A method and device for automatic labeling of technetium-labeled drugs based on lead shielding

Abstract

The present invention relates to the field of marking test technology, and in particular to a method and device for automatic marking of technetium-labeled drugs based on lead shielding. The method comprises the following steps: performing auxiliary positioning processing on a rinsing tank containing component and a marking tank containing component by a technetium-labeled drug automatic marking device, obtaining a rinsing liquid extraction positioning position and a to-be-marked liquid injection reaction positioning position; performing shielded quantitative extraction processing on the rinsing tank containing component by a technetium-labeled drug automatic marking device, obtaining a quantitative sodium pertechnetate-containing rinsing liquid; performing reaction marking processing and recording on the quantitative sodium pertechnetate-containing rinsing liquid and the to-be-marked drug solution on the marking tank containing component by a technetium-labeled drug automatic marking device, generating a technetium-labeled drug reaction preparation marking process; performing radiation level statistical calculation and radiation shielding reaction intelligent control on the technetium-labeled drug reaction preparation marking process, obtaining a technetium-labeled drug reaction result finished product. The present invention can realize the automatic marking of technetium-labeled drugs.

Description

Technical Field

[0001] The invention relates to the field of labeling testing technology, and in particular to a method and device for automatically labeling technetium-labeled drugs based on lead shielding. Background Art

[0002] At present, the process of technetium-labeled drugs is manual drug labeling, and this traditional process usually causes a large radiation dose to the hands of operators. In order to improve this problem, automatic labeling is improved. By searching patent documents, the utility model patent with announcement number CN21931951U discloses "A sampling device for drugs labeled with technetium". The device includes a base, a rotating device, a hydraulic cylinder, gears, etc. When working, the piston rod is driven by a motor to draw liquid from a needle tube for sampling. The device realizes automatic sampling, but fails to solve the problem of quantitative activity, and still causes radiation to the operator. Summary of the invention

[0003] Based on this, it is necessary for the present invention to provide a method and device for automatic labeling of technetium-labeled drugs based on lead shielding to solve at least one of the above-mentioned technical problems.

[0004] To achieve the above object, a method for automatic labeling of technetium-labeled drugs based on lead shielding comprises the following steps:

[0005] Step S1: A rinsing tank containing part and a marking tank containing part are assisted in positioning by a technetium-labeled drug automatic marking device to obtain a rinsing liquid extraction positioning position and a to-be-labeled liquid injection reaction positioning position; a sodium pertechnetate rinsing liquid containing technetium-99m radioactive isotope and a to-be-labeled drug solution are respectively stored in the rinsing tank containing part and the marking tank containing part in the technetium-labeled drug automatic marking device;

[0006] Step S2: Based on the extraction location of the eluent, the eluent is shielded and quantitatively extracted from the eluent containing part of the eluent tank by a technetium-labeled drug automatic labeling device to obtain a quantitative sodium pertechnetate-containing eluent;

[0007] Step S3: automatically positioning the retractable structure of the lead shielding material in the automatic marking device for technetium-labeled drugs on the labeling tank containing part based on the injection reaction positioning position of the liquid to be labeled, and injecting a quantitative sodium pertechnetate-containing eluent into the labeling tank containing part through the syringe barrel; performing reaction labeling treatment and recording on the quantitative sodium pertechnetate-containing eluent and the drug solution to be labeled by the automatic marking device for technetium-labeled drugs, so as to generate a technetium-labeled drug reaction preparation labeling process;

[0008] Step S4: Perform statistical calculation of the radiation level of the technetium-labeled drug reaction preparation and marking process to obtain the radiation level value of the technetium-labeled drug reaction process; based on the radiation level value of the technetium-labeled drug reaction process, perform intelligent control of the radiation shielding reaction of the technetium-labeled drug reaction preparation and marking process through a technetium-labeled drug automatic marking device to obtain the finished product of the technetium-labeled drug reaction result.

[0009] The present invention firstly uses the lifting plate and iron column fixing mechanism in the technetium-labeled drug automatic marking device to perform auxiliary positioning processing on the corresponding processing processes of the elution tank containing part and the marking tank containing part, and can determine the auxiliary movement positioning position of the equipment in the device during the elution liquid extraction process and the injection reaction process of the liquid to be marked. This positioning processing can help accurately control the operating position of the equipment, thereby ensuring the accuracy and stability of the elution liquid extraction in the elution tank containing part and the injection of the marking liquid in the marking tank containing part. At the same time, by storing the sodium pertechnetate elution liquid containing the technetium-99m radioactive isotope on the elution tank containing part in the technetium-labeled drug automatic marking device, this step can ensure that the marking process is ready by storing the elution liquid extracted from the technetium-99m generator in the designated storage position in the device, and the subsequent preparation of the marked drug can be carried out. Moreover, by storing the drug solution to be marked on the marking tank containing part in the technetium-marked drug automatic marking device, the preparation of the marked drug can be completed. This step is a key link in the entire marking process, which can ensure that the preparation of the marked drug is sufficient and correct, thereby laying the foundation for subsequent marking work. Secondly, by combining the eluent extraction positioning position obtained in advance, the lifting plate and the iron column fixing mechanism in the technetium-marked drug automatic marking device are used to automatically position the lead shielding material retractable structure in the technetium-marked drug automatic marking device to the eluent tank containing part for corresponding eluent extraction processing, and set the corresponding quantitative extraction control point according to the eluent activity in the barrel during the extraction process to achieve quantitative stop of the eluent extraction process, which can solve the problem of quantitative activity of the eluent. This step can ensure that the technetium content in the eluent reaches the expected target, and at the same time, the syringe barrel is driven to move to the original position through the turntable to end the entire eluent extraction process, which can achieve the integrity and accuracy of the extraction process, thereby providing a reliable basis and data support for subsequent experimental operations. Then, by combining the injection reaction positioning position of the marked liquid obtained by analysis, the lifting plate and iron column fixing mechanism in the technetium-labeled drug automatic marking device are used to automatically position the lead shielding material retractable structure in the technetium-labeled drug automatic marking device onto the marking tank containing part, thereby ensuring that the marking tank containing part is completely shielded in the lead shielding material retractable structure, and by using a syringe barrel to accurately inject a quantitative sodium pertechnetate-containing eluent into the marking tank containing part. The key to this step is that it can ensure the accurate injection of the sodium pertechnetate-containing eluent and the precise control of the liquid in the marking tank containing part, thereby providing a reliable liquid basis for the subsequent marking process.The technetium-labeled drug automatic marking device is used to perform reaction marking on the quantitative sodium pertechnetate eluent and the drug solution to be marked according to the preset automatic marking control program, and the entire marking process is recorded. The key to this step is that it can realize the automated marking process, ensure the accuracy and consistency of the marking, and record the entire reaction process, thereby providing important data support for subsequent quality control and result analysis. Finally, by performing statistical calculations on the radiation level of the technetium-labeled drug reaction preparation marking process, the key to this step is that through the statistical calculation of the radiation level, the radiation risk in the marking process can be comprehensively evaluated, providing a scientific basis for subsequent radiation safety management. Based on the radiation level value of the reaction process, the lead shielding material retractable structure in the technetium-labeled drug automatic marking device is used to intelligently control the radiation shielding reaction of the marking process. The key to this step is that the thickness level of the shielding structure can be dynamically adjusted according to the accurate evaluation of the radiation level in the shielding structure, thereby realizing targeted radiation shielding control to minimize the impact of the radiation level on the environment and operators, while ensuring the smooth progress of the marking process and the stable quality of the marking results.

[0010] Preferably, the present invention also provides an automatic marking device for technetium-labeled drugs based on lead shielding, comprising a processor, a memory, a control panel, a retractable structure of lead shielding material, a syringe barrel, a accommodating component, a accommodating connection structure, a rotating connection mechanism, a gear with a slot, a lifting plate, an iron column fixing mechanism, and a computer program stored in the memory and executable on the processor, for executing the automatic marking method for technetium-labeled drugs based on lead shielding as described above, the accommodating component is connected to the control panel through an accommodating connection structure, the accommodating component comprises a rinsing tank accommodating component and a marking tank accommodating component, the syringe barrel comprises a piston connecting rod, a Hall flowmeter, a turntable, and an automatic propeller, the retractable structure of lead shielding material and the syringe barrel inside it are connected to the right side of the gear with a slot through a rotating connection mechanism, the control panel and the accommodating component are connected through an iron column fixing mechanism, and are connected to the left side of the gear with a slot through a lifting plate, and the processor and memory are configured in the control panel. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] Other features, objects and advantages of the present invention will become more apparent from the detailed description of non-limiting embodiments thereof made with reference to the following drawings:

[0012] Figure 1 It is a schematic flow chart of the steps of the automatic labeling method of technetium-labeled drugs based on lead shielding of the present invention;

[0013] Figure 2 for Figure 1 Detailed step flow diagram of step S1;

[0014] Figure 3 for Figure 2 Detailed step flow diagram of step S12;

[0015] Figure 4 It is a schematic structural diagram of the automatic marking device for technetium-labeled drugs based on lead shielding of the present invention. DETAILED DESCRIPTION

[0016] The following is a clear and complete description of the technical method of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by technicians in this field without creative work are within the scope of protection of the present invention.

[0017] In addition, the accompanying drawings are only schematic illustrations of the present invention and are not necessarily drawn to scale. The same reference numerals in the figures represent the same or similar parts, and their repeated description will be omitted. Some of the block diagrams shown in the accompanying drawings are functional entities and do not necessarily correspond to physically or logically independent entities. The functional entities can be implemented in software form, or implemented in one or more hardware modules or integrated circuits, or implemented in different networks and / or processor methods and / or microcontroller methods.

