A traditional Chinese medicine composition for treating gastrointestinal polyps and a preparation method thereof

Abstract

The application provides a traditional Chinese medicine composition for treating gastrointestinal polyps, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition comprises the following components in parts by mass: Bai Zhi 10-20 parts, fried ginger 10-20 parts, Dang Shen 15-45 parts, Wuzhuyu 5-15 parts, Huajiao 5-15 parts, Sheng Huairoui 10-30 parts, fried Jineijin 15-45 parts, and gluten-baked Ruodoumu 10-20 parts. The application can effectively reduce or remove existing gastrointestinal inflammatory polyps, effectively improve the clinical symptoms of gastrointestinal polyps and the imbalance state of the patient's constitution, reduce the recurrence rate of polyps, and has mild drug properties and no toxic side effects.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating gastrointestinal polyps and a preparation method thereof. BACKGROUND

[0002] Gastrointestinal polyps include gastric polyps and intestinal polyps, which are local lesions protruding from the mucosal epithelium of the gastrointestinal tract into the gastrointestinal lumen and are a common disease of the digestive tract. They are mainly caused by the hyperplasia and proliferation of the mucosal epithelial cells of the gastrointestinal tract, leading to the destruction of the normal tissue structure. According to the different parts of the digestive tract where the polyps are located, they are respectively referred to as gastric polyps, small intestinal polyps, large intestinal (colonic and rectal) polyps, etc. Among them, gastric polyps are mostly hyperplastic and inflammatory, and intestinal polyps are mostly adenomatous, which have a certain risk of cancer. Gastrointestinal polyps have no specific clinical manifestations, and some patients may have symptoms such as nausea, anorexia, indigestion, abdominal distension, diarrhea, constipation, etc. With the popularization of unhealthy eating habits, the number of cases of gastrointestinal polyps is increasing, and it has also attracted widespread attention in the field of gastroenterology.

[0003] At present, the treatment of gastrointestinal polyps is mainly through gastrointestinal polyp resection, including biopsy forceps removal, endoscopic mucosal resection or mucosal stripping, argon ion coagulation, high-frequency electric knife, etc. Among them, endoscopic mucosal stripping (ESD) has become the main method for treating gastrointestinal polyps among the majority of medical professionals. However, although ESD can completely strip the polyps, it often leaves artificial ulcers after the operation, and patients may have symptoms such as stomach pain and abdominal distension. In severe cases, complications such as delayed bleeding and perforation may occur. Studies have shown that timely removal of polyps can effectively reduce the incidence of gastrointestinal cancer, but based on the characteristics of gastrointestinal polyps being prone to recurrence, endoscopic resection of polyps cannot prevent recurrence, which causes great psychological and economic burden to patients and their families.

[0004] The term "polyp" first appeared in Huangdi Neijing (The Yellow Emperor's Classic of Internal Medicine) more than 2,000 years ago. In the chapter of Water Swelling, it is stated: "Coldness invading the outside of the intestines, the defensive qi being blocked, the qi failing to flourish, and then having something to bind, and being attached to the inside, and then the evil rising, and the polyp being generated." The causes of polyps are relatively complex, and are mainly due to improper diet, emotional internal injury, etc., leading to dysfunction of the spleen and stomach in transportation and transformation, internal generation of dampness-heat and phlegm-turbid, stagnation of qi and blood, and finally accumulation of qi, dampness, phlegm and stasis. Li Dongyuan proposed that "if the stomach is weak, the viscera and meridians will all be affected and will all be ill", so the pathogenesis of polyps is mainly summarized as weakness of the spleen and stomach as the root and mutual binding of phlegm and stasis as the branch, and the pathological factors are mainly phlegm, and are also accompanied by qi stagnation, blood stasis and dampness, and the lesion is located in the stomach and intestines, which is closely related to the spleen and stomach. A large number of studies have shown that traditional Chinese medicine has significant effects in the treatment and prevention of gastrointestinal polyps, not only can effectively reduce or remove part of the existing gastrointestinal polyps, but also can prevent the recurrence and regeneration of the removed polyps, which is economical, safe and effective, and has broad development prospects.

[0005] At present, the main treatment method of gastrointestinal polyp is under endoscope snaring, burning, removing and the like, and the treatment process has risks such as digestive tract perforation, iatrogenic ulcer, digestive tract hemorrhage and the like, and is expensive, has high recurrence rate and is painful. Therefore, a medicine with simple manufacturing process, easy to master, convenient to apply and good curative effect for treating gastrointestinal polyp still needs to be developed. SUMMARY

[0006] Therefore, the present application aims to provide a traditional Chinese medicine composition for treating gastrointestinal polyp and a preparation method thereof, so as to mainly treat the root cause and treat symptoms and root cause at the same time. The composition has the effects of warming middle energizer and strengthening spleen, drying dampness and resolving phlegm, resolving stasis and stopping bleeding and resolving stasis and resolving mass.

[0007] In order to achieve the above-mentioned application purposes, the present application provides the following technical solutions.

[0008] The present application provides a traditional Chinese medicine composition for treating gastrointestinal polyp, which comprises the following components in mass fraction:

[0009] 10-20 parts of Baizhu, 10-30 parts of Piaojiang, 15-40 parts of Dangshen, 5-15 parts of Wuzhuyu, 5-15 parts of Huajiaoshi, 10-30 parts of Chixinejin and 10-20 parts of Mutuoheimo.

