A traditional Chinese medicine composition for treating skin lesions and scars, and its preparation method and application

Abstract

The present invention relates to the technical field of traditional Chinese medicine, and provides a Chinese medicine composition for treating skin lesions and scars, and a preparation method and application thereof, which is mainly used to treat skin lesions and scars caused by carbuncle and ulcer. The Chinese medicine composition of the present invention comprises the following raw materials: Vaccaria segetalis, Astragalus membranaceus, Bletilla striata, Morus alba bark, Angelica dahurica, White Ampelopsis Root, Dictamni Cortex, Rhizoma Cyperi, Rhizoma Bletillae, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bletilla striata Rhizoma, Bark of Bombyx batryticatus, Magnolia officinalis, Pueraria root, Eucommia bark, Dipsacus asper, Smilax glabra, Honeysuckle vine, Chuanxiong, Angelica sinensis, Ephedra sinica, and Cinnamomum cassia. The Chinese medicine composition of the present invention has the effects of dispelling wind and relieving itching, relieving swelling and relieving pain, promoting pus and detoxifying, and reducing color and eliminating scars. It is mainly used to treat skin lesions and scars caused by carbuncle and ulcer, and is significantly effective for treating skin ulcers, swellings, and furuncles. It also treats pruritus caused by deep infected wounds and psoriasis lesions, and reduces the use of antibiotics.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating skin lesions and scars, and a preparation method and application thereof. Background Art

[0002] The skin is the largest organ in the human body, performing a range of physiological functions, including respiration, sensation, protection, absorption, secretion, excretion, temperature regulation, and metabolism. It also serves as a crucial barrier to maintaining homeostasis. The skin's tissue repair process is generally divided into four phases: hemostasis, inflammation, proliferation, and tissue remodeling. Scars are a general term for the morphological and histopathological changes in normal skin tissue caused by various traumatic events. Modern medicine believes that scar formation is complex and multifaceted, and its formation mechanism is not fully understood. Macroscopic factors include individual demographic characteristics of the patient, such as ethnicity, gender, and age, as well as external factors such as the severity of the injury and surgical incision. Microscopically, cells involved include fibroblasts, myofibroblasts, mast cells, and neutrophils. Cytokines involved include transforming growth factor-β, tumor necrosis factor-α, and vascular endothelial growth factor. The extracellular matrix, including the interactions of components such as collagen metabolism and abnormal arrangement, and alterations in glycosaminoglycans, is involved. Three-dimensional aspects of tissue spatial structure, such as the spatial regulatory networks formed between repair cells, may all contribute to the entire scar formation process. Discomfort such as itching, pain, redness, allergies, and impaired skin activity at the wound site can occur. Some individuals may even experience enlarged scars and recurrent infections, leading to cancer. Keloid is a pathological scar tissue that is formed secondary to skin trauma or spontaneously due to excessive growth. The lesion exceeds the scope of the original skin damage and continues to grow. It appears as a nodular, cord-like or sheet-like mass-like tissue that is higher than the skin, hard, tough and congested, and is often accompanied by pain and itching.

[0003] Currently, Western medicine lacks effective treatments for keloids. Treatments such as photodynamic therapy, surgical excision, radiotherapy, and glucocorticoid injections offer significant short-term benefits, but long-term recurrence rates are high and difficult to control. Traditional Chinese medicine (TCM) believes that scar formation is caused by internal accumulation of dampness and turbidity, coupled with external invasion by poisonous insects, fire, and insect toxicity. These damage the skin, leading to disharmony between the Ying and Wei systems and accumulation of dampness and toxicity. Over time, this leads to obstruction of the meridians and stagnation of Qi and blood. Historically, physicians have adhered to the principle of "cutting away the hardened, attacking the lingering, dispersing the knotted, and removing the conquered." Their primary approach to scar treatment has been to activate blood circulation, resolve blood stasis, and clear away heat, resolve phlegm, and soften hard masses. Commonly used herbs include Salvia miltiorrhiza, Gallnut, Scolopendra, Chuanxiong, Angelica sinensis, Curcuma zedoaria, Lithospermum officinale, Safflower, Black vinegar, Borneolum, Trillium, Sophora flavescens, Pangolin, Angelica dahurica, Pinellia ternata, and Stephania tetrandra, but these have been ineffective. Therefore, in-depth research on skin lesions and scars caused by carbuncles and ulcers within the context of TCM is warranted. Summary of the Invention

[0004] In view of this, the object of the present invention is to provide a traditional Chinese medicine composition for treating skin lesions and scars, which can effectively treat skin ulcers, swellings, furuncles, and carbuncles, and can also treat deep infected wounds and pruritus of psoriasis lesions, reduce the use of antibiotics, and has high safety.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a traditional Chinese medicine composition for treating skin lesions and scars. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-60 parts of fenugreek, 20-60 parts of astragalus, 3-10 parts of bletilla striata, 3-10 parts of mulberry root bark, 3-10 parts of angelica dahurica, 3-10 parts of white ampelopsis, 3-10 parts of dittany bark, 3-10 parts of white mulberry, 3-10 parts of white mulberry, 3-10 parts of processed white aconite, 3-10 parts of bombyx batryticatus, 3-10 parts of magnolia bark, 3-10 parts of kudzu root, 3-10 parts of eucommia bark, 3-10 parts of dipsaccharum officinale, 3-10 parts of smilax glabra, 3-10 parts of honeysuckle vine, 3-10 parts of ligusticum chuanxiong, 3-10 parts of angelica sinensis, 3-10 parts of ephedra, and 3-10 parts of cassia twig.

