Method for detecting the light emission direction of the optical fiber of a magnetic resonance guided laser interstitial thermotherapy device

Abstract

The application provides a method for detecting the light fiber light emitting direction of a magnetic resonance guided laser interstitial thermotherapy device, the device comprises a host computer and a light fiber for outputting laser to target tissue, the light fiber is a side light emitting type, the method comprises the following steps: acquiring a temperature map set containing a target region; for each temperature map in the temperature map set, determining the temperature rising direction corresponding to the temperature map; and determining the light emitting direction of the light fiber according to the temperature rising direction corresponding to the temperature map in the temperature map set. The application acquires a temperature map set, determines the temperature rising direction corresponding to each temperature map, and accurately determines the light emitting direction of the light fiber according to the temperature rising direction corresponding to the temperature map in the temperature map set, which lays a good foundation for accurate conformal ablation of the target region.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a method for detecting the optical fiber output direction of a magnetic resonance-guided laser interstitial hyperthermia device. Background Technology

[0002] Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a method that uses lasers to destroy target lesions. Optical fibers deliver light energy to the lesion, and as irradiation time increases, the temperature of the lesion rises until it reaches the temperature required for thermal ablation, thus eliminating the lesion. MRgLITT offers advantages such as minimal invasiveness, low risk, and rapid recovery, providing a new treatment option for various diseases (e.g., brain tumors, epilepsy). MRgLITT can be combined with magnetic resonance imaging (MRI) to create MRgLITT, enabling temperature monitoring of the ablation process. During laser irradiation, real-time MRI temperature imaging clearly shows the temperature changes of the lesion and surrounding tissues, providing doctors with precise control over tissue ablation.

[0003] Ablation of regular lesions uses scattering optical fibers, while ablation of irregular lesions requires lateral emission optical fibers. Precise conformal ablation of irregular lesions is achieved through the rotation and retraction of the fiber. To determine the initial direction of the lateral emission optical fiber, existing methods involve setting a positioning structure on a portion of the fiber to indicate the emission direction at the distal end. The fiber is inserted into the target area only after the initial emission angle is determined. However, this method still has several problems: 1. Consistency between the positioning structure and the emission direction increases the difficulty of product assembly and debugging. Furthermore, the positioning structure is still some distance from the lateral emission section. Due to the fiber's thinness, it is still difficult to accurately determine the emission direction at the fiber end after insertion, resulting in a certain error between the direction indicated by the positioning structure and the actual emission direction; 2. The positioning structure requires the structure to rotate along with the fiber, increasing system complexity and the failure rate; 3. The positioning structure also increases product cost.

[0004] Therefore, this invention proposes a method for detecting the optical fiber output direction of a magnetic resonance-guided laser interstitial hyperthermia device. Summary of the Invention

[0005] This invention provides a magnetic resonance-guided laser interstitial hyperthermia device and a method for detecting the light output direction of an optical fiber, in order to solve the defect in the prior art that it is difficult to accurately determine the light output direction at the end of the optical fiber.

[0006] In a first aspect, the present invention provides a method for detecting the optical fiber emission direction of a magnetic resonance-guided laser interstitial hyperthermia device, the device comprising a main unit and an optical fiber for outputting laser light to a target tissue, the optical fiber being laterally emitting light, the method comprising:

[0007] Obtain a set of temperature maps containing the target region;

[0008] For each temperature map in the set of temperature maps, determine the heating direction corresponding to that temperature map;

[0009] The light emission direction of the optical fiber is determined based on the heating direction corresponding to the temperature map in the set of temperature maps.

[0010] According to the optical fiber emission direction detection method provided by the present invention, the step of acquiring a set of temperature maps of the target area includes:

[0011] One or more temperature maps are obtained on the same plane perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, forming the temperature map set.

[0012] According to the optical fiber emission direction detection method provided by the present invention, the step of acquiring a set of temperature maps of the target area includes:

[0013] Obtain a magnetic resonance image sequence containing the target region;

[0014] A three-dimensional temperature map is generated based on the magnetic resonance image sequence;

[0015] A temperature map is obtained from the three-dimensional temperature map using the same plane that is perpendicular to the optical fiber axis and passes through the light-emitting part of the optical fiber, and then added to the temperature map set.

[0016] According to the optical fiber emission direction detection method provided by the present invention, the step of acquiring a set of temperature maps of the target area includes:

[0017] Acquire a magnetic resonance image on a target plane; the target plane is a plane perpendicular to the optical fiber axis and passing through the light-emitting portion of the optical fiber;

[0018] A corresponding temperature map is generated based on the magnetic resonance image on the target plane and added to the temperature map set.

[0019] According to the optical fiber emission direction detection method provided by the present invention, determining the heating direction corresponding to each temperature map in the temperature map set includes:

[0020] All high-temperature pixels in the first temperature map are identified; wherein, the first temperature map is any image in the set of temperature maps, and the high-temperature pixels are pixels whose temperature is not lower than a first temperature threshold.

[0021] The high-temperature region of the first temperature map is determined based on all high-temperature pixels in the first temperature map;

[0022] Based on the high-temperature region, the heating direction corresponding to the first temperature map is determined.

[0023] According to the optical fiber emission direction detection method provided by the present invention, the step of determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0024] Connect the edge pixels of the high-temperature region to the center point of the optical fiber; wherein, the center point of the optical fiber is the intersection of the central axis of the optical fiber and the plane containing the first temperature map.

[0025] The direction corresponding to the line with the most high-temperature pixels is determined as the heating direction of the first temperature map.

[0026] According to the optical fiber emission direction detection method provided by the present invention, the step of determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0027] A series of circles are generated with the center point of the optical fiber as the center; wherein, the center point of the optical fiber refers to the intersection of the central axis of the optical fiber and the plane containing the first temperature map;

[0028] Determine the circle with the largest radius that intersects the high-temperature region;

[0029] The heating direction of the first temperature map is determined based on the intersection of the circle with the largest radius and the high-temperature region of the first temperature map.

[0030] According to the optical fiber emission direction detection method provided by the present invention, the step of determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0031] Determine two tangent lines that pass through the center point of the optical fiber and are tangent to the high-temperature region; wherein, the center point of the optical fiber refers to the intersection of the central axis of the optical fiber and the plane containing the first temperature map.

[0032] The angle bisector of the two tangents is taken as the heating direction of the first temperature map.

[0033] According to the fiber optic emission direction detection method provided by the present invention, the step of determining the high-temperature region of the first temperature map based on all high-temperature pixels in the first temperature map includes:

[0034] Determine the connected components based on all high-temperature pixels in the first temperature map;

[0035] The connected region containing the most high-temperature pixels is defined as the high-temperature region of the first temperature map.

[0036] According to a fiber optic emission direction detection method provided by the present invention, the host is configured to further include, before performing the acquisition of the temperature map set of the target area:

[0037] For each temperature map, determine the number of high-temperature pixels in that temperature map;

[0038] If the number of high-temperature pixels in the temperature map is not less than a preset threshold, then the temperature map is added to the temperature map set.

