Composition with anti-wrinkle and dark circle improving effects, preparation method and application thereof

Abstract

The present invention belongs to the field of cosmetics technology and discloses a composition with anti-wrinkle and dark circle-improving effects, as well as its preparation method and application. The composition comprises an Arabidopsis thaliana extract, an Zingiber officinale extract, hydrolyzed ginsenosides, and acetylated sodium hyaluronate. The composition provided by the present invention, through the synergistic combination of the Arabidopsis thaliana extract, the Zingiber officinale extract, the acetylated sodium hyaluronate, and the hydrolyzed ginsenosides, is gentle and non-irritating to the skin when applied to the eyes, effectively reducing the area and depth of wrinkles, lightening wrinkles, and improving dark circles.

Description

Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and particularly relates to a composition with the effects of anti-wrinkle and improving dark circles, and a preparation method and application thereof. Background Art

[0002] The skin around the eyes is thin and less moisturized, with almost no sebum and sweat glands, lacking moisture and oil. The capillaries in the skin around the eyes are extremely fine, the fat content is low, and there is little collagen and elastic fiber. Lacking muscle support, the skin around the eyes is more prone to sagging, resulting in wrinkles and dark circles. The skin around the eyes is frequently used, with many blinks per day due to normal work, and frequent facial expressions, which can easily lead to dynamic fine lines. The upper eyelid, lower eyelid, and outer canthus tissue around the eyes are the first areas to show signs of aging. Under the constant influence of the internal and external environment, the cell structure and function of the skin tissue degenerate, resulting in physiological phenomena such as changes in skin texture (elasticity, tension, thickness, texture), pigment changes (pigmentation), and vascular atrophy or proliferation (dullness, uneven skin tone, redness), manifesting as various signs of aging: structural, pigmentary, and vascular dark circles.

[0003] Currently, consumer demand for anti-aging eye care and dark circle reduction has increased significantly, leading to a growing number of studies on anti-wrinkle, eye area firming, and dark circle improvement products. However, most eye care products suffer from limited efficacy, unclear mechanisms of action, long onset of action, or high irritation. Therefore, developing a product that offers multiple benefits—anti-wrinkle, fine line reduction, and dark circle reduction—while also being gentle and non-irritating is highly desirable. Summary of the Invention

[0004] The present invention aims to address at least one of the technical problems existing in the aforementioned prior art. To this end, the present invention provides a composition with anti-wrinkle and dark circle-improving properties, as well as a preparation method and application thereof. The composition is gentle and non-irritating to the skin around the eyes, exhibiting multiple benefits, including anti-wrinkle effects, reducing wrinkle depth and area, fading fine lines, firming the skin around the eyes, and fading dark circles.

[0005] A first aspect of the present invention provides a composition comprising an Arabidopsis thaliana extract, an Zingiber officinale extract, hydrolyzed ginsenosides, and acetylated sodium hyaluronate.

[0006] Specifically, the effects of the components in the composition of the present invention are as follows:

[0007] Arabidopsis extracts contain Arabidopsis polyphenols, vitamin C, vitamin E, and beta-carotene, all naturally found in an optimal ratio, which can protect telomeres from oxidative stress. AT-65, a protein found in Arabidopsis extracts, activates telomerase reverse transcriptase, a key component of telomerase, thereby significantly increasing telomere activity and preventing accelerated telomere shortening. Mitochondria isolated from Arabidopsis are rich in five complete mitochondrial complexes, including NADH dehydrogenase, succinate dehydrogenase, cytochrome C reductase, cytochrome C oxidase, and ATP synthase. These complexes can induce the expression of components of mitochondrial complex IV, increasing the number of mitochondria and thereby improving cellular respiration efficiency and energy supply. If cells are locally hypoxic, they undergo non-mitochondrial respiration, which is far less efficient than mitochondrial respiration and produces harmful substances. Furthermore, a new class of signal peptides has been discovered around Arabidopsis polysomes, which can guide protein synthesis and localization, better allocate cellular resources, improve oxygen utilization efficiency, and increase the proportion of mitochondrial respiration. Arabidopsis extract contains a large number of rare active ingredients, which play a role in protecting telomeres, improving cell metabolism and enhancing effective cell respiration, ultimately reducing the number of senescent cells, promoting the expression of collagen and elastin, and enriching the extracellular matrix.

