A herbicidal composition containing dichloroisoniximone and pyroxasulfone and use thereof

Abstract

This invention relates to the field of pesticide technology, specifically to a herbicidal composition containing dichloroisoxane and sulfadiazine and its application in controlling agricultural weeds, wherein the weight ratio of dichloroisoxane to sulfadiazine in the composition is 1:0.007-1.4. The composition can significantly reduce herbicide damage to crops and has a synergistic effect on weeds, making it an ideal herbicide.

Description

Technical Field

[0001] This invention relates to the field of pesticide technology, specifically to a herbicidal composition containing dichloroisoxane and pyrazosulfuron and its application in controlling agricultural weeds. Background Technology

[0002] Wheat is my country's third largest grain crop after corn and rice, accounting for more than 20% of the country's total grain output. Therefore, ensuring a sustained bumper wheat harvest is of great significance for maintaining my country's grain self-sufficiency rate and safeguarding national food security. However, wheat production faces numerous threats, with weeds being one of the most significant. Weed infestations cover more than 90% of wheat fields in my country, resulting in yield losses of up to 15%. Simultaneously, with the continuous increase in labor costs in my country, the use of herbicides to control weed damage in wheat fields has become a necessary measure for wheat production. However, with the passage of time, weeds such as *Alopecurus aequalis*, *Brassica rapa*, *Capsella bursa-pastoris*, and *Desmodium styracifolium* have developed significant resistance to traditional herbicides, leading to a marked reduction in control effectiveness.

[0003] Dichloroisoxane is a novel isoxazoline ketone herbicide that can be absorbed by the roots and shoots of weeds and translocated upwards to various parts of the plant via transpiration. It inhibits 1-deoxy-D-xylinosyl-5-phosphate synthase, blocking carotenoid synthesis, leading to leaf whitening, inability to photosynthesize, and death. It can be used to control various grassy and broadleaf weeds in wheat, corn, cotton, and other crop fields. In wheat fields, dichloroisoxane is effective against a variety of weeds, including shepherd's purse, shepherd's purse, chickweed, common chickweed, speedwell, wild oats, large-spike wild oats, Japanese wild oats, and ryegrass. Especially due to its novel mechanism of action, it is also effective against resistant weeds, playing an important role in the management of resistant weeds in wheat fields. However, dichloroisoxane has poor safety in wheat and is prone to phytotoxicity under low-temperature conditions. Therefore, improving the safety of dichlorvos for wheat, reducing the risk of phytotoxicity, and fully utilizing the effects of this novel herbicide mechanism are of great significance for weed control in wheat fields. Summary of the Invention

[0004] During the experiment, the applicant discovered that the phytotoxicity of wheat caused by dichloroisoxane when mixed with the herbicide acetamiprid was significantly less than that caused by dichloroisoxane alone. Based on this, the present invention provides a herbicidal composition and formulation that can significantly reduce the phytotoxicity of dichloroisoxane to wheat, for controlling weeds in wheat fields, reducing the risk of herbicide damage, and improving control efficacy.

[0005] One aspect of the present invention relates to a herbicidal composition containing dichloroisoxane and pyrazosulfuron, wherein the weight ratio of dichloroisoxane to pyrazosulfuron is 1:0.007-1.4.

[0006] Preferably, the weight ratio of dichloroisoxane to pyrazosulfuron is 1:0.01-0.2.

[0007] More preferably, the weight ratio of dichloroisoxane to pyrazosulfuron is 1:0.02-0.15.

[0008] Another aspect of the present invention relates to a herbicide containing the above-described dichloroisoxane and pyrazosulfuron-methyl herbicidal composition.

[0009] In the herbicide of the present invention, dichloroisoxane and pyrazosulfuron account for 5% to 90% of the total weight, preferably 20% to 60%, and more preferably 25% to 40%.

[0010] The herbicide of the present invention can be added with agriculturally acceptable adjuvants and / or carriers, and can be processed into any pesticide-acceptable formulation as needed, such as wettable powder, suspension concentrate, water-dispersible granules, suspension emulsion, microemulsion, water-in-oil emulsion, emulsifiable concentrate, oil suspension, soluble powder, dry suspension, granules, powder, aqueous solution, oil, and microcapsule suspension, wherein the preferred formulations are wettable powder, suspension concentrate, and water-dispersible granules.

