Degradable metal closure clip, hemostatic system, and method of making a closure clip

Abstract

This invention discloses a biodegradable metal closure clip, a hemostasis system, and a method for preparing the closure clip, belonging to the field of medical device technology. The biodegradable metal closure clip is made of biodegradable metal materials such as pure magnesium or magnesium alloy. The clip includes a first clamping arm, a first inclined arm, an arc-shaped transition section, a second inclined arm, and a second clamping arm connected in sequence. Both the first and second clamping arms extend along a first direction and are spaced apart along a second direction. The angle between the first and second inclined arms is α, which is 80°–140°. The diameter of the arc-shaped transition section is 0.4 mm–0.7 mm. The biodegradable metal closure clip provided by this invention not only degrades in vivo but can also be continuously fired within the clamping forceps.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a biodegradable metal closure clip, a hemostasis system, and a method for preparing the closure clip. Background Technology

[0002] Metal closure clips are a type of hemostatic clip, primarily used during surgery to close tubular tissues such as blood vessels and the cystic duct. After being clipped, these tissues will close naturally upon physiological healing. Compared to traditional manual suturing, surgical hemostatic clips offer advantages such as ease of use, speed, significantly reduced time spent ligating blood vessels and lumens, decreased intraoperative and postoperative bleeding, and a lower risk of complications.

[0003] However, existing metal closure clips are often made of titanium. Titanium clips are relatively hard, and excessive clamping can cause tissue cutting. Furthermore, titanium clips are non-biodegradable and will remain in the body for a long time, causing harmful irritation and adverse effects on surrounding tissues. Moreover, existing biodegradable metal closure clips are curved in shape, making it impossible to push them in a straight line and fire continuously within the clamping forceps.

[0004] Therefore, there is an urgent need to provide a biodegradable metal closure clip, a hemostasis system, and a method for preparing the closure clip to solve the above problems. Summary of the Invention

[0005] The purpose of this invention is to provide a biodegradable metal closure clip, a hemostasis system, and a method for preparing the closure clip, which can not only be degraded in vivo, but also be continuously fired within the clamp.

[0006] To achieve the above objectives, the following technical solution is provided:

[0007] The biodegradable metal closure clip is made of biodegradable metal material. The biodegradable metal closure clip includes a first clamping arm, a first inclined arm, an arc-shaped transition section, a second inclined arm, and a second clamping arm connected in sequence. The first clamping arm and the second clamping arm both extend along a first direction and are spaced apart along a second direction. The included angle between the first inclined arm and the second inclined arm is A, and the angle A is 80°-140°. The diameter of the arc-shaped transition section is 0.4mm-0.7mm.

[0008] As an alternative to the biodegradable metal closure clip, a first misaligned connection segment is provided at the transition between the first clamping arm and the first inclined arm, and a second misaligned connection segment is provided at the transition between the second clamping arm and the second inclined arm, wherein the projection of the first clamping arm in the second direction does not overlap with the second clamping arm.

[0009] As an alternative to the biodegradable metal closure clamp, the first misaligned surface of the first clamping arm is provided with a first anti-slip structure, and the second misaligned surface of the second clamping arm is provided with a second anti-slip structure.

[0010] As an alternative to the biodegradable metal closure clip, the first anti-slip structure includes a first anti-slip tooth, and a plurality of the first anti-slip teeth are spaced apart along a first direction on the first clamping arm, and / or the second anti-slip structure includes a second anti-slip tooth, and a plurality of the second anti-slip teeth are spaced apart along a first direction on the second clamping arm.

[0011] As an alternative to the biodegradable metal closure clip, the projected tooth shape of a plurality of the first anti-slip teeth in the second direction is misaligned with that of a plurality of the second anti-slip teeth.

[0012] As an alternative to the biodegradable metal closure clip, the first inner side of the first clamping arm is provided with a third anti-slip structure, and the second inner side of the second clamping arm is provided with a fourth anti-slip structure.

