A pharmaceutical granule screening device for biopharmaceuticals

Abstract

The present invention discloses a pharmaceutical granule screening device for biopharmaceuticals, which relates to the technical field of pharmaceutical screening. Through the high-speed air flow in the air separation pipe, the present invention utilizes the differences in the gravity and windward area of pharmaceutical granules to achieve equilibrium at different heights, thereby realizing the precise stratification and screening of pharmaceutical granules of different sizes. Compared with traditional mechanical screening and electrostatic screening methods, the screening efficiency and accuracy are greatly improved; screening is carried out using the principle of aerodynamics, avoiding the impact and friction caused by mechanical vibration, significantly reducing the possible damage suffered by pharmaceutical granules during the screening process, and thus improving the quality and effectiveness of pharmaceuticals; through the combination of an electromagnet and a planetary gearbox, the automatic reciprocating motion of the stripping push plate is realized, and the pharmaceutical granules at different heights are pushed into the corresponding discharge channels. The entire process requires no manual intervention, greatly improving the automation degree and production efficiency of the screening process.

Description

Technical Field

[0001] The present invention relates to the technical field of drug screening, and specifically to a drug particle screening device for biopharmaceuticals. Background Art

[0002] In existing drug particle screening devices, mechanical screening or electrostatic screening methods are usually adopted. Although these methods can work effectively in some cases, there are also many deficiencies. The mechanical screening method relies on mechanical vibration, which is likely to cause damage to drug particles, reducing the quality and effectiveness of drugs. The electrostatic screening method is greatly affected by environmental humidity and the electrostatic properties of particles, with unstable screening effects, and the equipment is complex and difficult to maintain. In addition, when dealing with drug particles of different sizes, these traditional methods cannot distinguish quickly and accurately, resulting in low screening efficiency and production capacity unable to meet the needs of modern pharmaceutical industry. Summary of the Invention

[0003] To overcome the defects of the above-mentioned prior art, the present invention provides the following technical solution: A drug particle screening device for biopharmaceuticals, including layered support plates arranged in multiple layers in a stacked manner, with a distance provided between adjacent two layered support plates, and peeling push plates are slidably arranged between all adjacent two layered support plates; two discharge channels are symmetrically fixed on each layer of layered support plate, the bottom ends of all discharge channels are flush, the discharge channel corresponding to the top layer can penetrate through all the lower layered support plates, and at the position of each discharge channel on each layer of layered support plate, a limiting shielding plate is fixedly arranged, which is used to block the leakage of drug particles and can also guide the drug particles to slide from the layered support plate into the discharge channel; a gas separation pipe is fixed on the lower surface of one of the layered support plates at the bottom layer, a fan is rotatably installed at the bottom of the inner wall of the gas separation pipe, and a bottom shielding net is covered on the fan and fixed on the inner wall of the gas separation pipe.

[0004] Preferably, gas passing round holes with the same diameter as the inner wall of the gas separation pipe are provided at the positions of all layered support plates corresponding to the gas separation pipe.

[0005] Preferably, all layered support plates are fixed on the inner wall of the outer peripheral cylinder wall, a top support plate is fixedly installed at the topmost end of the outer peripheral cylinder wall, and a feeding rotating pipe is rotatably installed on the top support plate.

[0006] Preferably, all peeling push plates are fixedly sleeved and installed on the feeding rotating pipe, and a driving execution gear ring fixedly matched with the feeding rotating pipe is rotatably installed at the center of the upper surface of the top support plate.

[0007] Preferably, the rotation radius of the stripping push plate is the same as the radius of the layered support plate. A through hole with the same inner wall diameter as the air flow separation tube is provided at the position on the top support plate corresponding to the air flow separation tube. A top shielding net mounting ring is fixedly installed in the through hole, and a top shielding net is fixedly installed inside the top shielding net mounting ring. The lower surface of the top shielding net is flush with the lower surface of the top support plate. A stripping push plate is also slidably installed between the upper surface of the topmost layered support plate and the lower surface of the top support plate.

