Capsule for auxiliary treatment of nephrotic syndrome and preparation method thereof

Abstract

The invention provides a capsule for assisting in treating nephrotic syndrome and a preparation method thereof. The active components of the capsule include the following raw materials in parts by weight: 40-60 parts of silkworm pupa powder, 35-55 parts of achyranthes bidentata powder, 15-22 parts of fermented cordyceps powder, 14-25 parts of hibiscus pollen, 5-11 parts and 10-15 parts of yam powder, 5-8 parts of malus chinensis root, 5-8 parts of tuckahoe, 3-7 parts of rosa laevigata fruit, 2-6 parts of wolfberry and 3-8 parts of dodder seed. The active components of the drugs of each component are respectively extracted according to the principle of monarch, minister, assistant and envoy compatibility, so that the prescription of the invention has the effects of protecting the kidney and reducing urine protein through scientific deployment of the drugs, is helpful to reduce blood lipid level and alleviate the dyslipidemia symptoms of nephrotic syndrome.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a capsule for assisting in the treatment of nephrotic syndrome and a preparation method thereof. Background Art

[0002] Nephrotic syndrome (NS) is a clinical syndrome composed of a group of glomerular diseases with similar clinical manifestations, different causes and pathological changes. It is often manifested by typical symptoms such as massive proteinuria, severe edema, hyperlipidemia and hypoproteinemia, which can cause renal function damage, bacterial infection, protein and metabolic disorders, etc. Nephrotic syndrome is a glomerular disease caused by various causes, with increased permeability of the glomerular basement membrane and decreased glomerular filtration rate as the main characteristics. This disease has multiple causes, including secondary factors such as infection, drugs, toxins and allergies, tumors, systemic lupus erythematosus, Henoch-Schonlein purpura amyloidosis and diabetes, as well as primary factors such as primary glomerulonephropathy, acute and chronic glomerulonephritis and rapidly progressive nephritis.

[0003] The treatment of nephrotic syndrome requires a combination of multiple methods, including drug therapy, dietary adjustments, lifestyle changes, etc. In terms of drug therapy, glucocorticoids and immunosuppressants are currently the main treatments used. In addition, the diet and lifestyle of patients with nephrotic syndrome also need to be adjusted accordingly, such as a low-salt, low-fat, low-sugar diet, avoiding excessive fatigue, etc. In terms of drug therapy, Western medicine treatment also needs to consider drug side effects, drug resistance, and infusion reactions. Long-term treatment has a greater negative impact on patients, while traditional Chinese medicine treatment needs to consider the compatibility principles of drugs, and different drugs need to be selected for different syndromes. The current drug combination fails to effectively treat nephrotic syndrome. Summary of the invention

[0004] In view of this, the present invention provides a capsule for assisting in the treatment of nephrotic syndrome and a preparation method thereof to solve the above problems.

[0005] The technical scheme of the present invention is implemented as follows: a capsule for auxiliary treatment of nephrotic syndrome: its active components include the following raw materials in parts by weight: 40-60 parts of silkworm pupa powder, 35-55 parts of Achyranthes bidentata powder, 15-22 parts of fermented Cordyceps sinensis powder, 14-25 parts of Hibiscus truncatum pollen, 5-11 parts, 10-15 parts of yam powder, 5-8 parts of Begonia root, 5-8 parts of Poria cocos, 3-7 parts of Rosa laevigata, 2-6 parts of Lycium barbarum, and 3-8 parts of Cuscuta australis.

[0006] Furthermore, a capsule for auxiliary treatment of nephrotic syndrome: its active group includes the following raw materials in parts by weight: 50 parts of silkworm pupa powder, 45 parts of Achyranthes bidentata powder, 18 parts of fermented Cordyceps sinensis powder, 20 parts of Hibiscus sibiricum pollen, 8 parts, 12 parts of yam powder, 6 parts of Begonia root, 7 parts of Poria cocos, 5 parts of Rosa laevigata, 4 parts of Lycium barbarum, and 5 parts of Cuscuta australis.

[0007] Furthermore, a capsule for auxiliary treatment of nephrotic syndrome, the active group of which also includes the following raw materials in parts by weight: 15-25 parts of Tripterygium wilfordii, 3-5 parts of Partridge Tea, and 1-5 parts of Citrus aurantium.

