An alkaline liquid automated processing apparatus and method for inductively coupled plasma mass spectrometry

Abstract

The application provides a kind of for inductively coupled plasma mass spectrometry alkaline liquid automation processing device and method, it is related to automation processing technical field.The inductively coupled plasma mass spectrometry alkaline liquid automation processing device of the described device is controlled and adjusted by intelligent control module to temperature control unit, acid-base adjusting unit and mixed uniform control unit in acid-base titration module, and the control and adjustment of liquid level detection unit in constant volume module by intelligent control module, realize the automation processing of alkaline liquid, can effectively improve the automation pretreatment efficiency and analysis efficiency of inductively coupled plasma mass spectrometry alkaline liquid, improve the accuracy and reliability of analysis result, can adapt to the rapid analysis demand of large-scale alkaline liquid sample.The alkaline liquid automation processing device of the application can be widely applied to the pretreatment of inductively coupled plasma mass spectrometry and inductively coupled plasma atomic emission spectrometry alkaline liquid.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of automation processing, in particular to an alkaline liquid automatic processing device and method for inductively coupled plasma mass spectrometry. BACKGROUND

[0002] As a high-sensitivity, low-detection-limit element analysis technology, inductively coupled plasma mass spectrometry is widely used in environmental monitoring, geological mineral exploration, food safety detection, biological and pharmaceutical research, and material science, providing key data support for scientific research and industrial production. However, alkaline solutions can corrode key components such as the sampling system, torch, and interface of the instrument, shorten the service life of the instrument, and cause the plasma to be unstable, affecting ionization efficiency and mass spectrometry signals, and reducing the accuracy and precision of the analysis results. Therefore, effective pretreatment of alkaline liquids is necessary.

[0003] In the existing inductively coupled plasma mass spectrometry analysis process for alkaline solutions, a step-by-step manual operation is usually used for pretreatment, including acid neutralization, acidification to adjust pH, addition of deionized water for dilution and constant volume, and then sampling analysis. However, this method is inefficient, time-consuming, and lacks systematization and continuity, which can introduce human errors, affect the consistency of the processing effect and the accuracy and repeatability of the analysis results, and limit the continuous processing and analysis of large-scale samples.

[0004] Therefore, it is necessary and urgent to develop an efficient, accurate, and automated alkaline liquid pretreatment method and device for inductively coupled plasma mass spectrometry to overcome the shortcomings of the prior art and improve the efficiency and accuracy of inductively coupled plasma mass spectrometry analysis of alkaline liquids.

[0005] Therefore, the present application is proposed. SUMMARY

[0006] The present application aims to provide an alkaline liquid automatic processing device for inductively coupled plasma mass spectrometry to overcome the shortcomings of the prior art. The device can effectively improve the efficiency of automatic pretreatment and analysis of alkaline liquids by inductively coupled plasma mass spectrometry, save manpower and time, effectively reduce human errors, improve the accuracy and reliability of the analysis results, and meet the rapid analysis needs of large-scale alkaline liquid samples.

[0007] In order to achieve the above-mentioned purposes of the present application, the following technical solutions are adopted:

[0008] On the one hand, the present application provides an alkaline liquid automatic processing device for inductively coupled plasma mass spectrometry, which comprises an acid-base titration module, a constant volume module, and an intelligent control module.

[0009] The acid-base titration module comprises a volumetric flask, a temperature control unit, an acid-base adjusting unit and a mixing control unit, wherein:

[0010] The volumetric flask is used to hold the alkaline liquid;

[0011] The temperature control unit comprises a temperature sensor and a temperature regulator, and the volumetric flask is fixedly arranged in the temperature regulator; the intelligent control module is connected with the temperature sensor and the temperature regulator respectively, and the intelligent control module controls the temperature regulator through the temperature value fed back by the temperature sensor to realize the temperature adjustment of the liquid in the volumetric flask;

[0012] The acid-base adjusting unit comprises a metering pump, an electric valve and a pH sensor; the intelligent control module is connected with the metering pump, the electric valve and the pH sensor respectively, and the intelligent control module adjusts the metering pump and the electric valve through the pH value fed back by the pH sensor to realize the acid-base titration of the liquid in the volumetric flask;