[0018] It should be understood that, although the terms "first", "second", etc. may be used herein to describe various units, these units should not be limited by these terms. These terms are used only to distinguish one unit from another unit. For example, without departing from the scope of the exemplary embodiments, the first unit may be referred to as the second unit, and similarly the second unit may be referred to as the first unit. The term "and / or" used herein includes any and all combinations of one or more of the listed associated items.

[0019] To achieve this, please refer to Figures 1 to 3 The present invention provides a method for automatic labeling of technetium-labeled drugs based on lead shielding, the method comprising the following steps:

[0020] Step S1: A rinsing tank containing part and a marking tank containing part are assisted in positioning by a technetium-labeled drug automatic marking device to obtain a rinsing liquid extraction positioning position and a to-be-labeled liquid injection reaction positioning position; a sodium pertechnetate rinsing liquid containing technetium-99m radioactive isotope and a to-be-labeled drug solution are respectively stored in the rinsing tank containing part and the marking tank containing part in the technetium-labeled drug automatic marking device;

[0021] Step S2: Based on the extraction location of the eluent, the eluent is shielded and quantitatively extracted from the eluent containing part of the eluent tank by a technetium-labeled drug automatic labeling device to obtain a quantitative sodium pertechnetate-containing eluent;

[0022] Step S3: automatically positioning the retractable structure of the lead shielding material in the automatic marking device for technetium-labeled drugs on the labeling tank containing part based on the injection reaction positioning position of the liquid to be labeled, and injecting a quantitative sodium pertechnetate-containing eluent into the labeling tank containing part through the syringe barrel; performing reaction labeling treatment and recording on the quantitative sodium pertechnetate-containing eluent and the drug solution to be labeled by the automatic marking device for technetium-labeled drugs, so as to generate a technetium-labeled drug reaction preparation labeling process;

[0023] Step S4: Perform statistical calculation of the radiation level of the technetium-labeled drug reaction preparation and marking process to obtain the radiation level value of the technetium-labeled drug reaction process; based on the radiation level value of the technetium-labeled drug reaction process, perform intelligent control of the radiation shielding reaction of the technetium-labeled drug reaction preparation and marking process through a technetium-labeled drug automatic marking device to obtain the finished product of the technetium-labeled drug reaction result.

[0024] In the embodiment of the present invention, please refer to Figure 1 FIG. 1 is a schematic diagram of the automatic labeling method of technetium-labeled drugs based on lead shielding of the present invention. In this example, the automatic labeling method of technetium-labeled drugs based on lead shielding includes the following steps:

[0025] Step S1: A rinsing tank containing part and a marking tank containing part are assisted in positioning by a technetium-labeled drug automatic marking device to obtain a rinsing liquid extraction positioning position and a to-be-labeled liquid injection reaction positioning position; a sodium pertechnetate rinsing liquid containing technetium-99m radioactive isotope and a to-be-labeled drug solution are respectively stored in the rinsing tank containing part and the marking tank containing part in the technetium-labeled drug automatic marking device;

[0026] The embodiment of the present invention uses a processor in the technetium-labeled drug automatic marking device to use virtual simulation technology to simulate and analyze the device use process of the rinsing tank containing part and the marking tank containing part respectively, so as to set the corresponding device parameters and run the simulation program to simulate and analyze in detail and understand the specific movement and change position of the corresponding equipment during the use of the device and the rinsing tank containing part and the marking tank containing part, and accurately locate the corresponding equipment during the actual operation process, so as to obtain the rinsing liquid extraction positioning position and the injection reaction positioning position of the liquid to be marked. Then, by storing the sodium pertechnetate rinsing liquid containing technetium-99m radioactive isotope extracted from the technetium-99m generator on the rinsing tank containing part in the technetium-labeled drug automatic marking device, and by storing the specific solution of the drug to be marked in the marking tank containing part at the symmetrical position of the rinsing tank containing part in the technetium-labeled drug automatic marking device, it is ensured that the preparation of the marked drug is sufficient and correct.

[0027] Step S2: Based on the extraction location of the eluent, the eluent is shielded and quantitatively extracted from the eluent containing part of the eluent tank by a technetium-labeled drug automatic labeling device to obtain a quantitative sodium pertechnetate-containing eluent;

[0028] The embodiment of the present invention uses the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic marking device to accurately position and adjust the lead shielding material retractable structure in the technetium-labeled drug automatic marking device to the elution tank containing part according to the positioning position obtained by combining the analysis of the eluent extraction positioning position, and adjusts the lead shielding material retractable structure to completely wrap the elution tank containing part inside by adjusting the lead shielding material retractable structure to achieve shielding. Secondly, by using the syringe barrel in the lead shielding material retractable structure to quantitatively control the extraction of the corresponding sodium pertechnetate eluent in the elution tank containing part according to the corresponding activity control standard, it is ensured that the technetium content in the eluent in the Hall flowmeter of the syringe barrel reaches the expected target, and at the same time, the syringe barrel is driven to move to the original position by the turntable to end the entire eluent extraction process, and finally a quantitative sodium pertechnetate eluent is obtained.

[0029] Step S3: automatically positioning the retractable structure of the lead shielding material in the automatic marking device for technetium-labeled drugs on the labeling tank containing part based on the injection reaction positioning position of the liquid to be labeled, and injecting a quantitative sodium pertechnetate-containing eluent into the labeling tank containing part through the syringe barrel; performing reaction labeling treatment and recording on the quantitative sodium pertechnetate-containing eluent and the drug solution to be labeled by the automatic marking device for technetium-labeled drugs, so as to generate a technetium-labeled drug reaction preparation labeling process;

[0030] The embodiment of the present invention firstly uses the lifting plate and the iron column fixing mechanism in the automatic marking device for marking drugs to accurately position and adjust the retractable structure of the lead shielding material in the automatic marking device for marking drugs to the marking tank accommodating component according to the positioning position obtained by combining the analysis of the injection reaction positioning position of the liquid to be marked, and adjusts the retractable structure of the lead shielding material in the automatic marking device for marking drugs to the marking tank accommodating component completely inside by adjusting the retractable structure of the lead shielding material to achieve shielding thereof, and at the same time, drives the entire syringe barrel to move to the inside of the marking tank accommodating component by controlling the rotation speed and direction of the turntable in the syringe barrel, and injects the quantitative sodium pertechnetate-containing eluent in the Hall flowmeter into the marking tank accommodating component by using an automatic propeller. Then, the quantitative sodium pertechnetate-containing eluent in the marking tank accommodating component and the drug solution to be marked are reacted by using the automatic marking control program (including the setting of parameters such as the time, temperature, and pressure of the marking reaction) pre-set by the processor in the automatic marking device for marking drugs, and records the entire marking process, and finally records the generation of the marking process of the reaction preparation of the marking of the technetium-labeled drug.

[0031] Step S4: Perform statistical calculation of the radiation level of the technetium-labeled drug reaction preparation and marking process to obtain the radiation level value of the technetium-labeled drug reaction process; based on the radiation level value of the technetium-labeled drug reaction process, perform intelligent control of the radiation shielding reaction of the technetium-labeled drug reaction preparation and marking process through a technetium-labeled drug automatic marking device to obtain the finished product of the technetium-labeled drug reaction result.

[0032] The embodiment of the present invention firstly statistically analyzes the duration of the entire technetium-labeled drug reaction preparation and marking process and the state degree of the drug reaction in the reaction process, and quantitatively calculates the radiation level in the technetium-labeled drug reaction preparation and marking process by combining the duration and reaction state degree obtained by the analysis, thereby obtaining the radiation level value of the technetium-labeled drug reaction process. Secondly, by combining the technetium-labeled drug reaction process radiation level value obtained by the analysis, the thickness level parameter of the retractable structure of the lead shielding material in the technetium-labeled drug automatic marking device is mined and analyzed using an associated mining analysis algorithm to explore and analyze the linear correlation between the reaction radiation level and the thickness of the shielding structure, so as to set an adaptive radiation shielding control strategy for the retractable structure of the lead shielding material in the technetium-labeled drug automatic marking device, including dynamically adjusting the thickness level parameter of the lead shielding material according to the real-time radiation level value in the structure, so as to achieve effective shielding control of the radiation in the reaction process, and ensure that the radiation level in the technetium-labeled drug reaction preparation and marking process can be effectively shielded and controlled, until the technetium-labeled drug reaction preparation and marking process reaction is completed, and finally the technetium-labeled drug reaction result finished product is obtained.