[0010] Preferably, the composition comprises the following components in mass fraction:

[0011] 12-18 parts of Baizhu, 12-18 parts of Piaojiang, 20-35 parts of Dangshen, 6-12 parts of Wuzhuyu, 6-12 parts of Huajiaoshi, 15-25 parts of Chixinejin and 12-18 parts of Mutuoheimo.

[0012] Preferably, the composition comprises the following components in mass fraction:

[0013] 15 parts of Baizhu, 15 parts of Piaojiang, 30 parts of Dangshen, 10 parts of Wuzhuyu, 10 parts of Huajiaoshi, 20 parts of Chixinejin and 15 parts of Mutuoheimo.

[0014] The present application also provides an application of the traditional Chinese medicine composition for treating gastrointestinal polyp in a medicine for treating gastrointestinal polyp or a medicine for treating adverse reactions after gastrointestinal polyp resection.

[0015] Preferably, the dosage form of the medicine is: decoction, granules and pills.

[0016] Preferably, the preparation method of the decoction is as follows:

[0017] A. The traditional Chinese medicine composition in any one of claims 1-3 is placed in water and soaked for 0.25-1 h, and then the traditional Chinese medicine composition and the soaking liquid are separated;

[0018] B. The raw antigorite is first decocted for 0.25-1h with the soaking liquid, and then the other Chinese medicinal materials are added for decoction, and filtration is performed to obtain the oral medicinal liquid.

[0019] Preferably, the decoction is first boiled with strong fire, and then boiled for 0.25-1h with weak fire;

[0020] The application further provides a granule of the Chinese medicinal composition for gastrointestinal polyps, and the preparation method of the granule is characterized by comprising the following steps:

[0021] a. The Chinese medicinal composition is soaked in water for 0.25-1h;

[0022] b. The soaked medicinal materials are dried and then stir-fried, the stir-frying time is 20-40min, and the temperature is 30-50℃;

[0023] c. The stir-fried medicinal materials are taken out, crushed, sieved, mixed, stirred and then granulated to obtain the granule.

[0024] The application further provides a pill of the Chinese medicinal composition for gastrointestinal polyps, and the preparation method of the pill is characterized by comprising the following steps:

[0025] a'. The Chinese medicinal composition according to any one of claims 1-3 is soaked in water for 0.25-1h, and then the Chinese medicinal composition and the soaking liquid are separated;

[0026] b'. The soaked antigorite is dried at 50-80℃ under reduced pressure, and then crushed into fine powder for use;

[0027] c'. The other soaked medicinal materials are decocted with the soaking liquid for 0.25-1h, the decoction liquid is filtered, the filtrates are combined, and then concentrated into thick paste with a relative density of 1.30-1.40g / ml (60-70℃);

[0028] d'. The obtained thick paste is dried at 50-80℃ under reduced pressure, and then crushed into fine powder, mixed with the fine powder of the antigorite, stirred, and then water is added for granulation, dried, polished, and then the pill is obtained.

[0029] Compared with the prior art, the application has the following beneficial effects:

[0030] The traditional Chinese medicine composition provided by this invention warms the middle jiao and strengthens the spleen, dries dampness and resolves phlegm, removes blood stasis and stops bleeding, and eliminates masses and nodules. Modern pharmacology shows that Atractylodes macrocephala and Codonopsis pilosula can regulate gastrointestinal function and enhance the body's immunity; Zingiber officinale, Evodia rutaecarpa, Zanthoxylum bungeanum, and Myristica fragrans have anti-inflammatory, anti-tumor, and analgesic effects; Gynostemma pentaphyllum dissolves nodules and stops bleeding, shortening clotting and bleeding time; and Gizzard membrane of chicken can promote gastric motility. In summary, this composition has strong anti-inflammatory, analgesic, hemostatic, gastric motility-promoting, and immunity-enhancing effects. It can effectively reduce the number and diameter of gastrointestinal polyps, improve symptoms such as abdominal pain, diarrhea, borborygmus, poor appetite, and fatigue after polyp removal, and reduce the recurrence rate of gastrointestinal polyps. This formula is based on the understanding that gastrointestinal polyps are often a mixture of cold-dampness-phlegm-blood stasis-deficiency, and is based on the holistic concept of traditional Chinese medicine. The treatment focuses on the stomach and intestines, with the spleen as the root, and incorporates the kidneys and other organs for treatment, using the methods of transportation, elimination, and tonification. This treatment addresses both the symptoms and the root cause, harmonizes Qi and blood, and combines elimination with tonification, eliminating without harming and tonifying without causing stagnation. It disperses nodules, eliminates pathogenic factors, and strengthens the body's resistance. The core principle lies in removing accumulated pathogenic factors in the lower and middle Jiao, regulating the ascending and descending functions of the spleen and stomach, nourishing the source of Qi and body fluid production, and restoring the proper distribution of Qi and body fluids. The entire formula works synergistically to strengthen the spleen, replenish Qi, aid digestion, warm and dispel dampness, and disperse nodules, without harming the body's vital energy. This restores the balance of Yin and Yang, Qi and blood among the internal organs, thereby improving the symptoms of gastrointestinal polyps and preventing recurrence.

