A traditional Chinese medicine preparation for use after colorectal cancer surgery

Abstract

This invention relates to the field of traditional Chinese medicine (TCM) technology and discloses a TCM preparation for postoperative treatment of colorectal cancer. The preparation is made from raw materials including Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Glycyrrhiza uralensis (processed), Berberine, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum, and Pogostemon cablin. This TCM preparation is of significant importance in the medical field, focusing on the conditioning of the physical condition of patients after colorectal cancer surgery. The TCM preparation disclosed in this invention features a unique combination of raw materials, encompassing multiple TCM herbs with different efficacies and synergistic effects. Furthermore, the invention employs a carefully designed ratio of TCM components to achieve significant synergistic effects among the various raw materials. This TCM preparation can effectively condition the physical condition of patients after colorectal cancer surgery, significantly reduce the adverse effects of chemotherapy drugs, protect liver and kidney function, and greatly reduce the occurrence of chemotherapy side effects, providing strong support for patient recovery.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and more specifically, to a traditional Chinese medicine preparation for use after colorectal cancer surgery. Background Technology

[0002] Chemotherapy, a key treatment for colorectal cancer, has a significant killing effect on cancer cells, but it can also cause a series of adverse reactions, including nausea, vomiting, and fatigue. These adverse reactions undoubtedly place a heavy physical and psychological burden on patients. Therefore, developing products that reduce the side effects of chemotherapy and improve treatment efficacy is particularly important.

[0003] In recent years, with the continuous advancement of science and technology, people have been constantly exploring ways to alleviate the side effects of chemotherapy. Traditional Chinese medicine (TCM), as a traditional medical system, has long been exploring new ways to combine with chemotherapy. Many studies have shown that some active ingredients in TCM can reduce the side effects of chemotherapy and enhance its efficacy. To better meet clinical needs, many research institutions and enterprises are dedicated to developing chemotherapy adjuvant products based on TCM theories.

[0004] Colorectal cancer is a serious health threat, primarily affecting the colon or rectum. Therefore, developing traditional Chinese medicine preparations for post-operative colorectal cancer surgery is of great significance for restoring patients' physical function and preventing recurrence. Summary of the Invention

[0005] Colorectal cancer is a common malignant tumor of the digestive tract. After colorectal cancer surgery, patients often experience a series of adverse reactions, such as pain, nausea, vomiting, and diarrhea. These symptoms not only affect the patient's quality of life but may also negatively impact recovery. Therefore, finding effective nursing measures to alleviate these adverse reactions is crucial for postoperative care of colorectal cancer patients. In view of this, this invention proposes a traditional Chinese medicine preparation for postoperative colorectal cancer surgery, aiming to assist chemotherapy, improve treatment efficacy, and reduce patient suffering.

[0006] This invention proposes a traditional Chinese medicine preparation for use after colorectal cancer surgery, characterized in that it is made from the following raw materials:

[0007] Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Glycyrrhiza uralensis (processed), Berberine, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum, and Pogostemon cablin.

[0008] Preferably, the weight ratio of Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Glycyrrhiza uralensis (processed), Berberine, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum, and Pogostemon cablin is 20-30:10-20:5-15:5-15:20-30:5-15:5-15:10-20:10-20:10-20:5-15:5-15.

[0009] More preferably, the weight ratio of Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Glycyrrhiza uralensis (processed), Berberine, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum and Pogostemon cablin is 25:15:10:10:25:10:10:15:15:15:10:10.

[0010] Preferably, the traditional Chinese medicine preparation further includes excipients, which are pharmaceutically acceptable carriers or excipients.

[0011] Preferably, the excipients include one or more of fillers, disintegrants, binders, and lubricants.

[0012] Preferably, the filler is starch, lactose, glucose or microcrystalline cellulose;

[0013] The disintegrant is sodium carboxymethyl starch, crospovidone, or low-substituted hydroxypropyl cellulose;

[0014] The adhesive is povidone, gelatin, or gum arabic.

[0015] The lubricant is magnesium stearate, talc, or polyethylene glycol.

[0016] Preferably, the dosage form of the traditional Chinese medicine preparation is tablets, capsules, granules or pills.

[0017] Understandably, even with the rapid development of modern medicine, traditional Chinese medicine preparations still play an irreplaceable role in disease treatment due to their unique efficacy and relatively few side effects. This invention discloses a traditional Chinese medicine preparation for postoperative rehabilitation of colorectal cancer. Its unique combination of raw materials includes Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Glycyrrhiza uralensis (processed), Berberine, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum, and Pogostemon cablin, among other Chinese medicinal herbs. This combination of raw materials not only embodies the essence of traditional Chinese medicine theory but has also been scientifically validated through modern medical research.

