A thermosensitive adaptive bevacizumab co-loaded hydrogel precision syringe

Abstract

The invention relates to the technical field of syringes, and discloses a temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe, comprising a syringe, a piston rod is slidably connected inside the syringe, a needle is installed on the side of the syringe away from the piston rod, a spiral accelerating heat dissipation component is arranged inside the syringe to prevent the external temperature from affecting the physical properties of the hydrogel, the spiral accelerating heat dissipation component comprises an outer cavity for creating a heat dissipation path, the outer cavity is opened inside the syringe, and the hot air is circulated inside the outer cavity by utilizing the principle of natural rise of hot air, and an effective defense line is formed to prevent the change of the physical properties of the hydrogel, specifically, the outer cavity effectively isolates the outer wall of the syringe from the inner cavity, and the hot air is accelerated during the circulation process. The guide block is divided into three types of gases, and these gases are subsequently re-converged to accelerate the flow of the hot air, thereby preventing the hot air from exchanging heat with the inner wall of the syringe, and effectively protecting the hydrogel and bevacizumab therein.

Description

Technical Field

[0001] The invention relates to the technical field of syringes, and in particular to a temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe. Background Art

[0002] The bevacizumab co-loaded hydrogel precision syringe is a medical device handheld by a doctor and is used to inject bevacizumab to treat a variety of cancers, such as metastatic colorectal cancer, non-small cell lung cancer, hepatocellular carcinoma and recurrent glioblastoma.

[0003] However, the existing bevacizumab co-loaded hydrogel precision syringe also exposes some problems: First, the existing bevacizumab co-loaded hydrogel precision syringe requires the doctor to operate it by hand, and the first injection time is relatively long, usually ninety minutes. Considering that the immune system of cancer patients is relatively fragile, the air conditioner is usually not turned on in the ward, but the room temperature is maintained at a relatively comfortable 25 degrees Celsius through ventilation, sunshade and other means. However, the human body temperature and the ideal state of the hydrogel are both around 37 degrees Celsius. This temperature difference will cause the physical properties of the hydrogel to change. Therefore, during the long-term hand-held injection process, the doctor's hand temperature will cause the syringe to heat up, further affecting the physical properties of the hydrogel inside it. More importantly, during the ninety-minute treatment process, the doctor is in close contact with the patient, and the doctor's own body temperature is very likely to be higher than 37 degrees, which will cause the temperature of the syringe and the internal hydrogel to rise to close to or reach 37 degrees Celsius, which will not only change the physical properties of the hydrogel, but also affect the stability of the drug and the accuracy of the injection, and ultimately affect the treatment effect and patient safety.

[0004] Specifically, changes in the physical properties of the hydrogel will cause changes in its key parameters such as viscosity and fluidity, thereby affecting the uniform distribution of the drug and the smoothness of injection. In addition, rising temperatures will also cause degradation or inactivation of the active ingredients of the drug, reducing the therapeutic effect. For patients, this will lead to treatment deviations and prolong treatment time. For doctors, this will not only increase the difficulty and risk of operation, but also cause medical disputes due to poor treatment effects.

[0005] Secondly, during the long injection process, the doctor needs to maintain a high degree of concentration, and due to the close contact between the doctor and the patient, the doctor's hands are prone to sweating and slipping, which not only affects the accuracy of the injection, but also poses a potential threat to the treatment effect and patient safety.

[0006] Specifically, the injection dose of bevacizumab is calculated based on the patient's weight. Usually less than 10 mg is required for every kilogram of body weight. For a 60-kilogram patient, this means that no more than 600 mg of bevacizumab needs to be injected. The injection process often takes up to 90 minutes. During this time, the doctor needs to hold the syringe continuously and maintain a stable injection speed and strength to ensure that the drug can be accurately and evenly injected into the patient's body. However, due to the long injection time, the doctor's hand fatigue and distraction become inevitable problems.

[0007] In addition, close contact between doctors and patients can also cause doctors' hands to sweat, resulting in slippage. This not only affects the doctor's stable control of the syringe, but also increases the risk during the injection process, such as accidental injury to the patient or drug leakage. At the same time, slippage can make it difficult for doctors to accurately judge the progress and effect of the injection, thereby affecting the timely adjustment of the treatment plan.