[0008] Red ginger extract is rich in terpenoids (primarily sesquiterpenoids) and polyphenols, long used in traditional medicine to treat pain, inflammation, indigestion, and toxic injuries. Sesquiterpenoids such as zingerone contained in red ginger extract can regulate melanin formation pathways (Akt, ERK1 / 2, MITF, TRP1), inhibit excessive melanin production, reduce oxidative stress (ROS, HO-1), and prevent blood leakage (NO), thereby alleviating inflammatory stress (NF-kB, PEG2) and enhancing capillary integrity (collagen, elastin). This manifests itself in the eye area, with reduced melanin deposition, lessened pigmented dark circles, and brightened under-eye areas. Increased oxygenation in the eye skin improves capillary blood flow, reducing vascular dark circles, alleviating puffiness, and shrinking eye bags.

[0009] Hydrolyzed ginsenosides can endogenously activate the antioxidant signaling pathway Nfr2, inhibiting reactive oxygen species (ROS) produced by mitochondrial imbalance, boosting the expression of endogenous antioxidants HO-1 and NQQ-1, and maintaining mitochondrial function. They also combat inflammation at the root, inhibiting the classic inflammatory signaling pathway NF-kB and reducing the release of the inflammatory factor IL-6 and the aging factor p65. They also inhibit the collagen degradation pathway MAPK, suppressing the production of MMP-1 and reducing collagen breakdown. Furthermore, they activate the collagen regeneration pathway TGF-β1, promoting collagen regeneration. These ingredients offer anti-wrinkle and skin-firming benefits through four key strategies: anti-oxidation, anti-inflammation, anti-degradation, and promoting anabolic activity.

[0010] Acetylated sodium hyaluronate, due to the modification of the acetylated group, has enhanced skin penetration, reaching the dermis. Compared to non-acetylated hyaluronic acid, acetylated sodium hyaluronate is more resistant to hyaluronidase, providing moisturizing, plumping, and supporting effects on the skin. It activates the skin's defense mechanisms, enhancing the activity of thioredoxin reductase and inhibiting the production of reactive oxygen species (ROS). It also activates the skin's anti-pollution mechanisms and increases the production of p62 protein, thereby protecting the extracellular matrix and protecting it from light pollution. Furthermore, acetylated sodium hyaluronate inhibits MMP-1, MMP-3, and MMP-9, protecting collagen from degradation and combating photoaging.

[0011] In the composition of the present invention, Arabidopsis thaliana extract enhances mitochondrial activity and effective respiration, enhances signal transduction, enhances cell metabolism and vitality, accelerates protein and collagen synthesis, resists aging and firming, enhances contours, and resists gravitational aging; Red ball ginger extract starts from the source of melanin deposition and the inflammation-inducing pathway to improve the pigmentation of the eye; hydrolyzed ginsenosides endogenously stimulate the antioxidant signaling pathway Nfr2 in the body, resist photoaging, reduce collagen decomposition, and promote collagen synthesis; acetylated sodium hyaluronate enriches the intercellular matrix, making the skin more elastic and resilient, and promoting collagen and elastin to interweave into a network, filling between the cell matrix, making the skin firm and smooth. Based on the mutual cooperation and synergistic enhancement between the above four ingredients, the composition of the present invention can clearly target, accurately and effectively fight wrinkles and improve dark circles, and tighten the contours around the eyes.

[0012] In some embodiments of the present invention, the composition includes, by weight, 0.02-0.4 parts of Arabidopsis thaliana extract, 0.005-0.015 parts of Zingiber officinale extract, 0.001-0.18 parts of hydrolyzed ginsenosides, and 0.01-0.2 parts of acetylated sodium hyaluronate.

[0013] In some embodiments of the present invention, the weight ratio of the Arabidopsis thaliana extract to the Zingiber officinale extract is 10 to 30:1; for example, it can be any point value among 10:1, 12:1, 14:1, 16:1, 18:1, 20:1, 22:1, 24:1, 26:1, 28:1, 30:1, or a range value between any two point values.

[0014] In some embodiments of the present invention, the weight ratio of the acetylated sodium hyaluronate to the hydrolyzed ginsenosides is 2 to 10:1; for example, it can be any point value among 2:1, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, or a range value between any two point values.

