum cream.

29. The cosmetic composition according to claim 25, characterized in that, The face mask includes a cream mask or a sheet mask.

30. The cosmetic composition according to any one of claims 1-29, characterized in that, The product, by weight percentage, includes 0.3-0.5% *Sphingomonas sphingosine mononitrate* fermentation product extract, 0.15-0.25% PG6 ACTIVE AA-GLY C, 2% SKINPERF LWG, 0.25% PCA zinc, 0.003% Quaternium-73, 0.2% SYMRELIEF® 100, 1.0% SYMSITIVE® 1609, and 1% SYMREPAIR® 100. It also contains a cosmetic matrix comprising 3% glycerin, 0.02% disodium EDTA, 0.5% 1,2-hexanediol, 0.5% p-hydroxyacetophenone, and 3% 1,3-propanediol; it also includes a pH adjuster and a solubilizer, with the remainder being deionized water.

31. The cosmetic composition according to any one of claims 1-29, characterized in that, By weight percentage, it contains 0.3-0.45% *Sphingomonas sphingosine mononitrate* gum, 0.15-0.22% *Sphingomonas sphingosine mononitrate* fermentation product extract, 2% PG6 ACTIVE AA-GLYC, 2% SKINPERF LWG, 0.25% PCA zinc, 0.002% Quaternium-73, 0.2% SYMRELIEF® 100, 1.2% SYMSITIVE® 1609, and 1% SYMREPAIR® 100; It also contains a cosmetic matrix comprising 3% glycerin, 0.2% sodium stearoyl glutamate, 0.05% disodium EDTA, 3-5% stearyl alcohol, 1% dimethyl silicone oil KF-96A-6T, 5% Cetiol® Ultimate, 1% Emulgade® 165CN, 1% Montanov L, 0.5% 1,2-hexanediol, 0.5% p-hydroxyacetophenone, and 3% 1,3-propanediol. It also includes pH adjusters and flavorings, with the remainder being deionized water.

32. A method for preparing the cosmetic composition according to any one of claims 1-31, characterized in that, This includes mixing the components according to the formula.

33. The preparation method according to claim 32, characterized in that, The preparation method includes: dissolving the antibacterial agent and the oil-controlling agent separately; dispersing the extracts of Aspergillus oryzae and Sphingomonas fermentation products in a solvent; then mixing the dissolved or dispersed systems; and finally adding the remaining components and mixing them evenly to obtain the cosmetic composition.

34. The preparation method according to claim 33, characterized in that, The preparation method includes: Quaternary ammonium salt-73 was dissolved in a polyol to obtain the first system; zinc PCA was dissolved in a portion of the prescribed amount of deionized water to obtain the second system; and the fermentation products of Astrophytum esculentum and Sphingomonas were dispersed in the remaining amount of deionized water to obtain the third system. The first system, the second system, the third system, and the remaining ingredients are mixed evenly to obtain the cosmetic composition.

35. The preparation method according to claim 34, characterized in that, The first system was obtained by dissolving quaternary ammonium salt-73 in a polyol at 60-75°C.

36. The preparation method according to claim 34, characterized in that, Dissolve a portion of the formulated amount of deionized water at 50-60°C to obtain the second system.

37. The preparation method according to claim 34, characterized in that, The *Sphingomyelia esculenta* gum and *Sphingomonas sphingosine monophosphate* fermentation product extract, which are uniformly dispersed in the remaining deionized water, are heated to 82-88°C, homogenized for 5-10 minutes, cooled to 50-55°C, and then mixed with other ingredients.

38. A method for preparing the cosmetic composition according to any one of claims 32-37, characterized in that, include: Step (a): Quaternary ammonium salt-73 is mixed with 1,3-propanediol at 65~75°C until dissolved; Step (b): Mix PCA zinc with deionized water at 50~60℃ until PCA zinc dissolves; Step (c): Dissolve p-hydroxyacetophenone in 1,2-hexanediol at 55-60°C; Step (d): Mix SYMRELIEF® 100, SYMSITIVE® 1609, SYMREPAIR® 100 and solubilizer; Step (e): Disperse the Aspergillus oryzae gum and Sphingomonas fermentation product extract in the remaining amount of deionized water in the formulation; Step (f): Heat the material from step (e) to 82~88°C, add glycerol and disodium EDTA, continue homogenization for 5~10 minutes, and then stir until homogeneous; Step (g): When the material in step (f) is cooled to 50~55℃, the products from steps (a), (b), (c) and (d) are added, along with PG6 ACTIVE AA-GLY C and SKINPERF LWG; after adjusting the pH value, the mixture is stirred evenly.

39. A method for preparing the cosmetic composition according to any one of claims 32-37, characterized in that, include: Step (a): Quaternary ammonium salt-73 is mixed with 1,3-propanediol at 65~75°C until dissolved; Step (b): Mix PCA zinc with deionized water at 50~60℃ until PCA zinc dissolves; Step (c): Dissolve p-hydroxyacetophenone in 1,2-hexanediol at 55-60°C; Step (d): Mix SYMRELIEF® 100, SYMSITIVE® 1609, SYMREPAIR® 100 and solubilizer; Step (e): Disperse the Aspergillus oryzae gum and Sphingomonas fermentation product extract in the remaining amount of deionized water in the formulation; Step (f): Heat the material from step (e) to 82~88°C, add glycerol, disodium EDTA and sodium stearoyl glutamate, continue homogenization for 5~10 minutes, and then stir until homogeneous; Step (g): Heat stearyl alcohol, dimethyl silicone oil kf-96A-6T, Cetiol® Ultimate, Emulgade® 165 CN and Montanov L to 82~88°C until all components are completely dissolved; Step (h): Add the product obtained in step (g) to step (f), homogenize, and then keep warm while stirring; Step (i): When the product obtained in step (h) is cooled to 50~55°C, the products from steps (a), (b), (c) and (d) are added, along with PG6 ACTIVE AA-GLY C and SKINPERF LWG. After adjusting the pH, the mixture is stirred until homogeneous.

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