A composition containing afidopyropen and cyantraniliprol

Abstract

The present application provides a kind of composition containing aforana and bromocyclen, wherein the weight ratio of aforana and bromocyclen is 1:100 to 100:1.The present application also relates to the use of the composition for controlling agricultural insects, which has a synergistic effect.

Description

TECHNICAL FIELD

[0001] The present application belongs to the field of agriculture, and particularly relates to a composition containing afoxolaner and cyantraniliprole and application thereof. BACKGROUND

[0002] Afoxolaner is an isoxazoline insecticide and acaricide, which acts on ligand-gated chloride channels, especially inhibits the neurotransmitter gamma-aminobutyric acid (GABA) gated channel, thereby blocking the transmission of chloride ions from the presynaptic membrane to the postsynaptic membrane, resulting in increased neuronal activity and overexcitation death of animals. Afoxolaner is first used in the field of veterinary medicine as an in vitro ectoparasiticide for dogs, which can kill both ticks and fleas, and has the characteristics of rapid onset, high safety and convenient oral administration. Then, it is found that afoxolaner can be used for preventing and treating agricultural pests.

[0003] Cyantraniliprole is the second generation of fish nitrile receptor inhibitor insecticide developed by Dupont Company after chlorantraniliprole. Cyantraniliprole is formed by changing various polar groups on the benzene ring, and has higher efficiency and wider application in crops, and can effectively control pests of Lepidoptera, Hemiptera and Coleoptera.

[0004] CN109068651A discloses a composition comprising an isoxazoline compound and at least one additional active agent, wherein the isoxazoline compound can be a compound of structure (Ia) (i.e. afoxolaner), and the additional active agent can be abamectin, etc., and the composition is used in the field of veterinary medicine.

[0005] There is no report on the combination of afoxolaner and cyantraniliprole in the prior art. SUMMARY

[0006] The present inventors have found that afoxolaner and cyantraniliprole have a synergistic effect in insect control. Based on this, the present application is completed.

[0007] The present application relates to a composition containing afoxolaner and cyantraniliprole, wherein the weight ratio of afoxolaner to cyantraniliprole is 1:100 to 100:1.

[0008] According to the composition of the present application, the weight ratio of afoxolaner to cyantraniliprole is preferably 1:50 to 100:1.

[0009] According to the composition of the present application, the composition further comprises an agriculturally acceptable adjuvant and / or carrier.

[0010] The composition according to the present application is characterized in that the pesticide composition is prepared into a suspension concentrate, an emulsion in water, a wettable powder, a water dispersible granule, an emulsifiable concentrate, a microemulsion.

[0011] The composition according to the present application is characterized in that the weight percentage of the active ingredient in the composition is 1-90%.

[0012] The composition according to the present application is used for controlling agricultural insects.

[0013] The use according to the present application is characterized in that the agricultural insects are preferably insects of the order Lepidoptera.

[0014] The method for controlling agricultural insects using the composition according to the present application is characterized in that the composition is contacted with the agricultural insects; or the composition is applied to the living environment of the agricultural insects. DETAILED DESCRIPTION

[0016] The present application provides a composition containing afidopyropen and brofenvalerate, wherein the weight ratio of afidopyropen to brofenvalerate in the composition is 1:100 to 100:1.

[0017] Preferably, the weight ratio of afidopyropen to brofenvalerate is 1:50 to 100:1, more preferably 1:25 to 75:1, for example 1:25, 1:20, 1:15, 1:10, 1:5, 1:1, 5:1, 10:1, 15:1, 20:1, 25:1, 50:1, 75:1, most preferably 10:1 to 50:1.

[0018] In an embodiment of the present application, the composition according to the present application further comprises an agriculturally acceptable adjuvant and / or carrier, and the pesticide composition is prepared into a suspension concentrate, an emulsion in water, a wettable powder, a water dispersible granule, an emulsifiable concentrate, a microemulsion. Preferably, it is prepared into a suspension concentrate, an emulsion in water, a water dispersible granule, and a wettable powder.

[0019] In the preparation, the total amount of the active ingredient is 1-90%, preferably 5-80%, more preferably 6-50%.