[0011] The agriculturally acceptable adjuvants and / or carriers described in this invention include, but are not limited to: dispersants, wetting agents, disintegrants, binders, separating agents, solvents, emulsifiers, co-emulsifiers, stabilizers, defoamers, thickeners, density adjusters, pH adjusters, antifreeze agents, preservatives, penetrants, and carriers.

[0012] When the composition is formulated into a wettable powder, it contains the following components and weight contents: 10%–50% dichloroisoxane, 0.1%–40% pyrazosulfuron, 10%–60% carrier, 3%–10% wetting agent, 3%–10% dispersant, 0.1%–3% defoamer, and filler to make up the balance.

[0013] For example, the preparation method can be as follows: first, the technical grade dichlorvos isoxaflutole is adsorbed onto a carrier and dried; then, the carrier adsorbed with dichlorvos isoxaflutole, the technical grade dichlorvos, the wetting agent, the dispersant, the defoamer, and the filler are mixed and homogenized in a mixing tank, and then pulverized by an air jet mill and mixed evenly again.

[0014] When the composition is formulated into a suspension, it contains the following components and weight contents: 10%–40% dichloroisoxane, 0.1%–10% pyrazosulfuron, 10%–50% carrier, 3%–10% dispersant, 0.1%–0.5% thickener, 2%–5% antifreeze, 0.1%–5% defoamer, 0.1%–1% preservative, and deionized water to make up the balance.

[0015] The preparation method can be as follows: First, dichloroisoxane technical is adsorbed onto a carrier and dried. Then, the carrier adsorbed with dichloroisoxane technical, pyrazosulfuron technical, dispersant, and some water are coarsely mixed in a homogenizer and then added to a sand mill for ultra-fine grinding. Finally, the remaining water containing thickener, antifreeze, defoamer, and preservative is added under the action of a homogenizer and fully mixed.

[0016] When the composition is formulated into water-dispersible granules, it contains the following components and weight contents: 10%–50% dichloroisoxane, 0.5%–30% pyrazosulfuron, 10%–60% carrier, 1%–3% wetting agent, 5%–20% dispersant, 0.1%–2% binder, 1%–5% disintegrant, 0.1%–2% release agent, 0.1%–5% defoamer, and filler to make up the balance.

[0017] The preparation method can be as follows: First, dichloroisoxane technical is adsorbed onto a carrier and dried. Then, the carrier with adsorbed dichloroisoxane technical, sulfadiazine technical, wetting agent, dispersant, binder, disintegrant, separating agent, and filler are added to water and ground. An antifoaming agent is then added under homogenization to obtain a slurry. The slurry is then sent to a drying tower for spray drying, and after sieving, the product is obtained.

[0018] The dispersant may be one or more of the following: sodium lignosulfonate, potassium lignosulfonate, ammonium lignosulfonate, sodium naphthalenesulfonate formaldehyde condensate, sodium dibutylnaphthalenesulfonate formaldehyde condensate, sodium methylnaphthalenesulfonate formaldehyde condensate, fatty alcohol ethylene oxide adduct phosphate, alkylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, polyoxyethylene polyoxypropylene ether block copolymer, and alkylphenol polyoxyethylene phosphate.

[0019] The wetting agent may be one or more of the following: pull-apart powder, sodium dodecylbenzene sulfonate, sodium lauryl sulfate, sodium dioctyl succinate sulfonate, sodium diisopropyl naphthalene sulfonate, nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, tridecyl alcohol polyoxyethylene ether, sodium dodecyl sulfate, fatty alcohol ethoxylate, alkylphenol ethoxylate, naphthalene sulfonate, and sodium octadecyl succinate.

[0020] The defoamer may be one or more of isooctanol, isoamyl alcohol, stearic acid, lauric acid, and ethylene oxide-propylene oxide block copolymer;

[0021] The thickener may be one or more of the following: xanthan gum, gelatin, gum arabic, magnesium aluminum silicate, diatomaceous earth, bentonite, polyacrylate, natural polysaccharide, xanthan gum, gypsum, clay, water glass, sodium carboxymethyl starch, soluble starch, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium alginate, and agar.

[0022] The antifreeze agent may be one or more of the following: ethylene glycol, propylene glycol, glycerol, polyethylene glycol, sorbitol, glycerin, urea, ammonium sulfate, glycerol-ethyl ether diethylene glycol, and methylpropylene diethylene glycol.

[0023] The preservative may be one or more of formaldehyde, sodium salicylate, sodium benzoate, 1,2-benzothiazolin-3-one, 2-hydroxybiphenyl, sorbic acid, benzoic acid, benzaldehyde, p-hydroxybenzaldehyde, and p-hydroxybenzoate.