[0015] The second aspect of the present invention provides a method for preparing the composition according to the first aspect of the present invention, comprising the following steps:

[0016] The Arabidopsis thaliana extract, the Zingiber officinale extract, the hydrolyzed ginsenosides and the acetylated sodium hyaluronate are mixed to obtain a composition.

[0017] The third aspect of the present invention provides use of the composition described in the first aspect of the present invention in preparing cosmetics.

[0018] The fourth aspect of the present invention provides a cosmetic comprising the composition according to the first aspect of the present invention.

[0019] In some embodiments of the present invention, the content of the composition in the cosmetic is 0.001 to 10 wt %, preferably 0.01 to 5 wt %, and more preferably 0.01 to 2 wt %.

[0020] In some embodiments of the present invention, the cosmetic further comprises a cosmetic base excipient, wherein the cosmetic base excipient comprises at least one of a thickener, a moisturizer, an emollient, a pH regulator, a preservative, and a fragrance.

[0021] In some embodiments of the present invention, the thickener includes at least one of carbomer, hydroxyethyl cellulose, xanthan gum, acrylates / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / beheneth-25 methacrylate crosspolymer, sodium acrylate copolymer, CAESALPINIA SPINOSA gum, and ammonium polyacryloyldimethyl taurate.

[0022] In some embodiments of the present invention, the moisturizing agent includes at least one of glycerin, propylene glycol, butylene glycol, ethoxydiglycol, 1,2-hexanediol, dipropylene glycol, 1,2-pentanediol, 1,3-propylene glycol, and isoprene glycol.

[0023] In some embodiments of the present invention, the emollient includes at least one of shea butter, dimethicone, squalane, isononyl isononanoate, polyglyceryl-3 methylglucose distearate, and cetearyl glucoside.

[0024] In some embodiments of the present invention, the pH adjuster includes at least one of aminomethyl propanol, arginine, tromethamine, potassium hydroxide, and sodium hydroxide.

[0025] In some embodiments of the present invention, the preservative includes at least one of phenoxyethanol, methylparaben, propylparaben, and chlorphenesin.

[0026] In some embodiments of the present invention, the cosmetics are eye cosmetics, and the eye cosmetics include essence, emulsion, eye gel, eye mask, eye shadow, gel or eye cream.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] (1) The composition provided by the present invention is a composition that, through the mutual combination and synergistic enhancement of Arabidopsis thaliana extract, ginger extract, acetylated sodium hyaluronate and hydrolyzed ginsenosides, has a clear target, precise and effective anti-wrinkle effect, improves dark circles and tightens the eye contour. Among them, Arabidopsis thaliana extract enhances mitochondrial activity and effective respiration, enhances signal transduction, enhances cell metabolism and vitality, accelerates protein and collagen synthesis, resists aging and tightens, improves contours, and resists gravity aging; ginger extract improves the pigmentation of the eye skin from the source of melanin deposition and the inflammatory induction pathway; hydrolyzed ginsenosides endogenously stimulate the antioxidant signal pathway Nfr2 in the body, resists photoaging, reduces collagen decomposition, and promotes collagen synthesis; acetylated sodium hyaluronate enriches the intercellular matrix, makes the skin more elastic and tough, and promotes collagen and elastin to interweave into a network, filling between the cell matrix, making the skin firm and smooth.

[0029] The aforementioned Arabidopsis extract, Zingiber officinale extract, sodium acetylated hyaluronate, and hydrolyzed ginsenosides exhibit a mutually reinforcing and synergistic relationship. Activated mitochondrial activity promotes intercellular signaling, enhancing the inhibitory effect of Zingiber officinale extract on the melanogenesis pathway and preventing excessive melanin production. Arabidopsis extract improves effective respiration, reducing ROS production, further reducing oxidative stress and inflammation. Combined with Zingiber officinale extract, it reduces pro-inflammatory symptoms and pigmentation, protecting vascular and capillary integrity. Zingiber officinale extract combats oxidative stress, while hydrolyzed ginsenosides scavenge free radicals through the Nrf2 pathway, inhibiting inflammatory pathways. The inhibition of collagenase by hydrolyzed ginsenosides and the stimulation of collagen production by Arabidopsis extract contribute to anti-wrinkle and firming effects. Hydrolyzed ginsenosides and sodium acetylated hyaluronate share similar pathways in combating photoaging, resulting in a mutually reinforcing effect. Sodium acetylated hyaluronate and Arabidopsis extract also synergize in enhancing the extracellular matrix, contributing to a firming and elastic effect. In short, aging is an inevitable temporal state caused by the combined effects of oxidative damage, decreased cell replication ability (mitochondrial functional degradation), and extracellular matrix degradation (decreased collagen and elastin content). The composition of the present invention can synergistically enhance the effects of the above pathways to maximize the improvement of the skin condition around the eyes.