[0033] The present invention firstly uses the lifting plate and iron column fixing mechanism in the technetium-labeled drug automatic marking device to perform auxiliary positioning processing on the corresponding processing processes of the elution tank containing part and the marking tank containing part, and can determine the auxiliary movement positioning position of the equipment in the device during the elution liquid extraction process and the injection reaction process of the liquid to be marked. This positioning processing can help accurately control the operating position of the equipment, thereby ensuring the accuracy and stability of the elution liquid extraction in the elution tank containing part and the injection of the marking liquid in the marking tank containing part. At the same time, by storing the sodium pertechnetate elution liquid containing the technetium-99m radioactive isotope on the elution tank containing part in the technetium-labeled drug automatic marking device, this step can ensure that the marking process is ready by storing the elution liquid extracted from the technetium-99m generator in the designated storage position in the device, and the subsequent preparation of the marked drug can be carried out. Moreover, by storing the drug solution to be marked on the marking tank containing part in the technetium-marked drug automatic marking device, the preparation of the marked drug can be completed. This step is a key link in the entire marking process, which can ensure that the preparation of the marked drug is sufficient and correct, thereby laying the foundation for subsequent marking work. Secondly, by combining the eluent extraction positioning position obtained in advance, the lifting plate and the iron column fixing mechanism in the technetium-marked drug automatic marking device are used to automatically position the lead shielding material retractable structure in the technetium-marked drug automatic marking device to the eluent tank containing part for corresponding eluent extraction processing, and set the corresponding quantitative extraction control point according to the eluent activity in the barrel during the extraction process to achieve quantitative stop of the eluent extraction process, which can solve the problem of quantitative activity of the eluent. This step can ensure that the technetium content in the eluent reaches the expected target, and at the same time, the syringe barrel is driven to move to the original position through the turntable to end the entire eluent extraction process, which can achieve the integrity and accuracy of the extraction process, thereby providing a reliable basis and data support for subsequent experimental operations. Then, by combining the injection reaction positioning position of the marked liquid obtained by analysis, the lifting plate and iron column fixing mechanism in the technetium-labeled drug automatic marking device are used to automatically position the lead shielding material retractable structure in the technetium-labeled drug automatic marking device onto the marking tank containing part, thereby ensuring that the marking tank containing part is completely shielded in the lead shielding material retractable structure, and by using a syringe barrel to accurately inject a quantitative sodium pertechnetate-containing eluent into the marking tank containing part. The key to this step is that it can ensure the accurate injection of the sodium pertechnetate-containing eluent and the precise control of the liquid in the marking tank containing part, thereby providing a reliable liquid basis for the subsequent marking process.The technetium-labeled drug automatic marking device is used to perform reaction marking on the quantitative sodium pertechnetate eluent and the drug solution to be marked according to the preset automatic marking control program, and the entire marking process is recorded. The key to this step is that it can realize the automated marking process, ensure the accuracy and consistency of the marking, and record the entire reaction process, thereby providing important data support for subsequent quality control and result analysis. Finally, by performing statistical calculations on the radiation level of the technetium-labeled drug reaction preparation marking process, the key to this step is that through the statistical calculation of the radiation level, the radiation risk in the marking process can be comprehensively evaluated, providing a scientific basis for subsequent radiation safety management. Based on the radiation level value of the reaction process, the lead shielding material retractable structure in the technetium-labeled drug automatic marking device is used to intelligently control the radiation shielding reaction of the marking process. The key to this step is that the thickness level of the shielding structure can be dynamically adjusted according to the accurate evaluation of the radiation level in the shielding structure, thereby realizing targeted radiation shielding control to minimize the impact of the radiation level on the environment and operators, while ensuring the smooth progress of the marking process and the stable quality of the marking results.

[0034] Preferably, step S1 comprises the following steps:

[0035] Step S11: using the technetium-labeled drug automatic labeling device to simulate and analyze the device use process of the elution tank containing component and the labeling tank containing component, and obtain the elution liquid extraction simulation process and the labeled liquid injection reaction simulation process;

[0036] Step S12: performing virtual positioning processing on the eluent extraction simulation process and the marked liquid injection reaction simulation process to obtain the initial positioning position of the eluent extraction process and the initial positioning position of the marked liquid injection reaction process;

[0037] Step S13: using the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic labeling device to respectively perform auxiliary positioning calibration analysis on the initial positioning position of the eluent extraction process and the initial positioning position of the injection reaction process of the liquid to be labeled, so as to obtain the eluent extraction positioning position and the injection reaction positioning position of the liquid to be labeled;

[0038] Step S14: storing the sodium pertechnetate eluent containing technetium-99m radioactive isotope in the eluent tank containing component in the technetium-labeled drug automatic labeling device;

[0039] Step S15: storing the drug solution to be labeled in a labeling tank containing component in the technetium-labeled drug automatic labeling device.

[0040] As an embodiment of the present invention, refer to Figure 2 As shown, Figure 1Detailed step flow diagram of step S1 in FIG. 1 , in this embodiment, step S1 includes the following steps:

[0041] Step S11: using the technetium-labeled drug automatic labeling device to simulate and analyze the device use process of the elution tank containing component and the labeling tank containing component, and obtain the elution liquid extraction simulation process and the labeled liquid injection reaction simulation process;

[0042] The embodiment of the present invention uses virtual simulation technology through the processor in the technetium-labeled drug automatic labeling device to simulate and analyze the device use process of the elution tank containing component and the marking tank containing component respectively, so as to set the corresponding device parameters and run the simulation program to simulate and analyze in detail and understand the specific movement and change position of the corresponding equipment between the device and the elution tank containing component and the marking tank containing component during use, and finally obtain the elution liquid extraction simulation process and the marked liquid injection reaction simulation process.

[0043] Step S12: performing virtual positioning processing on the eluent extraction simulation process and the marked liquid injection reaction simulation process to obtain the initial positioning position of the eluent extraction process and the initial positioning position of the marked liquid injection reaction process;

[0044] The embodiment of the present invention uses a corresponding motion tracking program to identify and analyze the motion trajectory of the device equipment in the simulated eluent extraction simulation process and the labeled liquid injection reaction simulation process, so as to accurately capture the simulated movement trajectory of the equipment in the technetium-labeled drug automatic marking device during operation, including the movement path and trajectory law of the equipment in the eluent extraction process and the labeled liquid injection reaction process, and uses a timing change analysis technology to perform a detailed change analysis on the motion trajectory of the eluent extraction process equipment and the motion trajectory of the labeled liquid reaction process equipment, so as to analyze and obtain the position change and angle or direction change of the corresponding equipment in the time series, and then, by combining the position change and movement direction change obtained by the analysis, the corresponding equipment motion trajectory is virtually positioned to help accurately determine the initial positioning position of the corresponding equipment in the eluent extraction process and the labeled liquid reaction process, and ensure the accuracy of the equipment position in the eluent extraction process and the labeled liquid reaction process, and finally obtain the initial positioning position of the eluent extraction process and the initial positioning position of the labeled liquid injection reaction process.

[0045] Step S13: using the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic labeling device to respectively perform auxiliary positioning calibration analysis on the initial positioning position of the eluent extraction process and the initial positioning position of the injection reaction process of the liquid to be labeled, so as to obtain the eluent extraction positioning position and the injection reaction positioning position of the liquid to be labeled;

[0046] The embodiment of the present invention uses the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic marking device to perform actual operation processing on the corresponding initial positioning position of the eluent extraction process and the initial positioning position of the injection reaction process of the marked liquid and analyze the corresponding inertia of the movement process, which involves observing and recording the behavior of the device in actual operation, including movement, stability and response speed, etc., and identifying and quantitatively analyzing the inertial offset in the specific operation process based on the inertial data obtained by analysis, that is, the difference between the positioning position in the actual operation process and the expected position in the simulation process, and performing calibration calculations to determine the calibration value of the device movement positioning position in the actual operation process, and then, by using the calibration value obtained by analysis, calibrating the device positioning position with inertial offset in the initial positioning position of the corresponding operation process, so as to adjust the control parameters or mechanical structure of the device to correct the inertial offset, and ensure that the device can be accurately positioned in the actual operation process, and finally obtain the eluent extraction positioning position and the marking liquid injection reaction positioning position.

[0047] Step S14: storing the sodium pertechnetate eluent containing technetium-99m radioactive isotope in the eluent tank containing component in the technetium-labeled drug automatic labeling device;

[0048] The embodiment of the present invention ensures that the labeling process is ready by storing the sodium pertechnetate eluent containing technetium-99m radioactive isotope extracted from the technetium-99m generator on the eluent tank containing component in the technetium-labeled drug automatic labeling device.

[0049] Step S15: storing the drug solution to be labeled in a labeling tank containing component in the technetium-labeled drug automatic labeling device.

[0050] The embodiment of the present invention also ensures that the preparation of the marked medicine is sufficient and correct by storing the specific solution of the medicine to be marked in the marking tank containing part symmetrically located with the rinsing tank containing part in the automatic marking device for marking medicine with technetium.

[0051] The present invention first uses virtual simulation technology through the processor in the technetium-labeled drug automatic marking device to simulate and analyze the use process of the device for the rinsing tank containing parts and the marking tank containing parts, respectively, so as to understand in detail the specific movement and change of the position of the equipment during the use between the device and the rinsing tank containing parts and the marking tank containing parts. This step can obtain key operation details and process information by simulating the process of rinsing liquid extraction and injection of the liquid to be marked. This simulation analysis can help to deeply understand the operating principle of the equipment, thereby providing basic data guarantee for subsequent virtual positioning and positioning calibration. Secondly, by performing position virtual positioning processing on the simulated process of rinsing liquid extraction and injection of the liquid to be marked, the initial movement and positioning position of the equipment in the device during the rinsing liquid extraction process and the injection reaction process of the liquid to be marked can be determined. This positioning processing can help accurately control the operating position of the equipment and ensure the correct extraction and injection of the liquid. Then, by using the lifting plate and iron column fixing mechanism in the technetium-labeled drug automatic marking device to perform auxiliary positioning calibration analysis on the initial positioning position of the eluent extraction process and the injection reaction process of the liquid to be marked, the positioning accuracy of the lifting plate and the iron column fixing mechanism can be further optimized, thereby ensuring the accuracy and stability of the eluent extraction and the injection of the marking liquid. Next, by storing the sodium pertechnetate eluent containing the technetium-99m radioactive isotope in the eluent tank containing part in the technetium-labeled drug automatic marking device, this step can ensure that the marking process is ready by storing the eluent extracted from the technetium-99m generator in the designated storage position in the device, and subsequent preparation of the marked drug can be carried out. Finally, by storing the drug solution to be marked in the marking tank containing part in the technetium-labeled drug automatic marking device, the preparation of the marked drug can be completed. This step is a key link in the entire marking process, which can ensure that the preparation of the marked drug is sufficient and correct, thereby laying the foundation for subsequent marking work.

