A kind of whitening and freckle - reducing composition that turns into water upon application, its preparation method and application

Abstract

The present invention relates to the field of daily chemical technology, and in particular to a wipe-to-water whitening and freckle-reducing composition, its preparation method and application. The composition comprises: a humectant, a skin conditioner, an emollient, an emulsifier, a thickener, a preservative, a stabilizer, a pH regulator, a chelating agent, a fragrance, a plant extract; wherein, the stabilizer comprises a fermented filtrate of soybean milk; the emollient comprises polydimethylsiloxane with a viscosity of 5±0.5 mPa·S; the humectant comprises sodium hyaluronate with a molecular weight of 200,000 to 400,000. The wipe-to-water whitening and freckle-reducing composition provided by the present invention can quickly turn into water when contacting the skin. At the same time, while forming a protective layer on the skin surface, the skin feel is always very moist and there will be no false dryness.

Description

Technical Field

[0001] The present invention relates to the field of daily chemical technology, and in particular to a water-converting whitening and freckle-removing composition by one application, its preparation method and application. Background Art

[0002] With the pursuit of beauty by people and the development of technology, consumers have more and more and higher requirements for skin care products and cosmetics; and they are gradually developing towards the direction of green and healthy.

[0003] Common skin care products include functions such as moisturizing, whitening, freckle-removing, anti-wrinkle, and moisturizing; at the same time, common skin care products produce effects by covering the skin surface and then being absorbed. Since the skin is the first barrier of the human body, good skin care effects will not necessarily be produced after using skin care products.

[0004] At the same time, with the development of technology, people also put forward high requirements for the skin feel of skin care products. For moisturizing products, a better refreshing feeling is expected; for refreshing products, a better persistence is expected; for oil-water mixed products, a stable skin feel is expected.

[0005] In view of the above phenomena, the present invention provides a water-converting whitening and freckle-removing composition by one application, its preparation method and application. Summary of the Invention

[0006] To solve the above technical problems, the present invention provides a water-converting whitening and freckle-removing composition by one application, which composition comprises: a humectant, a skin conditioner, an emollient, an emulsifier, a thickener, a preservative, a stabilizer, a pH regulator, a chelating agent, a fragrance, a plant extract;

[0007] Wherein, the stabilizer comprises a soybean milk fermentation filtrate; the emollient comprises polydimethylsiloxane with a viscosity of 5±0.5 mPa·S; the humectant comprises sodium hyaluronate with a molecular weight of 200,000 to 400,000.

[0008] As an embodiment of the present invention, the emollient comprises octyl polymethylsiloxane, caprylic / capric triglyceride, polydimethylsiloxane and Rosa damascena flower oil.

[0009] As an embodiment of the present invention, the stabilizer comprises butyl polyether-3, sodium benzotriazolyl butylphenol sulfonate and tributyl citrate.

[0010] As an embodiment of the present invention, the stabilizer comprises chitosan acetylamine, ethyl cellulose, propylene glycol isostearate, carbomer, soybean milk fermentation filtrate and acryloyldimethyltaurate / VP copolymer.

[0011] As an embodiment of the present invention, the plant extract comprises gentiana root extract, yeast / acetic acid bacteria / black tea fermentation product, capparis spinosa fruit extract, and paeonia root extract.

[0012] As an embodiment of the present invention, the skin conditioner comprises allantoin, xylitol glucoside, acetyl hexapeptide-8, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, nonapeptide-1, palmitoyl tripeptide-5, α-glucan oligosaccharide, smallanthus sonchifolius root juice, and carnosine.

[0013] As an embodiment of the present invention, by mass, the composition comprises:

[0014] pH regulator: 0.01 - 0.15 parts of sodium hydroxide;

[0015] Chelating agent: 0.01 - 0.2 parts of disodium EDTA;

[0016] Humectant: 0.1 - 10 parts of butylene glycol, 0.1 - 10 parts of propylene glycol, 0.01 - 0.1 parts of sodium hyaluronate;

[0017] Fragrance: 0.01 - 0.1 parts of essence;

[0018] Preservative: 0.1 - 0.3 parts of methylparaben, 0.1 - 0.5 parts of phenoxyethanol;

[0019] Emulsifier: 0.3 parts of propylene glycol laurate;

[0020] Emollient: 0.5 - 2 parts of octyl polymethylsiloxane, 0.1 - 5 parts of caprylic / capric triglyceride, 0.1 - 5 parts of polydimethylsiloxane, 0.001 - 0.1 parts of rosa damascena flower oil;

[0021] Stabilizer: 3 parts of soybean fermentation filtrate, 6.25 parts of butyl polyether-3, 3.25 parts of sodium benzotriazolyl butylphenol sulfonate, 0.5 parts of tributyl citrate;

[0022] Thickener: 0.2 parts of chitosan amine, 0.2 parts of ethyl cellulose, 0.1 parts of propylene glycol isostearate, 0.05 - 0.6 parts of carbomer, 0.01 - 0.5 parts of acryloyldimethyltaurate / VP copolymer;

[0023] Plant extract: 0.01 parts of gentiana scabra root extract, 0.5 parts of yeast / acetic acid bacteria / black tea fermentation product, 0.02 parts of capparis spinosa fruit extract, 0.01 parts of paeonia albiflora root extract;

[0024] Skin conditioner: comprising

[0025] 0.1 - 3 parts of niacinamide;

[0026] 0.2 - 1.5 parts of 1,2 - hexanediol;

[0027] 0.05 - 0.3 parts of allantoin;

[0028] Combination A: betaine, water 0.1 - 3 parts;