[0013] As an alternative to the biodegradable metal closure clip, the third anti-slip structure includes a third anti-slip tooth, and a plurality of the third anti-slip teeth are spaced apart along a first direction on the first clamping arm, and / or the fourth anti-slip structure includes a fourth anti-slip tooth, and a plurality of the fourth anti-slip teeth are spaced apart along a first direction on the second clamping arm.

[0014] As an alternative to the biodegradable metal closure clip, the projection tooth profiles of several third anti-slip teeth and several fourth anti-slip teeth in the third direction are misaligned with each other.

[0015] The hemostasis system includes a clamp and a biodegradable metal closure clip as described above, wherein a plurality of the biodegradable metal closure clips are sequentially installed in the firing chamber of the clamp.

[0016] A method for preparing a closure clip, used to manufacture a biodegradable metal closure clip as described above, includes the following steps:

[0017] Pretreatment: The magnesium plate is cleaned and degreased.

[0018] First heat treatment: The magnesium plate is heated to a first preset temperature and held at that temperature for a first set time, and then cooled to room temperature;

[0019] Mechanical processing: The magnesium sheet is rolled or stretched;

[0020] Secondary heat treatment: The magnesium plate is heated to a second preset temperature and held at that temperature for a second preset time, and then cooled to room temperature;

[0021] Post-processing: Polishing and coating the surface of the magnesium plate;

[0022] Finished product processing: The biodegradable metal closure clip is manufactured by laser cutting, electrical discharge machining or machining.

[0023] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0024] The biodegradable metal closure clip provided by this invention is made of biodegradable metal materials such as pure magnesium or magnesium alloy. After implantation, the magnesium biodegradable metal closure clip gradually degrades, reducing the risk of restenosis caused by foreign bodies. The biodegradable metal closure clip has a U-shaped structure, which can be composed of a first clamping arm, a second clamping arm, an arc-shaped transition section, a first oblique arm, and a second oblique arm. The outer surfaces of the first and second oblique arms are flat, with an included angle of 80° to 140°, and are connected by the arc-shaped transition section to form the U-shaped structure. When the first and second clamping arms are deformed to clamp the blood vessel tissue, the structural design increases the deformation of the first and second clamping arms, ensuring sufficient clamping force after ligation, preventing breakage and failure of the closure clip, and avoiding damage to the clamped blood vessel, thus achieving a safe and efficient ligation effect. This biodegradable metal closure clip can be assembled inside a clipping forceps, with each forceps holding 20 to 30 clips. During use, the biodegradable metal closure clips can be continuously fired by striking the handle of the clipping forceps.

[0025] The hemostasis system provided by the present invention allows for the continuous firing of several biodegradable metal closure clips located within the firing chamber of the clamp, facilitating hemostasis at multiple blood vessels.

[0026] The method for preparing biodegradable metal closure clips provided by this invention can improve the yield strength, tensile strength, and elongation of magnesium plates, while reducing their base surface texture strength, thereby meeting the requirements for biodegradable metal closure clip materials. Attached Figure Description

[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments of the present invention will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the content of the embodiments of the present invention and these drawings without creative effort.

[0028] Figure 1 This is a schematic diagram of the biodegradable metal closure clip from a first-view perspective in an embodiment of the present invention;

[0029] Figure 2 This is a schematic diagram of the biodegradable metal closure clip from a second perspective in an embodiment of the present invention;

[0030] Figure 3 This is a schematic diagram of the biodegradable metal closure clip from a third-view perspective in an embodiment of the present invention;

[0031] Figure 4 This is a schematic diagram of the biodegradable metal closure clip from a fourth perspective in an embodiment of the present invention;

[0032] Figure 5 This is a flowchart of the method for preparing a biodegradable metal closure clip in an embodiment of the present invention.

[0033] Figure label:

[0034] 1. First clamping arm; 2. Second clamping arm; 3. Arc-shaped transition section; 4. First inclined arm; 5. Second inclined arm; 6. First misaligned connecting section; 7. Second misaligned connecting section;

[0035] 11. First misaligned surface; 111. First anti-slip tooth; 12. First inner surface; 121. Third anti-slip tooth;

[0036] 21. Second misaligned surface; 211. Second anti-slip tooth; 22. Second inner surface; 221. Fourth anti-slip tooth. Detailed Implementation

[0037] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0038] In the description of this invention, it should be noted that the terms "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this invention is in use. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0039] In the description of this invention, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0040] Embodiments of the present invention are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0041] To enable the biodegradable metal closure clip not only to degrade within the body but also to be continuously fired within the clamping forceps, this embodiment provides a biodegradable metal closure clip, which is described below in conjunction with... Figures 1 to 5 The specific content of this embodiment will be described in detail.

