An external use herbal essence with improved skin itching

Abstract

The application discloses a kind of external use herbal essence with improving skin itching, which is composed of Tripterygium wilfordii Hook.f., Selaginella tamariscina, Senecio scandens Buchen, Viburnum dilatatum, water wong root and chestnut shell.The present prescription combines wind-heat, damp-heat and blood-heat, and has the effects of clearing heat and cooling blood, dispelling wind and relieving itching.It has achieved good effects in treating patients with skin itching, especially in treating peeling, dandruff and epidermal crack caused by dry skin after skin itching.The present application not only solves the problem of skin itching, but also makes the skin smooth and moisturized after treatment, and solves the problem of dry skin.Compared with western medicine, the present application has no side effects, fast curative effect, low cost and convenient use.

Description

TECHNICAL FIELD

[0001] The present application relates to an external use essence, in particular to an external use herbal essence with the function of improving skin itching. BACKGROUND

[0002] Skin itching belongs to neurosis of skin disease, which is a skin neurosis disease. Clinically, only skin itching without primary skin damage is called pruritus. It belongs to the category of "itching wind" in traditional Chinese medicine. Skin itching is divided into common type and allergic type. It can occur all over the body, especially on the face, back and limbs. Common type of skin itching is usually caused by dry skin.

[0003] The common causes of skin itching in clinic are neurodermatitis, tinea corporis, eczema, mosquito bites or allergy, etc. Itching is a subjective feeling that triggers the desire to scratch, which originates from the skin and mucous membrane and has various forms. The skin lesions are papules, papulovesicles, blisters, etc. on the basis of erythema, and the itching is unbearable, or it is in patches, wheals, or accompanied by scratches, or only itching without any skin lesions. Skin itching disease is prone to recurrence, which seriously affects the normal work and life of patients. At present, the external use drugs for treating skin itching are mainly hormone drugs. Long-term use of such hormone drugs will cause skin dryness, peeling, fine cracks, or changes in body function. Therefore, it is necessary to study a traditional Chinese medicine external preparation which can not only improve skin itching, but also relieve skin dryness, prevent skin peeling and fine cracks.

[0004] Luo Shiteng is the leafy stem of the plant Vitex trifolia L. It is slightly cold in nature and bitter in taste. It has the functions of dredging collaterals to stop pain, cooling blood to clear heat, and detoxifying and detumescing. Huo Bai is a soil or stone resuscitation plant of the genus Selaginella in the family Selaginellaceae, which is in the form of a mat. It reproduces by spores. Huo Bai, also known as Jiushi Huanhuncao, is not only ornamental but also medicinal. The whole grass has the functions of stopping bleeding and astringing. Chongliuguang is a herbaceous plant of the family Asteraceae, which grows in mountain slopes, sparse forests, forest edges, roadsides and ditch edges. It is cold in nature and bitter in taste, and has the functions of clearing heat and resolving toxins, clearing eyesight and stopping itching. It is often used for treating wind-heat cold, red and swollen eyes, dysentery, and skin eczema. Yingbupo is the root of the plant Vitex trifolia L. It has the functions of dispelling wind, resolving dampness, detumescing and dredging collaterals. It is used to treat sore throat, jaundice, malaria, rheumatic pain and contusion. Shuiwenggen is the root of the plant Rhodomyrtus tomentosa, which is bitter in taste and cool in nature. It has the functions of clearing heat and resolving dampness, and relieving pain. Banliqie is a kind of nut plant of the genus Castanea in the family Fagaceae. Chestnut shell is the outer pericarp of Castanea mollissima Blume, which is sweet, astringent and flat in nature, and has the functions of descending adverse qi and stopping bleeding.

[0005] BACKGROUND

[0006] Patent document CN102579623A discloses a method for preparing a traditional Chinese medicine wash for treating traumatic leg ulcers. The wash is composed of 15 herbs: *Smilax china*, *Euphorbia humifusa*, *Corydalis yanhusuo*, *Tungus tectorius*, *Artemisia capillaris*, *Ladyfoetida*, *Rhododendron molle*, *Caesalpinia sappan*, *Gleditsia sinensis*, *Commiphora myrrha*, *Spatholobus suberectus*, *Boswellia carterii*, *Eupatorium fortunei*, and *Selaginella tamariscina*. It possesses the following effects: promoting blood circulation and removing blood stasis, moistening dryness and lubricating the intestines, promoting blood circulation and dispelling wind, dispersing blood stasis and breaking up masses, promoting diuresis and reducing swelling, eliminating stagnation and relieving pain, promoting blood circulation and stopping bleeding, clearing heat and detoxifying, promoting diuresis and relieving jaundice, promoting blood circulation and removing blood stasis, reducing swelling and draining pus, dispelling wind and removing toxins, and treating eye diseases and removing corneal opacity.

[0007] Patent document CN102824421A discloses a method for preparing a traditional Chinese medicine wash for treating closed fractures of the startle type. It is composed of 31 raw materials including Polygonum multiflorum, Poria cocos, Achyranthes bidentata, Acer pentaphyllum, Illicium verum root, Aristolochia debilis, Piper kadsura, Trachelospermum jasminoides, Aristolochia debilis, Carthamus tinctorius, Salvia miltiorrhiza, and Paeonia suffruticosa. It has the effects of dispelling wind and dampness, relaxing muscles and relieving pain, dispelling wind and dampness, clearing meridians, breaking up blood stasis and promoting blood circulation, and removing blood stasis and relieving pain.

[0008] Patent document CN1814055A discloses a herbal remedy for relieving pain and promoting blood circulation, composed of *Dendrobium nobile* root, *Euphorbia pekinensis*, *Cynanchum paniculatum*, *Acanthopanax papyriferus*, *Justicia procumbens*, *Sedum aizoon*, *Trachelospermum jasminoides*, *Sedum sarmentosum* root, *Sedum aizoon*, *Chuifengsan*, and ethanol. It has the effects of dispelling wind and promoting qi circulation, activating blood circulation and relieving pain.

[0009] Patent document CN108653504A discloses a drug for treating ankylosing spondylitis and its preparation method. It is composed of Cibotium barometz, Aristolochia debilis, Tripterygium wilfordii, Scutellaria baicalensis, Spatholobus suberectus, Spatholobus suberectus, Aristolochia debilis, Aristolochia debilis, Angelica pubescens, Ligusticum chuanxiong, Gentiana macrophylla, Ligusticum striatum, Ligusticum striatum, Trachelospermum jasminoides, Homalomena occulta, Dipsacus asper, and Eucommia ulmoides. It has the effects of dispelling wind and strengthening the spine, removing blood stasis and relieving numbness, regulating the liver and kidneys, replenishing qi and blood, and relaxing muscles and bones.