[0052] Preferably, step S12 comprises the following steps:

[0053] Step S121: performing device motion trajectory recognition and analysis on the eluent extraction simulation process and the labeled liquid injection reaction simulation process to obtain the device motion trajectory of the eluent extraction process and the device motion trajectory of the labeled liquid reaction process;

[0054] Step S122: analyzing the position change of the movement trajectory of the equipment in the process of eluent extraction and the movement trajectory of the equipment in the process of reaction of the liquid to be marked, and obtaining the movement position change data of the equipment in the process of eluent extraction and the movement position change data of the equipment in the process of reaction of the liquid to be marked;

[0055] Step S123: Analyze the direction change of the movement trajectory of the equipment in the process of eluent extraction and the movement trajectory of the equipment in the process of reaction of the liquid to be marked, and obtain the movement direction change data of the equipment in the process of eluent extraction and the movement direction change data of the equipment in the process of reaction of the liquid to be marked;

[0056] Step S124: performing virtual positioning processing on the movement trajectory of the equipment during the eluent extraction process based on the movement position change data of the equipment during the eluent extraction process and the movement direction change data of the equipment during the eluent extraction process to obtain the initial positioning position of the eluent extraction process;

[0057] Step S125: Based on the movement position change data of the equipment in the reaction process of the liquid to be marked and the movement direction change data of the equipment in the reaction process of the liquid to be marked, a virtual positioning process is performed on the movement trajectory of the equipment in the reaction process of the liquid to be marked to obtain the initial positioning position of the reaction process of the injection of the liquid to be marked.

[0058] As an embodiment of the present invention, refer to Figure 3 As shown, Figure 2 Detailed step flow diagram of step S12 in the embodiment, step S12 includes the following steps:

[0059] Step S121: performing device motion trajectory recognition and analysis on the eluent extraction simulation process and the labeled liquid injection reaction simulation process to obtain the device motion trajectory of the eluent extraction process and the device motion trajectory of the labeled liquid reaction process;

[0060] The embodiment of the present invention uses a corresponding motion tracking program to identify and analyze the motion trajectory of the device equipment in the simulated eluent extraction simulation process and the labeled liquid injection reaction simulation process, so as to accurately capture the simulated movement trajectory of the equipment in the technetium-labeled drug automatic labeling device during operation, including the movement path and trajectory rules of the equipment in the eluent extraction process and the labeling liquid injection reaction process, and finally obtain the motion trajectory of the equipment in the eluent extraction process and the motion trajectory of the equipment in the labeled liquid reaction process.

[0061] Step S122: analyzing the position change of the movement trajectory of the equipment in the process of eluent extraction and the movement trajectory of the equipment in the process of reaction of the liquid to be marked, and obtaining the movement position change data of the equipment in the process of eluent extraction and the movement position change data of the equipment in the process of reaction of the liquid to be marked;

[0062] The embodiment of the present invention uses the time series change analysis technology to perform a detailed mobile position change analysis on the motion trajectory of the equipment in the eluent extraction process and the motion trajectory of the equipment in the reaction process of the liquid to be marked, so as to analyze and obtain the position changes of the corresponding equipment in the time series, and determine the specific position changes of its motion path, and finally obtain the motion position change data of the equipment in the eluent extraction process and the motion position change data of the equipment in the reaction process of the liquid to be marked.

[0063] Step S123: Analyze the direction change of the movement trajectory of the equipment in the process of eluent extraction and the movement trajectory of the equipment in the process of reaction of the liquid to be marked, and obtain the movement direction change data of the equipment in the process of eluent extraction and the movement direction change data of the equipment in the process of reaction of the liquid to be marked;

[0064] The embodiment of the present invention also uses the time series change analysis technology to perform a detailed change analysis on the motion trajectory of the equipment in the eluent extraction process and the moving direction within the motion trajectory of the equipment in the reaction process of the liquid to be marked, so as to analyze and obtain the angle or direction changes of the equipment at different time points, and finally obtain the motion direction change data of the equipment in the eluent extraction process and the motion direction change data of the equipment in the reaction process of the liquid to be marked.

[0065] Step S124: performing virtual positioning processing on the movement trajectory of the equipment during the eluent extraction process based on the movement position change data of the equipment during the eluent extraction process and the movement direction change data of the equipment during the eluent extraction process to obtain the initial positioning position of the eluent extraction process;

[0066] The embodiment of the present invention performs virtual positioning processing on the corresponding equipment motion trajectory of the eluent extraction process by combining the analyzed data on the change in motion position of the equipment during the eluent extraction process and the change in motion direction of the equipment during the eluent extraction process, so as to help accurately determine the initial positioning position of the corresponding equipment during the eluent extraction process, and ensure that the equipment can move according to the expected path, and finally obtain the initial positioning position of the eluent extraction process.

[0067] Step S125: Based on the movement position change data of the equipment in the reaction process of the liquid to be marked and the movement direction change data of the equipment in the reaction process of the liquid to be marked, a virtual positioning process is performed on the movement trajectory of the equipment in the reaction process of the liquid to be marked to obtain the initial positioning position of the reaction process of the injection of the liquid to be marked.

[0068] The embodiment of the present invention also performs virtual positioning processing on the corresponding motion trajectory of the equipment in the reaction process of the liquid to be marked by combining the analysis of the motion position change data of the equipment in the reaction process of the liquid to be marked and the motion direction change data of the equipment in the reaction process of the liquid to be marked, so as to help accurately determine the initial positioning position of the corresponding equipment in the reaction process of the liquid to be marked, and ensure the accuracy of the equipment position during the injection reaction process, and finally obtain the initial positioning position of the injection reaction process of the liquid to be marked.

[0069] The present invention firstly identifies and analyzes the motion trajectory of the device during the operation of the device in the automatic marking device of technetium-labeled drugs by performing device equipment motion trajectory recognition analysis on the eluent extraction simulation process and the injection reaction simulation process of the liquid to be marked. This analysis helps to understand the motion mode of the device, including the movement path and trajectory law of the device during the eluent extraction process and the injection reaction process of the marking liquid. Secondly, the position change analysis of the device motion trajectory during the eluent extraction process and the injection reaction process of the liquid to be marked is performed. Through this analysis, the position change data of the corresponding device during the virtual operation process can be obtained, so as to better understand the position adjustment and movement of the device, and provide data support for subsequent positioning processing. Then, the direction change analysis of the device motion trajectory during the eluent extraction process and the device motion trajectory during the reaction process of the liquid to be marked is performed to explore the direction change of the corresponding device during the virtual operation process. This analysis can help understand the movement direction change law of the device at different stages, and provide more comprehensive data support for the accurate positioning of the device motion trajectory. Next, the equipment motion trajectory of the eluent extraction process was virtually positioned based on the equipment motion position change data and motion direction change data during the eluent extraction process. This process can help accurately determine the initial positioning position of the corresponding equipment during the eluent extraction process, ensuring that the equipment can move along the expected path. Finally, similarly, the equipment motion trajectory of the marked liquid reaction process was virtually positioned based on the equipment motion position change data and motion direction change data during the marked liquid reaction process. This process can ensure the accurate positioning of the marked liquid injection reaction process, allowing the equipment to move along the established path, thereby ensuring the accuracy of the marking process.

[0070] Preferably, step S13 comprises the following steps:

[0071] Step S131: using the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic labeling device to respectively perform auxiliary practical inertia analysis on the initial positioning position of the eluent extraction process and the initial positioning position of the injection reaction process of the liquid to be labeled, to obtain the inertia data of the actual extraction process of the eluent and the inertia data of the actual injection reaction process of the liquid to be labeled;

[0072] The embodiment of the present invention uses the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic marking device to perform actual operation processing on the initial positioning position of the eluent extraction process and analyze the corresponding inertia conditions of its movement process, which involves observing and recording the behavior of the device in actual operation, including movement, stability, response speed, etc., so as to obtain the inertia data of the actual eluent extraction process. Similarly, by using the lifting plate and the iron column fixing mechanism in the automatic marking device to perform actual operation processing on the initial positioning position of the injection reaction process of the liquid to be marked and analyze the corresponding inertia conditions of its movement process, the actual inertia data of the injection reaction process of the liquid to be marked is obtained, and finally the inertia data of the actual injection reaction process of the liquid to be marked is obtained.

[0073] Step S132: performing extraction inertia offset calibration analysis on the initial positioning position of the eluent extraction process based on the inertia data of the actual eluent extraction process to obtain an inertia offset calibration value of the eluent extraction process;

[0074] The embodiment of the present invention analyzes the positioning position offset caused by inertia in the initial positioning position of the corresponding eluent extraction process by combining the inertial data of the actual eluent extraction process obtained by analysis, so as to identify and quantify the inertial offset in the extraction process, that is, the difference between the positioning position in the actual operation process and the expected position in the simulation process, and performs calibration calculations on it to determine the calibration value of the equipment movement positioning position during the eluent extraction process, and finally obtain the inertial offset calibration value of the eluent extraction process.

[0075] Step S133: performing positioning calibration processing on the initial positioning position of the eluent extraction process according to the inertial offset calibration value of the eluent extraction process to obtain the eluent extraction positioning position;

[0076] The embodiment of the present invention uses the inertial offset calibration value of the eluent extraction process obtained by analysis to calibrate the positioning position with inertial offset within the initial positioning position of the eluent extraction process, so as to adjust the control parameters or mechanical structure of the device to correct the inertial offset, thereby ensuring that the equipment can be accurately positioned during the extraction process and finally obtaining the eluent extraction positioning position.

[0077] Step S134: performing injection inertia offset calibration analysis on the initial positioning position of the injection reaction process of the liquid to be marked based on the inertia data of the actual injection reaction process of the liquid to be marked, and obtaining an inertia offset calibration value of the injection reaction process of the liquid to be marked;

[0078] The embodiment of the present invention analyzes the positioning position offset caused by inertia in the initial positioning position of the corresponding injection reaction process of the liquid to be marked by combining the inertia data of the actual injection reaction process of the liquid to be marked obtained by analysis, so as to identify and quantitatively analyze the inertia offset in the injection reaction process, and perform calibration calculation on it to determine the calibration value of the equipment moving positioning position in the injection reaction process of the liquid to be marked, and finally obtain the inertia offset calibration value of the injection reaction process of the liquid to be marked.

