A traditional Chinese medicine composition, a preparation method and application and a nutritional medicinal diet and a preparation method

Abstract

The present application provides a kind of traditional Chinese medicine composition, preparation method and application and a kind of nutritional medicinal diet and preparation method, belong to traditional Chinese medicine processing technical field.The present application provides a kind of traditional Chinese medicine composition, including the following weight parts of raw materials: morchella, jujube, Chinese wolfberry, gordon euryale seed, Chinese yam, lotus seed, phyllanthus emblica, dried tangerine or orange peel and poria cocos;Or morchella, licorice, jujube, astragalus, ginseng, angelica and cordyceps militaris.The present application is mixed with the traditional Chinese medicine composition, lean meat / ribs and water stewing 30-60 minutes, turn off the fire and add 4-8g salt seasoning to obtain nutritional medicinal diet.The present application makes nutritional package with medicinal value mushroom by traditional Chinese medicinal materials of medicine and food homology, contains rich vitamins and minerals, can benefit qi and nourish blood, invigorating the spleen and generating body fluid, invigorating the spleen and nourishing the skin, has very important effect on human health.And product does not add any condiment soup product can be meat or vegetable, thin but not light, thick but not greasy.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of traditional Chinese medicine processing, and particularly relates to a traditional Chinese medicine composition, a preparation method and application, and a nutritional medicinal diet and a preparation method. BACKGROUND

[0002] Modern social life is fast-paced, and work pressure is large, often making people in a sub-health state, making people vulnerable to disease. In addition, due to the overloading of the brain and physical labor of contemporary society, people often stay up late, increasing the consumption of the body, so there are generally weak constitution, lack of blood, malnutrition, loss of appetite, spiritual atrophy, fatigue, and other manifestations.

[0003] People often take medicine to achieve the effect of relieving adverse manifestations, but drugs can have side effects on the human body on the one hand, and can only be taken for a short period of time, quickly producing a therapeutic effect in the short term, and are not conducive to long-term conditioning and recovery of the body. Therefore, a traditional Chinese medicine composition and medicinal diet need to be developed to combine food and traditional Chinese medicine to achieve the effect of health care. SUMMARY

[0004] Therefore, the purpose of the present application is to provide a traditional Chinese medicine composition, a preparation method and application, and a nutritional medicinal diet and a preparation method, which overcome the inconvenience of conditioning with drugs and the problem of drug side effects.

[0005] In order to achieve the above-mentioned purpose of the application, the present application provides the following technical solutions:

[0006] The present application provides a traditional Chinese medicine composition, comprising the following raw materials by weight: 10-15 parts of Morchella, 1-5 parts of jujube, 3-5 parts of wolfberry, 2-5 parts of Galla chinensis, 6-8 parts of yam, 5-10 parts of lotus seed, 3-6 parts of Phyllanthus emblica, 5-8 parts of dried tangerine or orange peel, and 12-15 parts of Poria cocos;

[0007] Or 10-15 parts of Morchella, 12-18 parts of licorice, 1-5 parts of jujube, 15-25 parts of Astragalus, 5-10 parts of ginseng, 4-6 parts of Angelica sinensis, and 5-10 parts of Cordyceps militaris.

[0008] The present application also provides a preparation method of the traditional Chinese medicine composition, comprising the following steps:

[0009] 1) The raw materials are ultra-finely ground to 50-70 mesh, and mixed with 5-20 times the weight of water to decoct 2-3 times, and the decoction liquid and dregs are obtained by filtration;

[0010] 2) The filtered dregs, 4-7 times the weight of water of the raw materials, 9-11% of the weight of the raw materials of sucrose, and lactic acid bacteria are mixed and fermented, and the fermented extract is obtained by centrifugal filtration;

[0011] 3) mixing the decoction liquid and the fermentation extraction liquid, and spray drying to obtain the traditional Chinese medicine composition.

[0012] Preferably, the temperature of the decoction in step 1) is 80-100℃, and the decoction time is 20-40 min.

[0013] Preferably, the inoculation amount of the lactic acid bacteria in step 2) is 5×10 6 ~ 6×10 6 CFU / mL.

[0014] Preferably, the fermentation temperature is 40-42℃, and the fermentation time is 1-3 days.

[0015] Preferably, the inlet air temperature of the spray drying is 150-170℃, and the outlet air temperature is 90-110℃.

[0016] The application also provides the use of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method in the preparation of a medicine for tonifying qi and nourishing blood / spleen.

[0017] The application also provides a nutritional medicinal diet comprising the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method.

[0018] The application also provides a preparation method of the nutritional medicinal diet, characterized by comprising the following steps:

[0019] Mixing the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method, lean meat / bone and water, and stewing for 30-60 min, then adding 4-8 g of salt for seasoning.

