Sample and reagent dispensing method, sample analyzer, and electronic device

Abstract

This application discloses a method for dispensing samples and reagents, comprising: controlling a first element to perform a sample dispensing action, dispensing a sample to be tested into a reaction vessel, the sample dispensing action including at least a sample input action and a sample output action; while controlling the first element to perform the sample dispensing action, controlling a second element to perform a reagent dispensing action, dispensing a detection reagent into the reaction vessel, the reagent dispensing action including at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are executed asynchronously. This method achieves parallel dispensing of samples and reagents, shortens the time consumed in the sample / reagent dispensing stage during sample detection, and improves the operating efficiency and sample detection speed of automated sample dispensing equipment.

Description

Technical Field

[0001] This application relates to the field of medical technology, and in particular to a method for dispensing samples and reagents, a sample analyzer, and electronic equipment. Background Technology

[0002] With the rapid development of medical testing technology, high-throughput testing equipment has been widely used. Among them, reaction cups, due to their combination of the high-throughput characteristics of plate reaction vessels and the flexibility of tubular reaction vessels, have become commonly used reaction containers in medical testing. In practical applications, reaction cups are usually placed in an eight-cup configuration in an automated sample dispensing device. The sample to be tested is dispensed into each of the eight cups by a sample dispensing element, and the test reagent is dispensed into each of the eight cups by a reagent dispensing element, thus completing the sample and reagent dispensing process.

[0003] Existing methods for dispensing samples and reagents into reaction vessels involve first dispensing samples according to their order of arrangement into the eight-cup reaction vessels. After sample dispensing, reagent dispensing is performed, dispensing each reagent into each of the eight reaction vessels according to its quantity. While this method is simple, it is inefficient, reducing the operational efficiency of automated sample dispensers and impacting detection speed. Summary of the Invention

[0004] This application provides a sample and reagent dispensing method, apparatus, and electronic instrument to solve the technical problems of low operating efficiency and slow detection speed of automatic sample dispensing equipment due to low sample / reagent dispensing efficiency in the prior art.

[0005] This application provides a method for dispensing samples and reagents. The method is applied to a detection device that dispenses a sample to be tested and a detection reagent into a reaction container within the same dispensing area. The reaction container is fixed in the dispensing area during the dispensing period of the sample to be tested and the detection reagent. The method includes:

[0006] The first element is controlled to perform a sample dispensing action, dispensing the sample to be tested into the reaction vessel. The sample dispensing action includes at least a sample input action and a sample output action.

[0007] During the process of controlling the first element to perform the sample dispensing action, the second element is controlled to perform the reagent dispensing action, dispensing the detection reagent into the reaction vessel. The reagent dispensing action includes at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are executed asynchronously.

[0008] Optionally, the first element performs the sample allocation action once by allocating one sample to be tested into one of the reaction vessels. Within a testing batch, the number of times the first element performs the sample allocation action is the same as the number of samples to be tested.

[0009] Optionally, the second element performs the reagent dispensing action once by dispensing one test reagent into multiple reaction vessels. Within a test batch, the number of times the second element performs the reagent dispensing action is the same as the number of test reagents.

[0010] Optionally, before the step of controlling the second element to perform the reagent dispensing action during the process of controlling the first element to perform the sample dispensing action, the method further includes:

[0011] Based on the detection items, a detection mode is determined. The detection model includes a normal mode and a rapid mode. In the rapid mode, the execution time of the first element performing the sample output action and the execution time of the second element performing the reagent output action overlap at least partially.

[0012] Based on the detection mode, the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action are determined, wherein the execution mode includes a continuous execution mode and an intermittent execution mode.

[0013] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode includes:

[0014] If the detection mode is normal mode, the first element performs the sample dispensing action in a continuous manner, and the second element performs the reagent dispensing action in a continuous manner.

[0015] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode further includes:

[0016] If the detection mode is a fast mode, the first element performs the sample dispensing action intermittently, and the second element performs the reagent dispensing action continuously.

[0017] Optionally, during the process of controlling the first element to perform the sample dispensing action, controlling the second element to perform the reagent dispensing action includes:

[0018] During the overlap time, the first element is controlled to pause the sample output action, and the second element is controlled to perform the reagent output action;

[0019] After the second element completes the reagent output action, it controls the first element to perform the sample output action.

[0020] Optionally, the first element is a sample dispensing element with a configurable disposable nozzle, and the sample dispensing action further includes: a first nozzle acquisition action and a first nozzle disposal action; the first element performs the sample dispensing action intermittently, including:

[0021] Before the overlap time, the first element moves to the gun head acquisition area and acquires the first gun head to complete the first gun head acquisition action;

[0022] During the overlap time, the first element that has acquired the first gun head moves to the sample acquisition area and uses the first gun head to pick up a preset volume of the sample to be tested, thereby completing the sample input action.

[0023] After the overlap time, the first element that has been input with the sample to be tested moves to the sample distribution area and distributes the sample to be tested into the reaction vessel to complete the sample output action;

[0024] After the sample output action is completed, the first element of the sample to be tested that has been output is moved to the nozzle discarding area and the first nozzle is discarded to complete the first nozzle discarding action.

[0025] The overlap time is the time corresponding to the second element performing the reagent output action.

[0026] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode further includes:

[0027] If the detection mode is a fast model, the first element performs the sample dispensing action continuously, and the second element performs the reagent dispensing action intermittently.

[0028] Optionally, during the process of controlling the first element to perform the sample dispensing action, controlling the second element to perform the reagent dispensing action includes:

[0029] During the overlap time, the second element is controlled to pause the reagent output action, and the first element is controlled to perform the sample output action;

[0030] After the first element completes the sample output action, the second element is controlled to perform the reagent output action.

[0031] Optionally, the second element is a reagent dispensing element with a configurable disposable pipette tip. The reagent dispensing action further includes: a second pipette tip acquisition action and a second pipette tip disposal action; the second element performs the reagent dispensing action intermittently, including:

[0032] Before the overlap time, the second element moves to the gun head acquisition area to acquire the second gun head, thereby completing the second gun head acquisition action;

[0033] After the second nozzle acquisition action is completed, the second element that has acquired the second nozzle moves to the reagent acquisition area and draws a preset volume of the detection reagent through the second nozzle to complete the reagent input action;

[0034] After the reagent input action is completed, the second element with the input test reagent moves to the sample dispensing area and dispenses a portion of the test reagent into the reaction container to complete the first sub-action of the reagent output action;

[0035] During the overlap time, the second element that has already partially output the detection reagent moves out of the sample dispensing area and enters a waiting state;

[0036] After the overlap time, the second element that has already output a portion of the detection reagent moves to the sample dispensing area and dispenses the remaining portion of the detection reagent into the reaction vessel to complete the second sub-action of the reagent output action;

[0037] After completing the second sub-action of the reagent output action, the second element that has output the test reagent moves to the nozzle discarding area and discards the second nozzle to complete the second nozzle discarding action;

[0038] The overlap time is the time corresponding to the first element performing the sample output action.

[0039] This application embodiment also provides a sample analyzer, which includes at least: a sample dispensing unit, a reagent dispensing unit, and an incubation unit;

[0040] The sample dispensing unit is used to control the first element to perform a sample dispensing action to dispense the sample to be tested into the reaction vessel. The sample dispensing action includes at least a sample input action and a sample output action.

[0041] The reagent dispensing unit is used to control the second element to perform a reagent dispensing action during the process of the sample dispensing unit controlling the first element to perform the sample dispensing action, dispensing the detection reagent into the reaction container. The reagent dispensing action includes at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are mutually exclusive.

[0042] The incubation unit is used to place the reaction container. The reaction container is fixed in the incubation unit during the distribution period of the sample to be tested and the test reagent. The sample distribution unit distributes the sample to be tested into multiple reaction containers by moving in the incubation unit. The reagent distribution unit distributes the test reagent into multiple reaction containers by moving in the incubation unit.

[0043] This application also provides an electronic device, including: a storage module and an execution module;

[0044] The storage module is used to store one or more computer instructions;

[0045] The execution module is used to execute one or more computer instructions to implement the above method.

[0046] Compared with existing technologies, the sample and reagent dispensing method provided in this application includes: controlling a first element to perform a sample dispensing action, dispensing the sample to be tested into a reaction vessel, wherein the sample dispensing action includes at least a sample input action and a sample output action; while controlling the first element to perform the sample dispensing action, controlling a second element to perform a reagent dispensing action, dispensing the detection reagent into the reaction vessel, wherein the reagent dispensing action includes at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are executed asynchronously. This method, by controlling the second element to perform the reagent dispensing action while controlling the first element to perform the sample dispensing action, enables the sample dispensing action and reagent dispensing action to partially overlap in time, shortening the total time consumed by sample and reagent dispensing and improving sample / reagent dispensing efficiency. The sample and reagent dispensing method provided in this application realizes parallel dispensing of samples and reagents, transforming the sequential sample and reagent dispensing in existing technologies into synchronous execution, shortening the time consumed in the sample / reagent dispensing stage during sample detection, and improving the operating efficiency and sample detection speed of the automatic sample dispensing equipment. Attached Figure Description

[0047] Figure 1 This is a schematic diagram of a cup that should be connected;

[0048] Figure 2 This is a partial structural diagram of a sample dispensing device;

[0049] Figure 3 This is a schematic diagram of an existing sample and reagent dispensing method provided in the embodiments of this application;

[0050] Figure 4 This is an application system diagram of a sample and reagent dispensing method provided in an embodiment of this application;

[0051] Figure 5 This is a flowchart of the sample and reagent dispensing method provided in the first embodiment of this application;

[0052] Figure 6 This is a schematic diagram of the sample and reagent dispensing method provided in the first experimental example of this application;

[0053] Figure 7 This is a schematic diagram of the sample and reagent dispensing method provided in the second experimental example of this application;

[0054] Figure 8 This is a schematic diagram of the sample and reagent dispensing method provided in the third experimental example of this application;

[0055] Figure 9 This is a schematic diagram of the sample and reagent dispensing method provided in the fourth test example of this application;

[0056] Figure 10 This is a schematic diagram of the sample and reagent dispensing method provided in the fifth test example of this application;

[0057] Figure 11 This is a schematic diagram of the sample and reagent dispensing method provided in the sixth test example of this application;

[0058] Figure 12 This is a schematic diagram of the sample analyzer provided in the fourth embodiment of this application;

[0059] Figure 13 This is a schematic diagram of the structure of the electronic device provided in the fifth embodiment of this application. Detailed Implementation

[0060] Many specific details are set forth in the following description to provide a full understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of this application; therefore, this application is not limited to the specific embodiments disclosed below.

