A traditional Chinese medicine liqueur for nourishing kidney yang and improving sleep, its preparation method and application.

Abstract

This invention provides a traditional Chinese medicine liqueur for nourishing kidney yang and improving sleep, along with its preparation method and application, relating to the field of liqueur brewing technology. The traditional Chinese medicine used in the liqueur of this invention includes the following ingredients in parts by weight: 10-30 parts of Cistanche deserticola, 20-50 parts of Ziziphus jujuba var. spinosa, 8-25 parts of Dioscorea opposita, 8-25 parts of Polygonatum sibiricum, 2-8 parts of Panax ginseng, 8-25 parts of Astragalus membranaceus, 2-8 parts of Dendrobium officinale, 5-20 parts of Pueraria lobata, and 2-8 parts of Cinnamomum cassia. This invention uses a strong-aroma or sauce-aroma type of baijiu (Chinese white liquor) as a base, adding the above-mentioned traditional Chinese medicine composition to produce the liqueur. The liqueur product prepared by this invention has a light color, similar to the original base liquor, fully retaining the original base liquor's color, aroma, and flavor, and has the effect of nourishing kidney yang and improving sleep quality.

Description

Technical Field

[0001] This invention belongs to the field of liqueur brewing technology, specifically a traditional Chinese medicine liqueur that nourishes kidney yang and improves sleep, as well as its preparation method and application. Background Technology

[0002] Liqueurs are a product of thousands of years of understanding and practice of integrating wine and medicine. They possess a unique design style and are a type of alcoholic beverage with a distinctive flavor. Furthermore, the rich variety of ingredients available in liqueurs allows them to meet diverse and personalized needs. When combined with traditional Chinese medicine, adding "health" elements to the base of alcoholic beverages is also a way to realize the principles of TCM health preservation. At the same time, the health and wellness value of liqueurs is released, better aligning with the expectation of healthy drinking. Therefore, liqueurs, combining health preservation and leisure characteristics, have become a new direction in the beverage market.

[0003] Liqueurs are primarily made from a base spirit and raw materials using advanced processing techniques. A wide variety of raw materials are available, especially with the advancements in applied technology in recent years, expanding the application range and creating a broad market prospect. Examples include goji berries, jujubes, ginseng, angelica, and cinnamon; essentially, any edible or medicinal ingredient can be used to produce liqueurs. Traditional liqueur preparation methods generally include maceration, distillation, and refining, all requiring the direct or indirect maceration or blending of medicinal herbs with the base spirit, and prohibiting the addition of food additives. Due to the diverse tastes, colors, and numerous main components of medicinal herbs, commercially available liqueurs are often dark in color, sometimes even slightly cloudy, and have an overly strong medicinal flavor, completely masking the color, aroma, and taste of the original base spirit. Therefore, maintaining a clear, transparent liqueur with a light color, closely resembling the original base spirit's color, aroma, and taste, while simultaneously offering both health benefits and the pleasure of drinking, is crucial for product development.

[0004] Kidney deficiency is common in modern populations, and it can trigger a series of pathological symptoms. Kidney deficiency is also a fundamental cause of aging, leading to various chronic diseases. Li Chan of the Ming Dynasty stated in his "Medical Orthodox Transmission" that "As people reach middle age, their kidney qi declines daily, and coupled with excessive indulgence in sexual activity, this leads to weakness and decline." Therefore, tonifying the kidneys has become crucial for health preservation and disease prevention. Insomnia caused by kidney yang deficiency is increasingly prevalent. For example, the elderly often experience insomnia and short sleep duration, while young people who frequently stay up late cannot preserve their yang qi. Excessive consumption of raw and cold foods and overuse of air conditioning will inevitably damage the kidneys, harming the kidney's yang qi and causing insomnia. Summary of the Invention

[0005] In view of this, the purpose of the present invention is to provide a traditional Chinese medicine liqueur that nourishes kidney yang and improves sleep, as well as its preparation method and application. The traditional Chinese medicine liqueur of the present invention has a light color, which is similar to the color of the original wine base, fully retains the color, aroma and taste of the original wine base, and has the effect of nourishing kidney yang and improving sleep quality.

[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0007] This invention provides a traditional Chinese medicine liqueur that nourishes kidney yang and improves sleep. The traditional Chinese medicine used includes the following raw materials in parts by weight: 10-30 parts of Cistanche deserticola, 20-50 parts of Ziziphus jujuba var. spinosa, 8-25 parts of Dioscorea opposita, 8-25 parts of Polygonatum sibiricum, 2-8 parts of Panax ginseng, 8-25 parts of Astragalus membranaceus, 2-8 parts of Dendrobium officinale, 5-20 parts of Pueraria lobata, and 2-8 parts of Cinnamomum cassia.

[0008] Preferably, the herbal liqueur uses strong-aroma or sauce-aroma baijiu as its base.

[0009] This invention also provides a method for preparing the aforementioned traditional Chinese medicine liqueur that nourishes kidney yang and improves sleep, comprising the following steps:

[0010] After freeze-drying, the jujube seeds are broken down and pulverized, then ethanol is added for soaking to obtain a jujube seed soaking solution; the jujube seed soaking solution is centrifuged and filtered to obtain a jujube seed filtrate and a jujube seed residue; the jujube seed filtrate is recovered with ethanol and evaporated to obtain a jujube seed evaporated product;

[0011] The remaining medicinal materials are sliced ​​while fresh, freeze-dried, and pulverized. They are then added to the above-mentioned jujube seed residue, decocted, centrifuged, and filtered to obtain the supernatant. The supernatant is then evaporated and combined with the evaporated jujube seed residue. Ethanol is added to redissolve the residue, and centrifuged and filtered to obtain the filtrate. The filtrate is then decolorized, centrifuged, filtered, and the ethanol is recovered and evaporated. A base alcohol is added, and the mixture is ultrasonically treated and filtered through a microporous membrane to obtain the traditional Chinese medicine liqueur.

[0012] Preferably, the ethanol concentration during the ethanol soaking of the jujube kernels is 50-70%.

[0013] More preferably, the impregnation time is 2 to 5 days.

[0014] Preferably, the particle size of the Chinese herbal medicine after cell wall breaking and pulverization is less than 45 μm.

[0015] Preferably, the weight ratio of Chinese medicine to water during decoction is 1:6 to 8.

[0016] Preferably, the decocting time is 1 to 2 hours per batch.