[0020] Preferably, the mass / volume ratio of the traditional Chinese medicine composition, lean meat / bone and water is 30-40 g: 450-550 g: 800-1000 mL.

[0021] Compared with the prior art, the application has the following beneficial effects:

[0022] The application combines each component of Morchella esculenta, Jujube, Fructus Lycii, Euryale, Chinese yam, Lotus seed, Phyllium, Pericarpium Citri Reticulatae and Poria cocos, and the combination has the effects of invigorating the spleen and nourishing the skin, clearing heat and reducing dryness, and diuresis, and is suitable for sub-health people with long-term malnutrition and high pressure, and people with dark skin, insomnia, long spots and endocrine disorders. The application combines each component of Morchella esculenta, licorice, Jujube, Astragalus, ginseng, angelica and Cordyceps militaris, and the combination has the effects of tonifying qi and nourishing blood, invigorating the spleen and generating fluid, and is suitable for people with deficiency of both qi and blood, and can be used to relieve symptoms caused by long-term disease, such as qi deficiency, blood deficiency or deficiency of both qi and blood.

[0023] The present application usually adds the Chinese medicinal material with the same medicinal and edible effects to the food material, and makes the nutritional package by using the mushroom with medicinal value, which contains rich vitamins and minerals, can benefit qi and blood, invigorate the spleen and produce saliva, invigorate the spleen and beautify the complexion, and has very important effect on human health. And the product does not add any condiment, and the soup prepared by simmering can be meat or vegetarian, thin but not bland, thick but not greasy.

[0024] The present application makes the particle size of the medicinal material reach the cell crushing level by supermicro grinding, so that the effective components between and in the cells of the medicine are directly released, the dissolution speed and dissolution rate of the effective components in the medicine are improved, the effective components in the medicinal residue can be reused by fermentation of the medicinal residue, the bitter taste and the residues of heavy metals and pesticides of the traditional Chinese medicine are reduced, the release and dissolution of the effective components of the traditional Chinese medicine soup package in the stewing process are facilitated, and the nutrition and taste of the medicinal diet are ensured. DETAILED DESCRIPTION

[0025] The present application provides a traditional Chinese medicine composition, which comprises the following raw materials in parts by weight: 10-15 parts of Morchella esculenta, 1-5 parts of Jujube, 3-5 parts of Fructus Lycii, 2-5 parts of Semen Euryale, 6-8 parts of Dioscorea, 5-10 parts of Lotus seed, 3-6 parts of Phyllanthus emblica, 5-8 parts of Pericarpium Citri Reticulatae Viride and 12-15 parts of Poria cocos.

[0026] In the present application, the amount of Morchella esculenta is preferably 12-14 parts; Morchella esculenta is sweet, and is neutral; it is distributed in the spleen and stomach meridian; it has the effects of harmonizing the stomach and promoting digestion, regulating qi and reducing phlegm; it is mainly used for indigestion and excessive phlegm and cough.

[0027] The amount of Jujube is preferably 2-4 parts; Jujube is sweet and warm; it is distributed in the spleen and stomach meridian; it has the effects of tonifying the spleen and stomach, benefiting qi and blood, calming the heart, regulating the ying and wei, and harmonizing drugs; it is mainly used for deficiency of the spleen and stomach, deficiency of qi and blood, less food and loose stool, lassitude and debility, palpitation and insomnia, and restlessness of women.

[0028] The amount of Fructus Lycii is preferably 4 parts; Fructus Lycii is neutral and sweet; it has the effects of nourishing the liver and kidney, and benefiting essence and vision; it is used for deficiency of essence, soreness of waist and knees, dizziness and tinnitus, internal heat and polydipsia, blood deficiency and emaciation, and blurred vision.

[0029] The amount of Semen Euryale is preferably 3-4 parts; Semen Euryale is sweet and astringent, and is neutral; it is distributed in the spleen and kidney meridian; it has the effects of benefiting the kidney and astringing essence, tonifying the spleen and stopping diarrhea, and eliminating dampness and stopping leucorrhea; it is used for dream and seminal emission, frequent micturition, chronic diarrhea due to spleen deficiency, leucorrhea and leukorrhagia.

[0030] The amount of Dioscorea is preferably 7 parts; Dioscorea is sweet and neutral; it is distributed in the spleen, lung and kidney meridian; it has the effects of tonifying the spleen and stomach, producing saliva and benefiting the lung, and tonifying the kidney and astringing essence; it is used for spleen deficiency and less food, chronic diarrhea, lung deficiency and cough, kidney deficiency and seminal emission, leukorrhagia and frequent micturition, and heat due to deficiency.

