A hypertrophic obstructive cardiomyopathy treatment system

Abstract

The present invention discloses a treatment system for hypertrophic obstructive cardiomyopathy, including a mechanical injection device and a positioning detection device; the mechanical injection device includes an injection sleeve, an injection catheter is movably inserted in the injection sleeve, an injection needle is installed at one end of the injection catheter, the injection catheter is hollow inside and connected with the injection needle, a spiral is sleeved on the outside of the injection needle, and the spiral is fixed to the injection catheter; the positioning detection device includes: a cardiac ultrasound detection unit, an X-ray image detection unit, based on the current injection position image information and the preliminary positioning area information, a comparison is performed to determine whether the current injection position meets the requirements. The present invention screws the injection needle into the hypertrophic ventricular septum area through the superior vena cava route and injects anhydrous alcohol, causing local ventricular myonecrosis, relieving left ventricular outflow tract obstruction, and ensures that the area is located exactly in the middle of the ventricular septum through the positioning detection component, thereby improving positioning accuracy.

Description

Technical Field

[0001] The invention relates to the field of medical technology, and in particular to a hypertrophic obstructive cardiomyopathy treatment system. Background Art

[0002] Hypertrophic obstructive cardiomyopathy is a common cardiomyopathy in clinical practice. Hypertrophic ventricular septum induces SAM sign, leading to severe left ventricular outflow tract obstruction, which can cause chest pain, syncope and even sudden death in patients. Currently, the clinical drug treatment effect is not obvious. How to physically relieve the obstruction is an urgent problem to be solved in clinical practice.

[0003] At present, the main means of solving the problem clinically include surgical thoracotomy to remove part of the hypertrophic ventricular septum, injection of anhydrous alcohol through the septal branch of the coronary artery, and radiofrequency ablation catheter or radiofrequency ablation needle to damage the ventricular septum. However, there are many limitations, including large trauma, high complications, and insignificant effect, etc. At the same time, it is difficult to ensure that the injection area is exactly in the middle of the ventricular septum. In addition, in the prior art, the inferior cavity approach is used to vertically screw the perfusion catheter into the ventricular septum. This method is difficult to implement clinically and is difficult to operate. If anhydrous alcohol is injected into the myocardium through the perfusion side hole, the resistance will be relatively large, and it is difficult to accurately control the alcohol injection dose and the site of injury; in particular, the positioning of the injection site is difficult to control, which affects the injection effect. Therefore, the present invention proposes a hypertrophic obstructive cardiomyopathy treatment system to solve the above problems. Summary of the invention

[0004] In view of the above-mentioned defects in the prior art, the object of the present invention is to provide a hypertrophic obstructive cardiomyopathy treatment system.

[0005] To achieve the above object, the present invention provides a hypertrophic obstructive cardiomyopathy treatment system, comprising:

[0006] The mechanical injection device comprises an injection sleeve, an injection catheter is movably inserted in the injection sleeve, a contrast medium is contained in the injection catheter, an injection needle is installed at one end of the injection catheter, the injection catheter is hollow inside and communicated with the injection needle, a spiral is sleeved on the outside of the injection needle, the spiral is fixed to the injection catheter, and also comprises a syringe for injecting anhydrous alcohol into the ventricular septum through the injection catheter and the injection needle;

[0007] A positioning detection device is used to assist in detecting and locating the hypertrophic ventricular septum, the positioning detection device comprising:

[0008] Acquiring echocardiograms of the local myocardium before and after the injection of anhydrous alcohol respectively, and performing image processing on the echocardiograms of the local myocardium before and after the injection to obtain preliminary positioning area information, wherein the preliminary positioning area information includes the thickness and position of the local myocardium;

[0009] The X-ray image detection unit includes an X-ray transmitter, which is used to scan the ventricular septum after injection of anhydrous alcohol to obtain an X-ray contrast image, and obtain injection position image information based on the X-ray contrast image, wherein the injection position image information includes the current position information of the spiral and the current insertion depth of the injection needle.

[0010] Furthermore, a limit baffle is fixedly provided in the injection sleeve, a through hole is opened on the limit baffle, the injection catheter passes through the through hole, and a shaping guide wire is movably provided in the injection catheter; an injection tip is provided at one end of the injection sleeve on the same side as the spiral, a sealing tube is fixedly provided at one end of the injection sleeve away from the spiral, a sealing tube tip is provided at the front end of the sealing tube, and the spiral and the injection tip are fixedly connected or not connected.

[0011] Furthermore, when the spiral is not connected to the injection end, the spiral shrinks into the injection sleeve in a non-working state, a rotating column is inserted into the sealing tube end, the inner end of the rotating column is fixedly connected to the injection catheter, the interior of the rotating column is a hollow space, and also includes a clamping tool for clamping the rotating column for rotation, and the rotating column is rotated to drive the spiral and the injection needle to pass through the injection sleeve to form an injection state.

[0012] Furthermore, when the spiral is fixedly connected to the injection terminal, the spiral extends outward from the injection terminal for a distance that is the same as the length of the injection needle, and a screwing operation portion is formed on the outer peripheral surface of the injection terminal.

[0013] Furthermore, the injection sleeve adopts an electrode wire, including a cathode and an anode, and an impedance sensor, a sensing sensor and a threshold sensor are arranged at intervals on the inner wall of the injection sleeve near one end of the spiral, the impedance sensor is used to detect the body temperature value, the threshold sensor is used to detect the threshold and the electric pulse, and the sensing sensor is used to detect the local voltage level value;

[0014] Also included is a tester adapted to the injection sleeve, which senses the potential change of the myocardium through the injection sleeve and obtains the electrode parameters when the mechanical injection device is screwed into the ventricle;

[0015] The electrode parameters include the impedance value detected by the impedance sensor, the threshold and electric pulse value detected by the threshold sensor, the pacing threshold and the local voltage level value detected by the sensing sensor. The tester is electrically connected to the control and analysis unit, and transmits the acquired electrode parameters to the control and analysis unit in real time.

[0016] Furthermore, the control and analysis unit is also used to adjust the signal generation power of the impedance sensor, the perception sensor and the threshold sensor, including:

[0017] A first real-time monitoring module, used for real-time monitoring of the signal sending time and signal receiving time corresponding to the signal sent by the impedance sensor to the control and analysis unit;

[0018] A first communication duration acquisition module, used to acquire the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the impedance sensor to the control and analysis unit, and record the communication duration as the first communication duration;

[0019] A second real-time monitoring module is used to monitor in real time the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit;

[0020] A second communication duration acquisition module, used to obtain the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit, and record the communication duration corresponding to each signal obtained by the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit as the second communication duration;

[0021] A third real-time monitoring module is used to monitor in real time the signal sending time and signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit;

[0022] A third communication duration acquisition module, used to obtain the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit, and record the communication duration corresponding to each signal obtained by the signal sending time and signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit as the third communication duration;

[0023] The first communication duration parameter factor acquisition module is used to obtain the first communication duration parameter factor using the first communication duration, wherein the first communication duration parameter factor is obtained by the following formula:

[0024]

[0025] Among them, J 01 represents the first communication duration parameter factor; n represents the number of times the impedance sensor sends a signal to the control and analysis unit; G 01i represents the signal power corresponding to the signal sent by the i-th impedance sensor to the control and analysis unit; G fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 01i T represents the communication time corresponding to the signal sent by the i-th impedance sensor to the control and analysis unit; fmax Indicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; Tmax01 Indicates the maximum communication duration of the impedance sensor sending a signal to the control and analysis unit; G max01 Indicates the signal generation power of the impedance sensor corresponding to the maximum communication duration;

[0026] The second communication duration parameter factor acquisition module is used to acquire a second communication duration parameter factor using the second communication duration, wherein the second communication duration parameter factor is acquired by the following formula:

[0027]