[0013] The mixing control unit comprises a gas inlet pipeline; the intelligent control module adjusts the mixing control unit to control the gas in the gas inlet pipeline to enter the volumetric flask through the stability of the pH value fed back by the pH sensor, so as to realize the mixing of the liquid in the volumetric flask;

[0014] The constant volume module comprises a fixing box for placing the volumetric flask and a liquid level detection unit, wherein:

[0015] The fixing box is made of transparent material; the liquid level detection unit comprises a displacement platform and a monitoring camera arranged on the displacement platform; the intelligent control module is connected with the displacement platform and the monitoring camera respectively, the intelligent control module controls the vertical and horizontal displacement of the displacement platform so that the photosensitive center point of the monitoring camera and the scale line of the volumetric flask are kept on the same horizontal line; the intelligent control module feeds back the liquid level information of the volumetric flask through the monitoring camera to monitor the relationship between the scale line of the volumetric flask and the liquid level position in the volumetric flask in real time;

[0016] The intelligent control module controls the metering pump and the electric valve to adjust the liquid addition amount of acid-base titration through the relationship between the scale line of the volumetric flask and the liquid level position in the volumetric flask.

[0017] It should be noted that the alkaline liquid automatic processing device for inductively coupled plasma mass spectrometry provided by the present application controls and adjusts the acid-base titration module and the constant volume module through the intelligent control module, realizes the automatic processing of the alkaline liquid for inductively coupled plasma mass spectrometry, and specifically as follows:

[0018] 1. The intelligent control module of the application is connected with the metering pump, the electric valve and the pH sensor respectively, the intelligent control module adjusts the metering pump and the electric valve through the pH value fed back by the pH sensor, and realizes liquid titration;

[0019] 2. The intelligent control module of the application is connected with the temperature sensor and the temperature regulator respectively, the intelligent control module controls the temperature regulator to adjust the temperature of the liquid in the volumetric flask through the temperature value fed back by the temperature sensor;

[0020] 3. The intelligent control module of the application is connected with the displacement platform and the monitoring camera respectively, the intelligent control module makes the monitoring camera keep the same horizontal line with the scale line of the volumetric flask by controlling the movement of the displacement platform; the intelligent control module adjusts the liquid titration amount of acid-base titration through the liquid level information of the volumetric flask fed back by the monitoring camera;

[0021] 4. The intelligent control module of the application adjusts the gas inlet capacity bottle of the gas inlet pipeline of the mixing control unit through the stability of the pH value fed back by the pH sensor, and realizes the mixing of the liquid in the volumetric flask.

[0022] Therefore, the alkaline liquid automatic processing device for inductively coupled plasma mass spectrometry can effectively improve the automatic pretreatment efficiency and analysis efficiency of inductively coupled plasma mass spectrometry analysis of alkaline liquid, save manpower and time, reduce human error, improve the accuracy and reliability of the analysis results, can adapt to the rapid analysis demand of large-scale alkaline liquid samples, and can be further expanded to online inductively coupled plasma mass spectrometry and inductively coupled plasma atomic emission spectrometry analysis of alkaline liquid samples.

[0023] Further, the temperature regulator has the functions of cooling and heating.

[0024] Further, the temperature regulator includes any one of a semiconductor refrigeration sheet and a Peltier element.

[0025] Further, the liquid of the device includes: a to-be-tested alkaline liquid, an acidic liquid and a weakly acidic constant-volume liquid. The to-be-tested alkaline liquid and the acidic liquid are used to adjust the pH value in the acid-base titration process, and the weakly acidic constant-volume liquid is used for the constant-volume process.

[0026] Further, the gas in the gas inlet pipeline includes at least one of argon, helium and nitrogen.

[0027] Further, the displacement platform includes at least one of a one-dimensional displacement platform, a two-dimensional displacement platform or a three-dimensional displacement platform.

[0028] In another aspect, the application provides an automatic processing method for alkaline liquid for inductively coupled plasma mass spectrometry, which is based on the automatic processing device for alkaline liquid for inductively coupled plasma mass spectrometry.