[0042] like Figure 1 As shown, the biodegradable metal closure clip is made of magnesium alloy. The biodegradable metal closure clip includes a first clamping arm 1, a first inclined arm 4, an arc-shaped transition section 3, a second inclined arm 5, and a second clamping arm 2 connected in sequence. The first clamping arm 1 and the second clamping arm 2 both extend along a first direction and are spaced apart along a second direction. The included angle between the first inclined arm 4 and the second inclined arm 5 is A, and the angle of A is 80°-140°. The diameter D of the arc-shaped transition section 3 is 0.4mm-0.7mm. It should be noted that the diameter D is the arc diameter of the arc-shaped transition section 3 along the centerline of the wall thickness direction.

[0043] In summary, the biodegradable metal closure clip provided by this invention is made of magnesium alloy. After implantation, the magnesium metal biodegradable closure clip gradually degrades, reducing the risk of restenosis caused by foreign bodies. The biodegradable metal closure clip has a U-shaped structure, which can be composed of a first clamping arm 1, a second clamping arm 2, an arc-shaped transition section 3, a first oblique arm 4, and a second oblique arm 5. The outer surfaces of the first oblique arm 4 and the second oblique arm 5 are flat, with an included angle of 80° to 140°, and are connected by the arc-shaped transition section 3 to form the U-shaped structure. When the first clamping arm 1 and the second clamping arm 2 are deformed to clamp the vascular tissue, the structural design increases the deformation of the first clamping arm 1 and the second clamping arm 2, ensuring sufficient clamping force after ligation, preventing breakage and failure of the closure clip, and avoiding damage to the clamped blood vessel, thus achieving a safe and efficient ligation effect. This biodegradable metal closure clip can be assembled inside a clipping forceps, with each forceps holding 20 to 30 clips. During use, the biodegradable metal closure clips can be continuously fired by striking the forceps handle.

[0044] For example, the angle between the outer surfaces of the first inclined arm 4 and the second inclined arm 5 is defined as A; different implementation groups are set up, and the diameter of the arc-shaped transition section 3 at the bottom of the closure clip is defined as D. The closure clip is used to completely clamp the silicone tube, and a tension gauge is used to test until the silicone tube detaches from the closure clip. The maximum force during this process is defined as the clamping force F. The clamping process of the closure clip is simulated by the finite element method, and the stress and strain distribution after the closure clip is closed is calculated. The most reasonable closure clip structure is optimized based on the maximum von Mises stress Mises_max (MPa) and the maximum plastic strain PE_max, thereby controlling the mechanical performance maintenance time and avoiding stress concentration that could lead to premature breakage of the ligation clip. Mechanical performance maintenance time test method: The closure clip clamps a silicone tube of a certain size and places it in a physiological saline solution at a temperature controlled at 37℃. The closure clip is observed to see if it breaks, and the corresponding mechanical performance maintenance time T is obtained. The finite element analysis and mechanical test results for each implementation group are shown in Table 1.

[0045] Table 1

[0046]

[0047] The plastic deformation of the closure clip affects its mechanical properties. Table 1 shows that the included angle and the diameter of the arc-shaped transition section 3 in the structure have a significant impact on the stress-strain distribution and mechanical property retention time of the biodegradable metal closure clip. When A and D are larger, the maximum plastic strain PE_max is higher, making the closure clip more prone to fracture and resulting in a shorter mechanical property retention time. Conversely, when A, D, and F are larger, the clamping performance of the closure clip is better, and it is less likely to detach.

[0048] Optionally, when PE_max is higher than 0.35, the mechanical properties of the biodegradable metal material are limited, and it is prone to breakage when the clamp is closed. When the clamping force F is less than 25N, the clamping performance of the clamp is unstable and it is prone to slippage and displacement.