[0039] According to a method for detecting the light emission direction of an optical fiber provided by the present invention, when the temperature map set contains only one temperature map, determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature map in the temperature map set includes:

[0040] The heating direction corresponding to the temperature graph is determined as the light emission direction of the optical fiber.

[0041] According to a method for detecting the light emission direction of an optical fiber provided by the present invention, when the number of temperature maps in the temperature map set is greater than one, the step of determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature maps in the temperature map set includes:

[0042] Based on the heating direction of the temperature graphs in the set of temperature graphs, determine whether the heating direction converges;

[0043] When the heating direction converges, the heating direction of the last acquired temperature map is determined as the light output direction of the optical fiber.

[0044] If the heating direction does not converge, the average value of the heating direction of the first preset number of temperature maps is taken as the light output direction of the optical fiber.

[0045] According to a method for detecting the light emission direction of an optical fiber provided by the present invention, when the temperature map set contains only a set of temperature maps on multiple parallel planes, determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature map in the temperature map set includes:

[0046] Based on the heating direction corresponding to the temperature map on each parallel plane in the temperature map set, the light output direction of the optical fiber is determined by averaging or weighted averaging.

[0047] According to a method for detecting the light emission direction of an optical fiber provided by the present invention, when the temperature map set contains more sets of temperature maps on multiple parallel planes, the step of determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature maps in the temperature map set includes:

[0048] For multiple temperature maps on each plane, determine whether the heating directions corresponding to the multiple temperature maps converge;

[0049] When the heating direction converges, the heating direction on the plane is determined based on the last temperature map obtained on the plane.

[0050] If the heating direction does not converge, the average value of the heating direction of the last second preset number of temperature maps obtained on the plane is determined as the heating direction on the plane.

[0051] The light output direction of the optical fiber is determined based on the heating direction on each plane.

[0052] According to the optical fiber emission direction detection method provided by the present invention, the criterion for determining whether the heating direction converges is as follows:

[0053] The angle of deviation of the heating direction corresponding to the third consecutive preset number of temperature charts is not greater than a preset angle threshold; wherein, the angle of deviation of the heating direction is the angle between the heating direction of each temperature chart in the third consecutive preset number of temperature charts and the heating direction of other temperature charts in the third consecutive preset number of temperature charts.

[0054] Secondly, the present invention provides a magnetic resonance-guided laser interstitial hyperthermia device host, the host comprising a memory, a processor, and a computer program stored in the memory, characterized in that the computer program is executed by the processor to perform the following steps:

[0055] Obtain a set of temperature maps containing the target region;

[0056] For each temperature map in the set of temperature maps, determine the heating direction corresponding to that temperature map;

[0057] The light emission direction of the optical fiber is determined based on the heating direction corresponding to the temperature map in the set of temperature maps.

[0058] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host, the acquisition of a set of temperature maps containing the target region includes:

[0059] One or more temperature maps are obtained on the same plane perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, forming the temperature map set.

[0060] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host, the acquisition of a set of temperature maps containing the target region includes:

[0061] A set of temperature maps is obtained on multiple parallel planes perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, forming the temperature map set.

[0062] One set of temperature maps contains one temperature map on each plane.

[0063] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host, wherein acquiring the temperature map set of the target area includes:

[0064] Obtain a magnetic resonance image sequence containing the target region;

[0065] A three-dimensional temperature map is generated based on the magnetic resonance image sequence;

[0066] A temperature map is obtained from the three-dimensional temperature map using the same plane that is perpendicular to the fiber axis and passes through a portion of the fiber, and then added to the temperature map set.

[0067] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host, wherein acquiring the temperature map set of the target area includes:

[0068] Acquire a magnetic resonance image on a target plane; the target plane is a plane perpendicular to the fiber axis and passing through a portion of the fiber.

[0069] A corresponding temperature map is generated based on the magnetic resonance image on the target plane and added to the temperature map set.

[0070] According to the present invention, in a magnetic resonance-guided laser interstitial hyperthermia device, determining the heating direction corresponding to each temperature map in the set of temperature maps includes:

[0071] All high-temperature pixels in the first temperature map are identified; wherein, the first temperature map is any image in the set of temperature maps, and the high-temperature pixels are pixels whose temperature is not lower than a first temperature threshold.

[0072] The high-temperature region of the first temperature map is determined based on all high-temperature pixels in the first temperature map;

[0073] Based on the high-temperature region, the heating direction corresponding to the first temperature map is determined.

[0074] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host, wherein determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0075] Connect the edge pixels of the high-temperature region to the center point of the optical fiber; wherein, the center point of the optical fiber is the intersection of the central axis of the optical fiber and the plane containing the first temperature map.

[0076] The direction corresponding to the line with the most high-temperature pixels is determined as the heating direction of the first temperature map.

[0077] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host, wherein determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0078] A series of circles are generated with the center point of the optical fiber as the center; wherein, the center point of the optical fiber refers to the intersection of the central axis of the optical fiber and the plane containing the first temperature map;

[0079] Determine the circle with the largest radius that intersects the high-temperature region;

[0080] The heating direction of the first temperature map is determined based on the intersection of the circle with the largest radius and the high-temperature region of the first temperature map.

[0081] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host, wherein determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0082] Determine two tangent lines that pass through the center point of the optical fiber and are tangent to the high-temperature region; wherein, the center point of the optical fiber refers to the intersection of the central axis of the optical fiber and the plane containing the first temperature map.

[0083] The angle bisector of the two tangents is taken as the heating direction of the first temperature map.

[0084] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host, wherein determining the high-temperature region of the first temperature map based on all high-temperature pixels in the first temperature map includes:

[0085] Determine the connected components based on all high-temperature pixels in the first temperature map;

[0086] The connected region containing the most high-temperature pixels is defined as the high-temperature region of the first temperature map.

[0087] According to the present invention, a magnetic resonance-guided laser interstitial hyperthermia device host is configured to further include, before performing the acquisition of the temperature map set of the target region:

[0088] For each temperature map, determine the number of high-temperature pixels in that temperature map;

[0089] If the number of high-temperature pixels in the temperature map is not less than a preset threshold, then the temperature map is added to the temperature map set.

[0090] According to the present invention, in the case that the temperature map set contains only one temperature map, determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature map in the temperature map set includes:

[0091] The heating direction corresponding to the temperature graph is determined as the light emission direction of the optical fiber.

[0092] According to the present invention, in a magnetic resonance-guided laser interstitial hyperthermia device, when the number of temperature maps in the temperature map set is greater than one, determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature maps in the temperature map set includes:

[0093] Based on the heating direction of the temperature graphs in the set of temperature graphs, determine whether the heating direction converges;

[0094] When the heating direction converges, the heating direction of the last acquired temperature map is determined as the light output direction of the optical fiber.

[0095] If the heating direction does not converge, the average value of the heating direction of the first preset number of temperature maps is taken as the light output direction of the optical fiber.