[0031] The amount of Lotus seed is preferably 6-9 parts; Lotus seed is sweet and astringent, and is neutral; it has the effects of tonifying the spleen and stopping diarrhea, and nourishing the heart and kidney.

[0032] The amount of the Phyllanthus emblica is preferably 4-5 parts; the Phyllanthus emblica is bitter, sweet and sour, and cold in nature; it has the effects of clearing heat and benefiting the throat, moistening the lung and reducing phlegm, and relieving thirst;

[0033] The amount of the Pericarpium Citri Reticulatae Viride is preferably 13-17 parts; the Pericarpium Citri Reticulatae Viride is bitter and acrid, and warm in nature; it is attributed to the spleen and lung meridians; it has the effects of regulating qi and invigorating the spleen, and drying dampness and reducing phlegm;

[0034] The amount of the Poria cocos is preferably 13-14 parts; the Poria cocos is sweet and bland, and warm in nature; it is mild in flavor; it has the effects of promoting urination, benefiting the spleen and stomach, and calming the heart and soothing the nerves; it is used to treat dysuria, edema, phlegm, cough, vomiting, diarrhea, spermatorrhea, stranguria, palpitation, and amnesia;

[0035] Or 10-15 parts of Morchella, 12-18 parts of licorice, 1-5 parts of jujube, 15-25 parts of Astragalus, 5-10 parts of ginseng, 4-6 parts of angelica, and 5-10 parts of cordyceps militaris.

[0036] In the present application, the amount of the Morchella is preferably 12-14 parts; the Morchella is sweet and bland, and is attributed to the spleen and stomach meridians; it has the effects of regulating qi and reducing phlegm; it is used to treat indigestion and excessive phlegm and cough;

[0037] The amount of the licorice is preferably 6-7 parts; the licorice is sweet and bland, and is attributed to the heart, lung, spleen, and stomach meridians; it has the effects of tonifying the spleen and invigorating qi, clearing heat and detoxifying, expelling phlegm and relieving cough, relieving pain, and regulating various drugs; it is used to treat weakness of the spleen and stomach, fatigue, palpitation, shortness of breath, cough with excessive phlegm, abdominal and limb pain, carbuncle and sore, and drug toxicity and virulence;

[0038] The amount of the jujube is preferably 2-4 parts; the jujube is sweet and warm, and is attributed to the spleen and stomach meridians; it has the effects of tonifying the spleen and stomach, invigorating qi and blood, calming the heart, regulating the ying and wei, and harmonizing the properties of drugs; it is used to treat weakness of the spleen and stomach, deficiency of qi and blood, poor appetite and loose stool, fatigue, palpitation, insomnia, and restlessness of women, and disharmony of ying and wei;

[0039] The amount of the Astragalus is preferably 18-22 parts; the Astragalus is warm in nature and sweet in flavor; it has the effects of tonifying qi, consolidating the exterior, expelling pus, promoting urination, and promoting tissue regeneration;

[0040] The amount of the ginseng is preferably 6-9 parts; the ginseng is used to treat exhaustion and deficiency, poor appetite, fatigue, regurgitation, loose stool, deficiency cough, spontaneous sweating, palpitation, amnesia, dizziness, headache, impotence, frequent urination, diabetes, metrorrhagia, slow convulsion of children, and deficiency of qi and blood;

[0041] The angelica is preferably 5 parts; angelica is sweet, pungent and bitter; warm; liver, heart and spleen meridian; has the effects of tonifying blood, activating blood, regulating menstruation and relieving pain, moistening dryness and lubricating intestines; it is used for blood deficiency, irregular menstruation, amenorrhea, dysmenorrhea, abdominal mass, collapse, cold abdominal pain, flaccid paralysis, numbness of the skin, dry and difficult bowel movement, dysentery, carbuncle, sore and injury.

[0042] The amount of cordyceps militaris is preferably 6-9 parts; cordyceps militaris sporodochia can be used as medicine, and it is flat, sweet and can benefit the lungs and kidneys, stop bleeding and reduce phlegm, and it is generally used for pulmonary tuberculosis, old and weak, anemia and other symptoms.

[0043] The application also provides a preparation method of the traditional Chinese medicine composition, comprising the following steps:

[0044] 1) The raw materials are ultra-finely ground to 50-70 meshes, and mixed with 5-20 times the weight of water to decoct 2-3 times, and the decocting liquid and dregs are obtained by filtration;

[0045] 2) The filtered dregs, 4-7 times the weight of water of the raw materials, 9-11% of the weight of sucrose of the raw materials and lactic acid bacteria are mixed for fermentation, centrifugal filtration is performed, and a fermentation extract is obtained;

[0046] 3) The decocting liquid and the fermentation extract are mixed, and spray drying is performed to obtain the traditional Chinese medicine composition.