[0008] To this end, the present invention proposes a temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe. Summary of the invention

[0009] The object of the present invention is to provide a temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe to solve the problems raised in the above background technology.

[0010] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe, comprising a syringe, a piston rod is slidably connected to the inside of the syringe, a needle is installed on the side of the syringe away from the piston rod, a spiral accelerating heat dissipation component is arranged inside the syringe to prevent the external temperature from affecting the physical properties of the hydrogel, the spiral accelerating heat dissipation component comprises an outer cavity for creating a heat dissipation path, the outer cavity is opened inside the syringe, and a plurality of accelerating guide blocks for accelerating the flow of hot air are linearly and equidistantly arranged inside the outer cavity.

[0011] Preferably, the spiral acceleration heat dissipation assembly also includes a plurality of acceleration holes, which are arranged in a circular shape with equal spacing and symmetrically penetrate the outer wall of the syringe, and the acceleration holes extend into the interior of the outer cavity, and the interior of the outer cavity is symmetrically fixed with a guide bevel ring.

[0012] Preferably, a spiral heat sink is fixedly connected to the outer wall of the syringe on one side close to the piston rod, a threaded groove is provided on the outer surface of the spiral heat sink, and the outer surface of the acceleration hole close to the piston rod is fixedly connected to a flow tube, and the end of the flow tube away from the outer cavity passes through the outer surface of the spiral heat sink.

[0013] Preferably, a plurality of rotating rods are linearly and equidistantly arranged inside the outer cavity and are symmetrically rotatably connected, each of the rotating rods is fixedly passed through the outer surface of the acceleration guide block, and the outer surface of each rotating rod is sleeved with a torsion spring, and both ends of the torsion spring are respectively fixedly connected to the outer surface of the acceleration guide block and the inner wall of the outer cavity.

[0014] Preferably, the outer side of the syringe is provided with an adaptive support assembly for preventing the doctor's hands from sweating and slipping, thereby affecting the injection amount of the medicine, the adaptive support assembly includes a plurality of support shells, and the plurality of support shells are arranged in a ring and equidistantly fixedly connected to the outer wall of the syringe, the interior of each of the support shells is fixedly connected to a telescopic rod, the outer surface of the telescopic shaft of each of the telescopic rods is fixedly connected to a support block, each of the support shells is provided with a through hole through the outer surface, each of the through holes is fixedly connected to a shunt tube, and each of the shunt tubes is fixedly connected to the interior of the circulation tube at one end away from the through hole.

[0015] Preferably, the edges of the guiding bevel ring are all inclined, specifically, the edges of the guiding bevel ring are all inclined toward the center side close to the outer cavity.

[0016] Preferably, the plurality of flow tubes are equally divided into three groups, and the length of the flow tubes in each group gradually increases.

[0017] Preferably, the circulation pipes are all inclined, that is, the middle and bottom parts thereof are both inclined.

[0018] Preferably, every two accelerating guide blocks are arranged as a group, the accelerating guide blocks in each group are arranged in a mirror image, and the side of each accelerating guide block close to the needle is inclined toward the middle of every two accelerating guide blocks.

[0019] Preferably, when the telescopic rod is in a fully extended state, there is a gap between the support block and the support shell.

[0020] Preferably, the spiral grooves on the surface of the spiral heat sink divide the spiral heat sink into four convex disk structures, and the flow tubes in three equal groups penetrate the three convex disk structures respectively. Specifically, the flow tubes in three equal groups do not penetrate the convex disk structure farthest from the needle.

[0021] Compared with the prior art, the beneficial effects of the present invention are: 1. By utilizing the principle of natural rise of hot air, the hot air is circulated inside the outer cavity, and an effective defense line is formed to prevent changes in the physical properties of the hydrogel. Specifically, the outer cavity effectively isolates the outer wall of the syringe and the inner cavity. During the circulation process, the hot air is accelerated and the guide block is divided into three types of gases. These gases are subsequently reconverged to accelerate the flow of hot air, thereby preventing the hot air from exchanging heat with the inner wall of the syringe, and effectively protecting the hydrogel and bevacizumab therein. Therefore, the spiral acceleration heat dissipation component ensures the physical properties of the hydrogel and the stability of the drug, so that the drug can be evenly distributed and smoothly injected, thereby improving the treatment effect. At the same time, the spiral acceleration heat dissipation component also reduces the risk and difficulty of the doctor's operation process, avoids medical disputes caused by poor treatment effects, and provides cancer patients with a safer and more effective treatment option.