[0029] Combination B: xylitol glucoside, anhydroxylitol, water, xylitol, glucose 0.05 - 1.0 part;

[0030] 0.001 - 0.1 part of acetyl hexapeptide - 8;

[0031] Combination C: water, phenoxyethanol, palmitoyl pentapeptide - 4, polysorbate - 20, ethylhexylglycerin, polyacrylic acid, arginine 0.001 - 0.1 part;

[0032] Combination D: water, polysorbate - 20, carbomer, phenoxyethanol, ethylhexylglycerin, palmitoyl tripeptide - 10 0.001 - 0.1 part;

[0033] Combination E: water, 1,2 - hexanediol, nonapeptide - 1 0.001 - 0.1 part;

[0034] Combination F: glycerol, water, palmitoyl tripeptide - 5 0.001 - 0.1 part;

[0035] Combination G: alpha - glucan oligosaccharide, POLYMNIASONCHIFOLIA root juice, maltodextrin, lactobacillus 0.001 - 0.1 part;

[0036] Combination H: carnosine 0.0001 - 0.5 part;

[0037] Solvent: water is supplemented to 100 parts.

[0038] The second aspect of the present invention provides a wipe - on water - type whitening and freckle - lightening lotion, which is prepared from the described wipe - on water - type whitening and freckle - lightening composition.

[0039] The third aspect of the present invention provides a preparation method of the described wipe - on water - type whitening and freckle - lightening lotion as follows:

[0040] S01. Clean and disinfect the production equipment;

[0041] Pretreatment 1: Premix the raw materials of Phase B, stir evenly, and set aside;

[0042] Pretreatment 2: Soak the raw materials of Phase C one day in advance until uniformly transparent, and homogenize evenly with an external homogenizer head;

[0043] S02. Add deionized water of Phase A to the emulsifying pan, heat it to 80 - 85 °C, add the remaining raw materials of Phase A and Phase B in Pretreatment 1, stir and keep warm to dissolve until it becomes clear and transparent (20 - 25 r / min). Then add Phase C in Pretreatment 2, evacuate and homogenize (2000 - 2500 r / min) for 5 - 8 min, and then keep warm for 10 - 15 min;

[0044] S03. Add the raw materials of Phase D to the oil pan, stir and heat up to 80 - 85 °C, dissolve them thoroughly, keep warm for 3 - 5 min and then pump them into the emulsifying pan; After evacuating and homogenizing for 5 - 8 minutes (2000 - 2500 r / min), add the raw materials of Phase E, evacuate and homogenize again for 5 minutes, and then stir and keep warm for 15 minutes (20 - 25 r / min);

[0045] S04. When the temperature drops to 45 °C, add the raw materials of Phase F (the particulate or powder raw materials are added after being dissolved in a small amount of water), and stir evenly (20 - 25 r / min);

[0046] S05. Cool down to 35 - 38 °C, send for inspection. After passing the inspection, filter through a 400 - mesh sieve and discharge the product;

[0047] S06. Fill and package; After passing the inspection, store the finished products in the warehouse;

[0048] Among them:

[0049] Raw materials of Phase A: part of the solvent, propylene glycol, butylene glycol, methylparaben, allantoin, disodium EDTA; Raw materials of Phase B: sodium hyaluronate;

[0050] Raw materials of Phase C: carbomer, the remaining solvent

[0051] Raw materials of Phase D: octyl polymethylsiloxane, caprylic / capric triglyceride, polydimethylsiloxane, propylene glycol laurate, ethyl cellulose, propylene glycol isostearate, acryloyldimethyltaurate / VP copolymer;

[0052] Raw materials of Phase E: sodium hydroxide;

[0053] Raw materials of Phase F: phenoxyethanol, Skin Conditioner Combination B, niacinamide, acetyl hexapeptide - 8, soybean fermentation filtrate, Combination A, essence, butyl polyether - 3, sodium benzotriazolyl butylphenol sulfonate, tributyl citrate, 1,2 - hexanediol, Combination C, carnosine, Combination D, Combination E, Combination F, Combination G, Rosa damascena flower oil, Gentiana scabra root extract, yeast / acetic acid bacteria / black tea fermentation product, Capparis spinosa fruit extract, Paeonia albiflora root extract.

[0054] The fourth aspect of the present invention provides the described whitening and freckle - reducing composition that turns into water upon application, which is used in the field of whitening skin care.

[0055] Adopting the above - mentioned technical solution, the present invention has the following beneficial effects:

[0056] When the whitening and freckle - reducing composition that turns into water upon application provided by the present invention comes into contact with the skin, it can quickly turn into water upon application. At the same time, while forming a protective layer on the skin surface, the skin feel during use is always very moist and there will be no false dryness. BRIEF DESCRIPTION OF THE DRAWINGS

[0057] In order to more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for use in the description of the specific embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0058] Figure 1 : The product of Example 1 Figure 1 (Just applied)

[0059] Figure 2 : The product of Example 1 Figure 2 (2 s after application). DETAILED DESCRIPTION OF THE EMBODIMENTS

[0060] The following will clearly and completely describe the technical solutions of the present invention. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0061] The present invention provides a whitening and freckle - reducing composition that turns into water upon application. By mass, the composition includes:

[0062] pH regulator: 0.05 part of sodium hydroxide;

[0063] Chelating agent: 0.1 part of disodium EDTA;

[0064] Humectant: 2 parts of butanediol, 3.5 parts of propylene glycol, 0.05 part of sodium hyaluronate;

[0065] Fragrance: 0.05 part of essence;

[0066] Preservative: 0.2 part of methylparaben, 0.2 part of phenoxyethanol;

[0067] Emulsifier: 0.3 part of propylene glycol laurate;