[0031] Compared with existing prescriptions, this prescription not only directly targets the gastrointestinal tract to eliminate pathogens, but also emphasizes early treatment of existing diseases, addressing the root cause of the disease, and comprehensively regulating multiple organs; it also emphasizes prevention before disease occurs, nourishing the spleen and stomach to ensure the body's vital energy is preserved, preventing the invasion of pathogens. Attached Figure Description

[0032] Figure 1 A statistical chart showing the treatment efficacy for intestinal polyps;

[0033] Figure 2 Diagnostic chart for gastric polyps;

[0034] Figure 3 The treatment effect is confirmed by colonoscopy. "+" indicates mild, "++" indicates severe, and "-" indicates none.

[0035] Figure 4 The treatment effect is confirmed by gastroscopy. "+" indicates mild, "++" indicates severe, and "-" indicates none. Detailed Implementation

[0036] This invention provides a traditional Chinese medicine composition for treating gastrointestinal polyps, comprising the following components in parts by weight:

[0037] 10-20 parts of Atractylodes macrocephala, preferably 12-18 parts, and more preferably 15 parts;

[0038] 10-30 parts of dried ginger, preferably 12-18 parts, and more preferably 15 parts;

[0039] Radix Codonopsis 15-40 parts, preferably 20-35 parts, and further preferably 30 parts;

[0040] Evodia 5-15 parts, preferably 6-12 parts, and further preferably 10 parts;

[0041] Zanthoxylum 5-15 parts, preferably 6-12 parts, and further preferably 10 parts;

[0042] Raw tourmaline 10-30 parts, preferably 15-25 parts, and further preferably 20 parts;

[0043] Fried Gigeriae 15-40 parts, preferably 20-35 parts, and further preferably 30 parts;

[0044] Bruised Myristica 10-20 parts, preferably 12-18 parts, and further preferably 15 parts;

[0045] In the present application, the used Atractylodes promotes the spleen and removes dampness, supplements the spleen and the kidney, removes dampness, and prevents the generation of phlegm; Radix Codonopsis supplements the spleen and the kidney, and restores the body's vital energy; the processed ginger assists the spleen and the kidney, and disperses the cold in the abdomen; Evodia warms the spleen and the stomach, and disperses the cold of the liver and the spleen; Zanthoxylum rises to the lung, and prevents the retention of pathogens, and reaches the intestines and the bowels, and supplements the spleen and the stomach, and disperses the cold, and is combined with Atractylodes and the processed ginger to dry the spleen and the kidney, and reaches the lower Dantian, and is combined with Evodia and the processed ginger to supplement the spleen and the kidney; Myristica warms the middle and the kidney, and disperses the cold to assist the spleen and the stomach, and is combined with Evodia to warm the spleen and the kidney, and enters the large intestine to directly reach the disease and assist the intestines to stop diarrhea. The use of tourmaline is divided into forging and raw, and the present application uses the raw tourmaline, i.e. raw tourmaline. The tourmaline disperses the blood stasis without damaging the normal, and stops the bleeding without retaining the pathogens, and disperses the blood stasis and the turbid qi to treat the diseases caused by the blood stasis and the turbid qi. Fried Gigeriae supplements the spleen and disperses the food, and is combined with Atractylodes and Myristica to supplement the spleen and the stomach, and the soft and strong accumulation and the accumulation of the blood stasis are dispersed.

[0046] The present application also provides the application of the traditional Chinese medicine composition in treating gastrointestinal polyps or treating the adverse reactions after the gastrointestinal polyp resection.

[0047] In the present application, the dosage form of the medicine is a decoction or a granule.

[0048] The present application also provides a decoction of the traditional Chinese medicine composition for treating gastrointestinal polyps, and the preparation method of the decoction is as follows:

[0049] A. The traditional Chinese medicine composition is soaked in water for 0.25-1 h, and then the traditional Chinese medicine composition and the soaking liquid are separated;

[0050] B. The raw tourmaline is first decocted in the soaking liquid for 0.25-1 h, and then the remaining traditional Chinese medicine is added for decoction, and then filtered to obtain the oral liquid.

[0051] In the present application, the decocting is first boiling with strong fire, and then boiling for 0.25-1h with weak fire.

[0052] In the present application, the strong fire refers to large and quick fire, and the use of which is to make the effective components of the medicine dissolve in large amount; in the present application, the mass fraction of the water for soaking is preferably 1000-2000 parts, further preferably 1200-1800 parts, and more further preferably 1600 parts; the soaking time is preferably 0.25-1h, further preferably 0.4-0.8h, and more further preferably 0.5h; the decocting time of the raw bavenite is preferably 0.25-1h, further preferably 0.4-0.8h, and more further preferably 0.5h; the decocting time with weak fire is preferably 0.25-1h, further preferably 0.4-0.8h, and more further preferably 0.5h; and the mass fraction of the obtained decoction is preferably 300-500 parts, further preferably 350-450 parts, and more further preferably 400 parts.

[0053] The present application also provides a granular powder of the traditional Chinese medicine composition for gastrointestinal polyps, and the preparation method of the granular powder is as follows:

[0054] a. soaking the traditional Chinese medicine composition in water for 0.25-1h;

[0055] b. drying and frying the soaked medicinal materials respectively, the frying time is 20-40min, and the temperature is 30-50℃;

[0056] c. grinding and sieving the slowly fried medicinal materials respectively, then mixing, stirring uniformly, and preparing into a granular powder.