[0010] Patent document CN112791010A discloses a chestnut shell aerogel sunscreen, which is a composite aerogel containing zinc oxide loaded with cellulose extracted from chestnut shells and composed of wolfberry polysaccharides and almond polypeptides, achieving multiple effects such as moisturizing, anti-oxidation, and anti-skin photoaging.

[0011] Patent document CN105663326A discloses a traditional Chinese medicine for treating jaundice, composed of chestnut shell, isatis root, turpentine oil, eleutherococcus senticosus, apricot kernel, and monk fruit. It is remarkably effective in treating jaundice symptoms where the sclera, mucous membranes, skin, and other tissues are stained yellow.

[0012] Patent document CN105770573A discloses a traditional Chinese medicine for treating chronic urticaria of the blood-dryness and wind type, which is composed of Akebia quinata, bamboo bee, golden thread, water amaranth, cattail root, eagle stalk, pitcher plant, crown fruit grass, stone nut, red horse hoof grass, hairy gourd tea hair, green sky sunflower hair, pepper vine, sweet potato vine, Su Xing flower, salty sour scallion, water lily root, clam powder and sorghum seven, which is highly targeted to chronic urticaria of the blood-dryness and wind type.

[0013] Patent document CN114146145A discloses a herbal essence liquid for dispelling cold and dampness, relaxing muscles and tendons, and promoting blood circulation. It is composed of peach leaves, mugwort leaves, lemongrass, gardenia, tangerine peel, chicken manure vine, pine vine, fragrant leaves, honeysuckle, salt-frost cypress, snake peony root, snake tongue grass, sugarcane frost vine, mulberry mistletoe, chicken blood vine, and water lily root, and has the effects of dispelling cold and dampness, relaxing muscles and tendons, and promoting blood circulation.

[0014] Patent document CN105012740A discloses a spray for treating itchy skin, which is composed of mulberry leaves, Senecio scandens, magnolia flowers, musk, lemongrass, artemisia annua, cloves and peppermint, and has the effects of detoxifying and relieving itching, sterilizing, dispelling wind and dispersing nodules, and accelerating skin healing.

[0015] Patent document CN104644764A discloses a medicine for treating acne, which is composed of *Smilax china*, *Elsholtzia ciliata*, *Gynostemma pentaphyllum*, *Eclipta prostrata*, *Gynostemma pentaphyllum*, *Selaginella tamariscina*, *Sarcandra glabra*, and *Panax notoginseng*. It has the effects of clearing heat and relieving exterior syndrome, promoting blood circulation and detoxifying, reducing swelling and relieving pain, and tonifying deficiency and relieving exterior syndrome.

[0016] Therefore, there is currently no literature reporting existing techniques for treating pruritus using a combination of Trachelospermum jasminoides, Selaginella tamariscina, Senecio scandens, chestnut shell, Sedum morganianum root, and Erythrina variegata. Summary of the Invention

[0017] The purpose of this invention is to provide a topical herbal essence that can improve skin itching. This essence can not only improve skin itching, but also solve problems such as peeling, flaking, and epidermal cracking caused by dry skin after treatment of skin itching.

[0018] The herbal essence of this invention is achieved through the following technical solution:

[0019] The raw materials for the herbal essence of this invention are composed of Trachelospermum jasminoides, Selaginella tamariscina, Senecio scandens, Eupatorium fortunei, Sedum morganianum root, and chestnut shell.

[0020] Preferably, the raw materials of the herbal essence of the present invention are composed of 20-60 parts by weight of Trachelospermum jasminoides, 22-68 parts by weight of Selaginella tamariscina, 15-45 parts by weight of Senecio scandens, 10-30 parts by weight of Aristolochia debilis, 7-23 parts by weight of Aristolochia debilis root, and 5-15 parts by weight of chestnut shell.

[0021] Preferably, the raw materials of the herbal essence of the present application are composed of 30-50 parts by weight of Tripterygium hypoglaucum, 35-55 parts by weight of Selaginella tamariscina, 20-40 parts by weight of Senecio scandens, 15-25 parts by weight of Berberis poiretii, 10-20 parts by weight of Sanguisorba officinalis and 7-13 parts by weight of Castanea mollissima.

[0022] Preferably, the raw materials of the herbal essence of the present application are composed of 40 parts by weight of Tripterygium hypoglaucum, 45 parts by weight of Selaginella tamariscina, 30 parts by weight of Senecio scandens, 20 parts by weight of Berberis poiretii, 15 parts by weight of Sanguisorba officinalis and 10 parts by weight of Castanea mollissima.

[0023] Preferably, the raw materials of the herbal essence of the present application are composed of 25 parts by weight of Tripterygium hypoglaucum, 60 parts by weight of Selaginella tamariscina, 20 parts by weight of Senecio scandens, 25 parts by weight of Berberis poiretii, 10 parts by weight of Sanguisorba officinalis and 12 parts by weight of Castanea mollissima.

[0024] Preferably, the raw materials of the herbal essence of the present application are composed of 55 parts by weight of Tripterygium hypoglaucum, 30 parts by weight of Selaginella tamariscina, 40 parts by weight of Senecio scandens, 15 parts by weight of Berberis poiretii, 20 parts by weight of Sanguisorba officinalis and 8 parts by weight of Castanea mollissima.

[0025] The present application also provides a preparation method of the external use herbal essence for improving skin itching, which comprises the following steps:

[0026] (1) The Tripterygium hypoglaucum, Selaginella tamariscina and Sanguisorba officinalis are washed with clean water, and then soaked in 2-6 times of water for 10-30 minutes, and then decocted, and the first decoction is performed for 1-3 hours, and the filtrate is obtained by filtration; the residue is decocted with 1-3 times of water for 0.5-1.5 hours, and the filtrate is obtained by filtration, and the two filtrates are combined, filtered, and centrifuged, and the supernatant A is obtained by centrifugation at 3000 rpm;

[0027] (2) The remaining Senecio scandens, Berberis poiretii and Castanea mollissima are washed, soaked in 3-9 times of water for 15-45 minutes, and then decocted, and the first decoction is performed for 1-3 hours, and the filtrate is obtained by filtration; the residue is decocted with 1-3 times of water for 0.5-1.5 hours, and the filtrate is obtained by filtration, and the two filtrates are combined, filtered, and concentrated to 60-100℃, and the relative density is 1.15-1.18, and then ethanol is added to make the alcohol content reach 65%, and then the supernatant is recovered for use after standing, and the extract B is obtained by concentrating to 80-90℃, and the relative density is 1.25-1.30;

[0028] (3) The supernatant A and the extract B are mixed uniformly, and then extracted with 0.5-1.5 times of water at 80-100℃ for 0.5-1.5 hours, and then the supernatant is obtained by standing, and the essence is obtained by taking the upper clear liquid.