[0068] Emollient: Octyl polymethylsiloxane 1.2 parts, Caprylic / capric triglyceride 1.5 parts, Polydimethylsiloxane 2 parts, Rosa damascena flower oil 0.005 parts;

[0069] Stabilizer: Fermented soybean filtrate 3 parts, Butoxypolyethylene-3 6.25 parts, Sodium benzotriazolyl butylphenol sulfonate 3.25 parts, Tributyl citrate 0.5 parts;

[0070] Thickener: Chitosan oligosaccharide 0.2 parts, Ethyl cellulose 0.2 parts, Propylene glycol isostearate 0.1 parts, Carbomer 0.4 parts, Acryloyldimethyltaurate / VP copolymer 0.2 parts;

[0071] Plant extract: Gentiana scabra root extract 0.01 parts, Yeast / Acetobacter xylinum / black tea ferment 0.5 parts, Capparis spinosa fruit extract 0.02 parts, Paeonia albiflora root extract 0.01 parts;

[0072] Skin conditioner: Containing,

[0073] Niacinamide 1.5 parts;

[0074] 1,2-Hexanediol 0.5 parts;

[0075] Allantoin 0.1 parts;

[0076] Combination A: Betaine 1.5 parts, Water 0.1 parts;

[0077] Combination B: Xylitol glucoside, Anhydroxylitol, Water, Xylitol, Glucose 1.0 parts; Xylitol glucoside: Anhydroxylitol: Water: Xylitol: Glucose = 40:28:16:12:4.

[0078] Acetyl hexapeptide-8 0.001 - 0.1 parts;

[0079] Combination C: Water, Phenoxyethanol, Palmitoyl pentapeptide-4, Polysorbate-20, Ethylhexylglycerin, Polyacrylic acid, Arginine 0.1 parts;

[0080] Phenoxyethanol: Palmitoyl pentapeptide-4: Polysorbate-20: Ethylhexylglycerin: Polyacrylic acid: Arginine = 98.16:0.9:0.01:0.75:0.1:0.05:0.03

[0081] Combination D: Water, Polysorbate-20, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Palmitoyl tripeptide-1 0.1 parts;

[0082] Water: Polysorbate-20: Carbomer: Phenoxyethanol: Ethylhexylglycerin: Palmitoyl Tripeptide-1 = 91.285: 4.25: 3.5: 0.9: 0.055: 0.01.

[0083] Composition E: Water, 1,2 - Hexanediol, Nonapeptide-1 0.001 - 0.1 parts; Water: 1,2 - Hexanediol: Nonapeptide-1 = 97.15: 2.75: 0.1.

[0084] Composition F: Glycerin, Water, Palmitoyl Tripeptide-5 0.001 - 0.1 parts; Glycerin: Water: Palmitoyl Tripeptide-5 = 61.95: 37.5: 0.55.

[0085] Composition G: Alpha-Glucan Oligosaccharide, POLYMNIASONCHIFOLIA Root Juice, Maltodextrin, Lactobacillus 0.001 - 0.1 parts; Alpha-Glucan Oligosaccharide: POLYMNIASONCHIFOLIA Root Juice: Maltodextrin: Lactobacillus = 70: 19: 10: 1

[0086] Composition H: Carnosine 0.0001 - 0.5 parts;

[0087] Solvent: Water is supplemented to 100 parts.

[0088] The manufacturer information is as follows in the table.

[0089]

[0090]

[0091]

[0092] In the present invention, the viscosity of the polydimethylsiloxane is 5 ± 0.5 mPa·S, purchased from Fengcheng Huachen New Materials Co., Ltd.; the molecular weight of sodium hyaluronate is 200,000 - 400,000, purchased from Shanghai Macklin Biochemical Co., Ltd.

[0093] In the present invention, the preparation method of the soybean milk fermentation filtrate is as follows:

[0094] (1) After washing the soybeans, soak them in water at room temperature for 12 h, and then grind them according to the ratio of soybeans to distilled water of 1:2 to obtain the crude soybean milk;

[0095] (2) After mixing the crude soybean milk obtained in step (1) with Medium A, add Strain A, and carry out aerobic fermentation at 35 °C for 1 d; then add 3 wt% (3 wt% of Medium A) of beef extract powder, and Strains B and C, and then carry out aerobic fermentation at 30 °C for 3 d;

[0096] (3) Filter the product of step (2) to obtain a fermentation filtrate, and then heat and evaporate it until its mass is the same as that of the soybeans in step (1), thereby obtaining the fermented filtrate of soy milk.

[0097] Among them, the components of the culture medium A are 1000.0 mL of potato juice, 10.0 g of glucose, and 15.0 - 20.0 g of agar.

[0098] The strain A is Bacillus amyloliquefaciens, China Center for Industrial Culture Collection, 20164. The inoculation amount is 1 vol% of the culture medium.

[0099] The strain B is Bacillus subtilis, China Center for Industrial Culture Collection, 24782. The inoculation amount is 3 vol% of the culture medium.

[0100] The strain C is Bacillus subtilis, China Center for Industrial Culture Collection, 22129. The inoculation amount is 2 vol% of the culture medium.

[0101] The mass ratio of the crude soy milk to the culture medium A is 1:5.

[0102] The following further explains the present invention in conjunction with specific embodiments.

