A traditional chinese medicine composition for treating hyperhidrosis and application thereof

Abstract

The present application relates to a kind of traditional Chinese medicine composition for treating hyperhidrosis and its application, it is related to traditional Chinese medicine technical field, by weight parts, the traditional Chinese medicine composition for treating hyperhidrosis is composed of the following raw materials: flat lying chrysanthemum sanqi 54~78 parts and Sedum lineare 15~28 parts.The present application uses flat lying chrysanthemum sanqi and Sedum lineare in appropriate proportion, and they are mutually synergistic, and a kind of traditional Chinese medicine composition for treating hyperhidrosis is prepared by mutual action, curative effect is remarkable, and compatibility is simple, provide a new means for the treatment of hyperhidrosis patient, with practical application value.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating hyperhidrosis and application thereof. BACKGROUND

[0002] Hyperhidrosis refers to abnormal increase of local or systemic skin sweating under normal environmental temperature and conditions, and is mostly seen in palm, sole, armpit, groin and other body parts, which seriously affects normal life and work of patients. There are two types of treatments for hyperhidrosis, i.e. surgical treatment and drug treatment, but the surgical treatment has high risk and may not effectively improve sweating after operation, and the effect of drug treatment is poor, which is often unsatisfactory.

[0003] Gynura procumbens (Lour.) Merr. is a climbing herbaceous plant of Gynura procumbens (Lour.) Merr. of Asteraceae. As a traditional Chinese medicinal material, the dry rhizome of Gynura procumbens (Lour.) Merr. is used as a medicinal part, has the effects of resolving blood stasis, stopping bleeding, and relieving swelling and pain, and is mainly used for treating wind-dampness impediment syndrome, and traumatic injury in clinic.

[0004] Sedum emarginatum Migo is a perennial herb of Crassulaceae, and the whole grass and rhizome can be used as a medicine, has the effects of clearing heat and resolving toxicity, cooling blood and stopping bleeding, and dampness, and can be used for treating hepatitis, dysentery, hematemesis, epistaxis, hematochezia and other diseases.

[0005] At present, there is no report on combination of Gynura procumbens (Lour.) Merr. and Sedum emarginatum Migo for treating hyperhidrosis in the prior art. SUMMARY

[0006] In order to solve the above problems, the present application provides a traditional Chinese medicine composition for treating hyperhidrosis and application thereof.

[0007] In the first aspect, the present application provides a traditional Chinese medicine composition for treating hyperhidrosis, which is composed of the following raw materials in weight parts:

[0008] Gynura procumbens (Lour.) Merr. 54-78 parts and Sedum emarginatum Migo 15-28 parts.

[0009] Further, the traditional Chinese medicine composition for treating hyperhidrosis is composed of the following raw materials in weight parts:

[0010] Gynura procumbens (Lour.) Merr. 67.5 parts and Sedum emarginatum Migo 22 parts.

[0011] Further, the preparation method of the traditional Chinese medicine composition for treating hyperhidrosis comprises the following steps:

[0012] Gynura procumbens (Lour.) Merr. and Sedum emarginatum Migo are crushed and mixed to obtain a mixture.

[0013] adding the mixture into water to carry out the reduced pressure reflux extraction, and then carrying out the concentration and drying of the extraction liquid to obtain the traditional Chinese medicine composition.

[0014] Further, the step of adding the mixture into water to carry out the reduced pressure reflux extraction, and then carrying out the concentration and drying of the extraction liquid to obtain the traditional Chinese medicine composition comprises the following process:

[0015] adding the mixture into water to carry out the first reduced pressure reflux extraction for 1-3 hours under the pressure of 4-8 kPa and the temperature of 45-50 ℃, and then filtering to obtain the first extraction liquid and the residue;

[0016] adding the residue into water in the same volume as the first extraction liquid, and then carrying out the second reduced pressure reflux extraction for 1-3 hours under the pressure of 15-20 kPa and the temperature of 61-65 ℃, and then filtering to obtain the second extraction liquid;

[0017] combining and concentrating the first extraction liquid and the second extraction liquid, and then drying to obtain the traditional Chinese medicine composition.

[0018] Further, the working parameters of the first reduced pressure reflux extraction include the pressure of 6 kPa and the temperature of 47 ℃.

[0019] Further, the working parameters of the second reduced pressure reflux extraction include the pressure of 18 kPa and the temperature of 63 ℃.

