A traditional Chinese medicine composition for treating wind-dry cough, its preparation method and uses

Abstract

The invention provides a Chinese medicine composition for treating dry cough caused by wind, which is prepared from the following raw materials in weight proportion: 6-12 parts of Radix Ophiopogonis, 6-12 parts of Radix Asparagi, 6-15 parts of Radix Chuanmingshen, 9-15 parts of Radix Adenophorae, 6-10 parts of Radix Belamcandae, 6-12 parts of Rhizoma Anemarrhenae, 5-10 parts of Folium Mori, 5-10 parts of Flos Coltsfoot, 6-12 parts of Plum, 9-15 parts of Momordica grosvenori, and 2-10 parts of Radix Glycyrrhizae. The Chinese medicine composition of the invention has the effects of nourishing yin and moistening the lungs, nourishing yin and moistening dryness, dispersing wind and dissipating heat, clearing away heat and detoxifying, and removing phlegm and relieving cough. It has a significant curative effect in treating dry cough caused by wind, and its drug effect is significantly better than that of Radix Ophiopogonis and Radix Ophiopogonis mixture, which not only conforms to the theoretical compatibility of traditional Chinese medicine, but also can exert the synergistic effect of drugs, and the components have a wide range of drug sources, no toxic side effects, and have clinical promotion value.

Description

Technical Field

[0001] The present invention relates to a traditional Chinese medicine composition for treating wind-dry cough. Background Art

[0002] Cough is a pulmonary disease mainly characterized by coughing sound or accompanied by expectoration. Cough is a protective respiratory reflex action for the human body to clear the secretions or foreign bodies in the respiratory tract. However, severe and long-term cough can lead to respiratory tract bleeding. Persistent and severe cough is also likely to consume physical strength and can cause damage to the alveolar elastic tissue, inducing pulmonary emphysema, bringing inconvenience to the majority of patients. Western medicine mainly focuses on anti-inflammation, with quick effects, but has large side effects and the condition is prone to recurrence. Traditional Chinese medicine believes that cough can be divided into exogenous cough and endogenous cough according to the cause. Exogenous cough is caused by the six exogenous pathogenic factors invading the lung qi, stagnating and closing the lung qi, and the lung losing its dispersing and descending functions, resulting in the upward reversal of the lung qi and the coughing up of phlegm. "All six qi of cold, summer heat, dryness, dampness, wind, and fire can cause cough." Clinically, it is mainly manifested as the combination of wind-cold, wind-heat, and wind-dryness and other diseases.

[0003] Wind-dry cough is caused by wind-heat invading the lung and dryness-heat injuring the lung. Wind is the first of the six exogenous pathogenic factors and is a yang pathogen. After a long time, it will turn into dryness. When dryness is excessive and body fluids are injured, the airway loses nourishment, resulting in dry cough and itchy throat, which are difficult to cure repeatedly. If the patient has a yin-deficient constitution, the deficiency of body fluids will be even more severe. Generally speaking, the etiology of wind-dry cough is wind-dryness injuring the lung, dryness-heat burning body fluids, and the lung losing its purifying and descending functions. The clinical manifestations are dry cough without phlegm, scanty and sticky phlegm, difficult to expectorate, or blood streaks in the phlegm, dry and painful throat, dry mouth and nose, red tip of the tongue, thin white or thin yellow and dry tongue coating, and floating and rapid pulse. The treatment is to disperse wind and clear the lung, moisten dryness and relieve cough. The representative formula is Sangxing Decoction. This formula adopts the method of pungent-cool and sweet-moistening, and is the representative formula for warm-dryness injuring the lung, and is only used for cough caused by warm-dryness injuring the lung. Erdong Ointment is a variety in the Chinese Pharmacopoeia, composed of Ophiopogon japonicus and Asparagus cochinchinensis, nourishing yin and moistening the lung, and is used for dry cough caused by insufficient lung yin. However, its application has certain limitations. For example, diabetics should use it with caution. Moreover, since wind-dry cough is caused by multiple factors, such as climate change, environmental factors, and individual constitution, these factors are intertwined, increasing the complexity of treatment. The symptoms of wind-dry cough are relatively stubborn, such as dry cough, scanty sputum, or blood streaks in the sputum, etc. These symptoms may last for a long time and are not easy to relieve. Traditional Chinese medicine treatment of cough emphasizes syndrome differentiation and treatment, and needs to carry out personalized treatment according to the specific symptoms and constitution of the patient, which puts forward higher requirements for the doctor's clinical experience and diagnostic ability; in addition, the treatment cycle of wind-dry cough is long, and the patient needs to adhere to taking traditional Chinese medicine or carry out other treatments, which is a test for the patient's compliance. It is still easy to relapse after treatment and requires long-term management and conditioning to reduce the possibility of recurrence.