[0079] Step S135: performing positioning calibration processing on the initial positioning position of the reaction process of the injection of the liquid to be marked according to the inertial offset calibration value of the reaction process of the injection of the liquid to be marked, so as to obtain the reaction positioning position of the injection of the liquid to be marked.

[0080] The embodiment of the present invention uses the inertial offset calibration value obtained by analysis during the injection reaction process of the liquid to be marked to calibrate the device positioning position corresponding to the inertial offset situation within the initial positioning position of the injection reaction process of the liquid to be marked, so as to adjust the control parameters or mechanical structure of the device to correct the inertial offset, thereby ensuring that the device can be accurately positioned during the injection reaction process, and finally obtaining the positioning position of the injection reaction of the liquid to be marked.

[0081] The present invention firstly uses the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic marking device to respectively perform auxiliary practical inertia analysis on the initial positioning position of the eluent extraction process and the initial positioning position of the injection reaction process of the liquid to be marked, so as to obtain the actual operation inertia data of the eluent extraction process and the injection reaction process of the liquid to be marked. This analysis can help understand the inertial performance of the equipment in actual operation, thereby providing a reliable data basis for subsequent calibration and positioning processing. Secondly, based on the inertial data of the actual extraction process of the eluent, the initial positioning position of the eluent extraction process is subjected to extraction inertia offset calibration analysis to determine the inertial offset calibration value of the eluent extraction process. This analysis helps to understand the inertial offset of the corresponding equipment in the actual extraction operation process, so that corresponding calibration measures can be taken to improve the accuracy of equipment positioning. Then, the initial positioning position of the eluent extraction process is subjected to positioning calibration processing according to the inertial offset calibration value of the eluent extraction process obtained by the analysis, so as to obtain an accurate eluent extraction positioning position. This step is to ensure that the equipment can be accurately positioned during the extraction process, thereby ensuring the smooth progress of the operation and the accuracy of the results. Next, similarly, the injection inertia offset calibration analysis is performed on the initial positioning position of the injection reaction process of the liquid to be marked based on the inertia data of the actual injection reaction process of the liquid to be marked, so as to determine the inertia offset calibration value of the injection reaction process of the liquid to be marked. This analysis helps to understand the inertia offset in the injection process of the liquid to be marked, and provides a basis for subsequent positioning calibration. Finally, the initial positioning position of the injection reaction process of the liquid to be marked is calibrated according to the inertia offset calibration value of the injection reaction process of the liquid to be marked, so as to obtain the accurate positioning position of the injection reaction of the liquid to be marked. This step can ensure the accurate positioning of the equipment during the injection process of the liquid to be marked, thereby ensuring the successful progress of the marking process.

[0082] Preferably, step S2 comprises the following steps:

[0083] Step S21: Based on the extraction and positioning position of the eluent, the retractable structure of the lead shielding material in the technetium-labeled drug automatic marking device is automatically positioned on the elution tank accommodating component through the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic marking device, and the elution tank accommodating component is shielded in the retractable structure of the lead shielding material;

[0084] The embodiment of the present invention uses the lifting plate and iron column fixing mechanism in the technetium-labeled drug automatic marking device to accurately position and adjust the retractable structure of the lead shielding material in the technetium-labeled drug automatic marking device onto the elution tank containing component according to the positioning position obtained by combining the eluent extraction positioning position analyzed, and then, the retractable structure of the lead shielding material is adjusted to completely wrap the elution tank containing component inside to achieve shielding thereof.

[0085] Step S22: driving the syringe barrel to move to the inside of the elution tank accommodating component through the turntable of the syringe barrel in the lead shielding material retractable structure, and driving the Hall flowmeter through the piston connecting rod of the syringe barrel to extract and record the sodium pertechnetate eluent in the elution tank accommodating component to generate a sodium pertechnetate eluent extraction process;

[0086] The embodiment of the present invention drives the entire syringe barrel to move into the elution tank containing part by using the turntable of the syringe barrel in the telescopic structure of the lead shielding material and controlling its rotation speed and direction, and drives the Hall flowmeter to extract the sodium pertechnetate eluent in the elution tank containing part by using the piston connecting rod in the syringe barrel, and records the entire extraction process, thereby ensuring the accurate extraction and recording of the eluent, and finally generating the sodium pertechnetate eluent extraction process.

[0087] Step S23: using the eluent activity calculation formula in the cylinder to perform activity statistics calculation on each time point of the sodium pertechnetate eluent extraction process to obtain the eluent activity value in the cylinder at each time point;

[0088] The embodiment of the present invention combines time point measurement parameters, time range variable parameters, the initial concentration of the sodium pertechnetate eluent, the decay rate parameters of the active components in the sodium pertechnetate eluent and related parameters to form a suitable calculation formula for the activity of the eluent in the cylinder, and performs activity statistical calculations at various time points in the sodium pertechnetate eluent extraction process to quantitatively determine the eluent activity of the eluent in the Hall flowmeter at different extraction time points, and finally obtain the activity value of the eluent in the cylinder at each time point.

[0089] Step S24: comparing and judging the activity value of the eluent in the cylinder at each time point according to the preset standard value of the activity of the eluent; if the activity value of the eluent in the cylinder at the first time point is greater than or equal to the preset standard value of the activity of the eluent, then setting the corresponding time point as the quantitative extraction control point; if the activity value of the eluent in the cylinder at the first time point is less than the preset standard value of the activity of the eluent, then continue to compare and judge the activity value of the eluent in the cylinder at the next time point until it is greater than or equal to the preset standard value of the activity of the eluent;

[0090] The embodiment of the present invention compares and judges the activity values ​​of the eluent in the cylinder at each time point obtained by quantitative calculation by using a preset eluent activity standard value. If it is judged that the activity value of the eluent in the cylinder at the first time point is greater than or equal to the preset eluent activity standard value, it means that the eluent activity at this time point has reached the expected level, and the extraction of the corresponding eluent can be stopped, and the corresponding time point can be set as the quantitative extraction control point; if it is judged that the activity value of the eluent in the cylinder at the first time point is less than the preset eluent activity standard value, it means that the eluent activity at this time point has not reached the expected level, and it is necessary to continue extraction, and continue to compare and judge the activity value of the eluent in the cylinder at the next time point until it is greater than or equal to the preset eluent activity standard value and then stop.

[0091] Step S25: Based on the quantitative extraction control point, the extraction process of the sodium pertechnetate eluent is quantitatively controlled, and the syringe barrel is driven to move to the original position by the turntable to obtain a quantitative sodium pertechnetate eluent.

[0092] The embodiment of the present invention performs quantitative control on the corresponding sodium pertechnetate eluent extraction process by combining the quantitative extraction control points obtained through analysis, thereby ensuring that the technetium content in the eluent in the Hall flowmeter reaches the expected target. At the same time, the turntable drives the syringe barrel to move to the original position to end the entire eluent extraction process, and finally obtains a quantitative sodium pertechnetate-containing eluent.

[0093] The present invention firstly uses the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic marking device to automatically position the lead shielding material retractable structure in the technetium-labeled drug automatic marking device to the elution tank containing part by combining the eluent extraction positioning position obtained by pre-positioning, so as to realize the accurate positioning of the entire lead shielding material retractable structure in the automatic marking device, thereby ensuring the accuracy and stability of subsequent operations. At the same time, by using the lifting plate and the iron column fixing mechanism to accurately position the lead shielding material retractable structure on the elution tank containing part, and shielding the elution tank containing part therein, a stable working environment and safety guarantee are provided for the subsequent injection process. Secondly, the syringe barrel is driven to move to the inside of the elution tank receiving part by using the turntable of the syringe barrel in the retractable structure of the lead shielding material, and the piston connecting rod of the syringe barrel drives the Hall flowmeter to extract and record the sodium pertechnetate eluent in the elution tank receiving part. This step not only realizes the accurate extraction and recording of the eluent, but also drives the movement of the syringe barrel by the turntable, which can ensure that the syringe barrel accurately extracts the corresponding sodium pertechnetate eluent in the elution tank receiving part, thereby providing a reliable data basis for subsequent activity calculations. Then, the activity of the sodium pertechnetate eluent is statistically calculated at each time point during the extraction process of the sodium pertechnetate eluent by using the eluent activity calculation formula in the barrel. This process can accurately evaluate the activity change of technetium in the barrel during the extraction of the eluent, thereby providing an important reference for the subsequent activity control to stop the extraction. Next, the activity values ​​of the eluent in the cylinder at each time point are compared and judged according to the preset standard value of the eluent activity, and the corresponding quantitative extraction control point is set to achieve the quantitative stop of the eluent extraction process. The key to this step is to ensure that the activity of the eluent in the cylinder reaches the expected level based on the comparison of the actual activity value with the preset standard value, and then stop extracting the corresponding eluent, thereby providing an important basis and guarantee for the subsequent quantitative extraction process. Finally, by performing quantitative extraction control processing on the sodium pertechnetate eluent based on the quantitative extraction control point, this step can ensure that the technetium content in the eluent reaches the expected target. At the same time, the turntable drives the syringe barrel to move to the original position to end the entire eluent extraction process, which can achieve the integrity and accuracy of the extraction process, thereby providing a reliable basis and data support for subsequent experimental operations.

[0094] Preferably, the formula for calculating the activity of the eluent in the cylinder in step S23 is specifically:

[0095]

[0096] Where A(t) is the activity value of the eluent in the cylinder at time point t, t is the time point measurement parameter, T is the time range variable parameter, N is the initial activity of the sodium pertechnetate eluent, k is the decay rate parameter of the active component in the sodium pertechnetate eluent, and ε is the correction coefficient of the activity value of the eluent in the cylinder.

