A synergistic compound composition of two active components and its application

Abstract

The present invention belongs to the field of pesticides and relates to a synergistic compound composition containing two active components. The composition contains two active components A and B, wherein component A is selected from the following structural compounds and component B is selected from acaricides; the weight ratio of the two active components A and B is 1:50 to 50:1; the composition of the present invention has an obvious synergistic effect and can be used to prevent and control a variety of pests and mites.

Description

Technical Field

[0001] The invention belongs to the field of pesticides and relates to a synergistic compound composition of two active components and an application thereof. Background Art

[0002] The drugs used to control the damage of mites are collectively referred to as acaricides. Mites are small in size, reproduce quickly, have a short generation cycle, are highly adaptable, and are easy to develop drug resistance. They are one of the more difficult pest populations to control on crops such as fruit trees, vegetables, ornamental plants, and field crops. The application of chemical acaricides is the most effective means of controlling harmful mites, but the long-term continuous high-dose application of a single chemical acaricide can easily lead to a series of problems such as the development of drug resistance in harmful mites, drug residues, and environmental pollution. Reasonable compounding or mixing of chemical insecticides and acaricides has the positive characteristics of expanding the insecticide and acaricide spectrum, improving the control effect, extending the appropriate period for application, reducing the amount of medicine used, reducing drug damage, reducing residues, and delaying the occurrence and development of pest and mite resistance. Compounding or mixing of insecticides and acaricides is one of the most effective ways to solve the above problems. The price of developing new pesticides continues to rise. In contrast, the development and research of high-efficiency, low-toxic, low-residue compounds and mixtures have the advantages of low investment and short development cycle, and have attracted attention at home and abroad, and have increased their efforts in development and research.

[0003] Chinese invention patent CN112457288 discloses a piperic acid derivative and its application, wherein compound I-72 has contact and stomach poison activity and good conduction activity, and can be used to control a variety of Lepidoptera, Hemiptera, Thysanoptera, Coleoptera and other pests. The compound has the following structural formula:

[0004]

[0005] The combination of different ingredients may produce some unexpected technical effects and is also an effective method for preventing and controlling resistant pests. However, there is no report on the combination of compound I-72 and acaricide. Summary of the invention

[0006] The purpose of the present invention is to provide a synergistic compound composition of two active components and its application.

[0007] To achieve the above purpose, the technical solution adopted by the present invention is:

[0008] A synergistic composite composition of two active components, the composition comprises two active components A and B, component A is selected from a piperic acid derivative compound of the following structure (i.e., compound I-72), and component B is selected from acaricide; the weight ratio of the two active components of components A and B is 1:50 to 50:1; wherein the structural formula of the piperic acid derivative compound is as follows:

[0009]

[0010] The component B is a miticide selected from pyridaben, cyetpyrafen, fluacrypyrim, fenpyroximate, tebufenpyrad, cyenopyrafen, etoxazole, hexythiazox, clofentezine, propargite, bifenazate, cyflumetofen, azocyclotin, cyhexatin, fenbutatin, and fenbutatin. oxide), phenproxide, benzoximate, triarathene, dofenapyn, halfenprox, chloropropylate, dienochlor, flubenzimine, tazimcarb, phostin, dicofol, tetradifon, chlorfenethol, tetrasul, tetranactin, medimeform, aramite, chlorfenson, chlorfensulphide, genite, MNFA, cycloprate, Amidoflumet, fenazaflor, clenpirin, thioquinox, fenazaquin, binapacryl, fluenetil, dinocton, chlorbenside, cymiazole, morphothion, pyriminostrobin, pyrimidifen, acequinocyl, chinomethionat, chloromebuform, malonoben, bromocyclen, azobenzene, TEPP, dinosulfon, bromopropylate,Dinopenton, dinoterbon, prothidathion, dinex, dinobuton, chlorobenzilate, benoxafos, endosulfan, sulfur, DNOC, semiamitraz, amitraz, chlordimeform, formetanate, Flipper (bioacaricide containing C7-C20 fatty acids), pyflubumide, acynonapyr or trifluenfuronate.

