A compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method

By using polysaccharide composite gel microsphere carriers, the problem of poor flowability of traditional Chinese medicine powder was solved, enabling effective deposition and antiviral effects of traditional Chinese medicine powder aerosol in the respiratory tract, and significantly improving the therapeutic effect.

CN118141855BActive Publication Date: 2026-05-26AFFILIATED HOSPITAL OF ZUNYI UNIV
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Patent Information

Application Number
CN202410319817.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-03-20
Publication Date
2026-05-26
Estimated Expiration
2044-03-20

AI Technical Summary

Technical Problem

After being micronized, traditional Chinese medicine tends to aggregate and has poor flowability, making it difficult to deposit at the site of respiratory infection, resulting in low absorption rate and reduced efficacy.

Method used

Polysaccharide composite gel microspheres were used as carriers for traditional Chinese medicine powders. Through cross-linking of seaweed sulfate polysaccharide, lentinan and curcumin, a three-dimensional network structure was formed, which enhanced the fluidity and adhesion. The microspheres also formed a complex with calcium chloride to improve antiviral activity, thus preparing a compound traditional Chinese medicine powder mist.

Benefits of technology

It improved the fluidity and deposition capacity of Chinese herbal medicine powder, enhanced its antiviral properties, improved its therapeutic effect, reduced the inflammatory response, and significantly enhanced its therapeutic effect on respiratory tract infections.

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Abstract

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.
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