[0004] Therefore, the difficulties in treating wind-dry cough lie in aspects such as complex etiology, stubborn symptoms, great difficulty in syndrome differentiation and treatment, long treatment cycle, easy recurrence, limitations of modern medicine, differences in patient cognition, and individual differences. Summary of the Invention

[0005] Based on the above existing problems, the present invention is based on traditional Chinese medicine theory, aiming at the pathogenesis of wind-dry cough, taking into account the etiological mechanism and disease transmission law of wind-dryness injuring the lung, and taking nourishing yin and moistening the lung, nourishing yin and moistening dryness, dispersing wind and clearing heat, clearing heat and detoxifying, resolving phlegm and relieving cough as the treatment principles, and carrying out dialectical compatibility and formula composition to achieve the purpose of treating both the symptoms and the root causes. The present invention provides a traditional Chinese medicine composition for treating wind-dry cough. The present invention also provides a preparation method and use of the traditional Chinese medicine composition.

[0006] The present invention provides a traditional Chinese medicine composition for treating wind-dry cough, which is prepared from the following raw materials in the following weight ratios:

[0007] 6-12 parts of Ophiopogon japonicus, 6-12 parts of Asparagus cochinchinensis, 6-15 parts of Chuanminshen violaceum, 9-15 parts of Adenophora tetraphylla, 6-10 parts of Belamcanda chinensis, 6-12 parts of Anemarrhena asphodeloides, 5-10 parts of Morus alba leaves, 5-10 parts of Tussilago farfara, 6-12 parts of Prunus mume, 9-15 parts of Momordica grosvenori, 2-10 parts of Glycyrrhiza uralensis.

[0008] Further preferably, it is prepared from the following raw materials in the following weight ratios:

[0009] 10 parts of Ophiopogon japonicus, 10 parts of Asparagus cochinchinensis, 6 parts of Chuanminshen violaceum, 9 parts of Adenophora tetraphylla, 6 parts of Belamcanda chinensis, 6 parts of Anemarrhena asphodeloides, 6 parts of Morus alba leaves, 6 parts of Tussilago farfara, 6 parts of Prunus mume, 9 parts of Momordica grosvenori, 6 parts of Glycyrrhiza uralensis.

[0010] The traditional Chinese medicine composition of the present invention uses the crude drugs of the above raw materials, water or organic solvent extracts as active ingredients, and adds pharmaceutically acceptable excipients or auxiliary ingredients to prepare pharmaceutically common preparations.

[0011] Among them, the preparation is a granule, a mixture, a syrup, an extract, a tablet, a capsule, an oral liquid.

[0012] The present invention provides a preparation method of the traditional Chinese medicine composition for treating wind-dry cough, which comprises the following steps:

[0013] a. Weigh the raw materials in the respective weight ratios;

[0014] b. Powder the raw materials, or extract them with water or an organic solvent. After concentrating the extract, add pharmaceutically acceptable excipients or auxiliary ingredients to prepare pharmaceutically common preparations.

[0015] The present invention provides the use of the pharmaceutical composition in the preparation of a drug for treating wind-dry cough.

[0016] Among them, the drug is used for scanty dry phlegm and dry nose and sore throat caused by wind-dryness injuring the lung.

[0017] The present invention provides the use of the pharmaceutical composition in the preparation of a drug with the efficacy of nourishing yin and moistening the lung, nourishing yin and moistening dryness.

[0018] Ophiopogon Root: The dried tuberous roots of Ophiopogon japonicus (L.f) Ker-Gawl., a plant of the Liliaceae family. Sweet, slightly bitter, and slightly cold. It acts on the heart, lung, and stomach meridians. It nourishes yin and promotes the production of body fluids, moistens the lung and clears the heart. It is used for dry cough due to lung dryness, consumptive cough due to yin deficiency, sore throat, thirst due to fluid impairment, internal heat with polydipsia, restlessness and insomnia, and constipation due to intestinal dryness. Ophiopogon Root "treats the fire hidden in the lung" (Compendium of Materia Medica).