[0028] Among them, J 02 represents the second communication duration parameter factor; m represents the number of times the perception sensor sends a signal to the control and analysis unit; G 02i G represents the signal generation power corresponding to the signal sent by the i-th perception sensor to the control and analysis unit; fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 02i T represents the communication duration corresponding to the signal sent by the i-th perception sensor to the control and analysis unit; fmax Indicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; T max02 Indicates the maximum communication duration of the perception sensor sending signals to the control and analysis unit; G max02 Indicates the signal generation power of the perception sensor corresponding to the maximum communication duration;

[0029] The third communication duration parameter factor acquisition module is used to obtain the third communication duration parameter factor using the third communication duration, and the third communication duration parameter factor is obtained by the following formula:

[0030]

[0031] Among them, J 03 represents the first communication duration parameter factor; q represents the number of times the threshold sensor sends a signal to the control and analysis unit; G 03i represents the signal power corresponding to the signal sent by the i-th threshold sensor to the control and analysis unit; G fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 03i T represents the communication duration corresponding to the signal sent by the threshold sensor to the control and analysis unit for the i-th time; fmax Indicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; T max03 Indicates the maximum communication duration of the threshold sensor sending a signal to the control and analysis unit; G max03Indicates the signal generation power of the threshold sensor corresponding to the maximum communication duration;

[0032] The signal generation power adjustment module is used to monitor in real time the difference between the first communication duration parameter factor, the second communication duration parameter factor, the third communication duration factor and the standard duration parameter factor. When the difference exceeds a preset difference threshold, the signal generation power of the impedance sensor and / or the perception sensor and / or the threshold sensor is adjusted.

[0033] Furthermore, the signal generation power adjustment module includes:

[0034] A parameter factor quantity relationship determination module, used to respectively monitor in real time the difference between the first communication duration parameter factor, the second communication duration parameter factor, the third communication duration factor and the standard duration parameter factor, and when the difference exceeds a preset difference threshold, retrieve the corresponding first communication duration parameter factor and / or the second communication duration parameter factor and / or the third communication duration parameter factor;

[0035] An adjustment target unit determination module is used to use the impedance sensor and / or perception sensor and / or threshold sensor corresponding to the retrieved corresponding first communication duration parameter factor and / or second communication duration parameter factor and / or third communication duration parameter factor as the adjustment target unit;

[0036] A signal generation power extraction module is used to extract the current signal generation power corresponding to the adjustment target unit;

[0037] A parameter factor retrieving module, used to retrieve the first communication duration parameter factor, the second communication duration parameter factor, or the third communication duration parameter factor corresponding to the adjustment target unit;

[0038] The target signal generation power acquisition module is used to obtain the adjusted signal generation power by using the current signal generation power corresponding to the adjustment target unit in combination with the first communication duration parameter factor or the second communication duration parameter factor or the third communication duration parameter factor corresponding to the adjustment target unit; wherein the adjusted signal generation power is obtained by the following formula:

[0039]

[0040] Among them, J 0x represents the xth communication duration parameter factor, x is 1 / 2 / 3, J O Represents the standard duration parameter factor, G m Indicates the signal power after adjustment; G c Indicates the signal power value corresponding to the target unit before signal power adjustment; J 01 represents the first communication duration parameter factor; J 02represents the second communication duration parameter factor; J 03 represents the third communication duration parameter factor; g represents the adjustment coefficient, and the adjustment coefficient is as follows:

[0041]

[0042] Among them, G fc Indicates the standard deviation of the signal power corresponding to the adjusted target unit; G f Indicates the maximum signal power floating value allowed to meet communication requirements; G x Indicates the signal power value corresponding to the non-adjustment target unit before the signal power adjustment;

[0043] The power adjustment execution module is used to adjust the signal generation power corresponding to the adjustment target unit according to the adjusted signal generation power.

[0044] Furthermore, the X-ray image detection unit also includes:

[0045] An image receiver is used to collect the fluorescence generated when the X-rays emitted by the X-ray emitter are irradiated on the contrast agent, and develop it with the help of a fluorescent screen to form an X-ray contrast image;

[0046] An image enhancement module, used for improving the contrast and clarity of X-ray contrast images by using image enhancement technology, so as to make the images of the spiral and / or injection needle more obvious;

[0047] An angle adjustment module for changing the angle of the X-ray source and the image receptor to observe the position and depth of the helix and / or injection needle from different directions to obtain a more comprehensive view;

[0048] The marking and measuring module is used to measure the current position information of the spiral on the X-ray angiography image and the insertion depth of the injection needle using a ruler and a marking tool to form injection position image information.

[0049] Furthermore, it also includes an arterial pressure measuring unit, which is used to obtain the pressure difference of the left ventricular outflow tract before and after the injection of anhydrous alcohol, and obtain the pressure difference detection value. The arterial pressure measuring unit includes an invasive direct arterial pressure measurement module, and the invasive direct arterial pressure measurement module includes a blood pressure monitor and a catheter connected to the blood pressure monitor.

[0050] Furthermore, the cardiac cavity ultrasound detection unit comprises:

[0051] A probe positioning module, comprising a probe, wherein the probe is delivered into the heart cavity through a peripheral vein and is aimed at a target myocardial area, and the probe emits a short-wave ultrasound beam;

[0052] A real-time imaging module receives ultrasound waves reflected in the heart cavity and forms a real-time two-dimensional or three-dimensional echocardiogram through electrical signal processing;

[0053] The image processing module obtains a two-dimensional or three-dimensional echocardiogram and measures myocardial parameter information based on the echocardiogram, wherein the myocardial parameter information includes the thickness and position of the myocardium.

[0054] Compared with the prior art, the present invention has the following beneficial effects:

[0055] 1. The present invention screws the injection needle into the hypertrophic ventricular septum area through the superior vena cava, and injects anhydrous alcohol into the area through the injection needle, and ensures that the area is located exactly in the middle of the ventricular septum through the positioning detection component. Anhydrous alcohol will cause local myocardial damage, thereby relieving outflow tract obstruction. At the same time, due to the limitation of the injection area, it will not spread around, so there will be no large-area myocardial damage, avoiding damage to the myocardial conduction system, effectively controlling the hidden dangers of large trauma and complications, with higher safety and more obvious effects;

[0056] 2. The present invention, through the modification of the mechanical injection device, adds an injection needle 7 which is coaxially arranged with the spiral. In the process of the spiral piercing into the ventricular septum area, the spiral is vertically screwed into the hypertrophic ventricular septum area through the superior vena cava, playing an anchoring role. At the same time, the injection needle is also inserted into the hypertrophic ventricular septum area, and then anhydrous alcohol is injected into the hypertrophic ventricular septum area through the injection needle. Anhydrous alcohol can be injected into multiple parts, multiple times, and in different doses. The injection of anhydrous alcohol through the injection needle has relatively small resistance, controllable damage range, high safety, and low complications, thus creating a minimally invasive, safe, and reliable surgical procedure for treating hypertrophic obstructive cardiomyopathy;

[0057] 3. The present invention detects the blood pressure activity of the patient's heart before injecting anhydrous alcohol through an arterial pressure measuring unit, obtains the arterial pressure detection value, and determines whether the myocardium has been necrotic; before the injection needle is inserted, an echocardiogram is obtained through a cardiac ultrasound detection unit, so as to facilitate the determination of the position where the needle needs to be inserted before injection to avoid deviation, and obtain preliminary positioning area information of the hypertrophic myocardium of the ventricular septum based on the echocardiogram; after the injection needle is inserted, the position of the mechanical injection device and the insertion depth of the spiral are detected in real time through an X-ray image detection unit, and the current condition of the myocardium and the changes before and after the injection of alcohol are determined through an electrode detection device to ensure that the area is located exactly in the middle of the ventricular septum. Anhydrous alcohol will cause local myocardial damage, thereby relieving outflow tract obstruction. At the same time, due to the limitation of the injection area, it will not spread around, so there will be no large-scale myocardial damage, and damage to the myocardial conduction system is avoided, effectively controlling the hidden dangers of large trauma and complications, with higher safety and more obvious effects; BRIEF DESCRIPTION OF THE DRAWINGS