[0047] In the application, the raw materials are ultra-finely ground to 50-70 meshes, and mixed with 5-20 times the weight of water to decoct 2-3 times, and the decocting liquid and dregs are obtained by filtration; the mesh number after grinding is preferably 55-65 meshes; the amount of water is preferably 8-17 times the weight of the raw materials; the decocting temperature is preferably 80-100°C, and further preferably 85-95°C; the decocting time is preferably 20-40 min, and further preferably 25-35 min.

[0048] In the application, the filtered dregs, 4-7 times the weight of water of the raw materials, 9-11% of the weight of sucrose of the raw materials and lactic acid bacteria are mixed for fermentation, centrifugal filtration is performed, and a fermentation extract is obtained; the amount of water is preferably 5-6 times the weight of the raw materials; the amount of sucrose is preferably 9.5-10.5% of the weight of the raw materials; the inoculation amount of lactic acid bacteria is preferably 5x10 6 ~ 6x10 6 CFU / mL; further preferably 5.2x10 6 ~ 5.8x10 6 CFU / mL; the fermentation temperature is preferably 40-42°C, and further preferably 41°C; the fermentation time is preferably 1-3 days, and further preferably 1.5-2.5 days.

[0049] In the present application, the decoction liquid and the fermentation extraction liquid are mixed, and the mixture is spray dried to obtain the traditional Chinese medicine composition; the inlet air temperature of the spray drying is preferably 150-170℃, and further preferably 155-165℃; and the outlet air temperature is preferably 90-110℃, and further preferably 95-105℃.

[0050] The present application also provides the use of the traditional Chinese medicine composition and the traditional Chinese medicine composition prepared by the preparation method in the preparation of a medicine for tonifying qi and nourishing blood / spleen and beautifying.

[0051] The present application also provides a nutritional medicinal diet comprising the traditional Chinese medicine composition and the traditional Chinese medicine composition prepared by the preparation method.

[0052] The present application also provides a preparation method of the nutritional medicinal diet, comprising the following steps:

[0053] The traditional Chinese medicine composition and the traditional Chinese medicine composition prepared by the preparation method are mixed with lean meat / ribs and water, and then stewed for 30-60 minutes, and 4-8 g of salt is added for seasoning.

[0054] In the present application, the mass / volume ratio of the traditional Chinese medicine composition, lean meat / ribs and water is preferably 30-40 g: 450-550 g: 800-1000 mL; and further preferably 32-38 g: 480-520 g: 850-950 mL; the stewing time is preferably 35-55 min; and the amount of salt is preferably 5-7 g.

[0055] The technical solutions provided by the present application will be described in detail below in combination with examples, but they should not be understood as limiting the scope of the present application.

[0056] Example 1

[0057] The present application provides a traditional Chinese medicine composition comprising the following raw materials by weight: 13 parts of Morchella esculenta, 3 parts of Jujube, 4 parts of Fructus Lycii, 4 parts of Euryale ferox, 7 parts of Dioscorea opposita, 8 parts of Nelumbinis Plumula, 5 parts of Phyllanthus emblica, 6 parts of Pericarpium Citri Reticulatae and 13 parts of Poria cocos.

[0058] The raw materials are ultra-micronized to 60 mesh, and mixed with water in an amount of 15 times the weight of the raw materials, and then decocted at 90℃ for 3 times, each for 30 min, and filtered to obtain a decoction liquid and a residue; the filtered residue, water in an amount of 5 times the weight of the raw materials, sucrose in an amount of 10% of the weight of the raw materials and lactic acid bacteria are mixed and fermented, and the inoculation amount of the lactic acid bacteria is 5.5×10 6 CFU / mL, and then centrifuged and filtered to obtain a fermentation extraction liquid; the decoction liquid and the fermentation extraction liquid are mixed, and then spray dried (inlet air temperature 160℃; outlet air temperature preferably 100℃) to obtain a traditional Chinese medicine composition (A).

[0059] The traditional Chinese medicine composition 35g, ribs 500g and 900mL water are mixed and stewed for 60 minutes, 6g of salt is added to season after the fire is turned off to obtain a nutrient medicinal meal (D).

[0060] Example 2

[0061] The present application provides a traditional Chinese medicine composition, which comprises the following raw materials by weight: 10 parts of Morchella, 1 part of Jujube, 3 parts of Medlar, 2 parts of Euryale, 6 parts of Chinese yam, 5 parts of Lotus seed, 3 parts of Phyllium, 5 parts of Tangerine or Orange Peel and 12 parts of Poria cocos.