[0020] Further, the weight-volume ratio of the initial adding amount of the mixture and the water is 1:(10-20) in g / ml.

[0021] In the second aspect, the application provides an application of the traditional Chinese medicine composition for treating hyperhidrosis in any one of the first aspect in the preparation of a medicine for treating hyperhidrosis.

[0022] In the third aspect, the application provides a liquid preparation for treating hyperhidrosis, and the functional component of the liquid preparation is the traditional Chinese medicine composition for treating hyperhidrosis in any one of the first aspect.

[0023] Further, the liquid preparation for treating hyperhidrosis comprises the following components in weight percentage:

[0024] The traditional Chinese medicine composition for treating hyperhidrosis in any one of the first aspect is 5-45%, and the ethanol is 10-35%; and the balance is water.

[0025] Further, the liquid preparation for treating hyperhidrosis comprises the following components in weight percentage:

[0026] The traditional Chinese medicine composition for treating hyperhidrosis in any one of the first aspect is 32%, and the ethanol is 18%; and the balance is water.

[0027] The above technical solution provided by the present application has at least the following advantages compared with the prior art:

[0028] The present application provides a traditional Chinese medicine composition for treating hyperhidrosis. The traditional Chinese medicine composition is prepared by using appropriate proportions of Leonticola japonicus and Saxifraga stolonifera. The two components synergize with each other to treat hyperhidrosis. The traditional Chinese medicine composition has a significant effect and is simple to prepare. It provides a new method for treating hyperhidrosis and has practical application value. DETAILED DESCRIPTION

[0029] The technical solutions of the present application will be described clearly and completely below. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of the present application.

[0030] Unless otherwise specified, all the materials, reagents, instruments and equipment used in the present application can be purchased or prepared by existing methods.

[0031] In a first aspect, the present application provides a traditional Chinese medicine composition for treating hyperhidrosis. The traditional Chinese medicine composition comprises the following components by weight:

[0032] Leonticola japonicus 54-78 parts and Saxifraga stolonifera 15-28 parts.

[0033] The present application provides a traditional Chinese medicine composition for treating hyperhidrosis. The traditional Chinese medicine composition is prepared by using appropriate proportions of Leonticola japonicus and Saxifraga stolonifera. The two components synergize with each other to treat hyperhidrosis. The traditional Chinese medicine composition has a significant effect and is simple to prepare. It provides a new method for treating hyperhidrosis and has practical application value.

[0034] In some embodiments, the traditional Chinese medicine composition for treating hyperhidrosis comprises the following components by weight:

[0035] Leonticola japonicus 67.5 parts and Saxifraga stolonifera 22 parts.

[0036] In some embodiments, the preparation method of the traditional Chinese medicine composition for treating hyperhidrosis comprises the following steps:

[0037] Leonticola japonicus and Saxifraga stolonifera are crushed and mixed to obtain a mixture;

[0038] The mixture is added into water to perform reduced pressure reflux extraction, and then the extraction liquid is concentrated and dried to obtain the traditional Chinese medicine composition.

[0039] In some embodiments, the step of adding the mixture into water to perform reduced pressure reflux extraction, and then concentrating and drying the extraction liquid to obtain the traditional Chinese medicine composition comprises the following processes:

[0040] The mixture is added into water to perform first reduced pressure reflux extraction at a pressure of 4-8 kPa and a temperature of 45-50℃ for 1-3 hours, and then filtered to obtain a first extraction liquid and a residue;

[0041] Water with the same volume as the first extraction liquid is added into the residue, and then second reduced pressure reflux extraction is performed at a pressure of 15-20 kPa and a temperature of 61-65℃ for 1-3 hours, and then filtered to obtain a second extraction liquid;

[0042] The first extraction liquid and the second extraction liquid are combined, concentrated, and dried to obtain the traditional Chinese medicine composition.

[0043] The applicant finds through a large number of experiments that the traditional Chinese medicine composition obtained by reduced pressure reflux extraction under the above specific conditions has more remarkable therapeutic effect on hyperhidrosis.

[0044] In some embodiments, the working parameters of the first reduced pressure reflux extraction include a pressure of 6 kPa and a temperature of 47℃.

[0045] In some embodiments, the working parameters of the second reduced pressure reflux extraction include a pressure of 18 kPa and a temperature of 63℃.

[0046] In some embodiments, the weight-volume ratio of the initial amount of the mixture and the water is 1:(10-20) in g / ml.

