Chinese herbal composition for treating long covid syndrome related brain fog and preparation method and application thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, and specifically discloses a Chinese herbal medicine composition for treating long-COVID syndrome related brain fog as well as a preparation method and application thereof. The Chinese herbal medicine composition comprises the following components in parts by weight: 15-30 parts of radix puerariae, 15-20 parts of ligusticum chuanxiong, 15-20 parts of semen astragali complanati, 10-20 parts of fructus crataegi, 6-9 parts of semen raphani, 6-9 parts of curcuma longa, 10-15 parts of radix astragali, 15-20 parts of epipactis, 10-12 parts of radix angelicae, 20-30 parts of radix paeoniae alba, 6-9 parts of radix bupleuri, 15-30 parts of cortex albiziae, 10-15 parts of rhizoma cyperi, 15-20 parts of gastrodia elata, 15-30 parts of herba potentillae, 10-12 parts of eupolyphaga, 12-15 parts of rhodiola rosea, 15-20 parts of haematitum, and 15-20 parts of radix isatidis. The drugs are used in combination, synergistically, to jointly play the roles of nourishing blood, regulating qi, resolving phlegm and blood stasis, soothing liver and relieving depression, and refreshing spirit and calming brain. The composition has the advantages of precision in prescription, definite curative effect, simplicity, low cost and high efficiency. Clinical observation shows that the composition has a good therapeutic effect on long-COVID syndrome related brain fog such as dizziness, headache, insomnia, tinnitus and memory decline, and is expected to be clinically popularized and applied.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and specifically to a traditional Chinese medicine composition for treating cerebral fog associated with chronic COVID-19 syndrome, its preparation method, and its application. Background Technology

[0002] Long-term symptoms of COVID-19, also known as post-COVID-19 sequelae, typically occur within three months of the onset of infection. These can be new symptoms appearing after recovery from an acute infection, or persistent symptoms from the initial acute infection. Symptoms last at least two months, can recur, and cannot be explained by other diagnoses. COVID-19 patients may experience cognitive difficulties during recovery, including problems with attention, memory, information processing, planning, and organization. The *Journal of the American Medical Association* also published reports of patients experiencing "brain fog" lasting up to eight months after COVID-19 infection. "Brain fog" is actually used to describe a complex set of symptoms. Among the many symptoms of "long-term COVID-19," brain fog is the most discussed neurological issue.

[0003] Brain fog, also known as brain haze, is a specific type of consciousness disorder characterized by a general feeling of mental cloudiness, including a mild decrease in arousal or level of consciousness, and a decline in attention and perception of time and the surrounding environment. Brain fog causes mental confusion and a decline in cognitive abilities, including memory, language comprehension and use, information processing, visuospatial awareness, calculation, problem-solving, and executive functions. Common symptoms of brain fog include dizziness, headache, insomnia, tinnitus, poor concentration, abnormal thought processes, and impaired comprehension and language expression. It can also cause confusion, indecisiveness, and decreased self-confidence in patients. Current research suggests that brain fog formation may be related to the release of inflammatory factors in the brain and impaired cerebral blood flow. Mental stimulation and postural reflexes can cause abnormal vasoconstriction in peripheral blood vessels, leading to insufficient blood supply to the functional areas of the cerebral cortex; anemia reduces the oxygen-carrying capacity of red blood cells, causing neuronal metabolic disorders; stressful environments and neurodegenerative diseases can cause local inflammation in the brain; dysfunction of the immune regulation function of mast cells in the brain can alter the permeability of the blood-brain barrier and brain function; abnormalities in important neurotransmitters in the brain, such as histamine levels, can affect brain metabolism and the role of inflammatory factors. These are all possible pathological mechanisms of brain fog.

[0004] While most cases of brain fog are not life-threatening, they can significantly impact an individual's mental state, thereby affecting daily life and work. Therefore, taking effective measures to improve brain fog symptoms is essential. Overcoming brain fog and improving symptoms first requires eliminating the triggering factors and improving lifestyle, with medication considered when necessary. Lifestyle improvements include maintaining a comfortable working and living environment, a healthy and balanced diet, actively participating in social activities, and engaging in physical exercise. If an underlying disease exists, it should be actively treated, such as relieving pain and controlling inflammation, while avoiding the effects of medications. Furthermore, ensuring sufficient sleep is also crucial for mitigating the impact of brain fog. If these methods fail to improve brain fog symptoms, medication or other treatments may be necessary. Currently, modern medicine lacks effective treatments for brain fog.

[0005] Patent application CN115487233A discloses a Chinese herbal composition for improving symptoms of cerebral fog, prepared from kelp, hawthorn, lotus leaf, kudzu root, and mulberry. While it possesses certain effects in promoting blood circulation, resolving phlegm, and tonifying the liver and kidneys, its effects are relatively weak, and it does not address the complex pathogenesis of cerebral fog symptoms or propose a targeted treatment plan. Summary of the Invention

[0006] This invention provides a traditional Chinese medicine composition for treating cerebral fog associated with chronic COVID-19 syndrome, its preparation method, and its application. Through the treatment methods of nourishing blood and regulating qi, resolving phlegm and dispersing blood stasis, soothing the liver and relieving depression, refreshing the mind and calming the brain, and dispelling wind and relieving pain, it can effectively treat cerebral fog symptoms associated with chronic COVID-19 syndrome.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: a traditional Chinese medicine composition for treating cerebral fog associated with COVID-19 syndrome, comprising the following components by weight: 15-30 parts of Pueraria lobata, 15-20 parts of Ligusticum chuanxiong, 15-20 parts of Hedyotis diffusa, 10-20 parts of Crataegus pinnatifida, 6-9 parts of Sinapis alba, 6-9 parts of Curcuma longa, 10-15 parts of Astragalus membranaceus, 15-20 parts of Pyrola rotundifolia, 10-12 parts of Angelica dahurica, 20-30 parts of Paeonia lactiflora, 6-9 parts of Bupleurum chinense, 15-30 parts of Albizia julibrissin bark, 10-15 parts of Cyperus rotundus, 15-20 parts of Gastrodia elata, 15-30 parts of Agrimonia pilosa, 10-12 parts of Eupolyphaga sinensis, 12-15 parts of Rhodiola rosea, 15-20 parts of Hematite, and 15-20 parts of Indigofera tinctoria.