[0007] The invention provides an oily agent for treating skin lesions and scars caused by carbuncle ulcers. The oily agent comprises the traditional Chinese medicine composition and an organic oil solvent.

[0008] Preferably, the organic oil solvent is plant-extracted oil or mineral oil.

[0009] The present invention provides a method for preparing the oil preparation, comprising soaking raw materials of a traditional Chinese medicine composition in an organic oil solvent for 15 to 50 days to obtain a mixture, boiling the mixture with high heat, and continuing to boil with high heat for 3 to 5 hours until oil drops form beads, filtering out the medicinal residue, and obtaining the oil preparation.

[0010] Preferably, the mass ratio of the raw materials of the traditional Chinese medicine composition to the organic oil solvent is 0.5 to 1:1.

[0011] The present invention also provides an ointment for treating skin lesions and scars, wherein the ointment comprises the traditional Chinese medicine composition.

[0012] The invention provides a method for preparing the ointment, comprising the steps of: soaking the raw materials of the traditional Chinese medicine composition in an organic oil solvent for 15 to 50 days to obtain a mixture; boiling the mixture with high heat, continuing to boil the mixture with high heat for 3 to 5 hours until the oil drops into beads, filtering out the medicinal residues, and obtaining an oil solution; heating the oil solution to boiling again, pouring it into beeswax and insect wax, and fully stirring to obtain the ointment.

[0013] Preferably, the mass ratio of the raw materials of the traditional Chinese medicine composition to the organic oil solvent is 0.5 to 1:1.

[0014] Preferably, the oil, beeswax and insect wax are configured in a weight ratio of 5-15:0.5-1:0.5-1.

[0015] The present invention also provides a use of the traditional Chinese medicine composition, the oil, the oil obtained by the preparation method, the ointment, or the ointment obtained by the preparation method in preparing a medicine for treating skin lesions and scars caused by carbuncles and ulcers.

[0016] Compared with the prior art, the present invention has the following technical effects:

[0017] (1) Scars are mostly caused by damage to Yang Qi, loss of Qi and blood temperature, cold stagnation and damage to Yang, inability to transform body fluids, and accumulation of phlegm. Phlegm accumulation over time becomes toxic. The Chinese medicine composition of the present invention uses Astragalus and Vaccaria as the main drugs, with Astragalus used as the main drug to replenish Qi, and the amount is large; Vaccaria is mainly used to stop bleeding from wounds, promote blood circulation and dredge menstruation; Morus alba is mainly used to promote diuresis and reduce swelling; Magnolia officinalis is mainly used to dry dampness and eliminate phlegm; Ephedra opens the pores, and cinnamon twigs relieve cold stagnation. The combination of these drugs has the effects of dispelling wind and relieving itching, clearing pus and detoxifying, reducing color and eliminating scars, and can effectively treat skin ulcers, swellings, furuncles, and deep wounds with infection. In wound treatment, it can reduce the need for antibiotics. The Chinese medicine composition of the present invention has the effect of moisturizing and relieving itching, and reducing skin lesion erythema after use on psoriasis skin lesions.

[0018] (2) The present invention takes the wound healing process as the starting point, starting from the factors affecting scar formation, early prevention and treatment and selection of correct drug treatment are of great significance for preventing the recurrence of pathological scars and improving the formation of post-traumatic scars. During the inflammatory phase, proliferation phase and remodeling phase, the formation of scars is inhibited by reducing the inflammatory response and promoting tissue regeneration. The healing speed and quality are given equal importance, the healing speed is properly regulated, and granulation growth and re-epithelialization are carried out simultaneously, which has the advantages of good efficacy and no side effects. At the same time, the Chinese medicine composition of the present invention is mainly composed of plant medicines, which is more cost-effective than the existing improved carbuncle oil preparation involving multiple animal medicines. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a physical picture of the Chinese medicine composition oil of the present invention;

[0020] Figure 2 This is a comparison diagram of the Chinese medicine composition oil of the present invention and the carbuncle oil; in the figure: the right side is the Chinese medicine composition oil of the present invention, and the left side is the carbuncle oil;

[0021] Figure 3 This is the recovery effect of the Chinese medicine composition oil of the present invention on the patient in Case 1;

[0022] Figure 4 This is the recovery effect of the Chinese medicine composition oil of the present invention on the patient in Case 2;

[0023] Figure 5 This is the recovery effect of the Chinese medicine composition oil of the present invention on the patient in Case 3;

[0024] Figure 6 This is the recovery effect of the Chinese medicine composition oil of the present invention on the patient in Case 4;