[0011] Preferably, in the composition, component A is selected from the above-mentioned piperic acid derivative compounds; component B is selected from pyridaben, cyetpyrafen, fluacrypyrim, fenpyroximate, tebufenpyrad, cyenopyrafen, etoxazole, hexythiazox, clofentezine, propargite, bifenazate, cyflumetofen, azocyclotin, pyriminostrobin, pyrimidifen, acequinocyl, bromopropylate, pyflubumide, acynonapyr, trifluenfuronate;

[0012] The weight ratio of the two active components, component A and component B, is 1:20 to 20:1.

[0013] More preferably, in the composition, component A is selected from the above-mentioned piperic acid derivative compounds; component B is selected from pyridaben and cyetpyrafen;

[0014] The weight ratio of the two active components A and B is 1:10 to 10:1.

[0015] The application of the composition is used for preparing insecticides and miticides for preventing and controlling pests and mites on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops, shrubs, broad-leaved trees and evergreen trees.

[0016] The composition is used for preventing or controlling pests of the orders Acarina, Lepidoptera, Hemiptera, Homoptera, Coleoptera, Diptera, Thysanoptera, and larvae and eggs thereof.

[0017] The synergistic compound composition of the present invention has a significant synergistic effect in preventing and controlling pests and mites on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops, shrubs, broad-leaved trees, and evergreen trees. The results of indoor biological activity assays show that mixing compound I-72 with acaricides can improve the prevention effect, reduce the dosage, and expand the insecticide spectrum. For example, when compound I-72 is mixed with pyridaben in a ratio range of 1:10 to 10:1, the activity against spider mites can be greatly improved; therefore, the synergistic compound composition of the present invention can be used to prepare insecticides and acaricides.

[0018] The synergistic compound composition of the present invention can be used to control pests, mites, and underground pests on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops, shrubs, broad-leaved trees, evergreen trees, etc.; it can be particularly used in applications for controlling mites on crops, especially in applications for controlling mites on crops such as citrus, cotton, apples, flowers or vegetables.

[0019] In particular, the synergistic compound composition of the present invention is particularly useful for controlling pests of the order Acarina, a non-exhaustive list of which includes, but is not limited to, for example, Panonychus citri, Tetranychus cinnabarinus, Panonychus ulmi, Tetranychus urticae, Tetranychus viennensis, Oligonychus ununguis, Tetranychus citri, Tetranychus ulmi, Tetranychus urticae, Tetranychus viennensis, Tetranychus urticae ...

[0020] (Eotetranychus kankitus), Brevipalpus phoenicis, Bryobia praetiosa, Aceria tulipae, Colomerus vitis, Calacarus carinatus, Phyllocoptes oleivora ashmead, Polyphagotarsonemus latus, Rhizoglyphus rostochiensis, Acarus siro, Aceriasheldoni, Aculuss chlechtendali, Acalitus spp., Aculus spp., Acaricalus spp., Aceria spp.), Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia spp., Calipitrimerus spp., Chorioptes spp., Dermanyssus gallinae, Dermatophagoides spp., Eotetranychus spp., Eriophyes spp., Semitarsonema spp.

[0021] Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Olygonychus spp., Ornithodoros spp., Polyphagotarsone latus, Panonychus spp., Phyllocoptrutaoleivora, Phytophagous mites

[0022] Phytonemus spp., Polyphagotarsonemus spp., Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Steneotarsonemus spp., Tarsonemus spp., and Tetranychus spp., etc.