[0024] The disintegrant can be one or more of thiamine, calcium chloride, and aluminum chloride;

[0025] The adhesive may be one or more of polyvinyl acetate polymer, polyvinyl alcohol, ethylene-vinyl acetate copolymer, and soluble starch;

[0026] The separating agent can be one or more of amorphous silica gel and aerosol silica gel.

[0027] The carrier and / or filler may be one or more of the following: silica, bentonite, kaolin, activated clay, attapulgite, diatomaceous earth, light calcium carbonate, talc, pyrophyllite, and clay.

[0028] A third aspect of the present invention relates to the use of the above-described herbicidal compositions and / or herbicides in the control of agricultural weeds.

[0029] Preferably, the herbicidal composition and / or herbicide is used to control weeds in wheat fields, such as large-spike alopecuroides, alopecuroides, Japanese alopecuroides, multiflora ryegrass, sedge, wild oats, jointed goatgrass, shepherd's purse, wheatgrass, speedwell, etc.

[0030] More preferably, the herbicidal composition and / or herbicide is used to control barnyardgrass, wild oats, and shepherd's purse in wheat fields.

[0031] Furthermore, the herbicidal composition or herbicide of the present invention reduces phytotoxicity to crops when controlling agricultural weeds. Tests show that the phytotoxicity to wheat is significantly less when dichlorvos is mixed with the herbicide dichlorvos compared to dichlorvos alone.

[0032] In the application described in this invention, the field application rate of the active ingredient of the herbicide composition and / or herbicide is 10–500 g / hm². 2 Preferred concentration: 100–300 g / hm 2 .

[0033] The methods of using the herbicidal composition or herbicide of the present invention include, but are not limited to, preparing a mixed formulation, using it in a tank, or adding other active ingredients or adjuvants.

[0034] The present invention has the following positive and beneficial effects:

[0035] 1. When dichlorvos and pyrazosulfuron are used in combination, the phytotoxicity to crops is significantly reduced compared to the use of dichlorvos alone.

[0036] 2. The combination of dichlorvos and pyrazosulfuron has a significant synergistic effect on weeds and provides good control over resistant weeds.

[0037] 3. Dichlorvos and pyrazosulfuron have different mechanisms of action, and their combined use can delay the development of herbicide resistance in weeds. Attached Figure Description

[0038] Figure 1 In the experimental examples, the effects of dichlorvos alone and the herbicidal composition of the present invention on wheat phytotoxicity were demonstrated. As shown in the figure, 216 g ai / hm of dichlorvos... 2 After treatment, wheat leaves suffered severe whitening and drying, wheat growth was severely affected, and overall herbicide damage was severe; dichloroisoxane 216g ai / hm 2 +pyrazosulfuron 18g ai / hm 2 After treatment, the wheat leaves only showed slight whitening, and the overall phytotoxicity was significantly reduced compared to the use of dichlorvos alone.

[0039] Figure 2 This figure shows the phytotoxicity of dichlorvos alone to wheat in a field demonstration. As can be seen from the figure, 216 g ai / hm of 36% dichlorvos suspension concentrate... 2 After treatment, the wheat heart leaves were severely whitened and yellowed, the growing point was severely inhibited, the wheat growth was severely affected, and the overall pesticide damage was severe and difficult to recover.

[0040] Figure 3 This figure shows the phytotoxicity of the herbicidal composition of the present invention to wheat in a field demonstration. As can be seen from the figure, the dosage in Formulation Example 5 was 234 g ai / hm. 2 (Dichloroisoxane dosage 216g ai / hm) 2 After treatment, the wheat leaves showed slight yellowing, but the growing points were not significantly affected. Overall, the pesticide damage was minor and the plant was able to recover. Detailed Implementation

[0041] The following embodiments are used to illustrate the present invention, but are not intended to limit the scope of the invention. Where specific techniques or conditions are not specified in the embodiments, they should be performed in accordance with the techniques or conditions described in the literature in the field, or in accordance with the product instructions. Unless otherwise specified, all percentage contents in all embodiments of the present invention refer to weight percentage contents.

[0042] (I) Formulation Examples

[0043] Formulation Example 1: 20% dichloroisoxane·pyrazosulfuron wettable powder

[0044] Dichloroisoxane 19.86%, pyrazosulfan 0.14%, silica 25%, sodium dodecylbenzene sulfonate 3%, potassium lignosulfonate 3%, stearic acid 0.2%, and light calcium carbonate to make up the balance.