[0008] Preferably, an overhead base is fixedly installed at the bottom end of the outer peripheral cylinder wall for elevating the overhead outer peripheral cylinder wall. A frame is fixedly installed at the top end of the outer peripheral cylinder wall or on the top support plate, and an impeller is rotatably installed on the frame; a side plate extension pipe is fixedly connected and installed on the outer wall of the air flow separation tube. One end of the side plate extension pipe away from the air flow separation tube is fixedly installed with a feeding pipe orifice that is rotationally connected and matched with the bottom end of the feeding rotary pipe. A throwing wheel disc is coaxially rotatably installed in the feeding pipe orifice. A gap allowing all drug particles to pass through is left between the edge of the throwing wheel disc and the inner wall of the feeding pipe orifice. A rotating shaft is fixedly installed at the rotation axis of the throwing wheel disc, and the rotating shaft is connected by a transmission belt to the impeller.

[0009] Preferably, a gearbox support frame is also fixedly installed on the upper surface of the top support plate. The gearbox support frame is rotationally matched with the feeding rotary pipe. A planetary gearbox is fixedly installed on the gearbox support frame. A driving gear meshing and driving with the driving execution gear ring is fixedly installed on the output shaft of the planetary gearbox, and a driven gear is fixedly installed on the input shaft of the planetary gearbox.

[0010] Preferably, a sliding rod frame is also fixedly installed on the top support plate. A rack is slidably installed on the sliding rod frame. The rack meshes and drives with the driven gear. One end of the rack is fixed with an iron block. An electromagnet magnetically cooperating with the iron block is fixedly installed on the top support plate. A return spring is elastically installed between the rack and the electromagnet. The return spring is arranged around the sliding rod frame.

[0011] Compared with the prior art, the present invention has the following beneficial effects: (1) Through the high-speed air flow in the air flow separation tube, the present invention utilizes the different gravity and windward areas of drug particles to achieve balance at different heights, realizing the precise layered screening of drug particles of different sizes. Compared with traditional mechanical screening and electrostatic screening methods, the screening efficiency and accuracy are greatly improved; (2) The present invention uses the principle of aerodynamics for screening, avoiding the impact and friction caused by mechanical vibration, significantly reducing the possible damage suffered by drug particles during the screening process, thereby improving the quality and effectiveness of drugs; (3) Through the combination of the electromagnet and the planetary gearbox, the present invention realizes the automatic reciprocating movement of the stripping push plate, pushing the drug particles at different heights into the corresponding discharge channels. The whole process does not require manual intervention, greatly improving the automation degree and production efficiency of the screening process. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 This is a schematic diagram of the overall structure of the present invention.

[0013] Figure 2 This is the present invention Figure 1 Schematic diagram of the structure at position A in the present invention.

[0014] Figure 3 This is a schematic diagram of the structure at the layered support plate of the present invention.

[0015] Figure 4 This is the present invention Figure 3 Schematic diagram of the structure at position B in the present invention.

[0016] Figure 5 This is a schematic diagram of the structure at the peeling push plate of the present invention.

[0017] Figure 6 This is a schematic diagram of the discharge channel structure of the present invention.

[0018] Figure 7 This is a schematic diagram of the structure at the limiting shielding plate of the present invention.

[0019] Figure 8 This is a schematic diagram of the air flow separation pipe structure of the present invention.

[0020] Figure 9 This is a schematic diagram of the structure at the feeding pipe orifice of the present invention.

[0021] In the figure: 101 - air flow separation pipe; 102 - bottom shielding net; 103 - fan; 104 - side plate extension pipe; 105 - feeding pipe orifice; 106 - top shielding net; 107 - top shielding net mounting ring; 108 - feeding rotating pipe; 109 - rotating shaft; 110 - peeling push plate; 111 - material throwing wheel disc; 112 - driving execution gear ring; 113 - limiting shielding plate; 114 - discharge channel; 115 - layered support plate; 116 - gas passing round hole; 117 - frame; 118 - impeller; 119 - transmission belt; 120 - sliding rod frame; 121 - top support plate; 122 - rack; 123 - iron block; 124 - passive gear; 125 - planetary gearbox; 126 - driving gear; 127 - gearbox support frame; 128 - electromagnet; 129 - return spring; 130 - peripheral cylinder wall; 131 - overhead base. DETAILED DESCRIPTION OF THE INVENTION

[0022] The following will further illustrate the technical solution of the present invention in conjunction with the attached Figures 1-9 drawings and through specific embodiments.