[0029] (1) Weigh out the parts by weight of Trachelospermum jasminoides, Selaginella tamariscina and Sedum sarmentosum root, wash them with clean water, soak them in 4 times the amount of water for 20 minutes, and then decoct them. The first decoction is 2 hours, and the filtrate is filtered. The dregs are then decocted in 2 times the amount of water for 1 hour, filtered, and the filtrate is obtained. The two filtrates are combined, filtered, and the filtrate is centrifuged at 3000 rpm to separate the supernatant A.

[0030] (2) Wash the remaining Senecio scandens, eagle buds and chestnut shells, soak them in 6 times the amount of water for 30 minutes, then decoct them. The first decoction is 2 hours, filtered, and the filtrate is obtained. The dregs are then decocted in 2 times the amount of water for 1 hour, filtered, and the two filtrates are combined and filtered. The filtrate is concentrated to 80℃ and the relative density is measured to be 1.15-1.18. Ethanol is added to make the alcohol content reach 65%. The mixture is allowed to stand, and the supernatant is taken to recover the ethanol for later use, resulting in supernatant B.

[0031] (3) Mix supernatant A and supernatant B evenly, extract with 1 times the amount of water at 90°C for 1 hour, let the liquid stand, and take the clear liquid from the top to obtain the essence.

[0032] The present invention also provides the use of the essence in the preparation of a medicine for treating skin itching.

[0033] The present invention also provides the application of the essence in the preparation of a medicine for treating peeling, flaking, and epidermal cracking caused by dry skin after pruritus.

[0034] In this invention's essence formula, the principal herbs, *Trachelospermum jasminoides*, *Selaginella tamariscina*, and *Senecio scandens*, possess the effects of clearing the channels and relieving pain, cooling the blood and clearing heat, detoxifying and reducing swelling, stopping bleeding, astringing, clearing heat and detoxifying, improving eyesight, and relieving itching. The assistant herbs, *Euphorbia hirta* and *Smilax china* root, possess the effects of dispelling wind, resolving dampness, reducing swelling, clearing the channels, clearing heat and promoting diuresis, and regulating qi and relieving pain. The adjuvant herb, *Cephalotaxus fortunei* shell, possesses the effects of lowering adverse qi and stopping bleeding. The combination of these herbs allows them to directly reach the affected area. This formula addresses wind-heat, damp-heat, and blood-heat, possessing the effects of clearing heat and cooling the blood, dispelling wind and relieving itching. It has achieved excellent results in treating patients with pruritus, especially in treating peeling, flaking, and epidermal cracking caused by dry skin after pruritus. It not only solves the problem of pruritus but also leaves the skin smooth and moisturized after treatment, resolving dryness. Compared to Western medicine, it has no side effects, and is fast-acting, low-cost, and easy to use. It can be used for foot baths or medicated baths, the essence can also be used for fumigation, or it can be sprayed directly on the affected area.

[0035] The traditional Chinese medicine composition provided by this invention is suitable for itching symptoms caused by various skin diseases, such as acute eczema, chronic eczema, psoriasis, neurodermatitis, tinea corporis, mosquito bites or allergies, etc. Compared with common ointments on the market, it has fewer side effects. The skin treated by this invention is smooth and moisturized, not only is it well tolerated, but it also solves the problem of dry skin.

[0036] The following experimental examples are used to further illustrate the present application, but are not limited to the present application.

[0037] Experimental Example 1, Prescription Screening Test

[0038] 1. Experimental animals

[0039] 60 SPF level ICR male mice, weighing (23.4±0.22) g, were randomly divided into 6 groups, 10 mice in each group.

[0040] 2. Test drugs and administration regimen

[0041] Group 1 of Experiment: Luoshiteng 40 g, Juancheng 45 g, Qianliugong 30 g, Yingbupo 20 g, Shu'eng'eng 15 g and Banliqie 10 g. Preparation method: The above raw medicinal materials were washed with clean water, soaked in 4 times the amount of water for 20 minutes, then decocted, the first decoction was 2 hours, filtered to obtain the filtrate; the residue was decocted with 2 times the amount of water for 1 hour, filtered to obtain the filtrate, the two filtrates were combined, filtered, the filtrate was centrifuged at 3000 rpm, the supernatant was separated; the supernatant was left to stand, the upper clear liquid was taken to obtain the essence liquid.

[0042] Group 2 of Experiment: Luoshiteng 40 g, Juancheng 45 g, Qianliugong 30 g, Yingbupo 20 g and Shu'eng'eng 15 g. The preparation method was the same as that of Group 1 of Experiment.

[0043] Group 3 of Experiment: Luoshiteng 40 g, Juancheng 45 g, Qianliugong 30 g and Banliqie 10 g. The preparation method was the same as that of Group 1 of Experiment.

[0044] Group 4 of Experiment: Luoshiteng 40 g, Juancheng 45 g and Qianliugong 30 g. The preparation method was the same as that of Group 1 of Experiment.

[0045] Group 5 of Experiment: Yingbupo 20 g, Shu'eng'eng 15 g and Banliqie 10 g. The preparation method was the same as that of Group 1 of Experiment.

[0046] The essence liquid of the above-mentioned Groups 1-5 of Experiment was respectively sprayed on the neck and back of the mice in Groups 1-5 of Experiment. Twice a day, once at 9 o'clock in the morning and once at 5 o'clock in the afternoon, for 14 consecutive days.

[0047] Another group of mice was taken as the model control group, and the mice in this group were not given any drug treatment.

[0048] 3. Preparation of mouse model

[0049] The hair on the back of the neck of the mice was shaved (from the line connecting the two ears to the second thoracic vertebra segment, an area of about 2 cm x 2 cm) until the skin was completely exposed. The dry skin itching model of the mice was prepared by AEW sequential coating method, equal volumes of acetone and ether were mixed, cotton was soaked, and at 9 o'clock in the morning and 5 o'clock in the afternoon, the back of the neck of the mice was coated for 15 s, and then cotton soaked in distilled water was coated on the same site for 30 s, for 7 consecutive days. When recording the number of scratches of the mice, a transparent cage of 12 cm x 12 cm x 12 cm was selected, which not only avoided the small container causing the mice to be nervous and anxious to scratch and affecting the results, but also avoided the large container being inconvenient to count due to the recording error. The mice were photographed before coating every day, and the last coating was more than 15 h apart, which avoided the itching caused by the stimulation of the reagent itself to the experimental animals, and objectively reflected the number of scratches of the mice.

