Supramolecular carnosine composition with SMAPPT peptide for moisturizing, preparation and application

Abstract

The present invention belongs to the technical field of skin care products, and discloses a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide and its preparation and application. The preparation method is as follows: MA, cyclodextrin raw material and cyclic siloxane are added to DMF solvent, heated, catalytically stirred and reacted to obtain maleic acid-modified cyclodextrin / hydroxypolysiloxane complex; the obtained complex is added to an ethanol aqueous solution, stirred and dissolved evenly, and then the carnosine raw material is added and stirred and dissolved evenly. The obtained mixed solution is spray-dried under vacuum to make powder to obtain carnosine microcapsules coated with modified cyclodextrin complex; then the carnosine microcapsules coated with modified cyclodextrin complex are homogenized and emulsified evenly with an emulsifier, a thickener, a humectant and water to obtain a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide. The present invention uses maleic acid-modified cyclodextrin / hydroxypolysiloxane complex to coat the carnosine raw material, so that its anti-aging repair and synergistic moisturizing effects can be better exerted.

Description

Technical Field

[0001] The present invention belongs to the technical field of skin care products, and particularly relates to a supramolecular carnosine composition with a water replenishing effect of SMAPPT peptide and its preparation and application. Background Art

[0002] Carnosine has antioxidant properties and is a natural antioxidant. The use of carnosine in cosmetics can prevent skin aging and has the effect of whitening the skin. However, there are few reports on the effects of carnosine in synergistically repairing the skin barrier, promoting skin penetration and absorption, improving the skin's water-locking ability, and enhancing the water replenishing ability of the composition.

[0003] Due to the antioxidant properties of carnosine, it is prone to risks of oxidation discoloration and reduced activity under conditions such as high temperature and light in cosmetic formulations. Therefore, solving the stability of carnosine in cosmetic formulations is the key to its application.

[0004] CN 114306113 B discloses a composition containing supramolecular carnosine, and the supramolecular carnosine is formed by hydrogen bonding of one or two of acetyl carnosine, decarboxylated carnosine hydrochloride, and carnosine; the supramolecular carnosine synthesized by the supramolecular interaction between the structures of carnosine derivatives has an anti-glycation function; by combining with a protective agent and excipients, its stability is improved. However, the protective agents used are mainly reducing agents such as vitamin C glucoside, sodium metabisulfite, and purslane extract, which mainly act as sacrificial agents and cannot effectively protect carnosine molecules specifically. Especially in different formulation systems, the stability of carnosine cannot be effectively guaranteed.

[0005] Supramolecules generally refer to aggregates composed of two or more molecules bound together by intermolecular interactions (such as hydrogen bonds, van der Waals forces, Coulomb interactions of charges, π-π conjugation, etc.), which are complex and organized. However, there are few reports on improving the stability of carnosine compositions and synergistically enhancing the water replenishing, water-locking, and repair effects through supramolecular interactions. Summary of the Invention

[0006] Aiming at the above-mentioned drawbacks and deficiencies of the prior art, the primary object of the present invention is to provide a preparation method of a supramolecular carnosine composition with a water replenishing effect of SMAPPT peptide.

[0007] Another object of the present invention is to provide a supramolecular carnosine composition with a water replenishing effect of SMAPPT peptide prepared by the above method.

[0008] Another object of the present invention is to provide the application of the above supramolecular carnosine composition with a water replenishing effect of SMAPPT peptide in skin care products such as essence, skin cream, and facial mask.

[0009] The object of the present invention is achieved by the following technical solutions:

[0010] A preparation method of a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide, comprising the following preparation steps:

[0011] (1) Maleic anhydride (MA), cyclodextrin raw material and cyclosiloxane are added to N,N-dimethylformamide (DMF) solvent, heated to 90-120 °C and stirred until dissolved evenly, then an acidic catalyst is added and stirred for reaction. After the reaction is completed, the solvent and unreacted raw materials are removed by reduced pressure evaporation to obtain maleic acid-modified cyclodextrin / hydroxypolysiloxane complex;

[0012] (2) The maleic acid-modified cyclodextrin / hydroxypolysiloxane complex obtained in step (1) is added to an ethanol aqueous solution and stirred until dissolved evenly, then carnosine raw material is added and stirred until dissolved evenly. The obtained mixed solution is spray-dried under vacuum to obtain carnosine microcapsules coated with modified cyclodextrin complex;

[0013] (3) The carnosine microcapsules coated with modified cyclodextrin complex obtained in step (2) are homogenized and emulsified evenly with an emulsifier, a thickener, a humectant and water to obtain a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide.

[0014] Preferably, the cyclodextrin raw material in step (1) is β-cyclodextrin (β-CD) or hydroxypropyl-β-cyclodextrin (HP-β-CD).

