A herbicide compound for controlling Canada goldenrod and its application

Abstract

The present invention relates to a herbicide compound and its use. The active ingredients of the herbicide compound are saflufenacil and fluazifop-butyl, with a mass ratio of 1:5 to 5:1. The herbicide compound exhibits significant synergistic control effects against Canada goldenrod within the aforementioned ratio range. The technical solution of the present invention can reduce pesticide usage, reduce the number of applications, lower costs, and mitigate adverse impacts on the ecological environment. A single application of the compound solves the problem of difficult control of the invasive species, Canada goldenrod; and the compound's service life is extended, which is of great significance for the comprehensive control of invasive weeds.

Description

Technical Field

[0001] The present invention belongs to the technical field of pesticides, and in particular relates to a pesticide complex containing saflufenacil and fluazifop-butyl for controlling Canada goldenseal and an application thereof. Background Art

[0002] Canada goldenrod, also known as goldenrod, goldenrod, and goldenrod, is a perennial herb in the Asteraceae family. Introduced to my country as an ornamental plant in 1935, it subsequently escaped into the wild and spread rapidly in areas like Shanghai. Its well-developed underground rhizomes, rapid growth rate, and diverse reproductive methods give it a strong competitive advantage, posing a significant threat to native plants and easily forming monocultures, severely impacting biodiversity. In 2010, Canada goldenrod spread severely throughout southern my country, earning it the second tranche of the "List of Invasive Alien Species in China." A multi-site survey by the Farmland Weed Control Innovation Team at the Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, found that Canada goldenrod has severely damaged habitats such as ridges, roadsides, wastelands, woodlands, highway protection zones, river embankments, and rural residential areas in cities like Nanjing, Zhenjiang, Yangzhou, Taizhou, Huai'an, and Suqian in Jiangsu Province, posing a serious threat to the ecological environment and posing an urgent need for effective prevention and control.

[0003] At present, Canada goldenrod is mostly controlled through conventional methods such as manual or mechanical cutting and chemical control. Manual or mechanical cutting is generally carried out during the flowering period, and the above-ground stems of Canada goldenrod are cut; chemical control is generally carried out during the flowering and fruiting period, and chemical herbicides such as glyphosate and clofopyralid are manually sprayed to kill Canada goldenrod. Conventional control methods are basically ineffective against underground rhizomes. Canada goldenrod can quickly regenerate into new plants, causing secondary flooding damage, which only treats the symptoms and not the root cause, and is costly and has poor benefits. Therefore, it is particularly important to explore a safe, low-risk weed control combination that can effectively block the damage caused by Canada goldenrod throughout the year with a single chemical control.

[0004] Safensulfuron is a highly active, broad-spectrum, and low-risk protoporphyrinogen oxidase (PPO) inhibitor. It inhibits PPO in sensitive plants, increasing protoporphyrinogen levels in the cytosol and enhancing lipid peroxidation in cell membranes. This damages cell membrane structure and function, leading to cell leakage, tissue necrosis, and ultimately plant death. Safensulfuron exhibits foliar contact activity and soil residual activity. It is readily absorbed by leaves and roots, then transported through the apoplast and locally in the phloem, distributing throughout the plant. It is used to control over 100 broadleaf weed species, including Amaranthus pubescens, Glechoma longituba, Bidens pilosa, Chickweed, and Amaranthus retroflexus.

[0005] Flupyrifos-sodium is a new pyrimidine salicylate herbicide developed with bispyribac-sodium as its lead compound. Its mechanism of action is to inhibit the activity of plant acetolactate synthase (ALS), leading to a blockage in amino acid synthesis, affecting protein synthesis, and further inhibiting cell division, causing plant tissue to lose green and yellow, inhibiting plant growth, and ultimately killing the plant. Studies have shown that flupyrifos-sodium is effective against a variety of weeds, including barnyardgrass, duckweed, snakehead, and lilac, with the advantages of high activity and low ecological and environmental risks.

