A Chinese medicine composition for strengthening the body and clearing away heat for treating Guillain-Barré syndrome and a Chinese medicine hot compress pack

Abstract

The invention discloses a Chinese medicine composition for strengthening the body and clearing away heat and a Chinese medicine hot compress bag. The Chinese medicine composition comprises codonopsis pilosula, astragalus, tuckahoe, liquorice, ginkgo, eclipta, scrophularia, salvia miltiorrhiza, red peony root, persimmon leaf, mulberry, complanatus, lily of the valley, purslane, aloe, malt, oroxylum, herba discolor, radix sojae, radix scutellariae and phellodendron chinense. The Chinese medicine bag of the Chinese medicine hot compress bag is prepared from the Chinese medicine composition to obtain powder, which is packaged to obtain the powder. The heating layer comprises a self-heating bag and a fumigation bag. The invention improves the basic prescription for strengthening the body and clearing away heat for treating GBS, and improves the components and proportions of the Chinese medicine composition on the basis of continuing the idea of ​​strengthening the body for treatment. A total of 20 Chinese medicinal materials complement each other. Clinical experiments have proved that the Chinese medicine composition is suitable for a wider range of patients, and there is no need to adjust the dosage of each prescription for each person. The components and proportions can be unified, which is convenient for application. The Chinese medicine hot compress bag of the invention allows more effective ingredients to volatilize, has a long duration, is easy to use, and helps to improve the efficacy.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine, relates to a traditional Chinese medicine composition and a traditional Chinese medicine hot compress pack, and in particular to a traditional Chinese medicine composition for strengthening the body and clearing away heat and a traditional Chinese medicine hot compress pack. Background Art

[0002] Guillain-Barre syndrome (GBS), also known as Guillain-Barré syndrome, is an autoimmune disease characterized by demyelination of peripheral nerves and nerve roots and inflammatory reactions of lymphocytes and macrophages around small blood vessels. In the early stage of GBS, inflammatory cells can cause damage or death of Schwann cells, segmental demyelination, and even secondary axonal degeneration. Therefore, GBS patients often suffer from limb function degeneration and electrophysiological abnormalities showing conduction disorders of limb sensation and movement. At present, the pathogenesis of GBS is not completely clear, and therefore, its treatment is difficult. When necessary, some patients need to be admitted to the ICU for mechanical ventilation. For non-critical patients, modern medicine mainly uses symptomatic treatment (such as immunomodulation and plasma exchange, etc.) and supportive strategies (such as neurotrophy, etc.) to treat. But precisely because of this, the effect of modern medicine in treating GBS is not ideal. Especially after the acute phase, the peripheral nerve function of most patients cannot be quickly restored, and they often have fatigue and subsequent inflammatory reactions.

[0003] The clinical manifestations of GBS are similar to "paralysis" in traditional Chinese medicine, with the main syndrome differentiation characteristics of intense heat evil and weak vital energy, and the main limb symptoms of weakness, relaxation of meridians, and even muscle atrophy or paralysis. Therefore, symptomatic treatment can be carried out with the idea of ​​strengthening the vital energy and clearing away heat, with Qi-tonifying drugs (such as Astragalus, Atractylodes macrocephala, Licorice, etc.) combined with drugs for removing dampness and heat (such as Atractylodes macrocephala, Phellodendron chinense, Coix seed, etc.), so that patients can take compound Chinese herbal decoctions that strengthen the vital energy, clear dampness and heat, and cool the blood and activate blood circulation. The Chinese document "Observation on the Efficacy of Fuzheng Qingre Compound Prescription Combined with Conventional Therapy in the Treatment of Acute Guillain-Barré Syndrome" (Chinese Journal of Integrated Traditional and Western Medicine, Vol. 39, No. 12, December 2019, 1440-1441) disclosed by the inventor confirms that this treatment idea can achieve certain efficacy. The basic prescription used for Fuzheng Qingre is, by mass, 60 parts of Astragalus, 12 parts of Raw Licorice, 10 parts of Atractylodes, 10 parts of Phellodendron, 10 parts of Coix Seed, 10 parts of Salvia Miltiorrhiza, 10 parts of Red Peony Root, and 12 parts of Poria. According to preliminary clinical data, the above basic prescription can improve the recovery of some suitable people, but the overall effect still has room for improvement.