[0103] Example 1

[0104] This example provides a skin-whitening and freckle-reducing composition that turns into water upon application. By mass, the composition contains:

[0105] pH regulator: 0.05 part of sodium hydroxide;

[0106] Chelating agent: 0.1 part of disodium EDTA;

[0107] Humectant: 2 parts of butanediol, 3.5 parts of propylene glycol, 0.05 part of sodium hyaluronate;

[0108] Fragrance: 0.05 part of essence;

[0109] Preservative: 0.2 part of methylparaben, 0.2 part of phenoxyethanol;

[0110] Emulsifier: 0.3 part of propylene glycol laurate;

[0111] Emollient: Octyl polymethylsiloxane 1.2 parts, Caprylic / Capric Triglyceride 1.5 parts, Polydimethylsiloxane 2 parts, Rosa damascena flower oil 0.005 parts;

[0112] Stabilizer: Fermented soybean filtrate 3 parts, Butyl polyether-3 6.25 parts, Sodium benzotriazolyl butylphenol sulfonate 3.25 parts, Tributyl citrate 0.5 parts;

[0113] Thickener: Chitosan oligosaccharide 0.2 parts, Ethyl cellulose 0.2 parts, Propylene glycol isostearate 0.1 parts, Carbomer 0.4 parts, Acryloyldimethyltaurate / VP copolymer 0.2 parts;

[0114] Plant extract: Gentiana scabra root extract 0.01 parts, Yeast / Acetobacter xylinum / Black tea ferment 0.5 parts, Capparis spinosa fruit extract 0.02 parts, Paeonia albiflora root extract 0.01 parts;

[0115] Skin conditioner: Containing,

[0116] Niacinamide 1.5 parts;

[0117] 1,2-Hexanediol 0.5 parts;

[0118] Allantoin 0.1 parts;

[0119] Combination A: Betaine 1.5 parts, Water 0.1 parts;

[0120] Combination B: Xylitylglucoside, Anhydroxylitol, Water, Xylitol, Glucose 1.0 parts; Xylitylglucoside:Anhydroxylitol:Water:Xylitol:Glucose = 40:28:16:12:4.

[0121] Acetyl hexapeptide-8 0.001 - 0.1 parts;

[0122] Combination C: Water, Phenoxyethanol, Palmitoyl pentapeptide-4, Polysorbate-20, Ethylhexylglycerin, Polyacrylic acid, Arginine 0.1 parts;

[0123] Phenoxyethanol:Palmitoyl pentapeptide-4:Polysorbate-20:Ethylhexylglycerin:Polyacrylic acid:Arginine = 98.16:0.9:0.01:0.75:0.1:0.05:0.03

[0124] Combination D: Water, Polysorbate-20, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Palmitoyl tripeptide-1 0.1 parts;

[0125] Water: Polysorbate-20: Carbomer: Phenoxyethanol: Ethylhexylglycerin: Palmitoyl Tripeptide-1 = 91.285: 4.25: 3.5: 0.9: 0.055: 0.01.

[0126] Composition E: Water, 1,2 - Hexanediol, Nonapeptide-1 0.001 - 0.1 parts; Water: 1,2 - Hexanediol: Nonapeptide-1 = 97.15: 2.75: 0.1.

[0127] Composition F: Glycerin, Water, Palmitoyl Tripeptide-5 0.001 - 0.1 parts; Glycerin: Water: Palmitoyl Tripeptide-5 = 61.95: 37.5: 0.55.

[0128] Composition G: Alpha-Glucan Oligosaccharide, Polymnia sonchifolia Root Juice, Maltodextrin, Lactobacillus 0.001 - 0.1 parts; Alpha-Glucan Oligosaccharide: Polymnia sonchifolia Root Juice: Maltodextrin: Lactobacillus = 70: 19: 10: 1

[0129] Composition H: Carnosine 0.0001 - 0.5 parts;

[0130] Solvent: Water is supplemented to 100 parts.

[0131] The molecular weight of sodium hyaluronate is 200,000 - 400,000, and the viscosity of the polydimethylsiloxane is 5 ± 0.5 mPa·S (25 °C), purchased from Huachen New Materials Co., Ltd., Fengcheng City.

[0132] The preparation method of the soybean milk fermentation filtrate is as follows:

[0133] (4) After washing the soybeans, soak them in water at room temperature for 12 h, and then grind them according to the ratio of soybeans to distilled water of 1:2 to obtain the crude soybean milk;

[0134] (5) After mixing the crude soybean milk obtained in step (1) with Medium A, add Strain A, and perform aerobic fermentation at 35 °C for 1 d; add 3 wt% (3 wt% of Medium A) of beef extract powder, and Strains B and C, and then perform aerobic fermentation at 30 °C for 3 d;

[0135] (6) Filter the product obtained in step (2) to obtain the fermentation filtrate, and then heat and evaporate until the mass is the same as the mass of the soybeans in step (1), and the soybean milk fermentation filtrate can be obtained.

[0136] Among them, the components of Medium A are 1000.0 mL of potato juice, 10.0 g of glucose, and 15.0 - 20.0 g of agar.

[0137] The strain A is Bacillus amyloliquefaciens, China Center for Industrial Culture Collection, 20164. The inoculation amount is 1 vol% of the culture medium.

[0138] The strain B is Bacillus subtilis, China Center for Industrial Culture Collection, 24782. The inoculation amount is 3 vol% of the culture medium.

[0139] The strain C is Bacillus subtilis, China Center for Industrial Culture Collection, 22129. The inoculation amount is 2 vol% of the culture medium.

[0140] The mass ratio of the crude soymilk to the culture medium A is 1:5.

