A traditional Chinese medicine composition for preventing and treating cat stomatitis, and a preparation method and application thereof

Abstract

The application discloses a traditional Chinese medicine composition for preventing and treating cat stomatitis and a preparation method and application thereof, and comprises the following components in parts by weight: liquorice 2-20 parts, honeysuckle 4-10 parts, ophiopogon 4-10 parts, root of red peony 4-8 parts, scrophularia 4-8 parts, coptis 4-8 parts, radix codonopsitis 4-8 parts and jujube 4-8 parts. The liquorice, scrophularia and coptis in the traditional Chinese medicine composition have the effects of clearing heat and detoxifying, clearing heat and drying dampness, and have certain anti-inflammatory effect; the honeysuckle has the effects of clearing heat and detoxifying and dispelling wind-heat, the ophiopogon has the effects of nourishing yin and generating fluid and moistening lung and clearing heart, the root of red peony has the effects of clearing heat and cooling blood and activating blood and resolving stasis, can achieve the effects of nourishing yin and activating blood and improving metabolism of the body, the radix codonopsitis has the effects of tonifying spleen and lung, nourishing blood and generating fluid, the jujube has the effects of tonifying middle and replenishing qi, nourishing blood and tranquilizing, can regulate immunity of the body, reduce stress of the cat and promote recovery of the disease. Thus, the cat stomatitis is controlled, and problems of decreased appetite, reduced weight, painful eating and lack of spirit of the cat caused by the stomatitis are improved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceuticals, specifically to a traditional Chinese medicine formula for the prevention and treatment of feline stomatitis, its preparation method, and its application. Background Technology

[0002] As people's living standards improve, more and more people are treating pets as family members. Pets are gaining a higher status within the family, leading to increased spending by pet owners. Stomatitis is a common disease in cats, and its treatment is difficult, posing a significant challenge for both pet owners and veterinarians.

[0003] Feline stomatitis, also known as feline chronic gingivostomatitis (FCGS), is a common but complex disease affecting the oral mucosa in cats. It typically manifests as severe inflammation of the oral cavity, including the gums, oral mucosa, and pharynx. This inflammation causes significant discomfort and pain in cats, severely impacting their quality of life.

[0004] Typical symptoms include swelling, pain, ulcers, drooling, and bad breath in the mouth. Cats may exhibit difficulty eating, decreased appetite, and weight loss. Due to pain, affected cats may avoid eating and even exhibit behavioral changes, such as becoming more withdrawn or aggressive. The exact cause of feline stomatitis is not fully understood, but it is generally believed to be related to an abnormal response of the immune system. Some studies suggest that pathogens such as feline herpesvirus and feline stomatitis rheumatoid virus may be triggering factors. In addition, genetic factors, environmental stress, nutritional status, and oral hygiene may also be associated with the development of feline stomatitis. An imbalance in the oral microbiota may lead to an overreaction of the immune system, triggering inflammation.

[0005] Treatment for feline stomatitis typically involves medication and surgical intervention. Medication may include anti-inflammatory drugs (such as corticosteroids), immunomodulators, and antibiotics (to control secondary infections). In severe cases, surgery may be necessary, requiring partial or complete tooth extraction. This method can reduce the immune system's response to the tooth surfaces in the mouth, but it also causes harm and pain to the cat. Furthermore, tooth extraction only significantly improves the condition in about 50% of cats. While steroids and antibiotics can provide ideal short-term treatment for feline stomatitis, long-term use carries potential risks. Although steroids effectively reduce inflammatory symptoms, they can lead to immunosuppression, increasing the risk of infection. Long-term use may also cause endocrine problems such as Cushing's syndrome, as well as gastrointestinal ulcers and liver burden. Additionally, while antibiotics can control secondary infections, improper use can lead to bacterial resistance and disrupt the normal gut microbiota, causing indigestion or allergic reactions. Moreover, these treatments often focus on symptom control rather than addressing the underlying cause of stomatitis, potentially leading to recurring symptoms and a poor prognosis. Therefore, a new alternative treatment is needed for feline stomatitis. The advantages of using traditional Chinese medicine to treat feline stomatitis are mainly reflected in its gentleness and comprehensive conditioning characteristics.