[0018] Atractylodes macrocephala, an important ingredient in traditional Chinese medicine preparations, has the effects of strengthening the spleen and stomach, replenishing qi and consolidating the exterior. During the recovery process after colorectal cancer surgery, Atractylodes macrocephala helps improve the patient's digestive function, enhance physical strength, and provide strong support for recovery. Cynanchum paniculatum, with its heat-clearing, detoxifying, blood-cooling, and hemostatic effects, has a positive effect on alleviating postoperative inflammatory reactions and controlling the risk of infection.

[0019] Kochia scoparia and Arisaema heterophyllum are commonly used in traditional Chinese medicine preparations to reduce swelling, dissipate nodules, and relieve pain. After colorectal cancer surgery, patients often face pain and swelling; the addition of these two herbs can effectively alleviate these symptoms and improve their quality of life. Coix seed, a common traditional Chinese medicine, has the effects of strengthening the spleen, promoting diuresis, clearing heat, and detoxifying, playing an indispensable role in improving the overall health of patients.

[0020] The addition of prepared licorice root, berberine, and acorus tatarinowii further enriches the efficacy of traditional Chinese medicine preparations. Prepared licorice root can harmonize the properties of other herbs and enhance their effects; berberine has the effects of clearing heat and detoxifying, drying dampness and stopping dysentery, and is of positive significance for preventing postoperative infection and promoting wound healing; acorus tatarinowii, with its effects of opening the orifices and refreshing the mind, resolving dampness and harmonizing the stomach, helps to improve the patient's mental state and promote appetite.

[0021] Medicinal herbs such as Magnolia officinalis, Amomum villosum, and Amomum villosum have the effects of warming the middle jiao (spleen and stomach), dispelling cold, promoting qi circulation, and relieving pain. During the postoperative recovery stage of colorectal cancer surgery, the application of these herbs helps to regulate the patient's qi and blood circulation, alleviate postoperative pain, and promote physical recovery. Patchouli, as a commonly used traditional Chinese medicine, has the effects of aromatically resolving dampness and relieving nausea, and has a significant effect on improving the patient's gastrointestinal function and alleviating symptoms such as nausea and vomiting.

[0022] In summary, the traditional Chinese medicine preparation disclosed in this invention has a unique combination of raw materials, encompassing a variety of Chinese medicinal herbs with different effects. The synergistic effect of these herbs makes this traditional Chinese medicine preparation a promising candidate for postoperative rehabilitation treatment of colorectal cancer.

[0023] This invention also proposes a method for preparing any of the traditional Chinese medicine preparations described above for use after colorectal cancer surgery, comprising the following steps:

[0024] (1) After roasting berberine and roasted licorice, the Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum, Pogostemon cablin and roasted licorice and berberine are mixed evenly to obtain a mixture;

[0025] (2) The mixture obtained in step (1) is crushed and sieved to obtain medicinal powder;

[0026] (3) The powder and excipients are mixed evenly, and then granulated, dried and sized to obtain granules;

[0027] (4) Compress the granules obtained in step (3) into tablets, capsules, granules or pills to obtain the traditional Chinese medicine preparation for colorectal cancer surgery.

[0028] Preferably, the step of roasting the berberine and roasted licorice includes:

[0029] Place berberine and roasted licorice separately in a roasting device, control the roasting temperature at 150-200℃, and roast for 10-30 minutes until the surface of berberine and roasted licorice turns slightly yellow and has a fragrance. Remove and let cool for later use.

[0030] Preferably, in step (1), the Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum, Pogostemon cablin, and roasted licorice root and berberine are mixed evenly and then subjected to a mixing process. The mixing process includes:

[0031] Place the mixed raw materials in a mixer and mix at a speed of 500-1000 revolutions per minute for 10-30 minutes until the raw materials are evenly mixed.

[0032] Preferably, in step (2), the particle size of the pulverized material is 80-120 mesh; in step (3), the particle size of the granulated material is 10-20 mesh.

[0033] Preferably, in step (3), after the pharmaceutical powder and excipients are mixed evenly, wet granulation is performed. The wet granulation process includes the following steps:

[0034] After the powdered medicine and excipients are mixed evenly, water is added to form a soft mass, which is then granulated using a granulator to obtain wet granules. These granules are then dried and sized to obtain the final granules.