[0017] Preferably, the decolorization treatment is performed using 0.5-2% activated carbon in a water bath at 55-65°C for 0.5-2 hours.

[0018] Preferably, the ultrasonic treatment time is 25 to 35 minutes.

[0019] Compared with the prior art, the present invention has the following advantages:

[0020] This invention provides a traditional Chinese medicine liqueur for nourishing kidney yang and improving sleep. The herbs used include Cistanche deserticola, Ziziphus jujuba var. spinosa, Dioscorea opposita, Polygonatum sibiricum, Astragalus membranaceus, Ginseng, Dendrobium officinale, Pueraria lobata, and Cinnamomum cassia. Cistanche deserticola and Ziziphus jujuba var. spinosa are the principal herbs, tonifying kidney yang, replenishing essence and blood, and calming the mind. To prevent the deficiency of yang energy, Dioscorea opposita and Polygonatum sibiricum are added as assistant herbs to nourish the kidneys, replenish yin, and generate fluids, achieving a yang-tonifying effect within yin. Since the kidneys are the foundation of innate constitution and the spleen is the foundation of acquired constitution, tonifying the kidneys should also consider replenishing qi and strengthening the spleen. Astragalus membranaceus and Ginseng are added as assistant herbs to invigorate the spleen and raise yang. Dendrobium officinale and Pueraria lobata are added to enhance the fluid-generating effect and detoxify alcohol. Cinnamomum cassia tonifies fire and assists yang, guiding fire back to its source, warming yang and unblocking the meridians, and guiding the medicine into the meridians. This invention selects edible traditional Chinese medicinal materials with kidney-tonifying, yang-boosting, and calming effects, enabling the prepared liqueur to achieve a good effect of nourishing kidney yang and improving sleep quality. Meanwhile, the preparation method of the traditional Chinese medicine liqueur described in this invention can fully preserve the color, aroma, and flavor of the original wine base, making the liqueur clear and transparent. Attached Figure Description

[0021] Figure 1 The images show a color comparison of the herbal liqueur of this invention treated with different decolorization processes. In the images, a is the undecolorized herbal liqueur, b is the herbal liqueur after decolorization with 0.5% activated carbon, c is the herbal liqueur after decolorization with 1.0% activated carbon, d is the herbal liqueur after decolorization with 2.0% activated carbon, e is the herbal liqueur after decolorization with 0.5% macroporous resin, f is the herbal liqueur after decolorization with 1.0% macroporous resin, and g is the herbal liqueur after decolorization with 2.0% macroporous resin. Detailed Implementation

[0022] This invention provides a traditional Chinese medicine liqueur for nourishing kidney yang and improving sleep. The preferred ingredients include the following parts by weight: 10-30 parts of Cistanche deserticola, 20-50 parts of Ziziphus jujuba var. spinosa, 8-25 parts of Dioscorea opposita, 8-25 parts of Polygonatum sibiricum, 2-8 parts of Panax ginseng, 8-25 parts of Astragalus membranaceus, 2-8 parts of Dendrobium officinale, 5-20 parts of Pueraria lobata, and 2-8 parts of Cinnamomum cassia. More preferably, the ingredients include the following parts by weight: 12-25 parts of Cistanche deserticola... The ingredients are: 25-45 parts of Ziziphus jujuba seed, 10-20 parts of Dioscorea opposita, 10-20 parts of Polygonatum sibiricum, 3-6 parts of ginseng, 10-20 parts of Astragalus membranaceus, 3-6 parts of Dendrobium officinale, 8-15 parts of Pueraria lobata, and 3-6 parts of Cinnamomum cassia. Preferably, the Chinese medicinal herbs used include the following ingredients by weight: 20 parts of Cistanche deserticola, 40 parts of Ziziphus jujuba seed, 15 parts of Dioscorea opposita, 15 parts of Polygonatum sibiricum, 5 parts of ginseng, 15 parts of Astragalus membranaceus, 5 parts of Dendrobium officinale, 10 parts of Pueraria lobata, and 5 parts of Cinnamomum cassia. This invention does not have a specific limitation on the source of the Chinese medicinal herbs; conventional commercially available products are acceptable.

[0023] In this invention, the herbal liqueur is preferably made from strong-aroma or sauce-aroma baijiu as the base.

[0024] This invention also provides a method for preparing the aforementioned traditional Chinese medicine liqueur that nourishes kidney yang and improves sleep, comprising the following steps:

[0025] After freeze-drying, the jujube seeds are broken down and pulverized, then ethanol is added for soaking to obtain a jujube seed soaking solution; the jujube seed soaking solution is centrifuged and filtered to obtain a jujube seed filtrate and a jujube seed residue; the jujube seed filtrate is recovered with ethanol and evaporated to obtain a jujube seed evaporated product;

[0026] The remaining medicinal materials are sliced ​​or segmented while fresh, then freeze-dried and pulverized. They are then added to the above-mentioned jujube seed residue, decocted, and centrifuged to obtain the supernatant. The supernatant is then evaporated and combined with the evaporated jujube seed residue. Ethanol is added to redissolve the residue, and centrifuged to obtain the filtrate. The filtrate is then decolorized, centrifuged, filtered, and the ethanol is recovered and evaporated. A base alcohol is added, and the mixture is ultrasonically treated and filtered through a microporous membrane to obtain the Chinese herbal liqueur.

[0027] In this invention, each component in the formula is weighed according to its weight. Except for jujube seed, the other medicinal materials are freeze-dried and then pulverized to below 45μm. They are then placed in a mixing container and mixed evenly.

[0028] In this invention, jujube seeds that have undergone freeze-drying are pulverized to a thickness of less than 45 μm and then soaked in 50-70% ethanol for 2-5 days, with stirring every 8 hours during the soaking period. After soaking, the mixture is centrifuged and filtered to obtain a filtrate and a residue. The ethanol in the filtrate is recovered and evaporated for later use, while the residue is kept for future use. In this invention, the ethanol concentration is preferably 60%, and the soaking time is preferably 3 days.