[0047] It should be noted that the component raw materials involved in the traditional Chinese medicine composition for treating hyperhidrosis provided by the present application can be directly used as commercially available products or self-made by using the existing preparation process if there is no special limitation or instruction. Meanwhile, the preparation process steps and parameters involved can be performed according to the existing traditional Chinese medicine extraction process or using the existing equipment if there is no special limitation or instruction, and the present application document will not be described one by one.

[0048] In a second aspect, based on the overall inventive concept, the present application provides a use of the traditional Chinese medicine composition for treating hyperhidrosis according to any one of the first aspect in the preparation of a medicine for treating hyperhidrosis.

[0049] The treatment hyperhidrosis traditional Chinese medicine composition provided by the present application can be prepared into a treatment hyperhidrosis medicine as a medicinal efficacy component according to an existing medicine preparation process, with appropriate medicinal adjuvants, and the dosage form of the treatment hyperhidrosis medicine includes, but is not limited to, liquid preparation, solid powder, capsule, tablet and the like.

[0050] In a third aspect, based on the same inventive concept, the present application provides a liquid preparation for treating hyperhidrosis, wherein the efficacy component of the liquid preparation is the treatment hyperhidrosis traditional Chinese medicine composition according to any one of the first aspect.

[0051] The liquid preparation for treating hyperhidrosis provided by the present application has good curative effect and is convenient to use, and is especially suitable for local hyperhidrosis such as palm and sole. Meanwhile, the technical solution is realized based on the treatment hyperhidrosis traditional Chinese medicine composition according to any one of the first aspect, and thus at least has all the beneficial effects brought by the technical solutions of the above-mentioned embodiments, which will not be repeated here.

[0052] In some specific embodiments, the liquid preparation for treating hyperhidrosis includes the following components in percentage by weight:

[0053] The treatment hyperhidrosis traditional Chinese medicine composition according to any one of the first aspect is 5-45%, ethanol is 10-35%, and the rest is water.

[0054] The treatment hyperhidrosis traditional Chinese medicine composition according to any one of the first aspect is used as a medicinal efficacy component, and appropriate ethanol is added to promote the penetration of the medicine into the skin and enhance the curative effect.

[0055] In some specific embodiments, the liquid preparation for treating hyperhidrosis includes the following components in percentage by weight:

[0056] The treatment hyperhidrosis traditional Chinese medicine composition according to any one of the first aspect is 32%, ethanol is 18%, and the rest is water.

[0057] It should be noted that the operation steps involved in the preparation method of the liquid preparation for treating local hyperhidrosis such as palm and sole provided by the present application can be performed according to the existing liquid preparation preparation process or by using existing equipment without special limitation or description, which will not be repeated here.

[0058] The present application will be further described in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present application and not to limit the scope of the present application. The experimental methods in the following examples without specific conditions are generally determined according to national standards. If there is no corresponding national standard, the international standard, the conventional condition or the condition suggested by the manufacturer is used.

[0059] Example 1

[0060] The example provides a traditional Chinese medicine composition for treating hyperhidrosis, which is composed of the following raw materials in parts by weight: Gynura japonica 67.5 parts and Sedum lineare 22 parts.

[0061] The preparation method of the traditional Chinese medicine composition for treating hyperhidrosis comprises the following steps:

[0062] Step (1): Gynura japonica dried rhizome and Sedum lineare dried whole plant are crushed and mixed to obtain a mixture;

[0063] Step (2): the mixture obtained in step (1) and water are mixed in a weight to volume ratio of 1:15 in g / ml, and then first reduced pressure reflux extraction is carried out at a pressure of 6 kPa and a temperature of 47℃ for 1.5 hours, followed by filtration to obtain a first extract and a residue; the same volume of water as the first extract is added to the residue, and then second reduced pressure reflux extraction is carried out at a pressure of 18 kPa and a temperature of 63℃ for 1.5 hours, followed by filtration to obtain a second extract; the first extract and the second extract are combined and concentrated, and then dried to obtain the traditional Chinese medicine composition.

[0064] Example 2

[0065] The example provides a traditional Chinese medicine composition for treating hyperhidrosis, which is composed of the following raw materials in parts by weight: Gynura japonica 67.5 parts and Sedum lineare 22 parts.