[0141] The preparation method of a kind of one-smear water whitening and freckle-reducing lotion is as follows:

[0142] S01. Clean and disinfect the production equipment;

[0143] Pretreatment 1: Premix the phase B raw materials, stir evenly, and set aside;

[0144] Pretreatment 2: Soak the phase C raw materials one day in advance until uniformly transparent, and homogenize evenly with an external homogenizer head;

[0145] S02. Add the deionized water of phase A to the emulsifying pot, heat to 80 - 85 °C, add the remaining raw materials of phase A and phase B in the pretreatment 1, stir and keep warm to dissolve until clear and transparent (20 - 25 r / min), then add phase C in the pretreatment 2, vacuum homogenize (2000 - 2500 r / min) for 5 - 8 min, and then keep warm for 10 - 15 min;

[0146] S03. Add the phase D raw materials to the oil pot, stir and heat up to 80 - 85 °C, fully dissolve and mix evenly, keep warm for 3 - 5 min and then pump into the emulsifying pot; After vacuum homogenizing for 5 - 8 minutes (2000 - 2500 r / min), add the phase E raw materials, vacuum homogenize again for 5 minutes, and then stir and keep warm for 15 minutes (20 - 25 r / min);

[0147] S04. When the temperature drops to 45 °C, add the phase F raw materials (the granular or powder raw materials are dissolved in a small amount of water and then added), and stir evenly (20 - 25 r / min);

[0148] S05. Cool down to 35 - 38 °C, send for inspection, and after passing the inspection, filter and discharge with a 400 - mesh filter;

[0149] S06. Filling and packaging; after passing the inspection, the finished products are warehoused;

[0150] Among them:

[0151] Raw materials of Phase A: part of the solvent, propylene glycol, butylene glycol, methylparaben, allantoin, disodium EDTA;

[0152] Raw materials of Phase B: sodium hyaluronate;

[0153] Raw materials of Phase C: carbomer, the remaining solvent

[0154] Raw materials of Phase D: octyl polymethylsiloxane, caprylic / capric triglyceride, polydimethylsiloxane, propylene glycol laurate, ethyl cellulose, propylene glycol isostearate, acryloyldimethyltaurate / VP copolymer;

[0155] Raw materials of Phase E: sodium hydroxide;

[0156] Raw materials of Phase F: phenoxyethanol, Skin Conditioner Combination B, niacinamide, acetyl hexapeptide-8, soybean fermentation filtrate, Combination A, essence, butylene glycol polyether-3, sodium benzotriazolyl butylphenol sulfonate, tributyl citrate, 1,2-hexanediol, Combination C, carnosine, Combination D, Combination E, Combination F, Combination G, Rosa damascena flower oil, Gentiana scabra root extract, yeast / acetic acid bacterium / black tea fermentation product, Capparis spinosa fruit extract, Paeonia albiflora root extract.

[0157] Example 2-1

[0158] The difference from Example 1 is that this example provides a wipe-on water-whitening and freckle-reducing composition, and according to parts by mass, the composition contains:

[0159] pH regulator: 0.05 part of sodium hydroxide;

[0160] Chelating agent: 0.1 part of disodium EDTA;

[0161] Humectant: 2 parts of butylene glycol, 3.5 parts of propylene glycol, 0.05 part of sodium hyaluronate;

[0162] Fragrance: 0.05 part of essence;

[0163] Preservative: 0.2 part of methylparaben, 0.2 part of phenoxyethanol;

[0164] Emulsifier: 0.3 part of propylene glycol laurate;

[0165] Emollient: 1.2 parts of octyl polymethylsiloxane, 1.5 parts of caprylic / capric triglyceride, 2 parts of polydimethylsiloxane, 0.005 parts of Rosa damascena flower oil;

[0166] Stabilizer: 3 parts of subtilisin, 6.25 parts of butyl polyether-3, 3.25 parts of sodium benzotriazolyl butylphenol sulfonate, 0.5 parts of tributyl citrate;

[0167] Thickener: 0.2 parts of chitosan amine, 0.2 parts of ethyl cellulose, 0.1 parts of propylene glycol isostearate, 0.4 parts of carbomer, 0.2 parts of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer;

[0168] Plant extract: 0.01 parts of Gentiana scabra root extract, 0.5 parts of yeast / acetobacter xylinum / black tea fermentation product, 0.02 parts of Capparis spinosa fruit extract, 0.01 parts of Paeonia albiflora root extract;

[0169] Skin conditioner: including,

[0170] 1.5 parts of niacinamide;

[0171] 0.5 parts of 1,2-hexanediol;

[0172] 0.1 parts of allantoin;

[0173] Combination A: 1.5 parts of betaine, 0.1 parts of water;

[0174] Combination B: xylitol glucoside, anhydroxylitol, water, xylitol, glucose 1.0 part; xylitol glucoside: anhydroxylitol: water: xylitol: glucose = 40:28:16:12:4.

[0175] 0.001 - 0.1 parts of acetyl hexapeptide-8;

[0176] Combination C: water, phenoxyethanol, palmitoyl pentapeptide-4, polysorbate-20, ethylhexylglycerol, polyacrylic acid, 0.1 parts of arginine;

[0177] Phenoxyethanol: palmitoyl pentapeptide-4: polysorbate-20: ethylhexylglycerol: polyacrylic acid: arginine = 98.16:0.9:0.01:0.75:0.1:0.05:0.03

[0178] Combination D: water, polysorbate-20, carbomer, phenoxyethanol, ethylhexylglycerol, 0.1 parts of palmitoyl tripeptide-1;

[0179] Water: Polysorbate-20: Carbomer: Phenoxyethanol: Ethylhexylglycerin: Palmitoyl Tripeptide-1 = 91.285: 4.25: 3.5: 0.9: 0.055: 0.01.

[0180] Combination E: Water, 1,2 - Hexanediol, Nonapeptide-1 0.001 - 0.1 parts; Water: 1,2 - Hexanediol: Nonapeptide-1 = 97.15: 2.75: 0.1.