[0025] Figure 7 This is the recovery effect of the Chinese medicine composition oil of the present invention on the patient in Case 5;

[0026] Figure 8 The recovery effect of the Chinese medicine composition oil of the present invention on the patient in Case 6;

[0027] Figure 9 This is the recovery effect of the patient in Case 7 using the Chinese medicine composition oil of the present invention. DETAILED DESCRIPTION

[0028] The invention provides a traditional Chinese medicine composition for treating skin lesions and scars caused by carbuncle and ulcer. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-60 parts of fenugreek, 20-60 parts of astragalus, 3-10 parts of bletilla striata, 3-10 parts of mulberry root bark, 3-10 parts of angelica dahurica, 3-10 parts of white ampelopsis, 3-10 parts of white dandelion, 3-10 parts of white mulberry bark, 3-10 parts of white mulberry, 3-10 parts of white mulberry, 3-10 parts of processed white aconite, 3-10 parts of bombyx batryticatus, 3-10 parts of magnolia bark, 3-10 parts of kudzu root, 3-10 parts of eucommia bark, 3-10 parts of dipsaccharum officinale, 3-10 parts of wild smilax, 3-10 parts of honeysuckle vine, 3-10 parts of ligusticum chuanxiong, 3-10 parts of angelica sinensis, 3-10 parts of ephedra, and 3-10 parts of cassia twig. Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-50 parts of fenugreek, 25-50 parts of astragalus, 4-8 parts of bletilla striata, 4-8 parts of mulberry root bark, 4-8 parts of angelica dahurica, 4-8 parts of white ampelopsis, 4-8 parts of white dandelion, 4-8 parts of white mulberry bark, 4-8 parts of white mulberry, 4-8 parts of processed white aconite, 4-8 parts of bombyx batryticatus, 4-8 parts of Magnolia officinalis, 4-8 parts of kudzu root, 4-8 parts of eucommia, 4-8 parts of dipsaccharum officinale, 4-8 parts of wild smilax, 4-8 parts of honeysuckle vine, 4-8 parts of ligusticum chuanxiong, 4-8 parts of angelica sinensis, 4-8 parts of ephedra, and 4-8 parts of cassia twig. More preferably, the Chinese medicine composition comprises the following raw materials in parts by weight: 30 parts of fenugreek, 30 parts of astragalus, 5 parts of bletilla striata, 5 parts of mulberry root bark, 5 parts of angelica dahurica, 5 parts of white ampelopsis, 5 parts of white mulberry bark, 5 parts of white mulberry, 5 parts of processed white aconite, 5 parts of bombyx batryticatus, 5 parts of Magnolia officinalis, 5 parts of Pueraria root, 5 parts of Eucommia bark, 5 parts of Dipsacus asper, 5 parts of Smilax glabra, 5 parts of honeysuckle vine, 5 parts of Chuanxiong, 5 parts of angelica, 5 parts of ephedra, and 5 parts of cinnamon twig.

[0029] In the present invention, Vaccaria segetalis, the dried mature seeds of the Caryophyllaceae family, are bitter in taste, neutral in nature, and enter the liver and stomach meridians. They have the effects of promoting blood circulation and menstruation, promoting lactation and reducing swelling, and promoting diuresis and relieving stranguria. Combined with Astragalus and Chinese Angelica, the present invention has the effects of promoting blood circulation, eliminating carbuncle, reducing swelling and relieving pain.

[0030] Astragalus root is sweet and slightly warm in nature, and enters the lung and spleen meridians. It has the effects of tonifying qi and raising yang, strengthening the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid production and nourishing blood, relieving stagnation and relieving numbness, expelling toxins and pus, and healing sores and promoting tissue regeneration.

[0031] Bletilla striata (Bletilla striata), a member of the Orchidaceae family, is a dried tuber with a bitter, sweet, and astringent taste and a slightly cold nature. It enters the Lung, Liver, and Stomach meridians. It has astringent, hemostatic, and tissue-stimulating properties. It should not be used with Aconite or Linderae striata. Bletilla striata is astringent and hemostatic, primarily entering the Lung and Stomach meridians, and can reduce swelling and promote tissue growth. It is suitable for treating sores, carbuncles, chapped skin, and burns.

[0032] Mulberry root bark, Moraceae; the dried root bark of the mulberry tree. It is sweet in taste, cold in nature, and enters the Lung meridian. It has lung-clearing, asthma-relieving, diuretic, and swelling-reducing properties, with a predominance of diuretic properties. The total flavonoids in the bark have anti-inflammatory and analgesic effects, and the aqueous extract has hypoglycemic properties. Mulberry root bark also has antihypertensive, immunomodulatory, antiviral, anti-tumor, antioxidant, anti-hypoxic, and anti-aging properties.

[0033] Angelica dahurica (Apiaceae); the dried root. It is pungent and warm in nature. It enters the stomach, large intestine, and lung meridians. It has the effects of dispelling cold, expelling wind and relieving pain, clearing the nasal passages, drying dampness and relieving leukorrhea, and reducing swelling and draining pus.