[0035] It is understood that this invention also proposes a method for preparing a traditional Chinese medicine preparation for use after colorectal cancer surgery. This method, based on traditional Chinese medicine and combined with modern pharmaceutical technology, aims to provide patients with a safe and effective treatment option.

[0036] First, this invention selects a series of Chinese medicinal herbs with medicinal value, including berberine, prepared licorice root, atractylodes macrocephala, cynanchum paniculatum, kochia scoparia, arisaema heterophyllum, coix seed, acorus tatarinowii, magnolia officinalis, cardamom, amomum villosum, and agastache rugosa. These herbs have a long history and wide application in traditional Chinese medicine, and are believed to have the effects of clearing heat and detoxifying, strengthening the spleen and stomach, and promoting diuresis and pus drainage, which are of great significance for the recovery after colorectal cancer surgery.

[0037] In the preparation process, berberine and prepared licorice are first roasted. Roasting is a traditional Chinese medicine processing method that can alter the properties and flavor of medicinal materials and enhance their efficacy. In this invention, berberine and prepared licorice are placed in a roasting device, with the roasting temperature controlled at 150-200℃ and the roasting time controlled at 10-30 minutes, until the surface of the medicinal materials turns slightly yellow and develops a fragrance. This roasting treatment allows the active ingredients in the medicinal materials to dissolve and be released more easily, thus improving the efficacy.

[0038] Next, the roasted berberine and roasted licorice are mixed evenly with the other medicinal materials. During the mixing process, the raw materials are placed in a mixer and mixed at a speed of 500-1000 rpm for 10-30 minutes to ensure thorough and uniform mixing. This mixing process helps improve the stability of the formulation and the uniformity of its efficacy.

[0039] Subsequently, the mixed powder is pulverized and sieved to obtain powder with a suitable particle size. In this invention, the particle size is 80-120 mesh, which ensures that the powder can be better shaped and dried in the subsequent granulation process.

[0040] Next, the pharmaceutical powder and excipients are mixed evenly and then subjected to wet granulation. Wet granulation is a commonly used pharmaceutical process that mixes pharmaceutical powder and excipients to form wet granules, which are then dried and sized to obtain the final granules. In the wet granulation process, this invention mixes the pharmaceutical powder and excipients evenly, adds an appropriate amount of water to form a soft mass, and then granulates it using a granulator. The resulting wet granules are dried and sized to obtain granules of suitable size.

[0041] Finally, the obtained granules are processed through tableting, capsule encapsulation, granulation, or pill making to obtain the final traditional Chinese medicine preparation for use after colorectal cancer surgery. This preparation form is convenient for patients to take and can maintain the effective components and efficacy of the medicinal materials.

[0042] In summary, this invention presents a method for preparing a traditional Chinese medicine preparation for use after colorectal cancer surgery. This method combines traditional Chinese medicine with modern pharmaceutical technology, selecting medicinal herbs with medicinal value and preparing a safe and effective preparation through steps such as roasting, mixing, pulverizing, and granulation. This preparation is of great significance for postoperative recovery after colorectal cancer surgery and deserves further research and promotion.

[0043] The present invention also proposes the application of any of the traditional Chinese medicine preparations described above for use after colorectal cancer surgery in the preparation of postoperative drugs for colorectal cancer.

[0044] Preferably, the drug includes a chemotherapy drug, a targeted drug, or an immunotherapy drug.

[0045] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0046] 1. The traditional Chinese medicine preparation proposed in this invention has a unique formulation, with Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Glycyrrhiza uralensis (processed), Berberine, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum, and Pogostemon cablin as the main raw materials. Through careful formulation, it has a synergistic effect and can effectively regulate the physical condition after colorectal cancer surgery, thereby improving the patient's quality of life.

[0047] 2. The present invention optimizes the proportion of raw materials, and by precisely controlling the weight ratio of each raw material, the efficacy of the traditional Chinese medicine preparation is more prominent and the therapeutic effect is more obvious.

[0048] 3. This invention also takes into account the dosage form of traditional Chinese medicine preparations, providing a variety of dosage forms such as tablets, capsules, granules or pills, which are convenient for patients to use and also meet different medication needs.

[0049] 4. The present invention also describes the preparation method in detail, including steps such as roasting, mixing, and wet granulation, which ensures the quality stability of the traditional Chinese medicine preparation and improves the preparation efficiency.