[0023] In particular, the synergistic compound composition of the present invention can be used to control citrus panonychus mite, citrus rust mite, citrus early spider mite, hawthorn spider mite, apple panonychus mite, two-spotted spider mite, tea yellow mite, tea orange gall mite, tea short-palped mite, tea gall mite, cinnabarinus spider mite, truncate spider mite, Turkestan spider mite, Dunhuang spider mite, wheat round red spider, wheat long-legged spider, jujube tick, citrus leaf miner, citrus scale insect, fruit tree leaf miner, Fruit borer, soybean borer, golden moth, tea geometrid, tea caterpillar, tea green leafhopper, pear psyllid, rice planthopper, greenhouse whitefly, American leafminer, yellow-striped flea beetle, striped stem borer, yellow stem borer, corn borer, bean pod borer, melon borer, rice water weevil, cotton bollworm, pink bollworm, fruit aphid, soybean aphid, vegetable aphid, wheat aphid, cotton aphid, diamondback moth, armyworm, cabbage worm, tobacco budworm, longhorn beetle and other pests and mites.

[0024] The synergistic compound composition of the present invention can be applied at an effective dose to the pests / mites to be controlled and / or their habitats. Therefore, the synergistic compound composition of the present invention provides a method for controlling or preventing plant pests.

[0025] The active ingredients in the synergistic compound composition of the present invention can be applied to pests, plants and their habitats simultaneously (for example, as a preformulated mixture or tank mix) or in a suitable sequence.

[0026] Advantages of the present invention: The binary composition obtained by compounding compound I-72 and acaricide in a suitable ratio has a good synergistic effect, thereby improving the prevention effect, reducing the dosage, and expanding the insecticide spectrum. Specifically, 1. The compounded two active components A and B have different mechanisms of action, which can delay the development of drug resistance in pests and mites. 2. The insecticide spectrum is expanded and can be used to prevent and control various pests and mites on various crops such as fruit trees, vegetables, ornamental plants, tea, and cotton; 3. The amount of pesticide used is reduced, the amount of pesticide residues on crops is reduced, and the friendliness to the environment is enhanced. 4. The two active components A and B are compounded within a suitable ratio range to improve the control effect of pests and mites. DETAILED DESCRIPTION

[0027] The following examples are used to explain the present invention in detail, so as to facilitate further understanding of the present invention. The active component A is selected from compound I-72 (prepared according to the description in the patent document CN112457288, with a content of 97%); the active component B and other raw materials are all commercially available products, and each component is measured by weight percentage.

[0028] Example 1: Indoor joint toxicity test of compound I-72 and pyridaben to Tetranychus cinnabarinus

[0029] Test target: Adult mites of Tetranychus cinnabarinus (boisduval), a sensitive strain reared indoors.

[0030] Preparation of drug solution: According to different test needs, use an electronic analytical balance to accurately weigh the test samples, dissolve the original drug in acetone, and then use 0.1% Tween 80 water to dilute it into a series of drug solutions with a certain concentration gradient according to the designed experimental dosage.

[0031] Test method: The potted seedling spray method was used to determine the activity against adult Tetranychus cinnabarinus. First, adult Tetranychus cinnabarinus mites of the same size were inoculated on the leaves of bean seedlings in the first pair of true leaves, and the base number was counted after the adult mites stabilized; then, according to the experimental design, the order from low dose to high dose was sprayed evenly, 1.5 mL per plant, 3 replicates per treatment, and a blank control was set.

[0032] The treated samples were placed in an observation room, where the temperature, humidity and light can be adjusted as needed. The number of dead and live mites was investigated after 72 hours. The corrected mortality rate was calculated using the Abbott formula, and statistical analysis was performed using the DPS data processing software to obtain the toxicity regression equations, LC values, and the toxicity of each single agent and each different ratio of the mixture. 50 The co-toxicity coefficient of each ratio was calculated by Sun Yunpei (Sun yp) method to evaluate the mixing effect. The test results are shown in Table 1.

[0033] The co-toxicity coefficient (CTC value) of the mixture is calculated according to the following formula:

[0034]

[0035] Where: ATI-actual toxicity index of the mixture; S-LC of the standard agent 50 ; LC of M-mixture 50 .

[0036] TTI=TIA×PA+TIB×PB

[0037] Where: TTI - theoretical toxicity index of the mixture; TIA - toxicity index of agent A; PA - percentage content of agent A in the mixture; TIB - toxicity index of agent B; PB - percentage content of agent B in the mixture.