[0004] Therefore, there is a need to study traditional Chinese medicine compositions that have better repeatability, are applicable to a wider population, and have better efficacy in the acute and recovery stages of GBS. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for strengthening the body and clearing away heat with a wider user population and better efficacy for the treatment of acute and recovery stages of GBS, and to provide a Chinese medicine hot compress bag for the convenience of use and treatment.

[0006] The technical solution adopted by the present invention provides a Chinese medicine composition for strengthening the body and clearing away heat. The key lies in that, measured by weight, the Chinese medicine composition includes 10-14 parts of Codonopsis pilosula, 25-35 parts of Astragalus membranaceus, 10-14 parts of Poria cocos, 10-14 parts of Licorice root, 10-14 parts of Ginkgo biloba, 4-8 parts of Eclipta prostrata, 10-14 parts of Scrophularia ningpoensis, 8-12 parts of Salvia miltiorrhiza, 10-14 parts of Red Peony Root, 4-8 parts of Diospyros kaki leaves, 8-12 parts of Mulberry, 8-12 parts of Astragalus membranaceus, 4-8 parts of Achyranthes bidentata, 8-12 parts of Portulaca oleracea, 8-12 parts of Aloe vera, 4-8 parts of malt, 4-8 parts of Oroxylum indica, 4-8 parts of Herba Discoloris, 10-14 parts of Fructus Sophorae Flavescentis, and 7-11 parts of Phellodendron amurense.

[0007] Preferably, in parts by mass, the above-mentioned traditional Chinese medicine composition includes 12 parts of Codonopsis pilosula, 30 parts of Astragalus membranaceus, 12 parts of Poria cocos, 12 parts of Licorice, 12 parts of Ginkgo, 6 parts of Eclipta prostrata, 12 parts of Scrophularia ningpoensis, 10 parts of Salvia miltiorrhiza, 12 parts of Red Peony Root, 6 parts of Diospyros kaki leaves, 10 parts of Mulberry, 10 parts of Astragalus membranaceus, 6 parts of Achyranthes bidentata, 10 parts of Portulaca oleracea, 10 parts of Aloe, 6 parts of malt, 6 parts of Oroxylum indica, 6 parts of Herba Potentillae, 12 parts of Fructus Sojae Indici, and 9 parts of Phellodendron amurense.

[0008] A Chinese medicine hot compress bag comprises a Chinese medicine bag layer and a heating layer. The key point is that the Chinese medicine bag layer is obtained by preparing the Chinese medicine composition to obtain powder, which is then packaged; the heating layer comprises a self-heating bag and a fumigation bag; and the components of the self-heating bag include 50-60 parts of iron powder, 5-10 parts of activated carbon, 8-12 parts of sodium chloride, 10-15 parts of vermiculite, 30-40 parts of water and 1-4 parts of water-absorbing resin in parts by mass.

[0009] Furthermore, the components of the fumigation bag include calcium bicarbonate and vermiculite, and in terms of mass fractions, the calcium bicarbonate is 20 to 40 parts and the vermiculite is 40 to 60 parts.

[0010] Specifically, the specific steps of preparing the above-mentioned Chinese medicine composition are:

[0011] The above-mentioned Chinese medicine composition is crushed, and soaked with an ethanol solution to obtain an soaking liquid, and the soaking liquid is crushed and filtered by high-pressure homogenization to obtain a filtrate and a filter residue respectively;

[0012] The filtrate is subjected to rotary evaporation to obtain crystals, which are dried to obtain a Chinese medicine extract;

[0013] Drying the filter residue;

[0014] The Chinese herbal medicine extract and the filter residue are mixed and packaged or packaged separately.

[0015] Preferably, the conditions for the high-pressure homogenization and crushing are homogenization at 850 bar to 1200 bar for 20 to 30 times; and the mass concentration of the ethanol solution is 75% to 85%.