[0050] 4. Scratch behavior determination

[0051] The severity of itching was evaluated by counting the number of scratches of the mice for 1 h. On the 1st, 3rd, 5th, and 7th days of modeling, the mice were placed in a transparent observation cage of 12 cm x 12 cm x 12 cm, and after adapting for 10 min, they were continuously photographed for 1 h in a quiet environment, and the number of scratches of the mice was counted. The mouse hind paw left the ground, and the skin of the back of the neck coated site was scratched once or more times, the hind paw fell to the ground, or the mouse licked, ate, and bit the hind paw, which was counted as one scratch. The front paw scratch or the hind paw scratch of the skin other than the coated site was not counted.

[0052] 5. Test results

[0053] The results of the anti-itching effect of the mouse model are shown in Table 1.

[0054] Table 1 Comparison of anti-itching effects of mice in each group after drug administration

[0055] Group Example Pruritus frequency (times) before treatment Pruritus frequency (times) after treatment Model control group 10 24.43±2.78** 21.64±2.32** Example 1 group 10 25.75±2.56** 2.08±0.32 Example 2 group 10 26.08±3.02** 3.04±0.38 Example 3 group 10 27.01±3.43** 3.26±0.41 Example 4 group 10 25.47±2.65** 3.58±0.48 Example 5 group 10 24.98±2.57** 13.48±0.63**

[0056] Note: Compared with the model control group and experimental groups 1-5, *P<0.05, **P<0.01.

[0057] The anti-itching effect can be evaluated by the number of times of itching. As shown in Table 1 above, the number of times of itching in experimental groups 1-5 was significantly lower than that in the model control group, and the difference was statistically significant (P<0.01).

[0058] The number of times of itching in the experimental groups 1-4 was lower than that in the experimental group 5, and the difference was statistically significant. The number of times of itching in the experimental group 1 was lower than that in the experimental groups 2, 3 and 4. The experimental results show that the experimental group 1 has a better anti-itching effect on the mouse model, can significantly reduce the number of times of itching in mice, and significantly reduce the duration of itching. It shows that only the combination of monarch, minister and assistant drugs can make the drugs in the prescription directly reach the disease. The prescription in the experimental group 1 combines wind-heat, damp-heat and blood-heat, and has the effects of clearing heat and blood, dispelling wind and relieving itching. Through the mutual compatibility of different traditional Chinese medicines, the prescription in the experimental group 1 conforms to the theory of traditional Chinese medicine, plays a synergistic effect, and achieves a more ideal itching-relieving effect.

[0059] Experimental Example Two, Clinical Experiment

[0060] 1. Clinical Effect Test of Eczema

[0061] 1.1 Case Data

[0062] Select 90 cases of eczema patients from January 2020 to January 2021, including 45 cases of acute eczema and 45 cases of chronic eczema. Randomly divided into three groups: treatment group, control group 1 and control group 2, three groups respectively 30 cases (acute eczema and chronic eczema each 15 cases). Among them, 21 cases of male and 29 cases of female in the treatment group, aged 21-65 years old, with an average age of 43 years old, the average course of disease was 4-28 months, 15 cases of acute eczema, 18 cases of subacute eczema and 17 cases of chronic eczema; 23 cases of male and 27 cases of female in the control group, aged 20-64 years old, with an average age of 42 years old, the average course of disease was 6-26 months, 16 cases of acute eczema, 14 cases of subacute eczema and 20 cases of chronic eczema. There was no significant difference in gender, age and disease severity between the two groups (P>0.05).

[0063] 1.2 Diagnosis Standard

[0064] Refer to "Diagnosis and Efficacy Standard of TCM Dermatology".

[0065] 1.2.1 Acute Eczema

[0066] (1) The skin lesions are polymorphic, such as erythema, papules, blisters, erosion, exudation, scab, desquamation, and often several forms exist at the same time.

[0067] (2) The onset is acute, with a burning sensation and severe itching.

[0068] (3) The skin lesions are often symmetrically distributed, and are often seen on the head, face, distal extremities, scrotum and other parts. It can be generalized.

[0069] (4) It can develop into subacute or chronic eczema, with mild and severe symptoms, and repeated non-healing.

[0070] 1.2.2 Chronic eczema

[0071] Multiple localized in a certain part, clear boundary, with obvious hypertrophic infiltration, rough surface, or lichenoid change, brown or brown color, often accompanied by papulovesicles, scab, scratch marks. Tendency to wet change, often recurrent, sometimes heavy, with paroxysmal itching.

[0072] 1.3 Inclusion criteria

[0073] (1) 18 years of age ≤ age ≤ 65 years, regardless of gender; (2) No history of allergic reaction to Chinese medicine; (3) No serious primary diseases of heart, brain, blood vessels, liver, kidney and hematopoietic system, non-psychiatric patients; (4) No use of steroid hormones in the past two weeks, no use of antihistamines or no use of external corticosteroid preparations in the past week; (5) No signs of infection in the skin lesions; (6) Sign the informed consent form.

[0074] 1.4, Exclusion criteria

[0075] (1) Age below 18 years old or above 65 years old, pregnant or lactating women; (2) Have a history of allergic reaction to Chinese medicine; (3) Combined with serious primary diseases of heart, brain, blood vessels, liver, kidney and hematopoietic system and psychiatric patients; (4) Use of steroid hormones in the past two weeks, use of antihistamines or use of external corticosteroid preparations in the past week. (5) Unable to determine the efficacy of the drug as prescribed; (6) There are signs of infection in the skin lesions.

[0076] 1.5 Test drug

[0077] Treatment group 1: prepared according to the method of Example 1. Method of use: The essence is directly sprayed on the affected area, twice a day, for 2 weeks of continuous use.

[0078] Treatment group 2: Lu Shiteng 40g, Ju Bai 45g and Qianli Guang 30g. The above raw materials are washed with clean water, soaked with 4 times the amount of water for 20 minutes, then decocted, the first decoction for 2 hours, filtered to obtain the filtrate; The dregs are decocted with 2 times the amount of water for 1 hour, filtered to obtain the filtrate, and the two filtrates are combined, filtered, and the filtrate is centrifuged at 3000 rpm to separate the supernatant. The supernatant is allowed to stand, and the upper clear liquid is taken to obtain the essence. Method of use: The essence is directly sprayed on the affected area, twice a day, for 2 weeks of continuous use.