[0008] Furthermore, a capsule for auxiliary treatment of nephrotic syndrome, the active group of which also includes the following raw materials in parts by weight: 20 parts of Tripterygium wilfordii, 4 parts of Partridge Tea, and 3 parts of Citrus aurantium.

[0009] Furthermore, a method for preparing a capsule for assisting the treatment of nephrotic syndrome comprises the following raw materials in parts by weight:

[0010] Step 1: according to the above formula, silkworm pupa powder, Achyranthes bidentata powder, fermented Cordyceps sinensis powder, Hibiscus truncatum pollen and Tripterygium wilfordii are mixed and stirred, ethanol is added for extraction to obtain an extract, the extract is concentrated for the first time to obtain a concentrated solution I, and then the concentrated solution I is filtered, the filtrate is extracted with chloroform, the chloroform layer is collected for the second concentration to obtain a concentrated solution II, the concentrated solution is passed through a silica gel column, eluted, and the eluate is collected for the third concentration to obtain a concentrated solution III for standby use;

[0011] Step 2: Mix yam powder, Malus opposita root and Citrus aurantium, add 2-5 times the mass of water of the mixture, stir the mixture evenly, heat at 100-120° C. for 20-30 min, remove impurities, filter, and dry to obtain a mixed extract;

[0012] Step 3: Mix and stir the above concentrated solution III and the mixed extract, Poria cocos, Rosa laevigata, Lycium barbarum, Cuscuta australis, and Partridge tea at a rate of 1500-2000 rpm under ultrasonic action, and then filter and concentrate to obtain a traditional Chinese medicine composition;

[0013] Step 4: Dry and crush the Chinese medicine composition to obtain powder, fill it into hollow capsules, ensure that the filling is uniform and tight, seal it, and package it to obtain a capsule for auxiliary treatment of nephrotic syndrome.

[0014] Furthermore, in step 1, the mass volume ratio of the mixture to ethanol g / mL is 1.5-3.5:20.

[0015] Furthermore, in step 1, the extraction temperature is 50-80° C., and the extraction time is 20-40 min.

[0016] Furthermore, in step 1, the volume ratio v / v of the filtrate to chloroform is 3-8:10.

[0017] Furthermore, in step 1, the extraction temperature is 80-100° C., and the extraction time is 25-35 min.

[0018] Furthermore, in step 3, the ultrasonic power is 18-50W, the frequency is 35-75kHz, and the time is 20-60min.

[0019] Compared with the prior art, the present invention has the following beneficial effects:

[0020] The prescription of the invention follows the compatibility principle of traditional Chinese medicine and the principle of individualized treatment. Silkworm pupa powder, Achyranthes bidentata powder, fermented cordyceps powder and Hibiscus truncatum pollen are mutually monarch medicines and have different effects, and can be used to regulate different symptoms of nephrotic syndrome. Silkworm pupa powder warms the yang and nourishes the kidney, dispels wind and dampness, and can supplement nutrition and improve immunity; Achyranthes bidentata powder promotes blood circulation and unblocks menstruation, and is a diuretic and relieving stranguria; fermented Cordyceps sinensis powder nourishes the lungs and kidneys, relieves cough and reduces phlegm; Hibiscus truncatum pollen clears away heat and detoxifies, and is a diuretic and relieving stranguria; yam powder and Crabapple tree root are used as assistant drugs. Yam powder nourishes the spleen, lungs and kidneys, replenishes qi and nourishes yin, and Crabapple tree root promotes qi and relieves pain, promotes blood circulation and removes blood stasis; Poria and Rosa laevigata are each other's adjuvants, assisting the assistant drugs in strengthening the therapeutic effect. Poria promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind; Rosa laevigata consolidates the essence and reduces urine, and astringes the intestines to stop diarrhea; Lycium barbarum nourishes the liver and kidneys, improves eyesight and moistens the lungs, and Cuscuta chinensis nourishes the liver and kidneys, consolidates the essence and reduces urine. The two are each other's guiding drugs, which can guide the agents of other drugs and play a role in guiding the meridians or harmonizing them.