[0016] Optimally, the mass ratio of the above-mentioned Chinese herbal medicine extract to the above-mentioned filter residue is 1 to 3:1.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] The present invention improves the basic prescription of strengthening the body and clearing away heat for treating GBS, and improves the components and proportions of the Chinese medicine composition on the basis of continuing the idea of ​​strengthening the body and clearing away heat. A total of 20 Chinese medicinal materials complement each other. Among them, persimmon leaves are recorded in "Bencao Zaixin" as "bitter, cold, non-toxic" and "specially enter the lung meridian". They are rarely used in the general strengthening and clearing away heat components, but persimmon leaves have the effects of improving the body's immune function, lowering blood lipids, preventing cerebral arteriosclerosis, coronary heart disease, etc., which are helpful for the later recovery of GBS patients. Other components in this prescription can alleviate the coldness of persimmon leaves. For example, Liu Jinu has the effects of healing wounds and stopping bleeding, breaking blood and dredge meridians, and is generally used for acute icteric hepatitis, toothache, chronic tracheitis, stomatitis, pharyngitis, tonsillitis, nephritis, malaria and other diseases. This prescription uses its effects of digesting food and eliminating accumulation, waking up the spleen and appetizing, which helps to promote the digestive ability of bedridden patients and improve physical function. This prescription enriches the basic idea of ​​strengthening the body and clearing away heat. Clinical experiments have shown that it is suitable for a wider range of patients. Moreover, there is no need to adjust the dosage for each individual prescription. The components and proportions can be unified, making it easy to use.

[0019] At the same time, the Chinese medicine hot compress pack of the present invention is supplemented by the self-heating pack and the fumigation pack, so that more effective ingredients can be volatilized, the duration is long, the use is convenient, and it is helpful to improve the therapeutic effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a radar chart of the volatilization of the active ingredients in the embodiments of the present invention and the comparative examples. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] Embodiment 1 to Embodiment 4 are embodiments of a Chinese medicine composition for strengthening the body and clearing away heat

[0023] Embodiment 1

[0024] A Chinese medicine composition for strengthening the body and clearing away heat, which comprises, by weight, 10 parts of Codonopsis pilosula, 25 parts of Astragalus, 12 parts of Poria, 14 parts of Licorice, 10 parts of Ginkgo, 4 parts of Ecliptae, 12 parts of Scrophularia, 8 parts of Salvia miltiorrhiza, 12 parts of Paeonia lactiflora, 4 parts of Persimmon Leaf, 8 parts of Morus, 12 parts of Astragalus, 6 parts of Achyranthes bidentata, 12 parts of Portulaca oleracea, 10 parts of Aloe, 8 parts of Malt, 6 parts of Oroxylum indica, 6 parts of Herba Polygoni Multiflori, 12 parts of Fructus Sojae, and 7 parts of Phellodendron. Soak the above Chinese medicine raw materials in cold water for 30 minutes, and simmer for 30 minutes from the beginning of boiling; 15 minutes for the second decocting, and take about 300 mL of juice in total. Take it twice on an empty stomach, morning and evening.

[0025] In this embodiment, g can also be used as the unit of measurement, no decoction required, 14 packs, one dose per day, one dose is taken twice a day on an empty stomach, morning and evening.

[0026] Embodiment 2

[0027] A Chinese medicine composition for strengthening the body and clearing away heat, which comprises, by weight, 14 parts of Codonopsis pilosula, 35 parts of Astragalus, 14 parts of Poria, 10 parts of Licorice, 14 parts of Ginkgo, 6 parts of Eclipta prostrata, 10 parts of Scrophularia ningpoensis, 10 parts of Salvia miltiorrhiza, 10 parts of Paeonia lactiflora, 8 parts of Persimmon leaf, 12 parts of Morus alba, 10 parts of Astragalus complanatus, 8 parts of Achyranthes bidentata, 8 parts of Portulaca oleracea, 8 parts of Aloe, 4 parts of Malt, 4 parts of Oroxylum indica, 8 parts of Herba Polygoni discolor, 10 parts of Fructus Sojae chinensis, and 9 parts of Phellodendron amurense. Soak the above Chinese medicine raw materials in cold water for 30 minutes, and simmer for 30 minutes from the beginning of boiling; 15 minutes for the second decocting, and a total of about 300 mL of juice is taken. Take it twice on an empty stomach, morning and evening.

[0028] In this embodiment, g can also be used as the unit of measurement, no decoction required, 14 packs, one dose per day, one dose is taken twice a day on an empty stomach, morning and evening.