[0022] Among them: compared with the outer cavity, the cross-sectional area of ​​the acceleration hole is smaller, so when the air enters the outer cavity from the acceleration hole, it will be accelerated based on the Bernoulli principle, which helps to improve the circulation efficiency of hot air, thereby more effectively protecting the hydrogel and bevacizumab from temperature effects.

[0023] Among them: the inclined setting of the guiding bevel ring ensures that when the syringe is subsequently disinfected, the disinfectant will not remain inside the outer cavity, thereby effectively preventing the growth of bacteria and improving the reuse rate and safety of the syringe.

[0024] When the hot air finally passes through the circulation tube, it moves in a spiral motion under the guidance of the spiral heat sink thread groove. This design ensures that the hot air has been fully heated before being discharged, so as not to affect the doctor's operating environment, thereby improving the comfort of the treatment process.

[0025] Among them: the mirror setting of the acceleration guide block and the small adaptive adjustment through the rotating rod and the torsion spring make the hot air more evenly distributed during circulation. In addition, under the action of the acceleration guide block itself accelerating the circulation of hot air, the hot air will generate negative pressure in the outer cavity, attracting external low-temperature air into the outer cavity, thereby effectively preventing the hot air from constantly eroding the interior of the outer cavity.

[0026] 2. By introducing an elastic mechanism, when the doctor holds the syringe, the telescopic rod can be elastically compressed and drive the support block back to the inside of the support shell. When the doctor slips and leaves the syringe, the telescopic rod elastically stretches and drives the support block to contact the doctor's hand, ensuring that the support block always keeps in contact with the doctor's hand. By maintaining stable contact between the syringe and the doctor's hand, the slippage caused by sweating or fatigue of the hand is reduced, allowing the doctor to control the injection speed and strength more accurately. Further, the stable injection process can ensure that the drug is accurately and evenly injected into the patient's body, thereby improving the treatment effect.

[0027] Wherein: the support shell is arranged on the outer wall of the syringe, and the support shell has a large heat dissipation area, which helps to reduce the temperature of the syringe during use.

[0028] Among them: the support shell and the support block are arranged on the side of the syringe close to the piston rod, so that the operator can hold the support block with the tiger's mouth. This design increases the stability of holding the syringe.

[0029] Among them: a shunt pipe penetrating the circulation pipe is arranged inside the support shell, so that when hot air circulates, a part of the hot air will enter the syringe through the shunt pipe and push the support block to adaptively adjust its position, thereby improving the flexibility and use effect of the syringe.

[0030] Among them: the fully extended telescopic rod will create a gap between the support block and the support shell, so that the support shell can always be kept in a breathable state during the disinfection process, avoiding the growth of bacteria and improving the hygiene safety and service life of the syringe. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 It is a front three-dimensional schematic diagram of the main structure of the present invention.

[0032] Figure 2 For the present invention Figure 1 Enlarged three-dimensional schematic diagram of the structure at point A in the middle.

[0033] Figure 3 For the present invention Figure 1 Enlarged three-dimensional schematic diagram of the structure at point B in the middle.

[0034] Figure 4 It is a sectional stereoscopic schematic diagram of the main structure of the present invention.

[0035] Figure 5 For the present invention Figure 4 Enlarged three-dimensional schematic diagram of the structure at point C in the middle.

[0036] Figure 6 For the present invention Figure 4 Enlarged three-dimensional schematic diagram of the structure at point D in the middle.

[0037] Figure 7 For the present invention Figure 4 Enlarged three-dimensional schematic diagram of the structure at E in the middle.

[0038] Figure 8 It is a cross-sectional perspective schematic diagram of the spiral accelerated heat dissipation component of the present invention.

[0039] Fig. 9 For the present invention Figure 8 Enlarged three-dimensional schematic diagram of the structure at F in the middle.