[0030] (2) The composition provided by the present invention is applied to the eyes, is mild and non-irritating to the skin, can effectively reduce the area and depth of wrinkles, lighten wrinkles, and improve dark circles. DETAILED DESCRIPTION

[0031] In order to make the technical solution of the present invention more clearly understood by those skilled in the art, the following examples are given for illustration. It should be noted that the following examples do not limit the scope of protection claimed by the present invention.

[0032] Unless otherwise specified, the raw materials, reagents or devices used in the present invention can be obtained from conventional commercial channels or by existing known methods.

[0033] Example 1

[0034] A composition and eye essence with the effects of anti-wrinkle and improving dark circles.

[0035] A composition for anti-wrinkle and dark circle improvement comprises Arabidopsis thaliana extract, Zingiber officinale extract, hydrolyzed ginsenosides and acetylated sodium hyaluronate.

[0036] An eye essence comprises the above composition, deionized water, carbomer, butylene glycol, methylparaben, phenoxyethanol, aminomethyl propanol and essence.

[0037] Examples 1-3, Comparative Examples 1-5 and the blank example all provide an eye essence, the difference being that the contents of the raw material components are different, as shown in Table 1; the units in Table 1 are weight percentage (%).

[0038] Table 1 Eye Essence Formula

[0039]

[0040]

[0041] It is understood that “ / ” in Table 1 means not contained.

[0042] The preparation method of the eye essence of Examples 1-3, Comparative Examples 1-5 and the blank example comprises the following steps:

[0043] (1) Weigh the raw materials according to the weight percentage in Table 1, add the raw materials of phase A into the emulsifying pot, stir and heat to 80°C, keep stirring for 10 minutes and then cool down;

[0044] (2) Cool to 60°C, add Phase B raw materials, stir for 5 minutes until uniform, and continue to cool;

[0045] (3) Cool to 45°C, add Phase C ingredients, and stir for 10 minutes until uniform to obtain the eye essence.

[0046] Examples 4-11 all provide an eye essence, and the preparation method is the same as that of Example 1, except that the contents of the raw material components are different, as shown in Table 2; the units in Table 2 are weight percentage (%).

[0047] Table 2 Eye Essence Formula

[0048]

[0049] Product effect testing

[0050] 1. Anti-wrinkle test

[0051] 1. Using the eye serums prepared in Examples 1-3, Comparative Examples 1-5, and a blank as test samples, 45 volunteers were screened and divided into nine groups, each consisting of five subjects aged 30-50 years. The eye wrinkles were used as the test area, and subjects with the same wrinkle grade were randomly assigned to one side of the eye, leaving the other side unapplied. The test samples were applied to the applied areas for 28 consecutive days. PIMIA software was used to analyze and assess the percentage reduction in wrinkle depth and wrinkle area over time. The test results are shown in Tables 3 and 4.

[0052] Table 3 Wrinkle depth reduction percentage

[0053]

[0054] Table 4 Wrinkle area reduction percentage

[0055]

[0056]

[0057] As can be seen from the results in Tables 3 and 4, when compared with the blank examples, Examples 1-3 of the present invention were significantly superior to the blank examples in reducing wrinkle depth and wrinkle area after 28 days of use, indicating that the composition of the present invention has an anti-wrinkle effect.

[0058] Comparative Examples 1-4 remove the Arabidopsis thaliana extract, red ball ginger extract, acetylated sodium hyaluronate, and hydrolyzed ginsenosides in the composition respectively, and the amount missing is supplemented by the remaining efficacy components, and the matrix excipients of Comparative Examples 1-4 are consistent with the embodiment. Example 1 is tested for 28 days of use, and is significantly better than Comparative Examples 1-4 in reducing wrinkle depth and reducing wrinkle area. This shows that after selecting the four component combinations of Arabidopsis thaliana extract, red ball ginger extract, acetylated sodium hyaluronate, and hydrolyzed ginsenosides, there is a good improvement effect in responding to cell energy attenuation, effective respiration weakening, endogenous antioxidant and anti-inflammatory, promoting extracellular matrix collagen and elastin synthesis, and resisting the collagen decomposition caused by skin photoaging. It can be seen that the four components in the composition of the present invention complement each other, have obvious synergistic effects, and can more comprehensively play the anti-wrinkle effect.

