A hydrogel material and a preparation method and application thereof

Abstract

The application discloses a hydrogel material and a preparation method and application thereof. The hydrogel material comprises the following raw materials: an epoxy resin, a curing agent, an amino acid metal complex, a glucose oxidase solution and a precursor solution. The precursor solution comprises glucose, a crosslinking agent and a monomer. The hydrogel material has high adhesion, can be firmly combined on the surface of a substrate, and can improve the lubricity and antifouling effect of the substrate.

Description

Technical Field

[0001] This invention belongs to the field of hydrogel materials technology, specifically relating to a hydrogel material, its preparation method, and its application. Background Technology

[0002] The concept of "hydrogel" was first proposed in 1894. Since then, the development of hydrogels has been extremely rapid, with widespread research and applications ranging from drug delivery, tissue engineering, medical implants, wound dressings, and contact lenses to sensors, actuators, electronic devices, optical devices, batteries, water harvesters, and soft robotics. Meanwhile, the controllable modification of substrate surfaces using hydrogels as functional coatings has become a promising yet challenging topic, especially in the electronics and medical fields.

[0003] An ideal hydrogel coating preparation method aims to achieve two goals: strong adhesion to the substrate and the ability to adhere to substrates of any shape. Strong adhesion refers to a strong interaction between the hydrogel coating and the substrate surface, ensuring a good bond between the coating and the substrate and preventing detachment or breakage in practical applications. Existing hydrogel coating preparation methods, such as surface bridging, hydrogel coating methods, surface initiation methods, and surface-catalyzed free radical polymerization, are limited by issues such as the use of special monomers, single-substrate materials, fixed substrate shapes, and complex reaction conditions. These methods cannot yet meet market demands, therefore, there is an urgent need for new hydrogel coating preparation methods to adapt to current market requirements. Summary of the Invention

[0004] The present invention aims to at least solve one of the technical problems existing in the prior art. To this end, the present invention proposes a hydrogel material, its preparation method, and its application. The hydrogel material has high adhesion, and coating the substrate surface with the hydrogel material can improve the lubricity and anti-fouling effect of the substrate.

[0005] The present invention also proposes a method for preparing the above-mentioned hydrogel material.

[0006] The present invention also proposes a coating product.

[0007] The present invention also proposes an application.

[0008] According to a first aspect of the present invention, a hydrogel material is provided, the hydrogel material comprising the following raw materials: epoxy resin, curing agent, amino acid metal complex, glucose oxidase solution and precursor solution; wherein the precursor solution comprises glucose, crosslinking agent and monomer.

[0009] In some embodiments of the present invention, the mass ratio of the epoxy resin, curing agent, amino acid metal complex, precursor solution and glucose oxidase solution is (30-70):(30-70):(5-15):(5-15):1.

[0010] In some preferred embodiments of the present invention, the mass ratio of the epoxy resin, curing agent, amino acid metal complex, precursor solution and glucose oxidase solution is (40-60):(40-60):(8-12):(8-12):1.

[0011] In some more preferred embodiments of the present invention, the mass ratio of the epoxy resin, curing agent, amino acid metal complex, precursor solution and glucose oxidase solution is 50:50:10:10:1.

[0012] In some preferred embodiments of the present invention, the mass ratio of glucose, crosslinking agent and monomer is (80-120):(0.1-2):(80-200).

[0013] In some more preferred embodiments of the present invention, the mass ratio of glucose, crosslinking agent and monomer is (90-110):(0.2-1.6):(90-200).

[0014] In some more preferred embodiments of the present invention, the mass ratio of glucose, crosslinking agent and monomer is 100:(0.28-1.45):(92.1-198.75).

[0015] In some preferred embodiments of the present invention, the concentration of glucose oxidase in the glucose oxidase solution is 0.05 to 0.1 wt%.

[0016] In some more preferred embodiments of the present invention, the concentration of glucose oxidase in the glucose oxidase solution is 0.08 to 0.1 wt%.

[0017] In some embodiments of the present invention, the solvent of the glucose oxidase solution includes phosphate buffer.

[0018] In some embodiments of the present invention, the solvent of the precursor solution includes phosphate buffer.

[0019] In some embodiments of the present invention, the epoxy resin includes at least one of E-44, E-51, E-42, E-31, E-21 and E-20.

[0020] In some embodiments of the present invention, the curing agent includes a polyamide curing agent.