[0079] Control group 1 uses compound dexamethasone acetate cream, produced by Henan Daxin Pharmaceutical Co., Ltd. Method of use: The cream is directly applied to the affected area, twice a day, for 2 weeks of continuous use.

[0080] 1.6 Efficacy evaluation criteria

[0081] 1.6.1 Observation index and recording method of clinical efficacy

[0082] 1.6.1.1 Itching Symptom Scoring Table

[0083] An intuitive scoring method was used to record the improvement of patients' itching symptoms before and after treatment, as shown in Table 1.

[0084] Table 1. Itching Symptom Scoring Table

[0085] Score Symptom 0 points No any discomfort 1 point Mild pruritus, whether taking medicine or not has little effect on pruritus symptoms 2 points Moderate pruritus, affecting work and life, but controllable scratching, requiring medication to relieve 3 points Severe pruritus, scratching is severe, cannot carry out normal work and study, and it is difficult to relieve with medicine.

[0086] 1.6.2 Evaluation of therapeutic effect

[0087] Treatment efficacy assessment based on lesion area and severity score (EASI):

[0088] Referring to the EASI score established in the "Guiding Principles for Clinical Research of New Traditional Chinese Medicine for the Treatment of Eczema," the efficacy index was used as the indicator for judging efficacy. The efficacy index (EASI score reduction rate) = (pre-treatment score - post-treatment score) / pre-treatment score × 100%, specifically: Cured ≥ 95%; Significantly effective ≥ 70% and < 95%; Effective ≥ 30% and < 70%; Ineffective < 30%. The total effective rate = (number of cured cases + number of significantly effective cases + number of effective cases) / total number of cases in this group × 100%).

[0089] 1.7 Treatment Results for Pruritus

[0090] 1.7.1 Comparison of EASI scores before and after treatment, as shown in Table 2.

[0091] Table 2 Comparison of EASI scores before and after treatment in the two groups

[0092] Grouping Before treatment After treatment Treatment group 1 22.32±5.362 3.65±0.318 Treatment group 2 22.16±4.768 4.58±0.414 Control group 1 22.27±4.865 7.86±0.665

[0093] As shown in Table 2, there were significant differences in EASI scores between the control group and treatment groups 1 and 2 after treatment (P<0.05), indicating that treatment groups 1-2 were superior to control group 1.

[0094] 1.7.2 Comparison of itching symptom scores after treatment

[0095] Table 3 Comparison of itching symptom scores after treatment.

[0096] Grouping Before treatment After treatment Treatment group 1 2.32±0.662 0.28±0.025 Treatment group 2 2.28±0.532 0.32±0.026 Control group 1 2.21±0.582 0.68±0.026

[0097] As shown in Table 3, after the treatment, the pruritus symptom scores of the three groups were compared, and the differences between the three groups before and after treatment were compared (P<0.05), which showed significant statistical significance. This indicates that the treatment group 1-2 was better than the control group 1 in improving pruritus symptoms.

[0098] 1.7.3 Comparison of treatment efficacy for post-treatment itching symptoms

[0099] Table 4 Comparison of treatment efficacy for eczema and itching symptoms after treatment

[0100] Grouping Cured (cases) Effective (cases) Effective (cases) Ineffective (cases) Effective rate % Treatment group 1 16 8 5 1 96.7 Treatment group 2 15 8 4 3 90 Control group 1 8 7 10 5 83.3

[0101] From Table 4, the efficacy of the three groups of patients with pruritus symptoms of eczema after treatment was compared between groups, and there was a significant difference (P<0.05) among the three groups, and the total effective rate of treatment group 1 was 96.7%, and the total effective rate of treatment group 2 was 90%, which was significantly better than that of control group 1.

[0102] Table 5 Comparison of the efficacy of acute eczema pruritus symptoms after treatment

[0103] Grouping Cured (cases) Effective (cases) Effective (cases) Ineffective (cases) Effective rate % Treatment group 1 10 3 2 0 100 Treatment group 2 8 5 2 1 96.7 Control group 1 5 4 4 2 86.7

[0104] From Table 5, the efficacy of the three groups of patients with pruritus symptoms of acute eczema after treatment was compared between groups, and there was a significant difference (P<0.05) between treatment group 1 and treatment group 2 and control group 1, and the total effective rate of treatment group 1 was 100%, and the total effective rate of treatment group 2 was 96.7%, which was significantly better than that of control group 1.

[0105] Table 6 Comparison of the efficacy of chronic eczema pruritus symptoms after treatment

[0106] Grouping Cured (cases) Effective (cases) Effective (cases) Ineffective (cases) Effective rate % Treatment group 1 6 5 3 1 93.3 Treatment group 2 7 3 3 2 86.7 Control group 1 3 3 6 3 80

[0107] From Table 6, the efficacy of the three groups of patients with pruritus symptoms of chronic eczema after treatment was compared between groups, and there was a significant difference (P<0.05) among the three groups, and the total effective rate of treatment group 1 was 93.3%, which was significantly better than that of treatment group 2 and control group 1.

[0108] 1.8 Results of skin dryness after treatment

[0109] Table 7 Comparison of the results of skin dryness after treatment

[0110]

[0111] From Table 7, the results of skin dryness of the three groups of patients with chronic eczema pruritus after treatment were compared, and treatment group 1 was significantly better than treatment group 2 and control group 1, and there was a significant difference (P<0.05) among the three groups. And the skin of treatment group 1 was light and moisturizing after treatment, and the anti-dryness rate was 96.7%. The skin of treatment group 2 was severely dry after treatment, and there were phenomena such as dandruff, peeling, and epidermal cracks, and the anti-dryness rate was 16.7%. The skin of control group 1 also had dryness problems after treatment, and there were phenomena such as dandruff, peeling, and epidermal cracks, which was significantly different from treatment group 2 (P<0.05), and the anti-dryness rate was 56.7%.

[0112] 1.9 Discussion

[0113] In summary, the treatment group 1 is slightly better than the treatment group 2 in treating the skin itching caused by acute eczema, and the comparison result has no significant difference; the treatment group 1 is obviously better than the treatment group 2 in treating the skin itching caused by chronic eczema, and the comparison result has significant difference. However, after the treatment of the skin itching, the skin dryness of the treatment group 2 is serious, and a large number of chipping, peeling, epidermal crack and other phenomena occur. After the hawk not to the root of water and chestnut shell are added to the raw material medicine of the treatment group 2, the treatment group 1 can overcome the defects of the treatment group 2, effectively solve the problems of chipping, peeling and epidermal crack caused by the skin dryness, and also make the skin smooth and moisturizing, and the anti-dry effect is obvious.