[0097] The present invention obtains a calculation formula for the activity of the eluent in the cylinder by using a specific mathematical model and verifying that the calculation formula is used for statistical calculation of the activity at each time point of the sodium pertechnetate eluent extraction process. The calculation formula for the activity of the eluent in the cylinder adopts an integral solution method to cumulatively calculate the activity of the eluent between time points 0 and T. This method can comprehensively consider the change of the activity of the eluent in the time period and more accurately reflect the overall change trend of the activity of the eluent. The main goal of the calculation formula is to determine the activity of the sodium pertechnetate eluent at different time points in order to evaluate the activity change of the drug during the extraction process. Through the statistical calculation of the activity, the attenuation of the eluent during the extraction process can be understood, thereby providing a basis for subsequent operations and processing. By using this calculation formula, the activity of the sodium pertechnetate eluent during the extraction process can be quantitatively evaluated, so that according to the change of the activity, the stability and activity change of the drug can be judged, thereby determining the optimal extraction time point. In addition, a correction factor is introduced into the formula to adjust the calculation results to make them more consistent with the actual situation. This correction factor can be adjusted according to actual data and experience, thereby improving the accuracy and applicability of the calculation results. By calculating at different time points, the change of eluent activity over time can be obtained, so as to fully understand the change of eluent activity. In summary, the calculation formula for the activity of the eluent in the cylinder comprehensively considers multiple factors such as time factors and active component attenuation. Through integral solution and the introduction of correction coefficients, the activity value of the eluent in the cylinder at each time point can be accurately calculated, thereby providing an important basis for the subsequent eluent extraction process. Therefore, this formula can fully consider the activity value A(t) of the eluent in the cylinder at the time point t, the time point measurement parameter t, the time range variable parameter T, the initial activity N of the sodium pertechnetate eluent, the decay rate parameter k of the active component in the sodium pertechnetate eluent, and the correction coefficient ε of the activity value of the eluent in the cylinder. According to the correlation between the activity value A(t) of the eluent in the cylinder at the time point t and the above parameters, a functional relationship is formed. The formula can realize the statistical calculation process of the activity of sodium pertechnetate eluent at each time point during the extraction process. At the same time, the correction coefficient ε of the activity value of the eluent in the cylinder can be introduced to make adjustments according to the errors occurring in the calculation process, thereby improving the accuracy and applicability of the calculation formula for the activity of the eluent in the cylinder.

[0098] Preferably, step S3 comprises the following steps:

[0099] Step S31: based on the injection reaction positioning position of the liquid to be marked, the retractable lead shielding material structure in the automatic marking device for technetium-labeled drugs is automatically positioned on the marking tank accommodating component through the lifting plate and the iron column fixing mechanism in the automatic marking device for technetium-labeled drugs, and the marking tank accommodating component is shielded in the retractable lead shielding material structure;

[0100] The embodiment of the present invention first uses the lifting plate and iron column fixing mechanism in the technetium-labeled drug automatic marking device to accurately position and adjust the retractable structure of the lead shielding material in the technetium-labeled drug automatic marking device onto the marking tank containing component according to the positioning position by combining the injection reaction positioning position of the liquid to be marked obtained by analysis, and then, the retractable structure of the lead shielding material is adjusted to completely wrap the marking tank containing component inside to achieve shielding thereof and ensure that radiation will not leak into the surrounding environment during the subsequent marking process.

[0101] Step S32: driving the syringe barrel to move to the inside of the labeling tank containing part through the rotating disk of the syringe barrel, and injecting a quantitative amount of sodium pertechnetate-containing eluent into the labeling tank containing part through the automatic pusher;

[0102] The embodiment of the present invention controls the rotation speed and direction of the turntable in the syringe barrel to drive the entire syringe barrel to move into the marking tank containing part, and injects the quantitative sodium pertechnetate eluent in the Hall flowmeter into the marking tank containing part by using an automatic propeller.

[0103] Step S33: The technetium-labeled drug automatic labeling device performs reaction labeling processing and records the quantitative sodium pertechnetate-containing eluent and the drug solution to be labeled according to a preset automatic labeling control program to generate a technetium-labeled drug reaction preparation labeling process.

[0104] The embodiment of the present invention uses an automatic marking control program (including the setting of parameters such as the time, temperature, and pressure of the marking reaction) pre-set by a processor in an automatic marking device for marking drugs with technetium to react with a quantitative sodium pertechnetate-containing eluent and a drug solution to be marked in a marking tank containing component, and records the entire marking process, and finally records the marking process of generating a reaction to prepare the technetium-labeled drug.

[0105] The present invention firstly uses the lifting plate and the iron column fixing mechanism in the automatic marking device for marking drugs of technetium to automatically position the retractable structure of the lead shielding material in the automatic marking device for marking drugs on the marking tank containing part by combining the injection reaction positioning position of the liquid to be marked obtained by analysis, and ensures that the marking tank containing part is completely shielded in the retractable structure of the lead shielding material. Such a design ensures the radiation safety and the accuracy of the operation during the marking process, thereby providing a reliable basis for the subsequent marking steps. Then, the syringe barrel is accurately moved to the inside of the marking tank containing part by the turntable of the syringe barrel, and the quantitative sodium pertechnetate-containing eluent is accurately injected into the marking tank containing part by the automatic propeller. The key to this step is that it can ensure the accurate injection of the sodium pertechnetate-containing eluent and the precise control of the liquid in the marking tank containing part, thereby providing a reliable liquid basis for the subsequent marking process. Finally, the technetium-labeled drug automatic labeling device is used to perform reaction labeling on the quantitative sodium pertechnetate-containing eluent and the drug solution to be labeled according to the preset automatic labeling control program, and the entire labeling process is recorded. The key to this step is that it can realize automated labeling processing, ensuring the accuracy and consistency of the labeling, and recording the entire reaction process, thereby providing important data support for subsequent quality control and result analysis.

[0106] Preferably, step S4 comprises the following steps:

[0107] Step S41: performing a statistical analysis on the reaction time of the technetium-labeled drug reaction preparation labeling process to obtain the duration of the technetium-labeled drug reaction preparation;

[0108] The embodiment of the present invention uses a reaction time recorder to perform statistical analysis of the reaction time of the entire technetium-labeled drug reaction preparation labeling process, and continuously records the reaction start time and end time to statistically analyze the duration of the technetium-labeled drug reaction preparation, that is, the time period from the start of the reaction to the end of the reaction, and finally obtains the duration of the technetium-labeled drug reaction preparation.

[0109] Step S42: monitoring and analyzing the reaction degree of the technetium-labeled drug reaction preparation and labeling process to obtain the reaction state degree of the technetium-labeled drug;

[0110] The embodiment of the present invention uses appropriate reaction monitoring equipment including but not limited to a spectrophotometer, a high performance liquid chromatograph (HPLC), a radioactivity counter, etc. to monitor the reaction degree in real time during the preparation and labeling process of the technetium-labeled drug reaction, so as to monitor the change in the wavelength of the absorption spectrum in real time to evaluate and analyze the state degree of the drug reaction during the reaction process, that is, the degree and change trend of the drug labeling reaction process, and finally obtain the state degree of the technetium-labeled drug reaction.

[0111] Step S43: Based on the duration of the technetium-labeled drug reaction preparation and the degree of the technetium-labeled drug reaction state, a radiation level statistical calculation is performed on the technetium-labeled drug reaction preparation labeling process using a reaction radiation level calculation formula to obtain a radiation level value of the technetium-labeled drug reaction process;

[0112] The embodiment of the present invention combines the duration of technetium-labeled drug reaction preparation, reaction time variable parameters, the initial concentration of radioactive material, the degree of technetium-labeled drug reaction state, the size of the radiation reaction system, the half-life of the radioactive material, the specific activity of the radioactive material, the radiation energy absorption rate, the attenuation coefficient of the radioactive material, the reaction environment absorption rate and related parameters to form a suitable reaction radiation level calculation formula to perform statistical calculation of the radiation level in the technetium-labeled drug reaction preparation and labeling process, so as to quantitatively calculate the radiation level in the reaction process and finally obtain the radiation level value of the technetium-labeled drug reaction process.

[0113] Step S44: performing correlation mining analysis on the thickness level of the retractable structure of the lead shielding material in the technetium-labeled drug automatic labeling device based on the radiation level value of the technetium-labeled drug reaction process, so as to obtain the correlation relationship between the radiation level of the reaction process and the thickness level of the shielding structure;

[0114] The embodiment of the present invention uses an associated mining analysis algorithm to mine and analyze the thickness level parameters of the retractable structure of the lead shielding material in the automatic marking device for technetium-labeled drugs by combining the radiation level values ​​of the reaction process of technetium-labeled drugs obtained by analysis, so as to explore and analyze the linear correlation between the reaction radiation level and the thickness of the shielding structure, which is used to adjust the thickness level of the shielding structure accordingly, and finally obtain the correlation between the radiation level of the reaction process and the thickness level of the shielding structure.

[0115] Step S45: Based on the correlation between the radiation level of the reaction process and the thickness level of the shielding structure, the technetium-labeled drug reaction preparation marking process is adaptively controlled by the retractable structure of the lead shielding material in the technetium-labeled drug automatic marking device until the technetium-labeled drug reaction preparation marking process is completed to obtain the technetium-labeled drug reaction result product.

[0116] The embodiment of the present invention uses an adaptive control algorithm to set an adaptive radiation shielding control strategy for the retractable structure of the lead shielding material in the automatic marking device for technetium-labeled drugs by combining the correlation relationship between the radiation level of the reaction process and the thickness level of the shielding structure obtained by analysis, including dynamically adjusting the thickness level parameters of the lead shielding material according to the real-time radiation level value in the structure, so as to achieve effective shielding control of the radiation in the reaction process, and ensure that the radiation level in the technetium-labeled drug reaction preparation and marking process can be effectively shielded and controlled until the technetium-labeled drug reaction preparation and marking process is completed, and finally the technetium-labeled drug reaction result finished product is obtained.