[0096] According to the present invention, the main unit of a magnetic resonance-guided laser interstitial hyperthermia device is provided, wherein the criterion for determining whether the heating direction converges is:

[0097] The angle of deviation of the heating direction corresponding to the second consecutive preset number of temperature charts is not greater than a preset angle threshold; wherein, the angle of deviation of the heating direction is the angle between the heating direction of each temperature chart in the second consecutive preset number of temperature charts and the heating direction of other temperature charts in the second consecutive preset number of temperature charts.

[0098] The present invention also provides a magnetic resonance-guided laser interstitial hyperthermia device, characterized in that it includes an optical fiber and the main unit of the magnetic resonance-guided laser interstitial hyperthermia system described in any one of the above claims;

[0099] The magnetic resonance imaging device is used to acquire a set of temperature maps containing the target region and send them to the host of the magnetic resonance-guided laser interstitial hyperthermia system.

[0100] The magnetic resonance-guided laser interstitial hyperthermia system is used to determine the light output direction of the optical fiber.

[0101] The present invention also provides a computer program product comprising computer-executable instructions, which, when executed, are used to implement all or part of the steps of any of the above-described optical fiber output direction detection methods.

[0102] This invention provides a magnetic resonance-guided laser interstitial hyperthermia device main unit and a method for detecting the light output direction of optical fibers. It acquires a set of temperature maps, determines the corresponding heating direction of each temperature map, and accurately determines the light output direction of the optical fiber based on the heating direction of the temperature maps in the set of temperature maps, thus laying a good foundation for precise conformal ablation of the target area. Attached Figure Description

[0103] To more clearly illustrate the technical solutions in this invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0104] Figure 1 This is a schematic diagram of the optical fiber end structure in existing technology;

[0105] Figure 2 This is a schematic diagram of the use of optical fibers to heat and ablate a target area in existing technology;

[0106] Figure 3 This is a schematic diagram of the main unit of the magnetic resonance-guided laser interstitial hyperthermia device provided by the present invention;

[0107] Figure 4 This is a schematic diagram of the high-temperature region of a cross section after an agar block sample is heated using optical fiber;

[0108] Figure 5 This is a schematic diagram showing the temperature rise direction of a cross-section after heating an agar block sample using optical fiber.

[0109] Figure 6 This invention provides a flowchart illustrating a method for detecting the light output direction of an optical fiber. Detailed Implementation

[0110] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions of this invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0111] To facilitate understanding of this invention, a brief description of the magnetic resonance-guided laser interstitial hyperthermia device is provided below: The magnetic resonance-guided laser interstitial hyperthermia device includes a main unit and optical fibers, and is used with the assistance of a magnetic resonance imaging (MRI) device. The puncture channel can reach the target area, and the optical fiber within the puncture channel can directionally emit laser light from its end to heat the target area. Figure 1 A schematic diagram of the optical fiber end structure in the prior art is shown (it should be noted here that...) Figure 1 The illustrative structure provided is for illustrative purposes only and does not imply that the invention must adopt the provided structure. Figure 1 The structure of the optical fiber, and the side-emitting optical fiber, both present the technical problems proposed in this invention, and the technical solutions of this invention can be applied. Figure 1 As shown, the fiber optic end includes a distal end 11 of the fiber body and a reflective surface 12. The reflective surface 12 can be disposed inside the fiber sleeve 13 that mates with the distal end 11. The light 14 transmitted within the fiber passes through the reflective surface 12 and is then reflected as light 15. Figure 2 As shown, the direction of the reflected light 15 can be adjusted by controlling the rotation of the optical fiber 10 along its central axis, thereby conformally heating the target area 16. It should be noted that the emitted light 15 is a laser beam within a certain angle range, and the center of this emission range is the emission direction of the optical fiber 10. The rotation direction of the optical fiber 10 can be adjusted as needed. Figure 2 The diagram only illustrates the state of the optical fiber rotating counterclockwise. The magnetic resonance imaging (MRI) device can acquire MRI images of the target region 16 during the heating process. The host computer can generate a temperature map containing the temperature state of the target region 16 based on the MRI images, providing information for the optical fiber heating process to adjust the fiber depth and light output direction, thereby achieving precise and complete processing of the target region 16. The aforementioned optical fiber, host computer, and MRI device constitute the MRgLITT system.

[0112] To address the problem of difficulty in determining the light emission direction at the end of an optical fiber after it has been inserted into a target area, this invention provides a magnetic resonance-guided laser interstitial hyperthermia device host, a magnetic resonance-guided laser interstitial hyperthermia device, and a method for detecting the heating direction of the optical fiber in the magnetic resonance-guided laser interstitial hyperthermia device.

[0113] The following is combined with Figures 1-6 This invention describes a magnetic resonance-guided laser interstitial hyperthermia device main unit, a magnetic resonance-guided laser interstitial hyperthermia device, and a method for detecting the fiber optic heating direction of the magnetic resonance-guided laser interstitial hyperthermia device.

[0114] Figure 3 This is a schematic diagram of the main unit of the magnetic resonance-guided laser interstitial hyperthermia device provided by the present invention, as shown below. Figure 3 The magnetic resonance-guided laser interstitial hyperthermia device includes a memory 310, a processor 320, and a computer program stored in the memory 310. The memory 310, processor 320, and communication interface 340 communicate with each other via a communication bus 330. The processor 310 acquires data via the bus 330 and executes the computer program to achieve the following steps:

[0115] STEP 1: Obtain a set of temperature maps containing the target area;

[0116] Specifically, the main unit of the magnetic resonance-guided laser interstitial hyperthermia device is the data processing center for magnetic resonance-guided laser interstitial hyperthermia. It can process the magnetic resonance images acquired by the magnetic resonance equipment and output them to the display device, providing information support for magnetic resonance-guided laser interstitial hyperthermia.

[0117] In this invention, the main unit of the magnetic resonance-guided laser interstitial hyperthermia device acquires a set of temperature maps containing the target region. The target region is the area that needs to be heated and ablated by laser output through optical fiber, such as the lesion area. Each temperature map includes the target region, but may also include other tissue regions. The temperature maps acquired based on magnetic resonance are two-dimensional temperature maps on the same tissue cross-section containing the target region of the patient. Each pixel value in the temperature map reflects the temperature at the corresponding location in that tissue cross-section. The set of temperature maps containing the target region acquired by the main unit of the magnetic resonance-guided laser interstitial hyperthermia device can be directly received or obtained by processing the received magnetic resonance images. The set of temperature maps may contain only one temperature map containing the target region, or it may contain multiple temperature maps containing the target region. It is understood that multiple temperature maps correspond to the temperatures at different locations on the same tissue cross-section containing the target region of the patient at different times. Furthermore, the aforementioned temperature map set can be temperature maps obtained during the heating and debugging process of the target area using optical fiber. Heating and debugging is not a formal heating and ablation process of the target area. Accordingly, the power of the laser output by the optical fiber during the heating and debugging process is lower than the output laser power during the formal heating process, and the (overall) temperature of the target area during the heating and debugging process is also lower than the (overall) temperature of the target area during the formal heating process.