[0029] Embodiment 3

[0030] A Chinese medicine composition for strengthening the body and clearing away heat, in terms of mass, comprises 12 parts of Codonopsis pilosula, 30 parts of Astragalus, 12 parts of Poria, 12 parts of Licorice, 12 parts of Ginkgo, 6 parts of Ecliptae, 12 parts of Scrophularia, 10 parts of Salvia miltiorrhiza, 12 parts of Paeonia lactiflora, 6 parts of Persimmon Leaf, 10 parts of Morus, 10 parts of Astragalus, 6 parts of Achyranthes bidentata, 10 parts of Portulaca oleracea, 10 parts of Aloe, 6 parts of Malt, 6 parts of Oroxylum indica, 6 parts of Herba Polygoni Multiflori, 12 parts of Fructus Sojae, and 9 parts of Phellodendron. Soak the above Chinese medicine raw materials in cold water for 30 minutes, and simmer for 30 minutes from the beginning of boiling; 15 minutes for the second decocting, and a total of about 300 mL of juice is taken. Take it twice on an empty stomach, morning and evening.

[0031] In this embodiment, g can also be used as the unit of measurement, no decoction required, 14 packs, one dose per day, one dose is taken twice a day on an empty stomach, morning and evening.

[0032] Embodiment 4

[0033] A Chinese medicine composition for strengthening the body and clearing away heat, which comprises, by weight, 10 parts of Codonopsis pilosula, 30 parts of Astragalus, 10 parts of Poria, 12 parts of Licorice, 12 parts of Ginkgo, 8 parts of Eclipta prostrata, 14 parts of Scrophularia ningpoensis, 12 parts of Salvia miltiorrhiza, 14 parts of Paeonia lactiflora, 4 parts of Persimmon leaf, 8 parts of Morus alba, 8 parts of Astragalus complanatus, 4 parts of Achyranthes bidentata, 10 parts of Portulaca oleracea, 12 parts of Aloe, 6 parts of Malt, 8 parts of Oroxylum indica, 4 parts of Herba Polygoni Multiflori, 14 parts of Fructus Sojae chinensis, and 11 parts of Phellodendron amurense. Soak the above Chinese medicine raw materials in cold water for 30 minutes, and simmer for 30 minutes from the beginning of boiling; 15 minutes for the second decocting, and a total of about 300 mL of juice is taken. Take it twice on an empty stomach, morning and evening.

[0034] In this embodiment, g can also be used as the unit of measurement, no decoction required, 14 packs, one dose per day, one dose is taken twice a day on an empty stomach, morning and evening.

[0035] Embodiment 5 to Embodiment 7 are embodiments of a Chinese medicine hot compress pack

[0036] Embodiment 5

[0037] A Chinese medicine hot compress pack, comprising:

[0038] The components and proportions of the Chinese medicine coating are the same as those in Example 3, calculated by weight: the mixing weight ratio of the Chinese medicine extract and the filter residue is 2:1, including 40 parts of the Chinese medicine extract and 20 parts of the filter residue.

[0039] The components of the self-heating bag are calculated by mass: 55 parts of iron powder, 8 parts of activated carbon, 10 parts of sodium chloride, 10 parts of vermiculite, 40 parts of water and 1 part of water-absorbing resin.

[0040] The components of the fumigation bag are calculated by mass: 30 parts of calcium bicarbonate and 50 parts of vermiculite.

[0041] The preparation method of the Chinese medicine coating is as follows:

[0042] The Chinese medicine composition was crushed according to the ratio described in Example 3, and soaked in an ethanol solution with a mass concentration of 80% and a volume twice that of the Chinese medicine composition for 8 hours to obtain an immersion liquid, and the immersion liquid was crushed 25 times at a crushing pressure of 1000 bar, and filtered to obtain a filtrate and a filter residue, respectively;

[0043] The filtrate is subjected to rotary evaporation to obtain crystals, which are dried to obtain a Chinese medicine extract;

[0044] Dry the filter residue at 80°C;

[0045] The Chinese herbal medicine extract and the filter residue are mixed in a mass ratio of 2:1 and then packaged.

[0046] Embodiment 6

[0047] A Chinese medicine hot compress pack, comprising:

[0048] The components and proportions of the Chinese medicine coating are the same as those in Example 3, calculated by weight: the mixing weight ratio of the Chinese medicine extract and the filter residue is 1:1, including 30 parts of the Chinese medicine extract and 30 parts of the filter residue.