[0062] The raw materials are ultra-finely ground to 50 mesh, and mixed with water 5 times the weight of the raw materials, and decocted twice at 80℃ for 20 minutes each time, and filtered to obtain decoction and dregs; the filtered dregs, water 4 times the weight of the raw materials, sucrose 9% of the weight of the raw materials and lactic acid bacteria are mixed for fermentation, and the inoculation amount of the lactic acid bacteria is 5x10 6 CFU / mL, centrifugal filtration to obtain a fermentation extract; the decoction and the fermentation extract are mixed, and spray dried (the inlet air temperature is 150℃, and the outlet air temperature is preferably 90℃) to obtain the traditional Chinese medicine composition (B).

[0063] The traditional Chinese medicine composition 30g, lean meat 450g and 800mL water are mixed and stewed for 30 minutes, 4g of salt is added to season after the fire is turned off to obtain a nutrient medicinal meal (E).

[0064] Example 3

[0065] The present application provides a traditional Chinese medicine composition, which comprises the following raw materials by weight: 15 parts of Morchella, 5 parts of Jujube, 5 parts of Medlar, 5 parts of Euryale, 8 parts of Chinese yam, 10 parts of Lotus seed, 6 parts of Phyllium, 8 parts of Tangerine or Orange Peel and 15 parts of Poria cocos.

[0066] The raw materials are ultra-finely ground to 70 mesh, and mixed with water 20 times the weight of the raw materials, and decocted three times at 100℃ for 40 minutes each time, and filtered to obtain decoction and dregs; the filtered dregs, water 7 times the weight of the raw materials, sucrose 11% of the weight of the raw materials and lactic acid bacteria are mixed for fermentation, and the inoculation amount of the lactic acid bacteria is 6x10 6 CFU / mL, centrifugal filtration to obtain a fermentation extract; the decoction and the fermentation extract are mixed, and spray dried (the inlet air temperature is 170℃, and the outlet air temperature is preferably 110℃) to obtain the traditional Chinese medicine composition (C).

[0067] The traditional Chinese medicine composition 40g, ribs 550g and 1000mL water are mixed and stewed for 60 minutes, 8g of salt is added to season after the fire is turned off to obtain a nutrient medicinal meal (F).

[0068] Example 4

[0069] The application provides a traditional Chinese medicine composition, which comprises the following raw materials in parts by weight: 13 parts of Morchella esculenta, 15 parts of Glycyrrhiza uralensis, 3 parts of Ziziphus jujuba, 20 parts of Astragalus membranaceus, 8 parts of Panax ginseng, 5 parts of Angelica sinensis and 8 parts of Cordyceps militaris.

[0070] The raw materials are ultra-finely ground to 60 mesh, and mixed with water in a weight ratio of 15:1, and decocted for 3 times at 90 DEG C for 30 minutes each time, and filtered to obtain decoction and residue; the filtered residue, water in a weight ratio of 5:1, sucrose in a weight ratio of 10% of the raw materials and lactic acid bacteria are mixed for fermentation, and the inoculation amount of the lactic acid bacteria is 5.5x10 6 The fermentation extract is obtained by centrifugal filtration, and the decoction and the fermentation extract are mixed and spray-dried (the inlet air temperature is 160 DEG C, and the outlet air temperature is preferably 100 DEG C) to obtain the traditional Chinese medicine composition (G).

[0071] The traditional Chinese medicine composition 35g, pork ribs 500g and 900mL water are mixed and stewed for 60 minutes, 6g of salt is added for seasoning after the fire is turned off to obtain a nutritious medicinal diet (J).

[0072] Example 5

[0073] The application provides a traditional Chinese medicine composition, which comprises the following raw materials in parts by weight: 10 parts of Morchella esculenta, 12 parts of Glycyrrhiza uralensis, 1 part of Ziziphus jujuba, 15 parts of Astragalus membranaceus, 5 parts of Panax ginseng, 4 parts of Angelica sinensis and 5 parts of Cordyceps militaris.

[0074] The raw materials are ultra-finely ground to 50 mesh, and mixed with water in a weight ratio of 5:1, and decocted for 2 times at 80 DEG C for 20 minutes each time, and filtered to obtain decoction and residue; the filtered residue, water in a weight ratio of 4:1, sucrose in a weight ratio of 9% of the raw materials and lactic acid bacteria are mixed for fermentation, and the inoculation amount of the lactic acid bacteria is 5x10 6 The fermentation extract is obtained by centrifugal filtration, and the decoction and the fermentation extract are mixed and spray-dried (the inlet air temperature is 150 DEG C, and the outlet air temperature is preferably 90 DEG C) to obtain the traditional Chinese medicine composition (H).