[0118] STEP2: For each temperature map in the set of temperature maps, determine the heating direction corresponding to that temperature map;

[0119] Each temperature map corresponds to the temperature state of the same tissue section containing the target region at a given moment, and correspondingly, each temperature map can determine a specific heating direction. Specifically, due to the physical structure of the light-emitting portion, the light intensity is greater closer to the center of the light-emitting range; therefore, the center of the light-emitting range is taken as the light-emitting direction. The closer the region is to the light-emitting direction of the optical fiber, the better the heating effect; that is, the direction with the "optimal heating effect" is the heating direction of the temperature map. Therefore, the heating direction of the temperature map can be used to determine the light-emitting direction of the optical fiber. There are several ways to determine the optimal heating direction in the temperature map. For example, isotherms can be formed based on the temperature values ​​of each pixel in the temperature map, and the optimal heating direction can be determined based on the shape of the isotherms. Alternatively, the optimal heating direction can be determined based on the location of the pixel with the highest temperature, or the range of pixels in the temperature map that are above a certain temperature threshold.

[0120] STEP3. Determine the light output direction of the optical fiber based on the heating direction corresponding to the temperature map in the set of temperature maps.

[0121] Specifically, each temperature map in the temperature map set corresponds to a heating direction at a given moment. Because the heating process in the target area may be unstable, such as due to tissue inhomogeneity or differences in light transmittance and thermal conductivity, the optimal heating direction is not stable (i.e., the heating direction determined by the corresponding temperature map fluctuates over time). By using the heating direction corresponding to one or more temperature maps, the light emission direction of the optical fiber can be determined more accurately. For example, a temperature map acquired some time after the fiber outputs laser light can be used to directly determine the light emission direction based on the heating direction corresponding to that temperature map. Alternatively, the light emission direction can be determined only based on a certain number of temperature maps acquired later in the acquisition time.

[0122] It is understandable that for parallel light rays, the light output direction of the optical fiber refers to the direction of the parallel light; for light rays that emerge at a certain divergence angle, the light output direction of the optical fiber refers to the direction corresponding to the center of the divergence angle range.

[0123] In this embodiment, the main unit of the magnetic resonance-guided laser interstitial hyperthermia device acquires a set of temperature maps, determines the corresponding heating direction of each temperature map, and accurately determines the light output direction of the optical fiber based on the heating direction of the temperature map in the set of temperature maps, thus laying a good foundation for precise conformal ablation of the target area.

[0124] Based on the above embodiments, in one embodiment, obtaining a set of temperature maps containing the target area includes:

[0125] One or more temperature maps are obtained on the same cross-section perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, forming the temperature map set.

[0126] Specifically, the light-emitting direction of a side-emitting optical fiber is at 90° (or close to 90°) to the fiber's central axis. This means the light-emitting direction can be identified in a plane perpendicular to the fiber's axis and passing through its emission section. Therefore, by acquiring a temperature map of the cross-section perpendicular to the fiber's axis and passing through its emission section, the light-emitting direction can be quickly determined in that cross-section, reducing data processing workload. Furthermore, the light-emitting direction determined in this cross-section can be directly used as the basis for fiber adjustment, for example, rotating the fiber's emission direction to a predetermined initial position.

[0127] It should be noted that the laser does not emit from a single point at the end of the optical fiber; a section of the fiber at the end can emit laser light, and this section of the fiber that emits laser light is the aforementioned "light-emitting part".

[0128] Based on the above embodiments, in one embodiment, obtaining the temperature map set containing the target area includes:

[0129] A set of temperature maps is obtained on multiple parallel planes perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, forming the temperature map set.

[0130] One set of temperature maps contains one temperature map on each plane.

[0131] Specifically, temperature maps can be acquired on multiple parallel planes, each perpendicular to the fiber axis and passing through the fiber's output section. Acquiring one temperature map on each plane constitutes a set of temperature maps. For example, magnetic resonance imaging (MRI) can be used to continuously acquire MRI images on multiple parallel planes perpendicular to the fiber axis and passing through the fiber's output section, and calculate and generate the corresponding temperature maps to obtain a set of temperature maps. Furthermore, multiple acquisitions can be performed using MRI to obtain multiple sets of temperature maps on these parallel planes, which can be used to more accurately determine the fiber's output direction.

[0132] In this embodiment, by acquiring one or more sets of temperature maps on multiple parallel planes perpendicular to the optical fiber axis and passing through the optical fiber output section, the range of areas included in the calculation is expanded, thereby improving the accuracy of the optical fiber output direction.

[0133] Based on any of the above embodiments, in one embodiment, obtaining the temperature map set of the target area includes:

[0134] Obtain a magnetic resonance image sequence containing the target region;

[0135] A three-dimensional temperature map is generated based on the magnetic resonance image sequence.

[0136] A temperature map is obtained from the three-dimensional temperature map using a plane perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, and then added to the temperature map set.

[0137] Specifically, the magnetic resonance imaging (MRI) device can scan and acquire tomographic MRI images on a series of parallel planes passing through the target area. The main unit of the MRI-guided laser interstitial hyperthermia device can generate a two-dimensional temperature map at the corresponding tomographic location based on each tomographic MRI image, and then generate a three-dimensional temperature map based on the two-dimensional temperature maps at each tomographic location. Then, temperature maps are extracted from the three-dimensional temperature map using one or more parallel planes perpendicular to the fiber optic axis and passing through the fiber optic output portion, and added to the temperature map set. It is understandable that, over time, the MRI device can perform multiple image acquisitions, obtaining multiple sets of MRI image sequences, generating multiple three-dimensional temperature maps accordingly, and acquiring temperature maps on one or more parallel planes perpendicular to the fiber optic axis and passing through the fiber optic output portion.

[0138] This embodiment does not require deliberate adjustment of the scanning parameters of the magnetic resonance equipment. By generating a comprehensive three-dimensional temperature map, the acquired temperature data is more complete. The temperature map obtained from the three-dimensional temperature map is determined by a plane perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, which facilitates the determination of the light-emitting direction of the optical fiber.

[0139] Based on any of the above embodiments, in one embodiment, obtaining the temperature map set of the target area includes:

[0140] Acquire a magnetic resonance image on a target plane; the target plane is one or more parallel planes that are perpendicular to the optical fiber axis and pass through the light-emitting portion of the optical fiber.

[0141] A corresponding temperature map is generated based on the magnetic resonance image on the target plane and added to the temperature map set.

[0142] Specifically, the position of the optical fiber can be monitored (e.g., by using a magnetic resonance imaging (MRI) device or an optical / electromagnetic tracking device to track the fiber's position). Based on the detected fiber position, the scanning parameters of the MRI device can be adjusted to acquire a tomographic image on a plane perpendicular to the fiber's axis and passing through the fiber's light-emitting portion. Then, the MRI-guided laser interstitial hyperthermia device can calculate and generate a corresponding temperature map based on this MRI image. It is understood that multiple MRI images of the target plane can be acquired over time, resulting in the generation of multiple temperature maps for that target plane.