[0021] The pharmaceutical composition of the present invention has the effects of promoting diuresis and removing dampness, warming yang and strengthening the spleen, promoting qi and promoting diuresis, effectively protecting the kidneys, and reducing the effect of urinary protein. At the same time, the coordinated effect of the drugs also has the function of regulating immunity and regulating glucocorticoids, which can inhibit inflammatory reactions and immune reactions, help lower blood lipid levels, and alleviate the dyslipidemia symptoms of nephrotic syndrome, and can be used to treat kidney-related diseases. DETAILED DESCRIPTION

[0022] In order to better understand the technical content of the present invention, specific embodiments are provided below to further illustrate the present invention.

[0023] Unless otherwise specified, the experimental methods used in the embodiments of the present invention are all conventional methods.

[0024] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.

[0025] 1. Basic information of the main raw materials of the present invention

[0026] Silkworm pupa powder: Nature and flavor: sweet and spicy, warm in nature, and enters the liver and kidney meridians; Functions and indications: Silkworm pupa powder has the effects of warming yang and tonifying the kidney, dispelling wind and dampness, and strengthening the spleen and eliminating accumulation. It can be used to treat kidney yang deficiency, rheumatic arthralgia, infantile malnutrition and other diseases.

[0027] Achyranthes bidentata powder: Nature and flavor: bitter, sweet, sour, neutral. Enters the liver and kidney meridians; Functions and indications: Mainly used to treat low back and knee pain, weak tendons and bones, amenorrhea, liver yang vertigo and other symptoms.

[0028] Fermented Cordyceps Powder: Nature and flavor: sweet, warm, and belongs to the lung and kidney meridians; Functions and indications: It has the effects of replenishing deficiency, replenishing essence and qi, relieving cough and reducing phlegm. It can be used for back pain, cough, asthma, loss of appetite, malnutrition and other symptoms caused by deficiency of both lung and kidney.

[0029] Hibiscus tiliaceus pollen: Nature and flavor: sweet, cold, enters kidney meridian and bladder meridian; Functions: clears away heat and dampness, relieves swelling and promotes urination, clears away heat and detoxifies. It can treat burns, scalds, carbuncle, swollen and toxic, children's mouth sores, lung heat cough and other symptoms.

[0030] Yam powder: Nature and flavor: Yam powder is sweet, neutral, and enters the spleen, lung, and kidney meridians. Functions and indications: Yam powder has the effects of nourishing qi and yin, and tonifying the spleen, lung, and kidney. It is mainly used to treat symptoms such as spleen deficiency, poor appetite, fatigue, loose stools, and diarrhea.

[0031] Begonia root: pungent and warm in nature; functions and indications: promoting qi and relieving pain, promoting blood circulation and removing blood stasis.

[0032] Poria: Nature and flavor: Poria tastes sweet and light, and is neutral in nature. It enters the heart, lung, spleen, and kidney meridians; Functions and indications: It has the effects of promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind.

[0033] Rosa Laevigata: Nature and flavor and meridians: sour, sweet and astringent, it enters the kidney meridian, bladder meridian and large intestine meridian. Functions and indications: consolidates semen and reduces urination, consolidates metrorrhagia and stops leukorrhea, and astringes the intestines and stops diarrhea.

[0034] Lycium barbarum: Nature and flavor: sweet, neutral. Enters the liver and kidney meridians; Functions and indications: nourishes the kidneys, moistens the lungs, nourishes the liver, and improves eyesight. Mainly used to treat liver and kidney yin deficiency, soreness of the waist and knees, dizziness, vertigo, blurred vision and excessive tears.

[0035] Cuscuta: Nature and flavor: Cuscuta tastes pungent and sweet, and is neutral in nature. It enters the liver, kidney, and spleen meridians; Functions and indications: It has the effects of nourishing the liver and kidney, consolidating semen and reducing urine, calming the fetus, improving eyesight, and stopping diarrhea.

[0036] Tripterygium wilfordii: Nature and flavor: pungent, bitter, cool, highly toxic. Enters the heart and liver meridians; Functions and indications: insecticide, anti-inflammatory, detoxification.