[0029] In this invention, the Chinese medicinal materials used are preferably pretreated as follows: Chinese yam: remove the root head, wash, remove the outer skin and fibrous roots, slice thickly while fresh, and freeze-dry; Cistanche deserticola: remove the stem tip, slice thickly while fresh, and freeze-dry; Astragalus membranaceus: remove the fibrous roots and root head, scrape off the outer skin, slice thickly while fresh, and freeze-dry; Cinnamon: remove impurities and rough bark, and freeze-dry; Polygonatum sibiricum: remove the fibrous roots, wash, blanch briefly in boiling water or steam until thoroughly cooked, and freeze-dry; Dendrobium officinale: remove impurities, trim some fibrous roots, cut into sections while fresh, and freeze-dry; Ginseng: wash, slice thinly while fresh, and freeze-dry; Kudzu root: remove impurities, wash, cut into thick slices or small pieces while fresh, and freeze-dry; Ziziphus jujuba var. spinosa: remove residual pulp and shell, and freeze-dry. In this invention, the freeze-drying technology is not specifically limited; any freeze-drying technology well-known in the art can be used.

[0030] In this invention, preferably, the mixed freeze-dried medicinal materials are soaked in an appropriate amount of water for 30-60 minutes, then jujube seed residue is added and decocted twice, maintaining a gentle boil. For the first decoction, 6-8 times the amount of water is added, and the decoction is decocted for 1-2 hours. The mixture is then filtered, and the filtrate is collected for later use. For the second decoction, 6-8 times the amount of water is added to the residue, and the mixture is decocted for 1-2 hours. The mixture is then filtered, and the filtrate is collected and combined with the first filtrate. The mixture is allowed to stand for 20-36 hours, centrifuged, filtered, and the ethanol is recovered from the filtrate and evaporated to dryness for later use. More preferably, the mixed freeze-dried medicinal materials are soaked in an appropriate amount of water for 50 minutes, then jujube seed residue is added and decocted twice, maintaining a gentle boil. For the first decoction, 8 times the amount of water is added, and the mixture is decocted for 1.5 hours. The mixture is then filtered, and the filtrate is collected for later use. For the second decoction, 6 times the amount of water is added to the residue, and the mixture is decocted for 1 hour. The mixture is then filtered, and the filtrate is collected and combined with the first filtrate. The mixture is allowed to stand for 24 hours, centrifuged, filtered, and the ethanol is recovered from the filtrate and evaporated to dryness to obtain a evaporated extract for later use.

[0031] In this invention, the above-mentioned rotary-dried extract and rotary-dried jujube seed extract are combined, and a suitable amount of 50-70% ethanol solution is added for redissolution. The mixture is stirred thoroughly and allowed to stand for 20-36 hours, followed by centrifugation and filtration to obtain the filtrate. 0.5-2% activated carbon is added to the filtrate for decolorization, and the mixture is kept in a water bath at 55-65°C with stirring for 0.5-2 hours before centrifugation and filtration. The ethanol in the centrifuged filtrate is recovered, and the mixture is rotary-dried under reduced pressure. Finally, a base of soy sauce-flavored or strong-flavored baijiu is added, stirred thoroughly, and ultrasonically treated for 25-35 minutes. After standing for 20-36 hours, the mixture is filtered through a 0.45mm microporous membrane to obtain the herbal liqueur. In this invention, the ethanol concentration is preferably 60%, and the standing time is preferably 24 hours. In this invention, 1% activated carbon is preferably added to the filtrate for decolorization, and the mixture is kept in a water bath at 60°C with stirring for 1 hour before centrifugation and filtration. In this invention, the ultrasonic treatment time is preferably 30 minutes.

[0032] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0033] Example 1

[0034] A traditional Chinese medicine liquor for nourishing kidney yang and improving sleep, the ingredients include the following raw materials by weight: 20g of Cistanche deserticola, 40g of Ziziphus jujuba var. spinosa, 15g of Dioscorea opposita, 15g of Polygonatum sibiricum, 5g of ginseng, 15g of Astragalus membranaceus, 5g of Dendrobium officinale, 10g of Pueraria lobata, and 5g of Cinnamomum cassia; the base is a strong-aroma or soy sauce-aroma type of baijiu.

[0035] Example 2

[0036] A traditional Chinese medicine liquor that nourishes kidney yang and improves sleep, using the following ingredients by weight: 10g of Cistanche deserticola, 20g of Ziziphus jujuba var. spinosa, 8g of Dioscorea opposita, 8g of Polygonatum sibiricum, 2g of ginseng, 8g of Astragalus membranaceus, 2g of Dendrobium officinale, 5g of Pueraria lobata, and 2g of Cinnamomum cassia; with strong-aroma or soy sauce-aroma baijiu as the base.

[0037] Example 3

[0038] A traditional Chinese medicine liquor for nourishing kidney yang and improving sleep, the ingredients include the following raw materials by weight: 30g of Cistanche deserticola, 50g of Ziziphus jujuba var. spinosa, 25g of Dioscorea opposita, 25g of Polygonatum sibiricum, 8g of ginseng, 25g of Astragalus membranaceus, 8g of Dendrobium officinale, 20g of Pueraria lobata, and 8g of Cinnamomum cassia; the base is a strong-aroma or soy sauce-aroma type of baijiu.

[0039] Example 4

[0040] A method for preparing a traditional Chinese medicine liqueur that nourishes kidney yang and improves sleep includes the following steps:

[0041] (1) Weigh each component according to the weight of each component in the Chinese herbal liquor formula of Examples 1 to 3. All medicinal materials are sliced ​​or segmented while fresh and then freeze-dried and pulverized to below 45μm. Except for jujube seed, the other medicinal materials are placed in a mixing container and mixed evenly. The freeze-drying process specifically includes: For yam, the root head is cut off, washed, the outer skin and fibrous roots are removed, and it is sliced ​​into thick slices while fresh and then freeze-dried; for cistanche, the stem tip is removed, and it is sliced ​​into thick slices while fresh and then freeze-dried; for astragalus, the fibrous roots and root head are removed, the outer skin is scraped off, and it is sliced ​​into thick slices while fresh and then freeze-dried; for cinnamon, impurities and rough bark are removed, and it is freeze-dried; for polygonatum, the fibrous roots are removed, washed, and briefly blanched in boiling water or steamed until thoroughly cooked, and then freeze-dried; for dendrobium, impurities are removed, some fibrous roots are trimmed, and it is cut into sections while fresh and then freeze-dried; for ginseng, it is washed, sliced ​​into thin slices while fresh, and then freeze-dried; for kudzu root, impurities are removed, washed, and cut into thick slices or small pieces while fresh, and then freeze-dried; and for jujube seed, residual pulp and shell are removed, and then freeze-dried.

[0042] (2) Jujube seed soaking: Add the weighed jujube seeds to the soaking container, add an appropriate amount of 60% ethanol and soak for 3 days, stirring once every 8 hours, centrifuge and filter, and keep the residue for later use; recover the ethanol from the soaking liquid and evaporate it for later use.