[0020] The agriculturally acceptable adjuvant and / or carrier includes, but is not limited to, a dispersant, a wetting agent, an emulsifier, a solvent, a thickening agent, an antifreezing agent, a binder, a disintegrant, an antifoaming agent, a carrier, etc. Among them,

[0021] The dispersing agent can be selected from one or more of a nonylphenol polyoxyethylene ether, a glycerol fatty acid polyoxyethylene ether, a polyoxyethylene alkyl aryl ether, a polyoxyethylene lanolin alcohol, an alkyl naphthalene sulfonate, a naphthalene sulfonate formaldehyde condensate, a naphthalene sulfonate formaldehyde condensate sodium salt, a lignin sulfonate, a sodium p-hydroxyphenyl lignin sulfonate, a fatty alcohol polyoxyethylene ether sulfate, an alkyl phenol polyoxyethylene ether formaldehyde condensate, a dodecyl trimethyl ammonium salt, an alkyl dimethyl benzyl ammonium salt, a p-methoxy fatty amido benzene sulfonic acid, a p-methoxy fatty amido benzene sulfonic acid salt, a fatty alcohol polyoxyethylene ether, a fatty alcohol polyoxyethylene ether phosphate, a polyoxyethylene sorbitan fatty acid ester.

[0022] The wetting agent can be selected from one or more of a sodium lauroyl sarcosinate, a sodium N-lauroyl glutamate, a dioctyl sulfosuccinate, a polyoxyethylene alkyl aryl ether phosphate ester salt, a trisiloxane polyoxyethylene ether, a sodium lauryl sulfate, a calcium dodecyl benzene sulfonate, a sodium isooctanol succinate sulfonate, a sodium oleyl methyl taurate, a triphenyl ethyl phenol polyoxyethylene ether, a castor oil polyoxyethylene ether, a polyoxyethylene fatty acid ester, a higher fatty acid glycerol ester, a sorbitan fatty acid ester, a fatty alcohol polyoxyethylene ether, an alkyl phenol polyoxyethylene ether phosphate ester.

[0023] The emulsifying agent can be selected from one or more of a lignin sulfonate, a naphthalene sulfonate formaldehyde condensate, a benzyl dimethyl phenol polyoxyethyl ether, a styryl phenyl polyoxyethylene ether, a phenyl ethyl phenol polyoxyethylene polypropylene ether, a castor oil polyoxyethylene ether nonylphenol polyoxyethylene ether, a fatty alcohol polyoxyethylene ether, a polyoxyethylene alkyl ether, an alkyl phenol formaldehyde resin polyoxyethylene ether, a polyoxyethylene sorbitol fatty acid ester, a sodium lauryl sulfate, a sodium dodecyl benzene sulfonate, a calcium dodecyl benzene sulfonate, a nonylphenol polyoxyethylene ether phosphate ester, a phenyl phenol polyoxyethyl ether phosphate ester, a styrene polyoxyethylene ether ammonium sulfate salt, a sorbitan monostearate, a sorbitan monostearate polyoxyethylene ether, a sorbitan fatty acid ester polyoxyethylene ether.

[0024] The solvent can be selected from one or more of acetone, dimethylformamide, dimethyl sulfoxide, xylene, chloroform, dichloromethane, ethyl acetate, cyclohexane, ethyl glycol ether, cyclohexanone, N-methyl pyrrolidone, coconut fatty acid methyl ester, cyclohexanol, methyl glycol ether, acetonitrile, paraffin, tetralin, isophorone, soybean oil, cottonseed oil, methyl esterified vegetable oil, dimethyl phthalate.

[0025] The thickening agent can be selected from one or more of gum arabic, carboxymethyl cellulose, sodium carboxymethyl cellulose, xanthan gum, gelatin, polyvinyl alcohol, magnesium aluminum silicate, sodium alginate.

[0026] The antifreezing agent can be selected from one or more of ethylene glycol, propylene glycol, glycerol, polyethylene glycol, sorbitol.

[0027] The adhesive may be selected from one or more of starch, dextrin, sucrose, carboxymethyl cellulose, carboxyethyl cellulose, gelatin, gum arabic, and xanthan gum.

[0028] The disintegrant may be selected from one or more of sodium sulfate, calcium sulfate, sodium bicarbonate, ammonium sulfate, magnesium chloride, sodium carboxymethyl starch, and urea.