[0143] In this embodiment, by adjusting the scanning parameters of the magnetic resonance device, a magnetic resonance image on a plane perpendicular to the optical fiber axis and passing through the optical fiber output section is obtained, and a corresponding temperature map is generated. With a small amount of computation, the temperature map used to determine the optical fiber output direction can be obtained conveniently and quickly.

[0144] Based on any of the above embodiments, in one embodiment, determining the heating direction corresponding to each temperature map in the temperature map set includes:

[0145] All high-temperature pixels in the first temperature map are identified; wherein, the first temperature map is any image in the set of temperature maps, and the high-temperature pixels are pixels whose temperature is not lower than a first temperature threshold.

[0146] The high-temperature region of the first temperature map is determined based on all high-temperature pixels in the first temperature map;

[0147] Based on the high-temperature region, the heating direction corresponding to the first temperature map is determined.

[0148] Specifically, the first temperature map is any map in the set of temperature maps. The following uses the first temperature map to illustrate the process of determining the heating direction corresponding to the temperature map: First, high-temperature pixels in the first temperature map are selected based on a first temperature threshold. Pixels with temperatures not lower than the first temperature threshold are determined as high-temperature pixels, and pixels with temperatures lower than the first temperature threshold are determined as basic pixels. Based on the connected components formed by the high-temperature pixels, the high-temperature region can be determined, referring to... Figure 4 , Figure 4 This diagram illustrates a high-temperature region on a cross-section of an agar block sample heated using an optical fiber. Point p is the center point of the optical fiber on this cross-section (the intersection of the fiber's central axis and the cross-section). A is the high-temperature region highlighted after processing. The temperature of each pixel in the high-temperature region is not lower than a first temperature threshold. The center point p of the optical fiber is not directly connected to the high-temperature region B because the optical fiber is not directly in the target region; it is inside a sleeve, and the laser passes through the sleeve to enter the target region. The shape of the high-temperature region can be used to determine which direction has more high-temperature pixels. Based on the center point of the optical fiber and the shape of the high-temperature region, the heating direction corresponding to the first temperature map can be determined.

[0149] The first temperature threshold can be set according to the background temperature of the target area to be processed. For example, in a specific instance, it is necessary to ablate an intracranial tumor by outputting laser through an optical fiber. Based on the intracranial background temperature of 37°C, the temperature rise is increased by 4°C, that is, the first temperature threshold is set to 41°C. Accordingly, pixels with a temperature of not less than 41°C in the temperature map are considered high-temperature pixels.

[0150] It should be noted that the terms "high-temperature pixel" and "basic pixel" are used only to distinguish pixel classification names and have no other physical meaning.

[0151] In this embodiment, high-temperature pixels are selected to identify high-temperature regions, and the heating direction is accurately determined based on these regions.

[0152] Based on any of the above embodiments, in one embodiment, determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0153] Connect the edge pixels of the high-temperature region to the center point of the optical fiber; wherein, the center point of the optical fiber is the intersection of the central axis of the optical fiber and the plane containing the first temperature map.

[0154] The direction corresponding to the line with the most high-temperature pixels is determined as the heating direction of the first temperature map.

[0155] Specifically, the laser beam exits from the fiber optic output section, passes through the sleeve, and enters the target area, heating it. The high-temperature region is the area heated to a certain temperature. (Refer to...) Figure 5 , Figure 5 This is a schematic diagram showing the heating direction of a cross-section of an agar block sample heated by optical fiber. Point p is the intersection of the fiber's central axis and the plane containing the temperature map, which is also the fiber's center point. The area circled by edge line B is the high-temperature region. Lines are drawn connecting the fiber's center point p to the edge pixels on the edge B of the high-temperature region. The number of high-temperature pixels on these lines is counted; more high-temperature pixels on a line indicate a better heating effect in that direction. The direction corresponding to the line with the most high-temperature pixels is determined as the heating direction of the first temperature map. Figure 5 The L in the figure corresponds to the direction of heating.

[0156] In this embodiment, the edge pixels of the high-temperature region are connected to the center point of the optical fiber, and the heating direction in the temperature map is accurately determined by counting the number of high-temperature pixels on the connection line.

[0157] Based on any of the above embodiments, in one embodiment, determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0158] A series of circles are generated with the center point of the optical fiber as the center; wherein, the center point of the optical fiber refers to the intersection of the central axis of the optical fiber and the plane containing the first temperature map;

[0159] Determine the circle with the largest radius that intersects the high-temperature region;

[0160] The heating direction of the first temperature map is determined based on the intersection of the circle with the largest radius and the high-temperature region of the first temperature map.

[0161] Specifically, the closer to the light output direction of the optical fiber, the better the heating effect and the wider the heating range in that direction. The center point of the optical fiber refers to the intersection of the optical fiber's central axis and the plane containing the first temperature map. In the first temperature map, a series of circles with different radii are generated with the optical fiber center point as the center. The heating range is determined by the intersection of the circles with the high-temperature region. The heating direction of the first temperature map is determined by the intersection of the farthest heating range (the radius of the largest circle) with the high-temperature region. For example, circles with radii increasing from small to large are generated in an arithmetic progression, and the circle with the largest radius intersecting the high-temperature region is determined. The circle with the largest radius intersecting the high-temperature region may have two intersection points with the edge of the high-temperature region. In this case, the heating direction is determined based on these two intersection points (such as by taking the midpoint). The circle with the largest radius may also have only one intersection point with the edge of the high-temperature region (i.e., exactly tangent). In this case, the direction of the line connecting the optical fiber center point and this intersection point is directly determined as the heating direction. For example, the radius is continuously adjusted until the circle with the largest radius intersecting the high-temperature region is determined. When the circle intersects the high-temperature region (edge) at two points, the radius of the circle is increased. When the circle does not intersect the high-temperature region (edge), the radius of the circle is decreased (using the previous circle with two intersection points as a reference, the reduced radius is not less than the radius of the previous circle), until a circle with only one intersection point is determined. This circle is the circle with the largest radius intersecting the high-temperature region, and the direction of the line connecting the center point of the optical fiber to this intersection point is the heating direction.

[0162] This embodiment accurately determines the heating direction of the temperature map by generating a series of circles.

[0163] Based on any of the above embodiments, in one embodiment, determining the heating direction corresponding to the first temperature map based on the high-temperature region includes:

[0164] Determine two tangent lines that pass through the center point of the optical fiber and are tangent to the high-temperature region;

[0165] The angle bisector of the two tangents is taken as the heating direction of the first temperature map.

[0166] Specifically, the heating effect on both sides of the light-emitting direction is basically symmetrical, that is, the high-temperature region can be considered to be symmetrical on both sides of the heating direction. Based on this, two tangent lines passing through the center point of the optical fiber and tangent to the high-temperature region are determined, and the angle bisector of the two tangent lines is taken as the heating direction of the first temperature map.

[0167] In this embodiment, the bisector of the intersection of two tangents passing through the center point of the optical fiber and tangent to the high-temperature region is used as the heating direction of the temperature map, which conveniently and quickly determines the heating direction of the temperature map.

