An asymmetric enhanced acylhydrazone Schiff base fluorescent probe, its preparation method and application

Abstract

This invention relates to Zn 2+ This invention relates to the field of concentration detection technology, specifically to an asymmetric enhanced acylhydrazone Schiff base fluorescent probe, its preparation method, and its applications. The fluorescent probe should introduce as many electron-rich atoms as possible, such as O and N, that are favorable to the -C=N- structure space of the Schiff base, thereby creating a more favorable electron-rich chemical environment for coordination between the Schiff base and metal ions. The acylhydrazone Schiff base structure contains three conjugated groups: carbonyl, subamino, and imino. The subamino group contains a lone pair of electrons, which can form p-π conjugations with -C=N- and carbonyl groups, respectively. This conjugated structure makes the Schiff base more stable and less prone to reversible hydrolysis like other Schiff bases. The introduction of the acylhydrazone group enhances the fluorescence of the probe and improves its targeting of Zn. 2+ It exhibits good selectivity, excellent linearity, high sensitivity, low detection limit, and low cost, making it widely applicable to Zn. 2+ The detection of Zn in existing technologies solves the problem. 2+ Fluorescent probe synthesis is complex and costly, and has limitations for Zn. 2+ The problem of low recognition rate.

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