[0006] Canada goldenrod is an invasive weed that is difficult to control and has little control effect. In the existing technology, there is no effective method for controlling Canada goldenrod. Summary of the Invention

[0007] The invention aims to achieve high-efficiency and low-cost control of Canada goldenrod.

[0008] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is:

[0009] Provided is a herbicide complex consisting of saflufenacil and fluazifop-butyl, for controlling Canada goldenrod; during a specific growth period of Canada goldenrod, highly effective control can be achieved with only a single application; and the combination of the two has a significant synergistic effect in controlling Canada goldenrod.

[0010] In the herbicidal complex of saflufenacil and flupyfenac, the mass ratio of saflufenacil and flupyfenac is 1:10 to 10:1, preferably 1:5 to 5:1, more preferably 1:5, 1:2, 1:1, 2:1, 5:1, 3:4 or 4:5, particularly preferably 3:4 and 4:5.

[0011] The herbicidal compound is mixed with agriculturally acceptable adjuvants to prepare any formulation suitable for agricultural use. The formulation is preferably a dispersible oil suspension, suspension concentrate, aqueous emulsion, water-dispersible granule, etc., and the more preferred formulation is a suspension concentrate.

[0012] The mass percentage of the active ingredient in the preparation is 1-95%, preferably 1-80%.

[0013] When controlling Canada goldenrod, the herbicidal compound or a formulation containing the herbicidal compound is applied to the branches, leaves, roots, or growth environment of Canada goldenrod, and only one application of the drug is used during the growth period of Canada goldenrod to control the damage of Canada goldenrod throughout the year.

[0014] When applying the herbicidal mixture or preparation, it is selected to be applied during a specific growth period of Canada goldenrod, so as to achieve high-efficiency control with one application.

[0015] Compared with the prior art, the technical solution of the present invention has at least the following advantages:

[0016] 1) It has a significant synergistic effect: when the mass ratio of the active ingredients is 1:5 to 5:1, the herbicide complex of saflufenacil and fluazifop-butyl shows a synergistic effect on Canada thistle.

[0017] 2) Single-application, highly effective control: During the Canada thistle's growth period, a single application can control its damage year-round. Low cost, ease of use, and time and labor savings are key. It is particularly effective against Canada thistle's underground rhizomes, contributing to sustainable control of the disease and meeting current requirements for pesticide application reduction and increased efficiency, offering significant economic, social, and ecological benefits. Specific implementation plan

[0018] The present invention will be further described below with reference to specific embodiments. The following are merely preferred embodiments of the present invention and are intended only to illustrate the present invention and are not to be construed as limiting the scope of the present invention. It should be noted that any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention are intended to be included within the scope of protection of the present invention.

[0019] In the following examples, unless otherwise specified, all percentages are by weight.

[0020] Example 1: 20% saflufenacil·pyrimidine-butyl dispersible oil suspension

[0021] Safenacil 10%, fluazifop-butyl 10%, sodium lauryl sulfate 2%, naphthalenesulfonic acid formaldehyde condensate 2%, calcium lignin sulfonate 2%, modified hydrogenated castor oil 4%, agricultural milk 507# 4%, fumed silica 5%, methyl oleate to 100%.

[0022] The preparation method is as follows:

[0023] Additives (sodium lauryl sulfate, naphthalenesulfonic acid formic acid condensate and calcium ligninsulfonate, hydrogenated castor oil, and Nongru 507#) were added to methyl oleate and mixed uniformly. The technical product and fumed silica were added under stirring (2000 rpm) on a high-speed shear (FA25, Shanghai Fluke Fluid Machinery Manufacturing Co., Ltd.) and stirred for 20 minutes to mix uniformly. The materials were injected into a multi-stage sand mill (D05, Shanghai Rujia Electromechanical Technology Co., Ltd.) and ground until the particle size reached Dv98 ≤ 5 μm. The mixture was then stirred uniformly to prepare a 20% saflufenacil / pyrimidobutyl dispersible oil suspension concentrate.