[0066] The preparation method of the traditional Chinese medicine composition for treating hyperhidrosis comprises the following steps:

[0067] Step (1): Gynura japonica dried rhizome and Sedum lineare dried whole plant are crushed and mixed to obtain a mixture;

[0068] Step (2): the mixture obtained in step (1) and water are mixed in a weight to volume ratio of 1:15 in g / ml, and then first reduced pressure reflux extraction is carried out at a pressure of 6 kPa and a temperature of 47℃ for 1.5 hours, followed by filtration to obtain a first extract and a residue; the same volume of water as the first extract is added to the residue, and then second reduced pressure reflux extraction is carried out at a pressure of 18 kPa and a temperature of 63℃ for 1.5 hours, followed by filtration to obtain a second extract; the first extract and the second extract are combined and concentrated, and then dried to obtain the traditional Chinese medicine composition.

[0069] Example 3

[0070] The example provides a traditional Chinese medicine composition for treating hyperhidrosis, which is composed of the following raw materials in parts by weight: Gynura japonica 67.5 parts and Sedum lineare 22 parts.

[0071] The preparation method of the traditional Chinese medicine composition for treating hyperhidrosis comprises the following steps:

[0072] Step (1): dry rhizomes of Gynura divaricata and dry whole plants of Saxifraga stolonifera are crushed and mixed to obtain a mixture;

[0073] Step (2): the mixture obtained in step (1) and water are mixed according to a weight-to-volume ratio of 1:15 in g / ml, and then first reduced-pressure reflux extraction is performed at a pressure of 8 kPa and a temperature of 50°C for 1.5 hours, followed by filtration to obtain a first extract and a residue; the same volume of water as the first extract is added to the residue, and then second reduced-pressure reflux extraction is performed at a pressure of 20 kPa and a temperature of 65°C for 1.5 hours, followed by filtration to obtain a second extract; the first extract and the second extract are combined and concentrated, and then dried to obtain the traditional Chinese medicine composition.

[0074] Comparative Example 1

[0075] This example provides a traditional Chinese medicine for treating hyperhidrosis and a preparation method thereof, which is different from Example 1 only in that the amount of Saxifraga stolonifera is adjusted to 0 parts (i.e., no Saxifraga stolonifera is added), and the amount of Gynura divaricata is adjusted to 89.5 parts; the rest of the steps and parameters are the same.

[0076] The preparation method of the traditional Chinese medicine for treating hyperhidrosis comprises the following steps:

[0077] Step (1): dry rhizomes of Gynura divaricata are crushed to obtain a raw material;

[0078] Step (2): the raw material obtained in step (1) and water are mixed according to a weight-to-volume ratio of 1:15 in g / ml, and then first reduced-pressure reflux extraction is performed at a pressure of 6 kPa and a temperature of 47°C for 1.5 hours, followed by filtration to obtain a first extract and a residue; the same volume of water as the first extract is added to the residue, and then second reduced-pressure reflux extraction is performed at a pressure of 18 kPa and a temperature of 63°C for 1.5 hours, followed by filtration to obtain a second extract; the first extract and the second extract are combined and concentrated, and then dried to obtain the traditional Chinese medicine.

[0079] Comparative Example 2

[0080] This example provides a traditional Chinese medicine for treating hyperhidrosis and a preparation method thereof, which is different from Example 1 only in that the amount of Gynura divaricata is adjusted to 0 parts (i.e., no Gynura divaricata is added), and the amount of Saxifraga stolonifera is adjusted to 89.5 parts; the rest of the steps and parameters are the same.

[0081] The preparation method of the traditional Chinese medicine for treating hyperhidrosis comprises the following steps:

[0082] Step (1): crushing the dried whole plant of Saxifraga stolonifera L. to obtain raw material;

[0083] Step (2): mixing the raw material obtained in step (1) and water in a weight-volume ratio of 1:15 (in g / ml), then performing first reduced-pressure reflux extraction at a pressure of 6 kPa and a temperature of 47℃ for 1.5 hours, and then filtering to obtain a first extract and a residue; adding water to the residue in an amount equal to that of the first extract, and then performing second reduced-pressure reflux extraction at a pressure of 18 kPa and a temperature of 63℃ for 1.5 hours, and then filtering to obtain a second extract; combining and concentrating the first extract and the second extract, and then drying to obtain the traditional Chinese medicine.