[0029] In another aspect, the application provides the automatic processing device for alkaline liquid for inductively coupled plasma mass spectrometry or the automatic processing method for alkaline liquid for inductively coupled plasma mass spectrometry, which can be widely applied to the alkaline liquid pretreatment process of inductively coupled plasma mass spectrometry and inductively coupled plasma atomic emission spectrometry.

[0030] Compared with the prior art, the application has the following beneficial effects:

[0031] The application provides an automatic processing device for alkaline liquid for inductively coupled plasma mass spectrometry, which realizes the automatic processing of alkaline liquid for inductively coupled plasma mass spectrometry by controlling and adjusting the temperature control unit, the acid-base adjusting unit and the mixing control unit in the acid-base titration module and the liquid level detection unit in the constant volume module through the intelligent control module, can effectively improve the automatic pretreatment efficiency and analysis efficiency of alkaline liquid for inductively coupled plasma mass spectrometry, save manpower and time, reduce human error, improve the accuracy and reliability of the analysis results, can adapt to the rapid analysis requirements of large-scale alkaline liquid samples, and can be further expanded to online inductively coupled plasma mass spectrometry and inductively coupled plasma atomic emission spectrometry analysis of alkaline liquid samples. BRIEF DESCRIPTION OF DRAWINGS

[0032] In order to more clearly illustrate the technical solutions in the specific embodiments or the prior art, the drawings needed in the specific embodiments or the prior art description will be briefly introduced below. Obviously, the drawings in the following description are some embodiments of the application, and those skilled in the art can also obtain other drawings according to these drawings without creative labor.

[0033] Figure 1 The overall structure schematic diagram of the automatic processing device for alkaline liquid for inductively coupled plasma mass spectrometry provided by the application is shown in the figure.

[0034] Figure 2 The structure schematic diagram of the acid-base titration module and the constant volume module in the automatic processing device for alkaline liquid for inductively coupled plasma mass spectrometry provided by the application is shown in the figure.

[0035] Icons: 1-acid-base titration module; 2-constant volume module; 3-intelligent control module; 11-volume flask; 12-temperature control unit; 13-acid-base adjustment unit; 14-mixing control unit; 141-gas inlet pipeline; 21-fixed box; 22-liquid level detection unit; 121-temperature sensor; 122-temperature regulator; 131-metering pump; 132-electric valve; 133-pH sensor; 221-displacement platform; 222-monitoring camera. DETAILED DESCRIPTION

[0036] The following will clearly and completely describe the technical solutions of the present invention in conjunction with the embodiments. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0037] The technical solution of the present invention will be further described below with reference to embodiments.

[0038] Example 1

[0039] Figure 1 This is a schematic diagram of the overall structure of the automated alkaline liquid processing device for inductively coupled plasma mass spectrometry provided in this embodiment. Figure 1 The curves in are the connection lines between the intelligent control module 3 and each device.

[0040] Figure 2 This is a schematic structural diagram of the acid-base titration module 1 and the constant volume module 2 in the alkaline liquid automatic processing device for inductively coupled plasma mass spectrometry provided in this embodiment.

[0041] Depend on Figure 1 、 Figure 2 It can be seen that this embodiment provides an automated alkaline liquid processing device for inductively coupled plasma mass spectrometry, which includes: an acid-base titration module 1, a constant volume module 2 and an intelligent control module 3;

[0042] The acid-base titration module 1 includes a volumetric flask 11, a temperature control unit 12, an acid-base adjustment unit 13 and a mixing control unit 14, wherein:

[0043] The volumetric flask 11 is used to hold an alkaline liquid; the temperature control unit 12 includes a temperature sensor 121 and a temperature regulator 122, which are used to monitor and adjust the temperature of the liquid in the volumetric flask 11 in real time. The volumetric flask 11 is fixedly arranged in the temperature regulator 122; the intelligent control module 3 is connected to the temperature sensor 121 and the temperature regulator 122 respectively, and the intelligent control module 3 controls the temperature regulator 122 through the temperature value fed back by the temperature sensor 121 to achieve temperature regulation of the liquid in the volumetric flask 11;

[0044] In a preferred embodiment of the present application, the temperature regulator 122 has the functions of temperature reduction and temperature increase.