[0019] Asparagus Root: The dried tuberous roots of Asparagus cochinchinensis (Lour.) Merr., a plant of the Liliaceae family. Sweet, bitter, and cold. It acts on the lung and kidney meridians. It nourishes yin and moistens dryness, clears the lung and promotes the production of body fluids. It is used for dry cough due to lung dryness, sticky phlegm in paroxysmal cough, soreness of the waist and knees, hectic fever due to yin deficiency, internal heat with polydipsia, injury of body fluids due to febrile diseases, dryness and thirst in the throat, and constipation due to intestinal dryness. Asparagus Root "moistens the lung and nourishes yin, clears the lung and reduces fire" (Compendium of Materia Medica).

[0020] Chuanminshen Root: The dried roots of Chuanmingshen violaceum Sheh et Shan, a plant of the genus Chuanmingshen in the Umbelliferae family. Sweet, flat, slightly bitter, and cool. It acts on the lung and liver meridians. It nourishes yin and tonifies the lung, strengthens the spleen. It is used for syndromes of yin deficiency in the lung, injury of yin due to febrile diseases, cough due to lung heat, poor appetite due to spleen deficiency, and weakness after illness.

[0021] Southern Adenophora Root: The dried roots of Adenophora tetraphylla (Thunb.) Fisch. or Adenophora stricta Miq., plants of the Campanulaceae family. Sweet and slightly cold. It acts on the lung and stomach meridians. It nourishes yin and clears the lung, promotes the production of body fluids in the stomach, resolves phlegm, and supplements qi. It is used for dry cough due to lung heat and dryness, consumptive cough due to yin deficiency, sticky phlegm in dry cough, insufficiency of stomach yin, poor appetite and vomiting, insufficiency of qi and yin, restlessness and thirst. Southern Adenophora Root is good at entering the lung and is inclined to clear the lung, resolve phlegm, and relieve cough. "Clears the lung fire and treats chronic cough and lung atrophy" (Compendium of Materia Medica).

[0022] Rhizoma Belamcandae: The dried rhizomes of Iris tectorum Maxim., a plant of the Iridaceae family. Bitter and cold. It acts on the lung meridian. It clears heat and detoxifies, resolves phlegm, and soothes the throat. It is used for the binding of heat-toxin and phlegm-fire, sore throat, profuse phlegm, cough, and asthma. Rhizoma Belamcandae in "Shennong's Herbal Classic" "treats cough with dyspnea and sore throat".

[0023] Anemarrhena Rhizome: The dried rhizomes of Anemarrhena asphodeloides Bge., a plant of the Liliaceae family. Bitter, sweet, and cold. It acts on the lung, stomach, and kidney meridians. It clears heat and purges fire, nourishes yin and moistens dryness. It is used for exogenous febrile diseases, high fever and restlessness, dry cough due to lung heat and dryness, hectic fever due to yin deficiency, internal heat with polydipsia, and constipation due to intestinal dryness.

[0024] Mulberry Leaf: The dried leaf of Morus alba L., a plant of the Moraceae family. Sweet, bitter, and cold in nature. It acts on the lung and liver meridians. It disperses wind-heat, moistens the lung and relieves dryness, and clears the liver and improves eyesight. It is used for wind-heat colds, dry coughs due to lung heat, dizziness and headache, and red and hazy eyes. Bitter and cold, it purges lung heat; sweet and cold, it nourishes yin and moistens the lung to relieve dryness, and is used for dryness injuring the lung.

[0025] Flos Farfarae: The dried flower buds of Tussilago farfara L., a plant of the Asteraceae family. Pungent, slightly bitter, and warm in nature. It acts on the lung meridian. It moistens the lung and descends qi, relieves cough and reduces phlegm. It is used for new and chronic coughs, profuse phlegm with wheezing, and hemoptysis due to consumptive cough. In "Shennong Ben Cao Jing", it is stated that "it is mainly used for cough and dyspnea"; in "Ben Jing Feng Yuan", it is said that "it moistens the lung and eliminates phlegm".