[0034] The dried root of Bletilla striata (Vitaceae) is bitter and cold in nature. It enters the Heart and Stomach meridians. It has the effects of clearing heat and detoxifying, dissolving carbuncle and stagnation, and healing sores and promoting tissue regeneration.

[0035] The dried root bark of Dictamnus dasyphylla (Rutaceae) is bitter and cold in nature, entering the spleen, stomach, and bladder meridians. It has the effects of clearing heat and dampness, dispelling wind and detoxifying.

[0036] The dried root and rhizome of Baiwei (Asclepiadaceae) are bitter, salty, and cold in nature. They enter the stomach, liver, and kidney meridians and enter the blood. They have the effects of clearing heat and cooling blood, promoting diuresis and relieving stranguria, and detoxifying and treating sores.

[0037] Prepared white aconite root, a member of the Araceae family; the dried tuber of the plant Unicornia hornulata. It is pungent, warm, and toxic. It enters the stomach and liver meridians. It has the effects of dispelling wind and phlegm, calming convulsions, detoxifying, dispersing nodules, and relieving pain. External application of prepared white aconite root can treat scrofula, phlegm nodules, and snake bites.

[0038] Bombyx batryticatus (Bombyx batryticatus), a member of the Bombycidae family, is the dried remains of silkworm larvae infected with Beauveria bassiana, resulting in their death. It has a salty, pungent flavor and a neutral nature. It enters the Liver, Lung, and Stomach meridians. It has the effects of calming wind and relieving spasms, dispelling wind and relieving pain, and resolving phlegm and dispers

[0039] Magnolia officinalis (Magnolia officinalis), the dried bark of Magnolia officinalis, is bitter and pungent in flavor, warm in nature, and enters the spleen, stomach, lung, and large intestine meridians. It has the effects of drying dampness, eliminating phlegm, and relieving qi and fullness.

[0040] Pueraria root, also known as the dried root of Pueraria lobata or Pueraria lobata, is a member of the Leguminosae family. It has a sweet and pungent flavor and a cooling nature, entering the spleen, stomach, and lung meridians. It has the effects of relieving muscle tension and reducing fever, promoting fluid production and quenching thirst, clearing rashes, promoting yang and relieving diarrhea, promoting blood circulation and activating collaterals, and detoxifying alcohol. When combined with other herbs such as Chuanxiong, it can directly dilate blood vessels and reduce peripheral resistance.

[0041] The dried bark of Eucommia ulmoides (Eucommia ulmoides), Eucommia family. It is sweet, warm in nature, and enters the liver and kidney meridians. It nourishes the liver and kidneys, strengthens the bones and tendons, and stabilizes pregnancy.

[0042] Dipsacus root, ...

[0043] Smilax glabra (Smilax glabra) is the dried rhizome of Smilax china, a member of the Liliaceae family. It has a sweet, light flavor and a neutral nature. It enters the Liver and Stomach meridians. It clears heat and toxins, reduces swelling and resolves stagnation, removes dampness, and promotes joint function.

[0044] Honeysuckle vine, Caprifoliaceae; the dried stems and branches of honeysuckle are sweet in taste, neutral in nature, and enter the lung and stomach meridians. They have the effects of clearing away heat and detoxifying, dispersing wind and dredging collaterals. They are used for fever caused by febrile diseases, dysentery caused by heat toxins, carbuncles, sores, rheumatism, and red, swollen, hot and painful joints.

[0045] Chuanxiong (Ligusticum chuanxiong), a member of the Apiaceae family, is the dried rhizome of the plant. It is pungent and warm in nature, entering the liver, gallbladder, and pericardium meridians. It promotes blood circulation and qi, dispels wind, and relieves pain. It ascends to the head and descends to the blood vessels, making it a commonly used herb for treating symptoms of blood stasis, qi stagnation, and cold stagnation.

[0046] The dried root of Angelica sinensis (Apiaceae) is sweet, spicy, and warm in nature. It nourishes and invigorates blood circulation, regulates menstruation and relieves pain, and moistens the intestines and promotes bowel movements.

[0047] Ephedra (Ephedra sinica), Ephedraceae; the dried herbaceous stems have a faint aroma, a pungent and slightly bitter taste, and are warm in nature. They enter the lung and bladder meridians. They have the effects of diaphoresis, dispelling cold, promoting lung function, relieving asthma, and promoting diuresis and reducing swelling.

[0048] Cinnamon twigs, belonging to the Lauraceae family, are the dried young branches of cinnamon bark. They are pungent and sweet in flavor and warm in nature. They enter the heart, lung, and bladder meridians. They have the effects of inducing sweating and relieving muscle tension, warming and unblocking the meridians, promoting yang and transforming qi, and calming and descending qi. Modern pharmacological research has found that ephedra and cinnamon bark have anticoagulant, immunosuppressive, anti-inflammatory, and antioxidant effects. In this invention, cinnamon twigs are used instead of cinnamon bark for oral administration, and the therapeutic effects are similar when applied externally.