[0061] The following explanations of some technical terms used in the embodiments of this application are provided to facilitate understanding.

[0062] A sample refers to a subset of individuals drawn from a population. A sample is typically representative of the population, and population data can be obtained through observation or testing of the sample data. In the field of medical testing, a sample refers to a portion of tissue or metabolic products obtained from a living organism. Examples include skin tissue samples, blood samples, and hair samples.

[0063] The aforementioned reaction cup is a reaction vessel used for sample detection. Each reaction vessel is cup-shaped with a certain capacity; connecting several cup-shaped reaction vessels together constitutes a reaction cup. Currently, the commonly used reaction cup is an eight-cup combination, but the number of cups can be adjusted according to updates to the detection instrument or sample loading equipment. Because it combines the high-throughput characteristics of plate reaction vessels with the flexibility of tubular reaction vessels, the reaction cup has become a commonly used reaction vessel in high-throughput detection.

[0064] The reaction cup refers to a single reaction vessel that makes up the reaction cup chain. It has a certain capacity. The sample and detection reagent are added to the reaction cup according to the detection requirements, and the reaction takes place in the reaction cup to form features that can be detected by the detection instrument.

[0065] The sample testing refers to the testing of collected samples, such as performing routine blood tests, liver and kidney function tests, blood lipid and blood glucose tests, and hepatitis B five-item tests on collected blood samples. Different testing reagents and methods are required for different tests on a single sample.

[0066] With the rapid development of medical testing technology, manual sample testing has been replaced by high-throughput testing equipment. Currently, the reaction vessels used in high-throughput testing equipment are mainly plate reaction vessels, such as 96-well plates and 48-well plates. The number of wells in a plate reaction vessel is fixed; not every sample test requires a large number of wells, often leading to excessive waste of the reaction vessel. For example, if a test requires a 96-well plate but only 10 wells are needed, one 96-well plate must still be used. Furthermore, once used, even if there are many unused wells, the plate cannot be reused. Therefore, continuous reaction cups, combining the high-throughput characteristics of plate reaction vessels with the flexibility of tubular reaction vessels, have gradually become the commonly used reaction vessel in high-throughput testing.

[0067] Figure 1 This is a schematic diagram of a reaction vessel.

[0068] like Figure 1As shown, a reaction vessel is a slatted reaction container composed of multiple reaction vessels connected and arranged together. An eight-cup reaction vessel is currently a common type. With the continuous upgrading of detection instruments and sample loading equipment, the number of reaction vessels in a reaction vessel system will also change. For example, for detections with smaller reaction volumes, the capacity of the reaction vessels in the reaction vessel system can be reduced, while the number of reaction vessels can be increased. Conversely, for detections with larger reaction volumes (currently requiring a tubular reaction vessel), the capacity of the reaction vessels in the reaction vessel system can be increased, while the number of reaction vessels can be decreased. Of course, changes in the capacity and number of reaction vessels in a reaction vessel system require corresponding updates to the sample loading equipment and detection instruments.

[0069] Figure 2 The diagram shows a partial structural schematic of a sample addition device in the prior art, which is derived from Chinese patent application number 201310167162.X.

[0070] In this embodiment, the method steps of this application are illustrated using the prior art as an example. However, the method of this application is not limited to application on the sample loading device of the prior art, but can be applied to any sample loading device with similar hardware settings, that is, a sample loading device in which the reagent arm and the sample arm share a fixed incubation area.

[0071] like Figure 2 As shown, the sample dispensing device includes at least a reaction vessel placement assembly 201, a sample dispensing assembly 202, and a reagent dispensing assembly 203. The reaction vessel placement assembly 201 is primarily used to place the reaction vessels and is moved by a push rod. The sample dispensing assembly 202 dispenses the sample to be tested into the reaction vessel within the reaction vessel. The reagent dispensing assembly 203 dispenses the detection reagent into the reaction vessel within the reaction vessel. Both the sample dispensing assembly 202 and the reagent dispensing assembly 203 can be configured with disposable pipette tips. After dispensing one type of sample or detection reagent, the pipette tip is discarded, and a new tip is configured for dispensing another type of sample or detection reagent.

[0072] The following is Figure 2 Using the sample dispensing device shown as an example, this paper explains the method of dispensing the sample to be tested and the test reagent in existing sample detection methods.

[0073] Existing sample and reagent dispensing methods typically employ a sample dispensing component to dispense the sample to be tested into the reaction vessel, followed by a reagent dispensing component to dispense the test reagents into the reaction vessel.

[0074] Taking an eight-cup test as an example, this paper explains the sample and reagent allocation method in existing sample testing methods. Assume there are eight samples to be tested (denoted as A1 to A8), each sample undergoes only one test, and there are two types of test reagents (denoted as R1 and R2). Each sample requires a mixture of both test reagents before testing. The sample and reagent allocation steps are as follows:

[0075] Step 1: Push the eight cups to the sample distribution area.

[0076] Step 2: The sample distribution component moves to the nozzle acquisition area to acquire the nozzle.

[0077] Step 3: The sample dispensing component moves to the sample acquisition area, performs liquid level detection on the sample A1 to be tested, and aspirates the sample A1.

[0078] Step 4: The sample dispensing component moves to the sample dispensing area and dispenses the sample A1 to be tested into reaction cup number 1 of the eight-cup container.

[0079] Step 5: The sample dispensing component moves to the nozzle discarding area and discards the nozzle.

[0080] Step 6: Repeat steps 2 to 5 to complete the distribution of the remaining 7 samples to be tested, and distribute the remaining 7 samples to reaction cups 2 to 8 of the eight-cup system.

[0081] Step 7: The reagent dispensing component moves to the pipette tip acquisition area to acquire the pipette tip.

[0082] Step 8: The reagent dispensing component moves to the reagent acquisition area, detects the liquid level of the test reagent R1, and aspirates the test reagent R1.

[0083] Step 9: The reagent dispensing assembly moves to the sample dispensing area and dispenses the test reagent R1 into each of the eight reaction cups using a one-to-eight dispensing method.

[0084] Step 10: The reagent dispensing unit moves to the pipette tip disposal area and discards the pipette tip.

[0085] Step 11: Repeat steps 7 to 10 to complete the dispensing of test reagent R2.

[0086] Step 12: Push the eight cups into the sample incubation area.

[0087] In other words, in the existing technology, the above 12 steps are required to complete the distribution of 8 samples to be tested and 2 types of test reagents.

[0088] Figure 3 This is a schematic diagram of an existing sample and reagent dispensing method provided in the embodiments of this application.

[0089] like Figure 3 As shown, in existing sample and reagent dispensing methods, step 1 is performed first to move the eight-cup container to the sample dispensing area; then steps 2 to 5 are repeated eight times to dispense the eight samples to be tested (A1-A8); then steps 7 to 10 are repeated twice to dispense the two test reagents R1 and R2 into the eight reaction cups; finally, step 12 is performed to move the eight-cup container to the sample incubation area. This process is simple, but the overall time consumption is too long.

[0090] Since the sample dispensing component performs steps 2 to 5 once, it actually dispenses only one sample to one reaction vessel, while the reagent dispensing component performs steps 7 to 10 once, it actually dispenses one detection reagent to eight reaction vessels. Therefore, dispensing one detection reagent takes longer than dispensing one sample. Based on this, assumptions are made regarding the sample dispensing time (required time), reagent dispensing time, and time for pushing the eight-cup reaction vessel, as shown in Table 1:

[0091] Table 1. Time Consumption of Allocation Actions (Primary Technology)

[0092] Execute action Time elapsed (seconds) Sample allocation action 9 Reagent dispensing action 19 Pushing action 2

[0093] Combined with Table 1, Figure 3 Based on the above allocation steps, the total time required to allocate 8 samples to be tested and 2 types of test reagents using existing sample and reagent allocation methods is shown in Table 2.

[0094] Table 2. Sample / Reagent Dispensing Time (Prior Art)

[0095]

[0096]

[0097] As shown in Table 2, using the existing sample and reagent dispensing method, the total time to dispense 8 samples and 2 reagents is 114 seconds. If the reaction cup placement assembly can hold 8 eight-cup cups at a time, then the detection throughput is 252 tests / hour.

[0098] The detection throughput can be understood as the amount of data that can be generated per unit time, and the calculation formula is:

[0099]

[0100] It should be noted that the above assumptions regarding the time required for sample allocation and reagent allocation are only for the purpose of understanding the methods described in this application, and are not intended to limit the time required for sample allocation and reagent allocation in real-world scenarios.