[0045] First, dichloroisoxane technical material is uniformly adsorbed onto silica and dried. Then, silica with adsorbed dichloroisoxane technical material, pyrazosulfan technical material, sodium dodecylbenzene sulfonate, potassium lignosulfonate, stearic acid, and light calcium carbonate are mixed and homogenized in a mixing tank. After being pulverized by an air jet mill, they are mixed evenly again.

[0046] Formulation Example 2: 20% dichloroisoxane·pyrazosulfuron suspension

[0047] Dichloroisoxane 19.7%, pyrazosulfan 0.3%, silica 25%, sodium dibutylnaphthalene sulfonate formaldehyde condensate 2%, polyoxyethylene polyoxypropylene ether block copolymer 2%, gum arabic 0.3%, ammonium sulfate 2%, isooctyl alcohol 1%, sodium salicylate 0.5%, deionized water to make up the balance.

[0048] First, dichloroisoxane technical is uniformly adsorbed onto silica and dried. Then, silica with adsorbed dichloroisoxane technical, pyrazosulfan technical, sodium dibutylnaphthalene sulfonate formaldehyde condensate, polyoxyethylene polyoxypropylene ether block copolymer, and some water are coarsely mixed in a homogenizer and then added to a sand mill for ultra-fine grinding. Finally, the remaining water containing dissolved gum arabic, ammonium sulfate, isooctyl alcohol, and sodium salicylate is added under the action of a homogenizer and thoroughly mixed.

[0049] Formulation Example 3: 25% dichloroisoxane·pyrazosulfuron-methyl water-dispersible granules

[0050] Dichloroisoxane 24.3%, pyrazosulfan 0.7%, silica 30%, fatty alcohol ethoxylate 1%, sodium dibutylnaphthalene sulfonate formaldehyde condensate 4%, polyoxyethylene polyoxypropylene ether block copolymer 4%, ethylene-vinyl acetate copolymer 0.5%, calcium chloride 1%, aerosol silica gel 0.5%, stearic acid 0.5%, bentonite to make up the balance.

[0051] First, dichloroisoxane technical grade is uniformly adsorbed onto silica and dried. Then, silica containing dichloroisoxane technical grade, pyrazosulfan technical grade, fatty alcohol ethoxylate, sodium dibutylnaphthalene sulfonate formaldehyde condensate, polyoxyethylene polyoxypropylene ether block copolymer, ethylene-vinyl acetate copolymer, calcium chloride, aerosol silica gel, and bentonite are added to water and ground. Stearic acid is then added under homogenization to obtain a slurry. The slurry is then spray-dried in a drying tower and sieved to obtain the final product.

[0052] Formulation Example 4: 30% dichloroisoxane·pyrazosulfuron wettable powder

[0053] Dichloroisoxane 28.9%, pyrazosulfuron 1.1%, silica 35%, coagulant 4%, calcium lignosulfonate 4%, isooctyl alcohol 0.3%, bentonite to make up the balance.

[0054] First, the dichloroisoxane technical material is uniformly adsorbed onto silica and dried. Then, silica with adsorbed dichloroisoxane technical material, pyrazosulfuron technical material, sizing agent, calcium lignosulfonate, isooctyl alcohol, and bentonite are mixed and stirred in a mixing tank. After being pulverized by an air jet mill, they are mixed evenly again.

[0055] Formulation Example 5: 25% dichloroisoxane·pyrazosulfuron suspension concentrate

[0056] Dichloroisoxane 23.1%, pyrazosulfanilamide 1.9%, silica 30%, alkylphenol polyoxyethylene ether phosphate 3%, polyoxyethylene polyoxypropylene ether block copolymer 3%, magnesium aluminum silicate 0.3%, polyethylene glycol 2%, stearic acid 1%, sodium benzoate 0.5%, deionized water to make up the balance.

[0057] First, dichloroisoxane technical is uniformly adsorbed onto silica and dried. Then, silica with adsorbed dichloroisoxane technical, sulfadiazine technical, alkylphenol polyoxyethylene ether phosphate, polyoxyethylene polyoxypropylene ether block copolymer, and some water are coarsely mixed in a homogenizer and then added to a sand mill for ultra-fine grinding. Finally, the remaining water containing dissolved magnesium aluminum silicate, polyethylene glycol, stearic acid, and sodium benzoate is added under the action of a homogenizer and thoroughly mixed.