[0049] The Chinese medicine composition of the present invention is mainly composed of white medicine, which enters the lungs. The lungs govern the skin and fur, and the whole formula is clear and bright after being boiled. Blood stasis in the collaterals is one of the key pathogenesis of itching and pain in skin lesions and scars. The collaterals are used to clear the meridians, and the treatment is suitable for opening the pores and promoting the circulation of qi, removing turbidity and unblocking the collaterals. Qi deficiency and blood stasis, endogenous dampness and turbidity, should be treated by invigorating qi and activating blood circulation, reducing turbidity and expelling toxins. Long-term illness often causes blood stasis in the collaterals, resulting in the deficiency of collaterals and stagnation of the Xuanfu. The Xuanfu is the hub and gateway of the lung collaterals, and the lung collaterals are the nourishing pathway of the Xuanfu. The two fill the skin surface, connect the internal organs, and are dependent on each other. Wind evil, fire depression, dampness and turbidity, blood stasis, and toxin accumulation cause scars to be in a state of micro-inflammation for a long time, and the treatment is suitable for clearing wind and unblocking the collaterals, releasing fire depression, and removing stasis and promoting new blood. The Chinese medicine composition of the present invention uses Astragalus and Vaccariae as the main medicines, and Astragalus is reused to replenish qi, and its amount is large; Vaccariae is used to stop bleeding from wounds, promote blood circulation and dredge menstruation; Morus alba bark is used to promote diuresis and reduce swelling; Magnolia officinalis is used to dry dampness and eliminate phlegm; Ephedra opens the pores, and Cinnamon twig relieves cold and stagnation, etc., and when all the medicines are used together, the meridians of the skin lesions and scars caused by carbuncle and ulcer are restored, and the circulation of Qi and blood in the nutrient and defensive systems is unobstructed, and symptoms such as itching and pain are gradually alleviated or subsided. The Chinese medicine composition of the present invention is scientifically compatible, and the combination of all the medicines can achieve the effects of dispelling wind and relieving itching, clearing pus and detoxifying, reducing color and eliminating scars, and is used to treat skin ulcers, swellings and furuncles, and can also treat infected deep wounds. The use in wound treatment can reduce the demand for antibiotics.

[0050] The invention provides an oily agent for treating skin lesions and scars caused by carbuncle ulcers. The oily agent comprises the traditional Chinese medicine composition and an organic oil solvent.

[0051] In the present invention, the organic oil solvent is a plant-derived oil or a mineral oil. In specific embodiments of the present invention, the plant-derived oil includes, but is not limited to, castor oil, linseed oil, and sesame oil; the mineral oil includes, but is not limited to, paraffin oil. The addition of an organic oil solvent to the traditional Chinese medicine composition for decoction can serve as a drug carrier while also softening and protecting the skin.

[0052] In the present invention, the wax includes beeswax and cerasus chinensis. Beeswax is sweet, warm, and non-toxic. It has the effects of dispelling pus and blood from diarrhea, detoxifying sores, promoting tissue regeneration, and relieving pain. It is chemically stable, not easily rancid, and has antioxidant and antiseptic properties, making it commonly used as an excipient. cerasus chinensis is a secondary metabolite secreted by male larvae of the genus Ceroplastes, a member of the superfamily Coccoidea of ​​the order Hemiptera, on the branches of host plants. Its main component is wax esters with a carbon number ranging from 48 to 64, accounting for 93% to 95%. It is an insect medicine with a sweet, warm, and non-toxic nature. It has the functions of promoting tissue regeneration, stopping bleeding, relieving pain, and replenishing deficiency, strengthening tendons, and setting bones. It is an important surgical medicine.

[0053] The present invention provides a method for preparing the aforementioned oil preparation, comprising soaking the raw materials of the traditional Chinese medicine composition in an organic oil solvent for 15 to 50 days to obtain a mixture, boiling the mixture over high heat, and continuing to simmer over high heat for 3 to 5 hours until the oil drops into beads, filtering out the medicinal residue, and obtaining the oil preparation. The soaking temperature of the present invention is preferably room temperature. In the present invention, the soaking time is more preferably 20 to 40 days. More preferably, simmering over high heat for 4 hours is used. The term "high heat" used in the present invention is a term in Traditional Chinese Medicine, and conventional procedures in the art may be employed.

[0054] In the present invention, the mass ratio of the raw materials of the traditional Chinese medicine composition to the organic oil solvent is preferably 0.5 to 1:1, more preferably 1:1. The present invention increases the proportion of the traditional Chinese medicine composition in the oil solution, leaves no pigmentation during wound healing, and significantly reduces scar reaction.

[0055] The present invention also provides an ointment for treating skin lesions and scars caused by carbuncle ulcers, and the ointment comprises the traditional Chinese medicine composition.

[0056] The present invention provides a method for preparing the ointment, comprising soaking the raw materials of the traditional Chinese medicine composition in an organic oil solvent for 15 to 50 days to obtain a mixture, boiling the mixture over high heat, and continuing to simmer over high heat for 3 to 5 hours until the oil drops into beads, filtering out the medicinal residue to obtain an oil solution, and heating the oil solution again to boiling, pouring it into beeswax and insect wax, and thoroughly stirring to obtain the ointment. In the present invention, the soaking period is more preferably 20 to 45 days, and even more preferably 40 days. More preferably, the simmering period is 4 hours over high heat.