[0040] Fig.10 It is a partially cutaway stereoscopic schematic diagram of the spiral accelerating heat dissipation component of the present invention.

[0041] In the figure: 11, syringe; 12, piston rod; 13, needle.

[0042] 2. Spiral accelerating heat dissipation assembly; 21. External cavity; 22. Accelerating hole; 23. Guide bevel ring; 24. Spiral heat dissipation plate; 25. Flow pipe; 26. Rotating rod; 27. Torsion spring; 28. Accelerating guide block.

[0043] 3. Adaptive support assembly; 31. Support shell; 32. Telescopic rod; 33. Support block; 34. Through hole; 35. Diverter pipe. DETAILED DESCRIPTION

[0044] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] See also Figures 1 to 10 The present invention provides an embodiment: a temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe, comprising a syringe 11, a piston rod 12 is slidably connected inside the syringe 11, a needle 13 is installed on the side of the syringe 11 away from the piston rod 12, and a spiral accelerating heat dissipation component 2 is arranged inside the syringe 11 to prevent the external temperature from affecting the physical properties of the hydrogel. The spiral accelerating heat dissipation component 2 includes an outer cavity 21 for creating a heat dissipation path, the outer cavity 21 is opened inside the syringe 11, and a plurality of accelerating guide blocks 28 for accelerating the flow of hot air are arranged linearly and equidistantly inside the outer cavity 21.

[0046] The spiral accelerating heat dissipation component 2 also includes a plurality of accelerating holes 22, which are arranged in a circular shape at equal intervals and symmetrically penetrate the outer wall of the syringe 11. The accelerating holes 22 extend into the interior of the outer cavity 21, and the interior of the outer cavity 21 is symmetrically fixed with a guiding bevel ring 23.

[0047] A spiral heat sink 24 is fixedly connected to the outer wall of the syringe 11 on one side close to the piston rod 12, and a threaded groove is provided on the outer surface of the spiral heat sink 24. The outer surface of the acceleration hole 22 close to the piston rod 12 is fixedly connected to a flow tube 25, and the end of the flow tube 25 away from the outer cavity 21 passes through the outer surface of the spiral heat sink 24.

[0048] Several rotating rods 26 are arranged linearly and equidistantly inside the outer cavity 21 and are symmetrically rotatably connected. Each rotating rod 26 is fixedly inserted through the outer surface of the acceleration guide block 28. The outer surface of each rotating rod 26 is sleeved with a torsion spring 27, and both ends of the torsion spring 27 are respectively fixedly connected to the outer surface of the acceleration guide block 28 and the inner wall of the outer cavity 21.

[0049] An adaptive support assembly 3 is provided on the outside of the syringe 11 to prevent the doctor's hands from sweating and slipping, thereby affecting the injection amount of the medicine. The adaptive support assembly 3 includes a plurality of support shells 31, which are arranged in a ring-like shape and are fixedly connected to the outer wall of the syringe 11 at equal intervals. A telescopic rod 32 is fixedly connected to the interior of each support shell 31, and a support block 33 is fixedly connected to the outer surface of the telescopic shaft of each telescopic rod 32. A through hole 34 is opened through the outer surface of each support shell 31, and a shunt tube 35 is fixedly connected to the interior of each through hole 34. The end of each shunt tube 35 away from the through hole 34 is fixedly connected to the interior of the circulation tube 25.

[0050] The edges of the guiding oblique ring 23 are all inclined. Specifically, the edges of the guiding oblique ring 23 are all inclined toward the center side close to the outer cavity 21.

[0051] The plurality of flow tubes 25 are equally divided into three groups, and the length of each group of flow tubes 25 gradually increases.

[0052] The circulation pipes 25 are all inclined, that is, the middle and bottom parts thereof are all inclined. Specifically, the side of the circulation pipes 25 away from the spiral heat dissipation plate 24 is inclined toward the side close to the support shell 31 .

[0053] Every two accelerating guide blocks 28 are arranged as a group, and the accelerating guide blocks 28 in each group are arranged in a mirror image, and a side of each accelerating guide block 28 close to the needle 13 is inclined toward the middle of every two accelerating guide blocks 28 .