[0181] Combination F: Glycerin, Water, Palmitoyl Tripeptide-5 0.001 - 0.1 parts; Glycerin: Water: Palmitoyl Tripeptide-5 = 61.95: 37.5: 0.55.

[0182] Combination G: Alpha - Glucan Oligosaccharide, Polymnia sonchifolia Root Juice, Maltodextrin, Lactobacillus 0.001 - 0.1 parts; Alpha - Glucan Oligosaccharide: Polymnia sonchifolia Root Juice: Maltodextrin: Lactobacillus = 70: 19: 10: 1

[0183] Combination H: Carnosine 0.0001 - 0.5 parts;

[0184] Solvent: Water is supplemented to 100 parts.

[0185] Example 2 - 2

[0186] The difference from Example 1 is that the preparation method of the soybean milk fermentation filtrate is as follows:

[0187] (7) After washing the soybeans, soak them in water at room temperature for 12 h, and then grind them according to the ratio of soybeans to distilled water of 1:2 to obtain the crude soybean milk.

[0188] (8) After mixing the crude soybean milk obtained in step (1) with Medium A, add Strain A and ferment aerobically at 35 °C for 1 d.

[0189] (9) Filter the product obtained in step (2) to obtain the fermentation filtrate, and then heat and evaporate until the mass is the same as the mass of the soybeans in step (1), and the soybean milk fermentation filtrate can be obtained.

[0190] Among them, the components of Medium A are 1000.0 mL of potato juice, 10.0 g of glucose, and 15.0 - 20.0 g of agar.

[0191] The strain A is Bacillus amyloliquefaciens, China Center for Industrial Culture Collection, 20164. The inoculation amount is 6 vol% of the medium.

[0192] The mass ratio of the crude soybean milk to Medium A is 1:5.

[0193] Example 2-3

[0194] The difference from Example 1 is that the preparation method of the fermented soybean milk filtrate is as follows:

[0195] (10) After washing the soybeans, soak them in water at room temperature for 12 h, and then grind them according to the ratio of soybeans to distilled water of 1:2 to obtain crude soybean milk;

[0196] (11) After mixing the crude soybean milk obtained in step (1) with Medium A, add Strain A, and perform aerobic fermentation at 35 °C for 1 d; then add 3 wt% (3 wt% of Medium A) of beef extract powder and Strain B, and then perform aerobic fermentation at 30 °C for 3 d;

[0197] (12) Filter the product in step (2) to obtain a fermented filtrate, and then heat and evaporate until the mass is the same as the mass of the soybeans in step (1), thus obtaining the fermented soybean milk filtrate.

[0198] Among them, the components of Medium A are 1000.0 mL of potato juice, 10.0 g of glucose, and 15.0 - 20.0 g of agar.

[0199] Strain A is Bacillus amyloliquefaciens, China Center for Industrial Culture Collection, 20164. The inoculation amount is 1 vol% of the medium.

[0200] Strain B is Bacillus subtilis, China Center for Industrial Culture Collection, 24782. The inoculation amount is 5 vol% of the medium.

[0201] The mass ratio of the crude soybean milk to Medium A is 1:5.

[0202] Example 2-4

[0203] The difference from Example 1 is that the preparation method of the fermented soybean milk filtrate is as follows:

[0204] (13) After washing the soybeans, soak them in water at room temperature for 12 h, and then grind them according to the ratio of soybeans to distilled water of 1:2 to obtain crude soybean milk;

[0205] (14) After mixing the crude soybean milk obtained in step (1) with Medium A', add Strain A, Strain B, and Strain C, and perform aerobic fermentation at 35 °C for 4 d;

[0206] (15) Filter the product of step (2) to obtain the fermentation filtrate, and then heat and evaporate it until its mass is the same as that of the soybeans in step (1), thereby obtaining the fermented filtrate of soybean milk.

[0207] Among them, the components of the culture medium A' are 1000.0 mL of potato juice, 10.0 g of glucose, 15.0 - 20.0 g of agar, and 3 wt% (3 wt% of the culture medium A') of beef extract powder.

[0208] The strain A is Bacillus amyloliquefaciens, China Center for Industrial Culture Collection, 20164. The inoculation amount is 1 vol% of the culture medium.

[0209] The strain B is Bacillus subtilis, China Center for Industrial Culture Collection, 24782. The inoculation amount is 3 vol% of the culture medium.

[0210] The strain C is Bacillus subtilis, China Center for Industrial Culture Collection, 22129. The inoculation amount is 2 vol% of the culture medium.

[0211] The mass ratio of the crude soybean milk to the culture medium A is 1:5.

[0212] Example 3 - 1

[0213] The difference from Example 1 is that it does not contain component G.

[0214] Example 3 - 2

[0215] The difference from Example 1 is that it does not contain component E.

[0216] Example 3 - 3

[0217] The difference from Example 1 is that it does not contain component F.

[0218] Example 4 - 1

[0219] The difference from Example 1 is that the molecular weight of the sodium hyaluronate is 1,000,000 - 1,500,000, and it is purchased from Dongying Forest Biotechnology Co., Ltd.

[0220] Example 4 - 2

[0221] The difference from Example 1 is that the polydimethylsiloxane is purchased from Sigma - Aldrich (Shanghai) Trading Co., Ltd., and its viscosity is 100 cP (25 °C) (lit.)

[0222] Example 4-3

[0223] The difference from Example 1 is that the preparation raw materials do not include Capparis spinosa fruit extract.