[0006] Traditional Chinese medicine (TCM) generally carries a lower risk of side effects, especially with long-term use, which is particularly important in avoiding the potential side effects of steroids and antibiotics. The components of TCM are mostly derived from nature, making them generally gentler on the animal's physiological system. Furthermore, TCM treatment emphasizes holistic regulation and restoring the body's balance, focusing not only on symptom treatment but also on improving overall health and enhancing immunity. Therefore, this invention provides a TCM formula for the prevention and treatment of feline stomatitis, its preparation method, and its application. Summary of the Invention

[0007] Purpose of the invention: The technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition for the prevention and treatment of feline stomatitis, addressing the shortcomings of the prior art.

[0008] Another technical problem that this invention aims to solve is to provide a traditional Chinese medicine extract for the prevention and treatment of feline stomatitis.

[0009] Another technical problem that this invention aims to solve is to provide a traditional Chinese medicine preparation for the prevention and treatment of feline stomatitis.

[0010] Another technical problem to be solved by the present invention is to provide a method for preparing the above-mentioned traditional Chinese medicine composition, traditional Chinese medicine extract and traditional Chinese medicine preparation for preventing and treating feline stomatitis.

[0011] Another technical problem to be solved by the present invention is to provide the application of the above-mentioned traditional Chinese medicine composition, traditional Chinese medicine extract and traditional Chinese medicine preparation for preventing and treating feline stomatitis.

[0012] Invention Concept: This invention analyzes the mechanism of feline stomatitis and uses traditional Chinese medicine (TCM) formulas to treat feline stomatitis. The main causes of feline stomatitis are inflammation of the oral cavity and digestive tract caused by immune system abnormalities and pathogen infections. Clinical symptoms mainly include pain, oral inflammation, decreased appetite, halitosis, drooling, swollen submandibular lymph nodes, weight loss, and lethargy. Based on this disease analysis, this invention provides a TCM composition, TCM extract, and TCM preparation. The TCM composition has the effects of clearing heat and detoxifying, anti-inflammatory, tonifying the middle energizer and replenishing qi, regulating immunity, nourishing yin and cooling blood, and has a good effect on feline stomatitis caused by various reasons.

[0013] To solve the above-mentioned technical problems, the present invention discloses the following technical solution:

[0014] In a first aspect, the present invention discloses a traditional Chinese medicine composition for preventing and treating feline stomatitis, comprising the following raw materials: licorice, honeysuckle, ophiopogon japonicus, peony bark, scutellaria baicalensis, coptis chinensis, codonopsis pilosula, and jujube.

[0015] The roles of each herb in the composition within the formula are as follows:

[0016] (1) Licorice has the effects of tonifying the spleen and replenishing qi, clearing heat and detoxifying, and can be used for symptoms such as spleen qi deficiency and sore throat.

[0017] (2) Honeysuckle has the effects of clearing heat and detoxifying, and dispersing wind-heat. It is mainly used to treat carbuncles, boils and toxic sores, and wind-heat syndrome.

[0018] (3) Ophiopogon japonicus has the effects of nourishing yin and promoting body fluid, moistening the lungs and clearing the heart. It is used for lung and stomach yin deficiency and restlessness.

[0019] (4) Danpi has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis.

[0020] (5) Scutellaria baicalensis has the effects of clearing heat and drying dampness, purging fire and detoxifying.

[0021] (6) Coptis chinensis also has the effects of clearing heat and detoxifying, purging fire and detoxifying.

[0022] (7) Codonopsis pilosula has the effects of tonifying the spleen and lungs, nourishing blood and promoting body fluid production.

[0023] (8) Jujube has the effects of replenishing qi and blood and calming the mind.