[0029] The defoamer may be selected from one or more of silicone, butyl phosphate, isobutyl phosphate, and n-octanol.

[0030] The carrier may be selected from one or more of the following: diatomaceous earth, kaolin, bentonite, attapulgite, montmorillonite, calcium carbonate, zeolite, acid clay, water, castor oil, soybean oil, corn oil, turpentine, rapeseed oil, methyl oleate, coconut oil, and mineral oil.

[0031] Another aspect of the present invention relates to the use of the described composition for the control of agricultural insects. Wherein:

[0032] Applicable agricultural plants include:

[0033] Crops: rice, wheat, barley, sorghum, corn, cotton, soybeans, kidney beans, peanuts, buckwheat, sugar beets, rapeseed, sunflowers, sugarcane, tobacco, etc.

[0034] Vegetables: cucumber, eggplant, tomato, winter melon, potato, radish, mustard greens, turnip, Chinese cabbage, kale, broccoli, etc.

[0035] Fruit trees: apple, peach, cherry, apricot, citrus, lemon, blueberry, grape, banana, etc.

[0036] Agricultural insects that can be used for control include:

[0037] Lepidoptera: Diamondback moth ( Plutellaxylostella ),cabbage caterpillar( PierisrapaeLinnaeus Fall armyworm ( Spodopterafugiperda Grass armyworm () Spodopterafrugiperda ), Inchworm ( Rachiplusianu Soybean noctuid moth ( Pseudoplusiaincludens Rice stem borer ( Sesamiainferens ), rice leaf roller ( CnaphalocrocismedinalisGuenee ), stem borer ( Chilo suppressalis Tomato leafminer ( Tutaabsoluta ), Powdery Spotted Noctuid Moth ( Trichoplusiani ), Powder stem borer Sesamianonagrioides ), Powdered Noctuid moth ( Trichoplusiani ), cabbage moth ( Mamestrabrassicae citrus leafminer ( Phyllocnistiscitrella ), pear fruit moth ( Grapholithamolesta American armyworm ( PseudaletiaunipunctaHaworth ), cotton moth (EariasvittellaFabricius ), Adoxophyes spp. (leafrollers), Adoxophyesorana ), Anomis sabulifera (cutworm), PectinophoragossypiellaSaunders ), Biston betularia (peacock moth), HelicoverpaarmigeraHübner ), Brevicoryne brassicae (cabbage aphid), Heliothisarmigera ), Chilo spp. (stemborer), Scirpophagaincertulas ), Chrysodeixis spp. (looper), SpodopteraexiguaHübner ), Chrysopa spp. (green lacewing), Plutellaxylostella ), Chrysoperla spp. (green lacewing), Agrotisypsilon ), Cnaphalocrocis spp. (bollworm), Spodopteralitura ), Crambus spp. (bollworm), OstrinianubilalisHübner ).

[0038] Diptera: Aedes aegypti (mosquito), Aedesaegypti ), Agromyza orana (leafminer), Liriomyzabrassicae ), Anastrepha ludens (fruit fly), Phorbiaantiqua ), Anopheles spp. (mosquito), Ceratitiscapitata ), Bactrocera oleae (olive fruit fly), Deliaradicum ), Bactrocera oleivora (spotted alfalfa aphid), Bactroceracucurbitae ), Bactrocera oleivora (spotted alfalfa aphid), Psilarosae ), Bactrocera oleivora (spotted alfalfa aphid), MuscadomesticaLinnaeus ), Bactrocera oleivora (spotted alfalfa aphid), Bactroceradorsalis ), Bactrocera oleivora (spotted alfalfa aphid), Deliacoarctata ), Bactrocera oleivora (spotted alfalfa aphid), Sitodiplosismosellana ), Bactrocera oleivora (spotted alfalfa aphid), Mayetioladestructor ), Bactrocera oleivora (spotted alfalfa aphid), Culextarsalis ), Bactrocera oleivora (spotted alfalfa aphid), Liriomyzatrifolii ), Bactrocera oleivora (spotted alfalfa aphid), Melophagusovinus ), Bactrocera oleivora (spotted alfalfa aphid), Rhagoletispomonella ), Bactrocera oleivora (spotted alfalfa aphid), Rhagoletiscerasi ), Bactrocera oleivora (spotted alfalfa aphid), Dasineurabrassicae ), Bactrocera oleivora (spotted alfalfa aphid), Dacusoleae ), Bactrocera oleivora (spotted alfalfa aphid), Agromyzafrontella ).