[0101] In view of the existing sample and reagent dispensing methods, this application provides a new sample and reagent dispensing method. By controlling the second element (reagent dispensing component) to perform reagent dispensing actions while the first element (sample dispensing component) performs the sample dispensing action, the sample dispensing action and the reagent dispensing action can partially overlap in time, thereby shortening the total time spent on sample dispensing and reagent dispensing and improving the sample / reagent dispensing efficiency.

[0102] The following detailed description, in conjunction with specific embodiments and accompanying drawings, further illustrates the sample and reagent dispensing method, apparatus, and electronic instruments described in this application. The following description will use a reaction vessel as the reaction container.

[0103] Figure 4 This is an application system diagram of a sample and reagent dispensing method provided in an embodiment of this application. For example... Figure 4 As shown, the application system includes a control terminal 401, an execution terminal 402, and a detection terminal 403, which are electrically connected. The control terminal 401 is equipped with the sample and reagent dispensing method provided in this application, and controls the execution terminal 402 to perform the dispensing action of the sample to be tested and the detection reagent through the method. The execution terminal 402, controlled by the control terminal 401, dispenses the sample to be tested and the detection reagent into the reaction vessel. The detection terminal 403 performs quantitative or qualitative detection on the mixture of the sample to be tested and the detection reagent in the reaction vessel and outputs the detection result. The control terminal 401, the execution terminal 402, and the detection terminal 403 can be installed in a single detection instrument as different modules, each performing its own function. Alternatively, the control terminal 401, the execution terminal 402, and the detection terminal 403 can also be used as separate devices, achieving sample detection through network connection, electrical connection, mechanical connection, etc. For example: the control terminal 401 can be a computer terminal, such as a laptop, desktop computer, smartphone, tablet computer, etc.; the execution terminal 402 can be an automatic sample dispensing device, controlled by the control terminal 401, to dispense the sample to be tested and the test reagent into the reaction vessel; the detection terminal 403 can be a detection device to perform quantitative and qualitative detection on the reactants in the reaction vessel.

[0104] The first embodiment of this application provides a method for dispensing samples and reagents. This method is applied to a detection device that dispenses a sample to be tested and a detection reagent into a reaction container within the same dispensing area. The reaction container is fixed in the dispensing area during the dispensing period of the sample to be tested and the detection reagent. For example: Figure 2The detection device shown has reaction cups fixed on the reaction cup placement assembly during the sample and reagent dispensing stage. The sample dispensing assembly and reagent dispensing assembly move on the reaction cup placement assembly to dispense the sample to be tested and the test reagent into each reaction cup of the reaction cups.

[0105] Figure 5 This is a flowchart of the sample and reagent dispensing method provided in this embodiment. The following is in conjunction with... Figure 5 The sample and reagent dispensing method provided in this embodiment is described in detail. The embodiments described below are used to explain the technical solutions of this application and are not intended to limit actual use.

[0106] like Figure 5 As shown, the sample and reagent dispensing method provided in this embodiment includes the following steps:

[0107] Step S501: Control the first element to perform a sample dispensing action to dispense the sample to be tested into the reaction vessel of the reaction vessel. The sample dispensing action includes at least a sample input action and a sample output action.

[0108] The first element can be understood as a component in the detection device that performs sample dispensing, that is, a sample dispensing component. The consumables configured in the first element can be disposable pipette tips or fixedly installed aspiration needles.

[0109] The sample allocation action can be understood as the action performed by the first element when performing sample allocation, mainly including sample input action and sample output action.

[0110] The sample input action can be understood as the action of the first element moving to the sample acquisition area, performing liquid level detection and absorbing the sample. The first element needs to perform liquid level detection before absorbing the sample, mainly because the sample will gradually decrease as it is distributed, and the sample liquid level will also gradually decrease. If there is no liquid level detection step, there will be problems such as not being able to absorb the sample or not absorbing enough sample volume, which will affect the detection results.

[0111] The sample output action can be understood as the action of the first element moving to the sample distribution area and distributing the sample into the reaction vessel of the reaction vessel.

[0112] In existing technologies, sample allocation also involves sample input and output, but the sample allocation action is not clearly divided. In the sample and reagent allocation method provided in this embodiment, the sample allocation action is broken down into sample input and sample output actions, making the sample and reagent allocation process more detailed. In this application, this division of sub-actions is achieved through time division. That is, in this application, the long time period corresponding to the sample allocation action in the existing controller is divided into multiple sub-time periods corresponding to the sample input and sample output actions.

[0113] In one optional implementation of this embodiment, the first element is a sample dispensing element with a configurable disposable nozzle. To avoid cross-contamination between different samples during sample dispensing, a new nozzle needs to be used after dispensing one sample before dispensing another. Therefore, the sample dispensing action includes, in addition to sample input and sample output actions, a first nozzle acquisition action and a first nozzle discard action.

[0114] The first gunhead acquisition action can be understood as the action of the first element moving to the gunhead acquisition area and acquiring the gunhead. The first gunhead discarding action can be understood as the action of the first element moving to the gunhead discarding area and discarding the gunhead.

[0115] Therefore, in the optional implementation provided in this embodiment, the sample allocation action performed by the first element includes four sub-actions, executed in the following order: first nozzle acquisition action, sample input action, sample output action, and first nozzle discard action. Specifically:

[0116] First, the first element moves to the gun head acquisition area to acquire the first gun head, thereby completing the first gun head acquisition action.

[0117] Second, the first element that has acquired the first nozzle moves to the sample acquisition area and uses the first nozzle to pick up a preset volume of the sample to be tested, thereby completing the sample input action.

[0118] Third, the first element, which has been input with the sample to be tested, moves to the sample distribution area and distributes the sample to be tested into the reaction vessel of the reaction vessel to complete the sample output action.

[0119] Fourth, the first element of the sample to be tested, which has been output, moves to the nozzle discarding area and discards the first nozzle to complete the first nozzle discarding action.

[0120] The first element completes the allocation of the sample to be tested by executing the above four sub-actions.

[0121] In another optional implementation provided in this embodiment, the first element is a sample dispensing element equipped with a fixedly mounted aspiration needle. In this case, the tip acquisition and tip discarding actions can be replaced by a needle cleaning action.

[0122] In another optional implementation provided in this embodiment, the first element performing the sample allocation action once is the action of allocating a sample to be tested into one of the reaction vessels, such as allocating a sample to be tested into one of the reaction vessels in a reaction vessel chain. That is, the first element completes the above four sub-actions once in the execution order, thereby completing the allocation of a sample to be tested and allocating the sample to be tested into one of the reaction vessels in a reaction vessel chain. Within a detection batch, the number of times the first element performs the sample allocation action is the same as the number of samples to be tested. For example, in a detection batch, there are three samples to be tested, namely sample A1, sample A2, and sample A3. The first element can allocate sample A1 to reaction vessel No. 1 of the eight-cup chain, sample A2 to reaction vessel No. 2 of the eight-cup chain, and sample A3 to reaction vessel No. 3 of the eight-cup chain by performing the above four sub-actions three times.

[0123] Step S502: During the process of controlling the first element to perform the sample dispensing action, the second element is controlled to perform the reagent dispensing action to dispense the detection reagent into the reaction cup of the reaction vessel. The reagent dispensing action includes at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are executed asynchronously.

[0124] The second element can be understood as a component in the detection device that performs the dispensing of detection reagents, that is, a reagent dispensing component. The consumables configured in the second element can be disposable pipette tips or non-disposable fixed aspiration needles.

[0125] The reagent dispensing action can be understood as the action performed by the second element when dispensing the detection reagent, mainly including the reagent input action and the reagent output action.

[0126] The reagent input action can be understood as the action of the second element moving to the reagent acquisition area to detect the liquid level and absorb the reagent.

[0127] The reagent output action can be understood as the action of the second element moving to the detection reagent distribution area and distributing the detection reagent into the reaction cup of the reaction vessel. In this embodiment, both the sample to be tested and the detection reagent are distributed in one distribution area, which is uniformly defined as the sample distribution area.

[0128] In the prior art, the distribution of test reagents, like the distribution of samples, also involves an input and output process, but the reagent distribution action is not clearly divided. In the sample and reagent distribution method provided in this embodiment, the reagent distribution action is broken down into reagent input action and reagent output action, making the sample and reagent distribution process more detailed.

[0129] Similar to the division of sample dispensing actions, this application divides the long time period corresponding to reagent dispensing actions in the prior art controller into multiple sub-time periods corresponding to reagent input actions and reagent output actions.

[0130] In one optional implementation of this embodiment, the second element includes a reagent dispensing element with a configurable disposable tip. Similarly, to avoid cross-contamination between different tests during reagent dispensing, a new tip needs to be replaced after dispensing one test reagent before dispensing another. Therefore, the reagent dispensing action further includes a second tip acquisition action and a second tip disposal action.

[0131] The second gunhead acquisition action can be understood as the second element moving to the gunhead acquisition area and acquiring the gunhead. The second gunhead discarding action can be understood as the second element moving to the gunhead discarding area and discarding the gunhead. The gunhead acquisition area and gunhead discarding area corresponding to the second gunhead acquisition action can be the same area or different areas as the gunhead acquisition area and gunhead discarding area corresponding to the first gunhead acquisition action; no restriction is placed here.

[0132] Therefore, in the optional implementation provided in this embodiment, the reagent dispensing action performed by the second element includes four sub-actions, executed in the following order: second nozzle acquisition action, reagent input action, reagent output action, and second nozzle discard action, specifically:

[0133] First, the second element moves to the gun head acquisition area to acquire the second gun head, thereby completing the second gun head acquisition action.