[0024] Among them, licorice root tonifies the spleen and replenishes qi, clears heat and detoxifies, serving as the principal herb; scutellaria root clears heat and dries dampness, drains fire and detoxifies; coptis root also clears heat and detoxifies, serving as the assistant herb; honeysuckle clears heat and detoxifies, disperses wind-heat; ophiopogon root nourishes yin and generates fluids, moistens the lungs and clears the heart; peony bark clears heat and cools the blood, invigorates blood and removes blood stasis, serving as the adjuvant herb; codonopsis root tonifies the spleen and lungs, nourishes blood and generates fluids; jujube tonifies the middle jiao and replenishes qi, nourishes blood and calms the mind, serving as the guiding herb. The combined effects of these herbs are to tonify qi and strengthen the spleen, clear heat and detoxify, drain fire and dry dampness, nourish blood and generate fluids, cool blood and invigorate blood. By regulating the spleen and stomach, cardiopulmonary function, regulating metabolism and the immune system, reducing inflammatory markers, and promoting the repair of oral and digestive tract mucosa, the treatment aims to prevent and treat feline stomatitis.

[0025] In some embodiments, the traditional Chinese medicine composition for preventing and treating feline stomatitis comprises the following components in parts by weight: 2-20 parts of licorice, 4-10 parts of honeysuckle, 4-10 parts of ophiopogon japonicus, 4-8 parts of peony bark, 4-8 parts of scutellaria baicalensis, 4-8 parts of coptis chinensis, 4-8 parts of codonopsis pilosula, and 4-8 parts of jujube; in some embodiments, the parts by weight of licorice are selected from 3-18 parts, 4-16 parts, 5-15 parts, 6-14 parts, 7-13 parts, 8-12 parts, 9-11 parts, or 10 parts.

[0026] In some embodiments, the traditional Chinese medicine composition for preventing and treating feline stomatitis comprises the following components in parts by weight: 5-15 parts licorice root, 6-8 parts honeysuckle, 6-8 parts ophiopogon japonicus, 5-7 parts peony bark, 5-7 parts scutellaria baicalensis, 5-7 parts coptis chinensis, 5-7 parts codonopsis pilosula, and 5-7 parts jujube.

[0027] In some embodiments, the traditional Chinese medicine composition for preventing and treating feline stomatitis comprises the following components in parts by weight: 10 parts licorice, 7 parts honeysuckle, 7 parts ophiopogon japonicus, 6 parts peony bark, 6 parts scutellaria baicalensis, 6 parts coptis chinensis, 6 parts codonopsis pilosula, and 6 parts jujube.

[0028] Secondly, this invention discloses a traditional Chinese medicine extract for the prevention and treatment of feline stomatitis.

[0029] The herbal extract for preventing and treating feline stomatitis is made from the following ingredients: licorice, honeysuckle, ophiopogon japonicus, peony bark, scutellaria baicalensis, coptis chinensis, codonopsis pilosula, and jujube.

[0030] In some embodiments, the herbal extract for preventing and treating feline stomatitis is made from raw materials comprising the following components in parts by weight: 2-20 parts licorice, 4-10 parts honeysuckle, 4-10 parts ophiopogon japonicus, 4-8 parts peony bark, 4-8 parts scutellaria baicalensis, 4-8 parts coptis chinensis, 4-8 parts codonopsis pilosula, and 4-8 parts jujube.

[0031] In some embodiments, the herbal extract for preventing and treating feline stomatitis is made from raw materials comprising the following components in parts by weight: 2-20 parts licorice, 4-10 parts honeysuckle, 4-10 parts ophiopogon japonicus, 4-8 parts peony bark, 4-8 parts scutellaria baicalensis, 4-8 parts coptis chinensis, 4-8 parts codonopsis pilosula, and 4-8 parts jujube; in some embodiments, the parts by weight of licorice are selected from 3-18 parts, 4-16 parts, 5-15 parts, 6-14 parts, 7-13 parts, 8-12 parts, 9-11 parts, or 10 parts.

[0032] In some embodiments, the herbal extract for preventing and treating feline stomatitis is made from raw materials comprising the following components in parts by weight: 5-15 parts licorice, 6-8 parts honeysuckle, 6-8 parts ophiopogon japonicus, 5-7 parts peony bark, 5-7 parts scutellaria baicalensis, 5-7 parts coptis chinensis, 5-7 parts codonopsis pilosula, and 5-7 parts jujube.

[0033] In some embodiments, the herbal extract for preventing and treating feline stomatitis is made from raw materials comprising the following components in parts by weight: 10 parts licorice, 7 parts honeysuckle, 7 parts ophiopogon japonicus, 6 parts peony bark, 6 parts scutellaria baicalensis, 6 parts coptis chinensis, 6 parts codonopsis pilosula, and 6 parts jujube.