[0008] Furthermore, the formula includes 30 parts of kudzu root, 15 parts of chuanxiong rhizome, 15 parts of rockwort, 10 parts of hawthorn, 6 parts of white mustard seed, 6 parts of turmeric, 15 parts of astragalus root, 15 parts of deer antler grass, 10 parts of angelica root, 20 parts of white peony root, 6 parts of bupleurum root, 30 parts of albizia bark, 10 parts of cyperus rhizome, 15 parts of gastrodia rhizome, 20 parts of agrimony, 10 parts of ground beetle, 15 parts of rhodiola rosea, 15 parts of hematite, and 15 parts of indigo naturalis.

[0009] This invention also relates to a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps:

[0010] Weigh each ingredient according to the formula, soak it in water, then heat and boil it, filter and collect the decoction, and finally concentrate the decoction to obtain the final product.

[0011] Furthermore, the amount of water added is three times the mass of the raw material components; the decoction time is 20-30 minutes, and it is concentrated into a decoction.

[0012] Furthermore, the amount of water added is 5 to 6 times the mass of the raw material components; the decoction time is 30 to 40 minutes; after filtration, the residue is added with 2 to 3 times the amount of water and decocted for another 30 to 40 minutes; after filtration, the decoctions are combined and concentrated to prepare a pharmaceutically acceptable dosage form.

[0013] Furthermore, the dosage forms include, but are not limited to, tablets, pills, powders, capsules, or granules.

[0014] This invention also relates to the application of the aforementioned traditional Chinese medicine composition in the preparation of a drug for treating cerebral fog associated with chronic COVID-19 syndrome.

[0015] The present invention has the following beneficial effects:

[0016] The herbal composition of this invention is based on the principles of nourishing blood and regulating qi, resolving phlegm and dispersing blood stasis, soothing the liver and relieving depression, and refreshing the mind and calming the brain. Among them, Astragalus membranaceus, Agrimonia pilosa, and Indigofera tinctoria nourish blood and regulate qi; Bupleurum chinense soothes the liver and relieves depression; Albizia julibrissin bark refreshes the mind and calms the brain; Hedyotis diffusa, Ligusticum chuanxiong, Eupolyphaga sinensis, Rhodiola rosea, Pueraria lobata, Pyrola rotundifolia, Curcuma longa invigorates blood and removes blood stasis; Crataegus pinnatifida and Sinapis alba resolve phlegm and reduce turbidity; Angelica dahurica and Cyperus rotundus dispel wind and relieve pain; Paeonia lactiflora nourishes blood and astringes yin; Gastrodia elata and Hematite calm wind and stop spasms, and suppress liver yang. The combined effects of these herbs are synergistic, achieving the combined effects of nourishing blood and regulating qi, resolving phlegm and dispersing blood stasis, soothing the liver and relieving depression, refreshing the mind and calming the brain, and dispelling wind and relieving pain. The above-mentioned herbal composition has the advantages of scientific and precise formulation, stable efficacy, syndrome differentiation and prescription, and clear mechanism, and has good therapeutic effects, making it promising for clinical application. Detailed Implementation

[0017] This invention provides a traditional Chinese medicine composition for treating cerebral fog associated with chronic COVID-19 syndrome, comprising the following components by weight: 15-30 parts of Pueraria lobata, 15-20 parts of Ligusticum chuanxiong, 15-20 parts of Hedyotis diffusa, 10-20 parts of Crataegus pinnatifida, 6-9 parts of Sinapis alba, 6-9 parts of Curcuma longa, 10-15 parts of Astragalus membranaceus, 15-20 parts of Pyrola rotundifolia, 10-12 parts of Angelica dahurica, 20-30 parts of Paeonia lactiflora, 6-9 parts of Bupleurum chinense, 15-30 parts of Albizia julibrissin bark, 10-15 parts of Cyperus rotundus, 15-20 parts of Gastrodia elata, 15-30 parts of Agrimonia pilosa, 10-12 parts of Eupolyphaga sinensis, 12-15 parts of Rhodiola rosea, 15-20 parts of Hematite, and 15-20 parts of Indigofera tinctoria.

[0018] The ingredients include, but are not limited to, 15, 18, 20, 22, 25, 27, or 30 parts of kudzu root; 15, 16.5, 18, 19, or 20 parts of chuanxiong rhizome; 15, 16, 17, 18.6, or 20 parts of *Hemiptera japonica* rhizome; 10, 12, 15, 18.9, or 20 parts of hawthorn fruit; 6, 7, 8, or 9 parts of white mustard seed; 6, 7, 8, or 9 parts of turmeric; 10, 11.5, 12.6, 13.8, 14.2, or 15 parts of astragalus root; 15, 17, 19.9, or 20 parts of *Pyrola rotundifolia* rhizome; 10, 11.4, or 12 parts of angelica dahurica root; and 20 or 22 parts of white peony root. 25, 29, or 30 parts; Bupleurum chinense, including but not limited to 6, 6.1, 6.3, 7, 8.2, or 9 parts; Albizia julibrissin bark, including but not limited to 15, 17, 19, 24, 25.6, 27.9, or 30 parts; Cyperus rotundus, including but not limited to 10, 12, 13, or 15 parts; Gastrodia elata, including but not limited to 15, 16, 17, 18, 19, or 20 parts; Agrimonia pilosa, including but not limited to 15, 17, 19, 22, 25, 28, or 30 parts; Eupolyphaga sinensis, including but not limited to 10, 11, or 12 parts; Rhodiola rosea, including but not limited to 12, 14, or 15 parts; Hematite, including but not limited to 15, 17, 19, or 20 parts; Indigofera tinctoria, including but not limited to 15, 17, 18.5, 19.5, or 20 parts.

[0019] In a more preferred formulation, the ingredients are: 30 parts kudzu root, 15 parts chuanxiong rhizome, 15 parts rock hemp root, 10 parts hawthorn fruit, 6 parts white mustard seed, 6 parts turmeric, 15 parts astragalus root, 15 parts deer antler grass, 10 parts angelica root, 20 parts white peony root, 6 parts bupleurum root, 30 parts albizia bark, 10 parts cyperus rhizome, 15 parts gastrodia rhizome, 20 parts agrimony, 10 parts ground beetle, 15 parts rhodiola rosea, 15 parts hematite, and 15 parts indigo naturalis.