[0058] In order to more clearly illustrate the scheme in the present invention, a brief introduction is given below to the drawings required for use in the description of the embodiments of the present invention. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0059] Figure 1 It is a schematic diagram of the positioning detection device system provided by the present invention;

[0060] Figure 2 This is a schematic diagram of the structure of the spiral extension of the first embodiment provided by the present invention;

[0061] Figure 3 This is a schematic diagram of the structure of the spiral contraction of the first embodiment provided by the present invention;

[0062] Figure 4 It is a structural schematic diagram of the second embodiment provided by the present invention;

[0063] Figure 5 It is a schematic diagram of the cardiac cavity ultrasound detection steps provided by the present invention;

[0064] Figure 6 It is a schematic diagram of the X-ray image detection steps provided by the present invention;

[0065] Figure 7 This is a front view of the first embodiment of the present invention when the spiral is contracted;

[0066] Figure 8 This is a front view of the first embodiment of the present invention when the spiral is extended;

[0067] Fig. 9 This is a front view of the second embodiment provided by the present invention;

[0068] Fig.10 This is a usage state diagram of the first embodiment provided by the present invention;

[0069] Fig.11 This is a usage state diagram of the second embodiment provided by the present invention;

[0070] Fig.12 It is a schematic diagram of the injection device of the present invention piercing the interventricular septum.

[0071] Description of reference numerals:

[0072] 1. Injection sleeve; 101. 3D sheath; 2. Limit baffle; 3. Injection catheter; 4. Injection tip; 5. Spiral; 6. Fixing plate; 7. Injection needle; 701. Syringe; 8. Sealing tube; 9. Sealing tube tip; 10. Rotating column; 11. Clamping tool; 12. Shaped guide wire. DETAILED DESCRIPTION

[0073] The preferred embodiments of the present invention are described in detail below in conjunction with the accompanying drawings so that the advantages and features of the present invention can be more easily understood by those skilled in the art, thereby making a clearer and more explicit definition of the protection scope of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work belong to the scope of protection of the present invention.

[0074] The terms "including" and "having" and any variations thereof in the specification and claims of the present invention and the above-mentioned drawings are intended to cover non-exclusive inclusions. The terms "first", "second", etc. in the specification and claims of the present invention or the above-mentioned drawings are used to distinguish different objects rather than to describe a specific order.

[0075] See also Figure 1 , Figure 2-3 , Figure 7 and Figure 8 A treatment system for hypertrophic obstructive cardiomyopathy, comprising a mechanical injection device and a positioning detection device; wherein the mechanical injection device comprises an injection sleeve 1, wherein an injection catheter 3 is movably inserted in the injection sleeve 1, and specifically, a limit baffle 2 is fixedly arranged in the injection sleeve 1, and a through hole is opened on the limit baffle 2, and the injection catheter 3 passes through the through hole, and the setting of the through hole can ensure that the injection catheter 3 passes through, and can limit its position within a certain range to avoid large-scale shaking. An injection needle 7 for injecting anhydrous alcohol into the ventricular septum is installed at one end of the injection catheter 3, the injection catheter 3 is hollow inside and connected to the injection needle 7, and a spiral 5 is set on the outside of the injection needle 7, and the spiral 5 is fixed to the injection catheter 3, and anhydrous alcohol can be introduced through the injection catheter 3, and also includes a syringe for injecting anhydrous alcohol into the ventricular septum through the injection catheter 3 and the injection needle 7; wherein the anhydrous alcohol is generally injected into the injection catheter 3 through an external syringe, and the anhydrous alcohol is then injected into the hypertrophic ventricular septum area through the injection needle 7.

[0076] The injection sleeve 1 can use an electrode wire. During the process of inserting into the ventricle, an injection needle 7 is added, and anhydrous alcohol can be injected into the injection sleeve 1 through the syringe 701. The anhydrous alcohol is injected into a specific position through the injection needle 7, and local treatment is performed on the area of ​​myocardial damage. The injection of anhydrous alcohol into the area will cause local myocardial damage, thereby achieving the purpose of relieving outflow tract obstruction. The setting of the spiral 5 can drive the entire injection sleeve 1 to be screwed into the ventricle. The present invention enters the right ventricle through the superior vena cava route, and vertically screws the spiral 5 into the hypertrophic ventricular septum area or the SAM sign area through the superior vena cava route, which plays an anchoring role. At the same time, the injection needle 7 is also inserted into the inside of the hypertrophic ventricular septum area. Under the above-mentioned anchoring effect, the injection needle can be fixed in the area, so that it is convenient for the injection needle 7 to inject anhydrous alcohol and complete the injection.

[0077] Since the injection sleeve 1 and the injection catheter 3 are generally bendable to a certain extent, before entering the right ventricle through the superior vena cava, a shaping guide wire needs to be movably arranged in the injection catheter 3. The shaping guide wire is made of metal wire, which has a certain shaping effect during the process of piercing the ventricle, making it easier to pierce. Fig.12 Generally, before the injection device is inserted into the myocardium, a 3D sheath 101 needs to be mounted on the outside of the injection sleeve 1, and the 3D sheath 101 plays a role in transmission. An injection terminal 4 is provided at one end of the injection sleeve 1 on the same side as the spiral 5, and a sealing tube 8 is fixedly provided at the end of the injection sleeve 1 away from the spiral 5. A sealing tube terminal 9 is provided at the front end of the sealing tube 8. The injection terminal 4 and the sealing tube terminal 9 are equivalent to the two ends of the entire injection sleeve 1. When anhydrous alcohol needs to be injected, it is generally injected into the injection sleeve 1 from one side of the sealing tube terminal 9 through the syringe 701. During the injection process, the injection pressure of the syringe 701 can make the anhydrous alcohol injected into the ventricular septum through the distal injection needle 7. The spiral 5 and the injection terminal 4 are fixedly connected or not connected. The fixed connection and not connected form two different operation modes of piercing the ventricle.

[0078] In one embodiment, see Figure 2 and Figure 3 When the spiral 5 is not connected to the injection end 4, the spiral 5 is retracted into the injection sleeve 1 in the non-working state, and a rotating column 10 is inserted into the sealing tube end 9. The inner end of the rotating column 10 is fixedly connected to the injection catheter 3. The interior of the rotating column 10 is arranged in a cavity, and also includes a clamping tool 11 for clamping the rotating column 10 for rotation. The rotating column 10 is rotated clockwise to drive the spiral 5 and the injection needle 7 to pass through the injection sleeve 1 to form an injection state. In this embodiment, the spiral 5 is in a retracted state when not in operation, which can ensure the sanitation and safety of the spiral 5 to a certain extent. The spiral 5 is screwed into the ventricle by rotating the clamping tool 11, which is convenient for operation.

[0079] In another embodiment, see Figure 4 and Fig. 9 When the spiral 5 is fixedly connected to the injection terminal 4, the spiral 5 extends outward from the injection terminal 4 for a distance, and the extension distance is the same as the length of the injection needle 7, and a screwing operation portion is formed on the outer peripheral surface of the injection terminal 4. The spiral 5 and the injection needle 7 of this embodiment are always at the outer end of the injection terminal 4, and can be directly inserted into the ventricle without being screwed out by the rotating column 10. Therefore, the outer end of the injection catheter 3 of this embodiment does not include the rotating column 10 and the clamping tool 11, and it is not necessary to clamp and rotate the rotating column 10 to insert into the ventricle. However, in the process of delivering to the ventricular septum, the shaping of the shaping guide wire is also required, and the 3D sheath 101 needs to be sleeved on the outside of the injection sleeve 1 for delivery.