[0057] In the present invention, the mass ratio of the raw materials of the traditional Chinese medicine composition to the organic oil solvent is preferably 0.5 to 1:1, more preferably 1:1.

[0058] In the present invention, the oil, beeswax and white wax are preferably configured in a weight ratio of 5-15:0.5-1:0.5-1, and more preferably, the oil, beeswax and white wax are preferably configured in a weight ratio of 10:0.65:0.65.

[0059] The present invention also provides a use of the traditional Chinese medicine composition, the oil, the oil obtained by the preparation method, the ointment, or the ointment obtained by the preparation method in preparing a medicine for treating skin lesions and scars caused by carbuncles and ulcers.

[0060] The present invention also provides a use of the aforementioned traditional Chinese medicine composition, the aforementioned oil, or the aforementioned ointment obtained by the aforementioned preparation method, or the aforementioned ointment, or the aforementioned ointment obtained by the aforementioned preparation method, in preparing a medicament for treating psoriasis. The aforementioned traditional Chinese medicine composition has the therapeutic effects of moisturizing, relieving itching, and alleviating erythema of psoriasis lesions after use.

[0061] The present invention has no particular limitation on the source of the Chinese medicine, and conventional commercially available Chinese medicines well known to those skilled in the art may be used.

[0062] The technical solutions provided by the present invention are described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0063] Example 1

[0064] A traditional Chinese medicine composition for treating skin lesions and scars comprises the following raw materials in parts by weight: 30g of fenugreek, 30g of astragalus, 5g of bletilla striata, 5g of mulberry root bark, 5g of angelica dahurica, 5g of white ampelopsis, 5g of white dandelion bark, 5g of white mulberry bark, 5g of white mulberry, 5g of processed white aconite root, 5g of bombyx batryticatus, 5g of magnolia bark, 5g of kudzu root, 5g of eucommia bark, 5g of dipsaccharum officinale, 5g of rhizoma smilacis Glabrae, 5g of honeysuckle vine, 5g of ligusticum chuanxiong, 5g of angelica sinensis, 5g of ephedra, and 5g of cassia twig.

[0065] Example 2

[0066] A traditional Chinese medicine composition for treating skin lesions and scars comprises the following raw materials in parts by weight: 20g of fenugreek, 20g of astragalus, 3g of bletilla striata, 3g of mulberry root bark, 3g of angelica dahurica, 3g of white ampelopsis, 3g of white dandelion bark, 3g of white mulberry bark, 3g of white mulberry, 3g of processed white aconite root, 3g of bombyx batryticatus, 3g of magnolia bark, 3g of kudzu root, 3g of eucommia bark, 3g of dipsaccharum officinale, 3g of wild smilax, 3g of honeysuckle vine, 3g of ligusticum chuanxiong, 3g of angelica sinensis, 3g of ephedra, and 3g of cassia twig.

[0067] Example 3

[0068] A traditional Chinese medicine composition for treating skin lesions and scars comprises the following raw materials in parts by weight: 60g of fenugreek, 60g of astragalus, 10g of bletilla striata, 10g of mulberry root bark, 10g of angelica dahurica, 10g of white ampelopsis, 10g of white dandelion bark, 10g of white mulberry bark, 10g of white mulberry bark, 10g of white mulberry, 10g of processed white aconite root, 10g of bombyx batryticatus, 10g of magnolia bark, 10g of kudzu root, 10g of eucommia bark, 10g of dipsaccharum officinale, 10g of smilax glabra, 10g of honeysuckle vine, 10g of ligusticum chuanxiong, 10g of angelica sinensis, 10g of ephedra, and 10g of cassia twig.

[0069] Example 4

[0070] A method for preparing an oily preparation for treating skin lesions and scars caused by carbuncles, comprising the following steps: weighing the Chinese medicine composition according to Example 1, preparing and soaking the mixture with 155 mL of sesame oil for 40 days, boiling the mixture over high heat, and continuing to simmer over high heat for 4 hours until the oil drops into beads, filtering out the medicinal residue, and obtaining an oily preparation. Figure 1 .

[0071] Example 5

[0072] The difference from Example 4 is that the Chinese medicine composition is weighed as in Example 2, and the other steps remain unchanged.

[0073] Example 6

[0074] The difference from Example 4 is that the Chinese medicine composition is weighed as in Example 3, and the other steps remain unchanged.

[0075] Example 7

[0076] The difference from Example 4 is that the mass ratio of the Chinese medicine composition to the sesame oil is 0.5:1, and the other steps remain unchanged.