[0026] Fructus Mume: The dried nearly ripe fruit of Prunus mume (Sieb.) Sieb. et Zucc., a plant of the Rosaceae family. Sour, astringent, and neutral in nature. It acts on the liver, spleen, lung, and large intestine meridians. It astringes the lung, arrests diarrhea, generates fluid, and expels roundworms. It is used for chronic cough due to lung deficiency, chronic diarrhea and dysentery, consumptive thirst with deficiency heat, and vomiting and abdominal pain due to roundworm syncope.

[0027] Fructus Momordicae Grosvenorii: The dried fruit of Siraitia grosvenorii (Swingle) C. Jeffrey ex A. M. Lu et Z. Y. Zhang, a plant of the Cucurbitaceae family. Sweet and cool in nature. It acts on the lung and large intestine meridians. It clears heat and moistens the lung, soothes the throat and promotes voice production, and lubricates the intestines and promotes defecation. It is used for dry cough due to lung heat, sore throat with loss of voice, and constipation due to intestinal dryness.

[0028] Radix Glycyrrhizae: The dried roots and rhizomes of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat., or Glycyrrhiza glabra L., plants of the Leguminosae family. Sweet and neutral in nature. It acts on the heart, lung, spleen, and stomach meridians. It invigorates the spleen and replenishes qi, clears heat and detoxifies, reduces phlegm and relieves cough, alleviates spasm and pain, and harmonizes various medicinal herbs. It is used for weakness of the spleen and stomach, lassitude and fatigue, palpitations and shortness of breath, profuse phlegm with cough, spasmodic pain in the epigastric and abdominal regions and limbs, carbuncles and sores, and relieves the toxicity and potency of medicinal herbs.

[0029] In the drug raw material formula of the present invention, Radix Ophiopogonis and Radix Asparagi nourish yin and moisten the lungs, promote fluid production and moisten dryness, and are used for dry cough with less sputum, blood in sputum, dry nose and sore throat caused by insufficient lung yin, and are the main medicines; Radix Glehniae Sinensis nourishes yin and nourishes the lungs; Radix Adenophorae Sinensis nourishes yin and moistens the lungs; Radix Belamcandae Sinensis clears heat and detoxifies, removes phlegm and relieves sore throat; Rhizoma Anemarrhenae clears heat and purges fire, nourishes yin and moistens dryness; the four are ministerial medicines, to help the main medicine nourish yin, moisten dryness, clear lungs and relieve sore throat. Mulberry leaves are light and clear to disperse dryness and heat, Coltsfoot Flower moistens the lungs and lowers Qi, relieves cough and resolves phlegm, Plum Blossoms astringes the lungs, and is used for chronic cough caused by lung deficiency, and Momordica grosvenori clears heat and moistens the lungs, relieves sore throat and relieves voice. The four are adjuvants, clearing lung heat, moistening lung dryness, astringing lung Qi, and lowering lung reversal, to assist the main medicine in treating wind-dry cough. Licorice nourishes the spleen and replenishes Qi, clears heat and detoxifies, removes phlegm and relieves cough, and harmonizes various medicines, and is the guiding medicine. In short, the combination of these medicines can nourish yin and moisten the lungs, nourish yin and moisten dryness, clear away heat and detoxify, and eliminate phlegm and relieve cough, so as to achieve the purpose of treating both the symptoms and the root cause.

[0030] The Chinese medicine composition of the present invention has the effects of nourishing yin and moistening the lungs, nourishing yin and moistening dryness, dispersing wind and heat, clearing away heat and detoxifying, and removing phlegm and relieving cough. It has a significant effect on treating wind-dryness cough, and its drug effect is significantly better than that of Radix Ophiopogonis and Radix Ophiopogonis mixture. It not only conforms to the theoretical compatibility of traditional Chinese medicine, but also can exert the synergistic effect of drugs. The components have a wide range of drug sources, are non-toxic and have no side effects, and have clinical promotion value. DETAILED DESCRIPTION

[0031] Example 1: Preparation of the Chinese medicine composition granules

[0032] [Prescription] Ophiopogon japonicus 10g Asparagus cochinchinensis 10g Sichuan radix 6g Adenophora australis 9g Sichuan radix 6g

[0033] Anemarrhena 6g Mulberry Leaf 6g Coltsfoot Flower 6g Black Plum 6g Momordica grosvenori 9g Licorice 6g

[0034] Weigh 10 times the amount of each medicine in the prescription, a total of 800g, add water and boil three times, each time the amount of water is 10 times the amount of the medicinal materials (V / W), each time for 1 hour, combine the decoctions, filter, concentrate to an extract with a relative density of 1.25-1.30 (60℃), dry under reduced pressure at 60℃ to obtain a dry paste, crush, add dextrin to 450g, mix well, make into granules, dry, and granulate.