[0020] This invention also relates to the preparation of the aforementioned herbal composition into decoctions, tablets, pills, powders, capsules, granules, etc. Specific preparation methods are as follows:

[0021] 1. Preparation of the decoction: Take kudzu root, chuanxiong rhizome, *Hemiberlesia lingua* root, hawthorn fruit, white mustard seed, turmeric, astragalus root, *Pyrola rotundifolia* herb, angelica root, white peony root, bupleurum root, albizia bark, cyperus rhizome, gastrodia rhizome, agrimony, ground beetle, rhodiola rosea root, hematite, and indigo naturalis. First, soak the ingredients in three times their total volume of water. Then, bring to a boil over high heat, followed by simmering over low heat for 20-30 minutes, concentrating the decoction to two-thirds of its original volume. For oral administration, take 200-250 mL three times daily.

[0022] 2. Tablet Preparation: Take kudzu root, chuanxiong rhizome, *Hemiberlesia lingua* root, hawthorn fruit, white mustard seed, turmeric, astragalus root, *Pyrola rotundifolia* herb, angelica root, white peony root, bupleurum root, albizia bark, cyperus rhizome, gastrodia rhizome, agrimony, ground beetle, rhodiola rosea root, hematite, and indigo naturalis. First, soak the ingredients in 5-6 times their total volume of water, then decoct for 30-40 minutes, filter to obtain the decoction; add 2-3 times their total volume of water to the residue and decoct for another 30-40 minutes, combine the decoctions, filter and concentrate to an appropriate amount; add an appropriate amount of starch or dextrin, mix well, granulate, dry, sizing, compress, coat, and package to obtain tablets.

[0023] 3. Preparation of pills: Take kudzu root, chuanxiong rhizome, rock hedyotis diffusa, hawthorn, white mustard seed, turmeric, astragalus root, deer antler grass, angelica root, white peony root, bupleurum root, albizia bark, cyperus rhizome, gastrodia rhizome, agrimony, ground beetle, rhodiola rosea, hematite, and indigo naturalis. First, soak the ingredients in 5-6 times their total volume of water, then decoct for 30-40 minutes, and filter to obtain the decoction; add 2-3 times their total volume of water to the residue and decoct for another 30-40 minutes, then combine the two decoctions, filter and concentrate to an appropriate amount; add an appropriate amount of starch or dextrin, mix well; form into pills using a mechanical pill-making machine, dry, coat with black iron oxide, talc powder and an appropriate amount of binder, and dry to make pills.

[0024] 4. Preparation of the powder: Take kudzu root, chuanxiong rhizome, rock hemp root, hawthorn fruit, white mustard seed, turmeric, astragalus root, deer antler grass, angelica root, white peony root, bupleurum root, albizia bark, cyperus rhizome, gastrodia rhizome, agrimony, ground beetle, rhodiola rosea root, hematite, and indigo naturalis. First, soak the raw materials in 5-6 times their total volume of water, then decoct for 30-40 minutes, and filter to obtain the decoction; add 2-3 times their total volume of water to the residue and decoct for another 30-40 minutes, then combine the two decoctions, filter and concentrate to an appropriate amount; add an appropriate amount of starch or dextrin, mix well, dry, and pulverize into a fine powder to make the powder.

[0025] 5. Preparation of Capsules: Take kudzu root, chuanxiong rhizome, *Hemiberlesia lingua* root, hawthorn fruit, white mustard seed, turmeric, astragalus root, *Pyrola rotundifolia* herb, angelica root, white peony root, bupleurum root, albizia bark, cyperus rhizome, gastrodia rhizome, agrimony, ground beetle, rhodiola rosea, hematite, and indigo naturalis. First, soak the ingredients in 5-6 times their total volume of water, then decoct for 30-40 minutes, and filter to obtain the decoction. Add 2-3 times their total volume of water to the residue and decoct for another 30-40 minutes. Combine the two decoctions, filter, and concentrate to an appropriate amount. Add an appropriate amount of starch or dextrin, mix well, granulate, fill, and prepare capsules.

[0026] 6. Preparation of Granules: Take kudzu root, chuanxiong rhizome, *Hemiberlesia lingua* root, hawthorn fruit, white mustard seed, turmeric, astragalus root, *Pyrola rotundifolia* herb, angelica root, white peony root, bupleurum root, albizia bark, cyperus rhizome, gastrodia rhizome, agrimony, ground beetle, rhodiola rosea root, hematite, and indigo naturalis. First, soak the ingredients in 5-6 times their total volume of water, then decoct for 30-40 minutes, and filter to obtain the decoction. Add 2-3 times their total volume of water to the residue and decoct for another 30-40 minutes. Combine the two decoctions, filter, and concentrate to an appropriate amount. Add an appropriate amount of starch or dextrin, mix well, and granulate.

[0027] The above-mentioned type 2-6 preparations are taken in doses of 3-5g each time, once in the morning, noon and evening.

[0028] The properties, flavors, meridian tropisms, and therapeutic effects of the components in the raw medicinal materials selected for this invention are as follows:

[0029] Kudzu root: The dried root of *Pueraria lobata* or *Pueraria truncata*, both belonging to the legume family. The former is commonly known as "wild kudzu," and the latter as "powdered kudzu." Wild kudzu is mainly produced in Henan, Sichuan, and Zhejiang provinces, while powdered kudzu is mainly produced in Guangxi and Guangdong provinces. It is harvested in autumn and winter. After being cut into thick slices or small sections and dried, it can be used raw or simmered. It is sweet, pungent, and cool in nature, and enters the spleen, stomach, and lung meridians. This herb can promote blood circulation and is often used in modern times in combination with *Panax notoginseng* and *Salvia miltiorrhiza* to treat hemiplegia due to stroke, chest pain, and stiff neck and neck due to hypertension. In addition, it can also treat external pathogenic factors, stiff neck and back pain, incomplete measles eruption, thirst due to fever, thirst due to yin deficiency, dysentery due to damp heat, and diarrhea due to spleen deficiency.

[0030] Chuanxiong (Ligusticum striatum): The dried rhizome of Ligusticum striatum, a plant in the Apiaceae family. It is mainly produced in Sichuan, Guizhou, and Yunnan provinces, with the Sichuan variety considered to be of superior quality. It is harvested in summer and used raw or processed with wine. It is pungent and warm in nature, and enters the liver, gallbladder, and pericardium meridians. It has the effects of promoting blood circulation, regulating qi, dispelling wind, and relieving pain. It is commonly used to treat headaches, rheumatic pain, and various pain syndromes caused by blood stasis and qi stagnation.