[0075] The traditional Chinese medicine composition 30g, lean meat 450g and 800mL water are mixed and stewed for 30 minutes, 4g of salt is added for seasoning after the fire is turned off to obtain a nutritious medicinal diet (K).

[0076] Example 6

[0077] The application provides a traditional Chinese medicine composition, which comprises the following raw materials in parts by weight: 15 parts of Morchella esculenta, 18 parts of Glycyrrhiza uralensis, 5 parts of Ziziphus jujuba, 25 parts of Astragalus membranaceus, 10 parts of Panax ginseng, 6 parts of Angelica sinensis and 10 parts of Cordyceps militaris.

[0078] The raw material is ultra-finely pulverized to 70 meshes, and mixed with water 20 times the weight of the raw material, decocted 3 times at 100℃, each time for 40 min, and filtered to obtain decoction and dregs; the filtered dregs, water 7 times the weight of the raw material, sucrose 11% of the weight of the raw material, and lactic acid bacteria are mixed and fermented, and the inoculation amount of the lactic acid bacteria is 6 x 10 6 The filtered fermentation extract is mixed with the decoction, and spray-dried (the inlet temperature is 170℃, and the outlet temperature is preferably 110℃) to obtain the traditional Chinese medicine composition (I).

[0079] The traditional Chinese medicine composition 40 g, pork ribs 550 g, and 1000 mL of water are mixed and stewed for 60 min, 8 g of salt is added to season, and a nutritious medicinal diet (L) is obtained.

[0080] Experimental Example 1

[0081] 140 volunteers with poor gastrointestinal function, 140 volunteers with poor sleep quality, and 140 volunteers with poor facial appearance are selected, and are evenly divided into 7 groups, each group having 20 people, and the experimental groups respectively take the traditional Chinese medicine compositions (A-C) prepared in Examples 1-3, and the nutritious medicinal diets (D-F); the traditional Chinese medicine compositions are taken orally once before and after breakfast each day, and each time 5 g; the nutritious medicinal diets are taken once every other day, and the soup and meat are eaten, and are continuously taken for 21 days; the control group takes soup water prepared by decocting 20 g of poria cocos, 20 g of Chinese yam, 20 g of lotus seeds, 20 g of gordon euryale seeds, and 1000 mL of water, and is taken once every other day. After 21 days, the efficacy and safety are evaluated.

[0082] 1. Efficacy test:

[0083] Effect on gastrointestinal function: after continuously taking the product, if the feeling is that the gastrointestinal function is more smooth or the appetite is enhanced, it is effective, and if the feeling is that there is no effect on the gastrointestinal function and the appetite, it is ineffective.

[0084] Effect on sleep: after continuously taking the product, if the feeling is that the sleep is significantly improved, it is effective, and if the feeling is that there is no great effect on the sleep, it is ineffective.

[0085] Effect on appearance: after continuously taking the product, if the feeling is that the spirit is more sufficient and the appearance is ruddy than before, it is effective, and if the feeling is that there is no great effect on the spirit and the appearance, it is ineffective.

[0086] Experimental results: as shown in Table 1, it can be known from Table 1 that the traditional Chinese medicine composition and the medicinal diet of the present application have a significant effect on improving and relieving symptoms such as poor gastrointestinal digestion, fatigue, and haggard appearance, and after taking, the feeling is that the gastrointestinal function is smooth, the appetite is enhanced, the sleep is better, and then the spirit is sufficient, the appearance is ruddy, and it is not easy to be tired, and the effect is better than that of traditional Sishen Decoction for invigorating the spleen and nourishing the face, regulating malnutrition, dark skin, and insomnia.

[0087] Table 1 Effect of different treatment groups on the efficacy of invigorating the spleen and nourishing the face

[0088]

[0089]

[0090] 2. Safety evaluation:

[0091] 1. Safe, no adverse reactions.

[0092] 2. Relatively safe, adverse reactions can continue to be administered without any treatment.

[0093] 3. Safety issues, moderate adverse reactions, continue to be administered after treatment.

[0094] 4. Discontinued due to adverse reactions.

[0095] Experimental results: During the experiment, no adverse reactions were found, and the safety was good.

[0096] Experimental Example 2

[0097] Animal experiment:

[0098] The model mice were given the modeling drug compound difenoxin by oral gavage to establish a mouse constipation model. The first black feces defecation time, feces particle number within 5 or 6 hours, and feces weight of the mice were determined to reflect the defecation of the model mice.