[0035]

Specification

[0036] [Usage and Dosage] Oral administration, three times a day, one bag each time.

[0037] Example 2: Preparation of the Chinese medicine composition

[0038] [Prescription] Ophiopogon japonicus 10g Asparagus cochinchinensis 10g Sichuan radix 6g Adenophora australis 9g Sichuan radix 6g

[0039] Anemarrhena 6g Mulberry Leaf 6g Coltsfoot Flower 6g Black Plum 6g Momordica grosvenori 9g Licorice 6g

[0040] Weigh 10 times the amount of each drug in the prescription, a total of 800 g. Decoct with water three times. Each time, the water consumption is 10 times that of the medicinal materials (V / W), and each decoction lasts for 1 hour. Combine the decoction liquids, filter, concentrate to about 1000 ml, let stand for 24 hours, filter, add 3 g of sodium benzoate and 1 g of steviol glycoside, add water to 1000 ml, and stir well to obtain the product.

[0041]

Specification

[0042]

Dosage and Administration

[0043] Example 3: Preparation of the syrup of the traditional Chinese medicine composition

[0044]

Prescription

[0045] 6 g of Anemarrhena asphodeloides, 6 g of Morus alba, 6 g of Tussilago farfara, 6 g of Prunus mume, 9 g of Momordica grosvenori, 6 g of Glycyrrhiza uralensis

[0046] Weigh 10 times the amount of each drug in the prescription, a total of 800 g. Decoct with water three times. Each time, the water consumption is 10 times that of the medicinal materials (V / W), and each decoction lasts for 1 hour. Combine the decoction liquids, filter, let stand, take the supernatant, concentrate to an appropriate amount, add 400 g of sucrose and 0.1 g of ethylparaben, boil to dissolve, filter, add water to the filtrate to 1000 ml, and stir well to obtain the product.

[0047]

Specification

[0048]

Dosage and Administration

[0049] Example 4: Preparation of the extract paste of the traditional Chinese medicine composition

[0050]

Prescription

[0051] 6 g of Anemarrhena asphodeloides, 6 g of Morus alba, 6 g of Tussilago farfara, 6 g of Prunus mume, 9 g of Momordica grosvenori, 6 g of Glycyrrhiza uralensis

[0052] Weigh 10 times the amount of each drug in the prescription, a total of 800 g. Decoct with water three times. Each time, the water consumption is 10 times that of the medicinal materials (V / W), and each decoction lasts for 1 hour. Combine the decoction liquids, filter, and concentrate the filtrate into a clear paste with a relative density of 1.21 - 1.25 (80 °C). Add 50 g of refined honey to every 100 g of the clear paste, mix well to obtain the product.

[0053]

Specification

[0054]

Dosage and Administration

[0055] The beneficial effects of the present invention are demonstrated by the following pharmacodynamic experiments.

[0056] Experimental Example 1 Animal Experiment of the Drug of the Invention

[0057] Experimental animals: Mice, half male and half female, weighing 18 - 22 g, clean grade, SPF animal laboratory of the Experimental Animal Center of Sichuan Academy of Traditional Chinese Medicine, Animal Use License: SYXK (Sichuan) 2003 - 0100 Experimental drugs:

[0058] The anti - dry - wind cough mixture of the present invention (each ml is equivalent to 0.8 g of crude drug, see Example 1 for details)

[0059] Ophiopogon japonicus and Asparagus cochinchinensis mixture: Weigh 400 g each of Ophiopogon japonicus and Asparagus cochinchinensis, a total of 800 g. Decoct with water three times, each time using 10 times the amount of water as the medicinal materials (V / W), each time for 1 hour. Combine the decoctions, filter, concentrate to about 1000 ml, let stand for 24 hours, filter, add 3 g of sodium benzoate and 1 g of steviol glycoside, add water to 1000 ml, stir well, and obtain (each ml is equivalent to 0.8 g of crude drug).