[0039] Hemiptera: Aleurocanthus spinifer (whitefly), SogatellafurciferaHorvath ), Aleurothrixus floccosus (whitefly), Trialeurodesvaporariorum ), Aphis fabae (black bean aphid), AphisfabaeScopoli ), Aphis gossypii (spotted alfalfa aphid), Aphisforbesi ), Aulacophora cirrosa (asian beetle), Leptocorisaoratorius ), Aulacophora cirrosa (asian beetle), Aphisglycines ), Aulacophora cirrosa (asian beetle), Macrosiphumeuphorbiae ), Aulacophora cirrosa (asian beetle), Nilaparvatalugens ), Aulacophora cirrosa (asian beetle), NezaraviridulaLinnaeus ), Aulacophora cirrosa (asian beetle), Brevicorynebrassicae ), Aulacophora cirrosa (asian beetle), Bemisiatabaci ), Aulacophora cirrosa (asian beetle), Diaphorinacitri ), Aulacophora cirrosa (asian beetle), Parlatoriaziziphi ), Aulacophora cirrosa (asian beetle), Nephotettixnigropictus ), Aulacophora cirrosa (asian beetle), Ceroplastesrubens ), Aulacophora cirrosa (asian beetle), Aonidiellaaurantii ), Aulacophora cirrosa (asian beetle), Laodelphaxstriatellus), cowpea aphid ( AphiscraccivoraKoch ), Citrus bifida ( Toxopteraaurantiiand ), pear psylla ( Psyllapiri ), wheat aphid ( SitobionavenaeFabricius ), wheat aphid ( Schizaphisgraminum ), wheat double-tailed aphid ( Diuraphisnoxia ), wheat without web aphids ( Metopolophiumdirhodum ), cotton red bug ( Dysdercuscingulatus ), Cotton-red-bellied stink bug ( Leptoglossusphyllopus ), cotton aphids AphisgossypiiGlover Apple aphids Aphispomi ), apple psyllid ( Psyllamali ), grape phylloxera ( Viteusvitifolii ), grape phylloxera ( Phylloxeravitifoliae ), Peach aphid ( MyzuspersicaeSulzer Greenhouse whiteflies ( Trialeurodesvaporariorum ), small brown rice fly ( LaodelphaxstriatellusFallen ), whiteflies ( BemisiatabaciGennadius ), leafhopper ( Empoascaspp .), corn cicada ( PeregrinusmaidisAshmead ), corn aphids Rhopalosiphummaidis ), corn constrictor aphid ( RhopalosiphummaidisFitch ).

[0040] Thysanoptera: rice thrips ( Baliothrips biformis ), brown thrips ( Frankliniellafusca ), Western flower thrips ( Frankliniellaoccidentalis ), orange thrips ( Scirtothripscitri ), Tea yellow thrips ( Scirtothripsdorsalis ), Yellow-breasted thrips ( Thripshawaiiensis ), soybean thrips ( Thripsnigropilosus ), Eastern thrips ( Thripsorientalis );

[0041] Hymenoptera: Argentine ant ( Iridomyrmexhumilis ), black fire ants ( Solenopsisrichtery ), red imported fire ants Solenopsisinvicta ), red ants Pogonomyrmexbarbatus ),wasp( Polistesrubiginosa Yellow-edged wasp ( Vespacrabro ), hornet ( Dolichovespulamaculata ), genus *Hemiberlesia* ( Crematogaster Southern fire ants Solenopsisxyloni Leafcutter ants Attacephalotes ), tropical fire ants ( Solenopsisgeminata ), Velvet ants Dasymutillaoccidcntalis ), small black ants ( Monomoriumminimum Xinjiang cabbage leaf bee ( Athaliarosae ).