[0114] The herbal essence liquid of the treatment group 1 has obvious antipruritic effect and skin lesion regression effect as a non-hormone external preparation, and the effect occurs quickly without adverse reactions. The itching symptoms of most subjects are obviously improved 1-3 days after the use of the medicine, the local scratching and other adverse stimulation are reduced, the lesions such as erythema and papules are gradually regressed, the skin is smooth and moisturizing after the use, and the anti-dry effect is obvious. Especially for the parts not suitable for long-term use of hormone preparations such as the face, the herbal essence liquid is more suitable, and is a new external preparation worthy of promotion in the clinical dermatology.

[0115] Experimental example three, pharmacodynamics test

[0116] 1. Experimental animals

[0117] 60 SPF level ICR male mice with a body weight of (22.8±0.21) g were randomly divided into 6 groups, 10 mice in each group.

[0118] 2. Test drugs and administration scheme

[0119] Three groups of experimental mice were taken as example 1 group, example 2 group and example 3 group of the application, and the mice in the three groups were respectively sprayed with the essence liquid prepared according to the method of example 1, example 2 and example 3 of the application on the neck and back of the mice. The mice were sprayed twice a day, once at 9 o'clock in the morning and once at 5 o'clock in the afternoon, and the spraying was continuously used for 10 days.

[0120] Two groups of experimental mice were taken as positive control group 1 and positive control group 2. The positive control group 1 used compound dexamethasone acetate cream produced by Henan Daxin Pharmaceutical Co., Ltd., and the drug was applied on the neck and back of the mice twice a day, once at 9 o'clock in the morning and once at 5 o'clock in the afternoon, and the application was continuously used for 7 days. The positive control group 2 used calamine lotion produced by Shanghai Xiaofang Pharmaceutical Co., Ltd., and the lotion was applied on the neck and back of the mice twice a day, once at 9 o'clock in the morning and once at 5 o'clock in the afternoon, and the application was continuously used for 7 days.

[0121] In addition, one group of mice was taken as a model control group, and the mice in the group were not given any drug treatment.

[0122] 3. Preparation of mouse model

[0123] The dorsal skin of the mouse was shaved (from the line connecting the two ears to the second thoracic vertebra segment, with an area of about 2 cm x 2 cm) until the skin was completely exposed. The mouse model of dry skin pruritus was prepared by AEW sequential application method. Equal volumes of acetone and ether were mixed, cotton was soaked, and the dorsal skin of the mouse was applied for 15 s at 9 am and 5 pm, then the same site was applied with distilled water-soaked cotton for 30 s, for 7 consecutive days. A 12 cm x 12 cm x 12 cm transparent cage was used to record the number of scratches when the mouse was photographed, which not only avoided the small container causing the mouse to be nervous and anxious to scratch and affect the results, but also avoided the large container being inconvenient to count and making mistakes. The mouse was photographed before applying the medicine every day, and the last application was more than 15 h apart, which avoided the itching caused by the stimulation of the reagent itself to the experimental animal, and objectively reflected the number of scratches of the mouse.

[0124] 4. Scratch behavior determination

[0125] The severity of pruritus was evaluated by counting the number of scratches of the mouse in 1 h. On the 1st, 3rd, 5th, and 7th days after modeling, the mouse was placed in a 12 cm x 12 cm x 12 cm transparent observation cage, and after 10 min of adaptation, the mouse was continuously photographed for 1 h in a quiet environment, and the number of scratches was counted. The mouse's hind paw left the ground, and the skin of the dorsal part of the neck was scratched once or more times, the hind paw fell to the ground, or the mouse licked, ate, and bit the hind paw, which was counted as one scratch. The front paw scratch or the hind paw scratch of the skin other than the applied part was not counted.

[0126] 5. Test results

[0127] The results of the anti-pruritic effect of the mouse model are shown in Table 1.

[0128] Table 1 Comparison of anti-pruritic effects of mice in each group after administration

[0129]

[0130] Note: Compared with Example 1-3 group, *P<0.05, **P<0.01.

[0131] The anti-pruritic effect can be evaluated by the number of pruritus. As shown in Table 1 above, the number of pruritus in Example 1-3 group, positive control group 1-2 group was significantly lower than that in the model control group, and the difference was statistically significant (P<0.01).

[0132] The number of times of itching of the example 1-3 group is lower than that of the positive control group 1 and the positive control group 2, and the difference is statistically significant. The experimental results show that the example 1-3 group has a good anti-itching effect on the mouse model, can obviously reduce the number of times of itching of the mouse, and significantly reduce the duration of itching; in particular, the example 1 group has a particularly prominent effect. It is shown that the composition of the example 1-3 group, by the mutual compatibility of different traditional Chinese medicines, conforms to the theory of traditional Chinese medicine, and has a synergistic effect, and a more ideal antipruritic effect is obtained.

[0133] The following examples can achieve the effect of the above experimental example. DETAILED DESCRIPTION

[0134] The application will be further described by the following examples. It should be understood that the examples of the application are used to illustrate the application rather than limit the application. Simple improvements made to the application according to the essence of the application all belong to the scope of the application claimed.

[0135] Example 1

[0136] The herbal essence of the application is composed of 40 g of Tripterygium hypoglaucum, 45 g of Selaginella sinensis, 30 g of Senecio scandens, 20 g of Aconitum pendulum, 15 g of Saururus chinensis and 10 g of Castanea mollissima.

[0137] The preparation method is as follows: Tripterygium hypoglaucum, Selaginella sinensis and Saururus chinensis are weighed according to the above weight, washed with clean water, soaked in 4 times the amount of water for 20 minutes, then decocted, the first decoction is 2 hours, filtered to obtain the filtrate; the residue is decocted with 2 times the amount of water for 1 hour, filtered to obtain the filtrate, and the two filtrates are combined, filtered, and the filtrate is centrifuged at 3000 rpm to obtain the supernatant A; the remaining Senecio scandens, Aconitum pendulum and Castanea mollissima are washed, soaked in 6 times the amount of water for 30 minutes, then decocted, the first decoction is 2 hours, filtered to obtain the filtrate, the residue is decocted with 2 times the amount of water for 1 hour, filtered to obtain the filtrate, and the two filtrates are combined, filtered, and the filtrate is concentrated to 80 DEG C to measure the relative density of 1.15-1.18, ethanol is added to make the alcohol content reach 65%, and then the supernatant is recovered for use; and the filtrate is concentrated to 85 DEG C to measure the relative density of 1.25-1.30 to obtain the extract B. The supernatant A and the extract B are uniformly mixed, 1 times the amount of water is added at 90 DEG C for 1 hour, the liquid medicine is placed, the upper clear liquid is taken after standing, and the herbal essence is obtained.