[0134] Second, the second element with the second nozzle moved to the reagent acquisition area and drew a preset volume of the detection reagent through the second nozzle to complete the reagent input action.

[0135] Third, the second element, into which the detection reagent has been input, moves to the sample dispensing area and dispenses the detection reagent into the reaction cup of the reaction vessel to complete the reagent output action.

[0136] Fourth, the second element that has output the test reagent moves to the nozzle discarding area and discards the second nozzle to complete the second nozzle discarding action.

[0137] The second element completes the dispensing of the detection reagent by performing the above four sub-actions.

[0138] In another optional implementation provided in this embodiment, the second element is a reagent dispensing element equipped with a fixedly mounted aspiration needle. In this case, the tip acquisition and tip disposal actions can be replaced by a needle cleaning action.

[0139] In another optional implementation provided in this embodiment, the second element performs the reagent dispensing action once by dispensing one test reagent into multiple reaction vessels, such as dispensing one test reagent into multiple reaction cups in a reaction vessel set. That is, the second element completes the above four sub-actions once in the execution sequence, thus dispensing one test reagent into multiple reaction cups in the reaction vessel set. This can be achieved through a one-to-many dispensing method, which not only reduces the number of reagent dispensing actions but also reduces the wear and tear on the pipette tip. Within a test batch, the number of times the second element performs the reagent dispensing action is the same as the number of test reagents. For example, in a test batch containing two test reagents, test reagent R1 and test reagent R2, the second element can dispense test reagent R1 into reaction cups 1 to 8 of an eight-cup set by performing the above four sub-actions twice, and dispense test reagent R2 into reaction cups 1 to 8 of the eight-cup set using the one-to-many dispensing method. If the reagents are not dispensed using a single aspiration and multiple dispensing method, it would require 16 of the above four sub-actions and consume 16 pipette tips to complete the dispensing of reagents R1 and R2 into the eight reaction cups of the eight-cup.

[0140] In the prior art, the second element performs the reagent dispensing action only after the first element completes the sample dispensing action. However, in the sample and reagent dispensing method provided in this embodiment, the second element performs the reagent dispensing action while the first element is performing the sample dispensing action, so that the sample dispensing action and the reagent dispensing action partially overlap in time, thereby shortening the total time spent on sample and reagent dispensing.

[0141] In this embodiment, the sample allocation and reagent allocation actions are separated, which is a prerequisite for achieving overlap between the sample allocation and reagent allocation actions. The first pipette tip acquisition, sample input, and first pipette tip discarding actions within the sample allocation action, and the second pipette tip acquisition, reagent input, and second pipette tip discarding actions within the reagent allocation action, can all be executed in different areas. Therefore, these actions do not overlap and can be executed synchronously. For example, when the first element performs the pipette tip acquisition action, the second element can perform the second pipette tip acquisition action, the reagent input action, or the second pipette tip discarding action. Similarly, when the second element performs the reagent input action, the first element can perform the first pipette tip acquisition action, the sample input action, or the first pipette tip discarding action. However, the sample output action within the sample allocation action and the reagent output action within the reagent allocation action both need to be completed in the sample allocation area. Therefore, the sample output action and the reagent output action cannot be executed synchronously; they are mutually exclusive actions and are executed asynchronously. However, the sample output action and the reagent output action are not mutually exclusive with other sub-actions and can be executed synchronously. For example: when the first element performs the sample output action, the second element can perform the second pipette tip acquisition action, reagent input action, and second pipette tip disposal action. As another example: when the second element performs the reagent output action, the first element can perform the first pipette tip acquisition action, sample input action, and first pipette tip disposal action.

[0142] In practical applications, not all testing items require rapid testing. Therefore, in an optional implementation provided in this embodiment, before controlling the second element to perform the reagent dispensing action during the process of controlling the first element to perform the sample dispensing action, the method further includes: determining a testing mode based on the testing item, wherein the testing mode includes a normal mode and a rapid mode, wherein in the rapid mode, the execution time of the first element performing the sample output action and the execution time of the second element performing the reagent output action overlap at least partially; and determining the execution method of the first element performing the sample dispensing action and the execution method of the second element performing the reagent dispensing action based on the testing mode, wherein the execution method includes a continuous execution method and an intermittent execution method.

[0143] The continuous execution method can be understood as the first element continuously performing sample dispensing actions, or the second element continuously performing reagent dispensing actions, without needing to pause during the execution process.

[0144] The intermittent execution mode can be understood as the first element pausing execution during the sample dispensing process, or the second element pausing execution during the reagent dispensing process.

[0145] Based on the detection mode, the execution methods for the first element to perform sample dispensing and the second element to perform reagent dispensing are determined as follows:

[0146] Firstly, if the detection mode is a normal mode, the first element performs the sample dispensing action in a continuous manner, and the second element performs the reagent dispensing action in a continuous manner.

[0147] For example, if the second element performs the reagent output action after the first element completes the sample output action, then the first element can continue to perform the sample output action and the subsequent first nozzle discard action, and the second element can also continue to perform the reagent output action.

[0148] Secondly, if the detection mode is a rapid mode, the first element performs the sample dispensing action intermittently, and the second element performs the reagent dispensing action continuously.

[0149] The specific implementation method is as follows:

[0150] First, during the overlap time, the first element is controlled to pause the sample output action, and the second element is controlled to perform the reagent output action.

[0151] Second, after the second element completes the reagent output action, the first element is controlled to perform the sample output action.

[0152] For example, if the first element performs a sample output action precisely while the second element performs a reagent output action, then the first element can be controlled to extend the waiting time for either the sample input or output action. The first element can then perform the sample output action after the second element completes its reagent output action. Alternatively, if the second element performs a reagent output action precisely while the first element performs a sample output action, then the first element can be controlled to pause its sample output action, while the second element performs its reagent output action. The first element can then perform its sample output action after the second element completes its reagent output action.

[0153] Based on this, this embodiment provides a method for an optional first element to perform sample allocation operations in an intermittent manner, including the following steps:

[0154] Step S11: Before the overlap time, the first element moves to the gun head acquisition area to acquire the first gun head, thereby completing the first gun head acquisition action.

[0155] In step S12, during the overlap time, the first element that has acquired the first gun head moves to the sample acquisition area and uses the first gun head to pick up a preset volume of the sample to be tested, thereby completing the sample input action.

[0156] Step S13: After the overlap time, the first element that has been input with the sample to be tested moves to the sample distribution area and distributes the sample to be tested into the reaction vessel to complete the sample output action.

[0157] Step S14: After completing the sample output action, the first element of the sample to be tested that has been output is moved to the gun head discarding area and the first gun head is discarded to complete the first gun head discarding action.

[0158] It should be noted that since the first element performs the sample dispensing action intermittently, while the second element performs the reagent dispensing action continuously, the aforementioned overlap time is the time corresponding to the second element performing the reagent output action.

[0159] Typically, the time it takes for the second element to perform the reagent output action is longer than the time it takes for the first element to perform the sample input action. Therefore, during the overlapping time, the first element will enter a waiting state within a preset time period.

[0160] Third, if the detection mode is a rapid model, the first element performs the sample dispensing action continuously, and the second element performs the reagent dispensing action intermittently.

[0161] The specific implementation method is as follows:

[0162] First, during the overlap time, the second element is controlled to pause the execution of the reagent output action, and the first element is controlled to execute the sample output action.

[0163] Second, after the first element completes the sample output action, the second element is controlled to perform the reagent output action.

[0164] For example, if the second element performs the reagent output action precisely while the first element is performing the sample output action, then the second element can be controlled to extend the waiting time for the reagent output action. The second element can then perform the reagent output action only after the first element has completed its sample output action. Alternatively, if the first element performs the sample output action precisely while the second element is performing the reagent output action, then the second element can be controlled to pause the reagent output action, while the first element performs the sample output action. The second element can then perform the reagent output action only after the first element has completed its sample output action.

[0165] Based on this, this embodiment provides a method for an optional second element to perform reagent dispensing operations in an intermittent manner, including the following steps:

[0166] Step S21: Before the overlap time, the second element moves to the gun head acquisition area to acquire the second gun head, thereby completing the second gun head acquisition action.

[0167] Step S22: After completing the second nozzle acquisition action, the second element with the acquired second nozzle moves to the reagent acquisition area and draws a preset volume of the detection reagent through the second nozzle to complete the reagent input action.

[0168] Step S23: After completing the reagent input action, the second element with the input test reagent moves to the sample distribution area and distributes a portion of the test reagent into the reaction container to complete the first sub-action of the reagent output action.

[0169] In step S24, during the overlap time, the second element that has already output part of the detection reagent moves out of the sample distribution area and enters a waiting state.

[0170] Step S25: After the overlap time, the second element that has already output part of the detection reagent moves to the sample dispensing area and dispenses the remaining part of the detection reagent into the reaction container to complete the second sub-action of the reagent output action.

[0171] Step S26: After completing the second sub-action of the reagent output action, the second element that has output the test reagent moves to the nozzle discarding area and discards the second nozzle to complete the second nozzle discarding action.

[0172] It should be noted that since the second element performs the reagent dispensing action intermittently, while the first element performs the sample dispensing action continuously, the aforementioned overlap time is the time corresponding to the first element performing the sample output action.