[0043] (3) Extraction of medicinal materials:

[0044] Soak the remaining freeze-dried medicinal materials in an appropriate amount of water for 30-60 minutes. Add the jujube seed residue and decoct twice, keeping it at a gentle boil. For the first decoction, add 8 times the amount of water and decoct for 1.5 hours. Filter and collect the filtrate for later use. For the second decoction, add 6 times the amount of water and decoct for 1 hour. Filter and collect the filtrate. Combine the filtrate with the first filtrate, let stand for 24 hours, centrifuge and filter, recover the ethanol from the filtrate and evaporate to dryness for later use.

[0045] (4) Reconstitution, rotary evaporation, and decolorization: Combine the extracts after rotary evaporation, add an appropriate amount of 60% ethanol solution for reconstitution, stir thoroughly, let stand for 24 hours, and centrifuge and filter. Add 1% activated carbon to the centrifuged filtrate for decolorization, keep in a 60°C water bath with stirring for 1 hour, and then centrifuge and filter. Recover the ethanol from the centrifuged filtrate and evaporate under reduced pressure.

[0046] (5) Preparation: Add the base of soy sauce aroma or strong aroma baijiu, stir thoroughly, sonicate for 30 minutes, and let stand for 24 hours.

[0047] (6) Filtration: Filtration is performed using a 0.45 microporous membrane to obtain Chinese herbal liquor.

[0048] Example 5

[0049] Unlike Example 4, 0.5% activated carbon was added for decolorization treatment.

[0050] Example 6

[0051] Unlike Example 4, 2% activated carbon was added for decolorization.

[0052] Comparative Example 1

[0053] Unlike Example 4, the mixed freeze-dried medicinal materials were soaked in an appropriate amount of 60% ethanol for 30-60 minutes, and then the jujube seed residue was added and decocted twice, maintaining a gentle boil. For the first decoction, 8 times the amount of 60% ethanol was added, and the decoction was decocted for 1.5 hours. The mixture was then filtered, and the filtrate was collected for later use. For the second decoction, 6 times the amount of 60% ethanol was added to the residue, and the mixture was decocted for 1 hour. The mixture was then filtered, and the filtrate was collected and combined with the first filtrate. The mixture was allowed to stand for 24 hours, centrifuged, filtered, and the ethanol was recovered from the filtrate and evaporated to dryness for later use. The remaining steps were the same as in Example 4.

[0054] Comparative Example 2

[0055] Unlike Example 4, the other weighed medicinal materials were subjected to ordinary drying treatment at 60°C: the root head of the yam was cut off, washed, the outer skin and fibrous roots were removed, and it was cut into thick slices while fresh and dried; the stem tip of the Cistanche deserticola was removed, and it was cut into thick slices while fresh and dried; the fibrous roots and root head of the Astragalus membranaceus were removed, the outer skin was scraped off, and it was cut into thick slices while fresh and dried; the impurities and rough bark of the cinnamon were removed, and it was dried; the fibrous roots of the Polygonatum sibiricum were removed, washed, and briefly blanched in boiling water or steamed until thoroughly cooked, and dried; the impurities of the Dendrobium officinale were removed, some of the fibrous roots were cut off, and it was cut into sections while fresh and dried; the ginseng was washed, cut into thin slices while fresh, and dried; the impurities of the kudzu root were removed, washed, and cut into thick slices or small pieces while fresh and dried; the residual pulp and shell of the Ziziphus jujuba var. spinosa were removed and dried.

[0056] The dried jujube seeds were soaked in the same way as in Example 4.

[0057] The remaining dried medicinal materials after mixing are then processed, and the remaining steps are the same as in Example 4.

[0058] Comparative Example 3

[0059] Unlike Example 4, the other weighed medicinal materials were subjected to ordinary drying treatment at 60°C: the root head of the yam was cut off, washed, the outer skin and fibrous roots were removed, and it was cut into thick slices while fresh and dried; the stem tip of the Cistanche deserticola was removed, and it was cut into thick slices while fresh and dried; the fibrous roots and root head of the Astragalus membranaceus were removed, the outer skin was scraped off, and it was cut into thick slices while fresh and dried; the impurities and rough bark of the cinnamon were removed, and it was dried; the fibrous roots of the Polygonatum sibiricum were removed, washed, and briefly blanched in boiling water or steamed until thoroughly cooked, and dried; the impurities of the Dendrobium officinale were removed, some of the fibrous roots were cut off, and it was cut into sections while fresh and dried; the ginseng was washed, cut into thin slices while fresh, and dried; the impurities of the kudzu root were removed, washed, and cut into thick slices or small pieces while fresh and dried; the residual pulp and shell of the Ziziphus jujuba var. spinosa were removed and dried.

[0060] The dried jujube seeds were extracted using the same method as in Example 4.

[0061] Soak the remaining dried medicinal materials in an appropriate amount of 60% ethanol for 30-60 minutes. Add the jujube seed residue and decoct twice, keeping it at a gentle boil. For the first decoction, add 8 times the amount of 60% ethanol and decoct for 1.5 hours. Filter and collect the filtrate for later use. For the second decoction, add 6 times the amount of 60% ethanol and decoct for 1 hour. Filter and collect the filtrate. Combine the filtrate with the first filtrate, let stand for 24 hours, centrifuge and filter, recover the ethanol from the filtrate and evaporate to dryness for later use. The remaining steps are the same as in Example 4.

[0062] Comparative Example 4

[0063] Unlike Example 4, no decolorization treatment was performed.

[0064] Comparative Example 5

[0065] Unlike Example 4, 0.5% D296R macroporous resin was added for decolorization treatment.

[0066] Comparative Example 6

[0067] Unlike Example 4, 1% D296R macroporous resin was added for decolorization treatment.

[0068] Comparative Example 7

[0069] Unlike Example 4, 2% D296R macroporous resin was added for decolorization treatment.

[0070] Experimental Example 1: Study on the effects of different pretreatment processes in preparing liqueur on tonifying kidney yang and improving sleep.

[0071] Kidney yang deficiency can cause symptoms such as lethargy, fatigue, and insomnia. This study investigated the effects of different pretreatment processes on tonifying kidney yang and improving mental vitality by using a weighted swimming time study in mice. The study also investigated the effects of different pretreatment processes on improving sleep by using the effects of threshold dose sodium pentobarbital on sleep time and sleep incidence in mice.