[0138] Example 2

[0139] The herbal essence of the application is composed of 40 g of Tripterygium hypoglaucum, 45 g of Selaginella sinensis, 30 g of Senecio scandens, 20 g of Aconitum pendulum, 15 g of Saururus chinensis and 10 g of Castanea mollissima.

[0140] The preparation method is as follows: the Tripterygium wilfordii Hook. f., Wolfsbane and water-willow roots are washed with clean water, 4 times of water is added to soak for 20 minutes, then decocting, the first decocting is 2 hours, filtering to obtain filtrate; the residue is decocted with 2 times of water for 1 hour, filtering to obtain filtrate, the two filtrates are combined, filtering, the filtrate is centrifuged, centrifuging at 3000 rpm, the supernatant A is obtained; the rest of the Serratula wolongensis, Wolfsbane and chestnut shell is washed, 6 times of water is added to soak for 30 minutes, then decocting, the first decocting is 2 hours, filtering to obtain filtrate, the residue is decocted with 2 times of water for 1 hour, filtering to obtain filtrate, the two filtrates are combined, filtering, the filtrate is concentrated to 80 DEG C, the relative density is 1.15-1.18, ethanol is added to reach 65% of alcohol content, standing, the supernatant is recovered for use; and the extract B is concentrated to 85 DEG C, the relative density is 1.25-1.30. The supernatant A and the extract B are mixed uniformly, 1 times of water is added to extract for 1 hour at 90 DEG C, standing, the supernatant is obtained, the herbal essence is obtained.

[0141] Example 3

[0142] The herbal essence is composed of Tripterygium wilfordii Hook. f. 55g, Wolfsbane 30g, Serratula wolongensis 40g, Wolfsbane 15g, water-willow root 20g and chestnut shell 8g.

[0143] The preparation method is as follows: the Tripterygium wilfordii Hook. f., Wolfsbane and water-willow roots are washed with clean water, 4 times of water is added to soak for 20 minutes, then decocting, the first decocting is 2 hours, filtering to obtain filtrate; the residue is decocted with 2 times of water for 1 hour, filtering to obtain filtrate, the two filtrates are combined, filtering, the filtrate is centrifuged, centrifuging at 3000 rpm, the supernatant A is obtained; the rest of the Serratula wolongensis, Wolfsbane and chestnut shell is washed, 6 times of water is added to soak for 30 minutes, then decocting, the first decocting is 2 hours, filtering to obtain filtrate, the residue is decocted with 2 times of water for 1 hour, filtering to obtain filtrate, the two filtrates are combined, filtering, the filtrate is concentrated to 80 DEG C, the relative density is 1.15-1.18, ethanol is added to reach 65% of alcohol content, standing, the supernatant is recovered for use; and the extract B is concentrated to 85 DEG C, the relative density is 1.25-1.30. The supernatant A and the extract B are mixed uniformly, 1 times of water is added to extract for 1 hour at 90 DEG C, standing, the supernatant is obtained, the herbal essence is obtained.

[0144] Example 4

[0145] The herbal essence is composed of Tripterygium wilfordii Hook. f. 55g, Wolfsbane 30g, Serratula wolongensis 40g, Wolfsbane 15g, water-willow root 20g and chestnut shell 8g.

[0146] Preparation method: according to the above weight, wash the Tripterygium wilfordii Hook. f, Selaginella tamariscina (Desv.) Spring and water oen root with clean water, add 2 times the amount of water to soak for 10 minutes, then decoct, the first decocting 1 hour, filter to obtain the filtrate; the dregs are added with 3 times the amount of water to decoct for 1.5 hours, filter to obtain the filtrate, combine the two filtrates, filter, centrifugal separation of the filtrate, centrifugal separation at 3000 rpm, separate to obtain the supernatant A; the rest of the Senecio scandens Buch.-Ham., Aquilegia viridiflora and chestnut shell are washed, soaked with 9 times the amount of water for 45 minutes, then decoct, the first decocting 3 hours, filter to obtain the filtrate, the dregs are added with 1 times the amount of water to decoct for 0.5 hours, filter to obtain the filtrate, combine the two filtrates, filter, concentrate the filtrate to 70 DEG C, measure the relative density of 1.15-1.18, add ethanol to make the alcohol content reach 65%, stand, take the supernatant to recover ethanol for standby; and concentrate to 80 DEG C, measure the relative density of 1.25-1.30 of the extract B; mix the supernatant A and the extract B uniformly, add 0.5 times the amount of water to extract at 80 DEG C for 0.5 hours, stand the medicinal liquid, take the upper clear liquid after standing to obtain the essence. The essence is sterilized and disinfected, then is filled into 100ml bottles, which can be added into warm water of 40-60 DEG C to soak the affected part or take a medicated bath, can also be used for fumigation, and can be directly sprayed on the affected part.

[0147] Example 5

[0148] The herbal essence is composed of Tripterygium wilfordii Hook. f 45g, Selaginella tamariscina (Desv.) Spring 40g, Senecio scandens Buch.-Ham. 35g, Aquilegia viridiflora 17g, water oen root 18g and chestnut shell 8g.

[0149] Preparation method: according to the above weight, wash the Tripterygium wilfordii Hook. f, Selaginella tamariscina (Desv.) Spring and water oen root with clean water, add 6 times the amount of water to soak for 30 minutes, then decoct, the first decocting 3 hours, filter to obtain the filtrate; the dregs are added with 1 times the amount of water to decoct for 0.5 hours, filter to obtain the filtrate, combine the two filtrates, filter, centrifugal separation of the filtrate, centrifugal separation at 3000 rpm, separate to obtain the supernatant A; the rest of the Senecio scandens Buch.-Ham., Aquilegia viridiflora and chestnut shell are washed, soaked with 3 times the amount of water for 15 minutes, then decoct, the first decocting 1 hour, filter to obtain the filtrate, the dregs are added with 3 times the amount of water to decoct for 1.5 hours, filter to obtain the filtrate, combine the two filtrates, filter, concentrate the filtrate to 90 DEG C, measure the relative density of 1.15-1.18, add ethanol to make the alcohol content reach 65%, stand, take the supernatant to recover ethanol for standby; and concentrate to 90 DEG C, measure the relative density of 1.25-1.30 of the extract B; mix the supernatant A and the extract B uniformly, add 1.5 times the amount of water to extract at 95 DEG C for 1.5 hours, stand the medicinal liquid, take the upper clear liquid after standing to obtain the essence. The essence is sterilized and disinfected, then is filled into 100ml bottles, which can be added into warm water of 40-60 DEG C to soak the affected part or take a medicated bath, can also be used for fumigation, and can be directly sprayed on the affected part.