[0057] The mass fraction of the water for soaking is preferably 1000-2000 parts, further preferably 1200-1800 parts, and more further preferably 1600 parts; the soaking time is preferably 0.25-1h, further preferably 0.4-0.8h, and more further preferably 0.5h; in the present application, the frying method is slow frying until the medicinal smell is slightly emitted, the frying time is preferably 20-40min, further preferably 25-35min, and more further preferably 30min, and the frying temperature is preferably 30-50℃, further preferably 35-45℃, and more further preferably 40℃; the slowly fried medicinal materials are ground and sieved, then mixed, stirred uniformly, and prepared into a granular powder, the sieving mesh number is preferably 100-200 meshes, further preferably 110-160 meshes, and more further preferably 120 meshes.

[0058] The present application also provides a pill of the traditional Chinese medicine composition for gastrointestinal polyps, and the preparation method of the pill is as follows:

[0059] a'. Soak the traditional Chinese medicine composition according to any one of claims 1 to 3 in water for 0.25 to 1 hour, and then separate the traditional Chinese medicine composition and the soaking solution;

[0060] b'. After soaking, the stamen stone is dried under reduced pressure at 50℃-80℃ and then pulverized into a fine powder for later use;

[0061] c'. Boil the other soaked medicinal materials in the soaking solution for 0.25 to 1 hour, filter the decoction, combine the filtrates, and concentrate to a thick paste with a relative density of 1.30 to 1.40 g / ml (60℃-70℃);

[0062] d'. The obtained thick paste is dried under reduced pressure at 50℃-80℃, pulverized into fine powder, mixed with fine powder of stamen stone, stirred evenly, made into pills with water, dried, and polished to obtain pills.

[0063] In this invention, the preferred mass fraction of the soaking water is 1000-2000 parts, more preferably 1200-1800 parts, and even more preferably 1600 parts; the preferred soaking time is 0.25-1 h, more preferably 0.4-0.8 h, and even more preferably 0.5 h; the preferred vacuum drying temperature is 40℃-100℃, more preferably 50℃-80℃, and even more preferably 65℃; the preferred simmering time is 0.25-1 h, more preferably 0.4-0.8 h, and even more preferably 0.5 h; the preferred concentration to a relative density is 1.20-1.50 g / ml (50℃-80℃), more preferably 1.30-1.40 g / ml (60℃-70℃), and even more preferably 1.35 g / ml (65℃); the preferred sieve mesh size is 100-200 mesh, more preferably 110-160 mesh, and even more preferably 120 mesh. This invention produces concentrated pills using traditional decoction, concentration, and drying processes. This not only preserves the original formula's efficacy characteristics, improves the drug's therapeutic effect and quality control, but also alters the drug's properties. These pills are characterized by small size, stable efficacy, no need for decoction, good taste, and convenient storage and carrying, making them suitable for long-term use and treatment, and facilitating clinical application and promotion.

[0064] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0065] Example 1

[0066] A traditional Chinese medicine composition for treating gastrointestinal polyps, comprising the following ingredients by weight: 15g Atractylodes macrocephala, 15g prepared ginger, 30g Codonopsis pilosula, 10g Evodia rutaecarpa, 10g Zanthoxylum bungeanum, 20g raw gypsum, 30g stir-fried chicken gizzard lining, and 15g braised nutmeg.

[0067] A medicine prepared from the above-mentioned traditional Chinese medicine composition for treating gastrointestinal polyps, the preparation method of the medicine is specifically as follows: first, the traditional Chinese medicine composition for treating gastrointestinal polyps is weighed according to the above-mentioned mass fraction and soaked in 1600 ml of pure water for 0.5 hours; the soaking liquid is used to decoct the baryte first for 0.5 hours, and then the remaining traditional Chinese medicine composition for treating gastrointestinal polyps is added for decocting; first, boil with a strong fire, then boil with a weak fire for 1 hour, and then filter with a 100-mesh filter screen to obtain 400 ml of oral liquid medicine. One dose per day, taken twice a day.

[0068] Example 2

[0069] A traditional Chinese medicine composition for treating gastrointestinal polyps, the raw materials of the traditional Chinese medicine composition are as follows according to weight fraction: Bai Zhi 15 g, Pao Jiang 15 g, Dang Shen 30 g, Wu Zhu Yu 10 g, Huo Jiao 10 g, Sheng Hua Rui Shi 20 g, Chao Ji Nei Jin 30 g, and Mu He Rou Dou 15 g.

[0070] A medicine prepared from the above-mentioned traditional Chinese medicine composition for treating gastrointestinal polyps, the preparation method of the medicine is specifically as follows: first, the traditional Chinese medicine composition for treating gastrointestinal polyps is weighed according to the above-mentioned mass fraction and soaked in 1600 ml of pure water for 0.5 hours; the soaking liquid is used to decoct the baryte first for 0.5 hours, and then the remaining traditional Chinese medicine composition for treating gastrointestinal polyps is added for decocting; first, boil with a strong fire, then boil with a weak fire for 1 hour, and then filter with a 100-mesh filter screen to obtain 400 ml of oral liquid medicine. One dose per day, taken twice a day.