[0037] Partridge Tea: Nature and flavor and meridians: neutral and warm; sweet and spicy; enters the lung and spleen meridians; Functions and indications: relieve cough, eliminate accumulation, promote blood circulation and disperse blood stasis, relieve pain, disperse blood stasis, dissipate heat, eliminate phlegm, carbuncle, detoxify, promote blood circulation, clear away heat and detoxify, remove blood stasis and promote new blood, eliminate phlegm and relieve cough.

[0038] Citrus aurantium: Nature and flavor and meridians: bitter, pungent, sour, slightly cold; enters the spleen and stomach meridians; Functions and indications: used for qi stagnation in the chest and flanks, fullness and pain, indigestion, phlegm and fluid retention, and sagging of internal organs. Example 1

[0039] A capsule for assisting in the treatment of nephrotic syndrome, the active components of which include the following raw materials by weight: 40 grams of silkworm pupa powder, 35 grams of Achyranthes bidentata powder, 15 grams of fermented cordyceps powder, 14 grams of Hibiscus truncatum pollen, 5 grams of yam powder, 5 grams of Begonia sibiricum root, 5 grams of Poria cocos, 3 grams of Rosa laevigata fruit, 2 grams of Lycium barbarum, 3 grams of Cuscuta australis, 15 grams of Tripterygium wilfordii, 3 grams of Partridge tea, and 1 gram of Citrus aurantium. Example 2

[0040] A capsule for assisting in the treatment of nephrotic syndrome, the active components of which include the following raw materials by weight: 60 grams of silkworm pupa powder, 55 grams of Achyranthes bidentata powder, 22 grams of fermented cordyceps powder, 25 grams of hibiscus pollen, 11 grams of yam powder, 8 grams of Malus multiflora root, 8 grams of Poria cocos, 7 grams of Rosa laevigata fruit, 6 grams of Lycium barbarum, 8 grams of Cuscuta australis, 25 grams of Tripterygium wilfordii, 5 grams of Partridge tea, and 5 grams of Citrus aurantium. Example 3

[0041] A capsule for assisting the treatment of nephrotic syndrome, wherein the active components include the following raw materials by weight: 50 grams of silkworm pupa powder, 45 grams of Achyranthes bidentata powder, 18 grams of fermented cordyceps powder, 20 grams of Hibiscus truncatum pollen, 8 grams of yam powder, 6 grams of Begonia sibiricum root, 7 grams of Poria cocos, 5 grams of Rosa laevigata fruit, 4 grams of Lycium barbarum, 5 grams of Cuscuta australis, 20 grams of Tripterygium wilfordii, 4 grams of Partridge tea, and 3 grams of Citrus aurantium;

[0042] The above examples 1-3 adopt the following preparation method:

[0043] Step 1: according to the above formula, silkworm pupa powder, Achyranthes bidentata powder, fermented Cordyceps sinensis powder, Hibiscus truncatum pollen and Tripterygium wilfordii are mixed and stirred, ethanol is added for extraction, the mass volume ratio of the mixture to ethanol is 2.5:20 g / mL, the temperature is controlled to 70°C, the extraction time is 30min, an extract is obtained, the extract is concentrated for the first time to obtain a concentrated solution I, and then the concentrated solution I is filtered, the filtrate is extracted with chloroform at a volume ratio v / v of 5:10, the extraction temperature is 90°C, the extraction time is 30min, the chloroform layer is collected for a second concentration to obtain a concentrated solution II, the concentrated solution is passed through a silica gel column, eluted, and the eluate is collected for a third concentration to obtain a concentrated solution III for standby use;

[0044] Step 2: Mix yam powder, Malus opposita root and Citrus aurantium, add 2-5 times the mass of water of the mixture, stir the mixture evenly, heat at 110° C. for 25 min, remove impurities, filter, and dry to obtain a mixed extract;

[0045] Step 3: Mix and stir the above concentrate III and the mixed extract, Poria cocos, Rosa laevigata, Lycium barbarum, Cuscuta australis, and Partridge tea at a rate of 1700 rpm under ultrasonic wave action, with an ultrasonic wave power of 18-50 W, a frequency of 55 kHz, and a time of 40 min, and then filter and concentrate to obtain a Chinese medicine composition;

[0046] Step 4: Dry and crush the Chinese medicine composition to obtain powder, fill it into hollow capsules, ensure that the filling is uniform and tight, seal it, and package it to obtain a capsule for auxiliary treatment of nephrotic syndrome. Example 4