[0050] 5. This invention also proposes the application of traditional Chinese medicine preparations in the preparation of postoperative drugs for colorectal cancer. These preparations can be used in combination with chemotherapy drugs, targeted drugs, or immunotherapeutic drugs to improve the therapeutic effect, reduce side effects, and play an important role in promoting postoperative recovery for colorectal cancer.

[0051] In summary, the traditional Chinese medicine preparations, their preparation methods, and applications proposed in this invention for colorectal cancer surgery have unique formulations, precise proportions, diverse dosage forms, standardized preparation processes, and broad application prospects. They play an important role in promoting postoperative rehabilitation for colorectal cancer patients and have high practical value and broad application prospects. Detailed Implementation

[0052] Exemplary embodiments of this disclosure will now be described in more detail. While exemplary embodiments of this disclosure are shown below, it should be understood that this disclosure may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided to enable a more thorough understanding of this disclosure and to fully convey its scope to those skilled in the art. It should be noted that, unless otherwise specified, embodiments and features described herein can be combined with each other. The invention will now be described in detail with reference to embodiments.

[0053] Example 1: Preparation of a traditional Chinese medicine preparation for colorectal cancer surgery

[0054] The following raw materials were selected according to a weight ratio of 25:15:10:10:25:10:10:15:15:15:10:10: Atractylodes macrocephala, Cynanchum paniculatum, Kochia scoparia, Arisaema heterophyllum, Coix lacryma-jobi, Glycyrrhiza uralensis (processed), Berberine, Acorus tatarinowii, Magnolia officinalis, Amomum villosum, Amomum villosum, and Pogostemon cablin.

[0055] Berberine and roasted licorice were placed in a roasting device, and the roasting temperature was controlled at 180℃ for 20 minutes, until the surface of berberine and roasted licorice turned slightly yellow and had a fragrance. They were then removed and cooled for later use. The other raw materials were mixed evenly with the roasted licorice and berberine. The mixture was then placed in a mixer and mixed at a speed of 800 rpm for 20 minutes, until the raw materials were evenly mixed.

[0056] The mixed active pharmaceutical ingredient is pulverized to a particle size of 100 mesh and then sieved to obtain a powder. An appropriate amount of pharmaceutically acceptable carrier or excipient, including starch as a filler, sodium carboxymethyl starch as a disintegrant, povidone as a binder, and magnesium stearate as a lubricant, is mixed evenly with the powder and then subjected to wet granulation.

[0057] After the powdered medicine and excipients are mixed evenly, an appropriate amount of water is added to form a soft material, which is then granulated by a granulator to obtain wet granules. After drying and granulation, granules with a particle size of 15 mesh are obtained.

[0058] The obtained granules are compressed into tablets to obtain a traditional Chinese medicine preparation for use after colorectal cancer surgery.

[0059] Example 2: Preparation of a traditional Chinese medicine preparation for colorectal cancer surgery

[0060] Similar to Example 1, but the weight ratio was adjusted to 20:20:5:15:30:5:15:10:20:10:5:15. During the roasting process, berberine and licorice were roasted at 150°C for 10 minutes. When mixing the raw materials, the mixer speed was 500 rpm for 10 minutes. The particle size was 80 mesh. During wet granulation, lactose was added as a filler in addition to starch. The final granules were then encapsulated to form capsules.

[0061] Example 3: Preparation of a traditional Chinese medicine preparation for colorectal cancer surgery

[0062] Similar to Example 1, but the weight ratio was adjusted to 30:10:15:5:20:15:5:20:10:20:15:5. During the roasting process, berberine and licorice were roasted at 200°C for 30 minutes. When mixing the raw materials, the mixer speed was 1000 rpm for 30 minutes. The particle size was 120 mesh. During wet granulation, in addition to sodium carboxymethyl starch as a disintegrant, crospovidone was also added. The final granules were then processed into pills.

[0063] Experiment 1: Toxicity test was conducted on the traditional Chinese medicine preparations obtained in Examples 1-3.

[0064] Experimental animals were taken and divided into groups and given the traditional Chinese medicine preparations prepared in Examples 1, 2, and 3. The animals' survival status, weight changes, organ function, and other indicators were observed to assess the toxicity of the traditional Chinese medicine preparations. Observation and testing revealed that the traditional Chinese medicine preparations prepared in Examples 1, 2, and 3 had no toxic effects on the experimental animals; all indicators were normal, and no obvious side effects were observed. Therefore, these traditional Chinese medicine preparations can be considered to have a certain degree of safety and can be used as adjuvant therapy after colorectal cancer surgery.