[0021] In some embodiments of the present invention, the amino acid metal complex includes at least one selected from ferrous glycine, ferrous histidine, molybdenum lysine, cobalt tryptophan, copper cysteine, manganese cysteine, and nickel tyrosine.

[0022] In some preferred embodiments of the present invention, the amino acid metal complex is ferrous glycine.

[0023] In some embodiments of the present invention, the crosslinking agent includes N,N-methylbisacrylamide or ethylene glycol dimethacrylate.

[0024] In some preferred embodiments of the present invention, the crosslinking agent is N,N-methylbisacrylamide.

[0025] In some embodiments of the present invention, the monomer includes at least one selected from N-hydroxyethylacrylamide, N,N-dimethylacrylamide, acrylic acid, poly(ethylene glycol) methacrylate, acrylamide, and sodium alginate.

[0026] According to a second aspect of the present invention, a method for preparing a hydrogel material as described in the first aspect of the present invention is provided, the method comprising the following steps:

[0027] S1: Mix the amino acid metal complex, epoxy resin, glucose oxidase solution and curing agent to obtain a mixture;

[0028] S2: Mix the mixture and precursor solution described in step S1, and react to obtain the hydrogel material.

[0029] In some embodiments of the present invention, the reaction time in step S2 is 10 to 70 minutes.

[0030] In some preferred embodiments of the present invention, the reaction time in step S2 is 15 to 60 minutes.

[0031] According to a third aspect of the invention, a coating product is provided, the coating product comprising a substrate and a hydrogel material as described in the first aspect of the invention coated on the surface of the substrate.

[0032] In some embodiments of the present invention, the substrate includes at least one of metal, plastic, ceramic, glass, rubber and wood.

[0033] In some preferred embodiments of the present invention, the metal includes, but is not limited to, iron, copper, and aluminum.

[0034] In some preferred embodiments of the present invention, the plastic includes, but is not limited to, acrylic.

[0035] In some preferred embodiments of the present invention, the rubber includes, but is not limited to, silicone.

[0036] In some embodiments of the present invention, the thickness of the hydrogel material coated on the surface of the substrate is 150–600 μm.

[0037] In some embodiments of the present invention, the adhesion strength of the hydrogel material coated on the surface of the substrate is 80 to 700 kPa.

[0038] According to a fourth aspect of the invention, the application of the hydrogel material as described in the first aspect of the invention is proposed in improving the lubricity and / or antifouling properties of a substrate.

[0039] The present invention has at least the following beneficial effects:

[0040] 1) The hydrogel material provided by the present invention can generate a general-purpose hydrogel coating with high adhesion in situ on the substrate surface by fixing ferrous glycinate and glucose oxidase on the surface of the epoxy resin-attached substrate, and then reacting with the precursor solution. The present invention provides a theoretical basis and technical support for the controllable modification of the surface of materials by using hydrogel as a functional coating.

[0041] 2) The hydrogel material provided by the present invention uses epoxy resin as the bottom layer. The epoxy resin reacts with other raw materials through a large number of epoxy groups carried by it to form a polymer network. The polymer network then undergoes topological adhesion with the substrate surface, which greatly improves the adhesion of the hydrogel to the substrate surface.

[0042] 3) The preparation method provided by the present invention has mild reaction conditions, does not require nitrogen purging of the precursor solution, is applicable to a variety of substrates of various shapes, and is suitable for a variety of monomers;

[0043] 4) The coating product provided by the present invention can improve the lubricity and anti-fouling properties of the substrate surface by coating the surface with the above-mentioned hydrogel material, and can be widely used in actual production. Attached Figure Description

[0044] The present invention will be further described below with reference to the accompanying drawings and embodiments, wherein:

[0045] Figure 1 This is a SEM image of the cross-section of the hydrogel coating of the coated product in the experimental example of the present invention; the scale bar is 10 μm.

[0046] Figure 2 This is a graph showing the test results of the thickness of the hydrogel coating on different substrates in the experimental examples of this invention;

[0047] Figure 3The graph shows the test results of the hydrogel coating thickness of the coated products obtained by different polymer monomers in the experimental examples of this invention;

[0048] Figure 4 The figures show the FTIR results of the coated products prepared by different polymer monomers in the experimental examples of this invention; wherein, Figure A shows the FTIR spectra of the hydrogel coating prepared by AA+PEGMA, PEGMA monomer and AA monomer, and Figure B shows the FTIR spectra of the hydrogel coating prepared by HEAA+SA, HEAA monomer and SA monomer.