[0034] Thirdly, this invention discloses a traditional Chinese medicine preparation for the prevention and treatment of feline stomatitis.

[0035] The traditional Chinese medicine preparation includes (i) the product after extraction and drying of the traditional Chinese medicine composition described in the first aspect above or the traditional Chinese medicine extract described in the second aspect above, and (ii) pharmaceutically acceptable excipients or carriers.

[0036] The pharmaceutically acceptable excipients or carriers include starch.

[0037] The dosage form of the traditional Chinese medicine preparation includes capsules.

[0038] Fourthly, the present invention discloses the preparation methods of the above-mentioned Chinese herbal extracts and the above-mentioned Chinese herbal preparations.

[0039] The preparation method of the Chinese herbal extract includes weighing each component according to the weight proportions, soaking in water, decocting, concentrating, filtering, and spray drying for later use.

[0040] In some embodiments, the mass of the water is 5-15 times the total mass of the components; the soaking time is 10-60 min; the decoction time is 10-50 min per time, and a total of 1-3 decoctions are performed; in some embodiments, the amount of deionized water added for the first time is 10 times the mass of the medicinal material, and the amount of deionized water added for the second time is 8 times the mass of the medicinal material. After combining the two filtrates, the mixture is filtered twice to remove insoluble impurities. The concentration is performed using a rotary evaporator, and the concentration is adjusted to 50°C until the density of the concentrate is 1.2-1.25. The concentrate is then placed in a spray dryer to obtain spray-dried powder.

[0041] In some embodiments, the preparation method of the traditional Chinese medicine extract includes weighing the above traditional Chinese medicine components according to the proportion, adding 10 times the amount of water, decocting for 1.5 hours, filtering, adding 8 times the amount of water again, decocting for 1 hour, combining the two filtrates, filtering twice to remove insoluble impurities, concentrating using a rotary evaporator at 50°C so that 1 ml of the concentrate contains 3 g of the original medicinal material, and then spray drying to obtain the spray-dried powder of the traditional Chinese medicine formula.

[0042] In some embodiments, the preparation method of the traditional Chinese medicine extract includes mixing the traditional Chinese medicines according to the prescription ratio, pulverizing them with a pulverizer, passing them through a 10-mesh sieve, accurately weighing 100g of powder, adding 10 times the amount of deionized water, soaking for 30 minutes, then rapidly boiling over high heat and continuing to boil over low heat for 30 minutes, filtering out the decoction containing the medicine, adding an equal amount of deionized water again, and repeating the decoction. The filtrates from the two decoctions are combined, allowed to stand for 60 minutes to settle, and then filtered twice to remove impurities. The entire filtrate is then concentrated in a rotary evaporator at 50℃. After the concentrated liquid is placed at room temperature, it is spray-dried to obtain the dried powder of the traditional Chinese medicine prescription.

[0043] In some embodiments, the method for preparing the pharmaceutical preparation includes adding excipients to a dried powder of a traditional Chinese medicine formula to prepare the pharmaceutical preparation.

[0044] In some embodiments, the capsule preparation method involves adding 15%-25% starch (by mass) to a traditional Chinese medicine extract, mixing, and then filling with an automated capsule filler to produce capsules.

[0045] Fifthly, the present invention discloses the application of the above-mentioned traditional Chinese medicine composition, the above-mentioned traditional Chinese medicine extract and the above-mentioned traditional Chinese medicine preparation in the preparation of products for the prevention and treatment of feline stomatitis.

[0046] The product package contains pharmaceuticals.

[0047] In this invention, medication is administered according to the animal's body weight, based on the different stages and symptoms of the disease. The administration regimen for cats is as follows:

[0048] Table 1. Dosing regimen for cats

[0049]

[0050] The prevention and control measures described in this invention include prevention and treatment.