[0054] When the telescopic rod 32 is in a fully extended state, there is a gap between the support block 33 and the support shell 31 .

[0055] The spiral grooves on the surface of the spiral heat sink 24 divide the spiral heat sink 24 into four convex disc structures. The three equally divided flow tubes 25 penetrate the three convex disc structures respectively. Specifically, the three equally divided flow tubes 25 do not penetrate the convex disc structure farthest from the needle 13 .

[0056] The interior of the syringe 11 is configured as an inner cavity, and the inner cavity stores the bevacizumab co-loaded hydrogel.

[0057] The working principle of the present invention is as follows: The following is an initial state: the telescopic rod 32 is not compressed, the torsion spring 27 is not tightened, and the inner cavity of the syringe 11 is filled with bevacizumab co-loaded hydrogel.

[0058] The following are the specific steps of the work: Among them, the preparation work before injection: Figure 1 As shown, the doctor needs to ensure that the syringe and the injection site of the patient have been disinfected and check whether they are in a sterile environment. The doctor also needs to determine the dosage based on the patient's weight.

[0059] Among them, patients were injected with bevacizumab co-loaded hydrogel: Figure 1 and Figure 7 As shown, the doctor holds the syringe 11 in his hand, and the doctor's base of thumb pushes the support block 33 against the inside of the support shell 31. At this time, the telescopic rod 32 is elastically compressed, and the doctor randomly aligns the needle 13 with the part of the patient to be injected and inserts the needle 13 into the patient's body.

[0060] Next, the doctor begins to slowly push the piston rod 12 to push the bevacizumab co-loaded hydrogel out of the syringe 11. As the bevacizumab co-loaded hydrogel flows into the patient's body, the thermosensitive hydrogel begins to form a gel structure due to the effect of body temperature, thereby slowing down the release rate of the drug, that is, the bevacizumab is slowly and continuously released.

[0061] At the same time, during the injection process, the doctor needs to continue to observe the patient's reaction to ensure that the injection goes smoothly.

[0062] Among them, preventing the temperature of the syringe 11 from increasing and affecting the physical properties of the hydrogel: Figures 1 to 6 as well as Figures 8 to 10 As shown, as the doctor holds the syringe 11 for a long time to inject the bevacizumab co-loaded hydrogel and is in close contact with the patient, the temperature of the doctor's hands rises, causing the temperature of the syringe 11 to also rise.

[0063] At this time, the outer cavity 21 serves as a heat dissipation passage, and the air inside it is heated. Based on the principle that hot air rises naturally, the hot air flows in the outer cavity 21 toward the side close to the piston rod 12. During the circulation process, the hot air is blocked by the acceleration guide block 28. Since the acceleration guide block 28 is set in a mirror image, the acceleration guide block 28 divides the airflow into three streams, namely the airflow located in the middle of the two acceleration guide blocks 28 and the airflow crossing the surfaces of the acceleration guide blocks 28 on both sides. As the airflow passes, the airflows on both sides mix with the middle airflow at the upper end of the acceleration guide block 28 and produce impacts in the same direction, thereby producing an acceleration effect. The accelerated flow of hot air reduces the heat exchange time between the hot air and the outer cavity 21 and the inner wall of the syringe 11, effectively preventing the hot air from continuously affecting the internal bevacizumab co-loaded hydrogel.

[0064] At the same time, the hot air continuously flows to the circulation pipe 25, and moves based on its own upward trend and the guidance of the spiral groove on the surface of the spiral heat sink 24. The spiral groove design on the surface of the spiral heat sink 24 not only increases the heat dissipation area, but also the circulation pipe 25 is equally divided into three groups and penetrates the convex disc structure of different heights. This design not only prevents the hot air from mixing with each other on the outer surface of the spiral heat sink 24, but also enables each group of circulation pipes 25 to fully utilize the space of the spiral heat sink 24 for heat dissipation. By each group of circulation pipes 25 penetrating the spiral heat sink 24, it is ensured that the hot air can fully exchange heat with the spiral heat sink 24 during the flow process, thereby effectively dissipating its heat into the air, preventing the hot air from mixing with each other, and making more full use of the space of the spiral heat sink 24, thereby improving the heat dissipation efficiency.