[0071] Example 3

[0072] A traditional Chinese medicine composition for treating gastrointestinal polyps, the raw materials of the traditional Chinese medicine composition are as follows according to weight fraction: Bai Zhi 15 g, Pao Jiang 15 g, Dang Shen 30 g, Wu Zhu Yu 10 g, Huo Jiao 10 g, Sheng Hua Rui Shi 20 g, Chao Ji Nei Jin 30 g, and Mu He Rou Dou 15 g.

[0073] A medicine prepared from the above-mentioned traditional Chinese medicine composition for treating gastrointestinal polyps, the preparation method of the medicine is specifically as follows: first, the traditional Chinese medicine composition for treating gastrointestinal polyps is weighed according to the above-mentioned mass fraction and soaked in 1600 ml of pure water for 0.5 hours; the soaking liquid is used to decoct the baryte first for 0.5 hours, and then the remaining traditional Chinese medicine composition for treating gastrointestinal polyps is added for decocting; first, boil with a strong fire, then boil with a weak fire for 1 hour, and then filter with a 100-mesh filter screen to obtain 400 ml of oral liquid medicine. One dose per day, taken twice a day.

[0074] Example 4

[0075] A traditional Chinese medicine composition for treating gastrointestinal polyps, which comprises the following ingredients: Bai Zhi 15g, Pao Jiang 15g, Dang Shen 30g, Wu Zhu Yu 10g, Huo Jiao 10g, Sheng Hua Rui Shi 20g, Chao Ji Nei Jin 30g, and Tu He Rou Dou 15g.

[0076] The preparation method of the traditional Chinese medicine composition for treating gastrointestinal polyps comprises the following steps: after the prescription medicine is washed with clean water and sliced, the traditional Chinese medicine composition for treating gastrointestinal polyps is first taken according to the above mass fraction and soaked in 1500ml of pure water for 0.8 hours; the soaked medicinal materials are dried, then slowly fried until the medicinal smell is slightly emitted, the slow frying time is 30 minutes, and the temperature is 40℃; the slowly fried medicinal materials are taken out, crushed, and sieved, the sieving mesh number is 100 meshes, and the medicine is mixed, stirred uniformly, and then granulated into a granular powder, each bag contains 2.5g of the medicine. The granular powder is taken 2 bags each time, and is taken with boiling water in the morning and evening, which can be taken before or after meals.

[0077] Example 5

[0078] A traditional Chinese medicine composition for treating gastrointestinal polyps, which comprises the following ingredients: Bai Zhi 15g, Pao Jiang 15g, Dang Shen 30g, Wu Zhu Yu 10g, Huo Jiao 10g, Sheng Hua Rui Shi 20g, Chao Ji Nei Jin 30g, and Tu He Rou Dou 15g.

[0079] The preparation method of the traditional Chinese medicine composition for treating gastrointestinal polyps comprises the following steps: after the prescription medicine is washed with clean water and sliced, the traditional Chinese medicine composition for treating gastrointestinal polyps is first taken according to the above mass fraction and soaked in 2000ml of pure water for 0.5 hours; the soaked medicinal materials are dried, then slowly fried until the medicinal smell is slightly emitted, the slow frying time is 25 minutes, and the temperature is 42℃; the slowly fried medicinal materials are taken out, crushed, and sieved, the sieving mesh number is 130 meshes, and the medicine is mixed, stirred uniformly, and then granulated into a granular powder, each bag contains 2.5g of the medicine. The granular powder is taken 2 bags each time, and is taken with boiling water in the morning and evening, which can be taken before or after meals.

[0080] Example 6

[0081] A traditional Chinese medicine composition for treating gastrointestinal polyps, which comprises the following ingredients: Bai Zhi 15g, Pao Jiang 15g, Dang Shen 30g, Wu Zhu Yu 10g, Huo Jiao 10g, Sheng Hua Rui Shi 20g, Chao Ji Nei Jin 30g, and Tu He Rou Dou 15g.

[0082] The preparation method of the Chinese medicine composition for treating gastrointestinal polyps comprises the following steps: after the prescription medicine is washed with clean water and sliced, the Chinese medicine composition for treating gastrointestinal polyps is first taken according to the mass fraction and soaked in 1800ml of pure water for 0.5 hours; the soaked medicinal materials are dried, then slowly fried until the medicinal smell is slightly emitted, the slow frying time is 40 minutes, and the temperature is 45℃; the slowly fried medicinal materials are taken out, crushed, and sieved, the sieving mesh number is 120 meshes, and the medicine is mixed, stirred uniformly, and prepared into granular powder, and each bag contains 2.5g of medicinal ingredients. The granular powder is taken 2 bags each time, and is taken with boiling water in the morning and evening, and can be taken before or after meals.

[0083] Example 7

[0084] A Chinese medicine composition for treating gastrointestinal polyps, raw materials of the Chinese medicine composition are as follows: Baizhu 15g, Piaojiang 15g, Dangshen 30g, Wuzhuyu 10g, Huajiao 10g, Shenghuaruisheng 20g, Chaojineijin 30g, and Mutoheishu 15g.