[0058] Formulation Example 6: 30% dichloroisoxane·pyrazosulfuron-methyl water-dispersible granules

[0059] Dichloroisoxane 27%, pyrazosulfanilamide 3%, silica 30%, alkylphenol ethoxylate 2%, fatty alcohol ethylene oxide adduct phosphate 5%, alkylphenol polyoxyethylene phosphate 5%, polyvinyl acetate polymer 1%, aluminum chloride 2%, amorphous silica gel 1%, isooctanol 0.5%, kaolin to make up the balance.

[0060] First, dichloroisoxane technical grade is uniformly adsorbed onto silica and dried. Then, silica containing dichloroisoxane technical grade, sulfadiazine technical grade, alkylphenol ethoxylate, fatty alcohol ethylene oxide adduct phosphate, alkylphenol polyoxyethylene phosphate, polyvinyl acetate polymer, aluminum chloride, amorphous silica gel, and kaolin are added to water and ground. Isooctol is then added under homogenization to obtain a slurry. The slurry is then spray-dried in a drying tower and sieved to obtain the final product.

[0061] Formulation Example 7: 40% dichloroisoxane·pyrazosulfuron wettable powder

[0062] Dichloroisoxane 36%, pyrazosulfuron 4%, silica 40%, sodium lauryl sulfate 4%, sodium naphthalenesulfonate formaldehyde condensate 4%, isoamyl alcohol 0.4%, kaolin to make up the balance.

[0063] First, dichloroisoxane technical material is uniformly adsorbed onto silica and dried. Then, silica with adsorbed dichloroisoxane technical material, pyrazosulfate technical material, sodium lauryl sulfate, sodium naphthalene sulfonate formaldehyde condensate, isoamyl alcohol, and kaolin are mixed and homogenized in a mixing tank. After being pulverized by an air jet mill, they are mixed evenly again.

[0064] Formulation Example 8: 30% dichloroisoxane·pyrazosulfuron suspension

[0065] Dichloroisoxane 25.3%, pyrazosulfuron 4.7%, silica 30%, fatty alcohol ethylene oxide adduct phosphate 4%, alkylphenol polyoxyethylene phosphate 4%, gelatin 0.4%, sorbitol 2.5%, lauric acid 1.5%, paraben 0.5%, deionized water to make up the balance.

[0066] First, dichloroisoxane technical is uniformly adsorbed onto silica and dried. Then, silica with adsorbed dichloroisoxane technical, pyrazosulfuron technical, fatty alcohol ethylene oxide adduct phosphate, alkylphenol polyoxyethylene phosphate, and some water are coarsely mixed in a homogenizer and then added to a sand mill for ultra-fine grinding. Finally, the remaining water containing dissolved gelatin, sorbitol, lauric acid, and parabens is added under the action of a homogenizer and thoroughly mixed.

[0067] Formulation Example 9: 40% dichloroisoxane·pyrazosulfuron-methyl water-dispersible granules

[0068] Dichloroisoxane 25.7%, pyrazosulfan 14.3%, silica 30%, sodium octadecyl succinate 1%, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate 5%, alkylphenol polyoxyethylene phosphate 5%, soluble starch 1%, thiamine 2%, aerosol silica 1%, lauric acid 0.5%, diatomaceous earth to make up the balance.

[0069] First, dichloroisoxane technical grade is uniformly adsorbed onto silica and dried. Then, silica containing dichloroisoxane technical grade, sulfadiazine technical grade, sodium octadecyl succinate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylphenol polyoxyethylene phosphate, soluble starch, thiamine, aerosol silica, and diatomaceous earth are added to water and ground. Lauric acid is then added under homogenization to obtain a slurry. The slurry is then spray-dried in a drying tower and sieved to obtain the final product.

[0070] Formulation Example 10: 50% dichloroisoxane·pyrazosulfuron wettable powder

[0071] Dichloroisoxane 20.9%, pyrazosulfan 29.1%, silica 25%, tridecanol polyoxyethylene ether 5%, sodium naphthalene sulfonate formaldehyde condensate 5%, lauric acid 0.5%, diatomaceous earth to make up the balance.

[0072] First, dichloroisoxane technical material is uniformly adsorbed onto silica and dried. Then, silica with adsorbed dichloroisoxane technical material, pyrazosulfan technical material, tridecanol polyoxyethylene ether, sodium naphthalene sulfonate formaldehyde condensate, lauric acid, and diatomaceous earth are mixed and homogenized in a mixing tank. After being pulverized by an air jet mill, they are mixed evenly again.