[0042] Coleoptera: Egyptian cloverleaf weevil ( Hyperabrunneipennis ), dark click beetle ( Agriotes obscurus), cabbage seedpod weevil (Conotrachelus nenuphar Ceutorhynchus assimilis ), bean weevil (Zabrus subfasciatus Acanthoscelides obtectus ), bean weevil (Zabrus subfasciatus Bruchus rufimanus ), strawberry root weevil (Hylobius transversovittatus Otiorrhynchus ovatus ), boll weevil (Anthonomus grandis Anthonomus grandis Boheman ), boll weevil (Anthonomus grandis Anthonomus grandis ), Mexican bean beetle (Epilachna varivestis Epilachna varivestis ), South American leaf beetle (Oreosema nubilum Diabrotica speciosa ), four spotted bean weevil (Acanthoscelides obtectus Callosobruchus maculatus ), pea weevil (Bruchus pisorum Bruchus pisorum ), corn rootworm (Diabrotica virgifera Diabrotica virgifera ), corn rootworm (Diabrotica virgifera Diabrotica virgif eravirgifera LeConte ), corn rootworm (Diabrotica virgifera Melanotus communis ), corn rootworm (Diabrotica virgifera Sitophilus zeamais ), bluegrass weevil (Hyperodes fasciatus Listronotus maculicollis Dietz ), alfalfa weevil (Hyperodes fasciatus Hypera postica ).

[0043] Orthoptera: East Asian migratory locust (Locusta migratoria Locusta migratoria ), African mole cricket (Gryllotalpa australis Gryllotalpa africana ), mole cricket (Gryllotalpa australis Scapteriscus vicinus Scudder ), desert locust (Schistocerca gregaria Schistocerca americana ), desert locust (Schistocerca gregaria Schistocerca americana Drury ), migratory black locust (Melanoplus sanguinipes Melanoplus sanguinipes ), migratory locust (Melanoplus sanguinipes Locusta migratoria Linnaeus ), migratory grasshopper (Melanoplus sanguinipes Melanoplus sanguinipes Fabricius , desert locust (Schistocerca gregaria Schistocerca gregaria Forskal ), stone locust (Melanoplus spretus Melanoplus pretus ), two striped grasshopper (Melanoplus bivittatus Melanoplus bivittatus ), striped red locust (Nomadacris septemfasciata Nomadacris septemfasciata ), brown locust (Locusta migratoria Locusta napardalina ).

[0044] In a preferred embodiment of the present application, the agricultural insect is selected from Lepidoptera, Hemiptera insects, preferably comprising the following: Chilo suppressalis ), diamondback moth (Plutella xylostella Plutella xylostella ), brown planthopper (Nilaparvata lugens Nilaparvata lugens ).

[0045] Another aspect of the present application relates to a method for controlling agricultural insects using the composition according to the present application, characterized in that the composition is contacted with the agricultural insect, or the composition is applied to the living environment of the agricultural insect. DETAILED DESCRIPTION

[0046] The present application will be further described with reference to the following examples, but the present application is not limited to them. In addition, the percentages described in the following examples are all percentages by weight, unless otherwise specified.

[0047] I. Joint toxicity test

[0048] Test object: Chilo suppressalis (Walker) Chilo suppressalis Healthy and uniform larvae were selected.

[0049] Test agents: Afidopyropen technical material, cyantraniliprole technical material; both were purchased from the market.

[0050] Test method: According to the Pesticide Indoor Biological Test Guidelines NY / T 1154.6-2006 Insecticide Part 6 “Insecticide Activity Test Immersion Method” and the Pesticide Indoor Biological Test Guidelines NY / T 1154.7-2006 Insecticide Part 7 “Combined Action of Mixtures”, the biological activity of single agents and mixed preparations with different proportions of the two on Chilo suppressalis was determined. Specifically:

[0051] According to the proportions set in Table 1 below, the treatment agents were dissolved in an appropriate amount of acetone, and then a series of concentrations (calculated based on the active ingredients of pesticides) were prepared with 1% Tween 80 aqueous solution. Then, the test insects were immersed in the solution for 10s, removed, and the excess pesticide solution on the insects was absorbed with filter paper, and then the insects were transferred to normal conditions for feeding. Each treatment was repeated 3 times, with 20 insects per repetition, and 1% Tween 80 aqueous solution treatment was used as a blank control. After 48h of treatment, the mortality of test insects was investigated, the corrected mortality was calculated, and the LC 50 of each treatment was calculated. Then, according to the method of Sun Yunpei, the co-toxicity coefficient CTC of each treatment was calculated to evaluate the synergistic effect. Wherein, CTC < 80 is antagonistic effect, 80 ≤ CTC ≤ 120 is additive effect, and CTC > 120 is synergistic effect.