[0085] The preparation method of the Chinese medicine composition for treating gastrointestinal polyps comprises the following steps: first, the Chinese medicine composition for treating gastrointestinal polyps is taken according to the mass fraction and soaked in 1200ml of pure water for 0.6 hours, and then the Chinese medicine composition and the soaking liquid are separated; the soaked huaruisheng is dried at 50℃ under reduced pressure, crushed into fine powder, sieved, the sieving mesh number is 100 meshes, and reserved; the other soaked medicinal materials are decocted with the soaking liquid for 0.6 hours, the decoction is filtered, the filtrate is combined, concentrated to a thick paste with a relative density of 1.25g / ml (60℃), and dried at 50℃ under reduced pressure, crushed, sieved, the sieving mesh number is 100 meshes, and uniformly mixed with the huaruisheng fine powder, stirred, water is added to granulate, dried, polished, and then the pill is obtained.

[0086] 5g (20 pills, 0.25g / pill) at a time, 2 times / d, taken with warm boiled water, and can be taken before or after meals.

[0087] Example 8

[0088] A Chinese medicine composition for treating gastrointestinal polyps, raw materials of the Chinese medicine composition are as follows: Baizhu 15g, Piaojiang 15g, Dangshen 30g, Wuzhuyu 10g, Huajiao 10g, Shenghuaruisheng 20g, Chaojineijin 30g, and Mutoheishu 15g.

[0089] The preparation method of the traditional Chinese medicine composition for treating gastrointestinal polyps comprises the following steps: first, the traditional Chinese medicine composition for treating gastrointestinal polyps is weighed according to the above-mentioned mass fraction and soaked in 1000 ml of purified water for 0.5 hours, and then the traditional Chinese medicine composition and the soaking liquid are separated; the soaked baryte is dried at 80 DEG C under reduced pressure, crushed into fine powder, sieved, the sieving mesh number is 120 meshes, and reserved; the other soaked medicinal materials are decocted with the soaking liquid for 0.25-1 hours, the decoction is filtered, the filtrates are combined, concentrated to a thick paste with a relative density of 1.40 g / ml (65 DEG C), and dried at 80 DEG C under reduced pressure, crushed, sieved, the sieving mesh number is 120 meshes, and uniformly mixed with the baryte fine powder, stirred, water is added to granulate, dried, polished, and then the pill is obtained.

[0090] Example 9

[0091] A traditional Chinese medicine composition for treating gastrointestinal polyps, raw materials of the traditional Chinese medicine composition are as follows: Baizhu 15g, Piaojiang 15g, Dangshen 30g, Wuzhuyu 10g, Huajiao 10g, Shenghuabaidish 20g, Chaojinnanjing 30g, and Mutuoqie 15g.

[0092] The preparation method of the traditional Chinese medicine composition for treating gastrointestinal polyps comprises the following steps: first, the traditional Chinese medicine composition for treating gastrointestinal polyps is weighed according to the above-mentioned mass fraction and soaked in 1300 ml of purified water for 0.7 hours, and then the traditional Chinese medicine composition and the soaking liquid are separated; the soaked baryte is dried at 70 DEG C under reduced pressure, crushed into fine powder, sieved, the sieving mesh number is 130 meshes, and reserved; the other soaked medicinal materials are decocted with the soaking liquid for 0.7 hours, the decoction is filtered, the filtrates are combined, concentrated to a thick paste with a relative density of 1.45 g / ml (70 DEG C), and dried at 70 DEG C under reduced pressure, crushed, sieved, the sieving mesh number is 130 meshes, and uniformly mixed with the baryte fine powder, stirred, water is added to granulate, dried, polished, and then the pill is obtained.

[0093] Example 10

[0094] In order to verify the actual curative effect of the present application, the following case is described in detail.

[0095] Case 1

[0096] Luo, female, 49 years old.

[0097] Complaint: Difficulty in defecation for 1 year.

[0098] Initial diagnosis: 2022-7-24.

[0099] Present illness: The patient had difficulty defecating for 1 year, felt weak in defecation, prolonged defecation time, loose stool with mucus, 1-2 times a day, accompanied by abdominal cold pain, anal heaviness. Once in the external hospital, no obvious positive signs in the abdomen, abdominal color Doppler ultrasound excluded abdominal solid organ lesions. Colonoscopy showed multiple intestinal polyps. Pathology showed rectal tubular-villous adenoma, moderate to severe dysplasia in part of the gland. Within a year, polypectomy has been performed under endoscopy for 4 times, and 100 doses of Chinese medicine have been taken. After treatment, the above symptoms did not improve significantly, and the polyps still grew repeatedly. Now: defecation is not smooth, accompanied by abdominal cold pain, anal heaviness, loose stool with mucus, 1 time a day. Stomach distension, belching, hunger and bloating are aggravated, fatigue, mental fatigue, usually eat cold, think heavy, eat less and poor appetite. Purple tongue, white and greasy fur, thin and slippery pulse.

[0100] Prescription: Baizhu 20g, Paojiang 30g, Dangshen 30g, Wuzhuyu 9g, Huajiao 6g, Shenghuaruisheng 30g, Chixinejin 20g, Mugeleshurou 15g. 7 doses. Take 1 dose a day, 2 times in the morning and evening.

[0101] Second visit: August 2, 2022, after taking medicine, abdominal pain is relieved, stool is gradually formed, mucus is rarely seen. Dark tongue, thin white fur, thin and wiry pulse.