[0031] *Salvia miltiorrhiza* (also known as *Salvia miltiorrhiza* var. *sharpium*), an annual herb belonging to the Lamiaceae family. It is bitter and pungent in taste, and neutral in nature. Its functions include promoting blood circulation, removing blood stasis, detoxifying, and dispersing nodules. It is primarily used to treat dysphagia, phlegm-induced asthma, unexplained swelling and pain, scrofula, hepatitis, and leukorrhea.

[0032] Hawthorn: The dried, ripe fruit of *Crataegus pinnatifida* or *Crataegus cuneata*, both belonging to the Rosaceae family. It is mainly produced in Henan, Shandong, and Hebei provinces. Harvested in autumn when the fruit is ripe, it can be used raw or stir-fried. It is sour, sweet, and slightly warm in nature, and enters the spleen, stomach, and liver meridians. It has the effects of dispelling dampness and stagnation, promoting qi circulation and dispersing blood stasis. It is commonly used to treat food stagnation, diarrhea, abdominal pain, and blood stasis syndromes. In modern times, raw hawthorn is used to treat hyperlipidemia, hypertension, and coronary heart disease, with good results.

[0033] White mustard seed: The dried, mature seed of the white mustard plant (Sinapis alba), a member of the Brassicaceae family. It is mainly produced in Anhui, Henan, and Sichuan provinces. The whole plant is harvested in late summer and early autumn when the fruit is ripe, and used raw or stir-fried. It is pungent and warm in nature, and enters the lung and stomach meridians. It has the effects of warming the lungs and resolving phlegm, promoting qi circulation and dispersing stagnation, and unblocking the meridians and relieving pain. It is often used for cough with cold phlegm, pleural effusion, yin-type carbuncles, numbness of limbs, and swelling and pain of joints.

[0034] Turmeric: The dried rhizome of the turmeric plant (Zingiberaceae family). Mainly produced in Zhejiang, Sichuan, and Fujian provinces, with the Zhejiang variety considered the authentic medicinal material. Harvested in winter and sliced ​​thickly for raw use. It is pungent, bitter, and warm in nature, and enters the liver and spleen meridians. It has the effects of promoting blood circulation, regulating qi, and relieving pain. It is commonly used to treat various pains caused by blood stasis and qi stagnation, as well as rheumatic shoulder and arm pain.

[0035] Astragalus: The dried root of *Astragalus mongholicus* or *Astragalus membranaceus*, both belonging to the legume family. It is mainly produced in Inner Mongolia, Shanxi, and Gansu. Harvested in spring and autumn. Used raw or honey-processed. It is sweet and slightly warm in nature, and enters the spleen and lung meridians. It has the effects of tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, generating fluids and nourishing blood, promoting circulation and relieving pain, and promoting tissue regeneration and detoxification.

[0036] *Pyrola rotundifolia*, the whole herb of the plant *Pyrola rotundifolia*, belonging to the Pyrolaceae family. It grows in shady and damp places in valleys, streams, or under forests. It is produced in Northeast China, Hebei, Henan, Jiangsu, and other regions. It can be harvested year-round. After removing impurities, it is sun-dried until the leaves are relatively soft, then piled up until the leaves turn purplish-brown, and finally sun-dried again. Some are directly sun-dried, but this makes them hard and brittle. It is warm in nature and has a sweet and bitter taste. It enters the liver and kidney meridians. It dispels wind and dampness, strengthens tendons and bones, invigorates blood circulation and regulates menstruation, stops bleeding, and relieves cough. It is used to treat rheumatic pain, weakness of the waist and knees, insomnia, menorrhagia, hematemesis, epistaxis, chronic cough, metrorrhagia, leukorrhea, and traumatic bleeding. Modern pharmacological studies have shown that it has anti-inflammatory, vasodilatory, cardiac contractility-enhancing, hypotensive, and antibacterial effects.

[0037] Angelica dahurica: The dried root of Angelica dahurica or Angelica dahurica var. hainanensis, belonging to the Apiaceae family. Mainly produced in Zhejiang, Henan, Hebei, and other regions. Harvested in summer and autumn when the leaves turn yellow, then sun-dried or dried at low temperature. Sliced ​​into thick pieces and used raw. It is pungent and warm in nature, and enters the lung, stomach, and large intestine meridians. It has the effects of relieving exterior syndromes and dispelling cold, dispelling wind and relieving pain, clearing nasal passages, drying dampness and stopping leukorrhea, reducing swelling and draining pus. It is commonly used to treat exterior syndromes due to wind-cold, headache, supraorbital neuralgia, toothache, rheumatic pain, epistaxis, nasal congestion and runny nose, leukorrhea, and sores and swelling.

[0038] White peony root: It is the dried root of the peony plant (Paeonia lactiflora), belonging to the Ranunculaceae family. It is mainly produced in Zhejiang, Anhui, and Sichuan provinces. It is harvested in summer and autumn. It is generally used raw, or stir-fried or processed with wine. It is bitter, sour, and slightly cold in nature, and enters the liver and spleen meridians. It nourishes blood and regulates menstruation, softens the liver and relieves pain, calms liver yang, and astringes yin to stop sweating. It is commonly used for liver blood deficiency, irregular menstruation, liver-spleen disharmony, chest, rib, and abdominal pain, limb spasms and pain, liver yang hyperactivity, headache, dizziness, spontaneous sweating, and night sweats.

[0039] Bupleurum: The dried root of either Bupleurum chinense (Northern Bupleurum) or Bupleurum stenoptera (Southern Bupleurum), both belonging to the Apiaceae family. The former, commonly known as "Northern Bupleurum," is produced in Liaoning, Hebei, and Henan provinces; the latter, commonly known as "Southern Bupleurum," is mainly produced in Hubei, Sichuan, and Anhui provinces. Harvested in spring and autumn, then dried. Cut into sections. Used raw or processed with vinegar. It is pungent, bitter, and slightly cold in nature. It enters the liver, gallbladder, and lung meridians. It has the effects of dispersing and reducing fever, soothing the liver and relieving depression, and raising yang qi. It is commonly used to treat fever due to external pathogens, Shaoyang syndrome, liver qi stagnation, and sinking of middle qi.

[0040] Albizia bark: The dried bark of the Albizia julibrissin tree, a legume. It is distributed throughout most of China, mainly produced in the provinces along the Yangtze River. The bark is harvested in summer and autumn and used raw. It is sweet and neutral in nature. It enters the heart, liver, and lung meridians. It has the effects of relieving depression and calming the mind, promoting blood circulation and reducing swelling. It is commonly used to treat restlessness, depression and insomnia, traumatic injuries, blood stasis and swelling, lung abscess, and carbuncles and boils.