[0023] The present invention provides a pharmaceutical granule screening device for biopharmaceuticals, including a layered support plate 115 arranged in multiple layers and stacked, with a distance between adjacent two layered support plates 115. A stripping push plate 110 is slidably arranged between all adjacent two layered support plates 115; Two discharge channels 114 are symmetrically fixed on each layer of the layered support plate 115. The bottoms of all the discharge channels 114 are arranged flush. The discharge channel 114 corresponding to the top layer can penetrate all the lower layered support plates 115, and a limiting shielding plate 113 is fixedly arranged at the position of each layered support plate 115 corresponding to the discharge channel 114, which is used to block the leakage of pharmaceutical granules and can also guide the pharmaceutical granules to slide from the layered support plate 115 into the discharge channel 114; A gas flow separation pipe 101 is fixed on the lower surface of the bottommost layered support plate 115. A fan 103 is rotatably installed at the bottom of the inner wall of the gas flow separation pipe 101. A bottom shielding net 102 is covered on the fan 103, and the bottom shielding net 102 is fixed on the inner wall of the gas flow separation pipe 101. Gas passing round holes 116 with the same diameter as the inner wall of the gas flow separation pipe 101 are opened at the positions of all the layered support plates 115 corresponding to the gas flow separation pipe 101. All the layered support plates 115 are fixed on the inner wall of the outer peripheral cylinder wall 130. A top support plate 121 is fixedly installed at the topmost end of the outer peripheral cylinder wall 130. A feed rotating pipe 108 is rotatably installed on the top support plate 121. All the stripping push plates 110 are fixedly sleeved and installed on the feed rotating pipe 108. A driving execution gear ring 112 fixedly matched with the feed rotating pipe 108 is rotatably installed at the center of the upper surface of the top support plate 121. The rotation radius of the stripping push plate 110 is the same as the radius of the layered support plate 115. A through hole with the same diameter as the inner wall of the gas flow separation pipe 101 is opened at the position of the top support plate 121 corresponding to the gas flow separation pipe 101. A top shielding net mounting ring 107 is fixedly installed in the through hole. A top shielding net 106 is fixedly installed in the top shielding net mounting ring 107. The lower surface of the top shielding net 106 is flush with the lower surface of the top support plate 121. A stripping push plate 110 is also slidably installed between the upper surface of the topmost layered support plate 115 and the lower surface of the top support plate 121.The bottom end of the outer cylindrical wall 130 is fixedly installed with an overhead base 131 for raising the overhead outer cylindrical wall 130. A frame 117 is fixedly installed on the top end or the top support plate 121 of the outer cylindrical wall 130. An impeller 118 is rotatably installed on the frame 117. A side plate extension pipe 104 is fixedly connected and installed on the outer wall of the air flow separation pipe 101. One end of the side plate extension pipe 104 away from the air flow separation pipe 101 is fixedly installed with a feeding pipe orifice 105 that is rotatably connected and matched with the bottom end of the feeding rotary pipe 108. A throwing wheel disc 111 is coaxially and rotatably installed in the feeding pipe orifice 105. A gap allowing all medicine particles to pass through is left between the edge of the throwing wheel disc 111 and the inner wall of the feeding pipe orifice 105. A rotary shaft 109 is fixedly installed at the rotation axis of the throwing wheel disc 111. The rotary shaft 109 is connected and driven with the impeller 118 through a transmission belt 119. A gearbox support frame 127 is also fixedly installed on the upper surface of the top support plate 121. The gearbox support frame 127 is rotatably matched with the feeding rotary pipe 108. A planetary gearbox 125 is fixedly installed on the gearbox support frame 127. A driving gear 126 that meshes and drives with the driving execution gear ring 112 is fixedly installed on the output shaft of the planetary gearbox 125. A driven gear 124 is fixedly installed on the input shaft of the planetary gearbox 125. A sliding rod frame 120 is also fixedly installed on the top support plate 121. A rack 122 is slidably installed on the sliding rod frame 120. The rack 122 meshes and drives with the driven gear 124. One end of the rack 122 is fixed with an iron block 123. An electromagnet 128 that magnetically cooperates with the iron block 123 is fixedly installed on the top support plate 121. A return spring 129 is elastically installed between the rack 122 and the electromagnet 128. The return spring 129 is arranged around the sliding rod frame 120.