[0049] Figure 5 The figures show the adhesion strength test results of the hydrogel coatings of the coated products obtained by different polymer monomers in the experimental examples of this invention; wherein, Figure A is the adhesion test curve, and Figure B is the adhesion strength calculated based on the curve in Figure A;

[0050] Figure 6 The figure shows the test results of the lubrication performance of the hydrogel coating in the test examples of this invention;

[0051] Figure 7 This is a graph showing the test results of the hydrogel coating's resistance to biofouling in the experimental examples of this invention. Detailed Implementation

[0052] The following will describe the concept and technical effects of the present invention clearly and completely with reference to embodiments, so as to fully understand the purpose, features and effects of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are all within the scope of protection of the present invention.

[0053] Example 1

[0054] This embodiment provides a hydrogel material, and the preparation method of the hydrogel specifically includes the following steps:

[0055] 1) Weigh the following raw materials according to the following weight proportions: 50 parts epoxy resin E-44, 50 parts curing agent 605 (purchased from Migazan, item number 610189137324), 1 part glucose oxidase (GOD, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.) solution and 10 parts ferrous glycine; mix the above raw materials to obtain a mixture; the GOD solution is a PBS buffer solution containing 0.1 wt% PBS (0.2 M, pH=5);

[0056] 2) Weigh 92.1 parts by weight of N-hydroxyethyl acrylamide (HEAA), 0.28 parts by weight of N,N-methylbisacrylamide (MBAA) and 100 parts by weight of glucose and dissolve them in 1000 parts by weight of PBS buffer to obtain the precursor solution;

[0057] 3) Mix the mixture obtained in step 1) and the precursor solution obtained in step 2) and react for 15 minutes to obtain the hydrogel material.

[0058] Example 2

[0059] This embodiment provides a hydrogel material, which is prepared in the same way as in Example 1, except that in step 2), 92.1 parts by mass of HEAA is replaced with 106.6 parts by mass of acrylamide (AM) and the amount of MBAA is adjusted to 0.32 parts by mass.

[0060] Example 3

[0061] This embodiment provides a hydrogel material, which is prepared in the same way as in Example 1, except that 92.1 parts by mass of HEAA in step 2) is replaced with 149.7 parts by mass of N,N-dimethylacrylamide (DMAA) and the amount of MABAA is adjusted to 0.74 parts by mass.

[0062] Example 4

[0063] This embodiment provides a hydrogel material, which is prepared in the same way as in Example 1, except that in step 2), 92.1 parts by mass of HEAA is replaced with 33.15 parts by mass of acrylic acid (AA) and 165.6 parts by mass of poly(ethylene glycol) methacrylate (PEGMA), and the amount of MABA is adjusted to 0.99 parts by mass.

[0064] Example 5

[0065] This embodiment provides a hydrogel material. The preparation method of the hydrogel material is the same as that of Example 1, except that in step 2), 92.1 parts by mass of HEAA is replaced with 115.13 parts by mass of HEAA and 30 parts by mass of sodium alginate (SA), the amount of MBAA is adjusted to 1.45 parts by mass, and the reaction time in step 3) is adjusted to 60 min.

[0066] Example 6

[0067] This embodiment provides a coated product, which is composed of an acrylic substrate (25mm × 50mm) and the hydrogel material provided in Example 1. The specific preparation method of the coated product includes the following steps:

[0068] 1) Weigh the following raw materials according to the following weight: 50 parts epoxy resin E-44, 50 parts curing agent 605 (purchased from Mijiazhan, item number 610189137324) and 10 parts ferrous glycine; mix the above raw materials evenly, coat the mixture evenly on the acrylic substrate, and dry it in a 70℃ oven for 30 minutes to obtain the pretreated substrate;

[0069] 2) Weigh 1 part by weight of glucose oxidase (GOD) and dissolve it in 1000 parts by weight of PBS buffer (0.2M, pH=5) to obtain a GOD solution; take 1 part by weight of GOD solution and drop it onto the pretreated substrate obtained in step 1), let it stand for 1 hour, and then rinse the substrate surface with PBS to obtain a substrate covered with GOD.

[0070] 3) Weigh 92.1 parts by weight of N-hydroxyethyl acrylamide (HEAA), 0.28 parts by weight of N,N-methylbisacrylamide (MBAA) and 100 parts by weight of glucose and dissolve them in 1000 parts by weight of PBS buffer to obtain the precursor solution;

[0071] 4) Take 10 parts by weight of the precursor solution obtained in step 3), and put the substrate covered with GOD obtained in step 2) into the precursor solution and react for 15 minutes to obtain the coated product coated with high adhesion general-purpose hydrogel material.