[0041] Cyperus rotundus: The dried rhizome of Cyperus rotundus, a plant in the Cyperaceae family. Widely distributed and abundant in China, it is mainly produced in Guangdong, Henan, and Sichuan provinces. Harvested in autumn, the fibrous hairs are singed off. It is then briefly boiled or steamed in boiling water before sun-drying, or singed and then directly sun-dried. It can be used raw or stir-fried with vinegar. It is pungent, slightly bitter, slightly sweet, and neutral in nature, and enters the lung, spleen, and triple burner meridians. It has the effects of soothing the liver and relieving depression, regulating qi and relieving chest tightness, regulating menstruation and relieving pain. It is commonly used to treat hypochondriac pain and abdominal pain due to liver qi stagnation, abdominal pain due to spleen and stomach qi stagnation, dysmenorrhea due to irregular menstruation, and breast distension and pain.

[0042] Gastrodia elata: The dried tuber of Gastrodia elata, an orchid. Mainly produced in Sichuan, Yunnan, and Guizhou provinces. Harvested from the beginning of autumn to before the Qingming Festival of the following year; tubers harvested when the stems wither in winter are called "winter tubers" and are of higher quality; tubers harvested when they sprout in spring are called "spring tubers" and are of lower quality. Sliced ​​thinly and used raw. It is sweet and neutral in nature, and enters the liver meridian. It has the effects of calming wind and stopping spasms, suppressing liver yang, and dispelling wind and unblocking the meridians. It is commonly used to treat internal liver wind, epilepsy and convulsions, dizziness, headache, numbness of limbs, hemiplegia, and rheumatic pain.

[0043] Agrimony: The dried aerial parts of Agrimony, a plant in the Rosaceae family. Mainly produced in Zhejiang, Jiangsu, and Hubei provinces. Harvested in summer and autumn when the stems and leaves are lush. Used raw or charred. It is bitter, astringent, and neutral in nature, and enters the heart and liver meridians. It has astringent, hemostatic, anti-dysentery, anti-malarial, detoxifying, and tonifying effects. Commonly used for various bleeding disorders, bloody dysentery, malaria, vaginal itching and leukorrhea, carbuncles and boils, and fatigue and exhaustion.

[0044] Ground beetle: This product is the dried body of the female ground beetle (Eupolyphaga sinensis) or the female ground beetle (Eupolyphaga jishen), belonging to the Blattodea family. It is mainly produced in Hunan, Hubei, Jiangsu, and other regions. Wild species are caught in summer; those raised in captivity can be caught year-round. After capture, they are scalded to death in boiling water and then sun-dried or oven-dried. It can be used raw or stir-fried. It is salty and cold in nature, and slightly toxic. It enters the liver meridian. It has the effects of breaking up blood stasis, promoting blood circulation, and healing bones and tendons. It is commonly used to treat traumatic injuries, tendon injuries and fractures, amenorrhea due to blood stasis, postpartum abdominal pain due to blood stasis, and abdominal masses.

[0045] Rhodiola rosea: The dried rhizome of Rhodiola rosea, a plant in the Crassulaceae family. Mainly produced in Tibet, Sichuan, Jilin, and other regions. Harvested in autumn, dried, and used raw. It is sweet, bitter, and neutral in nature. It enters the spleen, lung, and heart meridians. It has the effects of strengthening the spleen and replenishing qi, relieving cough and asthma, and promoting blood circulation and unblocking the meridians. It is commonly used to treat spleen qi deficiency, lung yin deficiency and lung heat cough, and blood stasis. Because of its ability to promote blood circulation and remove blood stasis, it can be combined with other blood-activating and meridian-unblocking drugs to treat qi deficiency and blood stasis, chest pain, stroke paralysis, and traumatic injuries with blood stasis.

[0046] Hematite: a corundum group mineral, mainly containing ferric oxide (Fe2O3). It is primarily produced in Shanxi, Shandong, and Hebei provinces. After mining, impurities and sand are removed. It is crushed and used raw or calcined, quenched in vinegar, and ground into a coarse powder. It is bitter and cold in nature, and enters the liver, heart, lung, and stomach meridians. It has the effects of calming the liver and suppressing yang, sedating and descending rebellious qi, cooling the blood and stopping bleeding. It is commonly used to treat liver yang hyperactivity, dizziness and tinnitus, vomiting, belching, hiccups, shortness of breath, hematemesis due to blood heat, and metrorrhagia.

[0047] *Lanbuzheng*: *Lanbuzheng* is the dried whole herb of *Lanbuzheng* or *Lanbuzheng* var. *rubrum*, belonging to the Rosaceae family. It is distributed in Heilongjiang, Jilin, Liaoning, Inner Mongolia, Shanxi, Guizhou, Yunnan, Tibet, and other regions. Its leaves and stems contain carotene and tannins. The roots contain aromatic bitter substances and volatile oils, possessing the effects of invigorating qi and strengthening the spleen, nourishing blood and yin, moistening the lungs and resolving phlegm. It is commonly used for symptoms such as qi and blood deficiency, consumptive cough, and leukorrhea due to spleen deficiency. *Lanbuzheng* has a blood pressure-lowering effect and is clinically applicable for treating headaches and dizziness caused by hypertension. When combined with *Atractylodes macrocephala* and *Salvia miltiorrhiza* in a decoction, it is used for headaches and dizziness caused by hypertension.

[0048] The embodiments of the present invention will be described in detail below with reference to examples. However, those skilled in the art will understand that the following examples are only for illustrating the present invention and should not be regarded as limiting the scope of the present invention.

[0049] Example 1: 15 parts of kudzu root, 15 parts of chuanxiong rhizome, 15 parts of rockwort, 10 parts of hawthorn, 6 parts of white mustard seed, 6 parts of turmeric, 10 parts of astragalus root, 15 parts of deer antler grass, 10 parts of angelica root, 20 parts of white peony root, 6 parts of bupleurum root, 30 parts of albizia bark, 15 parts of cyperus rhizome, 15 parts of gastrodia rhizome, 15 parts of agrimony, 10 parts of ground beetle, 12 parts of rhodiola rosea, 15 parts of hematite, and 15 parts of indigo naturalis.