[0080] When the spiral 5 needs to be screwed into the ventricle, the medical staff only needs to hold the screwing operation part of the injection terminal 4, screw the spiral 5, and drive the entire injection device to rotate in the outer sheath 101 through the superior vena cava route, and with the support of the outer sheath 101, the spiral 5 is connected to the injection needle 7 and inserted into the hypertrophic ventricular septum area (see Fig.12 ), then inject anhydrous alcohol into the injection sleeve 1 through the syringe 701, and then complete the injection through the injection needle. This injection method of injecting anhydrous alcohol through the injection needle can cause effective local myocardial damage, the damage range is controllable, and the anhydrous alcohol diffusion area is avoided. It effectively controls the hidden dangers of large trauma, complications, etc., and is safer. Figure 2 and Figure 3 An embodiment of Figure 4 It is another operation mode, which simplifies the operation steps.

[0081] In order to preliminarily determine whether the myocardium has been necrotic before injecting anhydrous alcohol and to provide preliminary guidance for the injection, the treatment system of the present invention also includes an arterial pressure measurement unit for obtaining the pressure difference of the left ventricular outflow tract before and after the injection of anhydrous alcohol to obtain a pressure difference detection value.

[0082] The arterial pressure measurement unit mainly includes an invasive direct arterial pressure measurement module, and the invasive direct arterial pressure measurement module includes a blood pressure monitor and a catheter connected to the blood pressure monitor. In the above technical scheme, the catheter can be a pigtail catheter, which is introduced above and below the aortic valve to measure the pressure. After myocardial injury, the locally hypertrophic ventricular septum becomes thinner and / or the contractility decreases, the local outflow tract obstruction is relieved or alleviated, and the pressure difference above and below the aortic valve will decrease significantly. By detecting the pressure difference in the left ventricular outflow tract before and after the injection of anhydrous alcohol, the pressure difference detection value is obtained, which can assist in judging the myocardial injury after injection.

[0083] Before inserting spiral 5 into the ventricular septum for injection, it is necessary to ensure that the position where spiral 5 is inserted is in the hypertrophic ventricular septum to avoid affecting the injection effect due to deviation in the position. For this reason, the cardiomyopathy treatment system of the present invention also includes a positioning detection device for assisting in detecting and locating the hypertrophic ventricular septum to ensure the accuracy of injection by injection needle 7.

[0084] The positioning detection device comprises:

[0085] The cardiac cavity ultrasound detection unit obtains the ultrasound cardiograms of the local myocardium before and after the injection of anhydrous alcohol, and performs image processing on the ultrasound cardiograms of the local myocardium before and after the injection to obtain preliminary positioning area information, wherein the preliminary positioning area information includes the thickness and position of the local myocardium;

[0086] The X-ray image detection unit includes an X-ray emitter, which is used to scan the interventricular septum after injection of anhydrous alcohol to obtain an X-ray contrast image, and obtain injection position image information based on the X-ray contrast image, wherein the injection position image information includes the current position information of the spiral 5 and the current insertion depth of the injection needle 7.

[0087] In the above technical solution, the echocardiogram of the local myocardium before and after the injection of anhydrous alcohol is obtained by the cardiac cavity ultrasonic detection unit. The echocardiogram uses ultrasound to display the heart structure. The echocardiogram performs image processing to obtain the thickness and position information of the local myocardium to form preliminary positioning area information. The image processing includes the steps of image segmentation, feature extraction, target recognition, etc. for the echocardiogram to extract and obtain the thickness and position of the local myocardium. The position of the local myocardium can be coordinate information. The steps of image segmentation, feature extraction, target recognition, etc. are commonly used image processing techniques. The existing technology that can be implemented can be used to obtain preliminary positioning area information, and no further description is given.

[0088] Based on echocardiography, the preliminary positioning area information of the ventricular septal hypertrophy myocardium is further locked, and the preliminary positioning area information can be used to obtain the location where the needle injection is required from a three-dimensional perspective.

[0089] At the same time, the ventricular septum after injection of anhydrous alcohol is scanned by an X-ray image detection unit to obtain an X-ray angiography image, and the injection position image information is obtained based on the X-ray angiography image. The injection position image information includes the current position information of the spiral 5 and the current insertion depth of the injection needle 7, which is convenient for positioning and monitoring the insertion and injection position of the injection needle 7 and the spiral 5, ensuring that the operation injection position is at the hypertrophic ventricular septum position, assisting in real-time tracking and adjustment, and ensuring the reliability of the operation.

[0090] The principle and effect of the above technical solution are that in the treatment system of hypertrophic obstructive cardiomyopathy, a mechanical injection device and a positioning detection device are included at the same time. Before the injection, the cardiac cavity ultrasound detection unit is used to collect the condition of the myocardium, and an echocardiogram before the injection of anhydrous alcohol is obtained. The preliminary positioning area information is obtained through the echocardiogram, and the insertion direction of the spiral 5 when it is inserted into the ventricle and the injection position of the injection needle 7 are obtained by assisting the medical staff through the preliminary regional information. The X-ray emitter of the X-ray image detection unit scans the ventricular septum after the injection of anhydrous alcohol to obtain an X-ray contrast image, and obtains the current position information of the spiral 5 and the current insertion depth of the injection needle 7. The acquisition of the above parameter information can be used as reference data for auxiliary medical treatment. Medical staff can adjust the injection position according to this reference data to improve the accuracy of the injection position. After the injection, the cardiac cavity ultrasound detection unit is used to collect the condition of the myocardium, and an echocardiogram after the injection of anhydrous alcohol is obtained. By comparing the echocardiogram after the injection with the echocardiogram before the injection, it can be used to assist in judging the changes in the myocardium, thereby judging the effect of the injection.

[0091] The above technical solution can inject anhydrous alcohol into the hypertrophic ventricular septum area through a mechanical injection device. Anhydrous alcohol can be injected locally in multiple locations, multiple times, and in different doses. The damage range is controllable and safe. Anhydrous alcohol will cause local myocardial damage, thereby relieving outflow tract obstruction. At the same time, due to the limitation of the injection area, it will not spread around, so there will be no large-scale myocardial damage, avoiding damage to the myocardial conduction system, effectively controlling hidden dangers such as large trauma and complications, with higher safety and more obvious effects, creating a minimally invasive, safe, and reliable surgical procedure for treating hypertrophic obstructive cardiomyopathy. At the same time, the positioning detection device assists in obtaining the thickness and position of the local myocardium, as well as the current position information of the spiral 5 after injection and the current insertion depth of the injection needle 7, thereby improving the accuracy of positioning.

[0092] Furthermore, the cardiac cavity ultrasound detection unit includes:

[0093] The probe positioning module includes a probe, which is sent into the heart cavity through a peripheral vein. The probe emits a short-wave ultrasound beam, and the position and angle of the probe are adjusted to aim at the target myocardial area; the target myocardial area here refers to the hypertrophic ventricular septum area;

[0094] The real-time imaging module receives ultrasound waves reflected in the heart cavity and forms a real-time two-dimensional or three-dimensional echocardiogram through electrical signal processing. Specifically, the probe emits a short-wave ultrasound beam, which passes through various layers of heart tissue. The reflected echo is received in the gap between the probe emitting ultrasound waves, converted into electrical energy through the positive piezoelectric effect, and then displayed on the fluorescent screen as light spots of varying strengths after detection and amplification. The ultrasonic pulses continuously penetrate the tissues and generate echoes. The sound waves reflected back at different times are displayed on the fluorescent screen as a series of longitudinally arranged light spots according to the order of the reflection interfaces. The horizontal deflection plate of the slow scanning circuit causes the longitudinally arranged light spots to scan from left to right on the oscilloscope screen, presenting continuously fluctuating curves and graphs, which is an echocardiogram.

[0095] The image processing module obtains a two-dimensional or three-dimensional echocardiogram and measures myocardial parameter information based on the echocardiogram, wherein the myocardial parameter information includes the thickness and position of the myocardium.