[0060] I. Cough - relieving test of the anti - dry - wind cough mixture - Ammonia - induced cough method in mice

[0061] Test method:

[0062] Take 80 mice weighing 18 - 22 g, half male and half female. Randomly divide them into 8 groups according to gender and weight, with 10 mice in each group. Gastrically administer the anti - dry - wind cough mixture, Ophiopogon japonicus and Asparagus cochinchinensis mixture at 3.0, 1.5, 0.75 g / kg respectively and the positive control drug codeine phosphate (the blank control group is given the same volume of distilled water) for 7 days. 40 minutes after the last administration, place the mice in an inverted 500 - ml beaker respectively, and inject 0.15 ml of concentrated ammonia water into a small cup placed in the beaker. Stimulate the mice for 15 s, take out the mice, observe the number of coughs of the mice within 2 min, and conduct data statistics. The results are shown in Table 1.

[0063] Table 1 Cough - relieving test of the anti - dry - wind cough mixture (Ammonia - induced cough method)

[0064]

[0065]

[0066] Note: **P < 0.01, *P < 0.05 (compared with the blank group)

[0067] As can be seen from the above table, the drug of the present invention has an obvious cough - relieving effect, is significant compared with the blank group, and is superior to the Ophiopogon japonicus and Asparagus cochinchinensis mixture with the same amount of crude drug.

[0068] II. Cough - relieving test of the anti - dry - wind cough mixture - SO 2 Induced cough method

[0069] Test method: 80 mice weighing 18 - 22 g, with an equal number of males and females, were randomly divided into 8 groups of 10 mice each according to gender and body weight. They were intragastrically administered Fengzao Cough Mixture, Maidong Dongdong Mixture at doses of 3.0, 1.5, 0.75 g / kg respectively, and the positive control drug codeine phosphate (the blank control group was given the same volume of distilled water) for 7 days. 1 hour after the last administration, 0.5 g of anhydrous sodium sulfite was placed in a 50 mL small beaker, and 5 mL of 50% sulfuric acid solution was quickly added. Immediately, a 1000 mL glass beaker was inverted over the small beaker. After 1 minute, the mice were quickly placed into the inverted large beaker, 2 mice each time. The coughing situation of the mice was observed within 2 minutes, and the number of coughs of the mice was recorded. The cough inhibition rate was calculated. The results are shown in Table 2.

[0070] Table 2 Cough Suppressant Test of Fengzao Cough Mixture (SO 2 Cough Induction Method)

[0071] Group Dose (g / kg) Number of coughs Inhibition rate (%) Blank group (distilled water) / 55.5±1.7 / High dose of Fengzao Cough Mixture 3.0 28.1±2.3** 49.37 Medium dose of Fengzao Cough Mixture 1.5 35.4±2.5* 36.22 Low dose of Fengzao Cough Mixture 0.75 40.3±3.1 27.39 High dose of Maidong Dongdong Mixture 3.0 30.8±1.8* 40.90 Medium dose of Maidong Dongdong Mixture 1.5 37.2±2.7* 32.97 Low dose of Maidong Dongdong Mixture 0.75 42.7±2.1 23.06 Codeine phosphate 30mg / kg 26.0±2.2** 53.15

[0072] Note: **P < 0.01, *P < 0.05 (compared with the blank group)

[0073] As can be seen from the above table, the drug of the present invention has an obvious cough suppressant effect, is significant compared with the blank group, and is superior to Maidong Dongdong Mixture with the same raw drug dosage.

[0074] III. Cough Suppressant Test of Fengzao Cough Mixture - Mouse Citric Acid Cough Induction Method

[0075] Test method: 80 mice weighing 18 - 22 g, with an equal number of males and females, were randomly divided into 8 groups of 10 mice each according to gender and body weight. They were intragastrically administered Fengzao Cough Mixture, Maidong Dongdong Mixture at doses of 3.0, 1.5, 0.75 g / kg respectively, and the positive control drug codeine phosphate (the blank control group was given the same volume of distilled water) for 7 days. 1 hour after the last administration, 17.5% citric acid was sprayed for 40 s (adjust the flow rate to 10 L·min -1 ), and timing started after the spraying stopped. The coughing situation of the mice was observed within 5 minutes, and the number of coughs of the mice was recorded. The cough inhibition rate was calculated. The results are shown in Table 3.