[0099] Adult male mice weighing 18-22 g were selected and divided into 5 groups, 10 mice in each group. Surgical scissors, ophthalmic forceps, ruler, syringe, balance, activated carbon powder, gum arabic, and compound difenoxin.

[0100] Preparation of ink: accurately weigh 100 g of gum arabic, add 800 mL of water, and boil until the solution is transparent. Add 50 g of activated carbon (powder) to the above solution and boil three times. After the solution cools, add water to 1000 mL and store in the refrigerator at 4°C. Shake well before use.

[0101] Preparation of compound difenoxin suspension: Compound difenoxin tablets, each containing 2.5 mg of compound difenoxin. Take the corresponding amount of compound difenoxin tablets, grind them into powder with a mortar, and then add water to 100 mL. Prepare just before use.

[0102] Dose grouping and administration time of test samples: The model mice were randomly divided into three dose groups, a blank control group, and a model control group. The low-dose group was given 2.5 times the human clinical dose of the traditional Chinese medicine composition prepared in Example 1, the medium-dose group was given 5 times the human clinical dose of the traditional Chinese medicine composition prepared in Example 1, and the high-dose group was given 10 times the human clinical dose of the traditional Chinese medicine composition prepared in Example 1. Continuous administration for 7 days.

[0103] Experimental method: after 7 days of drug administration, the animals in each group were fasted for 16 hours without water, the model control group and the three dose groups were given compound diphenoxylate suspension (7.5 mg / kg BW) by gavage, and the blank control group was given water by gavage. 0.5 hours later, the ink containing the corresponding test sample was given to each administration group (containing 5% activated carbon powder, 10% gum arabic), and the negative and model control groups were given ink by gavage. From the ink gavage, the time of the first black stool of each animal, the number and weight of black stools within 5 or 6 hours were recorded.

[0104] Experimental results: As shown in Table 2, compared with the model group, the first defecation time of each dose group of the traditional Chinese medicine composition prepared by the application and the positive control group was significantly shortened, and the number of defecation was significantly increased, which could effectively improve the gastrointestinal condition.

[0105] Table 2 Effect of composition on defecation of constipation model mice

[0106] Group Time of first defecation / min Number of defecation pellets in 3h Number of defecation pellets in 6h Control group 130.28±7.46 10.01±2.03 10.43±2.14 Model group 268.43±18.13 3.01±0.12 5.21±1.34 High-dose group 121.87±2.01 8.31±0.96 10.18±1.90 Medium-dose group 135.34±2.08 4.96±0.32 8.97±0.99 Low-dose group 140.32±4.19 3.89±0.34 5.86±0.76

[0107] Experimental example 3

[0108] Select 140 volunteers with symptoms of pale or yellowish complexion, dizziness, limb fatigue, shortness of breath, palpitation, reduced diet, pale tongue, thin white fur, weak pulse or weak pulse, etc. Among them, 120 people in the treatment group, an average of 6 groups, 20 people in each group. 20 people in the control group.

[0109] Volunteers were grouped and observed using an open, randomized, controlled method. The treatment group took the traditional Chinese medicine composition (G-I) prepared in Examples 4-6, and the nutritional medicinal diet (J-L). The traditional Chinese medicine composition was taken orally once before breakfast and once before dinner every day, 5g each time; the nutritional medicinal diet was taken once every other day, with soup and meat. The control group took Bazhen granules (3.5g*20 bags / box, GMP Z51022270, produced by Sichuan Hoban Sunshine Pharmaceutical Co., Ltd.). One bag at a time, mixed with warm water before and after breakfast and dinner. 14 days is a course of treatment, and the efficacy and safety evaluation is carried out after one course of treatment.

[0110] 1. Efficacy test:

[0111] Marked effect: Within 14 days of taking medicine, symptoms and signs improved significantly. The syndrome score decreased by ≥70%.

[0112] Effective: Within 14 days of taking medicine, symptoms and signs improved. The syndrome score decreased by ≥30%.

[0113] Ineffective: Within 14 days of taking medicine, symptoms and signs did not improve significantly, or even worsened. The syndrome score decreased by less than 30%.

[0114] Note: Calculation formula (Nimodipine method) is: [(pre-treatment score - post-treatment score) ÷ pre-treatment score] × 100%

[0115] Syndrome efficacy evaluation:

[0116] Marked effect: the symptoms or signs are reduced by 2 levels (3 points decreased to 1 point) after treatment.

[0117] Effective: the symptoms or signs are reduced by 1 level (3 points decreased to 2 points, 2 points decreased to 1 point) after treatment.

[0118] Ineffective: the symptoms or signs are not obviously improved after treatment, and the above standards are not reached.