[0038]

[0039] Where: CTC - co-toxicity coefficient; ATI - measured toxicity index of the mixture; TTI - theoretical toxicity index of the mixture.

[0040] The co-toxicity coefficient (CTC) of the compound mixture: CTC ≥ 120 indicates synergistic effect; 80 < CTC < 120 indicates additive effect; CTC ≤ 80 indicates antagonistic effect.

[0041] Table 1 Results of indoor joint toxicity determination of compound I72 and pyridaben against Tetranychus cinnabarinus

[0042]

[0043] Example 2: Indoor joint toxicity determination test of compound I-72 and cyazofamid against Tetranychus urticae

[0044] Test target: Adult mites of Tetranychus urticae Koch, sensitive strain reared indoors.

[0045] Preparation of liquid medicine: According to different test requirements, accurately weigh the test samples respectively with an electronic analytical balance. The technical materials are dissolved in acetone and then diluted with 0.1% Tween 80 water into a series of liquid medicines with a certain concentration gradient according to the test design dose.

[0046] Test method: The pot seedling spraying method was used to determine the activity against adult mites of Tetranychus urticae. First, adult mites of Tetranychus urticae with the same size were placed on the leaves of kidney bean seedlings at the stage of the first pair of true leaves spreading flat. After the adult mites were stable, the base number was counted. Then, according to the test design, uniform spraying was carried out in the order from low dose to high dose, 1.5 mL per plant, with 3 replicates for each treatment, and a blank control was set up.

[0047] The treated test materials were placed in an observation room, and the temperature, humidity, and light in the observation room could be adjusted as needed. After 72 hours, the number of dead and live mites was investigated. The corrected mortality was calculated using the Abbott formula, and statistical analysis was carried out using DPS data processing software to obtain the toxicity regression equations, LC 50 values and 95% confidence limits of each test single agent and each different ratio mixture. Then, the co-toxicity coefficients of each ratio were calculated using the Sun y-p method to evaluate the mixing effect (the same as in Example 1). The test results are shown in Table 2.

[0048] Table 2 Results of indoor joint toxicity determination of compound I72 and cyazofamid against Tetranychus urticae

[0049]

[0050]

[0051] The description of the above embodiments is only used to help understand the method of the present invention and its core idea. It should be pointed out that for ordinary technicians in this technical field, without departing from the principle of the present invention, the present invention can also be improved and modified in several ways, and these improvements and modifications also fall within the protection scope of the claims of the present invention. It can be seen from the above technical scheme that the insecticide and acaricide composition of the present invention has the advantages of improving drug efficacy, expanding insecticide spectrum, reducing the amount of pesticides used, reducing the amount of pesticide residues on crops, reducing environmental pollution, being safe for humans and animals, having good environmental compatibility, and pests are not easy to develop drug resistance. The composition of the present invention can be applied to the prevention and control of various pests and mites of various crops, and can be widely used in the field of agriculture.

Claims

1. A synergistic compound composition of two active ingredients, characterized in that: The composition comprises two active components A and B, wherein component A is selected from the piperic acid derivative compounds of the following structure, and component B is selected from cyetpyrafen; the weight ratio of the two active components A and B is 1:50 to 50:1; wherein the structural formula of the piperic acid derivative compounds is as follows: 。 2. The composition according to claim 1, characterized in that: The weight ratio of the two active components, component A and component B, is 1:20 to 20:

1.

3. The composition according to claim 2, characterized in that: The weight ratio of the two active components A and B is 1:10 to 10:

1.

4. Use of the composition according to claim 1, characterized in that: The composition is used for preparing acaricide medicine for preventing and controlling Acarina mites on fruit trees, vegetables, ornamental plants, tea, cotton, cereal crops, shrubs, broad-leaved trees and evergreen trees.

5. The use of the composition according to claim 4, characterized in that: The composition is used for preventing or controlling Acarina pests and their larvae and eggs.

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