[0051] Beneficial effects:

[0052] The traditional Chinese medicine composition provided by this invention contains licorice, scutellaria, and coptis, which have the effects of clearing heat and detoxifying, clearing heat and drying dampness, and have a certain anti-inflammatory effect; honeysuckle clears heat and detoxifies, and disperses wind-heat; ophiopogon nourishes yin and generates fluids, moistens the lungs and clears the heart; peony bark clears heat and cools the blood, and promotes blood circulation and removes blood stasis, thus achieving the effects of nourishing yin and promoting blood circulation, and improving the body's metabolism; codonopsis tonifies the spleen and lungs, nourishes blood and generates fluids; jujube tonifies the middle and benefits qi, nourishes blood and calms the mind, and can regulate the body's immunity, reduce stress in cats and promote disease recovery. This controls feline stomatitis and can also improve problems such as decreased appetite, weight loss, pain when eating, and lethargy caused by stomatitis in cats.

[0053] Compared with dosage forms such as granules, oral liquids, and ointments, the capsules produced by this invention have a simpler administration method, easier dosage control, more stable drug content, solve the palatability problem, and are simple to process, easy to operate, and easy to store, transport, or carry. Attached Figure Description

[0054] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments, and the advantages of the present invention in the above and / or other aspects will become clearer.

[0055] Figure 1 The effects of traditional Chinese medicine formulations on oral inflammation in cats.

[0056] Figure 2 This is a graph showing the changes in the cat's food intake before and after treatment. Detailed Implementation

[0057] The present invention is described in detail below with reference to specific embodiments. However, it should be noted that the scope of protection of the present invention is not limited by these specific embodiments and principle explanations, but is determined by the claims.

[0058] Unless otherwise specified, the experimental methods described in the following examples are conventional methods; unless otherwise specified, the reagents and materials are commercially available.

[0059] In this invention, except where expressly stated, any matters or issues not mentioned herein are directly applicable to those known in the art without any modification. Furthermore, any implementation described herein can be freely combined with one or more other implementations described herein, and the resulting technical solutions or concepts are considered part of the original disclosure or original record of this invention, and should not be regarded as new content not disclosed or anticipated herein, unless those skilled in the art consider the combination clearly unreasonable.

[0060] All features disclosed in this invention can be combined arbitrarily, and such combinations should be understood as the contents disclosed or recorded in this invention, unless those skilled in the art consider such combinations to be obviously unreasonable.

[0061] The numerical points disclosed in this specification include not only the numerical points specifically disclosed in the embodiments, but also the endpoints of each numerical range in the specification. Any combination of these numerical points should be regarded as the range disclosed or recorded in this invention.

[0062] In this invention, the technical and scientific terms that are given a definition shall be used as defined thereon, and those that are not given a definition shall be understood according to their common meaning in the art.

[0063] Guided by traditional Chinese veterinary medicine theory, this invention formulates Chinese herbal medicines based on the properties, flavors, and relationships between herbs, as well as the characteristics of feline stomatitis. The formulas are then extracted, dried, and made into capsules, and their effects are measured.

[0064] Example 1: Preparation of Traditional Chinese Medicine Formula Capsules

[0065] Prescription: 10 parts licorice root, 7 parts honeysuckle, 7 parts ophiopogon japonicus, 6 parts peony bark, 6 parts scutellaria baicalensis, 6 parts coptis chinensis, 6 parts codonopsis pilosula, and 6 parts jujube.

[0066] The Chinese herbs are mixed according to the prescription ratio, pulverized using a grinder, and passed through a 10-mesh sieve. 100g of powder is accurately weighed, and 10 times its weight of deionized water is added. After soaking for 30 minutes, the mixture is brought to a rapid boil over high heat, then simmered for another 30 minutes. The decoction is filtered out. Another 10 times its weight of deionized water is added to the filtered residue, and the decoction is repeated. The two decoction filtrates are combined, allowed to settle for 60 minutes, and filtered twice to remove impurities. All filtrates are then concentrated in a 50℃ rotary evaporator until 1ml of the concentrate equals 3g of the original herbs. The concentrated liquid is then dried to obtain the spray-dried powder of the Chinese herbal formula. 20% starch is added to the spray-dried powder, and the mixture is then filled into capsules using an automatic capsule filling machine.

[0067] The traditional Chinese medicine capsules for the prevention and treatment of feline stomatitis prepared by this invention contain 150mg of raw herbs per capsule.