[0224] Performance test

[0225] Test 1: 55 subjects were provided with the emulsions prepared in the above examples respectively (Subjects: A total of 55 valid subjects completed the test, including 15 males and 40 females, aged 19 to 58 years old, with an average age of 40.27 ± 12.88 years old, meeting the volunteer inclusion and exclusion criteria for subjects). The application location was on the facial skin of the subjects, and the water separation situation was observed. The test results are shown in Table 1.

[0226] Test 2: Heat resistance experiment, which means that the emulsions prepared in the examples were left standing in an incubator at 40 degrees for 24 hours, and after returning to room temperature, there were no phenomena such as separation, stratification, precipitation, etc. in the products; the test results are shown in Table 1. For the products with no change in shape, the method of Test 1 was adopted for testing, and the water separation situation was observed. The test results are shown in Table 1.

[0227] Test 3: Skin feel experiment. For the example products that passed Test 1 and Test 2, the subjects felt the skin from the start of absorption of the emulsion on the face until complete absorption, to see if there were feelings such as tightness, false dryness, greasiness, etc.

[0228]

[0229]

[0230] Test 4: Human safety and efficacy evaluation test items

[0231] Materials and methods

[0232] 1. Test substances: Example 1, Example 2-3, Example 3-1.

[0233] 2. Negative control: Blank control.

[0234] 3. Subjects: A total of 30 people, including 3 males and 27 females, aged 22 to 57 years old, with an average age of 43.87 ± 10.79 years old, meeting the volunteer inclusion criteria for subjects.

[0235] 4. Patch test method: Select qualified patch test equipment, and use the closed patch test method. Place about 0.020 g - 0.025 g of the test substance in the patch tester, and apply it to the back of the subject with a low-sensitization tape. After 24 hours, remove the test substance, and observe the skin reaction at 0.5, 24, and 48 hours after removal respectively. Record the results and test results according to the skin reaction grading standard in the "Cosmetics Safety and Technical Specifications" (2015 Edition).

[0236] Summary of the results of human skin patch tests

[0237]

[0238] Test 5: Test method for the freckle-removing and whitening efficacy of cosmetics - The first method: Test method for the freckle-removing and whitening efficacy of the ultraviolet-induced human skin melanization model

[0239] Materials and methods

[0240] 1. Test products: Example 1, Example 2-3, Example 3-1

[0241] 2. Negative control: Blank control in the melanized area

[0242] 3. Positive control: 7% ascorbic acid (vitamin C) product, prepared according to the formula in Appendix I of the Announcement No. 17 of 2021 of the National Medical Products Administration in the Cosmetics Safety and Technical Specifications (2015 Edition)

[0243] 4. Subjects: A total of 30 effective subjects completed the test, including 7 males and 23 females, aged 19 to 58 years, with an average age of 40.27 ± 12.88 years, meeting the volunteer inclusion and exclusion criteria for subjects

[0244] 5. Instruments and equipment

[0245] 5.1 Solar simulator: All performance indicators meet the requirements of the determination specification

[0246] 5.2 Skin colorimeter: An instrument that can measure the data of the CIE L*a*b color space. 5.3 Skin melanin detector: An instrument that detects the MI value of the skin based on the principle of spectral absorption

[0247] 6. Test method: Conduct the test according to the specific requirements of the Cosmetics Safety and Technical Specifications (2015 Edition). Select the non-exposed area of the subject's thigh as the test site, and the area of each melanization test area should be not less than 0.5 cm 2 and should be located within each sample application area. Determine the MED of the subject's test site. Use the solar simulator to irradiate once a day at the same irradiation point at a dose of 0.75 times the MED for 4 consecutive days. The 4 days after the irradiation end are the skin melanization period, without any treatment. On the 5th day after the irradiation end, visually evaluate and detect the skin color of each test area with a skin color instrument, and eliminate the test areas with poor consistency. Starting from the 5th day, apply the corresponding test substance to each melanization test area according to the random table, and continuously apply the test substance for at least 4 weeks. Visually evaluate and detect the skin color at 1 week, 2 weeks, 3 weeks, and 4 weeks after the application, and record

[0248] Table 3 Skin MI difference value before and after product use (mean ± standard deviation)

[0249]

[0250]

[0251] The presence of plant extracts will affect the effluent quality. The use of cyclic peptides can effectively alleviate the effluent quality problems caused by the addition of plant extract components; however, the addition of cyclic peptides cannot solve the effluent problems under temperature differences at the same time. The inventors found that adding soy milk fermentation broth and the above components simultaneously has better efficacy. The reason is that it can not only physically form a network but also promote the absorption of components to form a protective layer on the skin surface. Therefore, a formula with good moisturizing, whitening, and anti-wrinkle effects can be obtained.