[0049] According to the results in Table 1, when the included angle A is 100°-120° and the diameter D of the arc transition section 3 is 0.4mm-0.6mm, the clamping performance of the closed clamp is stable and the mechanical properties are maintained for a longer period of time. The most suitable structural parameters can be selected according to the material properties and actual needs.

[0050] like Figures 2 to 4As shown, further, a first misaligned connecting segment 6 is provided at the transition between the first clamping arm 1 and the first oblique arm 4, and a second misaligned connecting segment 7 is provided at the transition between the second clamping arm 2 and the second oblique arm 5. The projection of the first clamping arm 1 in the second direction does not overlap with the second clamping arm 2. By adding the first misaligned connecting segment 6 and the second misaligned connecting segment 7, the first clamping arm 1 and the second clamping arm 2 can be misaligned with each other. By clamping the biodegradable metal closure clip with clamping forceps, the first clamping arm 1 and the second clamping arm 2 of the biodegradable metal closure clip will converge inward until the first misaligned surface 11 of the first clamping arm 1 and the second misaligned surface 21 of the second clamping arm 2 interlock and close, so that the blood vessel is completely squeezed and closed, achieving the effect of rapid hemostasis.

[0051] Furthermore, the first misaligned surface 11 of the first clamping arm 1 is provided with a first anti-slip structure, and the second misaligned surface 21 of the second clamping arm 2 is provided with a second anti-slip structure. By adding the first and second anti-slip structures, the frictional resistance of the first misaligned surface 11 and the second misaligned surface 21 to the blood vessel can be increased, which can effectively prevent the blood vessel from slipping.

[0052] Optionally, such as Figure 3 Combination Figure 4 As shown, the first anti-slip structure includes first anti-slip teeth 111, with a plurality of first anti-slip teeth 111 spaced apart along a first direction on the first clamping arm 1, and / or the second anti-slip structure includes second anti-slip teeth 211, with a plurality of second anti-slip teeth 211 spaced apart along the first direction on the second clamping arm 2. By adding first anti-slip teeth 111 and second anti-slip teeth 211 spaced apart along the first direction, the clamping force on the blood vessel can be further guaranteed. The number of first anti-slip teeth 111 and second anti-slip teeth 211 can be designed according to actual conditions, and no further restrictions are imposed here.

[0053] Optionally, the projected tooth shape of several first anti-slip teeth 111 in the second direction is staggered with that of several second anti-slip teeth 211. This staggered fit can further compress and close the blood vessel, preventing incomplete closure.

[0054] Furthermore, the first inner surface 12 of the first clamping arm 1 is provided with a third anti-slip structure, and the second inner surface 22 of the second clamping arm 2 is provided with a fourth anti-slip structure. The first clamping arm 1 and the second clamping arm 2 undergo plastic deformation under the action of the clamping force. By adding the third and fourth anti-slip structures to their inner surfaces, the contact friction between the inner surface of the biodegradable metal closure clamp and the vascular tissue can be increased, effectively preventing the vascular tissue from slipping out.

[0055] Optionally, the third anti-slip structure includes third anti-slip teeth 121, with a plurality of third anti-slip teeth 121 spaced apart along the first direction on the first clamping arm 1, and / or the fourth anti-slip structure includes fourth anti-slip teeth 221, with a plurality of fourth anti-slip teeth 221 spaced apart along the first direction on the second clamping arm 2. By adding third anti-slip teeth 121 and fourth anti-slip teeth 221 spaced apart along the first direction, the clamping force on the blood vessel can be further guaranteed. The number of third anti-slip teeth 121 and fourth anti-slip teeth 221 can be designed according to actual conditions, and no further restrictions are imposed here.

[0056] Optionally, the projections of several third anti-slip teeth 121 and several fourth anti-slip teeth 221 in the third direction are staggered. The staggered arrangement of the anti-slip teeth increases the contact area between the anti-slip structure and the blood vessel, increases the friction, and helps to better close the blood vessel.