[0173] The first element performs a sample dispensing action by dispensing one sample to be tested into one reaction vessel, while the second element performs a reagent dispensing action by dispensing one reagent into multiple reaction vessels. Therefore, the time taken for a reagent dispensing action is much longer than the time taken for a sample dispensing action. Based on this, a reagent output action may require more than one pause; multiple pauses may be necessary. Thus, a single reagent output action may include multiple sub-actions, such as a first sub-action, a second sub-action, a third sub-action, etc. The first embodiment described above provides a sample and reagent dispensing method that allows the sample dispensing action and reagent dispensing action to partially overlap in time, shortening the total time spent on sample and reagent dispensing and improving sample / reagent dispensing efficiency. Of course, the sample and reagent dispensing method provided in this application includes, but is not limited to, the implementation method provided in the first embodiment of this application.

[0174] The second embodiment of this application provides a method for distributing samples and reagents, and the method described in this application will be explained in detail through specific examples.

[0175] According to the sample and reagent distribution method provided in the first embodiment of this application, the sample distribution action is divided into a first pipette tip acquisition action, a sample input action, a sample output action, and a first pipette tip discarding action; the reagent distribution action is divided into a second pipette tip acquisition action, a reagent input action, a reagent output action, and a second pipette tip discarding action. Based on the execution time of each sub-action in actual application scenarios, the time consumption of the sample distribution action shown in Table 1 is divided into the first pipette tip acquisition action, the sample input action, the sample output action, and the first pipette tip discarding action; and the time consumption of the reagent distribution action shown in Table 1 is divided into the second pipette tip acquisition action, the reagent input action, the reagent output action, and the second pipette tip discarding action. Let a, b, c, and d represent the first pipette tip acquisition action, the sample input action, the sample output action, and the first pipette tip discarding action in the sample distribution action, respectively; and let w, x, y, and z represent the second pipette tip acquisition action, the reagent input action, the reagent output action, and the second pipette tip discarding action in the reagent distribution action, respectively. Therefore, the time consumption of the sample / reagent distribution action is shown in Table 3.

[0176] Table 3: Time Consumption of Assigned Actions Table 1:

[0177]

[0178] Taking an eight-cup sample cup as an example, the sample and reagent allocation method provided in this embodiment will be explained. It is assumed that there are 8 samples to be tested (represented by A1 to A8 respectively), each sample to be tested is only tested once, and there are 2 types of test reagents (represented by R1 and R2 respectively). Each sample needs to be mixed with these two test reagents before it can be tested.

[0179] Based on this, this embodiment provides a first experimental example to illustrate in detail the sample and reagent dispensing method described in this application. Figure 6 This is a schematic diagram of the sample and reagent dispensing method provided in this experimental example.

[0180] like Figure 6 As shown, the sample and reagent dispensing method provided in this experimental example may include the following steps:

[0181] Step 1: Control the first element to move to the first nozzle acquisition area and perform the first nozzle acquisition action to acquire the nozzle, while pushing the eight cups to the sample distribution area.

[0182] Step 2: Control the first element to move to the sample acquisition area and perform the sample input action to acquire the sample A1 to be tested.

[0183] Step 3: Control the first element to move to the sample distribution area and execute the sample output action to distribute the sample A1 to be tested into the No. 1 reaction cup of the eight-cup.

[0184] Step 4: Control the first component to move to the first gun head discarding area and execute the first gun head discarding action to discard the gun head.

[0185] Step 5: Repeat steps 1 to 4 to complete the allocation of samples A2, A3, A4, and A5 to be tested, and allocate them to reaction cups No. 2, No. 3, No. 4, and No. 5 of the eight-cup system, respectively.

[0186] Step 6: Control the first element to perform the dispensing action of the sample A6 to be tested, and simultaneously start controlling the second element to perform the dispensing action of the test reagent R1, as follows. Figure 6 As shown, the sample input action for the sample to be tested A6 and the second nozzle acquisition action for the test reagent R1 are executed synchronously. Since the second element will only execute the reagent output action of the test reagent R1 after the first element performs the sample output action for the sample to be tested A6, both the dispensing action of the sample to be tested A6 executed by the first element and the dispensing action of the test reagent R1 executed by the second element are continuous actions.

[0187] Step 7: While the second element is dispensing the test reagent R1, the first element can complete the dispensing of the sample to be tested A6 and begin dispensing the sample to be tested A7. Since the first element performs the sample output action for the sample to be tested A7 while the second element is dispensing the test reagent R1, after the first element completes the first nozzle acquisition and sample input actions for the sample to be tested A7, the first element is paused and moved to avoid the sample dispensing area. After the second element completes the reagent output action for the test reagent R1 in the sample dispensing area, the first element is then moved back to the sample dispensing area to perform the sample output action for the sample to be tested A7.

[0188] Step 8: While the first element is performing the dispensing action of the sample A7 to be tested, the second element can complete the dispensing action of the test reagent R1 and start the dispensing action of the test reagent R2.

[0189] Step 9: While the second element is dispensing the test reagent R2, the first element can complete the dispensing of sample A7 and begin dispensing sample A8. Since the first element's sample output of sample A8 occurs during the second element's reagent output of test reagent R2, after the first element completes the first nozzle acquisition and sample input of sample A8, the first element is paused and moved out of the sample dispensing area. Once the second element completes the reagent output of test reagent R2 in the sample dispensing area, the first element is then moved back to the sample dispensing area to perform the sample output of sample A8.

[0190] In step 10, while the first element is dispensing the sample A8 to be tested, the second element can complete the dispensing of the test reagent R2. The first element is controlled to output the sample A8 to be tested, and while performing the first tip discarding action, the eight-cup is pushed to the sample incubation area.

[0191] As can be seen from the above steps, the sample and reagent detection method provided in this experimental example prioritizes the allocation of detection reagents. When the timing of the sample output action and the reagent output action overlaps at least partially, the first element will be controlled to stop the sample output action and move out of the sample allocation area. The second element will then be controlled to move to the sample allocation area and prioritize the execution of the reagent output action.

[0192] Combination Figure 6 Table 3 shows the sample and reagent distribution method provided in this experimental example. The total time required to complete the distribution of 8 samples to be tested and 2 types of test reagents is calculated as shown in Table 4.

[0193] Table 4. Sample / Reagent Distribution Time (Table 1)

[0194]

[0195] Since the sample allocation and reagent allocation actions are performed synchronously, while the first element is performing a sample allocation sub-action, the second element may be performing one, multiple, or a portion of a reagent allocation sub-action. Similarly, while the second element is performing a reagent allocation sub-action, the first element may be performing one, multiple, or a portion of a sample allocation sub-action. Therefore, "-" indicates the execution of multiple sub-actions, and "(1)" indicates the execution of a portion of a sub-action.

[0196] Since pushing the eight-cup sample dispenser to the sample dispensing area and to the sample incubation area are performed simultaneously with the sample dispensing action, the time spent pushing the eight-cup sample dispenser to the sample dispensing area and to the sample incubation area does not need to be added to the total sample / reagent dispensing time.

[0197] A comparison of Table 4 and Table 2 shows that the sample and reagent distribution method provided in this experimental example shortens the sample / reagent distribution time and improves the sample / reagent distribution efficiency. The comparison results are shown in Table 5.

[0198] Table 5 Comparison of Sample / Reagent Dispensing Time (Table 1)

[0199]

[0200] In the above experimental example, when the first element is controlled to perform the sample dispensing action for the sixth sample to be tested (A6), the second element is controlled to perform the reagent dispensing action for the first detection reagent (R1), but due to... Figure 6 It can also be seen that when the first element is controlled to perform the sample dispensing action on any sample to be tested, the second element is controlled to perform the reagent dispensing action on the test reagent. This can achieve partial overlap between the sample dispensing action and the reagent dispensing action, with only the degree of overlap differing. Therefore, the reagent dispensing action can be started synchronously with the dispensing action of any sample to be tested, and the specific form is not limited here.

[0201] In addition, the method shown in the above experimental examples is to simultaneously control the second element to perform the reagent dispensing action while controlling the first element to perform the sample input action in the sample dispensing action. Other synchronization situations will be explained below through different experimental examples.

[0202] This embodiment provides a second experimental example to illustrate the sample and reagent distribution method described in this application in detail. Figure 7 This is a schematic diagram of the sample and reagent dispensing method provided in this experimental example.

[0203] like Figure 7 As shown, the method provided in this experimental example is to simultaneously control the second element to perform the reagent dispensing action while controlling the first element to perform the first pipette tip acquisition action in the sample dispensing action. The specific method is as follows: Figure 7 As shown, no further details will be provided here.

[0204] Combination Figure 7 Table 3 shows the sample and reagent distribution method provided in this experimental example. The total time required to complete the distribution of 8 samples to be tested and 2 types of test reagents is calculated as shown in Table 6.

[0205] Table 6. Sample / Reagent Distribution Time (Table 2)

[0206]

[0207] A comparison of Table 6 and Table 2 shows that the sample and reagent distribution method provided in this experimental example shortens the sample / reagent distribution time and improves the sample / reagent distribution efficiency. The comparison results are shown in Table 7.

[0208] Table 7 Comparison of Sample / Reagent Distribution Time (Table 2)

[0209]

[0210]

[0211] This embodiment provides a third experimental example to illustrate the sample and reagent dispensing method described in this application in detail. Figure 8 This is a schematic diagram of the sample and reagent dispensing method provided in this experimental example.

[0212] like Figure 8 As shown, the method provided in this experimental example is to simultaneously control the second element to perform the reagent dispensing action while controlling the first element to perform the sample output action in the sample dispensing action. The specific method is as follows: Figure 8 As shown, no further details will be provided here.

[0213] Combination Figure 8 Table 3 shows the sample and reagent distribution method provided in this experimental example. The total time required to complete the distribution of 8 samples to be tested and 2 types of test reagents is calculated as shown in Table 8.