[0077] Comparative Example 1

[0078] Take 200g of Radix Astragali, 100g of Herba Schizonepetae, 100g of Radix Saposhnikoviae, 100g of Radix Scutellariae, 100g of Radix Sophorae Flavescentis, 100g of Radix Paeoniae Rubra, 100g of Radix Angelicae Dahuricae, 100g of Rhizoma Acorus Tatarinowii, 100g of Radix Angelicae Pubescentis, 100g of Radix Notopterygii, 100g of Flos Lonicerae, 100g of Caulis Piperis Kadurae, 100g of Achyranthes Bidentatae, 100g of Polygonatum, 30g of Ramulus Mori, 20g of Scolopendra, 20g of Scorpio, 20g of Hirudo, 20g of Pheretima, and 6440ml of sesame oil. After mixing the above-mentioned raw materials with sesame oil, soak them for 30 days, then use high heat to boil to boiling, then use slow fire to keep 120°C and boil for 12h, and obtain carbuncle oil after filtering out the medicinal residues, as specifically shown in the patent CN111603537A.

[0079] Example 8

[0080] A preparation method for treating skin lesions and scars comprises the following steps: heating the oil prepared in Example 4 to boiling again, pouring the mixture into prepared beeswax and paraffin wax in a ratio of 10:0.65:0.65, stirring thoroughly to form a paste, and bottling the paste for later use.

[0081] Example 9

[0082] The difference from Example 8 is that the oil: beeswax: insect wax are prepared in a ratio of 5:0.5:0.5, and the other steps remain unchanged.

[0083] Example 10

[0084] The difference from Example 8 is that the oil: beeswax: insect wax are prepared in a ratio of 15:1:1, and the other steps remain unchanged.

[0085] Application Example 1

[0086] 20 patients who were diagnosed with postoperative fat liquefaction of incision after laparotomy or complicated infection were selected and the oil prepared in Example 4 of the present invention and the improved carbuncle oil prepared in Comparative Example 1 were applied to the skin. Figure 2 ), and the changes in the scores of the affected area are shown in Table 1.

[0087] Estimation and scoring of exudate volume:

[0088] Estimate the amount of exudate based on the permeability of the dressing, including increased, unchanged, decreased, or absent secretions.

[0089] Dry without moisture seepage is scored as 0 points;

[0090] Exudate <5 mL in 24 hours was considered small amount and scored 1 point;

[0091] 5-10 mL is considered a medium dose and is scored as 2 points;

[0092] >10mL is considered a large amount and is scored 3 points.

[0093] The pain score was scored using the VAS pain scoring system:

[0094] 0 points: no pain;

[0095] 3 points or less: mild pain, which the patient can tolerate;

[0096] 4-6 points: The patient has pain that affects sleep but is still tolerable;

[0097] 7-10 points: The patient has severe pain and the pain is unbearable.

[0098] Scar scoring was performed using the Vancouver Scar Scale, and the specific scoring criteria are as follows:

[0099] Color (M): 0 points: the color of the scar is similar to the color of the normal skin on the body; 1 point: lighter color; 2 points: mixed color; 3 points: darker color.

[0100] Thickness (H): 0 points: normal; 1: <1mm; 2 points: 1-2mm; 3 points: 2-4mm; 4 points: >4mm.

[0101] Vascular distribution (V): 0 points: The skin color of the scar is similar to that of normal parts of the body; 1 point: The skin color is pink; 2 points: The skin color is reddish; 3 points: The skin color is purple.

[0102] Softness (P): 0: normal; 1: soft (skin can be deformed with minimal resistance); 2: compliant (can be deformed under pressure); 3: hard (cannot be deformed, moves in a blocky manner, and resists pressure); 4: tortuosity (tissue is like a rope and will retract when the scar stretches); 5: contracture (permanent shortening of the scar causes disability and distortion).

[0103] The total score of the scale is 15 points, and higher scores indicate more severe scars.

[0104] Table 1 Local assessment of fat liquefaction and concurrent infection in the incision after laparotomy

[0105]

[0106]

[0107] The comprehensive effects of the oil prepared in Example 4 of the present invention and the oil prepared in Comparative Example 1 were compared, and the results are shown in Table 2:

[0108] Table 2 Comparison of the comprehensive effects of the oil of the present invention and the improved carbuncle oil

[0109] Example 4 Comparative Example 1 Texture of the finished product clear Thick Reduce edema Strong powerful pain relief Strong powerful Healing time Faster quick scarring Not obvious More obvious Pigmentation Rare Occasionally Antipruritic effect Strong Weaker

[0110] It can be seen from Table 1 and Table 2 that, compared with the improved carbuncle oil, the Chinese medicine composition oil of the present invention leaves no pigmentation when used for scar restoration, significantly reduces scar reaction, and has a better antipruritic effect.

[0111] Typical Cases

[0112] Case 1: A 4-year-old girl was diagnosed with excavating folliculitis on her head for 1 month. After surgical debridement, the wound on her head did not improve but deepened. For conservative treatment, the oil of Example 4 of the present invention was applied over a large area. The dressing was changed once a day for 45 consecutive days. The wound healed completely and the scar was not obvious. Figure 3 .

[0113] Case 2: A 48-year-old female patient with type 2 diabetes underwent laparotomy. The wound had fat liquefaction, which was manifested as a small mouth and a large cavity. The patient was treated with the oil preparation of Example 4 of the present invention for internal filling and external application. The dressing was changed once a day for 15 consecutive days. The wound healed completely and the scar was not obvious. Figure 4 .