[0059] Comparing Example 1 with Comparative Example 5, Example 5 omitted the Arabidopsis extract and hydrolyzed ginsenosides, with the remaining active ingredients providing the missing components. Example 1 significantly outperformed Comparative Example 5 in reducing wrinkle depth and area. This is because Comparative Example 5 lacks active ingredients that counteract cellular energy recovery and inhibit collagen breakdown. The red ginger extract and acetylated sodium hyaluronate alone have limited wrinkle-improving effects. This demonstrates that the composition of the present invention significantly outperforms any combination of two or three of these components in terms of anti-wrinkle effectiveness.

[0060] 2. Using the eye serums prepared in Examples 6-7 and 10-11 as test samples, 20 subjects aged 30-50 years were selected. The eye wrinkles were used as the test area, and subjects with similar wrinkle levels were randomly assigned to one side of the eye where the test sample was applied, while the other side remained unapplied. The test samples were applied to the applied areas for 28 consecutive days. PIMIA software was used to analyze and assess the percentage reduction in wrinkle depth and wrinkle area over time. The test results are shown in Tables 5 and 6.

[0061] Table 5 Wrinkle depth reduction percentage

[0062]

[0063]

[0064] Table 6 Wrinkle area reduction percentage

[0065]

[0066] The results in Tables 5 and 6 show that the difference between Example 6 and Example 10 lies in the ratio of sodium acetylated hyaluronate to hydrolyzed ginsenosides in Example 6 (2:1), while the ratio of sodium acetylated hyaluronate to hydrolyzed human saponins in Example 10 (1:1). The difference between Example 7 and Example 11 lies in the ratio of sodium acetylated hyaluronate to hydrolyzed ginsenosides in Example 7 (10:1), while the ratio of sodium acetylated hyaluronate to hydrolyzed human saponins in Example 11 (20:1). In terms of the percentage reduction in wrinkle depth and wrinkle area, Examples 6-7 outperformed Examples 10-11 in both wrinkle depth and wrinkle area reduction. This demonstrates that the anti-wrinkle effect can be further enhanced when the addition of sodium acetylated hyaluronate and hydrolyzed ginsenosides meets a certain ratio.

[0067] In summary, the composition obtained through scientific formulation of the present invention has obvious synergistic effect in anti-wrinkle efficacy.

[0068] 2. Eye skin color test

[0069] According to the eye skin color value L * The size of the eye determines the depth of the skin color around the eyes. * The larger the value, the lighter the skin around the eyes is and the better the effect of improving dark circles.

[0070] 1. Using the eye serums prepared in Examples 1-3, Comparative Examples 1-5, and a blank as test samples, 54 female volunteers aged 30-55 with noticeable dark circles were recruited and divided into nine groups of six. Each group received the corresponding eye serum. Apply the serum to the eye area and massage in for absorption every morning and evening for 28 consecutive days.

[0071] On the 0th, 14th and 28th day after using the eye essence, the same position of the lower eyelid was used as the test area in a constant temperature and humidity environment. VISIA-CR photos were taken with a facial imaging camera to record the skin color difference value. * 14 -L * 0 is the color difference between the 14th day and the 0th day, L * 28 -L * 0 is the color difference between day 28 and day 0. The test results are shown in Table 7.

[0072] Table 7 Skin color difference

[0073]

[0074] From the results in Table 7, it can be seen that, compared with the blank example, Examples 1-3 of the present invention are significantly better than the blank example in improving skin color value after 28 days of use test, indicating that the composition of the present invention has the effect of improving dark circles.