[0084] Comparative Example 3

[0085] This example provides a traditional Chinese medicine composition for treating hyperhidrosis and a preparation method thereof, which is different from Example 1 only in that the amount of Saxifraga stolonifera L. is adjusted to 40 parts (i.e., the amount of Saxifraga stolonifera L. is relatively excessive); the other steps and parameters are the same.

[0086] Comparative Example 4

[0087] This example provides a traditional Chinese medicine composition for treating hyperhidrosis and a preparation method thereof, which is different from Example 1 only in that the pressure for first reduced-pressure reflux extraction in step (2) is adjusted to 30 kPa, the temperature is adjusted to 72℃, the pressure for second reduced-pressure reflux extraction is adjusted to 45 kPa, and the temperature is adjusted to 82℃; the other steps and parameters are the same.

[0088] Test Example

[0089] This example tests the antiperspirant effect of the products obtained in the examples and comparative examples as test samples.

[0090] Preparation and numbering of test sample liquid preparation: water is used as a solvent, and the test sample and ethanol are added to water to prepare a liquid preparation (by weight percentage, the liquid preparation contains 32wt% of the test sample, 18wt% of ethanol, and 50wt% of water); the liquid preparation number of the test sample of Example 1 is liquid preparation 1, the liquid preparation number of the test sample of Example 2 is liquid preparation 2, the liquid preparation number of the test sample of Example 3 is liquid preparation 3, the liquid preparation number of the test sample of Comparative Example 1 is liquid preparation 4, the liquid preparation number of the test sample of Comparative Example 2 is liquid preparation 5, the liquid preparation number of the test sample of Comparative Example 3 is liquid preparation 6, and the liquid preparation number of the test sample of Comparative Example 4 is liquid preparation 7.

[0091] Test animals and grouping: SD rats weighing 180-220g, first clean the footpads of each rat with alcohol solution on cotton, and then randomly divide them into normal group, negative foot group, and test foot group, 10 feet (left and right feet) in each group, 5 rats in the normal group, and 10 rats in each of the other groups.

[0092] Test method: 1) normal group subcutaneous injection of equal volume of water for injection in the middle of the abdomen, when dosing, use a cotton swab to apply purified water to the plantar of the left and right hind paws; the negative foot group and the test foot group are the same group of rats, if the negative foot group is randomly defined as the left hind paw, the test group is the right hind paw, the negative foot group and the test foot group are randomly divided into feet, in each sample number, the negative foot group of 10 feet should be 5 left hind paws and 5 right hind paws, and the test foot group of 10 feet should also be 5 left hind paws and 5 right hind paws, each group has 10 feet; after subcutaneous injection of pilocarpine nitrate 1.0 mg / kg in the same position of the rats, the negative foot group was given purified water with a cotton swab when dosing; the test foot group was given different numbered test sample liquid preparations with a cotton swab when dosing; 2) after injection of water for injection in the normal group and pilocarpine nitrate in the other groups, immediately put the rats into wire cages, one rat per cage, fixed in a supine position, the left and right hind paws of each rat were fixed separately outside the cage, the normal group was given purified water with a cotton swab to the plantar of each left and right hind paw, the negative foot group was given purified water with a cotton swab to the plantar of each left and right hind paw, and the test foot group was given different numbered test sample liquid preparations with a cotton swab to the plantar of each left and right hind paw, the surface should be fully moistened when applying the plantar, and then dried naturally, then 20 mg / ml iodine in ethanol solution was applied to the plantar of each hind paw, dried, and then 0.5 g / ml soluble starch castor oil solution was applied to the plantar of each hind paw to form a thin starch coating on the surface of the plantar, timing from the injection of pilocarpine nitrate, after 60 minutes, the plantar of each hind paw was counted under a magnifying glass for dark purple spots, i.e. sweating points.

[0093] The test results are shown in Table 1.

[0094] Table 1

[0095] Group Sweat point number Normal group 26 Liquid preparation 1 group Negative foot: 176, test foot: 0 Liquid preparation 2 group Negative foot: 165, test foot: 9 Liquid preparation 3 group Negative foot: 160, test foot: 13 Liquid preparation 4 group Negative foot: 171, test foot: 108 Liquid preparation 5 group Negative foot: 154, test foot: 139 Liquid preparation 6 group Negative foot: 166, test foot: 117 Liquid preparation 7 group Negative foot: 182, test foot: 96

[0096] From Table 1, it can be seen that:

[0097] 1) Compared with the traditional Chinese medicine composition provided by the normal group and Comparative Examples 1-4, the traditional Chinese medicine composition provided by the examples can effectively prevent the sweating phenomenon induced by pilocarpine nitrate, and has fewer sweating points than the normal rats, and the traditional Chinese medicine composition provided by Example 1 can completely inhibit sweating, with the best effect;

[0098] 2) From the test results of Example 1, Comparative Example 1 and Comparative Example 2, it can be seen that the use of Gynura japonica alone can inhibit the sweating phenomenon induced by pilocarpine nitrate to a certain extent, and the use of Sedum lineare alone does not have a significant antiperspirant effect; however, when Gynura japonica and Sedum lineare are used together, the antiperspirant effect is much greater than that of Gynura japonica or Sedum lineare alone, indicating that the two have a significant positive synergistic effect;

[0099] 3) Through the test results of Comparative Example 1 and Comparative Example 3, it can be known that when the amount of Sedum lineare is relatively excessive, Sedum lineare and Herba Gynura securi show a certain degree of antagonism, and the antiperspirant effect of Herba Gynura securi is weakened;

[0100] 4) Through the test results of Example 1 and Comparative Example 4, it can be known that the treatment effect of the traditional Chinese medicine composition obtained by the reduced pressure reflux extraction under specific conditions on hyperhidrosis is more significant.

[0101] In conclusion, the present application provides a traditional Chinese medicine composition for treating hyperhidrosis and a preparation method thereof, wherein Herba Gynura securi and Sedum lineare are used in a proper proportion, and the two components synergize with each other to prepare a traditional Chinese medicine composition for treating hyperhidrosis, which has a significant treatment effect and simple compatibility, and provides a new means for treating hyperhidrosis and has practical application value.

[0102] The above description is merely a specific implementation of the present application, which enables those skilled in the art to understand or implement the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to these embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A traditional Chinese medicine composition for treating hyperhidrosis, characterized in that, The traditional Chinese medicine composition for treating hyperhidrosis, by weight, is made from the following raw materials: 54-78 parts of *Chrysanthemum indicum* and 15-28 parts of *Sedum aizoon*; The preparation method of the traditional Chinese medicine composition for treating hyperhidrosis includes the following steps: The two herbs, *Gynostemma pentaphyllum* and *Sedum aizoon*, were crushed and mixed to obtain a mixture. The mixture was added to water and subjected to a first vacuum reflux extraction for 1 to 3 hours at a pressure of 4 to 8 kPa and a temperature of 45 to 50°C, followed by filtration to obtain the first extract and the residue. Add water of the same volume as the first extract to the residue, and then perform a second vacuum reflux extraction for 1-3 hours at a pressure of 15-20 kPa and a temperature of 61-65°C. After filtration, the second extract is obtained. The first extract and the second extract were combined, concentrated, and then dried to obtain the traditional Chinese medicine composition.

2. The traditional Chinese medicine composition for treating hyperhidrosis according to claim 1, characterized in that, The traditional Chinese medicine composition for treating hyperhidrosis, by weight, is made from the following raw materials: 67.5 parts of *Gynostemma pentaphyllum* and 22 parts of *Sedum sarmentosum*.

3. The traditional Chinese medicine composition for treating hyperhidrosis according to claim 1, characterized in that, The operating parameters for the first depressurization reflux extraction include: pressure of 6 kPa and temperature of 47°C.

4. The traditional Chinese medicine composition for treating hyperhidrosis according to claim 1, characterized in that, The operating parameters for the second depressurization reflux extraction include: pressure of 18 kPa and temperature of 63°C.

5. The traditional Chinese medicine composition for treating hyperhidrosis according to claim 1, characterized in that, The initial weight-to-volume ratio of the mixture to the water, expressed in g / ml, is 1:(10~20).

6. The use of any one of the traditional Chinese medicine compositions for treating hyperhidrosis according to claims 1 to 5 in the preparation of a drug for treating hyperhidrosis.

7. A liquid preparation for treating hyperhidrosis, characterized in that, The active ingredient of the liquid preparation is the traditional Chinese medicine composition for treating hyperhidrosis as described in any one of claims 1 to 5.

8. The liquid preparation for treating hyperhidrosis according to claim 7, characterized in that, The liquid formulation for treating hyperhidrosis comprises the following components by weight percentage: The traditional Chinese medicine composition for treating hyperhidrosis according to any one of claims 1 to 5 comprises 5-45% ethanol, 10-35% water, and the remainder being water.