[0102] Prescription: Baizhu 20g, Paojiang 15g, Dangshen 15g, Wuzhuyu 6g, Huajiao 6g, Shenghuaruisheng 25g, Chixinejin 30g, Mugeleshurou 10g.

[0103] Third visit: October 31, 2022, the patient did not change the original prescription, took medicine once a month, and the symptoms were further improved after continuous medication for nearly three months. The abdomen was not painful, the stool was formed, there was no mucus. Fatigue and mental fatigue improved, food intake was normal, tongue was pale, thin white fur, and thin and wiry pulse.

[0104] January 8, 2023, colonoscopy: chronic rectitis, no intestinal polyps were found; pathological examination showed no dysplasia.

[0105] Fourth visit: April 2, 2023, since taking medicine, there has been no obvious discomfort in the abdomen, the stool is formed, and there is no anal heaviness. On July 2, 2023, colonoscopy showed: chronic colitis, no intestinal polyps were found.

[0106] Based on the above prescription, the prescription was added and subtracted according to the symptoms for more than a year. On January 2024, colonoscopy showed no intestinal polypoid adenoma or atypical hyperplasia, and the disease was stable.

[0107] Case 2

[0108] Zhu, male, 42 years old.

[0109] Chief complaint: recurrent abdominal pain and diarrhea for half a year.

[0110] Initial diagnosis: October 12, 2022.

[0111] Present illness: The patient had diarrhea and left lower abdominal pain after improper diet half a year ago. The patient took western medicine (details unknown) on his own, but the symptoms did not improve significantly. Current symptoms: Diarrhea in the morning, accompanied by abdominal pain, 2-3 times a day, with loose stools mixed with mucus. The patient is thin, weak, has poor appetite, and sleeps poorly. Night urination is more. The tongue is pale, with thin white fur, and the pulse is weak and weak.

[0112] Auxiliary examination: Colonoscopy showed multiple colonic polyps, about 5-10 mm in diameter. Pathology showed mixed type of adenomatous polyps and hyperplastic polyps.

[0113] Prescription: Baizhu 20g, Paojiang 18g, Dangshen 30g, Wuzhuyu 10g, Huajiao 6g, Shenghuaruisheng 20g, Chaji Neijin 25g, Mutohe Roudoukou 20g. 7 doses. Decoction 400ml, 1 dose a day, 2 times a day.

[0114] Second visit: October 20, 2022, left lower abdominal pain relieved, stool not smooth improved, mucus reduced, 1 time a day, morning diarrhea eased, the rest is the same as before. Tongue pale, tongue fur thin white, pulse weak. Based on the above prescription, add and subtract 6 months of medication according to symptoms.

[0115] Third visit: April 29, 2023, diet and bowel movements are normal, cold and fatigue are improved, weight increased by 5kg. Recheck colonoscopy, polyps reduced by 2 / 3, maximum polyp diameter <5mm.

[0116] Follow-up to date, the condition is stable.

[0117] Case 3

[0118] Tang, male, 48 years old.

[0119] Complaint: Recurrent abdominal pain and diarrhea for half a year.

[0120] Initial diagnosis: April 13, 2023.

[0121] Present illness: The patient had stomach pain two years ago, which worsened after fasting and eating. The patient had poor appetite. The patient had been to the local hospital for treatment, and the gastroscopy showed that the mucosa of the greater curvature of the gastric antrum was about 0.4cm x 0.25cm, smooth and congested, with red and white around. Diagnosis of chronic atrophic gastritis, localized polyp hyperplasia. After treatment with western medicine (details unknown), the symptoms did not improve significantly. Current symptoms: paroxysmal stomach pain, aggravated after fasting and eating, morning mouth bitter, nausea, thin, weak limbs, poor appetite, sleep well, small urination, thin stool, 1-2 times a day. Tongue purple, white and greasy fur, pulse string thin and smooth.

[0122] Prescription: Baizhu 20g, Paojiang 15g, Dangshen 30g, Wuzhuyu 10g, Huajiao 6g, Shenghuaruisheng 30g, Chaxi Neijing 25g, Muxie Roudoukou 18g. 7 doses. Decoction 400mL, 1 dose per day, 2 times a day.

[0123] Second visit: After taking the above prescription for more than 1 month, the patient still feels sticky in the mouth, nausea, and loose stools. Spleen deficiency and dampness still exist. Continue taking the prescription.

[0124] Third visit: After taking the above prescription for more than 2 months, the patient's symptoms have improved significantly. Gastroscopy: no gastric polyps, diagnosed as atrophic gastritis. To consolidate the effect, the patient continues to take the medicine for half a year.

[0125] Example 11

[0126] Clinical data

[0127] From 2021 to 2023, 30 patients with intestinal polyps were treated with the self-made Huaruisheng Decoction. The prescription uses Baizhu 15g, Paojiang 15g, Dangshen 30g, Wuzhuyu 10g, Huajiao 10g, Shenghuaruisheng 20g, Chaxi Neijing 30g, and Muxie Roudoukou 15g. One dose per day, decoction, 2 times a day. The clinical efficacy observation results show that 18 cases were cured (clinical symptoms disappeared, intestinal mirror results suggested that polyps disappeared), 11 cases were effective (clinical symptoms basically disappeared, intestinal mirror showed that the number of polyps decreased, and the diameter of polyps decreased), and 1 case was ineffective (symptoms were slightly relieved, but the size of polyps did not change significantly), the total effective rate was 97%. Clinical observation showed that this prescription had no adverse reactions.