[0096] The above technical solution uses a probe for multi-angle observation. The cardiac cavity ultrasound probe can rotate and bend at multiple angles, providing viewing angles of different parts of the heart, and can quickly align with the target myocardial area. The real-time imaging module can process the reflected ultrasound waves into a real-time two-dimensional or three-dimensional echocardiogram through electrical signal processing, and obtain myocardial parameters such as myocardial thickness and position by image processing of the echocardiogram. It is helpful to comprehensively evaluate myocardial parameters such as myocardial thickness and position, so as to obtain preliminary positioning area information. The use of cardiac cavity ultrasound detection improves the accuracy of positioning before anhydrous alcohol injection, facilitates medical staff to quickly locate, and obtains an echocardiogram of the local myocardium after anhydrous alcohol injection, which is convenient for comparison with the echocardiogram before injection, and can be used to assist in judging changes in the myocardium, thereby judging the effect of the injection.

[0097] Furthermore, the X-ray image detection unit is used to detect the position of the spiral 5 and the insertion depth of the injection needle 7 and the insertion depth of the spiral 5 during or after injection. Since contrast agent is loaded inside the injection catheter 3, it is equivalent to loading contrast agent before loading anhydrous alcohol. During the injection process, the contrast agent can be squeezed and pushed into the position of the myocardium such as the ventricular septum. Positioning can be achieved through X-ray image detection, and the local needle puncture situation and the diffusion of anhydrous alcohol can be accurately judged. The X-ray image detection unit includes:

[0098] An image receiver is used to collect the fluorescence generated when the X-rays emitted by the X-ray emitter are irradiated on the contrast agent, and develop it with the help of a fluorescent screen to form an X-ray contrast image;

[0099] An image enhancement module, used to improve the contrast and clarity of the X-ray angiography image by using image enhancement technology, so that the image of the spiral 5 and / or the injection needle 7 is more obvious;

[0100] An angle adjustment module for changing the angles of the X-ray source and the image receptor to observe the position and depth of the spiral 5 and / or the injection needle 7 from different directions to obtain a more comprehensive view;

[0101] The marking and measuring module is used to measure the current position information of the spiral 5 and the insertion depth of the injection needle 7 on the X-ray angiography image using a ruler and a marking tool to form injection position image information.

[0102] The above technical solution adopts X-ray image detection technology. The fluorescent agent is loaded into the injection catheter 3. During the injection of anhydrous alcohol, part of the fluorescent agent will be pushed into the myocardium along with the injection of the injection needle 7. The injection needle 7 and the spiral 5 are inserted synchronously. Therefore, the position of the fluorescent agent at this time is basically the same as the position of the injection needle 7 and / or the spiral 5. After the X-ray emitter emits X-rays, the fluorescent agent will emit fluorescence. At this time, the position of the fluorescent agent is equivalent to the position of the spiral and / or the injection needle 7, thereby achieving positioning. The image receiver collects the fluorescence generated when the X-rays emitted by the X-ray transmitter are irradiated on the contrast agent, and develops it with the help of a fluorescent screen to obtain an X-ray contrast image. The image enhancement module is then used to improve the contrast and clarity of the X-ray contrast image, making it easier to identify subtle positions and differences. During the image acquisition process, the angle between the X-ray source and the image receiver is changed through the angle adjustment module to facilitate better positioning and acquisition of a comprehensive image. The position and depth of the spiral 5 and / or the injection needle 7 on the X-ray contrast image are marked through the marking and measurement module, so that the insertion of the spiral 5 can be objectively grasped to form injection position image information. The injection position image information is convenient for hospital personnel to assist in determining whether the injection position belongs to the target myocardial area, thereby improving the accuracy of needle insertion.

[0103] Furthermore, the injection sleeve 1 of the present invention may also use an electrode wire or a product made of the same material as the electrode wire to achieve the function of electrode detection during the insertion process, and the electrode wire includes a cathode and an anode. Under this premise, in order to improve the comprehensiveness and accuracy of positioning, the positioning detection device of the present invention also includes:

[0104] The detection sensor comprises an impedance sensor, a sensing sensor and a threshold sensor which are arranged at intervals on the outer wall of the injection sleeve 1 near the spiral 5, the impedance sensor is used to detect the impedance value of the local myocardium, the sensing sensor is used to detect the voltage level of the local myocardium, and the threshold sensor is used to detect the minimum amplitude of the local current output to capture the myocardium; when the mechanical injection device is screwed into the ventricle, the potential change of the myocardium is sensed by the impedance sensor, the sensing sensor and the threshold sensor to obtain the sensor parameters;

[0105] The control and analysis unit is electrically connected to the above-mentioned detection sensors, and is used to receive the detected sensor parameter values, including the impedance value of the local myocardium, the local myocardial voltage level and the minimum amplitude of the local current output to capture the myocardium, and compare the sensor parameters with the sensor parameter thresholds;

[0106] The output display unit includes a display screen, and is used to output and display the analysis result of the control and analysis unit through the display screen.

[0107] During or after the injection catheter 3 is screwed into the ventricular septum through the mechanical injection device, different sensor parameters can be detected by the detection sensor. The different sensor parameters are analyzed and compared by the control analysis unit, compared with the preset sensor parameter threshold, and the analysis results are displayed on the display screen through the output display unit. Medical staff can assist in locating the position of the ventricular septum, judge the current condition of the myocardium, and the changes before and after the injection of anhydrous alcohol by understanding the changes in sensor parameters.

[0108] The specific working process is that the impedance value detected by the impedance sensor can assist in judging whether the fit between the injection sleeve 1 and the myocardium is tightly fitted. The impedance sensor detects the local impedance value on the injection sleeve 1. This impedance value reflects the fit of the injection sleeve 1 after it is screwed into the myocardium, and is used to judge whether the injection sleeve 1 after the spiral 5 is inserted is well attached to the myocardium. If the impedance value displayed is relatively large, it proves that the fit is relatively good; if the injection sleeve 1 is screwed through the ventricular septum or screwed too much and screwed to the left ventricle, the displayed impedance value will be very low, proving that it is not well fitted; if the injection sleeve 1 is not screwed deeply and is not screwed to the position, the spiral 5 injection needle 7 of the injection sleeve 1 does not reach the position of the hypertrophic ventricular septum, and it is also not well fitted. In this case, the displayed impedance value will be very low, and there is also a problem. This is a judgment parameter that reflects whether the injection sleeve 1 is firmly screwed to the ventricular septum and whether there is a good fit. The maximum threshold and minimum threshold of the preset impedance value are used, and the range beyond the maximum threshold or the minimum threshold is used as an evaluation standard for determining that there is no firm fit.

[0109] After the injection of anhydrous alcohol, the impedance value can also be used to judge the damage of the myocardium. The specific principle is: after the injection of anhydrous alcohol, the myocardium will be damaged and then atrophy. At this time, because the fit is not tight, the current resistance is very large, and the displayed impedance value will become lower.

[0110] The local voltage level detected by the sensing sensor is used to judge the health of the local myocardium. When the myocardium is hypertrophic, the local myocardial voltage is high. After the injection of anhydrous alcohol, the local myocardium is damaged or atrophied, causing the local myocardial voltage to decrease.

[0111] The local current output detected by the threshold sensor captures the minimum amplitude value of the myocardium. When the myocardium is hypertrophic, the current of the local myocardium is small, and the minimum amplitude value of the local current output that captures the myocardium is relatively small. After the injection of anhydrous alcohol, the local myocardium is damaged or atrophied. At this time, the voltage of the local myocardium is reduced, and more current needs to be output. The current value of the local myocardium increases, and the corresponding minimum amplitude value of the local current output that captures the myocardium becomes larger.

[0112] The electrode parameter values ​​detected above can, to a certain extent, be used as reference parameter values ​​to assist in judging the condition of the myocardium, as well as the changes before and after the injection of alcohol. On the one hand, as the spiral 5 and the injection needle 7 are screwed into different depths, the parameter values ​​output by the impedance sensor, perception sensor and threshold sensor at the head end will change. On the other hand, after the injection of alcohol, the impedance sensor, perception sensor and threshold sensor at the electrode head end will also change, thereby indirectly reflecting the degree of damage. The sensor parameter values ​​of the above impedance sensor, perception sensor and threshold sensor are transmitted to the control and analysis unit in real time, and an intelligent comparison is performed between the control and analysis unit and the preset sensor parameter threshold. The judgment result can be used as reference data and displayed on the display screen, so that medical staff can obtain it in a timely manner.