[0068] Example 2: Treatment of feline stomatitis with a traditional Chinese medicine formula

[0069] The experimental animals were cats with naturally occurring stomatitis from September to October 2023 in Jiangning District, Nanjing City. Suitable cases for treatment were selected from all affected cats according to established criteria. Data from 15 confirmed cases of cat stomatitis were collected. These 15 selected cats with naturally occurring stomatitis were orally administered two capsules of a prepared traditional Chinese medicine formulation once daily for a total of 7 days.

[0070] 1. Observation and scoring of cat's oral health

[0071] Observe the cat's oral condition before and after treatment, take photos and record the data, and score the cat's oral condition according to the feline chronic gingivostomatitis (CGS) scale.

[0072] Table 2. Feline Chronic Gingivostomatitis (CGS) Scale

[0073]

[0074] 2. Observation of cat's food intake and weight

[0075] Observe the cat's appetite and pain response during eating, and record the daily food intake and weight changes.

[0076] 3. The effect of traditional Chinese medicine prescriptions on the oral health scores of cats

[0077] The effects of the traditional Chinese medicine (TCM) formula on the oral health scores of cats are shown in Table 3. After treatment with the TCM formula, the oral health scores of the cats decreased to varying degrees, and the oral symptoms were alleviated and recovered to varying degrees. Specifically, the pain score, oral inflammation score, and appetite score decreased significantly (P<0.01), as did the halitosis score and submandibular lymph node score (P<0.05), and the overall oral health score decreased significantly (P<0.01). These results indicate that the TCM formula can significantly alleviate the pain, oral inflammation, and halitosis symptoms in cats with stomatitis, reduce the degree of submandibular lymph node swelling, and improve the appetite of the cats, thus having a certain therapeutic effect on feline stomatitis.

[0078] Table 3. Effects of Traditional Chinese Medicine Formulas on Oral Health Scores in Cats (n=15)

[0079]

[0080] Note: *P<0.05, **P<0.01 (comparison between before and after treatment)

[0081] 4. The effect of traditional Chinese medicine formulas on the oral health of cats

[0082] Figure 1 This is a comparison of the cat's oral condition before and after treatment. It is clear that the traditional Chinese medicine formula significantly alleviated the cat's oral inflammation; the redness and swelling in the affected area lessened, the ulcers shrank, and the pain response to touch decreased. While the treatment did not significantly alleviate the oral inflammation in the other cats, it did significantly relieve their pain.

[0083] 5. The effect of traditional Chinese medicine prescriptions on cat weight

[0084] The effect of the traditional Chinese medicine formula on the weight of the cats is shown in Table 4. After treatment with the traditional Chinese medicine formula, the weight of the cats increased significantly (P<0.01). This result may be due to the traditional Chinese medicine formula reducing pain, increasing appetite, and increasing food intake in cats with stomatitis. This result indicates that the traditional Chinese medicine formula can significantly increase the weight of the cats and improve their physical condition.

[0085] Table 4. Effects of Traditional Chinese Medicine Formulas on Cat Weight (n=15)

[0086]

[0087] Note: *P<0.05, **P<0.01 (comparison between before treatment and 7 days after treatment).

[0088] 6. The effect of traditional Chinese medicine prescriptions on cats' food intake

[0089] like Figure 2 As shown in Table 5, the cats' food intake significantly increased after treatment with the traditional Chinese medicine formula (P<0.01). Before treatment, the cats had no appetite and were unwilling to eat. After treatment, their appetite increased significantly, and they were able to eat both dry and wet foods. Before treatment, each cat suffered from loss of appetite or even complete aversion to food due to pain from oral inflammation. They exhibited behaviors such as screaming, pain, and frequent head shaking while eating, indicating severe oral pain. After 7 days of treatment with the traditional Chinese medicine formula, the cats' appetite increased significantly, the pain during eating decreased, the pain level decreased, the food intake increased, and their overall mental state improved compared to before treatment.