[0047] A capsule for assisting the treatment of nephrotic syndrome, wherein the active components include the following raw materials by weight: 50 grams of silkworm pupa powder, 45 grams of Achyranthes bidentata powder, 18 grams of fermented cordyceps powder, 20 grams of Hibiscus truncatum pollen, 8 grams of yam powder, 6 grams of Begonia sibiricum root, 7 grams of Poria cocos, 5 grams of Rosa laevigata fruit, 4 grams of Lycium barbarum, 5 grams of Cuscuta australis, 20 grams of Tripterygium wilfordii, 4 grams of Partridge tea, and 3 grams of Citrus aurantium;

[0048] The above-mentioned Example 4 adopts the following preparation method:

[0049] Step 1: according to the above formula, silkworm pupa powder, Achyranthes bidentata powder, fermented Cordyceps sinensis powder, Hibiscus truncatum pollen and Tripterygium wilfordii are mixed and stirred, ethanol is added for extraction, the mass volume ratio of the mixture to ethanol is 1.5:20 g / mL, the temperature is controlled to be 50° C., the extraction time is 20 min, an extract is obtained, the extract is concentrated for the first time to obtain a concentrated solution I, and then the concentrated solution I is filtered, the filtrate is extracted with chloroform at a volume ratio v / v of 3:10, the extraction temperature is 80° C., the extraction time is 25 min, the chloroform layer is collected for a second concentration to obtain a concentrated solution II, the concentrated solution is passed through a silica gel column, eluted, and the eluate is collected for a third concentration to obtain a concentrated solution III for standby use;

[0050] Step 2: Mix yam powder, Malus opposita root and Citrus aurantium, add water twice the mass of the mixture, stir the mixture evenly, heat at 100° C. for 20 min, remove impurities, filter, and dry to obtain a mixed extract;

[0051] Step 3: Mix and stir the above concentrate III and the mixed extract, Poria cocos, Rosa laevigata, Lycium barbarum, Cuscuta australis, and Partridge tea at a rate of 1500 rpm under ultrasonic wave action, with an ultrasonic wave power of 18 W, a frequency of 35 kHz, and a time of 20 min, and then filter and concentrate to obtain a Chinese medicine composition;

[0052] Step 4: Dry and crush the Chinese medicine composition to obtain powder, fill it into hollow capsules, ensure that the filling is uniform and tight, seal it, and package it to obtain a capsule for auxiliary treatment of nephrotic syndrome. Example 5

[0053] A capsule for assisting the treatment of nephrotic syndrome, wherein the active components include the following raw materials by weight: 50 grams of silkworm pupa powder, 45 grams of Achyranthes bidentata powder, 18 grams of fermented cordyceps powder, 20 grams of Hibiscus truncatum pollen, 8 grams of yam powder, 6 grams of Begonia sibiricum root, 7 grams of Poria cocos, 5 grams of Rosa laevigata fruit, 4 grams of Lycium barbarum, 5 grams of Cuscuta australis, 20 grams of Tripterygium wilfordii, 4 grams of Partridge tea, and 3 grams of Citrus aurantium;

[0054] The above-mentioned Example 5 adopts the following preparation method:

[0055] Step 1: according to the above formula, silkworm pupa powder, Achyranthes bidentata powder, fermented Cordyceps sinensis powder, Hibiscus truncatum pollen and Tripterygium wilfordii are mixed and stirred, ethanol is added for extraction, the mass volume ratio of the mixture to ethanol is 3.5:20 g / mL, the temperature is controlled to be 80° C., the extraction time is 40 min, an extract is obtained, the extract is concentrated for the first time to obtain a concentrated solution I, and then the concentrated solution I is filtered, the filtrate is extracted with chloroform at a volume ratio v / v of 8:10, the extraction temperature is 100° C., the extraction time is 35 min, the chloroform layer is collected for a second concentration to obtain a concentrated solution II, the concentrated solution is passed through a silica gel column, eluted, and the eluate is collected for a third concentration to obtain a concentrated solution III for standby use;