[0113] Furthermore, since the sensor parameter values ​​are acquired in real time, the control and analysis unit is also used to adjust the signal generation power of the impedance sensor, the perception sensor and the threshold sensor, including:

[0114] A first real-time monitoring module, used for real-time monitoring of the signal sending time and signal receiving time corresponding to the signal sent by the impedance sensor to the control and analysis unit;

[0115] A first communication duration acquisition module, used to acquire the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the impedance sensor to the control and analysis unit, and record the communication duration as the first communication duration;

[0116] A second real-time monitoring module is used to monitor in real time the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit;

[0117] A second communication duration acquisition module, used to obtain the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit, and record the communication duration corresponding to each signal obtained by the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit as the second communication duration;

[0118] A third real-time monitoring module is used to monitor in real time the signal sending time and the signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit;

[0119] A third communication duration acquisition module, used to obtain the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit, and record the communication duration corresponding to each signal obtained by the signal sending time and signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit as the third communication duration;

[0120] The first communication duration parameter factor acquisition module is used to obtain the first communication duration parameter factor using the first communication duration, wherein the first communication duration parameter factor is obtained by the following formula:

[0121]

[0122] Among them, J 01 represents the first communication duration parameter factor; n represents the number of times the impedance sensor sends a signal to the control and analysis unit; G 01i represents the signal power corresponding to the signal sent by the i-th impedance sensor to the control and analysis unit; G fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 01i T represents the communication time corresponding to the signal sent by the i-th impedance sensor to the control and analysis unit; fmax Indicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; T max01 Indicates the maximum communication duration of the impedance sensor sending a signal to the control and analysis unit; G max01 Indicates the signal generation power of the impedance sensor corresponding to the maximum communication duration;

[0123] The second communication duration parameter factor acquisition module is used to acquire a second communication duration parameter factor using the second communication duration, wherein the second communication duration parameter factor is acquired by the following formula:

[0124]

[0125] Among them, J 02 represents the second communication duration parameter factor; m represents the number of times the perception sensor sends a signal to the control and analysis unit; G 02i G represents the signal generation power corresponding to the signal sent by the i-th perception sensor to the control and analysis unit; fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 02i T represents the communication duration corresponding to the signal sent by the i-th perception sensor to the control and analysis unit; fmaxIndicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; T max02 Indicates the maximum communication duration of the perception sensor sending signals to the control and analysis unit; G max02 Indicates the signal generation power of the perception sensor corresponding to the maximum communication duration;

[0126] The third communication duration parameter factor acquisition module is used to obtain the third communication duration parameter factor using the third communication duration, and the third communication duration parameter factor is obtained by the following formula:

[0127]

[0128] Among them, J 03 represents the first communication duration parameter factor; q represents the number of times the threshold sensor sends a signal to the control and analysis unit; G 03i represents the signal power corresponding to the signal sent by the i-th threshold sensor to the control and analysis unit; G fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 03i T represents the communication duration corresponding to the signal sent by the threshold sensor to the control and analysis unit for the i-th time; fmax Indicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; T max03 Indicates the maximum communication duration of the threshold sensor sending a signal to the control and analysis unit; G max03 Indicates the signal generation power of the threshold sensor corresponding to the maximum communication duration;

[0129] The signal generation power adjustment module is used to monitor in real time the difference between the first communication duration parameter factor, the second communication duration parameter factor, the third communication duration factor and the standard duration parameter factor. When the difference exceeds a preset difference threshold, the signal generation power of the impedance sensor and / or the perception sensor and / or the threshold sensor is adjusted.

[0130] The technical effect of the above technical solution is: through the first, second and third real-time monitoring modules, the system can obtain the signal sending time and receiving time sent by the impedance sensor, perception sensor and threshold sensor to the control analysis unit in real time. This not only ensures the real-time nature of the data, but also provides a basis for the subsequent calculation of the communication duration. Using the first, second and third communication duration acquisition modules, the system can further calculate the communication duration of each signal transmission (referred to as the first, second and third communication durations, respectively), which is crucial for evaluating the efficiency, stability and reliability of signal transmission.

[0131] Through the first, second and third communication duration parameter factor acquisition modules, the system can calculate parameter factors (J01, J02 and J03) that reflect the communication quality based on multiple factors such as communication duration and signal generation power. These parameter factors comprehensively consider multiple dimensions of signal transmission, such as signal strength, transmission time, etc., and can more comprehensively reflect the performance of the communication system.

[0132] The design of the signal generation power adjustment module is one of the highlights of this technical solution. By real-time monitoring the difference between the first, second and third communication duration parameter factors and the standard duration parameter factors, and comparing them with the preset difference threshold, the system can automatically determine whether the current communication status needs to be adjusted. When the difference exceeds the threshold, the system can intelligently adjust the signal generation power of the impedance sensor, perception sensor and threshold sensor to optimize the communication quality and reduce the risk of signal interference or loss, thereby improving the stability and reliability of the entire system.

[0133] Since this technical solution can monitor and adjust the communication quality in real time, it ensures that key medical data such as electrode parameters can be accurately and timely transmitted to the control and analysis unit, which is of great significance for doctors to make timely and accurate medical diagnoses. It reduces the risk of misdiagnosis or missed diagnosis caused by communication problems and improves the quality and efficiency of medical services.

[0134] The modular design of this technical solution makes the system easy to expand and maintain. In the future, more monitoring units can be added or communication strategies can be adjusted as needed to meet the needs of different medical application scenarios. At the same time, the modular design also reduces the complexity and cost of the system and improves the flexibility and availability of the system.

[0135] Furthermore, the signal generation power adjustment module includes:

[0136] A parameter factor quantity relationship determination module, used to respectively monitor in real time the difference between the first communication duration parameter factor, the second communication duration parameter factor, the third communication duration factor and the standard duration parameter factor, and when the difference exceeds a preset difference threshold, retrieve the corresponding first communication duration parameter factor and / or the second communication duration parameter factor and / or the third communication duration parameter factor;

[0137] An adjustment target unit determination module is used to use the impedance sensor and / or perception sensor and / or threshold sensor corresponding to the retrieved corresponding first communication duration parameter factor and / or second communication duration parameter factor and / or third communication duration parameter factor as the adjustment target unit;

[0138] A signal generation power extraction module is used to extract the current signal generation power corresponding to the adjustment target unit;

[0139] A parameter factor retrieving module, used to retrieve the first communication duration parameter factor, the second communication duration parameter factor, or the third communication duration parameter factor corresponding to the adjustment target unit;

[0140] The target signal generation power acquisition module is used to obtain the adjusted signal generation power by using the current signal generation power corresponding to the adjustment target unit in combination with the first communication duration parameter factor or the second communication duration parameter factor or the third communication duration parameter factor corresponding to the adjustment target unit; wherein the adjusted signal generation power is obtained by the following formula:

[0141]

[0142] Among them, J 0x represents the xth communication duration parameter factor, x is 1 / 2 / 3, J O Represents the standard duration parameter factor, G m Indicates the signal power after adjustment; G c Indicates the signal power value corresponding to the target unit before signal power adjustment; J 01 represents the first communication duration parameter factor; J 02 represents the second communication duration parameter factor; J 03 represents the third communication duration parameter factor; g represents the adjustment coefficient, and the adjustment coefficient is as follows:

[0143]

[0144] Among them, G fc Indicates the standard deviation of the signal power corresponding to the adjusted target unit; G f Indicates the maximum signal power floating value allowed to meet communication requirements; G x Indicates the signal power value corresponding to the non-adjustment target unit before the signal power adjustment;

[0145] The power adjustment execution module is used to adjust the signal generation power corresponding to the adjustment target unit according to the adjusted signal generation power.