[0049] The components of the self-heating bag are calculated by mass: 50 parts of iron powder, 10 parts of activated carbon, 8 parts of sodium chloride, 12 parts of vermiculite, 30 parts of water and 2 parts of water-absorbing resin.

[0050] The components of the fumigation bag are calculated by mass: 40 parts of calcium bicarbonate and 40 parts of vermiculite.

[0051] The preparation method of the Chinese medicine coating is as follows:

[0052] The Chinese medicine composition was crushed according to the ratio recorded in Example 1, and soaked in an ethanol solution with a mass concentration of 75% and a volume twice that of the Chinese medicine composition for 10 hours to obtain an immersion liquid, and the immersion liquid was crushed 30 times at a crushing pressure of 1200 bar, and filtered to obtain a filtrate and a filter residue respectively;

[0053] The filtrate is subjected to rotary evaporation to obtain crystals, which are dried to obtain a Chinese medicine extract;

[0054] Dry the filter residue at 80°C;

[0055] The above-mentioned Chinese medicine extract and the filter residue are packaged separately in a mass ratio of 1:1.

[0056] Embodiment 7

[0057] A Chinese medicine hot compress pack, comprising:

[0058] The components and proportions of the Chinese medicine coating are the same as those in Example 3, calculated by weight: the mixing weight ratio of the Chinese medicine extract and the filter residue is 3:1, including 60 parts of the Chinese medicine extract and 20 parts of the filter residue.

[0059] The components of the self-heating bag are calculated by mass: 60 parts of iron powder, 5 parts of activated carbon, 12 parts of sodium chloride, 11 parts of vermiculite, 35 parts of water and 4 parts of water-absorbing resin.

[0060] The components of the fumigation bag are calculated by mass: 20 parts of calcium bicarbonate and 60 parts of vermiculite.

[0061] The preparation method of the Chinese medicine coating is as follows:

[0062] The Chinese medicine composition was crushed according to the ratio described in Example 2, and soaked in an ethanol solution with a mass concentration of 85% and a volume twice the volume of the Chinese medicine composition for 6 hours to obtain an immersion liquid, and the immersion liquid was crushed 20 times at a crushing pressure of 850 bar, and filtered to obtain a filtrate and a filter residue respectively;

[0063] The filtrate is subjected to rotary evaporation to obtain crystals, which are dried to obtain a Chinese medicine extract;

[0064] Dry the filter residue at 80°C;

[0065] The Chinese herbal medicine extract and the filter residue are mixed in a mass ratio of 3:1 and then packaged.

[0066] Comparative Example 1

[0067] A Chinese medicine hot compress bag, the implementation method is the same as that of Example 5, except that there is no fumigation bag.

[0068] Comparative Example 2

[0069] A Chinese medicine hot compress bag, the implementation method is the same as that of Example 5, except that the Chinese medicine bag does not require the preparation of a Chinese medicine coating layer, and the Chinese medicine composition is directly mixed according to proportion, crushed, and then packaged.

[0070] Analysis and testing

[0071] 1. Fever time

[0072] The hot compress packs of Examples 5 to 7 and the hot compress packs of Comparative Examples 1 and 2 were tested for the duration of time the surface temperature of the Chinese medicine hot compress packs was above 40°C. The results are shown in Table 1.

[0073] Table 1: Results of duration of fever

[0074]

[0075]

[0076] From the results in Table 1, it can be seen that the fumigation bag can also help to prolong the heating time.

[0077] 2. Volatility test

[0078] The electronic nose was used to conduct qualitative analysis on the hot compress packs of Examples 5 to 7 and Comparative Examples 1 and 2. The results are shown in Figure 1 .

[0079] Depend on Figure 1 The results show that, taking the 9 main active ingredients detected by the electronic nose as an example, the contents of Examples 5 to 7 are all higher than those of Comparative Example 1, indicating that the fumigation bag helps the volatilization of the active ingredients of the traditional Chinese medicine bag; the volatilization of the active ingredients in Comparative Example 2 is the worst, which shows that the traditional Chinese medicine bag preparation process of the present invention helps the active ingredients to volatilize better.