[0128] Table 1. Efficacy statistics of Huaruisheng Decoction in the treatment of intestinal polyps

[0129] n Healing Effective Ineffective Total effective rate 30 18(60％) 11(37％) 1(3％) 29(97％)

[0130] From 2021 to 2023, 20 patients with gastric polyps were treated with the self-made Huaruisheng Decoction. The prescription uses Baizhu 15g, Paojiang 15g, Dangshen 30g, Wuzhuyu 10g, Huajiao 10g, Shenghuaruisheng 20g, Chaxi Neijing 30g, and Muxie Roudoukou 15g. One dose per day, decoction, 2 times a day. The clinical efficacy observation results show that 15 cases were cured (clinical symptoms disappeared, gastroscopy results suggested that polyps disappeared), 4 cases were effective (clinical symptoms basically disappeared, gastroscopy showed that the number of polyps decreased, and the diameter of polyps decreased), and 1 case was ineffective (symptoms were slightly relieved, but the size of polyps did not change significantly), the total effective rate was 95%. Clinical observation showed that this prescription had no adverse reactions.

[0131] Table 2. Efficacy statistics of Huaruisheng Decoction in the treatment of gastric polyps

[0132] n Healing Effective Ineffective Total effective rate 20 15(75％) 4(20％) 1(5％) 19(95％)

[0133] In summary of the above cases, the traditional Chinese medicine composition has good curative effect, has remarkable effect on improving symptoms such as nausea, vomiting, belching, abdominal distension, abdominal pain, and loss of appetite of patients with gastrointestinal polyps, reduces recurrence after cure, and greatly reduces the mental and economic burden of patients.

[0134] The above only describes the preferred embodiments of the present application, and it should be noted that those skilled in the art can make several improvements and refinements without departing from the principles of the present application, and these improvements and refinements should also be considered within the protection scope of the present application.

Claims

1. A traditional Chinese medicine composition for treating gastrointestinal polyps, characterized in that, It is composed of the following components in mass fraction: Atractylodes 10~20 parts, Cannon ginger 10~30 parts, Codonopsis 15~40 parts, Evodia 5~15 parts, Zanthoxylum 5~15 parts, raw fluorite 10~30 parts, fried chicken inner gold 15~40 parts, bran baked nutmeg 10~20 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, It is composed of the following components in mass fraction: Atractylodes 12~18 parts, Cannon ginger 12~18 parts, Codonopsis 20~35 parts, Evodia 6~12 parts, Zanthoxylum 6~12 parts, raw fluorite 15~25 parts, fried chicken inner gold 20~35 parts, bran baked nutmeg 12~18 parts.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, It is composed of the following components in mass fraction: Atractylodes 15 parts, Cannon ginger 15 parts, Codonopsis 30 parts, Evodia 10 parts, Zanthoxylum 10 parts, raw fluorite 20 parts, fried chicken inner gold 30 parts, bran baked nutmeg 15 parts.

4. The use of the traditional Chinese medicine composition of any one of claims 1-3 in the preparation of a medicament for treating gastrointestinal polyps or treating the clinical symptoms of gastrointestinal polyps and preventing the recurrence of gastrointestinal polyps.

5. Use according to claim 4, characterized in that, The dosage form of the medicament is: decoction, granules or pills.

6. A decoction of a traditional Chinese medicine composition for treating gastrointestinal polyps, characterized in that, The preparation method of the decoction is as follows: A. The traditional Chinese medicine composition of any one of claims 1-3 is soaked in water for 0.25-1 h, and the traditional Chinese medicine composition and the soaking liquid are separated; B. The raw fluorite is decocted for 0.25-1 h with the soaking liquid, and then the remaining traditional Chinese medicines are added for decoction. After filtration, an oral liquid is obtained.

7. The tea of claim 6, wherein, The decoction is first boiled with a strong fire, and then boiled with a weak fire for 0.25-1 h.

8. A granular powder of a traditional Chinese medicine composition for gastrointestinal polyps, characterized in that, The preparation method of the granules is as follows: a. The traditional Chinese medicine composition of any one of claims 1-3 is soaked in water for 0.25-1 h; b. The soaked medicinal materials are dried and then fried, with a frying time of 20-40 min and a temperature of 30-50℃; c. The slowly fried medicinal materials are taken out, crushed, sieved, then mixed and stirred uniformly to form granules.

9. A pill of a traditional Chinese medicine composition for gastrointestinal polyps, characterized in that, The preparation method of the pills is as follows: a'. The traditional Chinese medicine composition of any one of claims 1-3 is soaked in water for 0.25-1 h, and the traditional Chinese medicine composition and the soaking liquid are separated; b'. The soaked fluorite is dried at 50℃-80℃ under reduced pressure, crushed into fine powder, and used as needed; c'. The other soaked medicinal materials are decocted with the soaking liquid for 0.25-1 h. The decoction liquid is filtered, combined, and concentrated to a thick paste with a relative density of 1.30-1.40 g / ml at 60℃-70℃; d'. The obtained thick paste is dried at 50℃-80℃ under reduced pressure, crushed into fine powder, and mixed uniformly with the fluorite fine powder. After stirring, the mixture is granulated with water, dried, polished, and the pills are obtained.

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