[0072] Example 7

[0073] This embodiment provides a coating product composed of a silicone substrate and the hydrogel material provided in Example 1. The specific preparation method is the same as in Example 6, except that the acrylic substrate is replaced with a silicone substrate.

[0074] Example 8

[0075] This embodiment provides a coating product composed of a glass substrate and the hydrogel material provided in Example 1. The specific preparation method is the same as in Example 6, except that the acrylic substrate is replaced with a glass substrate.

[0076] Example 9

[0077] This embodiment provides a coating product composed of an iron substrate and the hydrogel material provided in Example 1. The specific preparation method is the same as in Example 6, except that the acrylic substrate is replaced with an iron substrate.

[0078] Example 10

[0079] This embodiment provides a coating product composed of a copper substrate and the hydrogel material provided in Example 1. The specific preparation method is the same as in Example 6, except that the acrylic substrate is replaced with a copper substrate.

[0080] Example 11

[0081] This embodiment provides a coating product composed of an aluminum substrate and the hydrogel material provided in Example 1. The specific preparation method is the same as in Example 6, except that the acrylic substrate is replaced with an aluminum substrate.

[0082] Example 12

[0083] This embodiment provides a coating product composed of an acrylic substrate and the hydrogel material provided in Example 2. The specific preparation method is the same as that in Example 6, except that 92.1 parts by weight of HEAA in step 3) is replaced with 106.6 parts by weight of acrylamide (AM) and the amount of MBAA is adjusted to 0.32 parts by weight.

[0084] Example 13

[0085] This embodiment provides a coating product composed of an acrylic substrate and the hydrogel material provided in Example 3. The specific preparation method is the same as that in Example 6, except that 92.1 parts by weight of HEAA in step 3) is replaced with 149.7 parts by weight of N,N-dimethylacrylamide (DMAA) and the amount of MABAA is adjusted to 0.74 parts by weight.

[0086] Example 14

[0087] This embodiment provides a coating product composed of an acrylic substrate and the hydrogel material provided in Example 4. The specific preparation method is the same as that in Example 6, except that 92.1 parts by weight of HEAA in step 3) is replaced with 33.15 parts by weight of acrylic acid (AA) and 165.6 parts by weight of poly(ethylene glycol) methacrylate (PEGMA), and the amount of MABA is adjusted to 0.99 parts by weight.

[0088] Example 15

[0089] This embodiment provides a coating product composed of an acrylic substrate and the hydrogel material provided in Example 5. The specific preparation method is the same as that in Example 6; the only difference is that 92.1 parts by mass of HEAA in step 3) is replaced with 115.13 parts by mass of HEAA and 30 parts by mass of sodium alginate (SA), and the amount of MBAA is adjusted to 1.45 parts by mass, and the reaction time in step 4) is adjusted to 60 min.

[0090] Example 16

[0091] This embodiment provides a coating product, which is composed of a 50mm×20mm×1mm PVC substrate and the hydrogel material provided in Example 1. The specific preparation method is the same as in Example 6; the only difference is that the acrylic substrate is replaced with a PVC substrate, and the reaction time in step 4) is 45min.

[0092] Example 17

[0093] This embodiment provides a coating product, which is composed of a 50mm×20mm×1mm PVC substrate and the hydrogel material provided in Example 2. The specific preparation method is the same as in Example 12; the only difference is that the acrylic substrate is replaced with a PVC substrate, and the reaction time in step 4) is 45 minutes.

[0094] Example 18

[0095] This embodiment provides a coating product, which is composed of a 50mm×20mm×1mm PVC substrate and the hydrogel material provided in Example 3. The specific preparation method is the same as in Example 13; the only difference is that the acrylic substrate is replaced with a PVC substrate, and the reaction time in step 4) is 45min.

[0096] Example 19

[0097] This embodiment provides a coating product, which is composed of a 50mm×20mm×1mm PVC substrate and the hydrogel material provided in Example 4. The specific preparation method is the same as in Example 14; the only difference is that the acrylic substrate is replaced with a PVC substrate, and the reaction time in step 4) is 45 minutes.

[0098] Example 20

[0099] This embodiment provides a coating product, which is composed of a 50mm×20mm×1mm PVC substrate and the hydrogel material provided in Example 5. The specific preparation method is the same as that in Example 15; the only difference is that the acrylic substrate is replaced with a PVC substrate.