[0072] 1. Test Methods

[0073] Preparation method: Using soy sauce-flavored baijiu as the base, extracts of various medicinal and edible Chinese herbs are added and blended to make liqueur.

[0074] The formulas and processing methods for medicinal and edible herbs are as follows:

[0075] 1.1 Formulas of Chinese medicinal herbs that can be used as both food and medicine

[0076] Prepare 500ml of the following ingredients: 20g of Cistanche deserticola, 40g of Ziziphus jujuba var. spinosa, 15g of Dioscorea opposita, 15g of Polygonatum sibiricum, 5g of Panax ginseng, 15g of Astragalus membranaceus, 5g of Dendrobium officinale, 10g of Pueraria lobata, and 5g of Cinnamomum cassia.

[0077] 1.2 Investigation on the processing methods of Chinese medicinal herbs that can be used as both food and medicine

[0078] Sour jujube seed was extracted using 60% ethanol followed by water extraction. The other medicinal materials were examined using two different processing methods and two different extraction solvents, as detailed below:

[0079] 1.2.1 Processing method for jujube seeds: Jujube seeds that have undergone freeze-drying / oven drying are pulverized to below 45μm through cell wall breaking → soaked in 60% ethanol for 3 days, stirring every 8 hours → centrifuged and filtered → the ethanol in the filtrate is recovered and evaporated for later use, and the residue is reserved for later use. Specifically, the freeze-drying process involves removing residual pulp and shells from the jujube seeds and then freeze-drying them. The oven-drying process involves removing residual pulp and shells from the jujube seeds and then drying them.

[0080] 1.2.2 Processing methods for other medicinal materials

[0081] (1) All other medicinal materials are freeze-dried:

[0082] ① Cut off the root of the yam, wash it, remove the outer skin and fibrous roots, cut it into thick slices while it is still fresh, and freeze-dry it;

[0083] ② Remove the stem tips from Cistanche deserticola, slice it into thick pieces while it is still fresh, and freeze-dry it;

[0084] ③ Remove the fibrous roots and root head of Astragalus membranaceus, scrape off the outer skin, cut into thick slices while fresh, and freeze-dry.

[0085] ④ Remove impurities and rough bark from the cinnamon and freeze-dry it;

[0086] ⑤ Remove the fibrous roots from Polygonatum rhizome, wash it clean, blanch it briefly in boiling water or steam it until thoroughly cooked, and then freeze-dry it.

[0087] ⑥ Remove impurities from Dendrobium officinale, trim some of the fibrous roots, cut into sections while fresh, and freeze-dry.

[0088] ⑦ Wash the ginseng, slice it thinly while it is still fresh, and freeze-dry it;

[0089] ⑧ Remove impurities from kudzu root, wash it, cut it into thick slices or small pieces while it is still fresh, and freeze-dry it;

[0090] (2) All other medicinal materials are dried using conventional drying techniques:

[0091] ① Cut off the root of the yam, wash it, remove the outer skin and fibrous roots, cut it into thick slices while it is still fresh, and then dry it;

[0092] ② Remove the stem tips from Cistanche deserticola, slice it into thick pieces while it is still fresh, and then dry it;

[0093] ③ Remove the fibrous roots and root head of Astragalus membranaceus, scrape off the outer skin, cut into thick slices while fresh, and then dry.

[0094] ④ Remove impurities and rough bark from the cinnamon and dry it;

[0095] ⑤ Remove the fibrous roots from Polygonatum rhizome, wash it clean, blanch it briefly in boiling water or steam it until thoroughly cooked, and then dry it.

[0096] ⑥ Remove impurities from Dendrobium officinale, trim some of the fibrous roots, cut it into sections while it is still fresh, and then dry it.

[0097] ⑦ Wash the ginseng, slice it thinly while it's still fresh, and then dry it;

[0098] ⑧ Remove impurities from kudzu root, wash it, cut it into thick slices or small pieces while it is still fresh, and then dry it.

[0099] 1.2.3 Specific operations:

[0100] (1) Weighing of medicinal materials: Weigh according to the weight of each component in the liqueur formula. Weigh two portions of each medicinal material using freeze-drying and drying techniques respectively, for a total of four portions. Break the cell wall and crush to below 45μm. Except for jujube seed, the other medicinal materials are placed in a mixing container and mixed evenly.

[0101] (2) Jujube seed soaking: Add the treated jujube seeds to the soaking container, add an appropriate amount of 60% ethanol and soak for 3 days, stirring once every 8 hours, centrifuge and filter, and keep the residue for later use; recover the ethanol from the soaking liquid and evaporate it for later use.

[0102] (3) Extraction from other medicinal materials:

[0103] ① Soak the remaining freeze-dried medicinal materials in an appropriate amount of water for 30-60 minutes. Add the jujube seed residue and decoct twice, keeping it at a gentle boil. For the first decoction, add 8 times the amount of water and decoct for 1.5 hours. Filter and collect the filtrate for later use. For the second decoction, add 6 times the amount of water and decoct for 1 hour. Filter and collect the filtrate. Combine the filtrate with the first filtrate, let it stand for 24 hours, centrifuge and filter. Recover the ethanol from the filtrate and evaporate it to dryness for later use.

[0104] ② Soak the remaining freeze-dried medicinal materials in an appropriate amount of 60% ethanol for 30-60 minutes. Add the jujube seed residue and decoct twice, keeping it at a gentle boil. For the first decoction, add 8 times the amount of 60% ethanol and decoct for 1.5 hours. Filter and collect the filtrate for later use. For the second decoction, add 6 times the amount of 60% ethanol and decoct for 1 hour. Filter and collect the filtrate. Combine the filtrate with the first filtrate, let it stand for 24 hours, centrifuge and filter. Recover the ethanol from the filtrate and evaporate to dryness for later use.

[0105] ③ Soak the remaining dried medicinal materials in an appropriate amount of water for 30-60 minutes. Add the jujube seed residue and decoct twice, keeping it at a gentle boil. For the first decoction, add 8 times the amount of water and decoct for 1.5 hours. Filter and collect the filtrate for later use. For the second decoction, add 6 times the amount of water and decoct for 1 hour. Filter and collect the filtrate. Combine the filtrate with the first filtrate, let it stand for 24 hours, centrifuge and filter, recover the ethanol from the filtrate and evaporate to dryness for later use.