[0057] This embodiment also provides a hemostasis system, which includes a clamp and the aforementioned biodegradable metal closure clip. Several biodegradable metal closure clips are sequentially installed in the firing chamber of the clamp to facilitate rapid hemostasis of multiple blood vessels.

[0058] This embodiment also provides a method for preparing a closure clip, used to fabricate the biodegradable metal closure clip of this embodiment. This method, through specific heat treatment and mechanical processing steps, aims to improve the yield strength, tensile strength, and elongation of the magnesium sheet, while reducing its base surface texture strength, thereby meeting the requirements for biodegradable metal closure clip materials. Figure 5 As shown, the method for preparing the closure clip includes the following steps:

[0059] Pretreatment: Select high-quality magnesium sheets and perform surface cleaning and degreasing treatment to remove impurities and oil stains from the surface of the sheets, preparing them for subsequent processing.

[0060] First heat treatment: The pretreated magnesium sheet is heated to a first preset temperature and held at that temperature for a first set time, then cooled to room temperature. For example, the first preset temperature is 200℃-250℃, and the first set time is 1 hour-2 hours, allowing sufficient heat diffusion and homogenization to occur within the sheet. The sheet is then rapidly cooled to room temperature to form a fine crystalline structure, improving the sheet's strength and plasticity.

[0061] Mechanical processing: Specific mechanical deformation is applied to the heat-treated magnesium sheet, such as rolling or stretching. The deformation amount is controlled within a certain range (e.g., 10%-30%), and the deformation speed is moderate (e.g., 1mm / s-10mm / s). Mechanical processing can induce strains of different gradients within the sheet, further refining the grain structure and simultaneously controlling the preferred orientation of the grains, reducing the basal texture intensity. Note: The deformation amount mentioned in this embodiment refers to the change in thickness; if the thickness decreases by 10% after rolling, the deformation amount is 10%. The deformation speed refers to the mechanical rolling speed.

[0062] Secondary heat treatment: The mechanically treated magnesium sheet is reheated to a higher temperature, for example, heated to a second preset temperature and held at that temperature for a second preset time, and then cooled to room temperature. For example, the second preset temperature is 300℃-450℃, and the second preset time is 0.5 hours-1 hour, followed by water cooling treatment to promote the dynamic recrystallization process inside the sheet, further improving the microstructure and properties of the sheet.

[0063] Post-treatment: Polishing and coating the surface of the magnesium sheet. The coating may include plasma electrolytic oxidation coating, HA coating, superhydrophobic coating, and micro-arc oxidation coating, etc., without too many restrictions, to improve the corrosion resistance and service life of the magnesium sheet.

[0064] Finished Product Processing: The biodegradable metal closure clip is manufactured using laser cutting, electrical discharge machining, or other machining methods. The main raw materials for the biodegradable metal closure clip include pure magnesium, magnesium alloys, and other biodegradable metal materials. After implantation in the human body, it gradually degrades and is absorbed over time. This characteristic allows the magnesium metal implant to disappear naturally when no longer needed, avoiding the need for a second surgery for removal and reducing patient suffering and medical costs.

[0065] The above-described method for optimizing the performance of magnesium sheets can significantly improve their yield strength, tensile strength, and elongation. Yield strength can be increased by 30-60 MPa, tensile strength by 40-80 MPa, and elongation by 5%-15%. The optimized magnesium sheets exhibit better overall performance, meeting the requirements of the biodegradable metal closure clip material of this invention.

[0066] Specifically, an AZ31B magnesium sheet with dimensions of 200mm × 150mm × 1mm was selected as raw material and subjected to surface cleaning and degreasing treatment. The treated magnesium sheet was heated to 220℃, held at that temperature for 1.5 hours, and then rapidly cooled to room temperature. The sheet was then rolled at 220℃ with a deformation amount of 20% and a deformation speed of 5mm / s. The rolled sheet was then heated to 380℃, held at that temperature for 0.75 hours, and then water-cooled. The optimized magnesium sheet underwent surface polishing to improve its corrosion resistance and service life. After the above steps, the yield strength of the obtained magnesium sheet increased by 40MPa, the tensile strength increased by 60MPa, and the elongation increased by 8%.