[0052] Toxicity index (TI) = standard agent LC 50 / test agent LC 50 × 100

[0053] Actual mixed use toxicity index (ATI) = standard agent LC 50 / mixed agent LC 50 × 100

[0054] Theoretical mixed use toxicity index (TTI) = TI A × P A + TI B × P B

[0055] Co-toxicity coefficient (CTC) = actual mixed use toxicity index (ATI) / theoretical mixed use toxicity index (TTI) × 100

[0056] Wherein:

[0057] TI A represents the toxicity index of agent A;

[0058] TI BToxicity index representing the agent B;

[0059] P A Percentage of agent A in the mixture representing;

[0060] P B Percentage of agent B in the mixture representing;

[0061] Table 1 Joint toxicity results of each treatment

[0062]

[0063] The above table shows that the synergistic or additive effect of afidopyropen and bromocypermethrin is present in the range of 1:100 to 100:1. Among them, the synergistic effect is more obvious in the range of 1:25 to 75:1, especially in the range of 10:1 to 50:1.

[0064] II. Preparation Examples

[0065] Example 1: Suspension concentrate

[0066] Afidopyropen 5%, bromocypermethrin 5%, nonylphenol polyoxyethylene ether 6%, calcium dodecylbenzenesulfonate 3%, sodium carboxymethyl cellulose 5%, silicone 0.5%, ethylene glycol 4%, and water in balance.

[0067] The preparation method is to add each component into water, mix and stir, disperse by high-speed shearing, and grind to obtain a suspension concentrate.

[0068] Example 2: Suspension concentrate

[0069] Afidopyropen 20%, bromocypermethrin 1%, naphthalene sulfonate formaldehyde condensate sodium salt 9%, castor oil polyoxyethylene ether 8%, sodium carboxymethyl cellulose 6%, silicone 0.5%, propylene glycol 7%, and water in balance.

[0070] The preparation method is the same as example 1.

[0071] Example 3: Water dispersible granule

[0072] Afidopyropen 25%, bromocypermethrin 5%, naphthalene sulfonate formaldehyde condensate sodium salt 8%, castor oil polyoxyethylene ether 12%, gum arabic 4%, ammonium sulfate 6%, and kaolin in balance.

[0073] The preparation method is to mix and crush each component except the binder, then add the binder aqueous solution to granulate, dry to obtain a water dispersible granule.

[0074] Example 4: Water dispersible granule

[0075] Aforalan 10%, bromocyclen 1%, nonylphenol polyoxyethylene ether 5%, calcium dodecylbenzenesulfonate 6%, xanthan gum 5%, sodium sulfate 5%, kaolin remainder.

[0076] The preparation method is the same as in Example 3.

[0077] Finally, it should be noted that: the above examples are only used to illustrate the technical solutions of the present application, but not limited to them; although the present application has been described in detail with reference to the foregoing examples, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing examples, or make equivalent replacement for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A composition comprising afidopyropen and cyantraniliprol, characterized in that, The weight ratio of the afidopyropen to the bromopropylate is 1:25 to 100:

1.

2. The composition of claim 1, wherein, The weight ratio of the afidopyropen to the bromopropylate is 10:1 to 50:

1.

3. The composition according to claim 1 or 2, characterized in that, The composition further comprises an agriculturally acceptable adjuvant and / or carrier.

4. The composition of claim 3, wherein, The composition is formulated into a suspension concentrate, an aqueous emulsion, a wettable powder, a water dispersible granule, an emulsifiable concentrate or a microemulsion.

5. The composition of claim 4, wherein, The weight percentage of the active ingredient in the composition is 1-90%.

6. Use of a composition according to any one of claims 1 to 5 for the control of agricultural insects, characterized in that, The agricultural insect is Chilo suppressalis.

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