[0168] Based on any of the above embodiments, in one embodiment, determining the high-temperature region of the first temperature map based on all high-temperature pixels in the first temperature map includes:

[0169] Determine the connected components based on all high-temperature pixels in the first temperature map;

[0170] The connected region containing the most high-temperature pixels is defined as the high-temperature region of the first temperature map.

[0171] Specifically, in the process of determining the high-temperature region of the first temperature map, connected component analysis is first performed on all high-temperature pixels to obtain each connected component in the first temperature map. Then, the connected component with the most high-temperature pixels (that is, the connected component with the largest area) is determined as the high-temperature region of the first temperature map, thereby eliminating noise interference and preventing noise pixel images from being used to determine the heating direction in the future.

[0172] Based on any of the above embodiments, in one embodiment, the host is configured to further include, before performing the acquisition of the temperature map set of the target area:

[0173] For each temperature map, determine the number of high-temperature pixels in that temperature map;

[0174] If the number of high-temperature pixels in the temperature map is not less than a preset threshold, then the temperature map is added to the temperature map set.

[0175] Specifically, for each temperature map generated from the magnetic resonance image, the number of high-temperature pixels in the temperature map is determined. When the number of high-temperature pixels is small, it indicates that the heating effect of the optical fiber on the target area has not yet been demonstrated, and the determined heating direction is not accurate enough. Therefore, the temperature map is not added to the temperature map set. When the number of high-temperature pixels is not less than the preset threshold, it indicates that the optical fiber has already achieved a certain heating effect on the target area. Therefore, the temperature map can be added to the temperature map set to further determine the heating direction.

[0176] In this embodiment, the accuracy of determining the direction of fiber heating is improved by judging the number of high-temperature pixels in the temperature map and deciding whether to add the temperature map to the temperature map set.

[0177] Based on any of the above embodiments, in one embodiment, the host is configured to further include, before performing the acquisition of the temperature map set of the target area:

[0178] For each temperature map, determine the number of high-temperature pixels in that temperature map;

[0179] If the number of high-temperature pixels in the temperature map is less than a preset threshold, then all temperature maps whose generation time is before that temperature map in the temperature map set are deleted from the temperature map set.

[0180] Specifically, when the number of high-temperature pixels in a temperature map is less than a preset threshold, while the number of temperature maps generated before that temperature map is not less than the preset threshold, it indicates that the overall temperature of the target area has decreased. The optical fiber has paused heating the target area, possibly preparing for the next stage of debugging / heating. Adjustments to the optical fiber position (depth, direction) are needed. The previously generated temperature maps are no longer suitable for determining the optical fiber's light output direction and are therefore removed from the temperature map set. Furthermore, for the main unit of a magnetic resonance-guided laser interstitial hyperthermia device, the number of image storage locations can be preset only in the main unit, for example, only three image storage locations can be set, meaning only the most recently acquired preset number of temperature maps that meet the requirements can be stored.

[0181] In this embodiment, when the number of high-temperature pixels in the temperature map is less than a preset threshold, all temperature maps whose generation time is before that temperature map in the temperature map set are deleted from the temperature map set, thus avoiding interference from invalid historical data in determining the optical fiber output direction.

[0182] Based on any of the above embodiments, in one embodiment, when the temperature map set contains only one temperature map, determining the light emission direction of the optical fiber according to the heating direction corresponding to the temperature map in the temperature map set includes:

[0183] The heating direction corresponding to the temperature graph is determined as the light emission direction of the optical fiber.

[0184] Specifically, if the temperature map set contains only one temperature map, the heating direction corresponding to that temperature map is directly determined as the heating direction of the optical fiber. For example, in scenarios where the optical fiber heats the target area for a preset time, and the heating effect stabilizes, a magnetic resonance image of the target area is acquired using a magnetic resonance imaging device, and a temperature map is calculated and generated. The heating direction corresponding to this temperature map is then directly determined as the light emission direction of the optical fiber.

[0185] In this embodiment, the light output direction of the optical fiber is conveniently and quickly determined based on only one temperature map.

[0186] Based on any of the above embodiments, in one embodiment, when the number of temperature maps in the temperature map set is greater than one, determining the light emission direction of the optical fiber according to the heating direction corresponding to the temperature maps in the temperature map set includes:

[0187] Based on the heating direction of the temperature graphs in the set of temperature graphs, determine whether the heating direction converges;

[0188] When the heating direction converges, the heating direction of the last acquired temperature map is determined as the light output direction of the optical fiber.

[0189] If the heating direction does not converge, the average value of the heating direction of the first preset number of temperature maps is taken as the light output direction of the optical fiber.

[0190] Specifically, when the number of temperature maps in the temperature map set is greater than one, the light emission direction of the optical fiber needs to be determined by combining the heating directions of each temperature map. It is understandable that the longer the duration, the more stable the heating effect in the target area, and therefore, it is necessary to use the temperature maps acquired later in time to determine the light emission direction of the optical fiber. First, it is determined whether the heating directions corresponding to the temperature maps acquired in chronological order converge. If they converge, the heating direction of the last acquired temperature map in the set is determined as the light emission direction of the optical fiber. If they do not converge, the average of the heating directions of the last first preset number of temperature maps is used to determine the light emission direction of the optical fiber. The first preset number is a preset constant, such as 3. Accordingly, in the case of non-convergence, the average of the heating directions of the last three temperature maps needs to be used to determine the light emission direction of the optical fiber.

[0191] In this embodiment, the light output direction of the optical fiber is determined by judging whether the heating direction converges, thereby further improving the accuracy of the determined light output direction of the optical fiber.

[0192] Based on any of the above embodiments, in one embodiment, when the temperature map set contains only a set of temperature maps on multiple parallel planes, determining the light emission direction of the optical fiber according to the heating direction corresponding to the temperature map in the temperature map set includes:

[0193] Based on the heating direction corresponding to the temperature map on each parallel plane in the temperature map set, the light output direction of the optical fiber is determined by averaging or weighted averaging.

[0194] Specifically, a set of temperature maps includes one temperature map on each parallel plane, and each temperature map corresponds to a heating direction. Based on the heating directions of the temperature maps on each parallel plane, the light output direction of the optical fiber is determined by weighting or averaging. For example, if temperature maps are obtained on three mutually parallel planes, with the top plane having a weight of 0.3 and a heating direction angle of 34°, the middle plane having a weight of 0.4 and a heating direction angle of 35°, and the bottom plane having a weight of 0.3 and a heating direction angle of 37°, then the heating direction of the optical fiber is determined to be (34° × 0.3) + (35° × 0.4) + (37° × 0.3) = 34.8°.

[0195] Based on any of the above embodiments, in one embodiment, when the temperature map set contains more sets of temperature maps on multiple parallel planes, determining the light emission direction of the optical fiber according to the heating direction corresponding to the temperature map in the temperature map set includes:

[0196] For multiple temperature maps on each plane, determine whether the heating directions corresponding to the multiple temperature maps converge;

[0197] When the heating direction converges, the heating direction on the plane is determined based on the last temperature map obtained on the plane.