[0080] Clinical implementation methods and effects

[0081] Clinical implementation methods

[0082] 1. Diagnostic criteria and TCM syndrome differentiation criteria:

[0083] The diagnosis of GBS refers to the "Guidelines for the Diagnosis and Treatment of Guillain-Barré Syndrome in China", which includes the typical clinical features of GBS, combined with cerebrospinal fluid examination and neuroelectrophysiological testing to assist in diagnosis.

[0084] The TCM syndrome differentiation standards for damp-heat type refer to "Chinese Medicine Diagnosis" and "Chinese Medicine Internal Medicine".

[0085] 2. General Information

[0086] A total of 450 GBS patients were selected and randomly divided into treatment group 1, treatment group 2 and control group, with 150 patients in each group.

[0087] Treatment group 1: 103 males and 47 females, aged 12 to 68 years old, average (36.8±13.8) years old, disease course 1 to 14 days, average (7.2±2.1) days;

[0088] Treatment group 2: 106 males and 44 females, aged 11 to 64 years old, average (35.3±14.2) years old, disease course 1 to 14 days, average (7.6±2.3) days;

[0089] The control group included 108 males and 42 females, aged 10 to 68 years old (average: (37.2±15.1) years old), with a disease course of 1 to 14 days (average: (6.6±2.9) days).

[0090] There was no significant difference in general information among the three groups (P>0.05).

[0091] The above three groups of cases were subjected to TCM damp-heat syndrome differentiation, and the results are shown in Table 2.

[0092] Table 2: Results of TCM Syndrome Differentiation of Damp-Heat Type

[0093]

[0094] During the recovery period, 5 cases dropped out in the control group, and 2 cases dropped out in the treatment group 1 and the treatment group 2, respectively.

[0095] 3. Treatment methods

[0096] All three groups received conventional treatment:

[0097] (1) During the acute phase, patients should rest in bed and place their limbs in a functional position. Closely observe vital signs, lung and heart function, keep the airway open, turn over and pat the back regularly to expel respiratory secretions. Patients with dysphagia should be fed nasogastricly as soon as possible, and pay attention to water and electrolyte balance. Prevent the occurrence of pneumonia, atelectasis, corneal ulcers, deep vein thrombosis and bedsores. Symptomatic treatment should be given if changes in blood pressure, heart rhythm disorders, constipation and urinary retention are found.

[0098] (2) Intravenous drip of 5% glucose injection or 0.9% sodium chloride injection 250 mL plus vitamin B6 0.2 g once a day; intramuscular injection of vitamin B12 0.5 mg once a day; intravenous injection of immunoglobulin 0.4 g / kg for 5 consecutive days.

[0099] Treatment group 1 was treated with the Chinese medicinal composition for strengthening the body and clearing away heat of the present invention (the proportion of the Chinese medicinal composition was that of Example 3), and treatment group 2 was treated with the Chinese medicinal composition for strengthening the body and clearing away heat of the present invention (the proportion of the Chinese medicinal composition was that of Example 3) and a Chinese medicinal hot compress pack (Example 5). All three groups were treated for one month.

[0100] 4. Observation indicators and methods

[0101] (1) Daily living ability score:

[0102] The Barthel index of the general daily living ability ADL scale was used for scoring, with a score of 100 and a score below 60 indicating difficulty in self-care.

[0103] (2) Assessment of limb motor function:

[0104] The assessment of limb motor function refers to the Hughes standard, which includes 0 to 6 levels, where 0 is healthy; 1 is mild neurological symptoms and signs, but can run; 2 is able to walk 5 meters independently; 3 is able to walk 5 meters with support; 4 is confined to bed or in a wheelchair; 5 requires assisted breathing; and 6 is death.

[0105] (3) Assessment of sensory dysfunction:

[0106] The sensory function was assessed according to the Hughes standard, which includes grades 0 to 4, with grade 0 being normal; grade 1 being subjective sensory abnormalities but no objective signs; grade 2 being decreased or absent sensations beyond the wrist and ankle; grade 3 being decreased or absent sensations beyond the elbow and knee; and grade 4 being decreased or absent sensations beyond the shoulder and arm.