[0150] Example 6

[0151] The herbal essence of the present application is composed of 40g of Trachelospermi caulis, 45g of Selaginellae herba, 30g of Senecionis herba, 20g of Ilicis rotundae cortex, 15g of Alnifoliae radix and 10g of Castaneae hul.

[0152] The preparation method is as follows: the above raw medicine is washed with clean water, soaked in 4 times of water for 20 minutes, then decocted, the first decoction is for 2 hours, the filtrate is obtained by filtration; the residue is decocted with 2 times of water for 1 hour, filtered, the filtrate is obtained, the two filtrates are combined, filtered, the filtrate is centrifuged at 3000rpm, the supernatant is separated; the supernatant is placed, the upper clear liquid is taken, and the essence is obtained.

Claims

1. A topical herbal essence that improves peeling, flaking, and epidermal cracking caused by dry skin after itching, characterized in that... The raw materials for this herbal essence consist of 20-60 parts by weight of Trachelospermum jasminoides, 22-68 parts by weight of Selaginella tamariscina, 15-45 parts by weight of Senecio scandens, 10-30 parts by weight of Aristolochia debilis, 7-23 parts by weight of Aristolochia debilis root, and 5-15 parts by weight of chestnut shell.

2. The herbal essence as described in claim 1, characterized in that, The raw materials for this herbal essence consist of 30-50 parts by weight of Trachelospermum jasminoides, 35-55 parts by weight of Selaginella tamariscina, 20-40 parts by weight of Senecio scandens, 15-25 parts by weight of Ephedra sinica, 10-20 parts by weight of Aristolochia debilis root, and 7-13 parts by weight of chestnut shell.

3. The herbal essence as described in claim 1, characterized in that, The raw materials for this herbal essence consist of 40 parts by weight of Trachelospermum jasminoides, 45 parts by weight of Selaginella tamariscina, 30 parts by weight of Senecio scandens, 20 parts by weight of Aristolochia debilis, 15 parts by weight of Aristolochia debilis root, and 10 parts by weight of chestnut shell.

4. The herbal essence as described in claim 1, characterized in that, The raw materials for this herbal essence consist of 25 parts by weight of Trachelospermum jasminoides, 60 parts by weight of Selaginella tamariscina, 20 parts by weight of Senecio scandens, 25 parts by weight of Aristolochia debilis, 10 parts by weight of Aristolochia debilis root, and 12 parts by weight of chestnut shell.

5. The herbal essence as described in claim 1, characterized in that, The raw materials for this herbal essence consist of 55 parts by weight of Trachelospermum jasminoides, 30 parts by weight of Selaginella tamariscina, 40 parts by weight of Senecio scandens, 15 parts by weight of Aristolochia debilis, 20 parts by weight of Aristolochia debilis root, and 8 parts by weight of chestnut shell.

6. The herbal essence as described in any one of claims 1-5, characterized in that, The preparation method of this herbal essence is as follows: (1) Weigh out the parts by weight of Trachelospermum jasminoides, Selaginella tamariscina and Sedum sarmentosum root, wash them with clean water, soak them in 2-6 times the amount of water for 10-30 minutes, and then decoct them. The first decoction is 1-3 hours, and the filtrate is filtered. The dregs are then decocted in 1-3 times the amount of water for 0.5-1.5 hours, filtered, and the filtrate is obtained. The two filtrates are combined, filtered, and the filtrate is centrifuged at 3000 rpm to obtain the supernatant A. (2) Wash the remaining Senecio scandens, eagle-like herbs, and chestnut shells, soak them in 3-9 times the amount of water for 15-45 minutes, then decoct them. The first decoction is 1-3 hours, filtered, and the filtrate is obtained. The dregs are then decocted in 1-3 times the amount of water for 0.5-1.5 hours, filtered, and the filtrate is obtained. The two filtrates are combined, filtered, and the filtrate is concentrated to 60-100℃ with a relative density of 1.15-1.

18. Ethanol is added to make the alcohol content reach 65%, and the mixture is allowed to stand. The supernatant is collected to recover the ethanol for later use. Extract B is concentrated to 80-90℃ with a relative density of 1.25-1.

30. (3) Mix the supernatant A and extract B evenly, add 0.5-1.5 times the amount of water at 80-100℃ and extract for 0.5-1.5 hours. Let the liquid stand, and take the clear liquid from the top layer after standing to obtain the essence.

7. The herbal essence as described in claim 6, characterized in that, The preparation method of this herbal essence is as follows: (1) Weigh out the parts by weight of Trachelospermum jasminoides, Selaginella tamariscina and Sedum sarmentosum root, wash them with clean water, soak them in 4 times the amount of water for 20 minutes, and then decoct them. The first decoction is 2 hours, and the filtrate is filtered. The dregs are then decocted in 2 times the amount of water for 1 hour, filtered, and the filtrate is obtained. The two filtrates are combined, filtered, and the filtrate is centrifuged at 3000 rpm to obtain the supernatant A. (2) Wash the remaining Senecio scandens, eagle buds and chestnut shells, soak them in 6 times the amount of water for 30 minutes, then decoct them. The first decoction is 2 hours, filtered, and the filtrate is obtained. The dregs are then decocted in 2 times the amount of water for 1 hour, filtered, and the two filtrates are combined and filtered. The filtrate is concentrated to 80℃ and the relative density is measured to be 1.15-1.

18. Ethanol is added to make the alcohol content reach 65%. The mixture is allowed to stand, and the supernatant is collected to recover the ethanol for later use. Extract B is concentrated to 85℃ and the relative density is measured to be 1.25-1.

30. (3) Mix the supernatant A and extract B evenly, add 1 times the amount of water at 90°C and extract for 1 hour. After standing, take the clear liquid from the top layer to obtain the essence.

8. The use of the herbal extract as described in any one of claims 1-5 in the preparation of a medicine for treating peeling, flaking, and epidermal cracking caused by dry skin after pruritus.

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