[0073] (II) Indoor Biometrics Example

[0074] The indoor bioassay examples of this invention were conducted according to the "Guidelines for Indoor Bioassay Testing of Pesticides - Herbicides Part 7: Determination of Combined Effects of Mixed Herbicides (NY / T 1155.7—2006)". Through indoor bioassays, the combined effects of two pesticides mixed in a certain proportion on crops and weeds were clarified. The test methods are as follows:

[0075] Accurately weigh 5.21 g of 96% dichloroisoxane technical grade and dissolve it in 100 mL of petroleum ether to prepare a dichloroisoxane stock solution with a concentration of 50 g / L. Accurately weigh 0.21 g of 96.5% sulfadiazine technical grade and dissolve it in 50 mL of acetonitrile:water = 3:1 (v / v) to prepare a sulfadiazine stock solution with a concentration of 4 g / L. During the experiment, take appropriate amounts of the dichloroisoxane stock solution and the sulfadiazine stock solution respectively, and dilute them with an appropriate amount of 0.1% TWA80 aqueous solution to prepare the test solutions.

[0076] A pot experiment was conducted, targeting wheat and major weeds in wheat fields, including barnyardgrass, wild oats, and shepherd's purse. Seedlings were raised in plastic pots (12cm in diameter, 11cm in height) in a greenhouse. Before application of the herbicide, seedlings were thinned to 10 uniform wheat or weed plants per pot. Foliar spraying was applied at the 3-4 leaf stage, with each treatment repeated 8 times, at a concentration of 450 L / hm². 2 Fourteen days after application, weigh the fresh weight of the top layer of wheat or weeds in each pot and calculate the actual phytotoxicity rate / control efficacy E for each treatment:

[0077]

[0078] In the formula: PT—fresh weight of the drug-treated group;

[0079] CK – Fresh weight of the blank control group.

[0080] The Gowing method was used to evaluate the combined effect of two herbicides in a certain proportion on wheat or weeds. The formula for calculating the theoretical phytotoxicity rate / control efficacy E0 after combination is as follows:

[0081]

[0082] In the formula: X — phytotoxicity rate / control efficacy when herbicide A is applied at a dosage of P;

[0083] Y – Herbicide damage rate / control efficacy when herbicide B is applied at a dosage of Q;

[0084] E0 – The theoretical phytotoxicity rate / control efficacy after mixing herbicide A at dosage P and herbicide B at dosage Q;

[0085] E – Actual phytotoxicity / control efficacy after mixing herbicide A (at dosage P) and herbicide B (at dosage Q).

[0086] E-E0 > 10% indicates a synergistic effect; E-E0 < -10% indicates an antagonistic effect; -10% < E-E0 < 10% indicates an additive effect.

[0087] Indoor bioassay example 1:

[0088] The target crop was wheat (Jimai 22). The dosage and efficacy of each treatment are shown in Table 1. Biochemical tests showed that when the ratio of dichlorvos to isoxaflutole was between 1:0.007 and 1.4, the E-E0 value was -21.6% to -11.2%, indicating that the mixture of the two crops in this range had a significant antagonistic effect on wheat herbicide damage and could significantly reduce the damage. When the ratio of dichlorvos to isoxaflutole was between 1:0.01 and 0.2, the E-E0 value was -21.6% to -13.9%, indicating that the antagonistic effect on wheat herbicide damage was even more pronounced when the mixture of the two crops in this range. When the ratio of dichlorvos to isoxaflutole is in the range of 1:0.02-0.15, the E-E0 value is -21.6% to -16.4%, indicating that the antagonistic effect of the two on wheat herbicide damage is most obvious when mixed in the range of 1:0.02-0.15.

[0089] Table 1. Results of bioassays on wheat using different ratios of dichloroisoxane and pyrazosulfuron.

[0090]

[0091]

[0092] Indoor bioassay example 2:

[0093] The target species tested was *Alopecurus aequalis*, and the dosage and efficacy of each treatment are shown in Table 2. Biochemical tests showed that when the ratio of dichlorvos to isoxaflutole was within the range of 1:0.007-1.4, the E-E0 value was 11.3%-17.4%, indicating that the mixture of the two herbicides within this range had a significant synergistic effect on *Alopecurus aequalis*. When the ratio of dichlorvos to isoxaflutole was within the range of 1:0.01-0.2, the E-E0 value was 13.2%-17.4%, indicating that the mixture of the two herbicides within this range had an even more significant synergistic effect on *Alopecurus aequalis*. When the ratio of dichlorvos to isoxaflutole is in the range of 1:0.02-0.15, the E-E0 value is 15.4% to 17.4%, indicating that the combination of the two in the range of 1:0.02-0.15 has the most significant synergistic effect on large-spike wheatgrass.