[0198] If the heating direction does not converge, the average value of the heating direction of the last second preset number of temperature maps obtained on the plane is determined as the heating direction on the plane.

[0199] The light output direction of the optical fiber is determined based on the heating direction on each plane.

[0200] Specifically, if more sets of temperature maps (e.g., n sets) are obtained on the parallel plane, then n temperature maps are obtained on each plane. For a plane, it is determined whether the heating direction converges based on the heating direction corresponding to the n temperature maps within that plane. If the heating direction converges, then the heating direction corresponding to the last obtained temperature map among the n temperature maps of that plane is determined as the heating direction corresponding to that plane. If the heating direction does not converge, then the average value of the heating directions of the last obtained second preset number of temperature maps is determined as the heating direction corresponding to that plane. Finally, the light output direction of the optical fiber is determined based on the heating direction corresponding to each plane. For example, multiple temperature maps were obtained on three mutually parallel planes. The top plane has a weight of 0.25, and the heating direction deviation angle on that plane is determined to be 43.8°. The middle plane has a weight of 0.5, and the heating direction deviation angle on that plane is determined to be 44.3°. The bottom plane has a weight of 0.25, and the heating direction deviation angle on that plane is determined to be 45.2°. Therefore, the heating direction of the optical fiber is determined to be (44.8°×0.25)+(44.4°×0.5)+(45.2°×0.25)=44.7°.

[0201] In this embodiment, based on multiple temperature maps on multiple parallel planes, the convergence status in each plane is judged to determine the heating direction in the plane, and then the light output direction of the optical fiber is accurately determined by combining the data from all planes.

[0202] Based on any of the above embodiments, in one embodiment, the condition for determining whether the heating direction converges is:

[0203] The angle of deviation of the heating direction corresponding to the third consecutive preset number of temperature charts is not greater than a preset angle threshold; wherein, the angle of deviation of the heating direction is the angle between the heating direction of each temperature chart in the third consecutive preset number of temperature charts and the heating direction of other temperature charts in the third consecutive preset number of temperature charts.

[0204] Specifically, the third preset quantity is a preset constant, such as 3. In this case, the heating direction angles corresponding to the last three temperature graphs are determined to be A. n-2 A n-1 A n The preset angle threshold is A0. If we determine |A n -A n-2 |<A0,|A n -A n-1 |<A0, and |A n-1 -A n-2 If | < A0, then the heating direction is determined to converge. The preset angle threshold can also be set according to requirements, for example, to 1°.

[0205] In this embodiment, the convergence of the heating direction of the temperature map is accurately determined by judging the deflection angle of the heating direction corresponding to the third consecutive preset number of temperature maps, which further improves the accuracy of the determined fiber heating direction.

[0206] The following describes a fiber optic light output direction detection method provided by the present invention. This fiber optic light output direction detection method is applied to the main unit of the magnetic resonance-guided laser interstitial hyperthermia device described above, and can be used in correspondence with the main unit of the magnetic resonance-guided laser interstitial hyperthermia device described above.

[0207] Figure 6 This is a flowchart illustrating a method for detecting the output direction of an optical fiber provided by the present invention, as shown below. Figure 6 As shown, the method includes:

[0208] S61. Obtain a set of temperature maps containing the target area;

[0209] Specifically, the main unit of the magnetic resonance-guided laser interstitial hyperthermia device is the data processing center for magnetic resonance-guided laser interstitial hyperthermia. It can process the magnetic resonance images acquired by the magnetic resonance equipment and output them to the display device, providing information support for magnetic resonance-guided laser interstitial hyperthermia.

[0210] In this invention, the main unit of the magnetic resonance-guided laser interstitial hyperthermia device acquires a set of temperature maps containing the target region. The target region is the area that needs to be heated and ablated by laser output through optical fiber, such as the lesion area. Each temperature map includes the target region, but may also include other tissue regions. The temperature maps acquired based on magnetic resonance are two-dimensional temperature maps on the same tissue cross-section containing the target region of the patient. Each pixel value in the temperature map reflects the temperature at the corresponding location in that tissue cross-section. The set of temperature maps containing the target region acquired by the main unit of the magnetic resonance-guided laser interstitial hyperthermia device can be directly received or obtained by processing the received magnetic resonance images. The set of temperature maps may contain only one temperature map containing the target region, or it may contain multiple temperature maps containing the target region. It is understood that multiple temperature maps correspond to the temperatures at different locations on the same tissue cross-section containing the target region of the patient at different times. Furthermore, the aforementioned temperature map set can be temperature maps obtained during the heating and debugging process of the target area using optical fiber. Heating and debugging is not a formal heating and ablation process of the target area. Accordingly, the power of the laser output by the optical fiber during the heating and debugging process is lower than the output laser power during the formal heating process, and the (overall) temperature of the target area during the heating and debugging process is also lower than the (overall) temperature of the target area during the formal heating process.

[0211] S62. For each temperature map in the set of temperature maps, determine the heating direction corresponding to that temperature map;

[0212] Each temperature map corresponds to the temperature state of the same tissue section containing the target region at a given moment, and correspondingly, each temperature map can determine a specific heating direction. Specifically, due to the physical structure of the light-emitting portion, the light intensity is greater closer to the center of the light-emitting range; therefore, the center of the light-emitting range is taken as the light-emitting direction. The closer the region is to the light-emitting direction of the optical fiber, the better the heating effect; that is, the direction with the "optimal heating effect" is the heating direction of the temperature map. Therefore, the heating direction of the temperature map can be used to determine the light-emitting direction of the optical fiber. There are several ways to determine the optimal heating direction in the temperature map. For example, isotherms can be formed based on the temperature values ​​of each pixel in the temperature map, and the optimal heating direction can be determined based on the shape of the isotherms. Alternatively, the optimal heating direction can be determined based on the location of the pixel with the highest temperature, or the range of pixels in the temperature map that are above a certain temperature threshold.

[0213] S63. Determine the light output direction of the optical fiber based on the heating direction corresponding to the temperature map in the set of temperature maps.

[0214] Specifically, each temperature map in the temperature map set corresponds to a heating direction at a given moment. Because the heating process in the target area may be unstable, such as due to tissue inhomogeneity or differences in light transmittance and thermal conductivity, the optimal heating direction is not stable (i.e., the heating direction determined by the corresponding temperature map fluctuates over time). By using the heating direction corresponding to one or more temperature maps, the light emission direction of the optical fiber can be determined more accurately. For example, a temperature map acquired some time after the fiber outputs laser light can be used to directly determine the light emission direction based on the heating direction corresponding to that temperature map. Alternatively, the light emission direction can be determined only based on a certain number of temperature maps acquired later in the acquisition time.

[0215] It is understandable that for parallel light rays, the light output direction of the optical fiber refers to the direction of the parallel light; for light rays that emerge at a certain divergence angle, the light output direction of the optical fiber refers to the direction corresponding to the center of the divergence angle range.