[0065] Experiment 2: Animal experiments were conducted on the traditional Chinese medicine preparations obtained in Examples 1-3.

[0066] To verify the efficacy of the traditional Chinese medicine preparations obtained in Examples 1-3 on postoperative colorectal cancer, animal experiments were conducted in this invention.

[0067] Fifty rats of similar weight were selected for the experiment and divided into 5 groups of 10 rats each. Group 1 was the control group, which received no treatment; Groups 2-4 were the treatment groups for the traditional Chinese medicine preparations prepared in Examples 1-3, and each group of rats was given the corresponding preparation by gavage daily; Group 5 was the positive control group, which was given commercially available postoperative treatment drugs for colorectal cancer.

[0068] The experiment lasted for 30 days, during which the weight, appetite, mental state and other indicators of the rats in each group were recorded. After the experiment, the rats were dissected to observe the recovery of the large intestine tissue.

[0069] The experimental results showed that rats in groups 2-4 recovered their body weight more quickly, and their appetite and mental state were better than those in the control group and the positive control group. Autopsy results showed that the large intestine tissue of rats in groups 2-4 recovered better, and the degree of inflammation was milder.

[0070] Based on the comprehensive experimental results, it can be concluded that the traditional Chinese medicine preparations prepared in Examples 1-3 have a certain promoting effect on postoperative recovery of colorectal cancer, and the effect is comparable to that of commonly used drugs on the market.

[0071] Experimental Example 3: Application of Traditional Chinese Medicine Preparations Combined with Chemotherapy Drugs in Postoperative Treatment of Colorectal Cancer

[0072] With the continuous development of medical technology, the treatment methods for colorectal cancer are also constantly being improved and perfected. Chemotherapy, as one of the important means of treating colorectal cancer, can effectively kill cancer cells, but it is also accompanied by a series of side effects, such as nausea, vomiting, and fatigue, causing great suffering to patients. In order to reduce the side effects of chemotherapy and improve the treatment effect, this invention conducted this experiment, combining the traditional Chinese medicine preparation prepared in Example 1 for postoperative colorectal cancer with chemotherapy drugs to observe its efficacy.

[0073] This trial selected 50 postoperative colorectal cancer patients, aged 40-70 years, all of whom were candidates for chemotherapy. The patients were randomly divided into two groups: a control group and an experimental group, with 25 patients in each group. The control group received conventional chemotherapy, while the experimental group received chemotherapy plus three tablets of traditional Chinese medicine three times daily.

[0074] After one month of treatment, the patients' recovery was observed and evaluated. The results showed that the patients in the experimental group experienced significant improvement in their physical condition and a reduction in the side effects of chemotherapy. Specifically, the experimental group showed a significant reduction in symptoms such as nausea and vomiting, and improved appetite and energy. Simultaneously, the experimental group's liver and kidney function indicators were significantly better than the control group, indicating that the addition of traditional Chinese medicine preparations can effectively protect the patients' liver and kidney function and reduce the damage caused by chemotherapy drugs.

[0075] The results of this experiment indicate that traditional Chinese medicine (TCM) preparations can assist chemotherapy, improve treatment efficacy, and alleviate patient suffering. This is mainly due to the synergistic effect of various effective components in the TCM preparations, such as those that clear heat and detoxify, promote blood circulation and remove blood stasis, and nourish qi and yin. These components can regulate the patient's physical condition, enhance immunity, and improve the efficacy of chemotherapy drugs. Simultaneously, the addition of TCM preparations can also reduce the damage of chemotherapy drugs to the body, protect the patient's liver and kidney function, and reduce the occurrence of chemotherapy side effects. The combination of TCM preparations and chemotherapy drugs has significant advantages in the postoperative treatment of colorectal cancer, assisting chemotherapy, improving treatment efficacy, and alleviating patient suffering. Therefore, in clinical practice, for eligible postoperative colorectal cancer patients, the treatment regimen of the TCM preparations combined with chemotherapy drugs of this invention can be considered to improve patients' quality of life and prognosis.

[0076] In summary, this invention not only provides a traditional Chinese medicine preparation for postoperative treatment of colorectal cancer, but also proposes its application in the preparation of postoperative medications for colorectal cancer. This innovative application undoubtedly opens up new avenues for postoperative treatment of colorectal cancer, providing patients with more treatment options.