[0106] ④ Soak the remaining dried medicinal materials in an appropriate amount of 60% ethanol for 30-60 minutes. Add the jujube seed residue and decoct twice, keeping it at a gentle boil. For the first decoction, add 8 times the amount of 60% ethanol and decoct for 1.5 hours. Filter and collect the filtrate for later use. For the second decoction, add 6 times the amount of 60% ethanol and decoct for 1 hour. Filter and collect the filtrate. Combine the filtrate with the first filtrate, let it stand for 24 hours, centrifuge and filter. Recover the ethanol from the filtrate and evaporate it to dryness for later use.

[0107] (4) Reconstitution and rotary evaporation: Combine the extracts after rotary evaporation, add an appropriate amount of 60% ethanol solution to reconstitute, stir thoroughly, let stand for 24 hours, and then centrifuge and filter. Recover the ethanol from the centrifuged filtrate and evaporate it under reduced pressure.

[0108] (5) Preparation: Add the base of sauce-flavored liquor, stir thoroughly, sonicate for 30 minutes, and let stand for 24 hours.

[0109] (6) Filtration: Filtrate using a 0.45 microporous membrane to obtain the finished liqueur.

[0110] 2. Research on the effects of different pretreatment processes on nourishing kidney yang and improving sleep in prepared liquors

[0111] (1) Study on the effects of different pretreatment processes on the kidney-tonifying effects of liqueur prepared by different pretreatment processes

[0112] Fifty healthy male ICR mice were acclimatized in an SPF-grade animal facility for 7 days, allowing them to eat and drink independently. After acclimatization, they were randomly divided into 5 groups of 10 mice each. Each group was administered medication by gavage at a volume of 0.2 ml / 10 g. The treatment groups received liqueurs prepared from freeze-dried water extract, freeze-dried alcohol extract, dried water extract, and dried alcohol extract, respectively. The control group received the original alcohol base. The administration continued for 15 days. Thirty minutes after the last administration, the mice were placed in a swimming tank with a water depth of 30 cm and a water temperature of (25±1)℃. A wire weighing 5% of the mouse's body weight was loaded onto the base of the mouse's tail. The time from the start of swimming to death was recorded as the weight-bearing swimming time.

[0113] (2) Effects of different pretreatment processes on sleep duration induced by threshold dose of sodium pentobarbital in mice

[0114] Fifty healthy male ICR mice were acclimatized in an SPF-grade animal facility for 7 days, allowing them to eat and drink independently. After acclimatization, they were randomly divided into 5 groups of 10 mice each. A preliminary experiment was conducted before the formal experiment to determine the optimal dose of pentobarbital sodium (45 mg / kg BW) to induce brief sleep in all mice. The mice in the 5 groups were administered the drug via gavage at a volume of 0.2 ml / 10 g. The treatment groups received liqueurs prepared from freeze-dried water extract, freeze-dried alcohol extract, dried water extract, and dried alcohol extract, respectively. The control group received the original alcohol base. This administration continued for 15 days. Thirty minutes after the last administration, each group received an intraperitoneal injection of pentobarbital sodium (45 mg / kg) at a volume of 0.1 ml / 10 g. The mice were then placed abdomen-up in cages heated by an electric blanket (approximately 37°C). Sleep duration (duration of loss of righting reflex) and sleep latency (latency of loss of righting reflex) were recorded. Criteria for judging the righting reflex: Immediately after the first righting, place the object back in the reverse position. If it does not automatically turn right over within 20 seconds, the righting reflex disappears, then it is a righting reflex.

[0115] (3) Effects of different pretreatment processes on the incidence of sleep induced by subthreshold doses of sodium pentobarbital in mice.

[0116] Fifty healthy male ICR mice were acclimatized in an SPF-grade animal facility for 7 days, after which they were randomly divided into 5 groups of 10 mice each. A preliminary experiment was conducted before the formal experiment to ensure that 80-90% of the mice still exhibited the righting reflex; at this point, the maximum subthreshold dose of sodium pentobarbital was 28 mg / kg BW. The mice in the 5 groups were administered the drug via gavage at a volume of 0.2 ml / 10 g. The drug-treated groups were given liqueurs prepared from lyophilized water extract, lyophilized alcohol extract, dried water extract, and dried alcohol extract, respectively, while the control group received the original alcohol base. This administration continued for 15 days. Thirty minutes after the last administration, each group received an intraperitoneal injection of sodium pentobarbital (28 mg / kg) at a volume of 0.1 ml / 10 g. The criterion for sleep was the disappearance of the righting reflex for more than 1 minute. The number of mice falling asleep within 30 minutes was recorded for each group.

[0117] 3. Experimental Results

[0118] (1) The effect of different pretreatment processes on the weight-bearing swimming time of mice is shown in Table 1. The experimental results show that, compared with the blank control group, the freeze-dried water extraction group and the oven-dried water extraction group can significantly prolong the weight-bearing swimming time of mice compared with the other two alcohol extraction groups, and the freeze-dried water extraction group prolongs the weight-bearing swimming time of mice even longer.

[0119] Table 1. Effects on weight-bearing swimming time in mice ( n=10)

[0120]

[0121] Note: **p<0.01 compared with the blank control group.

[0122] (2) The effects of different pretreatment processes on the sleep time induced by threshold dose of sodium pentobarbital in mice were shown in Table 2. The results showed that, compared with the blank control group, the freeze-dried water extract group and the oven-dried water extract group significantly shortened the sleep latency and prolonged the sleep time of mice compared with the other two alcohol extract groups, and the freeze-dried water extract group had a better effect on shortening the sleep latency and prolonging the sleep time of mice.

[0123] Table 2. Effects of threshold-dose sodium pentobarbital on sleep duration in mice ( n=10)

[0124]

[0125] Note: Compared with the blank control group, *P<0.05, **p<0.01.

[0126] (3) The effect of different pretreatment processes on the incidence of sleep induced by subthreshold doses of sodium pentobarbital in mice was shown in Table 3. The results showed that, compared with the blank control group, the freeze-dried water extract group and the oven-dried water extract group significantly increased the incidence of sleep in mice compared with the other two alcohol extract groups, and the freeze-dried water extract group had a better effect on increasing the incidence of sleep in mice.

[0127] Table 3. Effects of subthreshold doses of sodium pentobarbital on the incidence of sleep in mice. n=10)

[0128]

[0129] Note: Compared with the blank control group, *P<0.05, **P<0.01

[0130] Based on the above experimental results, the traditional Chinese medicine liqueur prepared by freeze-drying and water extraction in this invention is more effective in nourishing kidney yang and improving sleep.