[0117] The present invention firstly performs a statistical analysis of the reaction time of the technetium-labeled drug reaction preparation and marking process, which can ensure that the duration of the reaction of the marking process is accurately recorded and analyzed. This step can determine the time consumption of each stage in the marking process through the statistical analysis of the reaction time, which is helpful to optimize the operation process and improve the marking efficiency, thereby providing important data support for subsequent quality control and process improvement, and ensuring the controllability and stability of the marking process. Secondly, by monitoring and analyzing the reaction degree of the technetium-labeled drug reaction preparation and marking process, the purpose of this step is to accurately evaluate the degree of reaction. By monitoring the reaction state, the progress of the reaction can be understood in real time, and the operating parameters can be adjusted in time to ensure the successful progress of the marking process. It can also improve the monitoring and control capabilities of the marking process, which helps to avoid possible failures and quality problems, thereby ensuring the accuracy and consistency of the marking results. Then, based on the duration of the technetium-labeled drug reaction preparation and the degree of reaction state, the reaction radiation level calculation formula is used to perform a statistical calculation of the radiation level of the marking process. The key to this step is that the radiation risk in the marking process can be comprehensively evaluated through the statistical calculation of the radiation level, providing a scientific basis for subsequent radiation safety management. Next, the thickness level of the retractable structure of the lead shielding material is analyzed by correlation mining based on the radiation level value of the reaction process to explore the relationship between the radiation level of the reaction process and the thickness of the shielding structure. The key to this step is to adjust the thickness level of the shielding structure according to the accurate assessment of the radiation level in the shielding structure to improve the radiation shielding effect, thereby ensuring the safety of operators and the environment. Finally, the retractable structure of the lead shielding material is used to perform adaptive radiation shielding control on the marking process based on the correlation between the radiation level of the reaction process and the thickness of the shielding structure. The key to this step is to achieve targeted radiation shielding control to minimize the impact of radiation levels on the environment and operators, while ensuring the smooth progress of the marking process and the stable quality of the marking results.

[0118] Preferably, the reaction radiation level calculation formula in step S43 is specifically:

[0119]

[0120] Wherein, R is the radiation level value of the technetium-labeled drug reaction process, T' is the duration of the technetium-labeled drug reaction preparation, τ is the reaction time variable parameter, v0 is the initial concentration of the radioactive substance in the technetium-labeled drug reaction preparation and labeling process, S is the degree of the technetium-labeled drug reaction state, N is the size of the radiation reaction system, ρ1 is the half-life of the radioactive substance, ρ2 is the specific activity of the radioactive substance, θ1 is the radiation energy absorption rate, θ2 is the attenuation coefficient of the radioactive substance, θ3 is the reaction environment absorption rate, and η is the correction coefficient of the radiation level value of the technetium-labeled drug reaction process.

[0121] The present invention obtains a reaction radiation level calculation formula by using a specific mathematical model and verifying it, which is used to perform statistical calculation of the radiation level in the process of preparing and labeling the reaction of technetium-labeled drugs. The reaction radiation level calculation formula also uses an integral solution method to cumulatively calculate the radiation level between the reaction time 1 and T' (reaction duration). This method can comprehensively consider the change of the radiation level in the entire reaction process and more accurately reflect the overall radiation level of the reaction process. The v0 in the formula represents the initial concentration of the radioactive substance in the process of preparing and labeling the reaction of technetium-labeled drugs. This item considers the concentration of the radioactive substance at the beginning of the reaction and is one of the important factors for calculating the radiation level. Secondly, N in the formula represents the size of the radiation reaction system. This parameter reflects the scale of the reaction system and has an important influence on the calculation of the radiation level, because a larger reaction system may produce a higher radiation level. Then, the formula also includes parameters such as the half-life (ρ1) and specific activity (ρ2) of the radioactive substance. These parameters describe the characteristics of the radioactive substance and play a key role in calculating the radiation level. θ1, θ2, and θ3 in the formula represent the radiation energy absorption rate, the attenuation coefficient of the radioactive material, and the reaction environment absorption rate, respectively. These factors take into account the propagation and absorption of radiation in the environment, and have an important influence on the calculation of the actual radiation level during the reaction. In addition, a correction factor is introduced into the formula to adjust the calculation results to make them more in line with the actual situation. This correction factor can be adjusted according to actual data and experience, thereby improving the accuracy and applicability of the calculation results. In summary, the reaction radiation level calculation formula comprehensively considers multiple factors such as reaction duration, reaction degree monitoring, radioactive material characteristics, and environmental factors. Through integral solution and the introduction of correction coefficients, the radiation level value of the technetium-labeled drug reaction process can be accurately calculated, thereby providing an important basis for subsequent shielding control. Therefore, this formula can fully consider the radiation level value R of the technetium-labeled drug reaction process, the duration of the technetium-labeled drug reaction preparation T', the reaction time variable parameter τ, the initial concentration v0 of the radioactive substance in the technetium-labeled drug reaction preparation labeling process, the technetium-labeled drug reaction state degree S, the size N of the radiation reaction system, the half-life ρ1 of the radioactive substance, the specific activity ρ2 of the radioactive substance, the radiation energy absorption rate θ1, the attenuation coefficient θ2 of the radioactive substance, the reaction environment absorption rate θ3, and the correction coefficient η of the radiation level value of the technetium-labeled drug reaction process. According to the mutual correlation between the radiation level value R of the technetium-labeled drug reaction process and the above parameters, a functional relationship is formed. The formula can realize the statistical calculation process of the radiation level in the preparation and labeling process of the technetium-labeled drug reaction. At the same time, by introducing the correction coefficient η of the radiation level value in the technetium-labeled drug reaction process, it can be adjusted according to the errors occurring in the calculation process, thereby improving the accuracy and applicability of the reaction radiation level calculation formula.

[0122] Preferably, the present invention also provides a lead shielding-based technetium-labeled drug automatic labeling device, referring to Figure 4 As shown, it includes a processor 91, a memory 92, a control panel 9, a retractable structure 1 of lead shielding material, a syringe barrel 2, a accommodating component 3, an accommodating connection structure 4, a rotating connection mechanism 5, a gear with a slot 6, a lifting plate 7, an iron column fixing mechanism 8 and a computer program stored in the memory 92 and executable on the processor 91, for executing the automatic marking method of technetium-labeled drugs based on lead shielding as described above, the accommodating component 3 is connected to the control panel 9 through the accommodating connection structure 4, the accommodating component 3 includes a rinsing tank accommodating component 31 and a marking tank accommodating component 32, the syringe barrel 2 includes a piston connecting rod 21, a Hall flowmeter 22, a turntable 23 and an automatic propeller 24, the retractable structure 1 of lead shielding material and the syringe barrel 2 inside it are connected to the right side of the gear with a slot 6 through the rotating connection mechanism 5, the control panel 9 and the accommodating component 3 are connected through the iron column fixing mechanism 8, and are connected to the left side of the gear with a slot 6 through the lifting plate 7, and the processor 91 and the memory 92 are configured in the control panel 9.

[0123] Therefore, the embodiments should be regarded as illustrative and non-restrictive from all points, and the scope of the present invention is limited by the appended claims rather than the above description, and it is therefore intended that all changes falling within the meaning and range of equivalent elements of the application documents are included in the present invention.

[0124] The above description is only a specific embodiment of the present invention, so that those skilled in the art can understand or implement the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but should conform to the widest scope consistent with the principles and novel features invented herein.

Claims

1. A method for automatic labeling of technetium-labeled drugs based on lead shielding, characterized in that: The invention is applied to an automatic marking device for technetium-labeled drugs based on lead shielding, and the automatic marking method for technetium-labeled drugs based on lead shielding comprises the following steps: Step S1: A rinsing tank containing part and a marking tank containing part are assisted in positioning by a technetium-labeled drug automatic marking device to obtain a rinsing liquid extraction positioning position and a to-be-labeled liquid injection reaction positioning position; a sodium pertechnetate rinsing liquid containing technetium-99m radioactive isotope and a to-be-labeled drug solution are respectively stored in the rinsing tank containing part and the marking tank containing part in the technetium-labeled drug automatic marking device; Step S2: Based on the extraction location of the eluent, the eluent is shielded and quantitatively extracted from the eluent containing part of the eluent tank by a technetium-labeled drug automatic labeling device to obtain a quantitative sodium pertechnetate-containing eluent; Step S3: automatically positioning the retractable structure of the lead shielding material in the automatic marking device for technetium-labeled drugs on the labeling tank containing part based on the injection reaction positioning position of the liquid to be labeled, and injecting a quantitative sodium pertechnetate-containing eluent into the labeling tank containing part through the syringe barrel; performing reaction labeling treatment and recording on the quantitative sodium pertechnetate-containing eluent and the drug solution to be labeled by the automatic marking device for technetium-labeled drugs, so as to generate a technetium-labeled drug reaction preparation labeling process; Step S4: Perform statistical calculation of the radiation level of the technetium-labeled drug reaction preparation and marking process to obtain the radiation level value of the technetium-labeled drug reaction process; based on the radiation level value of the technetium-labeled drug reaction process, perform intelligent control of the radiation shielding reaction of the technetium-labeled drug reaction preparation and marking process through a technetium-labeled drug automatic marking device to obtain the finished product of the technetium-labeled drug reaction result.

2. The method for automatic labeling of technetium-labeled drugs based on lead shielding according to claim 1, characterized in that: Step S1 includes the following steps: Step S11: using the technetium-labeled drug automatic labeling device to simulate and analyze the device use process of the elution tank containing component and the labeling tank containing component, and obtain the elution liquid extraction simulation process and the labeled liquid injection reaction simulation process; Step S12: performing virtual positioning processing on the eluent extraction simulation process and the marked liquid injection reaction simulation process to obtain the initial positioning position of the eluent extraction process and the initial positioning position of the marked liquid injection reaction process; Step S13: using the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic labeling device to respectively perform auxiliary positioning calibration analysis on the initial positioning position of the eluent extraction process and the initial positioning position of the injection reaction process of the liquid to be labeled, so as to obtain the eluent extraction positioning position and the injection reaction positioning position of the liquid to be labeled; Step S14: storing the sodium pertechnetate eluent containing technetium-99m radioactive isotope in the eluent tank containing component in the technetium-labeled drug automatic labeling device; Step S15: storing the drug solution to be labeled in a labeling tank containing component in the technetium-labeled drug automatic labeling device.