[0107] (4) Overall efficacy evaluation: Refer to the "Clinical Disease Diagnosis and Efficacy Evaluation Criteria", except for death, it is divided into 4 levels:

[0108] Recovery means that the strength of the limbs has returned to normal, and respiratory muscle paralysis and bulbar paralysis have disappeared;

[0109] Markedly effective, the degree of improvement reached a level where respiratory muscle paralysis and bulbar paralysis symptoms disappeared within 10 days;

[0110] Improvement means that muscle strength begins to recover and does not progress, and respiratory muscle paralysis and bulbar paralysis symptoms improve;

[0111] Ineffective means that muscle strength has not recovered or even worsens, and respiratory muscle paralysis and bulbar paralysis have not improved.

[0112] (5) Adverse reaction observation:

[0113] The skin and mucosal reactions, redness, swelling, itching, abnormal blood pressure and vomiting reactions were observed in the two groups during medication.

[0114] Clinical implementation effect

[0115] The comparison of the treatment effects among the three groups is shown in Tables 3 to 6.

[0116] Table 3: Comparison of ADL scores before and after treatment (points)

[0117]

[0118] Table 4: Comparison of limb motor function classification before and after treatment (example)

[0119]

[0120] Table 5: Comparison of limb sensory function grades before and after treatment (example)

[0121]

[0122] Table 6: Comparison of efficacy

[0123]

[0124] From the results in Tables 3 to 6, it can be seen that the therapeutic effects of treatment group 1 and treatment group 2 are significantly better than those of the control group, with a total effective rate of more than 95%, and the therapeutic effect of treatment group 2 is even better, with a total effective rate of more than 99%. No adverse reactions occurred in the three groups of the present invention.

[0125] Analysis of Chinese herbal medicine composition from the perspective of modern medicine

[0126] The traditional Chinese medicine composition of the present invention was analyzed by network pharmacology, and 25 GBS genes were found through the malacards database (https: / / www.malacards.org / ) through "Guillain-Barre Syndrome (GBS, MCID: GLL022, MIFTS: 59)", all of which were coding genes. For details, see Table 7.

[0127] Table 7: GBS25 gene-level description

[0128] Gene abbreviation or name describe PMP22 Peripheral Myelin Protein 22 MZ Myelin Protein Zero MBP Myelin Basic Protein TNF Tumor Necrosis Factor ALB Albumin IL17A Interleukin 17A HLA-DQB1 Major Histocompatibility Complex,Class II,DQ Beta 1 TNFRSF1B TNF Receptor Superfamily Member 1B HLA-DRB1 Major Histocompatibility Complex,Class II,DR Beta 1 GALE UDP-Galactose-4-Epimerase DAAM2 Dishevelled Associated Activator Of Morphogenesis 2 ICAM1 Intercellular Adhesion Molecule 1 GJB1 Gap Junction Protein Beta 1 HLA-DQA1 Major Histocompatibility Complex,Class II,DQ Alpha 1 HP Haptoglobin FCHO1 FCH And Mu Domain Containing Endocytic Adapter 1 TNFRSF1A TNF Receptor Superfamily Member 1A PMP2 Peripheral Myelin Protein 2 MOG Myelin Oligodendrocyte Glycoprotein PDHA1 Pyruvate Dehydrogenase E1 Subunit Alpha 1 HCRT Hypocretin Neuropeptide Precursor CD40LG CD40 Ligand CD1A CD1a Molecule FAS Fas Cell Surface Death Receptor ACP1 Acid Phosphatase 1

[0129] The Chinese medicine involved in the present invention was analyzed through the HERB database to explore the correspondence between the Chinese medicine composition of the present invention and the above 25 genes. According to the target ranking, the target situation of the Chinese medicine components involved in the present invention is shown in Table 8.

[0130] Table 8: Number of targets of the Chinese medicinal components of the present invention against GBS genes

[0131] Serial number traditional Chinese medicine Number of targets 1 Codonopsis pilosula 8 2 ginkgo 7 3 Eclipta prostrata 5 4 Scrophularia 4 5 Persimmon Leaves 4 6 Mulberry 4 7 Astragalus complanatus 4 8 Liu Jinu 4 9 purslane 4 10 Aloe Vera 4 11 malt 4 12 Wooden Butterfly 4 13 Herba Pogostemonis 4 14 Light black beans 4

[0132] As can be seen from the results in Table 7, the 14 components of the Chinese medicine composition of the present invention have multiple targets for the GBS coding gene, which shows that the present invention not only retains and strengthens the treatment idea of ​​strengthening the body and clearing away heat, but also explains the internal mechanism of the present invention to achieve higher efficacy from the perspective of modern pharmacology. At the same time, the present invention strengthens the inhibition strategy for pathogenic microorganisms in the acute infection period, and on the basis of strengthening the body, it can strengthen the effects of relieving lung surface wind evil in the acute period and nourishing yin, resolving phlegm and relieving constipation in the recovery period.