[0065] In addition, when hot air escapes from the outer cavity 21, negative pressure is formed inside the outer cavity 21. Based on the Bernoulli principle, that is, the fluid has a low pressure where the flow rate is high and a high pressure where the flow rate is low, the external air is accelerated and sucked into the outer cavity 21 to fill the gap. In this process, the acceleration hole 22 serves as a channel connecting the outside and the outer cavity 21, and its cross-sectional area is smaller than that of the outer cavity 21, which further accelerates the speed of external air intake. Therefore, the acceleration hole 22 and the outer cavity 21 not only effectively prevent hot air from continuously eroding the inside of the outer cavity 21, but also ensure that the bevacizumab co-loaded hydrogel inside is always kept in a suitable temperature environment.

[0066] Among them, to prevent doctors’ hands from sweating and slipping, thereby affecting the injection amount of bevacizumab co-loaded hydrogel: Figure 4 , Figure 6 as well as Figure 7As shown, when the doctor holds the syringe for a long time to inject bevacizumab co-loaded hydrogel into the patient, the doctor's body temperature will rise due to the close distance between the doctor and the patient. At the same time, since the injection dose needs to be precisely controlled, the doctor's hands are prone to sweating while concentrating on the operation, causing the syringe to slip and affecting the injection effect.

[0067] When the doctor's hands sweat and slip, the above steps have shown that the support block 33 is pressed against the inside of the support shell 31, and the telescopic rod 32 elastically contracts. When the doctor's hands sweat and slip, the telescopic rod 32 will immediately drive the support block 33 to extend, so that the support block 33 is always in contact with the doctor's base of the thumb, thereby providing a stable grip to prevent slipping.

[0068] In addition, since the hot air inside the outer cavity 21 will continuously flow to the outside through the circulation tube 25, and part of the circulation tube 25 is interconnected with the shunt tube 35, part of the hot air will enter the support shell 31 through the shunt tube 35 and the through hole 34. As the amount of air inside the support shell 31 increases, the air is compressed. Although the support shell 31 is not completely in a closed state, during the long injection process, the circulation tube 25 continuously inputs air, and the air inside the support shell 31 must flow back through the shunt tube 35 to be discharged, which causes the two types of air to collide.

[0069] Based on the principles of gas dynamics, the air inside the support shell 31 will maintain a relatively high mass. As the amount of air inside increases, the air inside the support shell 31 will push the support block 33 and drive the telescopic rod 32 to further extend, so that the support block 33 obtains additional power in addition to the elastic force of the telescopic rod 32. This not only enhances the contact force between the support block 33 and the doctor's thumb and index finger, but also improves the stability and controllability of the syringe.

[0070] In addition, since the support shell 31 has a large heat dissipation area, the heat will be dissipated quickly, and the doctor holds the support block 33 with the tiger's mouth and the outer wall of the syringe 11 with the fingers. Therefore, some areas of the syringe 11 are not as hot as the areas that are in direct contact with the doctor's hands. The contact area is more likely to make the doctor sweat due to the higher temperature.

[0071] As a result, the quality of hot air output by each circulation tube 25 is different, resulting in different air push on each support block 33. This design enables the support block 33 to adaptively adjust its own position to suit the doctor's operating habits, thereby further improving the accuracy and comfort of injection.

[0072] Among them, the used syringes are disinfected: after the doctor injects the bevacizumab co-loaded hydrogel, the syringe needs to be disinfected. According to regulations, the doctor should discard or destroy the needle13 to avoid the risk of cross infection.

[0073] ‌The doctor can then place the syringe in a container filled with alcohol and soak it for a period of time to ensure thorough disinfection. The syringe then needs to be air-dried to avoid alcohol residue affecting the next use.

[0074] Among them, since the guide bevel ring 23 is inclined, the alcohol inside the outer cavity 21 will flow out under the guidance of the guide bevel ring 23, and at the same time, this part of the alcohol will flow to the outside through the inclined circulation tube 25, which helps to accelerate the drying process of the syringe. In addition, when not in use, there is a gap between the support block 33 and the support shell 31, so that air can circulate between them. Therefore, the inside of the support shell 31 will not breed bacteria due to its closedness. Therefore, the design of the guide bevel ring 23 and the support block 33 is not only convenient for the disinfection and drying of the syringe, but also conducive to its reuse, thereby improving the utilization efficiency of medical resources.