[0100] Example 21

[0101] This embodiment provides a coated product composed of a glass substrate and the hydrogel material provided in Example 4. The specific preparation method is the same as in Example 14, except that the acrylic substrate is replaced with a glass substrate. Experimental Example

[0102] This experiment tested several characterization parameters of the hydrogel materials in the coated products prepared in Examples 6-20, including the microstructure characterized by scanning electron microscopy (SEM), the thickness of the hydrogel materials on different substrate surfaces, the thickness of the hydrogel materials with different raw material ratios, Fourier transform infrared spectroscopy (FTIR) characterization, and adhesion strength. The specific experimental methods and results are as follows:

[0103] 1. Characterizing coated products using SEM:

[0104] The coated product prepared in Example 6 was frozen in liquid nitrogen, broken into pieces, and dried in a vacuum freeze dryer for 12 hours. The cross-section of the hydrogel coating was observed and photographed using SEM. The results are as follows: Figure 1As shown.

[0105] Depend on Figure 1 It can be seen that the hydrogel coating is tightly bonded to the substrate, and part of the hydrogel extends into the epoxy / ferrous glycinate / glucose oxidase layer. The surface hydrogel coating is firmly attached to the substrate by bonding with the epoxy / ferrous glycinate / glucose oxidase layer.

[0106] 2. Detect the thickness of the hydrogel coating on coated products prepared from different substrates:

[0107] The thickness of the hydrogel on the surface of the coated products prepared in Examples 6-11 was measured using a polarizing microscope, and the results are as follows: Figure 2 As shown in Table 1, the substrates used for the coated products prepared in Examples 6 to 11 are shown in Table 1.

[0108] Table 1. Substrates used in the coated products obtained in Examples 6-11

[0109]

[0110]

[0111] Depend on Figure 2 It can be seen that when the hydrogel material provided in Example 1 of this invention is coated on the surface of different types of substrates, the thickness of the resulting hydrogel coating is relatively stable, basically maintained at 400-500 μm. This indicates that the hydrogel material provided by this invention can be successfully coated on the surface of various substrates and is suitable for widespread application in actual production.

[0112] 3. Detect the thickness of the hydrogel coating on the coated products prepared with different polymer monomers:

[0113] The thickness of the hydrogel on the surface of the coated products prepared in Examples 6 and 12-15 was detected using a polarizing microscope, and the results are as follows: Figure 3 As shown in Table 2, the formulations of the precursor solutions used in the coating products prepared in Examples 6 and 12-15 are shown in Table 2.

[0114] Table 2. Formulations of the precursor solutions used in the coating products obtained in Examples 6 and 12-15.

[0115]

[0116] Depend on Figure 3 It can be seen that hydrogel coatings can be successfully prepared using the above monomers, and the thickness of the coating varies slightly depending on the monomer structure.

[0117] 4. Characterize the coated product using FTIR:

[0118] Fourier transform infrared spectroscopy (Nicoleti S50, Thermo Fisher Scientific, USA) was used in the wavelength range of 400–4000 cm⁻¹. -1 The chemical structures of the freeze-dried epoxy / ferrous glycine / glucose oxidase layer and hydrogel coating were analyzed.

[0119] Depend on Figure 4 It can be seen that the FTIR spectrum shows 1250 cm⁻¹ -1 The point is an in-plane bending of the PAA due to the tension of CO and the coupling of OH, 1110cm. -1 The CO stretching peak of PEGMA is located at 1542 cm⁻¹. -1 The location is the NH bending vibration of HEAA (amide II) and 1050 cm. -1 The COC stretching of SA at the site confirms that the present invention successfully prepared a coated product with a hydrogel layer using polymeric monomers AA+PEGMA and HEAA+SA.

[0120] 5. Testing the adhesion of hydrogel coatings on products prepared with different polymer monomers:

[0121] The coated products obtained in Examples 16-20 were aged at room temperature for 3 hours, and then the adhesion strength of the gel coating was tested using an electronic universal testing machine with an lap shear test. The hydrogel coating was pulled at a speed of 5 mm / min until failure, and the adhesion strength was calculated by dividing the maximum strength by the adhesive area. The formulations of the precursor solutions used in the coated products obtained in Examples 16-20 are shown in Table 3. The results are as follows: Figure 5 As shown.

[0122] Table 3. Formulations of the precursor solutions used in the coating products obtained in Examples 16-20

[0123]

[0124] Depend on Figure 5 It can be seen that the hydrogel coatings prepared by using different polymer monomers have different adhesion strengths. Among them, the adhesion strength of the PDMAA hydrogel coating reaches 686 kPa, indicating that the high-adhesion general-purpose hydrogel material prepared by the present invention has higher adhesion strength.