[0050] Example 2: 30 parts of kudzu root, 20 parts of chuanxiong rhizome, 20 parts of rockwort, 20 parts of hawthorn, 9 parts of white mustard seed, 9 parts of turmeric, 15 parts of astragalus root, 20 parts of deer antler grass, 12 parts of angelica root, 30 parts of white peony root, 9 parts of bupleurum root, 15 parts of albizia bark, 10 parts of cyperus rhizome, 15 parts of gastrodia rhizome, 15 parts of agrimony, 10 parts of ground beetle, 12 parts of rhodiola rosea, 15 parts of hematite, and 15 parts of indigo naturalis.

[0051] Example 3: 20 parts of kudzu root, 15 parts of chuanxiong rhizome, 15 parts of rockwort, 10 parts of hawthorn, 8 parts of white mustard seed, 8 parts of turmeric, 12 parts of astragalus root, 15 parts of deer antler grass, 12 parts of angelica root, 20 parts of white peony root, 6 parts of bupleurum root, 15 parts of albizia bark, 10 parts of cyperus rhizome, 18 parts of gastrodia rhizome, 30 parts of agrimony, 12 parts of ground beetle, 15 parts of rhodiola rosea, 20 parts of hematite, and 20 parts of indigo naturalis.

[0052] Example 4: 15 parts of kudzu root, 18 parts of chuanxiong rhizome, 20 parts of rockwort, 12 parts of hawthorn, 7 parts of white mustard seed, 6 parts of turmeric, 10 parts of astragalus root, 15 parts of deer antler grass, 10 parts of angelica root, 20 parts of white peony root, 6 parts of bupleurum root, 15 parts of albizia bark, 15 parts of cyperus rhizome, 20 parts of gastrodia rhizome, 20 parts of agrimony, 12 parts of ground beetle, 15 parts of rhodiola rosea, 20 parts of hematite, and 15 parts of indigo naturalis.

[0053] The above-mentioned herbal medicine combination can be used to treat brain fog associated with COVID-19 syndrome. The main clinical manifestations include dizziness, headache, insomnia, tinnitus, poor concentration, abnormal thinking process, abnormal comprehension and language expression, etc., which can cause confusion, indecisiveness and decreased self-confidence in patients with brain fog.

[0054] To better illustrate the essential features, effectiveness, and safety of the present invention, the inventors conducted a clinical observation of the treatment efficacy in 20 patients with cerebral fog associated with long-term COVID-19 syndrome.

[0055] Clinical trials

[0056] General Information

[0057] Clinical data of 20 patients with cerebral fog related to COVID-19 syndrome, collected from June 2023 to January 2024 at the Department of Neurology, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine. Clinical manifestations: dizziness in 18 cases (90%), headache in 16 cases (80%), and insomnia in 9 cases (45%).

[0058] Diagnostic criteria

[0059] The clinical diagnostic criteria for cerebral fog associated with COVID-19 syndrome are met as follows: ① Epidemiological history indicating that the patient has been infected with COVID-19 within the past year; ② Clinical manifestations of two or more symptoms, namely headache, dizziness, and insomnia, which appear or worsen after COVID-19 infection. A diagnosis is confirmed if both criteria ① and ② are met simultaneously.

[0060] Treatment

[0061] Kudzu root 15-30g, Ligusticum chuanxiong 15-20g, Hedyotis diffusa 15-20g, Crataegus pinnatifida 10-20g, Sinapis alba 6-9g, Curcuma longa 6-9g, Astragalus membranaceus 10-15g, Pyrola rotundifolia 15-20g, Angelica dahurica 10-12g, Paeonia lactiflora 20-30g, Bupleurum chinense 6-9g, Albizia julibrissin bark 15-30g, Cyperus rotundus 10-15g, Gastrodia elata 15-20g gIngredients: Agrimonia pilosa 15-30g, Eupolyphaga sinensis 10-12g, Rhodiola rosea 12-15g, Hematite 15-20g, and Indigofera tinctoria 15-20g. Soak in 1400mL of cold water for 30 minutes. Bring to a boil over high heat, then simmer over low heat for 20 minutes. Repeat this process twice. Mix the two decoctions thoroughly and divide into three doses (morning, noon, and evening), 200ml each time.

[0062] Therapeutic effect observation

[0063] 1. Treatment Results: Among all patients with cerebral fog related to COVID-19 syndrome, after 3 months and 6 months of treatment with the technology of this invention, 15 cases (75%) experienced complete elimination of symptoms such as headache, dizziness, and insomnia; the remaining 5 cases (25%) showed significant improvement in clinical symptoms. After 6 months of treatment, 2 patients experienced a recurrence of symptoms such as headache and insomnia; the remaining 18 patients showed complete disappearance of clinical symptoms, resulting in a clinical cure rate of 90%.

[0064] Table 1. Comparison of patient conditions before and after treatment

[0065]

[0066] 2. Adverse reactions: No patients experienced complications such as cerebral hemorrhage.

[0067] Because animal models of cerebral fog associated with long-term COVID-19 syndrome are difficult to establish and the success of these models is not easily assessed, further research on its mechanism of action has not yet been conducted. The following typical cases are provided to illustrate the treatment effects.

[0068] Case 1

[0069] Ms. Li, female, 36 years old, consulted on April 8, 2023. She had a 3-year history of dizziness, which often recurred. Her dizziness worsened after contracting COVID-19 in January 2023. Current symptoms: dizziness, tinnitus, headache, insomnia, loose urine, and general weakness. Her tongue was pale with a white coating, and her pulse was thready and wiry. This was diagnosed as headache, dizziness, and insomnia caused by imbalance of Qi and blood. The prescribed herbal formula of this invention was used: Pueraria lobata 90g, Ligusticum chuanxiong 90g, Hedyotis diffusa 90g, Crataegus pinnatifida 60g, Sinapis alba 45g, Curcuma longa 45g, Astragalus membranaceus 60g, Pyrola rotundifolia 90g, Angelica dahurica 60g, Paeonia lactiflora 200g, Bupleurum chinense 45g, Albizia julibrissin bark 90g, Cyperus rotundus 60g, Gastrodia elata 90g, Agrimonia pilosa 90g, Eupolyphaga sinensis 60g, Rhodiola rosea 120g, Hematite 90g, and Indigofera tinctoria 90g. The hospital pharmacy prepared 2kg of water-based pills, with a dosage of 5-6g three times daily. After six months of treatment, the symptoms almost completely disappeared. The patient was advised to maintain a light diet, and no discomfort was observed during a one-year follow-up.