3. The method for automatic labeling of technetium-labeled drugs based on lead shielding according to claim 2, characterized in that: Step S12 includes the following steps: Step S121: performing device motion trajectory recognition and analysis on the eluent extraction simulation process and the labeled liquid injection reaction simulation process to obtain the device motion trajectory of the eluent extraction process and the device motion trajectory of the labeled liquid reaction process; Step S122: analyzing the position change of the movement trajectory of the equipment in the process of eluent extraction and the movement trajectory of the equipment in the process of reaction of the liquid to be marked, and obtaining the movement position change data of the equipment in the process of eluent extraction and the movement position change data of the equipment in the process of reaction of the liquid to be marked; Step S123: Analyze the direction change of the movement trajectory of the equipment in the process of eluent extraction and the movement trajectory of the equipment in the process of reaction of the liquid to be marked, and obtain the movement direction change data of the equipment in the process of eluent extraction and the movement direction change data of the equipment in the process of reaction of the liquid to be marked; Step S124: performing virtual positioning processing on the movement trajectory of the equipment during the eluent extraction process based on the movement position change data of the equipment during the eluent extraction process and the movement direction change data of the equipment during the eluent extraction process to obtain the initial positioning position of the eluent extraction process; Step S125: Based on the movement position change data of the equipment in the reaction process of the liquid to be marked and the movement direction change data of the equipment in the reaction process of the liquid to be marked, a virtual positioning process is performed on the movement trajectory of the equipment in the reaction process of the liquid to be marked to obtain the initial positioning position of the reaction process of the injection of the liquid to be marked.

4. The method for automatic labeling of technetium-labeled drugs based on lead shielding according to claim 2, characterized in that: Step S13 includes the following steps: Step S131: using the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic labeling device to respectively perform auxiliary practical inertia analysis on the initial positioning position of the eluent extraction process and the initial positioning position of the injection reaction process of the liquid to be labeled, to obtain the inertia data of the actual extraction process of the eluent and the inertia data of the actual injection reaction process of the liquid to be labeled; Step S132: performing extraction inertia offset calibration analysis on the initial positioning position of the eluent extraction process based on the inertia data of the actual eluent extraction process to obtain an inertia offset calibration value of the eluent extraction process; Step S133: performing positioning calibration processing on the initial positioning position of the eluent extraction process according to the inertial offset calibration value of the eluent extraction process to obtain the eluent extraction positioning position; Step S134: performing injection inertia offset calibration analysis on the initial positioning position of the injection reaction process of the liquid to be marked based on the inertia data of the actual injection reaction process of the liquid to be marked, and obtaining an inertia offset calibration value of the injection reaction process of the liquid to be marked; Step S135: performing positioning calibration processing on the initial positioning position of the reaction process of the injection of the liquid to be marked according to the inertial offset calibration value of the reaction process of the injection of the liquid to be marked, so as to obtain the reaction positioning position of the injection of the liquid to be marked.

5. The method for automatic labeling of technetium-labeled drugs based on lead shielding according to claim 1, characterized in that: Step S2 includes the following steps: Step S21: Based on the extraction and positioning position of the eluent, the retractable structure of the lead shielding material in the technetium-labeled drug automatic marking device is automatically positioned on the elution tank accommodating component through the lifting plate and the iron column fixing mechanism in the technetium-labeled drug automatic marking device, and the elution tank accommodating component is shielded in the retractable structure of the lead shielding material; Step S22: driving the syringe barrel to move to the inside of the elution tank accommodating component through the turntable of the syringe barrel in the lead shielding material retractable structure, and driving the Hall flowmeter through the piston connecting rod of the syringe barrel to extract and record the sodium pertechnetate eluent in the elution tank accommodating component to generate a sodium pertechnetate eluent extraction process; Step S23: using the eluent activity calculation formula in the cylinder to perform activity statistics calculation on each time point of the sodium pertechnetate eluent extraction process to obtain the eluent activity value in the cylinder at each time point; Step S24: comparing and judging the activity value of the eluent in the cylinder at each time point according to the preset standard value of the activity of the eluent; if the activity value of the eluent in the cylinder at the first time point is greater than or equal to the preset standard value of the activity of the eluent, then setting the corresponding time point as the quantitative extraction control point; if the activity value of the eluent in the cylinder at the first time point is less than the preset standard value of the activity of the eluent, then continue to compare and judge the activity value of the eluent in the cylinder at the next time point until it is greater than or equal to the preset standard value of the activity of the eluent; Step S25: Based on the quantitative extraction control point, the extraction process of the sodium pertechnetate eluent is quantitatively controlled, and the syringe barrel is driven to move to the original position by the turntable to obtain a quantitative sodium pertechnetate eluent.

6. The method for automatic labeling of technetium-labeled drugs based on lead shielding according to claim 5, characterized in that: The specific calculation formula of the eluent activity in the cylinder in step S23 is: Where A(t) is the activity value of the eluent in the cylinder at time point t, t is the time point measurement parameter, T is the time range variable parameter, N is the initial activity of the sodium pertechnetate eluent, k is the decay rate parameter of the active component in the sodium pertechnetate eluent, and ε is the correction coefficient of the activity value of the eluent in the cylinder.

7. The method for automatic labeling of technetium-labeled drugs based on lead shielding according to claim 1, characterized in that: Step S3 includes the following steps: Step S31: based on the injection reaction positioning position of the liquid to be marked, the retractable lead shielding material structure in the automatic marking device for technetium-labeled drugs is automatically positioned on the marking tank accommodating component through the lifting plate and the iron column fixing mechanism in the automatic marking device for technetium-labeled drugs, and the marking tank accommodating component is shielded in the retractable lead shielding material structure; Step S32: driving the syringe barrel to move to the inside of the labeling tank containing part through the rotating disk of the syringe barrel, and injecting a quantitative amount of sodium pertechnetate-containing eluent into the labeling tank containing part through the automatic pusher; Step S33: The technetium-labeled drug automatic labeling device performs reaction labeling processing and records the quantitative sodium pertechnetate-containing eluent and the drug solution to be labeled according to a preset automatic labeling control program to generate a technetium-labeled drug reaction preparation labeling process.

8. The method for automatic labeling of technetium-labeled drugs based on lead shielding according to claim 1, characterized in that: Step S4 includes the following steps: Step S41: performing a statistical analysis on the reaction time of the technetium-labeled drug reaction preparation labeling process to obtain the duration of the technetium-labeled drug reaction preparation; Step S42: monitoring and analyzing the reaction degree of the technetium-labeled drug reaction preparation and labeling process to obtain the reaction state degree of the technetium-labeled drug; Step S43: Based on the duration of the technetium-labeled drug reaction preparation and the degree of the technetium-labeled drug reaction state, a radiation level statistical calculation is performed on the technetium-labeled drug reaction preparation labeling process using a reaction radiation level calculation formula to obtain a radiation level value of the technetium-labeled drug reaction process; Step S44: performing correlation mining analysis on the thickness level of the retractable structure of the lead shielding material in the technetium-labeled drug automatic labeling device based on the radiation level value of the technetium-labeled drug reaction process, so as to obtain the correlation relationship between the radiation level of the reaction process and the thickness level of the shielding structure; Step S45: Based on the correlation between the radiation level of the reaction process and the thickness level of the shielding structure, the technetium-labeled drug reaction preparation marking process is adaptively controlled by the retractable structure of the lead shielding material in the technetium-labeled drug automatic marking device until the technetium-labeled drug reaction preparation marking process is completed to obtain the technetium-labeled drug reaction result product.

9. The method for automatic labeling of technetium-labeled drugs based on lead shielding according to claim 8, characterized in that: The specific calculation formula of the reaction radiation level in step S43 is: Wherein, R is the radiation level value of the technetium-labeled drug reaction process, T' is the duration of the technetium-labeled drug reaction preparation, τ is the reaction time variable parameter, v0 is the initial concentration of the radioactive substance in the technetium-labeled drug reaction preparation and labeling process, S is the degree of the technetium-labeled drug reaction state, N is the size of the radiation reaction system, ρ1 is the half-life of the radioactive substance, ρ2 is the specific activity of the radioactive substance, θ1 is the radiation energy absorption rate, θ2 is the attenuation coefficient of the radioactive substance, θ3 is the reaction environment absorption rate, and η is the correction coefficient of the radiation level value of the technetium-labeled drug reaction process.

10. An automatic labeling device for technetium-labeled drugs based on lead shielding, characterized in that: The invention comprises a processor, a memory, a control panel, a retractable structure of lead shielding material, a syringe barrel, a accommodating component, a accommodating connection structure, a rotating connection mechanism, a gear with a slot, a lifting plate, an iron column fixing mechanism and a computer program stored in the memory and executable on the processor, and is used to execute the automatic labeling method of technetium-labeled drugs based on lead shielding as described in claims 1-9, wherein the accommodating component is connected to the control panel through the accommodating connection structure, the accommodating component comprises a rinsing tank accommodating component and a marking tank accommodating component, the syringe barrel comprises a piston connecting rod, a Hall flowmeter, a turntable and an automatic propeller, the retractable structure of lead shielding material and the syringe barrel inside it are connected to the right side of the gear with a slot through a rotating connection mechanism, the control panel and the accommodating component are connected through an iron column fixing mechanism and are connected to the left side of the gear with a slot through a lifting plate, and the processor and the memory are arranged in the control panel.

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