[0015] Preferably, the cyclosiloxane in step (1) is tetramethyltetrahydrocyclotetrasiloxane (D4H) or octamethylcyclotetrasiloxane (D4).

[0016] Preferably, the addition amount of maleic anhydride in step (1) is 10%-60% of the mass of the cyclodextrin raw material, and the addition amount of the cyclosiloxane is 10%-40% of the mass of the cyclodextrin raw material.

[0017] Preferably, the acidic catalyst in step (1) is butylsulfonic acid, β-butylsulfonic acid-cyclodextrin or p-toluenesulfonic acid; the addition amount of the acidic catalyst is 0.1%-0.5% of the mass of the cyclodextrin raw material.

[0018] Preferably, the stirring reaction time in step (1) is 2-6 h.

[0019] Preferably, the ethanol aqueous solution in step (2) refers to an ethanol aqueous solution with an ethanol mass fraction of 50%-80%.

[0020] Preferably, the carnosine raw material in step (2) is at least one of acetyl carnosine, decarboxylated carnosine, and carnosine; the addition amount of the carnosine raw material is 5%-30% of the mass of the maleic acid-modified cyclodextrin / hydroxypolysiloxane complex.

[0021] Preferably, the temperature for stirring and dissolving in step (2) does not exceed 80°C, and the temperature for vacuum spray drying does not exceed 100°C.

[0022] Preferably, the emulsifier in step (3) is hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer (EMT-10); the thickener is carbomer; the humectant is at least one of hyaluronic acid (HA), amino acid humectant, glycerol polyether-26 (EG-1), and triethanolamine (TEA).

[0023] Preferably, the mass percentage ratios of the components in step (3) are as follows:

[0024] Modified cyclodextrin complex-coated carnosine microcapsules 0.5% - 5%, emulsifier 0.02% - 0.1%, thickener 0.05% - 0.3%, humectant 4% - 12%, and the balance is water.

[0025] A supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide is prepared by the above method.

[0026] The application of the above supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide in skin care products such as essence, skin cream, and facial mask.

[0027] The principle of the present invention is as follows: Cyclodextrin inclusion complexes have the function of protecting active ingredient components, preventing the active ingredient components from being oxidized or decomposed by light and heat, and improving the stability of the active ingredient components in the formulation; at the same time, cyclodextrin has a film-forming effect, which can synergistically improve the water replenishing and water locking abilities of the moisturizing components. However, unmodified cyclodextrin has strong water solubility, and its coating stability for active ingredient raw materials such as carnosine in aqueous formulations and its improvement effect on the water replenishing and water locking abilities of the moisturizing components are limited. In the present invention, maleic anhydride is used to carry out monoesterification graft modification and diesterification crosslinking modification on cyclodextrin raw materials under the condition of an acidic catalyst; at the same time, cyclic siloxane undergoes a ring-opening reaction under the condition of an acidic catalyst to obtain a hydroxy polysiloxane component. The hydroxy polysiloxane and the esterified modified cyclodextrin form an interpenetrating network composite structure, and at the same time, the monoesterification graft-modified cyclodextrin contains a large number of carboxyl groups that form a supramolecular composite structure with the hydroxy polysiloxane through hydrogen bonds, and the hydrophobicity and low surface tension characteristics of polysiloxane are used to reduce the water solubility of cyclodextrin and improve its film-forming effect. In addition, the diesterification crosslinked modified cyclodextrin can also reduce the water solubility of cyclodextrin due to its crosslinking gel effect. At the same time, the formed crosslinked network can, on the one hand, improve the composite effect with the hydroxy polysiloxane, and on the other hand, contribute to the stable coating of the subsequent carnosine raw materials. Finally, the large number of hydroxyl groups and carboxyl groups contained in the modified cyclodextrin complex can also form a supramolecular composite structure with the carnosine raw materials through hydrogen bonds, thereby improving the stability and synergistic application effect of the carnosine component in the composition.

[0028] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0029] (1) The present invention uses a maleic acid-modified cyclodextrin / hydroxypolysiloxane complex to coat the carnosine raw material, which can improve the stability of the carnosine raw material in the formula and better exert its anti-aging, repair and synergistic moisturizing effects.

[0030] (2) Through the synergistic effect of the modified cyclodextrin complex-coated carnosine microcapsules and the humectant in the supramolecular carnosine composition of the present invention, it can promote the skin's absorption of moisture and improve the water replenishment effect; at the same time, it can achieve a more excellent film-forming effect and water-locking effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 and Figure 2 are the test comparison charts of the water replenishment effect and water-locking effect of the composition obtained in Example 1 of the present invention and the compositions of Comparative Examples 1 and 2.