[0075] Compared with Example 1, Comparative Examples 1-4 respectively eliminated Arabidopsis extract, Red Ginger extract, acetylated sodium hyaluronate, and hydrolyzed ginsenosides in the composition, and Comparative Example 5 eliminated Arabidopsis extract and hydrolyzed ginsenosides. The amount of the effective components eliminated in Comparative Examples 1-5 was supplemented by the remaining effective components. After 28 days of use test, Example 1 was significantly better than Comparative Examples 1-5 in terms of skin color improvement effect, and the effect of Comparative Example 2 lacking Red Ginger extract was the worst. This is because the deposition and metabolism of melanin involve the respiratory efficiency of cells, the inflammatory stress caused by oxidative stress, and the inflammatory signal transduction induced by skin photoaging. They are a whole and affect the overall activity of melanin. It can be seen that the four components in the composition of the present invention complement each other and have obvious synergistic effects, which can better improve dark circles, and the improvement effect on dark circles is significantly better than any two or three component combinations.

[0076] 2. Using the eye serums prepared in Examples 4-5 and 8-9 as test samples, 24 female volunteers aged 30-55 with noticeable dark circles were selected and divided into four groups of six. Each group received the corresponding eye serum. Apply to the eye area and massage in for absorption every morning and evening for 28 consecutive days.

[0077] On the 0th, 14th and 28th day after using the eye essence, the same position of the lower eyelid was used as the test area in a constant temperature and humidity environment. VISIA-CR photos were taken with a facial imaging camera to record the skin color difference value. * 14 -L * 0 is the color difference between the 14th day and the 0th day, L * 28 -L * 0 is the color difference between day 28 and day 0. The test results are shown in Table 8.

[0078] Table 8 Skin color difference

[0079]

[0080] The results in Table 8 show that the difference between Example 4 and Example 8 lies in the ratio of Arabidopsis thaliana extract to Zingiber officinale extract in Example 4 (10:1), while the ratio of Arabidopsis thaliana extract to Zingiber officinale extract in Example 8 (8:1). The difference between Example 5 and Example 9 lies in the ratio of Arabidopsis thaliana extract to Zingiber officinale extract in Example 5 (30:1), while the ratio of Arabidopsis thaliana extract to Zingiber officinale extract in Example 9 (40:1). Based on the skin color difference test results, Examples 4-5 are superior to Examples 8-9 in terms of dark circle improvement. This demonstrates that the addition of Arabidopsis thaliana extract and Zingiber officinale extract in a certain ratio can further enhance the dark circle improvement effect.

[0081] In summary, based on the above embodiments and comparative example data, the present invention adopts a composition composed of Arabidopsis thaliana extract, Zingiber officinale extract, hydrolyzed ginsenosides and acetylated sodium hyaluronate, which has anti-wrinkle and dark circle improvement effects, comprehensive targets, precise and effective, and has obvious synergistic effects, rather than a simple superposition of effects, and can achieve the effect of "1+1>2"; in addition, when the added amounts of Arabidopsis thaliana extract and Zingiber officinale extract, and / or the added amounts of acetylated sodium hyaluronate and hydrolyzed ginsenosides meet a certain ratio, it can further obtain better anti-wrinkle and dark circle improvement effects.

[0082] Example 12

[0083] A composition and eye cream with the effects of anti-wrinkle and improving dark circles.

[0084] A composition for anti-wrinkle and dark circle improvement comprises Arabidopsis thaliana extract, Zingiber officinale extract, hydrolyzed ginsenosides and acetylated sodium hyaluronate.

[0085] An eye cream comprises the above composition, deionized water, carbomer, butylene glycol, methylparaben, phenoxyethanol, shea butter, polydimethylsiloxane, squalane, isononyl isononanoate, polyglyceryl-3 methylglucose distearate, cetearyl glucoside, aminomethyl propanol and essence.

[0086] Example 12 and Comparative Examples 6-9 all provide an eye cream, the difference being that the types of raw material components are different, as shown in Table 9; the units in Table 9 are weight percentage (%).

[0087] Table 9

[0088]

[0089]

[0090] It is understood that “ / ” in Table 9 means not contained.

[0091] The preparation method of the eye cream of Example 12 and Comparative Examples 6-9 comprises the following steps:

[0092] (1) Weigh the raw materials according to the weight percentage in Table 1, add the raw materials of phase A to the emulsifying pot, stir and heat to 80°C, and keep stirring for 10 minutes; add the raw materials of phase B to the oil phase pot, stir and heat to 80°C, and keep stirring for 10 minutes; transfer the raw materials of the oil phase to the emulsifying pot and homogenize and emulsify until uniform;

[0093] (2) Cool to 60°C, add Phase C, stir for 5 minutes until uniform, and continue cooling;

[0094] (3) Cool to 45°C, add the ingredients of phase D, and stir for 10 minutes until uniform to obtain the eye cream.