[0090] Table 5. Effects of Traditional Chinese Medicine Formulas on Food Intake in Cats (n=15)

[0091]

[0092] Note: *P<0.05, **P<0.01 (comparison between before treatment and 7 days after treatment)

[0093] The results of this case study indicate that the traditional Chinese medicine capsule formulation is effective for feline stomatitis, significantly reducing the oral condition score of feline stomatitis, increasing the cat's food intake and weight, effectively alleviating oral pain in cats with stomatitis, and also having a certain effect on relieving oral inflammation in cats.

[0094] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.

Claims

1. A traditional Chinese medicine composition for the prevention and treatment of feline stomatitis, characterized in that, It is made from the following raw materials in parts by weight: licorice 2-20 parts, honeysuckle 4-10 parts, ophiopogon japonicus 4-10 parts, peony bark 4-8 ​​parts, scutellaria baicalensis 4-8 parts, coptis chinensis 4-8 parts, codonopsis pilosula 4-8 parts, and jujube 4-8 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The weight proportions of each raw material are as follows: licorice 5-15 parts, honeysuckle 6-8 parts, ophiopogon japonicus 6-8 parts, peony bark 5-7 parts, scutellaria baicalensis 5-7 parts, coptis chinensis 5-7 parts, codonopsis pilosula 5-7 parts, and jujube 5-7 parts.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The weight proportions of each raw material are as follows: licorice 10 parts, honeysuckle 7 parts, ophiopogon japonicus 7 parts, peony bark 6 parts, scutellaria baicalensis 6 parts, coptis chinensis 6 parts, codonopsis pilosula 6 parts, and jujube 6 parts.

4. A traditional Chinese medicine extract for the prevention and treatment of feline stomatitis, characterized in that, It is made from the following raw materials in parts by weight: licorice 2-20 parts, honeysuckle 4-10 parts, ophiopogon japonicus 4-10 parts, peony bark 4-8 ​​parts, scutellaria baicalensis 4-8 parts, coptis chinensis 4-8 parts, codonopsis pilosula 4-8 parts, and jujube 4-8 parts.

5. The traditional Chinese medicine extract according to claim 4, characterized in that, The weight proportions of each raw material are as follows: licorice 5-15 parts, honeysuckle 6-8 parts, ophiopogon japonicus 6-8 parts, peony bark 5-7 parts, scutellaria baicalensis 5-7 parts, coptis chinensis 5-7 parts, codonopsis pilosula 5-7 parts, and jujube 5-7 parts.

6. The traditional Chinese medicine extract according to claim 4, characterized in that, The weight proportions of each raw material are as follows: licorice 10 parts, honeysuckle 7 parts, ophiopogon japonicus 7 parts, peony bark 6 parts, scutellaria baicalensis 6 parts, coptis chinensis 6 parts, codonopsis pilosula 6 parts, and jujube 6 parts.

7. A traditional Chinese medicine preparation for the prevention and treatment of feline stomatitis, characterized in that, It is made from (i) the product obtained by extraction and drying of the traditional Chinese medicine composition according to any one of claims 1-3, and (ii) pharmaceutically acceptable excipients or carriers.

8. A traditional Chinese medicine preparation for the prevention and treatment of feline stomatitis, characterized in that, It is made from (i) the herbal extract as described in any one of claims 4-6, and (ii) a pharmaceutically acceptable excipient or carrier.

9. The traditional Chinese medicine preparation according to claim 7 or 8, characterized in that, The pharmaceutically acceptable excipient or carrier is starch.

10. The traditional Chinese medicine preparation according to claim 7 or 8, characterized in that, The dosage form of the traditional Chinese medicine preparation is capsules.

11. The method for preparing the traditional Chinese medicine extract according to any one of claims 4-6, characterized in that: Weigh each raw material according to the specified weight proportions, soak in water, decoct, concentrate, filter, and spray dry for later use.

12. The preparation method according to claim 11, characterized in that, The water mass is 5-15 times the total mass of all raw materials; the soaking time is 10-60 minutes; the decoction time is 10-50 minutes per decoction, and the decoction is performed 1-3 times in total.

13. The use of the traditional Chinese medicine composition according to any one of claims 1-3, the traditional Chinese medicine extract according to any one of claims 4-6, or the traditional Chinese medicine preparation according to any one of claims 7-8 in the preparation of a medicine for the prevention and treatment of feline stomatitis.

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