[0119] Table 3 TCM syndrome observation score table

[0120]

[0121] Experimental results: as shown in Table 4, the traditional Chinese medicine composition and medicinal diet of the application can effectively relieve symptoms such as dizziness, pale face, shortness of breath, lazy speech, fatigue, palpitation and loss of appetite caused by deficiency of qi and blood, and have the effects of tonifying qi and blood and invigorating the spleen.

[0122] Table 4 Influence of different treatment groups on deficiency of qi and blood

[0123]

[0124]

[0125] 2. Safety evaluation:

[0126] Level 1: safe, without any adverse reactions.

[0127] Level 2: relatively safe, if there is an adverse reaction, no treatment is needed and the drug can be continued.

[0128] Level 3: there are safety problems and moderate adverse reactions, and the drug can be continued after treatment.

[0129] Level 4: the test is discontinued due to adverse reactions.

[0130] Experimental results: during the experiment, no adverse reactions were found, and the safety was good.

[0131] From the above examples and experimental examples, the present application is known that each component of Morchella, Jujube, Chinese wolfberry, Euryale, Chinese yam, lotus seed, Phyllanthus emblica, dried tangerine or orange peel and Poria cocos is matched with each other, and has the effects of invigorating the spleen, nourishing the skin, clearing away heat and reducing dryness, and diuresis, and is used for sub-health people with thin body shape, long-term malnutrition and high pressure, and people with dull complexion, insomnia and long spots, and endocrine disorders. Each component of Morchella, licorice, Jujube, Astragalus, ginseng, angelica and Cordyceps militaris is matched with each other, and has the effects of tonifying qi and nourishing blood, and invigorating the spleen and generating fluid, and is suitable for people with deficiency of both qi and blood, and can be used for relieving qi deficiency, blood deficiency or deficiency of both qi and blood caused by excessive sweating, vomiting, diarrhea or long-term illness.

[0132] The above only describes the preferred embodiments of the present application, and it should be noted that for those skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, and these improvements and refinements should also be considered as the protection scope of the present application.

Claims

1. A traditional Chinese medicine composition, characterized in that, consists of 10-15 parts of Morchella esculenta, 1-5 parts of Jujube, 3-5 parts of Fructus Lycii, 2-5 parts of Euryale ferox, 6-8 parts of Dioscorea opposita, 5-10 parts of Nelumbinis Plumula, 3-6 parts of Phyllanthus emblica, 5-8 parts of Pericarpium Citri Reticulatae Viride and 12-15 parts of Poria cocos; or 10-15 parts of Morchella esculenta, 12-18 parts of Glycyrrhiza uralensis, 1-5 parts of Jujube, 15-25 parts of Astragalus membranaceus, 5-10 parts of Panax ginseng, 4-6 parts of Angelica sinensis and 5-10 parts of Cordyceps militaris; The preparation method of the traditional Chinese medicine composition comprises the following steps: 1) the raw materials are ultra-micronized to 50-70 mesh, and the raw materials are mixed with 5-20 times the weight of water to decoct 2-3 times, and the decocting liquid and dregs are obtained by filtration; 2) the filtered dregs, 4-7 times the weight of water of the raw materials, 9-11% of the weight of the raw materials of sucrose and lactic acid bacteria are mixed to ferment, centrifuged and filtered to obtain a fermented extract; 3) the decocting liquid and the fermented extract are mixed, and spray drying is performed to obtain the traditional Chinese medicine composition.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The decocting temperature in step 1) is 80-100°C, and the decocting time is 20-40 min.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The inoculation amount of the lactic acid bacteria in Step 2) is 5 x 10 6 ~ 6 x 10 6 CFU / mL.

4. The traditional Chinese medicine composition according to claim 1, characterized in that, The fermentation temperature is 40-42°C, and the fermentation time is 1-3 days.

5. The traditional Chinese medicine composition according to claim 1, characterized in that, The inlet air temperature of the spray drying is 150-170°C, and the outlet air temperature is 90-110°C.

6. The use of the traditional Chinese medicine composition of any one of claims 1-5 in the preparation of a medicine for tonifying qi and nourishing blood / spleen and beautifying.

7. A nutraceutical meal, characterized in that, The traditional Chinese medicine composition of any one of claims 1-5.

8. The method of preparing the nutraceutical meal as claimed in claim 7, wherein, The method comprises the following steps: The traditional Chinese medicine composition of any one of claims 1-5, lean meat / ribs and water are mixed and stewed for 30-60 minutes, and 4-8 g of salt is added for seasoning.

9. The method of claim 8, wherein the nutritional pharmaceutical diet is prepared by, The mass / volume ratio of the traditional Chinese medicine composition, lean meat / ribs and water is 30-40 g: 450-550 g: 800-1000 mL.

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