[0095] Patch test

[0096] According to the test method of the "Technical Specification for Safety of Cosmetics", the eye creams prepared in Example 12 and Comparative Examples 6-9 were subjected to human patch tests. Table 10 shows the skin reaction grading standard of the patch test. The test results are shown in Table 11.

[0097] Table 10 Skin patch test skin reaction grading standard

[0098]

[0099] Table 11 Patch test results

[0100]

[0101] From the results in Table 11, it can be seen that compared with retinol palmitate, collagen, European aescin, and sodium mannose phosphate, the composition of Arabidopsis thaliana extract, Zingiber officinale extract, hydrolyzed ginsenosides, and acetylated sodium hyaluronate selected in the present invention does not cause adverse skin reactions, is milder, and is non-irritating to the skin.

[0102] In summary, the composition provided by the present invention has at least anti-wrinkle and dark circle improvement effects, and is mainly aimed at the problems of sagging, dullness, dark circles and other problems of mature skin around the eyes. Through the targeted design and combination of functional ingredients, Arabidopsis extract, red ball ginger extract, hydrolyzed ginsenosides and acetylated sodium hyaluronate components synergize with each other. Starting from the endogenous mechanism of aging and dark circles, by improving mitochondrial activity and respiration, enhancing cell activity metabolism, activating endogenous antioxidant pathways, fundamentally inhibiting inflammatory pathways, protecting capillaries, inhibiting collagen degradation signal pathways, promoting the expression of collagen and elastin, and enriching the extracellular matrix, the skin around the eyes can be tightened, the eye contour can be improved, the depth and area of wrinkles can be reduced, the pigment around the eyes can be decomposed, and the dark circles can be lightened. The composition of the present invention not only fills the gap in anti-wrinkle and dark circle improvement eye care products on the market, but also makes up for the defect of a single mechanism of action. The above four ingredients work synergistically with each other and are added according to the corresponding proportions to more comprehensively and significantly reduce the depth and area of wrinkles and improve dark circles without causing adverse skin reactions. It is very gentle and non-irritating to the skin.

[0103] It is understandable that the composition of the present invention can be made into cosmetics in other dosage forms, such as skin care water, skin care lotion, skin care cream, skin care gel, sunscreen milk / cream / gel / spray, etc. Within the ratio range disclosed in the present invention, the cosmetics in other dosage forms have similar effects as those demonstrated in the above embodiments of the present invention, are mild and non-irritating to human skin, and can have good firming and / or dark circle improvement effects.

[0104] The above specifically describes the preferred embodiments of the present invention, but the invention is not limited to the embodiments. Those skilled in the art may make various equivalent modifications or substitutions without violating the spirit of the present invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A composition, characterized in that In parts by weight, the composition comprises 0.02 to 0.4 parts of Arabidopsis thaliana extract, 0.005 to 0.015 parts of Zingiber officinale extract, 0.001 to 0.18 parts of hydrolyzed ginsenosides and 0.01 to 0.2 parts of acetylated sodium hyaluronate.

2. The composition according to claim 1, characterized in that The weight ratio of the Arabidopsis thaliana extract to the Zingiber officinale extract is 10-30:

1.

3. The composition according to claim 1, characterized in that The weight ratio of the acetylated sodium hyaluronate to the hydrolyzed ginsenosides is 2 to 10:

1.

4. The method for preparing the composition according to any one of claims 1 to 3, characterized in that: The following steps are involved: The Arabidopsis thaliana extract, the Zingiber officinale extract, the hydrolyzed ginsenosides and the acetylated sodium hyaluronate are mixed to obtain a composition.

5. Use of the composition according to any one of claims 1 to 3 in the preparation of cosmetics.

6. A cosmetic, characterized in that: The composition comprises the composition according to any one of claims 1 to 3.

7. The cosmetic according to claim 6, characterized in that The content of the composition is 0.001 to 10 wt%.

8. The cosmetic according to claim 6, characterized in that The cosmetics further include cosmetic base excipients, which include at least one of a thickener, a moisturizer, a softener, a pH regulator, a preservative, and a fragrance.

9. The cosmetic according to claim 6, characterized in that The cosmetics are eye cosmetics, which include essence, emulsion, eye gel, eye mask, eye shadow, gel or eye cream.

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