[0146] The technical effect of the above technical solution is: the difference between the first, second and third communication duration parameter factors and the standard duration parameter factor is monitored in real time through the parameter factor quantity relationship determination module, and the adjustment mechanism is triggered when it exceeds the preset threshold, ensuring that the system can respond quickly to changes in communication quality. This dynamic adjustment mechanism helps maintain the stability and reliability of the communication system.

[0147] The adjustment target unit determination module determines the impedance sensor, perception sensor or threshold sensor that needs to be adjusted according to the minimum value of the parameter factor, which reflects the intelligence of the system. By selecting the unit that needs to be optimized most for adjustment, the overall communication quality can be more effectively improved.

[0148] The target signal power acquisition module uses the current signal power and communication duration parameter factors, combined with the adjustment coefficient to calculate the adjusted signal power. This adjustment strategy not only takes into account the current communication status, but also incorporates historical data and system characteristics (such as the standard deviation of signal power and the maximum allowed signal power floating value), making the adjustment result more reasonable and reliable.

[0149] The design of the adjustment coefficient takes into account multiple factors, such as the standard deviation of signal power, the maximum allowed signal power fluctuation value, and the signal power of non-adjustment target units. This allows the adjustment coefficient to be flexibly adjusted according to different situations, thereby ensuring that the adjusted signal power meets the communication requirements without causing excessive burden on the system.

[0150] By dynamically adjusting the signal generation power, this technical solution can significantly improve the stability and reliability of the communication system and reduce data loss or delays caused by communication problems. This is particularly important for key application scenarios such as medical diagnosis, which can improve the accuracy and timeliness of medical services, thereby improving user experience and satisfaction. At the same time, the above technical solution can improve the coordination of the two units communicating with the control and analysis unit and the matching of communication transmission.

[0151] The design of this technical solution takes into account possible future expansion needs, and achieves independence and collaboration between different functions in a modular way. This allows the system to expand functions or optimize performance as needed in the future without making major changes to the entire system.

[0152] Working principle and use method of the present invention:

[0153] When in use, in the embodiment where the spiral 5 is fixedly connected to the injection terminal 4, the spiral 5 extends outward from the injection sleeve 1, and the extension distance is the same as the length of the injection needle 7. When injection is needed, it is only necessary to manually rotate the position of the injection terminal 4, and insert the spiral 5 connected to the injection needle 7 into the hypertrophic ventricular septum area to complete the local injection of anhydrous alcohol;

[0154] Embodiment where there is no connection between the spiral 5 and the injection tip 4

[0155] In the embodiment, the spiral 5 follows the injection catheter 3 to shrink into the injection sleeve 1. When injection is needed, the clamping tool 10 clamps the rotating column 10, and when the rotating column 10 is rotated, the rotating column 10 drives the injection catheter 3 to rotate, and synchronously drives the injection needle 7 at the front end of the injection catheter 3 to penetrate into the hypertrophic ventricular septum area. The syringe is inserted into the rotating column 10 to complete the injection. The present invention screws the injection needle 7 into the hypertrophic ventricular septum area through the superior vena cava, and injects anhydrous alcohol into the area through the injection needle 7. Due to the limitation of the injection area, it will not spread around, effectively controlling the hidden dangers of large trauma and complications, and having higher safety. The injection needle is screwed into the superior vena cava through the superior vena cava. The hypertrophic ventricular septum area is targeted, and anhydrous alcohol is injected into the area through the injection needle. The area is positioned through the electrocardiogram detection module, X-ray imaging detection, cardiac cavity ultrasound detection and electrode detection device to ensure that the area is exactly in the middle of the ventricular septum, thereby achieving dynamic and relatively accurate positioning of the puncture position, avoiding deviation from the position, and improving the effect of the injection. Anhydrous alcohol can cause local myocardial damage, thereby relieving outflow tract obstruction. At the same time, due to the limitation of the injection area, it will not spread around, so there will be no large-area myocardial damage, thus avoiding damage to the myocardial conduction system, and effectively controlling the hidden dangers of large trauma and complications, with higher safety and more obvious effects.

[0156] The above description is only used to illustrate the technical solution of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, it should be understood by those skilled in the art that the technical solution described in the aforementioned embodiments can still be modified, or some or all of the technical features therein can be replaced by equivalents. Any equivalent structure or equivalent process transformation made using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A hypertrophic obstructive cardiomyopathy treatment system, characterized in that: include: A mechanical injection device comprises an injection sleeve (1), wherein an injection catheter (3) is movably inserted into the injection sleeve (1), wherein the injection catheter (3) contains a contrast medium, wherein an injection needle (7) is mounted at one end of the injection catheter (3), wherein the injection catheter (3) is hollow and communicates with the injection needle (7), wherein a spiral (5) is sleeved on the outside of the injection needle (7), wherein the spiral (5) is fixed to the injection catheter (3), and further comprises a syringe for injecting anhydrous alcohol into the ventricular septum via the injection catheter (3) and the injection needle (7); The positioning detection device comprises: The cardiac cavity ultrasound detection unit obtains the ultrasound cardiograms of the local myocardium before and after the injection of anhydrous alcohol, and performs image processing on the ultrasound cardiograms of the local myocardium before and after the injection to obtain preliminary positioning area information, wherein the preliminary positioning area information includes the thickness and position of the local myocardium; An X-ray image detection unit, comprising an X-ray emitter, for scanning the ventricular septum after injection of anhydrous alcohol to obtain an X-ray contrast image, and obtaining injection position image information based on the X-ray contrast image, wherein the injection position image information includes current position information of the spiral (5) and current insertion depth of the injection needle (7); The injection sleeve (1) uses an electrode wire, including a cathode and an anode, and the positioning detection device also includes: A detection sensor, the detection sensor comprising an impedance sensor, a sensing sensor and a threshold sensor which are arranged at intervals on the outer wall of the injection sleeve (1) near one end of the spiral (5), the impedance sensor being used to detect the impedance value of the local myocardium, the sensing sensor being used to detect the voltage level of the local myocardium, and the threshold sensor being used to detect the minimum amplitude of the local current output to capture the myocardium; a control and analysis unit, electrically connected to the detection sensors respectively, for receiving the detected sensor parameter values, the sensor parameter values ​​including the impedance value of the local myocardium, the local myocardial voltage level and the minimum amplitude of the local current output to capture the myocardium, and comparing the sensor parameters with the sensor parameter thresholds; the control and analysis unit is also used to adjust the signal generation power of the impedance sensor, the perception sensor and the threshold sensor by real-time monitoring of the communication duration of the impedance sensor, the perception sensor and the threshold sensor; The output display unit includes a display screen, and is used to output and display the analysis result of the control and analysis unit through the display screen.

2. A hypertrophic obstructive cardiomyopathy treatment system according to claim 1, characterized in that: A limit baffle (2) is fixedly arranged inside the injection sleeve (1), a through hole is opened on the limit baffle (2), the injection catheter (3) passes through the through hole, and a fixed guide wire is movably arranged inside the injection catheter (3); an injection terminal (4) is arranged at one end of the injection sleeve (1) on the same side as the spiral (5), a sealing tube (8) is fixedly arranged at one end of the injection sleeve (1) away from the spiral (5), a sealing tube terminal (9) is arranged at the front end of the sealing tube (8), and the spiral (5) and the injection terminal (4) are fixedly connected or not connected.

3. A hypertrophic obstructive cardiomyopathy treatment system according to claim 2, characterized in that: When the spiral (5) is not connected to the injection end (4), the spiral (5) is retracted into the injection sleeve (1) in a non-working state, a rotating column (10) is inserted into the sealing tube end (9), the inner end of the rotating column (10) is fixedly connected to the injection catheter (3), the interior of the rotating column (10) is arranged in a hollow cavity, and also includes a clamping tool (11) for clamping the rotating column (10) for rotation, and the rotating column (10) drives the spiral (5) and the injection needle (7) to pass through the injection sleeve (1) to form an injection state.