[0045] In the preferred embodiment described above, the temperature regulator 122 comprises any one of a semiconductor refrigeration sheet and a Peltier element.

[0046] It should be noted that the intelligent control module 3 controls the temperature regulator 122 according to the temperature value fed back by the temperature sensor 121, thereby realizing the automatic processing of the temperature of the liquid in the volumetric flask 11. For example, a temperature value for acid-base titration is set in the intelligent control module 3, if the temperature value fed back by the temperature sensor 121 is greater than the temperature value, the temperature regulator 122 is adjusted to reduce the temperature of the liquid in the volumetric flask 11, and if the temperature value fed back by the temperature sensor 121 is less than the temperature value, the temperature regulator 122 is adjusted to increase the temperature of the liquid in the volumetric flask 11.

[0047] The mixing control unit 14 comprises a gas inlet pipeline 141, and the intelligent control module 3 adjusts the gas inlet capacity of the gas inlet pipeline 141 of the mixing control unit 14 according to the stability of the pH value fed back by the pH sensor 133, so as to realize the mixing of the liquid in the volumetric flask 11.

[0048] It should be noted that the intelligent control module 3 adjusts the gas inlet of the gas inlet pipeline 141 in the mixing control unit 14 according to the stability of the pH value fed back by the pH sensor 133, so as to realize the automatic mixing of the liquid in the volumetric flask 11. For example, the pH value set in the intelligent control module 3 is 0.1-0.8, and the mixing control unit 14 uses the gas inlet pipeline 141 to realize the mixing of the liquid in the volumetric flask 11 until the pH value is stable at the required acidity (pH=0.1-0.8) of the instrument.

[0049] In a preferred embodiment of the present application, the gas introduced into the gas inlet pipeline 141 comprises at least one of argon, helium and nitrogen.

[0050] The acid-base adjusting unit 13 comprises a metering pump 131, an electric valve 132 and a pH sensor 133, the intelligent control module 3 is connected with the metering pump 131, the electric valve 132 and the pH sensor 133, and the intelligent control module 3 adjusts the metering pump 131 and the electric valve 132 according to the pH value fed back by the pH sensor 133, thereby realizing the acid-base titration of the liquid in the volumetric flask 11.

[0051] In a preferred embodiment of the present embodiment, the liquid used for the above-mentioned acid-base titration includes: a basic liquid to be tested, an acidic liquid, and a weakly acidic constant-volume liquid. The basic liquid to be tested and the acidic liquid are used to adjust the pH value in the acid-base titration process, and the weakly acidic constant-volume liquid is used for constant volume in the acid-base titration process.

[0052] In the above-mentioned preferred embodiment, the acid-base adjusting unit 13 of the present embodiment further includes a four-way pipe in communication with the pipelines conveying the basic liquid to be tested, the acidic liquid, and the weakly acidic constant-volume liquid. The four-way pipe is provided with a metering pump 131 and an electric valve 132 on each pipeline in communication with the four-way pipe. The metering pump 131 and the electric valve 132 on each pipeline are connected with the intelligent control module 3 to realize titration control of different acid-base titration liquids.

[0053] It should be noted that the intelligent control module 3 adjusts the metering pump 131 and the electric valve 132 to realize acid-base titration of the liquid in the volumetric flask 11 through the pH value fed back by the pH sensor 133. That is, the pH of the solution in the acid-base titration process is monitored in real time through the pH sensor 133, and the amount of the acidic liquid added is adjusted accordingly. The amount of the acidic liquid can be measured by the precision metering pump 131, and the flow of the acidic liquid can be controlled by the electric valve 132. For example, a pH value or a pH range value for acid-base titration is set in the intelligent control module 3. If the pH value fed back by the pH sensor 133 is greater than or less than the value, the addition of the acid-base titration liquid is adjusted through the metering pump 131 and the electric valve 132, thereby realizing automatic control of the pH value of the acid-base titration.

[0054] The constant-volume module 2 includes a fixing box 21 for placing the volumetric flask 11 and a liquid level detection unit 22.