[0131] Experimental Example 2: Study on the properties of traditional Chinese medicine liqueur under different decolorization processes

[0132] The untreated liqueur was still quite dark in color. To make the color of the liqueur closer to that of the base liquor, further decolorization was performed. The study used liqueur color, decolorization rate, and loss rate of jujube seed saponin A as indicators, employing activated carbon and D296R macroporous resin for decolorization. Specifically:

[0133] 1. Calculation of decolorization rate

[0134] (1) Detection of absorption peak of liqueur. The liqueur was scanned in the whole band with the following parameters: wavelength interval 1.0 nm, wavelength range 190.0~1100 nm. The results showed that there was an absorption peak at wavelength 378 nm, so this wavelength was used as the detection wavelength.

[0135] (2) Decolorization rate formula

[0136] Decolorization rate = (Absorbance before decolorization - Absorbance after decolorization) / Absorbance before decolorization × 100%

[0137] 2. Calculation of the loss rate of jujube seed saponin A

[0138] Method for determining the content of jujube seed saponin A in liqueur:

[0139] Take 10 ml of the decolorized liquor, accurately measure it, add dilute ethanol to a final volume of 25 ml, shake well, filter, and collect the filtrate to obtain the test solution. Referring to the chromatographic conditions and system suitability test method for "Jujube Seed Saponin A" under the Jujube Seed section of the 2020 edition of the Chinese Pharmacopoeia, accurately pipette 10 μL of 0.05 mg / ml jujube seed saponin A reference solution and 10 μL of the test solution, inject them into the liquid chromatograph, determine the content of jujube seed saponin A in the liquor using the external standard two-point logarithmic equation.

[0140] Calculate the loss rate of jujube seed saponin A using the following formula.

[0141] Loss rate of jujube seed saponin A = (content before decolorization - content after decolorization) / content before decolorization × 100%

[0142] 3. Decolorization experiment

[0143] Ingredients: 20g Cistanche deserticola, 40g Ziziphus jujuba var. spinosa, 15g Dioscorea opposita, 15g Polygonatum sibiricum, 5g Ginseng, 15g Astragalus membranaceus, 5g Dendrobium officinale, 10g Pueraria lobata, 5g Cinnamomum cassia.

[0144] The jujube seed is pulverized to a size of less than 45μm by breaking down the cell wall → it is soaked in 60% ethanol for 3 days, stirring once every 8 hours → centrifuged and filtered → the ethanol in the filtrate is recovered and evaporated for later use, and the residue is kept for later use.

[0145] The remaining medicinal materials (except for jujube seed) are sliced ​​or segmented while fresh → freeze-dried → pulverized to below 45μm → decocted twice (adding jujube seed residue, first decocting with 8 times the amount of water for 1.5 hours, second decocting with 6 times the amount of water for 1 hour) → allowed to stand → centrifuged and filtered → the supernatant is evaporated → combined with the evaporated jujube seed residue, redissolved in 60% ethanol solution → centrifuged and filtered → decolorized, adding decolorizing agent, kept in a 60℃ water bath and stirred for 1 hour → centrifuged and filtered → the ethanol is recovered and evaporated → preparation, adding soy sauce aroma or strong aroma baijiu base → ultrasonic treatment for 30 minutes → filtered through a 0.45μm microporous membrane → 500ml of traditional Chinese medicine liqueur is obtained.

[0146] 4. Results of the decolorization experiment

[0147] The liqueur treated with different types and amounts of decolorizing agents showed varying degrees of change in color, decolorization rate, and loss rate of jujube seed saponin A. The results of activated carbon decolorization showed that as the amount of activated carbon increased, the finished product color became lighter and the decolorization rate increased, but the loss rate of jujube seed saponin A also increased significantly. Therefore, the optimal amount of activated carbon is 1.0% (see...). Figure 1The decolorization results of D296R macroporous resin showed that the color did not improve with increasing dosage, and the decolorization rate was significantly lower than that of activated carbon. Furthermore, the loss rate of jujube seed saponin A increased with increasing dosage. Comparing the decolorization results of 1.0% activated carbon and 1.0% D296R macroporous resin, 1.0% activated carbon showed better decolorization effect. The finished liquor was clear and transparent, with a light color similar to the base liquor, a high decolorization rate, and a relatively low loss rate of jujube seed saponin A. Therefore, 1.0% activated carbon was ultimately chosen for decolorization treatment.

[0148] Table 4 Comparison of decolorization effects of different decolorization processes

[0149]

[0150] Experimental Example 3: Study on the effects of different decolorization processes on the tonifying effect of traditional Chinese medicine liqueur on kidney yang and sleep improvement.

[0151] 1. Research on the effect of decolorization process on nourishing kidney yang

[0152] Thirty healthy male ICR mice were acclimatized in an SPF-grade animal facility for 7 days, after which they were randomly divided into three groups of 30 mice each. Each group was administered medication by gavage at a volume of 0.2 ml / 10 g. The treatment groups were given liqueur prepared using activated charcoal decolorization and the undecolorized group, respectively, while the control group received the original alcohol base. This treatment continued for 15 days. Thirty minutes after the last administration, the mice were placed in a swimming tank at a depth of 30 cm and a water temperature of (25±1) ℃. A wire weighing 5% of the mouse's body weight was placed on the base of the mouse's tail. The time from the start of swimming to death was recorded as the weight-bearing swimming time.

[0153] 2. Effect of decolorization process on sleep duration induced by threshold dose of sodium pentobarbital in mice

[0154] Thirty healthy male ICR mice were acclimatized in an SPF-grade animal facility for 7 days, allowing them to eat and drink independently. After acclimatization, they were randomly divided into three groups of 10 mice each. Each group received a drug via gavage (0.2 ml / 10 g). The treated groups were given liqueur prepared with activated charcoal decolorization, while the untreated group received the original liqueur. This treatment continued for 15 days. Thirty minutes after the last administration, each group received an intraperitoneal injection of sodium pentobarbital (45 mg / kg) at a volume of 0.1 ml / 10 g. The mice were then placed belly-up in cages heated by an electric blanket (approximately 37°C). Sleep time (duration of the righting reflex disappearance) and sleep latency (latency of the righting reflex disappearance) were recorded. The righting reflex was determined by immediately repositioning the mouse back after the first righting; if the mouse did not automatically turn over within 20 seconds, the righting reflex was considered lost.