[0075] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or equipment that includes a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or equipment. In the absence of further restrictions, the elements defined by the sentence "comprise one..." does not exclude the presence of other identical elements in the process, method, article or equipment that includes the elements.

[0076] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe, comprising a syringe (11), a piston rod (12) being slidably connected inside the syringe (11), and a needle (13) being installed on a side of the syringe (11) away from the piston rod (12), characterized in that: The syringe (11) is provided with a spiral accelerating heat dissipation component (2) for preventing the external temperature from affecting the physical properties of the hydrogel. The spiral accelerating heat dissipation component (2) comprises an outer cavity (21) for creating a heat dissipation path. The outer cavity (21) is opened inside the syringe (11). The outer cavity (21) is provided with a plurality of accelerating guide blocks (28) for accelerating the flow of hot air in a linearly equidistant arrangement. The spiral accelerating heat dissipation component (2) also comprises a plurality of accelerating holes (22). The accelerating holes (22) are all arranged in an annular manner and equidistantly and symmetrically penetrate the outer wall of the syringe (11). The accelerating holes (22) extend into the outer cavity (21). The inner part of the outer cavity (21) is symmetrically fixedly connected with a guiding oblique ring (23). The outer wall of the syringe (11) on one side close to the piston rod (12) is fixedly connected with a spiral heat dissipation plate (24). The outer surface of the spiral heat dissipation plate (24) is provided with a spiral heat dissipation plate (24). The outer surface of the acceleration hole (22) near the piston rod (12) is fixedly connected with a flow tube (25), and the end of the flow tube (25) away from the outer cavity (21) passes through the outer surface of the spiral heat dissipation plate (24). The inner part of the outer cavity (21) is linearly equidistantly arranged and symmetrically rotatably connected with a plurality of rotating rods (26), each of which is fixedly passed through the outer surface of the acceleration guide block (28), and the outer surface of each rotating rod (26) is sleeved with a torsion spring (27), and the two ends of the torsion spring (27) are respectively fixedly connected to the outer surface of the acceleration guide block (28) and the inner wall of the outer cavity (21), and every two acceleration guide blocks (28) are arranged as a group, and the acceleration guide blocks (28) in each group are mirror-imaged, and the side of each acceleration guide block (28) close to the needle head (13) is inclined toward the middle of every two acceleration guide blocks (28).

2. A temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe according to claim 1, characterized in that: The outer side of the syringe (11) is provided with an adaptive support assembly (3) for preventing the doctor's hands from sweating and slipping, thereby affecting the injection amount of the medicine. The adaptive support assembly (3) comprises a plurality of support shells (31). The plurality of support shells (31) are arranged in a ring-like shape and fixedly connected to the outer wall of the syringe (11) at equal intervals. The interior of each support shell (31) is fixedly connected to a telescopic rod (32). The outer surface of the telescopic shaft of each telescopic rod (32) is fixedly connected to a support block (33). Each support shell (31) is provided with a through hole (34) through the outer surface. The interior of each through hole (34) is fixedly connected to a shunt tube (35). The end of each shunt tube (35) away from the through hole (34) is fixedly connected to the interior of the circulation tube (25).

3. A temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe according to claim 1, characterized in that: The edges of the guiding oblique ring (23) are all arranged to be inclined, and specifically, the edges of the guiding oblique ring (23) are all inclined towards the central side close to the outer cavity (21).

4. A temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe according to claim 1, characterized in that: The plurality of flow tubes (25) are equally divided into three groups, and the length of the flow tubes (25) in each group gradually increases.

5. A temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe according to claim 4, characterized in that: The circulation pipes (25) are all arranged at an inclination, that is, the middle and bottom parts thereof are both arranged at an inclination.

6. A temperature-sensitive adaptive bevacizumab co-loaded hydrogel precision syringe according to claim 2, characterized in that: When the support block (33) and the telescopic rod (32) are in a fully extended state, there is a gap between the support block (33) and the support shell (31).

Images