[0024] Example 2: 40% saflufenacil·pyrimidine-butyl water dispersible granules

[0025] Safenacil 24%, fluazifop-butyl 16%, wetting agent EFW 2%, dispersant D425 7%, anhydrous sodium sulfate 20%, kaolin to 100%.

[0026] The preparation method is as follows:

[0027] According to the composition and quality requirements, each component was added to a universal grinder (ZSJB, Zhangjiagang Kaichuang Machinery Manufacturing Co., Ltd.) for pre-crushing. The mixture was then added to a jet mill (IM, Changzhou Lima Drying Technology Co., Ltd.) for jet grinding. The material after the airflow had a fineness of 98% passing 1-5 μm and was discharged. The wet material (water content 10-15%) was kneaded and granulated using a rotary extrusion granulator (ZLB1-80, Zhangjiagang Kaichuang Machinery Manufacturing Co., Ltd.). Finally, the wet material was dried using a boiling dryer (FG3, Jiangsu Pioneer Drying Engineering Co., Ltd.) to produce 40% saflufenacil·pyrimidine-butyl water-dispersible granules.

[0028] Example 3: 20% saflufenacil·pyrimidine-butyl dispersible oil suspension

[0029] Safenacil 14%, fluazifop-butyl 6%, T-80 3%, AEO-3 2%, EL-40 3%, Nongru 500# 8%, organic bentonite 2%, edible soybean oil supplemented to 100%,

[0030] The preparation method is as follows:

[0031] Additives (T80, AEO-3, Nongru 500#, EL-40) were added to edible soybean oil and mixed thoroughly. The technical product and organobentonite were added under shearing (2000 rpm) on a high-speed shearing machine (FA25, Shanghai Fluke Fluid Machinery Manufacturing Co., Ltd.) and stirred for 20 minutes to mix thoroughly. The material was injected into a multi-stage sand mill (D05, Shanghai Rujia Electromechanical Technology Co., Ltd.) and ground until the particle size reached Dv98 ≤ 5 μm. The mixture was stirred thoroughly to prepare a 20% saflufenacil / pyrimidinesulfuron dispersible oil suspension concentrate.

[0032] Example 4: 24% saflufenacil·pyrimidine-butyl suspension concentrate

[0033] Safenacil 20%, fluazifop-butyl 4%, tristyrylphenol polyoxyethylene ether sulfate (FD) 2%, polycarboxylate (788) 2%, phosphate (1015) 2%, ethylene glycol 5%, magnesium aluminum silicate 2%, defoamer 0.5%, preservative 0.1%, xanthan gum 0.1%, water to 100%.

[0034] The preparation method is as follows:

[0035] Accurately measured amounts of 1015, 788, FD, ethylene glycol, magnesium aluminum silicate, and a defoamer were added to water and mixed thoroughly. The technical product was added under shearing conditions (2000 rpm) using a high-speed shearing machine (FA25, Shanghai Fluke Fluid Machinery Manufacturing Co., Ltd.) and stirred for 20 minutes to mix thoroughly. The material was then injected into a multi-stage sand mill (D05, Shanghai Rujia Electromechanical Technology Co., Ltd.) and ground until the particle size reached Dv98 ≤ 5 μm. The mixture was then stirred thoroughly to prepare a 20% saflufenacil / pyrifos-butyl dispersible oil suspension concentrate.

[0036] 24% saflufenacil·pyrimidine-butyl suspension concentrate can be prepared.

[0037] Example 5: 24% saflufenacil·pyrimidine-butyl suspension concentrate

[0038] Safenacil 16%, fluazifop-butyl 8%, and the rest are the same as in Example 4.

[0039] Example 6: Screening of the optimal ratio of saflufenacil and fluazifop-butyl

[0040] In order to explore the combined effects of saflufenacil and flupyfenacil on weeds and their safety to crops, indoor bioassays were conducted to screen the formulations of saflufenacil and flupyfenacil mixtures.