[0094] Table 2. Results of the effects of different ratios of dichloroisoxane and pyrazosulfuron on the growth of *Alopecurus aequalis*.

[0095]

[0096]

[0097] Indoor bioassay example 3:

[0098] The target plant was *Brassica napus*, and the dosage and efficacy of each treatment are shown in Table 3. Biochemical tests showed that when the ratio of dichlorvos to isoxaflutole was between 1:0.007 and 1.4, the E-E0 value was 11.9%–26.1%, indicating that the mixture of the two plants within this range had a significant synergistic effect on *Brassica napus*. When the ratio of dichlorvos to isoxaflutole was between 1:0.01 and 0.2, the E-E0 value was 16.8%–26.1%, indicating that the synergistic effect was even more pronounced when the mixture was within this range. When the ratio of dichlorvos to isoxaflutole was between 1:0.02 and 0.15, the E-E0 value was 21.4%–26.1%, indicating that the synergistic effect was most significant when the mixture was within this range.

[0099] Table 3. Results of bioassays on bromelain and pyrazosulfuron in different ratios.

[0100]

[0101] Indoor bioassay example 4:

[0102] The target plant was shepherd's purse. The dosage and efficacy of each treatment are shown in Table 3. Biochemical tests showed that when the ratio of dichlorvos to chlorpyrifos was between 1:0.007 and 1.4, the E-E0 value was 14.2%–27.3%, indicating that the mixture of the two in this range had a significant synergistic effect on shepherd's purse. When the ratio of dichlorvos to chlorpyrifos was between 1:0.01 and 0.2, the E-E0 value was 21.6%–27.3%, indicating that the synergistic effect was even more pronounced when the mixture was between 1:0.01 and 0.2. When the ratio of dichlorvos to chlorpyrifos was between 1:0.02 and 0.15, the E-E0 value was 24.1%–27.3%, indicating that the synergistic effect was most significant when the mixture was between 1:0.02 and 0.15.

[0103] Table 4. Results of the bioassay of different ratios of dichloroisoxane and pyrazosulfuron on shepherd's purse.

[0104]

[0105] (III) Examples of Field Efficacy Trials

[0106] The field efficacy test examples of this invention were conducted in accordance with the "Guidelines for Field Efficacy Tests of Pesticides (I) Herbicides for Weed Control in Wheat Crops (GB / T 17980.41-2000)". Field plot trials were used to verify the results of indoor bioassays and to clarify the effect of the two agents, when combined in a certain proportion, on reducing phytotoxicity to wheat and their field control effect on weeds. The test methods are as follows:

[0107] Foliar spraying at the 3-5 leaf stage after winter wheat sowing (mid-November), with a solution volume of 450 L / hm². 2 Each treatment was repeated four times, with a plot size of 125 m², arranged in a randomized block design. A survey was conducted 15 days post-treatment. Four sampling points were randomly selected from each plot to investigate the aboveground fresh weight of all wheat seedlings or all weeds within each sampling point. Each wheat sampling point was 0.25 m². 2 Each weed sampling point is 1m in size. 2 Calculate the actual phytotoxicity rate / control efficacy E for each treatment:

[0108]

[0109] In the formula: PT—fresh weight of wheat / weeds in the treated area;

[0110] CK – Fresh weight of wheat / weeds in the blank control area.

[0111] The data obtained from the survey, referencing the "Guidelines for Indoor Bioassay Testing of Pesticides - Herbicides Part 7: Determination of Combined Effects of Mixed Herbicides (NY / T 1155.7—2006)," used the Gowing method to evaluate the combined effects of two herbicides mixed in a certain proportion on wheat or weeds. The formula for calculating the theoretical phytotoxicity rate / control efficacy E0 after mixing is as follows:

[0112]

[0113] In the formula: X — phytotoxicity rate / control efficacy when herbicide A is applied at a dosage of P;

[0114] Y – Herbicide damage rate / control efficacy when herbicide B is applied at a dosage of Q;

[0115] E0 – The theoretical phytotoxicity rate / control efficacy after mixing herbicide A at dosage P and herbicide B at dosage Q;

[0116] E – Actual phytotoxicity / control efficacy after mixing herbicide A (at dosage P) and herbicide B (at dosage Q).