4. A hypertrophic obstructive cardiomyopathy treatment system according to claim 2, characterized in that: When the spiral (5) is fixedly connected to the injection end (4), the spiral (5) extends outward from the injection end (4) for a distance that is the same as the length of the injection needle (7), and a screwing operation portion is formed on the outer peripheral surface of the injection end (4).

5. A hypertrophic obstructive cardiomyopathy treatment system according to claim 1, characterized in that: The control and analysis unit is also used to adjust the signal generation power of the impedance sensor, the perception sensor and the threshold sensor, including: A first real-time monitoring module, used for real-time monitoring of the signal sending time and signal receiving time corresponding to the signal sent by the impedance sensor to the control and analysis unit; A first communication duration acquisition module, used to acquire the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the impedance sensor to the control and analysis unit, and record the communication duration as the first communication duration; A second real-time monitoring module is used to monitor in real time the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit; A second communication duration acquisition module, used to obtain the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit, and record the communication duration corresponding to each signal obtained by the signal sending time and signal receiving time corresponding to the signal sent by the perception sensor to the control and analysis unit as the second communication duration; A third real-time monitoring module is used to monitor in real time the signal sending time and the signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit; A third communication duration acquisition module, used to obtain the communication duration corresponding to each signal by using the signal sending time and signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit, and record the communication duration corresponding to each signal obtained by the signal sending time and signal receiving time corresponding to the signal sent by the threshold sensor to the control and analysis unit as the third communication duration; The first communication duration parameter factor acquisition module is used to obtain the first communication duration parameter factor using the first communication duration, wherein the first communication duration parameter factor is obtained by the following formula: Among them, J 01 represents the first communication duration parameter factor; n represents the number of times the impedance sensor sends a signal to the control and analysis unit; G 01i represents the signal power corresponding to the signal sent by the i-th impedance sensor to the control and analysis unit; G fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 01i T represents the communication time corresponding to the signal sent by the i-th impedance sensor to the control and analysis unit; fmax Indicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; T max01 Indicates the maximum communication duration of the impedance sensor sending a signal to the control and analysis unit; G max01 Indicates the signal generation power of the impedance sensor corresponding to the maximum communication duration; The second communication duration parameter factor acquisition module is used to acquire a second communication duration parameter factor using the second communication duration, wherein the second communication duration parameter factor is acquired by the following formula: Among them, J 02 represents the second communication duration parameter factor; m represents the number of times the perception sensor sends a signal to the control and analysis unit; G 02i G represents the signal generation power corresponding to the signal sent by the i-th perception sensor to the control and analysis unit; fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 02i T represents the communication duration corresponding to the signal sent by the i-th perception sensor to the control and analysis unit; fmax Indicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; T max02 Indicates the maximum communication duration of the perception sensor sending signals to the control and analysis unit; G max02 Indicates the signal generation power of the perception sensor corresponding to the maximum communication duration; The third communication duration parameter factor acquisition module is used to obtain the third communication duration parameter factor using the third communication duration, and the third communication duration parameter factor is obtained by the following formula: Among them, J 03 represents the first communication duration parameter factor; q represents the number of times the threshold sensor sends a signal to the control and analysis unit; G 03i represents the signal power corresponding to the signal sent by the i-th threshold sensor to the control and analysis unit; G fmin Indicates the minimum permissible signal generation power required to meet the communication requirements between the control and analysis unit; T 03i T represents the communication duration corresponding to the signal sent by the threshold sensor to the control and analysis unit for the i-th time; fmax Indicates the maximum permissible communication time required to meet the communication requirements with the control and analysis unit; T max03 Indicates the maximum communication duration of the threshold sensor sending a signal to the control and analysis unit; G max03 Indicates the signal generation power of the threshold sensor corresponding to the maximum communication duration; The signal generation power adjustment module is used to monitor in real time the difference between the first communication duration parameter factor, the second communication duration parameter factor, the third communication duration factor and the standard duration parameter factor. When the difference exceeds a preset difference threshold, the signal generation power of the impedance sensor and / or the perception sensor and / or the threshold sensor is adjusted.

6. A hypertrophic obstructive cardiomyopathy treatment system according to claim 5, characterized in that: The signal generation power adjustment module comprises: A parameter factor quantity relationship determination module, used to respectively monitor in real time the difference between the first communication duration parameter factor, the second communication duration parameter factor, the third communication duration factor and the standard duration parameter factor, and when the difference exceeds a preset difference threshold, retrieve the corresponding first communication duration parameter factor and / or the second communication duration parameter factor and / or the third communication duration parameter factor; An adjustment target unit determination module is used to use the impedance sensor and / or perception sensor and / or threshold sensor corresponding to the retrieved corresponding first communication duration parameter factor and / or second communication duration parameter factor and / or third communication duration parameter factor as the adjustment target unit; A signal generation power extraction module is used to extract the current signal generation power corresponding to the adjustment target unit; A parameter factor retrieving module, used to retrieve the first communication duration parameter factor, the second communication duration parameter factor, or the third communication duration parameter factor corresponding to the adjustment target unit; The target signal generation power acquisition module is used to obtain the adjusted signal generation power by using the current signal generation power corresponding to the adjustment target unit in combination with the first communication duration parameter factor or the second communication duration parameter factor or the third communication duration parameter factor corresponding to the adjustment target unit; wherein the adjusted signal generation power is obtained by the following formula: Among them, J 0x represents the xth communication duration parameter factor, x is 1 / 2 / 3, J O Represents the standard duration parameter factor, G m Indicates the signal power after adjustment; G c Indicates the signal power value corresponding to the target unit before signal power adjustment; J 01 represents the first communication duration parameter factor; J 02 represents the second communication duration parameter factor; J 03 represents the third communication duration parameter factor; g represents the adjustment coefficient, and the adjustment coefficient is as follows: Among them, G fc Indicates the standard deviation of the signal power corresponding to the adjusted target unit; G f Indicates the maximum signal power floating value allowed to meet communication requirements; G x Indicates the signal power value corresponding to the non-adjustment target unit before the signal power adjustment; The power adjustment execution module is used to adjust the signal generation power corresponding to the adjustment target unit according to the adjusted signal generation power.

7. A hypertrophic obstructive cardiomyopathy treatment system according to claim 1, characterized in that: The X-ray image detection unit also includes: An image receiver is used to collect the fluorescence generated when the X-rays emitted by the X-ray emitter are irradiated on the contrast agent, and develop it with the help of a fluorescent screen to form an X-ray contrast image; An image enhancement module, used to improve the contrast and clarity of the X-ray angiography image by using image enhancement technology, so as to make the image of the spiral (5) and / or the injection needle (7) more obvious; An angle adjustment module for changing the angle of the X-ray source and the image receptor to observe the position and depth of the spiral and / or injection needle (7) from different directions to obtain a more comprehensive view; The marking and measuring module is used to measure the current position information of the spiral (5) and the insertion depth of the injection needle (7) on the X-ray angiography image using a ruler and a marking tool to form injection position image information.

8. A hypertrophic obstructive cardiomyopathy treatment system according to claim 1, characterized in that: It also includes an arterial pressure measuring unit, which is used to obtain the pressure difference of the left ventricular outflow tract before and after the injection of anhydrous alcohol, and obtain the pressure difference detection value. The arterial pressure measuring unit includes an invasive direct arterial pressure measurement module, and the invasive direct arterial pressure measurement module includes a blood pressure monitor and a catheter connected to the blood pressure monitor.

9. A hypertrophic obstructive cardiomyopathy treatment system according to claim 1, characterized in that: The cardiac cavity ultrasound detection unit comprises: A probe positioning module, comprising a probe, wherein the probe is delivered into the heart cavity through a peripheral vein and is aimed at a target myocardial area, and the probe emits a short-wave ultrasound beam; A real-time imaging module receives ultrasound waves reflected in the heart cavity and forms a real-time two-dimensional or three-dimensional echocardiogram through electrical signal processing; The image processing module obtains a two-dimensional or three-dimensional echocardiogram and measures myocardial parameter information based on the echocardiogram, wherein the myocardial parameter information includes the thickness and position of the myocardium.

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