[0070] Case 2

[0071] Ms. Su, female, 16 years old, had been experiencing dizziness for a year due to academic pressure. Her dizziness worsened after contracting COVID-19 in January 2023, accompanied by blurred vision, chest tightness, insomnia, and nasal congestion at night. A transcranial Doppler ultrasound revealed stenosis of the middle cerebral artery, indicating insufficient blood supply to the brain. Her tongue was pale with teeth marks on the edges, and had a white, greasy coating. Her pulse was wiry and slippery. The following herbs were prescribed: 70g of kudzu root, 90g of chuanxiong rhizome, 90g of *Hemiberlesia lingua* root, 60g of hawthorn fruit, 50g of white mustard seed, 50g of turmeric, 90g of astragalus root, 90g of *Pyrola rotundifolia* herb, 70g of angelica root, 140g of white peony root, 50g of bupleurum root, 210g of *Albizia julibrissin* bark, 70g of cyperus rhizome, 90g of gastrodia rhizome, 210g of agrimony, 70g of ground beetle, 90g of rhodiola rosea root, 90g of hematite, and 90g of *Lysimachia christinae* root. These were soaked in three times the amount of water for 20 minutes, brought to a boil over high heat, then simmered for another 20 minutes. The liquid was reduced to approximately 800ml and taken in three divided doses in the morning, noon, and evening. After taking 50 doses of this herbal medicine, the patient's dizziness and headache completely disappeared, and their appetite returned to normal.

[0072] Case 3

[0073] Ms. Liu, female, 43 years old, has a 4-year history of dizziness, with recurrent episodes. Her dizziness worsened after testing positive for COVID-19 in February 2023. Current symptoms: sudden onset of vertigo, accompanied by transient blurred vision; headache and dizziness worsen with emotional excitement. Poor appetite, normal bowel movements. Red tongue with a white, greasy coating; thready, wiry pulse. Prescription: Kudzu root 210g, Chuanxiong rhizome 140g, Hedyotis diffusa rhizome 140g, Crataegus pinnatifida fruit 210g, White mustard seed 60g, Turmeric rhizome 70g, Astragalus membranaceus 90g, Pyrola rotundifolia herb 140g, Angelica dahurica root 70g, White peony root 140g, Bupleurum chinense root 42g, Albizia julibrissin bark 90g, Cyperus rotundus rhizome 70g, Gastrodia elata rhizome 90g, Agrimonia pilosa herb 90g, Eupolyphaga sinensis herb 80g, Rhodiola rosea rhizome 80g, Hematite 90g, and Indigofera tinctoria herb 90g. Soak 12 doses of medicine in 3 times the amount of water for 20 minutes, bring to a boil over high heat, then simmer over low heat for another 20 minutes; reduce the liquid to about 800ml, and divide into three doses to be taken in the morning, noon, and evening. After taking the medicine, the dizziness and headache were significantly reduced, appetite returned to normal, and bowel movements became regular. The prescription was then changed to water-based pills according to the above proportions, and continued for another six months. The symptoms completely disappeared.

[0074] Case 4

[0075] Mr. Li, male, 35 years old, habitually enjoys spicy food and tea, often stays up late, and has suffered from dizziness for over 3 years. His dizziness worsened over the past 3 months after contracting COVID-19 in December 2022. Current symptoms: dizziness, headache, severe numbness in the back of the head, insomnia at night, daytime mental fatigue, loose stools, and bitter taste in the mouth. His tongue is pale with a white, greasy coating, and his pulse is wiry and slippery. A brain ultrasound showed "insufficient blood supply to the brain." Prescription: Kudzu root 140g, Chuanxiong rhizome 140g, Hedyotis diffusa 90g, Crataegus pinnatifida 140g, White mustard seed 60g, Turmeric 60g, Astragalus membranaceus 70g, Pyrola rotundifolia 90g, Angelica dahurica 90g, White peony root 140g, Bupleurum chinense 60g, Albizia julibrissin bark 140g, Cyperus rotundus 90g, Gastrodia elata 90g, Agrimonia pilosa 90g, Eupolyphaga sinensis 80g, Rhodiola rosea 90g, Hematite 90g, and Indigofera tinctoria 140g. 15 doses, one dose daily. Soak in 3 times the amount of water for 20 minutes, bring to a boil over high heat, then simmer over low heat for another 20 minutes; reduce the liquid to 800ml, and divide into three doses to be taken in the morning, noon, and evening. Symptoms of dizziness, headache, and insomnia are significantly relieved, and appetite and bowel movements return to normal. Continue taking the above formula as a water-based pill for 3 months, until symptoms completely disappear.

[0076] Comparative Example 1

[0077] Ms. Wu, female, 65 years old, has suffered from recurrent dizziness for over 20 years, which has worsened in the past week. She reports that her dizziness, headache, and insomnia significantly worsened after two COVID-19 infections in December 2022 and May 2023. She had previously self-medicated with Gastrodia and Polygonum multiflorum tablets, which provided some relief. In 2020, she visited a hospital and underwent an intracranial CTA, which revealed a left internal carotid artery clinoid segment aneurysm, approximately 3mm in diameter. A follow-up examination in 2021 showed no significant increase in aneurysm size. In 2023, an intracranial CT scan and intracranial CTA at the same hospital showed an aneurysm approximately 4*3mm in size. One week ago, the dizziness recurred, and she came to our outpatient clinic today seeking further treatment with both traditional Chinese and Western medicine. Current symptoms include dizziness, headache, insomnia, occasional nausea and vomiting, dry and bitter mouth, slight sighing, poor appetite, difficulty falling asleep, frequent dreams and easy awakening, but able to fall back asleep after waking. Bowel movements are normal. Her tongue is red with little coating, and her pulse is wiry and thready. Prescription: Kudzu root 90g, Sichuan lovage rhizome 70g, *Hemiberlesia lingua* root 80g, hawthorn fruit 90g, white mustard seed 60g, turmeric 60g, astragalus root 30g, angelica root 60g, white peony root 140g, bupleurum root 90g, albizia bark 140g, cyperus rhizome 90g, gastrodia rhizome 90g, ground beetle 80g, rhodiola rosea root 70g, hematite 90g. 7 doses, one dose daily. Soak in 3 times the amount of water for 20 minutes, bring to a boil over high heat, then simmer over low heat for another 20 minutes; reduce the liquid to 800ml, and divide into three doses to be taken in the morning, noon, and evening. Symptoms of dizziness, headache, and insomnia were slightly relieved; appetite improved, and bowel movements returned to normal. One week later, the prescription was adjusted to: 90g of kudzu root, 70g of chuanxiong rhizome, 80g of *Hemiberlesia lingua* root, 90g of hawthorn fruit, 60g of white mustard seed, 60g of turmeric, 30g of astragalus root, 60g of angelica root, 140g of white peony root, 90g of bupleurum root, 140g of albizia bark, 90g of cyperus rhizome, 90g of gastrodia rhizome, 80g of ground beetle, 70g of rhodiola rosea root, 90g of hematite, 140g of agrimony, 140g of deer antler velvet, and 100g of *Lysimachia christinae*. The difference from the prescription a week prior was the addition of 140g each of agrimony, deer antler velvet, and *Lysimachia christinae*. One week later, the patient's dizziness, headache, and insomnia symptoms were significantly relieved. The prescription was continued according to the above proportions, modified to a water-based pill formula, and continued for one year until the symptoms completely disappeared.