[0214] Table 8. Sample / Reagent Distribution Time (Table 3)

[0215]

[0216]

[0217] A comparison of Table 8 and Table 2 shows that the sample and reagent distribution method provided in this experimental example shortens the sample / reagent distribution time and improves the sample / reagent distribution efficiency. The comparison results are shown in Table 9.

[0218] Table 9 Comparison of Sample / Reagent Distribution Time (Table 3)

[0219]

[0220] This embodiment provides a fourth experimental example to illustrate the sample and reagent dispensing method described in this application in detail. Figure 9 This is a schematic diagram of the sample and reagent dispensing method provided in this experimental example.

[0221] like Figure 9 As shown, the method provided in this experimental example is to simultaneously control the second element to perform the reagent dispensing action while controlling the first element to perform the first pipette tip discarding action in the sample dispensing action. The specific method is as follows: Figure 9 As shown, no further details will be provided here.

[0222] Combination Figure 9 Table 3 shows the sample and reagent distribution method provided in this experimental example. The total time required to complete the distribution of 8 samples to be tested and 2 types of test reagents is calculated as shown in Table 10.

[0223] Table 10 Sample / Reagent Distribution Time Table 4

[0224]

[0225]

[0226] A comparison of Table 10 and Table 2 shows that the sample and reagent distribution method provided in this experimental example shortens the sample / reagent distribution time and improves the sample / reagent distribution efficiency. The comparison results are shown in Table 11.

[0227] Table 11 Comparison of Sample / Reagent Distribution Time (Table 4)

[0228]

[0229] In summary, simultaneously controlling the second element to perform the reagent dispensing action while controlling the first element to perform any sub-action of the sample dispensing action can achieve the goal of shortening the sample / reagent dispensing time and improving the sample / reagent dispensing efficiency.

[0230] The third embodiment of this application provides a method for distributing samples and reagents, and the method described in this application will be explained in detail through specific examples.

[0231] The sample dispensing action and reagent dispensing action have been described in detail in the first and second embodiments of this application, and the time consumption of each sub-action has been defined, so they will not be repeated here.

[0232] This embodiment provides a fifth experimental example to illustrate in detail the sample and reagent dispensing method described in this application. Figure 10 This is a schematic diagram of the sample and reagent dispensing method provided in this experimental example.

[0233] like Figure 10 As shown, the sample and reagent dispensing method provided in this experimental example may include the following steps:

[0234] Step 1: Control the first element to move to the first nozzle acquisition area and perform the first nozzle acquisition action to acquire the nozzle, while pushing the eight cups to the sample distribution area.

[0235] Step 2: Control the first element to move to the sample acquisition area and perform the sample input action to acquire the sample A1 to be tested.

[0236] Step 3: Control the first element to move to the sample distribution area and execute the sample output action to distribute the sample A1 to be tested into the No. 1 reaction cup of the eight-cup.

[0237] Step 4: Control the first component to move to the first gun head discarding area and execute the first gun head discarding action to discard the gun head.

[0238] Step 5: Repeat steps 1 to 4 to complete the allocation of samples A2 and A3 to be tested, and allocate samples A2 and A3 to reaction cups No. 2 and No. 3 of the eight-cup container, respectively.

[0239] Step 6: Control the first element to move to the first gun head acquisition area and execute the first gun head acquisition action to acquire the gun head; at the same time, control the second element to move to the second gun head acquisition area and execute the second gun head acquisition action to acquire the gun head.

[0240] Step 7: Synchronously control the first element to perform the sample dispensing action and the second element to perform the reagent dispensing action. Since the second element performs the reagent output action for the test reagent R1 during the process of the first element performing the sample output action for the sample to be tested A4, after controlling the second element to complete the second nozzle acquisition action and reagent input action for the test reagent R1, the second element is paused and moved to avoid the sample dispensing area. After the first element completes the sample output action for the sample to be tested A4 in the sample dispensing area, the second element is then controlled to move to the sample dispensing area to perform the reagent output action for the test reagent R1.

[0241] Step 8: While the second element is dispensing the test reagent R1, the first element completes the dispensing of sample A4 and begins dispensing sample A5. Since the first element's sample output of sample A5 occurs during the second element's sample output of test reagent R1, the second element is paused and moved out of the sample dispensing area. After the first element completes its sample output of sample A5 in the sample dispensing area, the second element is then moved back to the sample dispensing area to dispense test reagent R1.

[0242] In step 9, while the second element is dispensing the test reagent R1, the first element can complete the dispensing of the sample to be tested A5 and begin dispensing the sample to be tested A6. Since the time when the first element performs the sample output action for the sample to be tested A6 does not overlap with the time when the second element performs the reagent output action for the test reagent R1, no pause is required in this step.

[0243] In step 10, while the first element is performing the dispensing action of the sample A6 to be tested, the second element can complete the dispensing action of the test reagent R1 and begin to perform the dispensing action of the test reagent R2.

[0244] In step 11, while the second element is dispensing the test reagent R2, the first element can complete the dispensing of the sample to be tested A6 and begin dispensing the sample to be tested A7. Since the first element's sample output action for the sample to be tested A7 occurs during the second element's reagent output action for the test reagent R2, the second element is paused and moved out of the sample dispensing area. After the first element completes the sample output action for the sample to be tested A7 in the sample dispensing area, the second element is then moved to the sample dispensing area to perform the reagent output action for the test reagent R2.

[0245] In step 12, while the second element is controlling the dispensing action of the test reagent R2, the first element can complete the dispensing action of the sample to be tested A7 and start the dispensing action of the sample to be tested A8.

[0246] In step 13, while the first element is dispensing the sample A8 to be tested, the second element can complete the dispensing of the test reagent R2. The first element is controlled to output the sample A8 to be tested, and while performing the first tip discarding action, the eight-cup is pushed to the sample incubation area.

[0247] As can be seen from the above steps, the sample and reagent detection method provided in this experimental example prioritizes sample allocation. When the timing of the sample output action and the reagent output action at least partially overlaps, the second element is controlled to stop the reagent output action and move out of the sample allocation area. The first element is then controlled to move to the sample allocation area and execute the sample output action first.

[0248] Combination Figure 10 Table 3 shows the sample and reagent distribution method provided in this experimental example. The total time required to complete the distribution of 8 samples to be tested and 2 types of test reagents is calculated as shown in Table 12.

[0249] Table 12 Sample / Reagent Distribution Time Table 5

[0250]

[0251]

[0252] A comparison of Table 12 and Table 2 shows that the sample and reagent distribution method provided in this experimental example shortens the sample / reagent distribution time and improves the sample / reagent distribution efficiency. The comparison results are shown in Table 13.

[0253] Table 13 Comparison of Sample / Reagent Distribution Time (Table 5)

[0254]

[0255] In the above experimental example, while controlling the first element to perform the sample dispensing action for the fourth sample to be tested (A4), the second element is then controlled to perform the reagent dispensing action for the first detection reagent (R1), but due to... Figure 10 It can also be seen that when the first element is controlled to perform the sample dispensing action on any sample to be tested, the second element is controlled to perform the reagent dispensing action on the test reagent. This can achieve partial overlap between the sample dispensing action and the reagent dispensing action, with only the degree of overlap differing. Therefore, the reagent dispensing action can be started synchronously with the dispensing action of any sample to be tested, and the specific form is not limited here.

[0256] In addition, the method shown in the above experimental example is to simultaneously control the second element to perform the reagent dispensing action when the first element performs the first nozzle acquisition action in the sample dispensing action. Other synchronization situations will be explained below through different experimental examples.

[0257] This embodiment provides a sixth experimental example to illustrate the sample and reagent dispensing method described in this application in detail. Figure 11 This is a schematic diagram of the sample and reagent dispensing method provided in this experimental example.

[0258] like Figure 11As shown, the method provided in this experimental example is to simultaneously control the second element to perform the reagent dispensing action while controlling the first element to perform the sample input action in the sample dispensing action. The specific method is as follows: Figure 11 As shown, no further details will be provided here.

[0259] Combination Figure 11 Table 3 shows the sample and reagent distribution method provided in this experimental example. The total time required to complete the distribution of 8 samples to be tested and 2 types of test reagents is calculated as shown in Table 14.

[0260] Table 14 Sample / Reagent Distribution Time Table 6

[0261]

[0262]

[0263] A comparison of Table 14 and Table 2 shows that the sample and reagent distribution method provided in this experimental example shortens the sample / reagent distribution time and improves the sample / reagent distribution efficiency. The comparison results are shown in Table 15.

[0264] Table 15 Comparison of Sample / Reagent Distribution Time (Table 6)

[0265]

[0266] In summary, the sample and reagent allocation method provided in this embodiment prioritizes sample allocation. When the first element performs any sub-action of the sample allocation action, the second element is simultaneously controlled to perform the reagent allocation action, without changing the sample / reagent allocation time.

[0267] The second and third embodiments described above provide six experimental examples to illustrate the sample and reagent distribution method described in this application. It should be noted that the above embodiments are only for the purpose of understanding the method described in this application and are not intended to limit it.

[0268] The fourth embodiment of this application provides a sample analyzer. Figure 12 This is a schematic diagram of the sample analyzer provided in this embodiment.

[0269] like Figure 12 As shown, the sample analyzer provided in this embodiment includes: a sample dispensing unit 1201, a reagent dispensing unit 1202, and an incubation unit 1203.

[0270] The sample distribution unit 1201 is used to control the first element to perform a sample distribution action to distribute the sample to be tested into the reaction vessel. The sample distribution action includes at least a sample input action and a sample output action.