Claims

1. A Chinese medicinal composition for strengthening the body and clearing away heat for treating Guillain-Barré syndrome, characterized in that: The traditional Chinese medicine composition is prepared by weight: 10-14 parts of Codonopsis pilosula, 25-35 parts of Astragalus, 10-14 parts of Poria, 10-14 parts of Licorice, 10-14 parts of Ginkgo, 4-8 parts of Eclipta prostrata, 10-14 parts of Scrophularia ningpoensis, 8-12 parts of Salvia miltiorrhiza, 10-14 parts of Red Peony Root, 4-8 parts of Diospyros kaki leaves, 8-12 parts of Morus alba, 8-12 parts of Astragalus complanatus, 4-8 parts of Achyranthes bidentata, 8-12 parts of Portulaca oleracea, 8-12 parts of Aloe, 4-8 parts of malt, 4-8 parts of Oroxylum indica, 4-8 parts of Herba Discoloris, 10-14 parts of Fructus Sophorae Flavescentis and 7-11 parts of Phellodendron amurense.

2. A Chinese medicinal composition for strengthening the body and clearing away heat for treating Guillain-Barré syndrome according to claim 1, characterized in that: The Chinese medicine composition is prepared by weight: 12 parts of Codonopsis pilosula, 30 parts of Astragalus membranaceus, 12 parts of Poria cocos, 12 parts of Licorice, 12 parts of Ginkgo, 6 parts of Eclipta prostrata, 12 parts of Scrophularia ningpoensis, 10 parts of Salvia miltiorrhiza, 12 parts of Red Peony Root, 6 parts of Diospyros kaki leaves, 10 parts of Morus alba, 10 parts of Astragalus membranaceus, 6 parts of Achyranthes bidentata, 10 parts of Portulaca oleracea, 10 parts of Aloe, 6 parts of Malt, 6 parts of Oroxylum indica, 6 parts of Herba Potentillae, 12 parts of Fructus Sojae Indici and 9 parts of Phellodendron amurense.

3. A Chinese medicine hot compress pack for treating Guillain-Barré syndrome, comprising a Chinese medicine coating layer and a heating layer, characterized in that: The Chinese medicine coating layer is obtained by preparing the Chinese medicine composition according to claim 1 to obtain powder, and then packaging it; the heating layer includes a self-heating bag and a fumigation bag; in terms of mass fractions, the components of the self-heating bag include 50-60 parts of iron powder, 5-10 parts of activated carbon, 8-12 parts of sodium chloride, 10-15 parts of vermiculite, 30-40 parts of water and 1-4 parts of water-absorbing resin; The components of the fumigation bag include calcium bicarbonate and vermiculite, wherein the calcium bicarbonate is 20-40 parts and the vermiculite is 40-60 parts by weight.

4. A Chinese medicine hot compress pack for treating Guillain-Barré syndrome according to claim 3, characterized in that: The specific steps of preparing the Chinese medicine composition are as follows: The Chinese medicine composition is crushed, and soaked with an ethanol solution to obtain an immersion liquid, and the immersion liquid is crushed and filtered by high-pressure homogenization to obtain a filtrate and a filter residue respectively; The filtrate is subjected to rotary evaporation to obtain crystals, which are dried to obtain a Chinese medicine extract; Drying the filter residue; The Chinese medicinal extract and the filter residue are mixed and packaged or packaged separately.

5. A Chinese medicine hot compress pack for treating Guillain-Barré syndrome according to claim 4, characterized in that: The conditions for the high-pressure homogenization and crushing are homogenization at 850 bar to 1200 bar for 20 to 30 times; the mass concentration of the ethanol solution is 75% to 85%.

6. A Chinese medicine hot compress pack for treating Guillain-Barré syndrome according to claim 4, characterized in that: The mass ratio of the traditional Chinese medicine extract to the filter residue is 1 to 3:1.

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