[0056] Step 2: Mix yam powder, Malus opposita root and Fructus aurantii, add water 5 times the mass of the mixture, stir the mixture evenly, heat at 120° C. for 30 min, remove impurities, filter, and dry to obtain a mixed extract;

[0057] Step 3: Mix and stir the above concentrate III and the mixed extract, Poria cocos, Rosa laevigata, Lycium barbarum, Cuscuta australis, and Partridge tea at a rate of 2000 rpm under ultrasonic wave action, with an ultrasonic wave power of 50 W, a frequency of 75 kHz, and a time of 60 min, and then filter and concentrate to obtain a Chinese medicine composition;

[0058] Step 4: Dry and crush the Chinese medicine composition to obtain powder, fill it into hollow capsules, ensure that the filling is uniform and tight, seal it, and package it to obtain a capsule for auxiliary treatment of nephrotic syndrome.

[0059] Test Example 1-Therapeutic Effect of the Pharmaceutical Composition of Example on Nephrotic Syndrome

[0060] 1. Model establishment: 40 male experimental mice weighing 150-200 g were selected, and the mice were adaptively raised and randomly divided into 4 groups: a physiological control group, a model control group, an embodiment 3 group, and an embodiment 5 group. Except for the physiological control group, the mice in the other groups were injected with doxorubicin 7 mg / kg by tail vein once a day, and the physiological control group was injected with 0.2 mL / mouse of normal saline. Two weeks after the injection, intraperitoneal administration was performed for 30 days. The medication conditions were: intraperitoneal injection of 0.5 ml / kg of the pharmaceutical composition of Example 3 of the present invention per day, intraperitoneal injection of 0.5 ml / kg of the pharmaceutical composition of Example 5 of the present invention per day, and intraperitoneal injection of 0.5 mL of normal saline per day in the physiological control group and the model control group.

[0061] 2. Observe symptoms: After the model is established, closely observe the symptoms of the mice. Nephrotic syndrome is usually manifested by urine protein, hypoproteinemia, serum creatinine, and hyperlipidemia. Observe symptoms by regularly checking urine and blood samples.

[0062] 3. Collect samples: During the experiment, urine and blood samples need to be collected regularly. Detect the protein content in urine by colorimetry or test strip method; detect serum albumin level by biochemical analyzer; detect blood creatinine by alkaline picric acid endpoint colorimetry; detect serum cholesterol and triglyceride levels by biochemical analyzer; the test results are shown in the table below:

[0063]

[0064] 4. Experimental results: The results of animal experiments show that the pharmaceutical compositions of Examples 3 and 5 of the present invention have certain effects in treating nephrotic syndrome. After administration, urine protein is significantly reduced and tends to normal levels, and serum albumin is increased, indicating that there is no hypoproteinemia, and the blood creatinine content returns to normal, indicating that the pharmaceutical composition of the present invention can excrete metabolic wastes such as creatinine from the body, the kidney function is normal, the serum cholesterol and triglyceride levels are normal, and there is no hyperlipidemia.

[0065] Test Example 2-Clinical Trial

[0066] 1. General information: There were 38 cases in total, aged between 30 and 80 years old, including 31 males and 7 females.

[0067] 2. Diagnostic criteria: "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases"

[0068] 3. Treatment method: The patient takes the medicine of Examples 3 and 5 of the present invention. Adults take 2 tablets 3 times a day, with warm water within half an hour after meals. One course of treatment is 7 days, and the medicine should be taken continuously for 3 to 4 courses.

[0069] 4. Efficacy criteria:

[0070] Markedly effective: The patient's main symptoms such as edema, proteinuria, hypoproteinemia, etc. were significantly relieved, laboratory indicators such as urine protein quantification, plasma albumin, blood lipids, etc. were significantly improved, and renal function was stable or improved.

[0071] Effective: The patient's main symptoms are relieved to a certain extent, and laboratory indicators are improved, but the degree of improvement is not as obvious as markedly effective.

[0072] Ineffective: The patient's main symptoms are not relieved, laboratory indicators do not improve or worsen, and renal function further deteriorates.