[0271] Optionally, the first element performs the sample allocation action once by allocating one sample to be tested into one of the reaction vessels. Within a testing batch, the number of times the first element performs the sample allocation action is the same as the number of samples to be tested.

[0272] The reagent dispensing unit 1202 is used to control the second element to perform a reagent dispensing action during the process of the sample dispensing unit controlling the first element to perform the sample dispensing action, dispensing the detection reagent into the reaction container. The reagent dispensing action includes at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are executed asynchronously.

[0273] Optionally, the second element performs the reagent dispensing action once by dispensing one test reagent into multiple reaction vessels. Within a test batch, the number of times the second element performs the reagent dispensing action is the same as the number of test reagents.

[0274] Optionally, before the step of controlling the second element to perform the reagent dispensing action during the process of controlling the first element to perform the sample dispensing action, the device is further configured to:

[0275] Based on the detection items, a detection mode is determined. The detection model includes a normal mode and a rapid mode. In the rapid mode, the execution time of the first element performing the sample output action and the execution time of the second element performing the reagent output action overlap at least partially.

[0276] Based on the detection mode, the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action are determined, wherein the execution mode includes a continuous execution mode and an intermittent execution mode.

[0277] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode includes:

[0278] If the detection mode is normal mode, the first element performs the sample dispensing action in a continuous manner, and the second element performs the reagent dispensing action in a continuous manner.

[0279] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode further includes:

[0280] If the detection mode is a fast mode, the first element performs the sample dispensing action intermittently, and the second element performs the reagent dispensing action continuously.

[0281] Optionally, during the process of controlling the first element to perform the sample dispensing action, controlling the second element to perform the reagent dispensing action includes:

[0282] During the overlap time, the first element is controlled to pause the sample output action, and the second element is controlled to perform the reagent output action;

[0283] After the second element completes the reagent output action, it controls the first element to perform the sample output action.

[0284] Optionally, the first element is a sample dispensing element with a configurable disposable nozzle, and the sample dispensing action further includes: a first nozzle acquisition action and a first nozzle disposal action; the first element performs the sample dispensing action intermittently, including:

[0285] Before the overlap time, the first element moves to the gun head acquisition area and acquires the first gun head to complete the first gun head acquisition action;

[0286] During the overlap time, the first element that has acquired the first gun head moves to the sample acquisition area and uses the first gun head to pick up a preset volume of the sample to be tested, thereby completing the sample input action.

[0287] After the overlap time, the first element that has been input with the sample to be tested moves to the sample distribution area and distributes the sample to be tested into the reaction vessel to complete the sample output action;

[0288] After the sample output action is completed, the first element of the sample to be tested that has been output is moved to the nozzle discarding area and the first nozzle is discarded to complete the first nozzle discarding action.

[0289] The overlap time is the time corresponding to the second element performing the reagent output action.

[0290] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode further includes:

[0291] If the detection mode is a fast model, the first element performs the sample dispensing action continuously, and the second element performs the reagent dispensing action intermittently.

[0292] Optionally, during the process of controlling the first element to perform the sample dispensing action, controlling the second element to perform the reagent dispensing action includes:

[0293] During the overlap time, the second element is controlled to pause the reagent output action, and the first element is controlled to perform the sample output action;

[0294] After the first element completes the sample output action, the second element is controlled to perform the reagent output action.

[0295] Optionally, the second element is a reagent dispensing element with a configurable disposable pipette tip. The reagent dispensing action further includes: a second pipette tip acquisition action and a second pipette tip disposal action; the second element performs the reagent dispensing action intermittently, including:

[0296] Before the overlap time, the second element moves to the gun head acquisition area to acquire the second gun head, thereby completing the second gun head acquisition action;

[0297] After the second nozzle acquisition action is completed, the second element that has acquired the second nozzle moves to the reagent acquisition area and draws a preset volume of the detection reagent through the second nozzle to complete the reagent input action;

[0298] After the reagent input action is completed, the second element with the input test reagent moves to the sample dispensing area and dispenses a portion of the test reagent into the reaction container to complete the first sub-action of the reagent output action;

[0299] During the overlap time, the second element that has already partially output the detection reagent moves out of the sample dispensing area and enters a waiting state;

[0300] After the overlap time, the second element that has already output a portion of the detection reagent moves to the sample dispensing area and dispenses the remaining portion of the detection reagent into the reaction vessel to complete the second sub-action of the reagent output action;

[0301] After completing the second sub-action of the reagent output action, the second element that has output the test reagent moves to the nozzle discarding area and discards the second nozzle to complete the second nozzle discarding action;

[0302] The overlap time is the time corresponding to the first element performing the sample output action.

[0303] The incubation unit 1203 is used to place the reaction container. The reaction container is fixed in the incubation unit during the distribution period of the sample to be tested and the test reagent. The sample distribution unit distributes the sample to be tested into multiple reaction containers by moving in the incubation unit. The reagent distribution unit distributes the test reagent into multiple reaction containers by moving in the incubation unit.

[0304] The fifth embodiment of this application provides an electronic device. Figure 13 This is a schematic diagram of the structure of the electronic device provided in this embodiment.

[0305] like Figure 13 As shown, the electronic device provided in this embodiment includes: a storage module 1301 and an execution module 1302.

[0306] The storage module 1301 is used to store computer instructions for executing sample and reagent dispensing methods.

[0307] The execution module 1302 is used to execute computer instructions stored in the storage module 1301 to perform the following operations:

[0308] The first element is controlled to perform a sample dispensing action, dispensing the sample to be tested into the reaction vessel. The sample dispensing action includes at least a sample input action and a sample output action.

[0309] During the process of controlling the first element to perform the sample dispensing action, the second element is controlled to perform the reagent dispensing action, dispensing the detection reagent into the reaction vessel. The reagent dispensing action includes at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are executed asynchronously.

[0310] Optionally, the first element performs the sample allocation action once by allocating one sample to be tested into one of the reaction vessels. Within a testing batch, the number of times the first element performs the sample allocation action is the same as the number of samples to be tested.

[0311] Optionally, the second element performs the reagent dispensing action once by dispensing one test reagent into multiple reaction vessels. Within a test batch, the number of times the second element performs the reagent dispensing action is the same as the number of test reagents.

[0312] Optionally, before the step of controlling the second element to perform the reagent dispensing action during the process of controlling the first element to perform the sample dispensing action, the method further includes:

[0313] Based on the detection items, a detection mode is determined. The detection model includes a normal mode and a rapid mode. In the rapid mode, the execution time of the first element performing the sample output action and the execution time of the second element performing the reagent output action overlap at least partially.

[0314] Based on the detection mode, the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action are determined, wherein the execution mode includes a continuous execution mode and an intermittent execution mode.

[0315] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode includes:

[0316] If the detection mode is normal mode, the first element performs the sample dispensing action in a continuous manner, and the second element performs the reagent dispensing action in a continuous manner.

[0317] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode further includes:

[0318] If the detection mode is a fast mode, the first element performs the sample dispensing action intermittently, and the second element performs the reagent dispensing action continuously.

[0319] Optionally, during the process of controlling the first element to perform the sample dispensing action, controlling the second element to perform the reagent dispensing action includes:

[0320] During the overlap time, the first element is controlled to pause the sample output action, and the second element is controlled to perform the reagent output action;

[0321] After the second element completes the reagent output action, it controls the first element to perform the sample output action.

[0322] Optionally, the first element is a sample dispensing element with a configurable disposable nozzle, and the sample dispensing action further includes: a first nozzle acquisition action and a first nozzle disposal action; the first element performs the sample dispensing action intermittently, including:

[0323] Before the overlap time, the first element moves to the gun head acquisition area and acquires the first gun head to complete the first gun head acquisition action;

[0324] During the overlap time, the first element that has acquired the first gun head moves to the sample acquisition area and uses the first gun head to pick up a preset volume of the sample to be tested, thereby completing the sample input action.

[0325] After the overlap time, the first element that has been input with the sample to be tested moves to the sample distribution area and distributes the sample to be tested into the reaction vessel to complete the sample output action;

[0326] After the sample output action is completed, the first element of the sample to be tested that has been output is moved to the nozzle discarding area and the first nozzle is discarded to complete the first nozzle discarding action.

[0327] The overlap time is the time corresponding to the second element performing the reagent output action.

[0328] Optionally, determining the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action according to the detection mode further includes:

[0329] If the detection mode is a fast model, the first element performs the sample dispensing action continuously, and the second element performs the reagent dispensing action intermittently.

[0330] Optionally, during the process of controlling the first element to perform the sample dispensing action, controlling the second element to perform the reagent dispensing action includes:

[0331] During the overlap time, the second element is controlled to pause the reagent output action, and the first element is controlled to perform the sample output action;

[0332] After the first element completes the sample output action, the second element is controlled to perform the reagent output action.

[0333] Optionally, the second element is a reagent dispensing element with a configurable disposable pipette tip. The reagent dispensing action further includes: a second pipette tip acquisition action and a second pipette tip disposal action; the second element performs the reagent dispensing action intermittently, including:

[0334] Before the overlap time, the second element moves to the gun head acquisition area to acquire the second gun head, thereby completing the second gun head acquisition action;

[0335] After the second nozzle acquisition action is completed, the second element that has acquired the second nozzle moves to the reagent acquisition area and draws a preset volume of the detection reagent through the second nozzle to complete the reagent input action;

[0336] After the reagent input action is completed, the second element with the input test reagent moves to the sample dispensing area and dispenses a portion of the test reagent into the reaction container to complete the first sub-action of the reagent output action;

[0337] During the overlap time, the second element that has already partially output the detection reagent moves out of the sample dispensing area and enters a waiting state;

[0338] After the overlap time, the second element that has already output a portion of the detection reagent moves to the sample dispensing area and dispenses the remaining portion of the detection reagent into the reaction vessel to complete the second sub-action of the reagent output action;

[0339] After completing the second sub-action of the reagent output action, the second element that has output the test reagent moves to the nozzle discarding area and discards the second nozzle to complete the second nozzle discarding action;

[0340] The overlap time is the time corresponding to the first element performing the sample output action.