[0067] Note that the above description is merely a preferred embodiment of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and various obvious changes, readjustments, and substitutions can be made without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments, and may include many other equivalent embodiments without departing from the concept of the present invention, the scope of which is determined by the scope of the appended claims.

Claims

1. A degradable metal closure clip characterised in that, Made of pure magnesium or magnesium alloy, the biodegradable metal closure clamp includes a first clamping arm (1), a first inclined arm (4), an arc-shaped transition section (3), a second inclined arm (5), and a second clamping arm (2) connected in sequence. The first clamping arm (1) and the second clamping arm (2) both extend along a first direction and are spaced apart along a second direction. The first direction and the second direction are perpendicular to each other. The angle between the first inclined arm (4) and the second inclined arm (5) is A, and the angle A is 100°-120°. The diameter of the arc-shaped transition section (3) is 0.4mm-0.6mm, and the diameter of the arc-shaped transition section (3) is the arc diameter of the arc-shaped transition section (3) along the centerline of the wall thickness direction. A first misaligned connecting segment (6) is provided at the transition point between the first clamping arm (1) and the first inclined arm (4), and a second misaligned connecting segment (7) is provided at the transition point between the second clamping arm (2) and the second inclined arm (5). The projection of the first clamping arm (1) in the second direction does not overlap with the second clamping arm (2).

2. The degradable metal closure clip of claim 1, wherein, The first misaligned surface (11) of the first clamping arm (1) is provided with a first anti-slip structure, and the second misaligned surface (21) of the second clamping arm (2) is provided with a second anti-slip structure.

3. The biodegradable metal closure clip according to claim 2, characterized in that, The first anti-slip structure includes a first anti-slip tooth (111), and a plurality of the first anti-slip teeth (111) are spaced apart along a first direction on the first clamping arm (1), and / or the second anti-slip structure includes a second anti-slip tooth (211), and a plurality of the second anti-slip teeth (211) are spaced apart along a first direction on the second clamping arm (2).

4. The biodegradable metal closure clip according to claim 3, characterized in that, The projected tooth shape of several first anti-slip teeth (111) in the second direction is misaligned with several second anti-slip teeth (211).

5. The biodegradable metal closure clip according to claim 1, characterized in that, The first inner side (12) of the first clamping arm (1) is provided with a third anti-slip structure, and the second inner side (22) of the second clamping arm (2) is provided with a fourth anti-slip structure.

6. The biodegradable metal closure clip according to claim 5, characterized in that, The third anti-slip structure includes a third anti-slip tooth (121), and a plurality of the third anti-slip teeth (121) are spaced apart along a first direction on the first clamping arm (1), and / or the fourth anti-slip structure includes a fourth anti-slip tooth (221), and a plurality of the fourth anti-slip teeth (221) are spaced apart along a first direction on the second clamping arm (2).

7. The biodegradable metal closure clip according to claim 6, characterized in that, The projection tooth shapes of a plurality of the third anti-slip teeth (121) and a plurality of the fourth anti-slip teeth (221) in the third direction are misaligned with each other, and the third direction is perpendicular to both the first direction and the second direction.

8. A hemostatic system, characterized in that, The device includes a clamping pliers and a biodegradable metal closure clip as described in any one of claims 1-7, wherein a plurality of the biodegradable metal closure clips are sequentially installed in the firing chamber of the clamping pliers.

9. A method for preparing a closure clip, characterized in that, Used to manufacture the biodegradable metal closure clip as described in any one of claims 1-7. Includes the following steps: Pretreatment: The magnesium plate is cleaned and degreased. First heat treatment: The magnesium plate is heated to a first preset temperature and held at that temperature for a first set time, and then cooled to room temperature; Mechanical processing: The magnesium sheet is rolled or stretched; Secondary heat treatment: The magnesium plate is heated to a second preset temperature and held at that temperature for a second preset time, and then cooled to room temperature; Post-processing: Polishing and coating the surface of the magnesium plate; Finished product processing: The biodegradable metal closure clip is manufactured by laser cutting, electrical discharge machining or machining.

Images