[0114] Case 3: A 62-year-old female patient underwent laparotomy and intraperitoneal hyperthermic perfusion three times. The wound was red, swollen, painful, and had a lot of exudate. The oily preparation of Example 4 of the present invention was applied over a large area, with dressing changed once a day for 7 consecutive days. The wound healed completely and the scar was not obvious. Figure 5 .

[0115] Case 4: A male patient was injured by jellyfish 2 months ago. The wound did not improve after treatment but became more and more serious. After applying the oil of Example 4 of the present invention on a large area, changing the dressing once a day for 7 consecutive days, the wound healed completely, and the scar and pigmentation were not obvious. Figure 6 .

[0116] Case 5: A 2-year-old male patient had a large area of ​​finger defect after trauma. Surgeons from several hospitals recommended skin grafting surgery, but his parents refused the surgery. In order to seek conservative treatment, the oil of Example 4 of the present invention was applied to a large area of ​​the finger. The dressing was changed once a day for 28 consecutive days. The wound healed completely and the scar was not obvious. Figure 7 .

[0117] Case 6: A 58-year-old female patient had a thoracotomy valve replacement surgery. She suffered from repeated itching and infection of the scar. Multiple surgeries failed to solve the scar problem. For conservative treatment, she applied the oil of Example 4 of the present invention to a large area of ​​the skin. The dressing was changed once a day. After 7 consecutive days of application, the itching and pain symptoms were relieved, and the color and softness of the scar were significantly improved. Figure 8 .

[0118] Case 7: A 31-year-old female patient complained that after she had been treated in the burn department of a hospital for trauma, the scar on the wound surface was growing larger. She had undergone one surgery to remove the scar, but the effect was not ideal. The scar continued to grow and it was accompanied by itching. For conservative treatment, the oil of Example 4 of the present invention was applied to a large area, with the dressing changed once a day. After two weeks of continuous application, the symptoms of itching, pain, color and softness were significantly relieved. Figure 9 .

[0119] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating skin lesions and scars, characterized in that: The traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 20-60 parts of fenugreek, 20-60 parts of astragalus, 3-10 parts of bletilla striata, 3-10 parts of mulberry root bark, 3-10 parts of angelica dahurica, 3-10 parts of white ampelopsis, 3-10 parts of white dandelion, 3-10 parts of white mulberry bark, 3-10 parts of white mulberry, 3-10 parts of white mulberry, 3-10 parts of processed white aconite, 3-10 parts of bombyx batryticatus, 3-10 parts of magnolia bark, 3-10 parts of kudzu root, 3-10 parts of eucommia, 3-10 parts of dipsaccharum officinale, 3-10 parts of wild smilax, 3-10 parts of honeysuckle vine, 3-10 parts of ligusticum chuanxiong, 3-10 parts of angelica sinensis, 3-10 parts of ephedra, and 3-10 parts of cassia twig.

2. An oily preparation for treating skin lesions and scars, characterized in that: The oil preparation is prepared from the traditional Chinese medicine composition according to claim 1 and an organic oil solvent.

3. The oil according to claim 2, characterized in that The organic oil solvent is plant-extracted oil or mineral oil.

4. The method for preparing the oil according to claim 2 or 3, characterized in that: The raw materials of the traditional Chinese medicine composition are soaked in an organic oil solvent for 15 to 50 days to obtain a mixture, the mixture is boiled with high heat, and the mixture is simmered with high heat for 3 to 5 hours until the oil drops into beads, and the residue is filtered to obtain an oil preparation.

5. The preparation method according to claim 4, characterized in that The mass volume ratio of the raw materials of the traditional Chinese medicine composition to the organic oil solvent is 0.5-1g:1mL.

6. An ointment for treating skin lesions and scars, characterized in that: The active ingredient of the ointment is the traditional Chinese medicine composition according to claim 1.

7. The method for preparing the ointment according to claim 6, characterized in that: The raw materials of the traditional Chinese medicine composition are soaked in an organic oil solvent for 15 to 50 days to obtain a mixture, the mixture is boiled using high heat, and the mixture is continued to be boiled using high heat for 3 to 5 hours until the oil drops into beads, and the medicinal residue is filtered to obtain an oil solution; the oil solution is heated to boiling again, poured into beeswax and insect white wax, and fully stirred to obtain an ointment.

8. The preparation method according to claim 7, characterized in that The mass volume ratio of the raw materials of the traditional Chinese medicine composition to the organic oil solvent is 0.5-1g:1mL.

9. The preparation method according to claim 7, characterized in that The oil, beeswax and insect wax are configured in a weight ratio of 5-15:0.5-1:0.5-1.

10. Use of the traditional Chinese medicine composition according to claim 1, the oil according to claim 2 or 3, the oil obtained by the preparation method according to claim 4 or 5, the ointment according to claim 6, or the ointment obtained by the preparation method according to any one of claims 7 to 9 in the preparation of a medicine for treating skin lesions and scars caused by carbuncles and ulcers.

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