[0041] Experimental weeds: Canada goldenrod (Solidago canadensis L.). In June 2022, seedlings about 20 cm high were dug out with roots from the ditch embankment next to the experimental field of Jiangsu Academy of Agricultural Sciences and transplanted into pots (30 cm in diameter and 60 cm in height) for cultivation.

[0042] Test instruments: PWT-510 spray tower, Mettler AB135-S electronic balance, volumetric flask, Erlenmeyer flask, beaker, measuring cylinder, plastic bowl, pipette, ruler, scissors, etc.

[0043] Preparation of stock solution: Weigh a certain amount of saflufenacil and fluazifop-butyl technical, dissolve thoroughly in acetone, and dilute with 0.1% Tween 80 aqueous solution to prepare a single-dose stock solution. Prepare a blank control by adding an equal amount of acetone to an equal amount of 0.1% Tween 80 aqueous solution.

[0044] Test method: 15 days after transplanting and cultivation, when the Canada goldenrod plant height was about 20 cm, soil spraying was performed using a PWT-510 spray tower with a liquid volume of 30 L / 667 m 2 After treatment, the plants were placed in the net room of Jiangsu Academy of Agricultural Sciences for cultivation, and water was added regularly to keep the soil moist.

[0045] Survey Method: Regularly observe weed growth after application. 30 and 90 days after application, measure the aboveground fresh weight and calculate the fresh weight inhibition rate, which represents the control effect on Canada goldenrod. The Gowing method was used to evaluate the combined effect of two mixed agents, using the following formula:

[0046] E0(%)=X+Y(100-X) / 100

[0047] Where X is the fresh weight inhibition rate of saflufenacil on Solidago canadensis at that dose, and Y is the fresh weight inhibition rate of flupyralid on Solidago canadensis at that dose. E0 is the theoretical fresh weight inhibition rate of the two active ingredients mixed against Solidago canadensis, i.e., the theoretical control efficacy.

[0048] When E(measured protective efficacy)-E0>10%, it is a synergistic effect; when E(measured protective efficacy)-E0<-10%, it is an antagonistic effect; when the E(measured protective efficacy)-E0 value is between -10% and 10%, it is an additive effect.

[0049] Test results: 30 days after application, saflufenacil and flupyralid combined showed high control efficacy against the fresh weight of the aboveground parts of Solidago canadensis, demonstrating a significant synergistic effect between the two ingredients. The combined action coefficients of saflufenacil and flupyralid were greater than 10 at ratios of 1:5 to 5:1, with the most pronounced synergistic effects observed at ratios of 3:4 and 4:5, with combined coefficients exceeding 15 (Table 1).

[0050] Table 1 Control effect of saflufenacil-pyrifos-sodium mixture on Solidago canadensis - 30 days after application

[0051]

[0052]

[0053] At 90 days after application, the control effect of saflufenacil and flupyralid on the aboveground fresh weight of Solidago canadensis was slightly lower than at 30 days, but the two components still had a significant synergistic effect. The combined action coefficients of saflufenacil and flupyralid were greater than 10 at ratios of 1:5 to 5:1, with the most significant synergistic effects at ratios of 3:4 and 4:5, with combined action coefficients exceeding 15 (Table 2).

[0054] Table 2 The efficacy of saflufenacil-pyrifos mixture on the control of Solidago canadensis - 90 days after application

[0055]

[0056] Example 7 Field efficacy test

[0057] Test agent: Select the mixed herbicide prepared in Examples 1 to 5.

[0058] Control agent: 70% saflufenacil water dispersible granules (commercially available)

[0059] 10% fluazifop-butyl SC (commercially available)

[0060] Set up clear water control

[0061] Usage: In the early stage of vigorous growth of Canada goldenrod (i.e. when the plant height is 0.8-1.0m), the amount of liquid medicine is 40 liters per mu.

[0062] Application time: May 25, 2023.

[0063] Survey subjects and methods: Canada thistle; On June 24 (30 days after application) and October 21 (150 days after application), the fresh weight of the aboveground parts of Canada thistle was investigated.