[0055] The fixing box 21 is made of transparent material. The liquid level detection unit 22 includes a displacement platform 221 and a monitoring camera 222 arranged on the displacement platform 221. The intelligent control module 3 is connected with the displacement platform 221 and the monitoring camera 222, respectively. The intelligent control module 3 controls the vertical and horizontal displacement of the displacement platform 221 so that the photosensitive center point of the monitoring camera 222 is kept on the same horizontal line as the scale line of the volumetric flask 11. The intelligent control module 3 feeds back the liquid level information of the volumetric flask 11 through the monitoring camera 222 to monitor the relationship between the scale line of the volumetric flask 11 and the liquid level position in the volumetric flask 11 in real time.

[0056] The intelligent control module 3 controls the metering pump 131 and the electric valve 132 of the acid-base adjusting unit 13 to adjust the amount of acid-base titration through the relationship between the scale line of the volumetric flask 11 and the liquid level position in the volumetric flask 11.

[0057] It should be noted that, in the process of constant volume, the intelligent control module 3 of the present application monitors the liquid level information of the liquid surface of the volumetric flask 11 based on the monitoring camera 222, adjusts the addition of the constant volume liquid by real-time observation of the relative distance between the constant volume scale and the concave liquid surface of the solution, and the amount of liquid is measured by the precision metering pump 131, and the flow of the liquid is controlled by the electric valve 132.

[0058] In a preferred embodiment of the present embodiment, the displacement platform 221 comprises one of a one-dimensional displacement platform 221, a two-dimensional displacement platform 221 or a three-dimensional displacement platform 221.

[0059] It should be noted that the monitoring camera 222 and the scale line of the volumetric flask 11 are kept on the same horizontal line. When the constant volume of the volumetric flask 11 is adjusted, the monitoring camera 222 changes with the change of the height of the scale line (1mL-2000mL) of the volumetric flask 11 through the movement of the displacement platform 221.

[0060] The alkaline liquid automatic processing device for inductively coupled plasma mass spectrometry provided by the present embodiment is used for automatically processing alkaline liquid, and the method comprises:

[0061] S1: The alkaline liquid to be processed is placed in the volumetric flask 11 of the alkaline liquid automatic processing device, and then the device is started. The intelligent control module 3 receives feedback to obtain the following information:

[0062] 1. The temperature value fed back by the temperature sensor 121;

[0063] 2. The pH value fed back by the pH sensor 133;

[0064] 3. The liquid level information of the volumetric flask 11 fed back by the monitoring camera 222;

[0065] S2: Based on the information fed back in step S1, the intelligent control module 3 automatically processes the acid-base titration process of the alkaline liquid, specifically as follows:

[0066] The intelligent control module 3 controls the temperature regulator 122 through the temperature value fed back by the temperature sensor 121 to realize the temperature adjustment of the liquid in the volumetric flask 11;

[0067] The intelligent control module 3 adjusts the metering pump 131 and the electric valve 132 through the pH value fed back by the pH sensor 133 to adjust the amount of the added acidic liquid; wherein the amount of the acidic liquid can be measured by the precision metering pump 131 during the titration process, and the flow of the acidic liquid can be controlled by the electric valve 132; at the same time, the gas inlet of the gas inlet pipeline 141 in the mixing control unit 14 is adjusted through the stability of the pH value fed back by the pH sensor 133 to realize the automatic mixing processing of the liquid in the volumetric flask 11.

[0068] The intelligent control module 3 obtains the relationship between the scale line of the volumetric flask 11 and the liquid level position in the volumetric flask 11 by monitoring the liquid level information of the volumetric flask 11 fed back by the camera 222, and then controls the metering pump 131 and the electric valve 132 of the acid-base adjusting unit 13 to perform constant volume adjustment on the amount of acid-base titration.

[0069] Therefore, the alkaline liquid automatic processing device for inductively coupled plasma mass spectrometry can automatically process the monitoring information through the intelligent control module 3, finally realize the automatic pretreatment of the alkaline liquid, meet the sample injection requirements, effectively improve the automatic pretreatment efficiency and analysis efficiency of the alkaline liquid analyzed by the inductively coupled plasma mass spectrometry, save manpower and time, reduce human errors, and improve the accuracy and reliability of the analysis results.