[0216] In this embodiment, a set of temperature maps is obtained based on the temperature, the corresponding heating direction of each temperature map is determined, and the light output direction of the optical fiber is accurately determined based on the heating direction of the temperature map in the set of temperature maps, laying a good foundation for precise conformal ablation of the target area.

[0217] Further embodiments of the fiber optic light output direction detection method provided by this invention can be understood by referring to the steps implemented by the computer program executed by the host of the magnetic resonance-guided laser interstitial hyperthermia device described above, and will not be repeated here.

[0218] On the other hand, the present invention also provides a computer program product, the computer program product including a computer program stored on a non-transitory computer-readable storage medium, the computer program including program instructions, and when the program instructions are executed by a computer, the computer is able to perform all or part of the steps of the fiber optic output direction detection methods provided above.

[0219] In another aspect, the present invention also provides a non-transitory computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements all or part of the steps of the fiber optic output direction detection methods provided above.

[0220] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate. The components shown as units may or may not be physical units; that is, they may be located in one place or distributed across multiple network units. Some or all of the modules can be selected to achieve the purpose of this embodiment according to actual needs. Those skilled in the art can understand and implement this without any creative effort.

[0221] Through the above description of the embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus necessary general-purpose hardware platforms, and of course, it can also be implemented by hardware. Based on this understanding, the above technical solutions, in essence or the part that contributes to the prior art, can be embodied in the form of a software product. This computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, magnetic disk, optical disk, etc., and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute the methods described in the various embodiments or some parts of the embodiments.

[0222] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A magnetic resonance-guided laser interstitial hyperthermia device main unit, the main unit comprising a memory, a processor, and a computer program stored in the memory, characterized in that, The computer program, executed by the processor, implements the following methods: Obtain a set of temperature maps containing the target region; For each temperature map in the set of temperature maps, determine the heating direction corresponding to that temperature map; For each temperature map in the set of temperature maps, determining the corresponding heating direction includes: All high-temperature pixels in the first temperature map are identified; wherein, the first temperature map is any image in the set of temperature maps, and the high-temperature pixels are pixels whose temperature is not lower than a first temperature threshold. The high-temperature region of the first temperature map is determined based on all high-temperature pixels in the first temperature map; Based on the high-temperature region, the heating direction corresponding to the first temperature map is determined; The light emission direction of the optical fiber is determined based on the heating direction corresponding to the temperature map in the set of temperature maps; the optical fiber is a lateral light emitter and can rotate during laser interstitial hyperthermia to heat areas in different directions.

2. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 1, characterized in that, The acquisition of the temperature map set containing the target area includes: One or more temperature maps are obtained on the same plane perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, forming the temperature map set.

3. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 1, characterized in that, The acquisition of the temperature map set containing the target area includes: A set of temperature maps is obtained on multiple parallel planes perpendicular to the optical fiber axis and passing through the light-emitting part of the optical fiber, forming the temperature map set. One set of temperature maps contains one temperature map on each plane.

4. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 1, characterized in that, Determining the heating direction corresponding to the first temperature map based on the high-temperature region includes: Connect the edge pixels of the high-temperature region to the center point of the optical fiber; wherein, the center point of the optical fiber is the intersection of the central axis of the optical fiber and the plane containing the first temperature map. The direction corresponding to the line with the most high-temperature pixels is determined as the heating direction of the first temperature map.

5. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 1, characterized in that, Determining the heating direction corresponding to the first temperature map based on the high-temperature region includes: A series of circles are generated with the center point of the optical fiber as the center; wherein, the center point of the optical fiber refers to the intersection of the central axis of the optical fiber and the plane containing the first temperature map; Determine the circle with the largest radius that intersects the high-temperature region; The heating direction of the first temperature map is determined based on the intersection of the circle with the largest radius and the high-temperature region of the first temperature map.

6. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 1, characterized in that, Determining the heating direction corresponding to the first temperature map based on the high-temperature region includes: Determine two tangent lines that pass through the center point of the optical fiber and are tangent to the high-temperature region; wherein, the center point of the optical fiber refers to the intersection of the central axis of the optical fiber and the plane containing the first temperature map. The angle bisector of the two tangents is taken as the heating direction of the first temperature map.

7. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 1, characterized in that, The step of determining the high-temperature region of the first temperature map based on all high-temperature pixels in the first temperature map includes: Determine the connected components based on all high-temperature pixels in the first temperature map; The connected region containing the most high-temperature pixels is defined as the high-temperature region of the first temperature map.

8. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 1, characterized in that, Before performing the step of obtaining the set of temperature maps containing the target region, the method further includes: For each temperature map, determine the number of high-temperature pixels in that temperature map; wherein, the high-temperature pixels are pixels whose temperature is not lower than a first temperature threshold. If the number of high-temperature pixels in the temperature map is not less than a preset threshold, then the temperature map is added to the temperature map set.

9. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 2, characterized in that, When the temperature map set contains only one temperature map, determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature map in the temperature map set includes: The heating direction corresponding to the temperature graph is determined as the light emission direction of the optical fiber.

10. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 2, characterized in that, When the number of temperature maps in the temperature map set is greater than one, determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature maps in the temperature map set includes: Based on the heating direction of the temperature graphs in the set of temperature graphs, determine whether the heating direction converges; When the heating direction converges, the heating direction of the last acquired temperature map is determined as the light output direction of the optical fiber. If the heating direction does not converge, the average value of the heating direction of the first preset number of temperature maps is taken as the light output direction of the optical fiber.

11. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 3, characterized in that, When the temperature map set contains only one set of temperature maps on multiple parallel planes, determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature map in the temperature map set includes: Based on the heating direction corresponding to the temperature map on each parallel plane in the temperature map set, the light output direction of the optical fiber is determined by averaging or weighted averaging.

12. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to claim 3, characterized in that, When the temperature map set contains multiple sets of temperature maps on multiple parallel planes, determining the light emission direction of the optical fiber based on the heating direction corresponding to the temperature maps in the temperature map set includes: For multiple temperature maps on each plane, determine whether the heating directions corresponding to the multiple temperature maps converge; When the heating direction converges, the heating direction on the plane is determined based on the last temperature map obtained on the plane. If the heating direction does not converge, the average value of the heating direction of the last second preset number of temperature maps obtained on the plane is determined as the heating direction on the plane. The light output direction of the optical fiber is determined based on the heating direction on each plane.

13. The main unit of the magnetic resonance-guided laser interstitial hyperthermia device according to any one of claims 10 or 12, characterized in that, The criterion for determining whether the heating direction converges is: The angle of deviation of the heating direction corresponding to the third consecutive preset number of temperature charts is not greater than a preset angle threshold; wherein, the angle of deviation of the heating direction is the angle between the heating direction of each temperature chart in the third consecutive preset number of temperature charts and the heating direction of other temperature charts in the third consecutive preset number of temperature charts.

14. A magnetic resonance-guided laser interstitial hyperthermia device, characterized in that, It includes optical fibers and the main unit of the magnetic resonance-guided laser interstitial hyperthermia device as described in any one of claims 1-13.

Images