[0155] 3. Effect of decolorization process on the incidence of sleep induced by subthreshold doses of sodium pentobarbital in mice

[0156] Thirty healthy male ICR mice were acclimatized in an SPF-grade animal facility for 7 days, after which they were randomly divided into three groups of 10 mice each. Each group was administered medication by gavage at a volume of 0.2 ml / 10 g. The treatment groups were given liqueur prepared using activated charcoal decolorization and the undecolorized group, respectively, while the control group received the original alcohol base. This administration continued for 15 days. Thirty minutes after the last administration, each group received an intraperitoneal injection of sodium pentobarbital (28 mg / kg) at a volume of 0.1 ml / 10 g. The criterion for sleep was the disappearance of the righting reflex for more than 1 minute. The number of mice falling asleep within 30 minutes was recorded for each group.

[0157] 4. Experimental Results

[0158] (1) Effect of decolorization process on weight-bearing swimming time of mice. The results are shown in Table 5. The experimental results show that, compared with the blank control group, both the activated carbon decolorization group and the undecolorized group can significantly prolong the weight-bearing swimming time of mice, and the activated carbon decolorization group prolongs the weight-bearing swimming time of mice even longer.

[0159] Table 5. Effects on weight-bearing swimming time in mice ( n=10)

[0160]

[0161] Note: **p<0.01 compared with the blank control group.

[0162] (2) The effect of decolorization process on the sleep time induced by threshold dose of sodium pentobarbital in mice is shown in Table 6. The experimental results show that, compared with the blank control group, both the activated carbon decolorization group and the undecolorized group can significantly shorten the sleep latency and prolong the sleep time of mice. Comparing the results of activated carbon decolorization and undecolorization, the activated carbon decolorization group has a better effect on shortening the sleep latency and prolonging the sleep time of mice.

[0163] Table 6. Effects of threshold-dose sodium pentobarbital on sleep duration in mice ( n=10)

[0164]

[0165] Note: Compared with the blank control group, *P<0.05, **P<0.01

[0166] (3) The effect of decolorization process on the incidence of sleep induced by subthreshold dose of sodium pentobarbital in mice is shown in Table 7. The experimental results showed that, compared with the blank control group, both the activated carbon decolorization group and the non-decolorization group significantly increased the incidence of sleep in mice. Comparing the results of activated carbon decolorization and non-decolorization, the activated carbon decolorization group had a better effect on increasing the incidence of sleep in mice.

[0167] Table 7. Effects of subthreshold doses of sodium pentobarbital on the incidence of sleep in mice. n=10)

[0168]

[0169] Note: Compared with the blank control group, *P<0.05, **P<0.01

[0170] In summary, the herbal liqueur prepared by this invention is clear and transparent with a light color, similar to the original wine base. It fully retains the color, aroma, and flavor of the original wine base and has the effects of nourishing kidney yang and improving sleep quality. It is suitable for people with symptoms of kidney yang deficiency.

[0171] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine liqueur that nourishes kidney yang and improves sleep, characterized in that, Made from the following parts by weight of traditional Chinese medicine raw materials: Cistanche deserticola 10-30 parts, Ziziphus jujuba var. spinosa 20-50 parts, Dioscorea opposita 8-25 parts, Polygonatum sibiricum 8-25 parts, Panax ginseng 2-8 parts, Astragalus membranaceus 8-25 parts, Dendrobium officinale 2-8 parts, Pueraria lobata 5-20 parts, Cinnamomum cassia 2-8 parts; The herbal liqueur uses strong-aroma or sauce-aroma baijiu as its base. The preparation method of the herbal liqueur includes the following steps: After freeze-drying, the jujube seeds are broken down and pulverized, then soaked in 50-70% ethanol to obtain a jujube seed soaking solution; the jujube seed soaking solution is centrifuged and filtered to obtain a jujube seed filtrate and a jujube seed residue; the jujube seed filtrate is then evaporated to obtain a jujube seed evaporated product by recovering the ethanol. The remaining medicinal materials are sliced ​​or cut into sections while fresh, then freeze-dried and pulverized. They are then added to the above-mentioned jujube seed residue, decocted in water, and centrifuged and filtered to obtain the supernatant. The supernatant is then evaporated and combined with the evaporated jujube seed residue. 50-70% ethanol is added for redissolution, and the mixture is centrifuged and filtered to obtain the filtrate. The filtrate is then decolorized, centrifuged and filtered, and the ethanol is recovered and evaporated. A base alcohol is added, and the mixture is ultrasonically treated and filtered through a microporous membrane to obtain the Chinese herbal liquor. The decolorization treatment is performed using 0.5-2% activated carbon in a water bath at 55-65℃ for 0.5-2 hours.

2. A method for preparing a traditional Chinese medicine liqueur as described in claim 1, characterized in that, Includes the following steps: After freeze-drying, the jujube seeds are broken down and pulverized, then soaked in 50-70% ethanol to obtain a jujube seed soaking solution; the jujube seed soaking solution is centrifuged and filtered to obtain a jujube seed filtrate and a jujube seed residue; the jujube seed filtrate is then evaporated to obtain a jujube seed evaporated product by recovering the ethanol. The remaining medicinal materials are sliced ​​or cut into sections while fresh, then freeze-dried and pulverized. They are then added to the above-mentioned jujube seed residue, decocted in water, and centrifuged and filtered to obtain the supernatant. The supernatant is then evaporated and combined with the evaporated jujube seed residue. 50-70% ethanol is added for redissolution, and the mixture is centrifuged and filtered to obtain the filtrate. The filtrate is then decolorized, centrifuged and filtered, and the ethanol is recovered and evaporated. A base alcohol is added, and the mixture is ultrasonically treated and filtered through a microporous membrane to obtain the Chinese herbal liquor. The decolorization treatment is performed using 0.5-2% activated carbon in a water bath at 55-65℃ for 0.5-2 hours.

3. The preparation method according to claim 2, characterized in that, The soaking time is 2 to 5 days.

4. The preparation method according to claim 2, characterized in that, The particle size of the Chinese herbal medicine after cell wall breaking and pulverization is less than 45 μm.

5. The preparation method according to claim 2, characterized in that, The weight ratio of Chinese medicine to water during decoction is 1:6 to 8.

6. The preparation method according to claim 2, characterized in that, The decoction time is 1 to 2 hours per batch.

7. The preparation method according to claim 2, characterized in that, The ultrasonic treatment time is 25 to 35 minutes.

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