[0076] Table 3 Cough Suppressant Test of Fengzao Cough Mixture (Citric Acid Cough Induction Method)

[0077] Group Dose (g / kg) Number of coughs Inhibition rate (%) Blank group (distilled water) / 25.2±3.5 / High dose of Fengzao Cough Mixture 3.0 16.3±3.0* 35.32 Medium dose of Fengzao Cough Mixture 1.5 16.8±2.8* 33.33 Low dose of Fengzao Cough Mixture 0.75 19.3±3.1 23.41 High dose of Maidong Dongdong Mixture 3.0 17.3±3.1* 32.54 Medium dose of Maidong Dongdong Mixture 1.5 18.0±2.2* 28.87 Low dose of Maidong Dongdong Mixture 0.75 20.5±2.4 18.65 Codeine phosphate 30mg / kg 14.4±3.6** 42.86

[0078] Note: **P < 0.01, *P < 0.05 (compared with the blank group)

[0079] As can be seen from the above table, the drug of the present invention has an obvious cough suppressant effect, is significant compared with the blank group, and is superior to Maidong Dongdong Mixture with the same raw drug dosage.

[0080] Test Example 2 Clinical Typical Cases of the Drug of the Present Invention

[0081] Zhang, 34 years old, male. The patient has a dry cough, with no sputum or a small amount of sticky sputum that is not easily expectorated. The tongue coating is thin, yellow, and dry, and the pulse is floating and rapid. Diagnosed with wind-dryness cough, treated with Fengzao Kesou Granules, three times a day, one bag each time. After taking for 3 days, the symptoms were cured.

[0082] Lei, male, 52 years old. He has a dry cough, dry lips and nose, nasal congestion, headache, red tongue, thin yellow tongue coating, and floating and rapid pulse. Diagnosed with wind-dryness cough, treated with Fengzao Kesou Syrup, 30 ml each time, three times a day. After taking for 3 days, the symptoms were basically cured.

[0083] Ms. Li, 45 years old. She has a dry cough, coughing continuously and spasmodically, itchy throat, dry and painful throat, dry lips and nose, no sputum, dry mouth accompanied by nasal congestion, little and sticky sputum, and a red tongue. Diagnosed with wind-dryness cough, treated with Fengzao Kesou Mixture, 30 ml each time, three times a day. After taking for 3 days, the symptoms were basically cured.

Claims

1. A Chinese medicine composition for treating dry cough, characterized in that: It is prepared from the following raw materials in the following weight ratio: 10 parts of Radix Ophiopogonis, 10 parts of Asparagus cochinchinensis, 6 parts of Radix Glehniae, 9 parts of Radix Adenophorae, 6 parts of Rhizoma Belamcandae, 6 parts of Rhizoma Anemarrhenae, 6 parts of Folium Mori, 6 parts of Flos Coltsfoot, 6 parts of Plums Ebony, 9 parts of Momordica grosvenori, and 2. The Chinese medicine composition for treating wind-dry cough according to claim 1, characterized in that: The raw medicinal material, water or organic solvent extract of the raw material medicine are used as active ingredients, and pharmaceutically acceptable auxiliary materials are added to prepare a commonly used pharmaceutical preparation.

3. The Chinese medicine composition for treating wind-dry cough according to claim 2, characterized in that: The preparation is tablet, capsule, granule or oral liquid.

4. A method for preparing the Chinese medicine composition for treating wind-dry cough according to any one of claims 1 to 3, characterized in that: It includes the following steps: a. Weigh the APIs of various weight ratios; b. The raw material drug is powdered, or extracted by adding water or organic solvent. After the extract is concentrated, pharmaceutically acceptable excipients are added to prepare a commonly used pharmaceutical preparation.

5. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating dry cough.

6. The use according to claim 5, characterized in that: The medicine is used for dry cough with little sputum, dry nose and sore throat caused by wind-dryness damaging the lungs.

7. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicine having the effects of nourishing yin and moistening the lungs, and nourishing yin and moistening dryness.

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