[0078] Comparative Example 2

[0079] Ms. Xia, female, 45 years old, has experienced recurrent dizziness for over a year, which has worsened in the past week. She reports that her insomnia and dizziness have worsened since May 2023. Current symptoms: palpitations, chest tightness, dizziness, difficulty falling asleep at night, acid reflux and heartburn, good appetite, normal bowel movements, pale tongue with white coating, and a thready, rapid pulse. Prescription: Kudzu root 160g, Chuanxiong rhizome 90g, Hedyotis diffusa rhizome 90g, Crataegus pinnatifida fruit 210g, White mustard seed 70g, Turmeric rhizome 70g, Astragalus membranaceus root 80g, Angelica dahurica root 80g, White peony root 140g, Bupleurum chinense root 70g, Albizia julibrissin bark 90g, Cyperus rotundus rhizome 90g, Gastrodia elata rhizome 70g, Eupolyphaga sinensis root 70g, Rhodiola rosea root 80g, Hematite 90g. 7 doses, one dose daily. Soak in 3 times the amount of water for 20 minutes, bring to a boil over high heat, then simmer over low heat for another 20 minutes; reduce the liquid to 800ml, and divide into three doses to be taken in the morning, noon, and evening. The symptoms of dizziness, headache, and insomnia were slightly relieved. One week later, the prescription was adjusted to: 160g of kudzu root, 90g of chuanxiong rhizome, 90g of *Hemiptera japonica* root, 210g of hawthorn fruit, 70g of white mustard seed, 70g of turmeric, 80g of astragalus root, 80g of angelica root, 140g of white peony root, 70g of bupleurum root, 90g of albizia bark, 90g of cyperus rhizome, 70g of gastrodia rhizome, 70g of ground beetle, 80g of rhodiola rosea, 90g of hematite, 140g of agrimony, 140g of *Pyrola rotundifolia* herb, and 70g of *Lysimachia christinae* herb. The difference from the prescription a week prior was the addition of 140g of agrimony, 140g of *Pyrola rotundifolia* herb, and 70g of *Lysimachia christinae* herb. One week later, the patient's symptoms of dizziness, headache, and insomnia were significantly relieved. The prescription was then changed to a water-based pill formula, and continued for three months until the symptoms completely disappeared. This invention focuses on the complex pathogenesis of cerebral fog associated with COVID-19 syndrome, and proposes targeted treatment methods such as nourishing blood and regulating qi, resolving phlegm and dispersing blood stasis, soothing the liver and relieving depression, refreshing the mind and calming the brain, and dispelling wind and relieving pain. The formula of this invention was precisely screened, and clinical observation has found that the formula of this invention has definite curative effect and has strong clinical translational value.

[0080] The above embodiments describe preferred embodiments of the present invention, but the present invention is not limited thereto. Within the scope of the inventive concept, various simple modifications can be made to the technical solutions of the present invention, including combinations of various technical features in any other way. These simple modifications and combinations should also be considered as the content disclosed in the present invention and are all within the protection scope of the present invention. Therefore, the protection scope of this patent should be determined by the appended claims.

Claims

1. The application of a traditional Chinese medicine composition in the preparation of a drug for treating cerebral fog associated with chronic COVID-19 syndrome, characterized in that, The composition is made from the following raw materials in parts by weight: 15-30 parts of kudzu root, 15-20 parts of chuanxiong rhizome, 15-20 parts of rock hemp root, 10-20 parts of hawthorn fruit, 6-9 parts of white mustard seed, 6-9 parts of turmeric, 10-15 parts of astragalus root, 15-20 parts of deer antler grass, 10-12 parts of angelica root, 20-30 parts of white peony root, 6-9 parts of bupleurum root, 15-30 parts of albizia bark, 10-15 parts of cyperus rhizome, 15-20 parts of gastrodia rhizome, 15-30 parts of agrimony, 10-12 parts of ground beetle, 12-15 parts of rhodiola rosea, 15-20 parts of hematite, and 15-20 parts of indigo naturalis. In the specific preparation of this drug, each raw material component is weighed according to the formula, soaked in water, then heated and decocted, the decoction is filtered and collected, and finally the decoction is concentrated to obtain decoction, tablets, pills, powders, capsules or granules. The clinical manifestations of long-term COVID-19 syndrome-related brain fog are two or more of the following symptoms: dizziness, headache, and insomnia, which appear or worsen after COVID-19 infection.

2. The application according to claim 1, characterized in that: The composition is made from the following raw materials in parts by weight: 30 parts of kudzu root, 15 parts of chuanxiong rhizome, 15 parts of rockwort, 10 parts of hawthorn, 6 parts of white mustard seed, 6 parts of turmeric, 15 parts of astragalus root, 15 parts of deer antler grass, 10 parts of angelica root, 20 parts of white peony root, 6 parts of bupleurum root, 30 parts of albizia bark, 10 parts of cyperus rhizome, 15 parts of gastrodia rhizome, 20 parts of agrimony, 10 parts of ground beetle, 15 parts of rhodiola rosea, 15 parts of hematite, and 15 parts of indigo naturalis.

3. The application according to claim 1, characterized in that: Add water at a rate of 3 times the mass of the raw materials; decoct for 20-30 minutes to concentrate into a soup.

4. The application according to claim 1, characterized in that: The amount of water added is 5 to 6 times the mass of the raw material components; the decoction time is 30 to 40 minutes; after filtration, the residue is added to 2 to 3 times the amount of water and decocted for another 30 to 40 minutes; after filtration, the decoctions are combined and concentrated to prepare a pharmaceutically acceptable dosage form.

5. The application according to claim 4, characterized in that: The dosage form is tablet, pill, powder, capsule or granule.

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