[0077] Firstly, as a product of the integration of traditional and modern medicine, this traditional Chinese medicine preparation fully leverages the advantages of traditional Chinese medicine in regulating the body's constitution and reducing the side effects of chemotherapy. During the postoperative recovery period, patients often face problems such as physical weakness and decreased immunity, and this traditional Chinese medicine preparation can provide effective support in these areas. It can not only help patients quickly regain their strength but also, to some extent, reduce the side effects of chemotherapy drugs, such as nausea, vomiting, and fatigue, thereby improving the patient's quality of life.

[0078] Next, the preferred drugs for the application of traditional Chinese medicine preparations in the preparation of postoperative drugs for colorectal cancer include chemotherapy drugs, targeted drugs, or immunotherapeutic drugs.

[0079] Chemotherapy is currently one of the main treatments after colorectal cancer surgery. It can kill residual cancer cells and prevent recurrence. However, chemotherapy drugs also have certain side effects, such as bone marrow suppression and liver and kidney damage. The addition of traditional Chinese medicine preparations can, to some extent, alleviate these side effects and improve the efficacy of chemotherapy.

[0080] Targeted therapy is a novel treatment approach that has emerged in recent years. It can precisely target cancer cells while minimizing damage to normal cells. However, targeted drugs also face the challenge of drug resistance. The incorporation of traditional Chinese medicine preparations can, to some extent, delay the development of drug resistance, thereby improving the therapeutic efficacy of targeted drugs.

[0081] Immunotherapy drugs work by activating the patient's own immune system to kill cancer cells, showing high therapeutic efficacy. However, immunotherapy drugs also have certain side effects, such as immune-related inflammation. The addition of traditional Chinese medicine preparations can, to some extent, alleviate these side effects and improve the safety of immunotherapy drugs.

[0082] In conclusion, the application of the traditional Chinese medicine preparation proposed in this invention in postoperative medication for colorectal cancer not only provides patients with more treatment options but also reduces drug side effects and improves treatment efficacy to a certain extent. This innovative application undoubtedly brings new hope to the postoperative treatment of colorectal cancer.

[0083] The above description of the disclosed embodiments enables those skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A traditional Chinese medicine preparation for postoperative colorectal cancer, characterized in that, Prepared from the following raw materials: Atractylodes, Cyperus, Semen Vaccariae, Dioscorea, Coix, Radix Glycyrrhizae, Berberine, Acorus, Zedoary, Alpinia, Amomum and Agastache; the weight ratio of Atractylodes, Cyperus, Semen Vaccariae, Dioscorea, Coix, Radix Glycyrrhizae, Berberine, Acorus, Zedoary, Alpinia, Amomum and Agastache is 20-30:10-20:5-15:5-15:20-30:5-15:5-15:10-20:10-20:10-20:5-15:5-15.

2. The traditional Chinese medicine preparation for postoperative colorectal cancer according to claim 1, characterized in that, The traditional Chinese medicine preparation also includes an auxiliary material, which is a pharmaceutically acceptable carrier or excipient. 3.The traditional Chinese medicine preparation for postoperative colorectal cancer of claim 2, characterized in that, The auxiliary material includes one or more of a filler, a disintegrant, a binder, and a lubricant.

4. The traditional Chinese medicine preparation for postoperative colorectal cancer according to any one of claims 1-3, characterized in that, The dosage form of the traditional Chinese medicine preparation is a tablet, a capsule, a granule, or a pill.

5. A method for preparing the traditional Chinese medicine preparation for postoperative large intestinal cancer according to any one of claims 1-4, characterized in that, The method comprises the following steps: (1) After baking and roasting the Berberine and Radix Glycyrrhizae respectively, the Atractylodes, Cyperus, Semen Vaccariae, Dioscorea, Coix, Acorus, Zedoary, Alpinia, Amomum, Agastache, and the baked and roasted Radix Glycyrrhizae and Berberine are mixed uniformly to obtain a mixture; (2) The mixture obtained in step (1) is crushed, sieved, and a medicinal powder is obtained; (3) The medicinal powder is mixed uniformly with an auxiliary material, granulated, dried, and granulated to obtain granules; (4) The granules obtained in step (3) are tabletted, encapsulated, granulated, or pillated to obtain the traditional Chinese medicine preparation for postoperative colorectal cancer.

6. The production method according to claim 5, wherein In step (2), the particle size of the crushed granules is 80-120 mesh; in step (3), the particle size of the granulated granules is 10-20 mesh.

7. Use of the traditional Chinese medicine preparation for postoperative colorectal cancer according to any one of claims 1-4 in the preparation of a postoperative colorectal cancer drug.