[0117] E-E0 > 10% indicates a synergistic effect; E-E0 < -10% indicates an antagonistic effect; -10% < E-E0 < 10% indicates an additive effect.

[0118] The experiment was conducted in Wagu Village, Nanhe District, Xingtai City, Hebei Province. The wheat variety was Tianci Mai No. 1. The main weeds in the field were large-spike wheatgrass and shepherd's purse, and the weeds were evenly distributed.

[0119] Table 5 shows the dosage of each pesticide and the rate of phytotoxicity to wheat. Field trial results indicated that the effective dosage of dichloroisoxane was 162 g / hm². 2 The phytotoxicity rate of dichloroisoxane single agent to wheat was 19.4%, while the phytotoxicity rate of the composition described in this invention to wheat was 3.0% to 7.6%, with an E-E0 value of -16.4% to -18.7%; the effective ingredient dosage of dichloroisoxane was 216 g / hm. 2 The phytotoxicity rate of dichloroisoxane single agent to wheat was 24.7%, while the phytotoxicity rate of the composition of the present invention was 6.9% to 8.9%, with an E-E0 value of -22.3% to -17.8%. Compared with dichloroisoxane single agent, the dichloroisoxane and pyrazosulfuron combination of the present invention significantly reduces the phytotoxicity rate to wheat under the same dosage of dichloroisoxane active ingredient. This indicates that in practical applications, the composition of the present invention has a significant antagonistic effect on wheat phytotoxicity and can significantly reduce the phytotoxicity caused by dichloroisoxane single agent to wheat.

[0120] Table 5. Results of field trials on wheat herbicide damage caused by the combined use of dichloroisoxane and acesulfame K.

[0121]

[0122]

[0123] Table 6 shows the dosage of each treatment agent and its efficacy against weeds in wheat fields. Field trial results show that the E-E0 value of the dichlorvos-isoxane and pyrazosulfuron-methyl combination described in this invention is 12.7% to 15.3% for overall control of Alopecurus aequalis and Capsella bursa-pastoris in wheat fields, indicating that the combination described in this invention has a significant synergistic effect on weeds in wheat fields in practical applications.

[0124] Table 6. Field efficacy test results of dichlorvos and acesulfame potassium against weeds in wheat fields.

[0125]

[0126] Therefore, the dichloroisoxane and pyrazosulfuron-methyl composition of the present invention, without the need for the addition of a safener, can significantly reduce phytotoxicity to crops and improve weed control efficacy by virtue of their unique interaction mechanism and their interaction mechanism with crops or weeds. It is an ideal herbicide.

[0127] This invention has been described through specific embodiments. Those skilled in the art can refer to the content of this invention and appropriately modify the raw materials, process conditions, and other aspects to achieve other corresponding objectives. Such modifications do not depart from the content of this invention, and all similar substitutions and alterations are considered to be included within the scope of this invention, as they do not depart from the spirit of this invention.

Claims

1. A herbicidal composition containing dichloroisoxane and pyrazosulfuron, characterized in that, The weight ratio of dichloroisoxane to pyrazosulfuron is 1:0.007-1.

4.

2. The herbicidal composition according to claim 1, characterized in that, The weight ratio of dichloroisoxane to pyrazosulfuron is 1:0.01-0.

2.

3. The herbicidal composition according to any one of claims 1 or 2, characterized in that, The weight ratio of dichloroisoxane to pyrazosulfuron is 1:0.02-0.

15.

4. A herbicide comprising the herbicidal composition according to any one of claims 1-3.

5. The herbicide according to claim 4, characterized in that, The dichloroisoxane and pyrazosulfuron account for 5% to 90% of the total weight.

6. The herbicide according to any one of claims 4 or 5, characterized in that, The herbicidal composition may be prepared into any pesticide-acceptable formulation selected from wettable powders, suspensions, water-dispersible granules, suspension emulsions, microemulsions, water-in-oil emulsions, emulsifiable concentrates, oil suspensions, soluble powders, dry suspensions, aqueous solutions, and microcapsule suspensions.

7. The application of a herbicidal composition according to any one of claims 1-3 or a herbicide according to any one of claims 4-6 in controlling weeds in wheat fields, characterized in that, The weeds mentioned are barnyardgrass, wild oats, and shepherd's purse.

8. The application according to claim 7, characterized in that, The effective ingredient of the herbicide composition or herbicide is applied at a concentration of 10-500 g / hm². 2 .

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