[0073] 5. Test results

[0074]

[0075] From the above results, it can be seen that the pharmaceutical composition of the present invention has the effects of promoting water and removing dampness, warming yang and strengthening the spleen, promoting qi and promoting water, helping to improve edema, effectively controlling hyperglycemia, helping to reduce proteinuria, regulating glucocorticoids, and inhibiting inflammatory and immune responses, thereby affecting the permeability of the glomerular basement membrane, and playing a role in eliminating proteinuria, helping to lower blood lipid levels, thereby alleviating the dyslipidemia symptoms of nephrotic syndrome.

[0076] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A capsule for assisting the treatment of nephrotic syndrome, characterized in that: The active components are composed of the following raw materials in parts by weight: 40-60 parts of silkworm pupa powder, 35-55 parts of Achyranthes bidentata powder, 15-22 parts of fermented cordyceps powder, 14-25 parts of hibiscus pollen, 5-11 parts of yam powder, 5-8 parts of crabapple roots, 5-8 parts of Poria cocos, 3-7 parts of Rosa laevigata fruit, 2-6 parts of wolfberry, 3-8 parts of Cuscuta australis, 15-25 parts of Tripterygium wilfordii, 3-5 parts of Partridge tea and 1-5 parts of Citrus aurantium.

2. A capsule for assisting the treatment of nephrotic syndrome as claimed in claim 1, characterized in that: The active group is composed of the following raw materials in parts by weight: 50 parts of silkworm pupa powder, 45 parts of Achyranthes bidentata powder, 18 parts of fermented cordyceps powder, 20 parts of hibiscus pollen, 8 parts of yam powder, 6 parts of crabapple roots, 7 parts of Poria cocos, 5 parts of Rosa laevigata fruit, 4 parts of wolfberry, 5 parts of Cuscuta australis, 20 parts of Tripterygium wilfordii, 4 parts of Partridge Tea, and 3 parts of Citrus aurantium.

3. A method for preparing a capsule for assisting the treatment of nephrotic syndrome as claimed in claim 1, characterized in that: The following steps are involved: Step 1: Mix and stir silkworm pupa powder, Achyranthes bidentata powder, fermented Cordyceps sinensis powder, Hibiscus truncatum pollen and Tripterygium wilfordii according to the above weight parts, add ethanol for extraction to obtain an extract, concentrate the extract for the first time to obtain a concentrated solution I, then filter the concentrated solution I, extract the filtrate with chloroform, collect the chloroform layer for the second concentration to obtain a concentrated solution II, pass it through a silica gel column, elute, collect the eluate for the third concentration to obtain a concentrated solution III for standby use; Step 2: Mix yam powder, Malus opposita root and Citrus aurantium, add 2-5 times the mass of water of the mixture, stir the mixture evenly, heat at 100-120° C. for 20-30 min, remove impurities, filter, and dry to obtain a mixed extract; Step 3: Mix and stir the above concentrated solution III and the mixed extract, Poria cocos, Rosa laevigata, Lycium barbarum, Cuscuta australis, and Partridge tea at a rate of 1500-2000 rpm under ultrasonic action, and then filter and concentrate to obtain a traditional Chinese medicine composition; Step 4: Dry and crush the Chinese medicine composition to obtain powder, fill it into hollow capsules, ensure that the filling is uniform and tight, seal it, and package it to obtain a capsule for auxiliary treatment of nephrotic syndrome.

4. A method for preparing a capsule for assisting the treatment of nephrotic syndrome as claimed in claim 3, characterized in that: The mass volume ratio of the mixture to ethanol in step 1 is 1.5-3.5:20 g / mL.

5. The method for preparing a capsule for assisting in the treatment of nephrotic syndrome as claimed in claim 3, characterized in that: The extraction temperature in step 1 is 50-80° C. and the extraction time is 20-40 min.

6. The method for preparing a capsule for assisting in the treatment of nephrotic syndrome as claimed in claim 3, characterized in that: The volume ratio v / v of the filtrate and chloroform in step 1 is 3-8:

10.

7. The method for preparing a capsule for assisting in the treatment of nephrotic syndrome as claimed in claim 3, characterized in that: In step 1, the extraction temperature is 80-100° C., and the extraction time is 25-35 minutes.

8. The method for preparing a capsule for assisting in the treatment of nephrotic syndrome as claimed in claim 3, characterized in that: In step 3, the ultrasonic power is 18-50W, the frequency is 35-75kHz, and the time is 20-60min.

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