[0341] It should be noted that the relational terms such as "first" and "second" used in this document are only used to distinguish one entity or operation from another, and do not require or imply any actual relationship or order between these entities or operations. Furthermore, "including," "having," "containing," and other similar terms are synonymous, and the conclusion of any one or more items following any of the foregoing words is open-ended; none of the foregoing terms indicates that the one or more items have been exhaustively listed, or are limited to only one or more of the listed items.

[0342] When used herein, unless otherwise expressly stated, the term "or" includes all possible combinations except those that are impractical. For example, if expressed as a database may include A or B, then unless otherwise specified or impractical, it may include database A, or B, or A and B. As a second example, if expressed as a database may include A, B, or C, then unless otherwise specified or impractical, the database may include database A, or B, or C, or A and B, or A and C, or B and C, or A and B and C.

[0343] It is worth noting that the above embodiments can be implemented by hardware or software (program code), or a combination of hardware and software. If implemented by software, it can be stored in the above-described computer-readable medium. When executed by a processor, the software can perform the methods disclosed above. The computing units and other functional units described in this disclosure can be implemented by hardware or software, or a combination of hardware and software. Those skilled in the art will also understand that the above-described multiple modules / units can be combined into one module / unit, and each of the above-described modules / units can be further divided into multiple sub-modules / sub-units.

[0344] In the foregoing detailed description, embodiments have been described with reference to numerous specific details, which may vary depending on the implementation. Certain adaptations and modifications can be made to the embodiments. Other implementations will be readily apparent to those skilled in the art from the specific embodiments disclosed herein. This specification and examples are for illustrative purposes only, and the true scope and essence of this application are defined by the claims. The sequence of steps shown in the figures is also for illustrative purposes only and is not intended to limit to any particular step or order. Therefore, those skilled in the art will recognize that these steps can be performed in different orders when implementing the same method.

[0345] Exemplary embodiments are disclosed in the figures and detailed description of this application. However, many variations and modifications can be made to these embodiments. Accordingly, although specific terms are used, they are only general and descriptive and not for limiting purposes.

Claims

1. A method for dispensing samples and reagents, characterized in that, The method is applied to a detection device that dispenses a sample to be tested and a detection reagent into a reaction vessel in the same dispensing area, wherein the reaction vessel is fixed in the dispensing area during the dispensing period of the sample to be tested and the detection reagent, and the method includes: The first element is controlled to perform a sample dispensing action, dispensing the sample to be tested into the reaction vessel. The sample dispensing action includes at least a sample input action and a sample output action. During the process of controlling the first element to perform the sample dispensing action, the second element is controlled to perform a reagent dispensing action, dispensing the detection reagent into the reaction vessel. The reagent dispensing action includes at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are performed asynchronously; wherein, prior to the step of controlling the second element to perform the reagent dispensing action during the process of controlling the first element to perform the sample dispensing action, the method further includes: Based on the detection items, a detection mode is determined, which includes a normal mode and a rapid mode. In the rapid mode, the execution time of the first element performing the sample output action and the execution time of the second element performing the reagent output action overlap at least partially. Based on the detection mode, the execution mode of the first element performing the sample dispensing action and the execution mode of the second element performing the reagent dispensing action are determined, wherein the execution mode includes a continuous execution mode and an intermittent execution mode.

2. The method according to claim 1, characterized in that, The first element performs the sample allocation action once by allocating one sample to be tested into one of the reaction vessels. Within a test batch, the first element performs the sample allocation action the same number of times as the number of samples to be tested.

3. The method according to claim 1, characterized in that, The second element performs the reagent dispensing action once by dispensing one test reagent into multiple reaction vessels. Within a test batch, the second element performs the reagent dispensing action the same number of times as the number of test reagents.

4. The method according to claim 1, characterized in that, The step of determining the execution mode of the sample dispensing action performed by the first element and the execution mode of the reagent dispensing action performed by the second element according to the detection mode includes: If the detection mode is normal mode, the first element performs the sample dispensing action in a continuous manner, and the second element performs the reagent dispensing action in a continuous manner.

5. The method according to claim 1, characterized in that, The step of determining the execution mode of the sample dispensing action performed by the first element and the execution mode of the reagent dispensing action performed by the second element according to the detection mode further includes: If the detection mode is a fast mode, the first element performs the sample dispensing action intermittently, and the second element performs the reagent dispensing action continuously.

6. The method according to claim 5, characterized in that, The step of controlling the second element to perform a reagent dispensing action during the process of controlling the first element to perform the sample dispensing action includes: During the overlap time, the first element is controlled to pause the sample output action, and the second element is controlled to perform the reagent output action; After the second element completes the reagent output action, it controls the first element to perform the sample output action.

7. The method according to claim 6, characterized in that, The first element is a sample dispensing element with a configurable disposable nozzle. The sample dispensing action further includes: a first nozzle acquisition action and a first nozzle disposal action; the first element performs the sample dispensing action intermittently, including: Before the overlap time, the first element moves to the gun head acquisition area and acquires the first gun head to complete the first gun head acquisition action; During the overlap time, the first element that has acquired the first gun head moves to the sample acquisition area and uses the first gun head to pick up a preset volume of the sample to be tested, thereby completing the sample input action. After the overlap time, the first element that has been input with the sample to be tested moves to the sample distribution area and distributes the sample to be tested into the reaction vessel to complete the sample output action; After the sample output action is completed, the first element of the sample to be tested that has been output is moved to the nozzle discarding area and the first nozzle is discarded to complete the first nozzle discarding action. The overlap time is the time corresponding to the second element performing the reagent output action.

8. The method according to claim 1, characterized in that, The step of determining the execution mode of the sample dispensing action performed by the first element and the execution mode of the reagent dispensing action performed by the second element according to the detection mode further includes: If the detection mode is a fast model, the first element performs the sample dispensing action continuously, and the second element performs the reagent dispensing action intermittently.

9. The method according to claim 8, characterized in that, The step of controlling the second element to perform a reagent dispensing action during the process of controlling the first element to perform the sample dispensing action includes: During the overlap time, the second element is controlled to pause the reagent output action, and the first element is controlled to perform the sample output action; After the first element completes the sample output action, the second element is controlled to perform the reagent output action.

10. The method according to claim 9, characterized in that, The second element is a reagent dispensing element with a configurable disposable pipette tip. The reagent dispensing action further includes: a second pipette tip acquisition action and a second pipette tip disposal action; the second element performs the reagent dispensing action intermittently, including: Before the overlap time, the second element moves to the gun head acquisition area to acquire the second gun head, thereby completing the second gun head acquisition action; After the second nozzle acquisition action is completed, the second element that has acquired the second nozzle moves to the reagent acquisition area and draws a preset volume of the detection reagent through the second nozzle to complete the reagent input action; After the reagent input action is completed, the second element with the input test reagent moves to the sample dispensing area and dispenses a portion of the test reagent into the reaction container to complete the first sub-action of the reagent output action; During the overlap time, the second element that has already partially output the detection reagent moves out of the sample dispensing area and enters a waiting state; After the overlap time, the second element that has already output a portion of the detection reagent moves to the sample dispensing area and dispenses the remaining portion of the detection reagent into the reaction vessel to complete the second sub-action of the reagent output action; After completing the second sub-action of the reagent output action, the second element that has output the test reagent moves to the nozzle discarding area and discards the second nozzle to complete the second nozzle discarding action; The overlap time is the time corresponding to the first element performing the sample output action.

11. A sample analyzer, characterized in that, The sample analyzer includes at least: a sample dispensing unit, a reagent dispensing unit, and an incubation unit; The sample dispensing unit is used to control the first element to perform a sample dispensing action to dispense the sample to be tested into the reaction vessel. The sample dispensing action includes at least a sample input action and a sample output action. The reagent dispensing unit is configured to control a second element to perform a reagent dispensing action during the process of the sample dispensing unit controlling the first element to perform the sample dispensing action, dispensing the detection reagent into the reaction container. The reagent dispensing action includes at least a reagent input action and a reagent output action; wherein the sample output action and the reagent output action are mutually exclusive. Prior to the step of controlling the second element to perform the reagent dispensing action during the process of controlling the first element to perform the sample dispensing action, the unit is further configured to: determine a detection mode based on the detection item, the detection mode including a normal mode and a fast mode, wherein in the fast mode, the execution time of the first element performing the sample output action and the execution time of the second element performing the reagent output action at least partially overlap; and determine the execution method of the first element performing the sample dispensing action and the execution method of the second element performing the reagent dispensing action based on the detection mode, wherein the execution method includes a continuous execution method and an intermittent execution method. The incubation unit is used to place the reaction container. The reaction container is fixed in the incubation unit during the distribution period of the sample to be tested and the test reagent. The sample distribution unit distributes multiple samples to be tested into multiple reaction containers by moving in the incubation unit. The reagent distribution unit distributes the test reagent into the multiple reaction containers by moving in the incubation unit.

12. An electronic device, characterized in that, include: Storage module, execution module; The storage module is used to store one or more computer instructions; The execution module is used to execute one or more computer instructions to implement the method as described in any one of claims 1-10.

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