[0125] 6. Test the lubrication capability of the hydrogel coating:

[0126] The coated product obtained in Example 12 was used as the test group, and the acrylic substrate was used as the control group. Both groups were placed horizontally on an experimental table at a 5° angle to the laboratory. A 50g weight was then placed at one end of each group. The results are as follows: Figure 6 As shown.

[0127] Depend on Figure 6 It can be seen that the weights in the coated test group slipped, while the weights in the control group remained stationary. These results demonstrate that the hydrogel material provided by this invention has excellent lubrication properties, and coating the substrate with this hydrogel material can reduce the friction on the substrate surface.

[0128] 7. Testing the biofouling resistance of the hydrogel coating:

[0129] Bovine serum protein was used as a biofouling agent. The coated products prepared in Examples 8 and 21 were used as the test group, and the glass substrate was used as the control group for biofouling resistance testing. The biofouling resistance test specifically included the following steps:

[0130] 1) 100 μL of bovine serum albumin (BSA-Cy5.5) labeled with sulfocyanate 5.5 dye was coated onto a glass slide and then coated onto the hydrogel coatings (size: 25 mm × 50 mm) prepared in Example 8 and Example 21, respectively.

[0131] 2) After standing for 4 hours, rinse these samples and wash them with deionized water at least three times to remove any unattached BSA from the surface;

[0132] 3) The coating surface was observed using a laser confocal microscope. ImageJ was used to automatically identify the percentage of the coating surface area occupied by proteins, which was further used to evaluate the anti-biofouling performance of the hydrogel coating. The results are as follows: Figure 7 As shown.

[0133] Depend on Figure 7 It is known that the hydrogel material prepared by the present invention has excellent resistance to biofouling. Coating the surface of the substrate with this hydrogel material can significantly reduce the adsorption of proteins on the coating surface, thereby improving the resistance to biofouling of the coated product. The hydrogel material provided by the present invention is suitable for widespread application in antibacterial or antimicrobial materials.

[0134] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments, and various changes can be made within the scope of knowledge possessed by those skilled in the art without departing from the spirit of the present invention. Furthermore, the embodiments of the present invention and the features thereof can be combined with each other unless otherwise specified.

Claims

1. A hydrogel material, characterized in that, The hydrogel material comprises the following raw materials: epoxy resin, curing agent, amino acid metal complex, glucose oxidase solution, and precursor solution; The precursor solution comprises glucose, a cross-linking agent, a monomer, and a phosphate buffer solution; The mass ratio of the epoxy resin, curing agent, amino acid metal complex, precursor solution and glucose oxidase solution is (30~70):(30~70):(5~15):(5~15):1; The mass ratio of glucose, cross-linking agent, monomer and phosphate buffer is (80~120):(0.1~2):(80~200):1000; The concentration of glucose oxidase in the glucose oxidase solution is 0.05~0.1 wt%; The monomer includes at least one of N-hydroxyethylacrylamide, N,N-dimethylacrylamide, acrylic acid, poly(ethylene glycol) methacrylate, and acrylamide.

2. The hydrogel material according to claim 1, characterized in that, The epoxy resin includes at least one of E-44, E-51, E-42, E-31, E-21 and E-20.

3. The hydrogel material according to claim 1, characterized in that, The curing agent includes a polyamide curing agent.

4. The hydrogel material according to claim 1, characterized in that, The amino acid metal complex includes at least one of ferrous glycine, ferrous histidine, molybdenum lysine, cobalt tryptophan, copper cysteine, manganese cysteine, and nickel tyrosine.

5. The hydrogel material according to claim 1, characterized in that, The crosslinking agent includes N,N-methylenebisacrylamide or ethylene glycol dimethacrylate.

6. A method for preparing the hydrogel material as described in any one of claims 1 to 5, characterized in that, The preparation method includes the following steps: S1: Mix the amino acid metal complex, epoxy resin, glucose oxidase solution and curing agent to obtain a mixture; S2: Mix the mixture and precursor solution described in step S1, and react to obtain the hydrogel material.

7. A coated product, characterized in that, The coated product includes a substrate and a hydrogel material as described in any one of claims 1 to 5 coated on the surface of the substrate.

8. The use of the hydrogel material as described in any one of claims 1 to 5 in improving the lubricity and / or antifouling properties of a substrate.

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