[0024] The number of the sliding rod frames 120 is two. The return springs 129 are arranged around both of the two sliding rod frames 120, and the rack 122 is slidably installed on the two sliding rod frames 120.

[0025] First, let the fan 103 rotate at high speed (which can be driven by a motor). The fan 103 drives the air to flow at high speed inside the air flow separation tube 101. At this time, the drug particles to be screened are poured into the feeding rotary tube 108. Since the high-speed air will spray out through the top shielding net 106, it will drive the impeller 118 above the top shielding net 106 to rotate at this time. The impeller 118 drives the rotary shaft 109 to rotate through the transmission belt 119. The rotation of the rotary shaft 109 drives the throwing wheel disc 111 to rotate. The rotation of the throwing wheel disc 111 will throw the falling drug particles towards the inner wall of the feeding pipe orifice 105, and then fall into the side plate extension tube 104. The drug particles slide down to the upper side of the bottom shielding net 102 through the side plate extension tube 104. Under the action of the air flow, the drug particles move upward. Since all the drug particles belong to the same kind of drug, their density is the same. The diameters of the drug particles of different sizes are different, so their windward areas are also different. Larger drug particles have a larger volume and thus a greater gravity, but due to their larger windward area, the air resistance they receive is also greater. Therefore, for drug particles of different sizes, they will find a specific equilibrium height in the air flow separation tube 101. At this height, the air resistance of the air flow is equal to the gravity of the drug particles. Larger drug particles will reach equilibrium at a lower position because they require greater air resistance (i.e., higher air flow speed) to balance their gravity. Smaller drug particles will reach equilibrium at a higher position because they require smaller air resistance (i.e., lower air flow speed) to balance their gravity.

[0026] At the same time, quickly and intermittently start and stop the electromagnet 128. When the electromagnet 128 is energized, it will attract the iron block 123. After the electromagnet 128 is powered off, the iron block 123 will be pushed away under the action of the return spring 129. Therefore, the iron block 123 will do reciprocating linear motion, and the rack 122 fixed to the iron block 123 will also move synchronously. At this time, the rack 122 drives the driven gear 124 to swing reciprocally. The driven gear 124 drives the driving gear 126 to rotate reciprocally through the planetary gearbox 125. The driving gear 126 drives the driving execution gear ring 112 to rotate reciprocally. The rack 122 drives the feeding rotary tube 108 to rotate reciprocally. The feeding rotary tube 108 drives all the peeling push plates 110 to swing reciprocally between the layered support plates 115. During this process, the peeling push plates 110 will pass above the air flow separation tube 101, thereby pushing the drug particles staying at different heights onto the layered support plates 115, and then pushing them to the limit shielding plate 113. They will fall into the corresponding discharge channels 114 under the shielding of the limit shielding plate 113. Therefore, a receiving container can be set below the corresponding discharge channels 114 to distinguish drug particles of different sizes.