[0070] Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present application, and not to limit them; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement for part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. An automated alkaline liquid processing device for inductively coupled plasma mass spectrometry, characterized in that: The device comprises: an acid-base titration module (1), a volume determination module (2) and an intelligent control module (3); The acid-base titration module (1) comprises a volumetric flask (11), a temperature control unit (12), an acid-base adjustment unit (13) and a mixing control unit (14), wherein: The volumetric flask (11) is used to hold alkaline liquid; the temperature control unit (12) comprises a temperature sensor (121) and a temperature regulator (122), and the volumetric flask (11) is fixedly arranged in the temperature regulator (122); the intelligent control module (3) is connected to the temperature sensor (121) and the temperature regulator (122) respectively, and the intelligent control module (3) controls the temperature regulator (122) according to the temperature value fed back by the temperature sensor (121), thereby achieving temperature regulation of the liquid in the volumetric flask (11); The acid-base adjustment unit (13) comprises a metering pump (131), an electric valve (132) and a pH sensor (133); the intelligent control module (3) is connected to the metering pump (131), the electric valve (132) and the pH sensor (133) respectively, and the intelligent control module (3) adjusts the metering pump (131) and the electric valve (132) according to the pH value fed back by the pH sensor (133) to achieve acid-base titration of the liquid in the volumetric flask (11); The mixing control unit (14) includes a gas inlet pipeline (141); the intelligent control module (3) adjusts the mixing control unit (14) to control the gas in the gas inlet pipeline (141) to be passed into the volumetric flask (11) based on the stability of the pH value fed back by the pH sensor (133), thereby achieving mixing of the liquid in the volumetric flask (11); The volume control module (2) comprises a fixing box (21) for placing the volumetric flask (11) and a liquid level detection unit (22), wherein: The fixed box (21) is made of a transparent material; the liquid level detection unit (22) includes a displacement platform (221) and a monitoring camera (222) arranged on the displacement platform (221); the intelligent control module (3) is connected to the displacement platform (221) and the monitoring camera (222) respectively, and the intelligent control module (3) controls the vertical and horizontal displacements of the displacement platform (221) so that the photosensitive center point of the monitoring camera (222) and the scale line of the volumetric flask (11) are kept at the same horizontal line; the intelligent control module (3) feeds back the liquid level information of the volumetric flask (11) through the monitoring camera (222) and monitors the relationship between the scale line of the volumetric flask (11) and the liquid level position in the volumetric flask (11) in real time; The intelligent control module (3) controls the metering pump (131) and the electric valve (132) to adjust the amount of liquid added for acid-base titration based on the relationship between the scale line of the volumetric flask (11) and the position of the liquid level in the volumetric flask (11).

2. The automatic alkaline liquid processing device for inductively coupled plasma mass spectrometry according to claim 1, characterized in that: The temperature regulator (122) has the functions of cooling and heating.

3. The automatic alkaline liquid processing device for inductively coupled plasma mass spectrometry according to claim 1, characterized in that: The temperature regulator (122) includes any one of a semiconductor refrigeration plate and a Peltier element.

4. The automatic alkaline liquid processing device for inductively coupled plasma mass spectrometry according to claim 1, characterized in that: The gas introduced into the gas inlet pipeline (141) includes at least one of argon, helium and nitrogen.

5. The automatic alkaline liquid processing device for inductively coupled plasma mass spectrometry according to claim 1, characterized in that: The displacement platform (221) includes at least one of a one-dimensional displacement platform, a two-dimensional displacement platform, or a three-dimensional displacement platform.

6. A method for automated processing of alkaline liquids for inductively coupled plasma mass spectrometry, characterized in that: The method is implemented based on the automatic alkaline liquid processing device for inductively coupled plasma mass spectrometry according to any one of claims 1 to 5.

7. Use of the automated alkaline liquid treatment device for inductively coupled plasma mass spectrometry according to any one of claims 1 to 5 or the automated alkaline liquid treatment method for inductively coupled plasma mass spectrometry according to claim 6 in the treatment of alkaline liquids for inductively coupled plasma mass spectrometry and inductively coupled plasma atomic emission spectrometry.

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