[0064] The test results are shown in Table 3.

[0065] Table 3 Field efficacy test results - 30 and 150 days after application

[0066]

[0067] As can be seen from Table 3, in the field efficacy tests, the herbicide compositions prepared in Examples 1-5 were significantly more effective than the control composition in controlling the fresh weight of the aboveground parts of Solidago canadensis. The herbicide compositions prepared in Examples 1-5 exhibited a significant synergistic effect against Solidago canadensis, significantly outperforming a single agent. They possessed the advantages of high efficacy, long-lasting effectiveness, and effective year-round control with a single application.

[0068] In addition, the researchers also conducted field control trials on plants in the seedling growth stage (i.e., when the plant height is approximately 30-50 cm) and in the middle and late stages of vigorous growth (i.e., when the plant height is greater than 1.2 m). The test results showed that when the control was carried out during the seedling growth stage (i.e., when the plant height is approximately 30-50 cm), the control effect 30 days after application was basically equivalent to that of Example 7. The highest control effect of Examples 1-5 all reached 100% control. However, at 150 days after application, as the plants entered the vigorous growth stage and the drug's long-lasting effect decreased, the control effect dropped significantly. The highest control effect 150 days after application was only about 38.56%, which clearly did not meet the control requirements. When the control was carried out during the middle and late stages of vigorous growth (i.e., when the plant height is greater than 1.2 m), the control effect was poor at both 30 and 150 days after application. The highest control effect 30 days after application was only about 26.65%, which was achieved in Example 1, and the highest control effect 150 days after application was only about 20.37%, which was achieved in Example 1. None of them can meet the control needs.

[0069] By comparing the effectiveness of pesticide application at different times, researchers determined that the optimal application period is during the early, vigorous growth phase of Canada goldenrod, when the plant is 0.8 to 1.0 meters tall. During this period, the plant is in its peak growth phase, with rapid cell proliferation and a high demand for external nutrients and other substances. Applying the pesticide at this time maximizes its utilization, inhibiting the plant's normal growth and disrupting its normal growth cycle, resulting in optimal control. A single application during its growth period can achieve long-term control.

Claims

1. A herbicide compound for controlling Canada goldenrod, characterized in that: The active ingredients of the herbicidal compound are saflufenacil and fluazifop-butyl, and the mass ratio of the two is within the range of 1:5-5:

1.

2. The herbicidal compound according to claim 1, characterized in that The mass ratio of benzylpyrifos and fluazifop-butyl is 1:5, 1:2, 1:1, 2:1, 5:1, 3:4 or 4:

5.

3. A herbicide for controlling Canada goldenrod, characterized in that: The herbicide comprises the herbicidal compound according to any one of claims 1 to 2 and an agriculturally acceptable adjuvant, and is prepared into a formulation suitable for agricultural use, wherein the formulation is a dispersible oil suspension, suspension concentrate, aqueous emulsion or water-dispersible granules.

4. The herbicide according to claim 3, characterized in that The weight percentage of the active ingredient in the preparation is 1-95%.

5. The herbicide according to claim 3, characterized in that The weight percentage of the active ingredient in the preparation is 1-80%.

6. The herbicide according to claim 3, characterized in that The preparation is a suspension.

7. Use of the herbicidal compound according to any one of claims 1 to 2 or the herbicide according to any one of claims 3 to 6 for controlling Solidago canadensis, characterized in that: When controlling Canada goldenrod, apply the medicine during the initial stage of vigorous growth of Canada goldenrod when the plant height is 0.8-1.0m. Only one application of the medicine is needed to control the damage caused by Canada goldenrod throughout the year.

8. A method for controlling Canada goldenrod, characterized in that: The method comprises applying the herbicidal compound according to any one of claims 1 to 2 or the herbicide according to any one of claims 3 to 6 in the early stage of vigorous growth of Canada goldenrod when the plant height is 0.8 to 1.0 m, and applying the drug only once during the entire growth period of Canada goldenrod.

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