[0252] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A one-touch water whitening and spot-lightening composition, characterized in that: In parts by mass, the composition comprises: pH adjuster: sodium hydroxide 0.01-0.15 parts; chelating agent: disodium EDTA 0.01-0.2 parts; Moisturizer: 0.1-10 parts of butylene glycol, 0.1-10 parts of propylene glycol, 0.01-0.1 parts of sodium hyaluronate; Fragrance: essence 0.01-0.1 parts; preservatives: methylparaben 0.1-0.3 parts, phenoxyethanol 0.1-0.5 parts; emulsifier: propylene glycol laurate 0.3 parts; emollients: caprylyl polymethicone 0.5-2 parts, caprylic / capric triglyceride 0.1-5 parts, polydimethylsiloxane 0.1-5 parts, damascena rose flower oil 0.001-0.1 parts; stabilizer: soy milk fermentation filtrate 3 parts, butanol polyether-3 6.25 parts, sodium benzotriazolyl butylphenol sulfonate 3.25 parts, tributyl citrate 0.5 parts; thickener: acetyl glucosamine 0.2 parts, ethyl cellulose 0.2 parts, propylene glycol isostearate 0.1 parts, carbomer 0.05-0.6 parts, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer 0.01-0.5 parts; plant extracts: gentian root extract 0.01 parts, yeast / acetobacter xylinum / black tea fermentation product 0.5 parts, caper fruit extract 0.02 parts, peony root extract 0.01 parts; Skin conditioning agent: Contains: niacinamide 0.1-3 parts; 1,2-hexanediol 0.2-1.5 parts; allantoin 0.05-0.3 parts; combination A: betaine, water 0.1-3 parts; combination B: xylitol glucoside, dehydrated xylitol, water, xylitol, glucose 0.05-1.0 parts; acetyl hexapeptide-8 0.001-0.1 parts; combination C: water, phenoxyethanol, palmitoyl pentapeptide-4, polysorbate-20, ethylhexylglycerin, polyacrylic acid, arginine 0.001-0.1 parts; combination D: water, polysorbate-20, carbomer, phenoxyethanol, ethylhexylglycerin, palmitoyl tripeptide-1 0.001-0.1 parts; combination E: water, 1,2-hexanediol, nonapeptide-1 0.001-0.1 parts; combination F: glycerin, water, palmitoyl tripeptide-5 0.001-0.1 parts; Combination G: α-glucan oligosaccharide, chrysanthemum root juice, maltodextrin, lactobacillus 0.001-0.1 parts; Combination H: carnosine 0.0001-0.5 parts; Solvent: water is added to 100 parts; Wherein, the viscosity of the polydimethylsiloxane is 5±0.5 mPa·S; the molecular weight of the sodium hyaluronate is 200,000 to 400,000; The preparation method of the soymilk fermentation filtrate is as follows: (1) Soybeans were washed and soaked in room temperature water for 12 h, and then ground in a ratio of 1:2 to obtain crude soy milk; (2) After mixing the crude soy milk obtained in step (1) with culture medium A, strain A was added, and aerobic fermentation was performed at 35° C. for 1 day; then 3 wt% of beef extract powder of culture medium A, strains B and strain C were added, and then aerobic fermentation was performed at 30° C. for 3 days; (3) filtering the product from step (2) to obtain a fermentation filtrate, and then heating and evaporating the product until its mass is the same as that of the soybeans from step (1), thereby obtaining the soymilk fermentation filtrate; The composition of the culture medium A is 1000.0 mL of potato juice, 10.0 g of glucose, and 15.0-20.0 g of agar; The strain A is Bacillus amyloliquefaciens, China Industrial Microbiological Culture Collection Center, CICC®20164; the inoculation amount is 1 vol% of the culture medium; The strain B is Bacillus subtilis, China Industrial Microbiological Culture Collection Management Center, CICC®24782; the inoculation amount is 3 vol% of the culture medium; The bacterial strain C is Bacillus subtilis, China Industrial Microbiological Culture Collection Management Center, CICC®22129; the inoculation amount is 2 vol% of the culture medium; The mass ratio of the crude soy milk to the culture medium A is 1:

5.

2. A one-touch whitening and spot-lightening lotion, characterized in that: The composition is prepared from the one-touch water whitening and spot-removing composition as claimed in claim 1.

3. The one-touch water-whitening and spot-lightening emulsion according to claim 2, characterized in that: The preparation method is as follows: S01. Clean and disinfect production equipment; Pretreatment 1: Pre-dissolve the raw materials of phase B, stir evenly and set aside; Pretreatment 2: Soak the phase C raw material one day in advance until it is uniform and transparent, and homogenize it with an external homogenizer; S02, add phase A water into the emulsifying pot, heat to 80-85°C, add the remaining raw materials of phase A and phase B in pretreatment 1, stir and keep warm to dissolve until clear and transparent, then add phase C in pretreatment 2, vacuum and homogenize for 5-8 minutes, and keep warm for 10-15 minutes; S03, add the raw materials of phase D into the oil pan, stir and heat to 80-85°C, fully dissolve, keep warm for 3-5 minutes, and then pump into the emulsification pot; after vacuuming and homogenizing for 5-8 minutes, add the raw materials of phase E, vacuumize and homogenize again for 5 minutes, and stir and keep warm for 15 minutes; S04. When the temperature drops to 45°C, add the raw materials of phase F and stir evenly; S05, cool down to 35-38℃, send for inspection, and after passing the inspection, filter out the material through 400 mesh; S06, filling and packaging; after passing the inspection, the finished products are put into storage; in: Phase A materials: some solvents, propylene glycol, butylene glycol, methylparaben, allantoin, disodium EDTA; Phase B raw materials: sodium hyaluronate; Phase C materials: Carbomer, remaining solvent Phase D ingredients: Caprylyl polymethicone, caprylic / capric triglyceride, dimethicone, propylene glycol laurate, ethylcellulose, propylene glycol isostearate, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer; Phase E raw materials: sodium hydroxide Ingredients for Phase F: phenoxyethanol, skin conditioning agent combination B, niacinamide, acetyl hexapeptide-8, soy milk fermentation filtrate, combination A, flavor, butanol polyether-3, sodium benzotriazolyl butylphenol sulfonate, tributyl citrate, 1,2-hexanediol, combination C, carnosine, combination D, combination E, combination F, combination G, damask rose flower oil, gentian root extract, yeast / acetobacter xylinum / black tea fermentation product, caper fruit extract, peony root extract.

4. The one-touch whitening and spot-lightening composition according to claim 1, characterized in that: Used in the field of whitening and skin care.

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