Claims

1. A pharmaceutical granule screening device for biopharmaceuticals, characterized in that: It includes a layered support plate (115) arranged in multiple layers in a stacked manner, with a distance provided between two adjacent layered support plates (115), and a peeling push plate (110) is slidably arranged between all adjacent two layered support plates (115); On each layer of the layered support plate (115), two discharge channels (114) are symmetrically fixed. The bottoms of all the discharge channels (114) are flush. The discharge channel (114) corresponding to the top layer can penetrate through all the lower layered support plates (115), and at the position corresponding to the discharge channel (114) on each layer of the layered support plate (115), a limiting shielding plate (113) is also fixedly arranged, which is used to block the leakage of medicine particles and can also guide the medicine particles to slide from the layered support plate (115) into the discharge channel (114); On the lower surface of the bottommost layered support plate (115), an air flow separation pipe (101) is fixed. A fan (103) is rotatably installed at the bottom of the inner wall of the air flow separation pipe (101), and a bottom shielding net (102) is covered on the fan (103), and the bottom shielding net (102) is fixed on the inner wall of the air flow separation pipe (101); At the positions of all the layered support plates (115) corresponding to the air flow separation pipe (101), gas passing round holes (116) with the same inner wall diameter as the air flow separation pipe (101) are opened; all the layered support plates (115) are fixed on the inner wall of the outer peripheral cylinder wall (130). At the topmost end of the outer peripheral cylinder wall (130), a top support plate (121) is fixedly installed, and a feeding rotating pipe (108) is rotatably installed on the top support plate (121); all the peeling push plates (110) are fixedly sleeved and installed on the feeding rotating pipe (108), and a driving execution gear ring (112) fixedly matched with the feeding rotating pipe (108) is rotatably installed at the center of the upper surface of the top support plate (121); The rotation radius of the stripping push plate (110) is the same as the radius of the layered support plate (115); a through hole with the same diameter as the inner wall of the airflow separation tube (101) is opened at a position corresponding to the airflow separation tube (101) on the top support plate (121); a top shielding net mounting ring (107) is fixedly installed in the through hole; a top shielding net (106) is fixedly installed in the top shielding net mounting ring (107); the lower surface of the top shielding net (106) is flush with the lower surface of the top support plate (121); a stripping push plate (110) is also slidably installed between the upper surface of a layered support plate (115) at the top layer and the lower surface of the top support plate (121); an overhead base (131) is fixedly installed at the bottom end of the outer tube wall (130) for raising the overhead outer tube wall (130); A frame (117) is fixedly mounted on the top or upper support plate (121), and an impeller (118) is rotatably mounted on the frame (117); a side plate extension tube (104) is fixedly mounted on the outer wall of the airflow separation tube (101) in communication therewith; a feeding pipe opening (105) is fixedly mounted on one end of the side plate extension tube (104) away from the airflow separation tube (101) and is rotatably connected to and matched with the bottom end of the feeding rotating pipe (108); a material throwing wheel (111) is coaxially rotatably mounted in the feeding pipe opening (105); a gap is left between the edge of the material throwing wheel (111) and the inner wall of the feeding pipe opening (105) so as to allow all drug particles to pass through; a rotating shaft (109) is fixedly mounted at the rotation axis of the material throwing wheel (111), and the rotating shaft (109) and the impeller (118) are connected to each other via a transmission belt (119).

2. The pharmaceutical granule screening device for biopharmaceuticals according to claim 1, characterized in that: A gearbox support frame (127) is also fixedly mounted on the upper surface of the top support plate (121). The gearbox support frame (127) is rotatably matched with the feed rotating tube (108). A planetary gearbox (125) is fixedly mounted on the gearbox support frame (127). A driving gear (126) meshing with a driving execution gear ring (112) is fixedly mounted on the output shaft of the planetary gearbox (125). A driven gear (124) is fixedly mounted on the input shaft of the planetary gearbox (125).

3. A pharmaceutical granule screening device for biopharmaceuticals according to claim 2, characterized in that: A sliding rod frame (120) is also fixedly mounted on the top support plate (121), a rack (122) is slidably mounted on the sliding rod frame (120), the rack (122) is meshed with a passive gear (124) for transmission, an iron block (123) is fixed to one end of the rack (122), an electromagnet (128) that cooperates magnetically with the iron block (123) is fixedly mounted on the top support plate (121), a return spring (129) is elastically mounted between the rack (122) and the electromagnet (128), and the return spring (129) is arranged around the sliding rod frame (120).

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