[0032] Figure 3 are the test result charts of the repair and anti-aging effects of the compositions obtained in Examples 1-4 of the present invention and the compositions of Comparative Examples 1-2. DETAILED DESCRIPTION OF THE INVENTION

[0033] The present invention will be further described in detail below in conjunction with the examples and the drawings, but the implementation manners of the present invention are not limited thereto.

[0034] Example 1

[0035] A preparation method of a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide, comprising the following preparation steps:

[0036] (1) MA, HP-β-CD and D4 were added to the DMF solvent according to a mass ratio of 30:100:20, heated to 105 °C and stirred until dissolved uniformly, then a butylsulfonic acid catalyst relative to 2‰ of the mass of HP-β-CD was added and stirred for 4 h. After the reaction was completed, the solvent and unreacted raw materials were removed by vacuum distillation at 120 °C to obtain a maleic acid-modified cyclodextrin / hydroxypolysiloxane complex.

[0037] (2) The maleic acid-modified cyclodextrin / hydroxypolysiloxane complex obtained in step (1) was added to a 75% ethanol aqueous solution at 70 °C and stirred until dissolved uniformly, then 20% of the mass of the complex of acetyl carnosine was added and stirred until dissolved uniformly. The obtained mixed solution was spray-dried into powder under vacuum at 90 °C to obtain modified cyclodextrin complex-coated carnosine microcapsules.

[0038] (3) By mass percentage, 2% of the modified cyclodextrin complex-coated carnosine microcapsules are homogenously emulsified with 0.05% of EMT-10, 0.15% of carbomer 940, 0.02% of HA (with a molecular weight of 1.3 million), 3% of amino acid humectant (betaine), 5% of EG-1, 0.3% of TEA, and the balance of water to obtain a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide.

[0039] Example 2

[0040] A preparation method of a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide, comprising the following preparation steps:

[0041] (1) MA, HP-β-CD, and D4 are added to a DMF solvent at a mass ratio of 10:100:10, heated to 90 °C and stirred until dissolved evenly, then a butylsulfonic acid catalyst relative to 4‰ of the mass of HP-β-CD is added and stirred for reaction for 6 h. After the reaction is completed, the solvent and unreacted raw materials are removed by distillation under reduced pressure at 120 °C to obtain a maleic acid-modified cyclodextrin / hydroxypolysiloxane complex.

[0042] (2) The maleic acid-modified cyclodextrin / hydroxypolysiloxane complex obtained in step (1) is added to a 60% aqueous ethanol solution at 80 °C and stirred until dissolved evenly, then 30% of the mass of the complex of acetyl carnosine is added and stirred until dissolved evenly. The obtained mixed solution is spray-dried into powder under vacuum at 90 °C to obtain modified cyclodextrin complex-coated carnosine microcapsules.

[0043] (3) By mass percentage, 1% of the modified cyclodextrin complex-coated carnosine microcapsules are homogenously emulsified with 0.02% of EMT-10, 0.2% of carbomer 940, 0.03% of HA (with a molecular weight of 1.3 million), 4% of amino acid humectant (betaine), 6% of EG-1, 0.4% of TEA, and the balance of water to obtain a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide.

[0044] Example 3

[0045] A preparation method of a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide, comprising the following preparation steps:

[0046] (1) MA, HP-β-CD, and D4 are added to a DMF solvent at a mass ratio of 60:100:40, heated to 110 °C and stirred until dissolved evenly, then a butylsulfonic acid catalyst relative to 5‰ of the mass of HP-β-CD is added and stirred for reaction for 6 h. After the reaction is completed, the solvent and unreacted raw materials are removed by distillation under reduced pressure at 120 °C to obtain a maleic acid-modified cyclodextrin / hydroxypolysiloxane complex.

[0047] (2) The maleic acid-modified cyclodextrin / hydroxypolysiloxane complex obtained in step (1) was added to an 80% ethanol aqueous solution at 60 °C and stirred until dissolved uniformly. Then, carnosine acetylated at 5% of the mass of the complex was added and stirred until dissolved uniformly. The resulting mixture was spray-dried under vacuum at 95 °C to obtain microcapsules of carnosine coated with the modified cyclodextrin complex.

[0048] (3) By mass percentage, 4% of the microcapsules of carnosine coated with the modified cyclodextrin complex, 0.08% of EMT-10, 0.05% of carbomer 940, 0.01% of HA (molecular weight of 1.3 million), 2% of amino acid humectant (betaine), 3% of EG-1, 0.2% of TEA, and the balance of water were homogenized and emulsified uniformly to obtain a supramolecular carnosine composition with a water replenishing effect of SMAPPT peptide.

[0049] Example 4

[0050] A preparation method of a supramolecular carnosine composition with a water replenishing effect of SMAPPT peptide, comprising the following preparation steps:

[0051] (1) MA, β-CD, and D4H were added to a DMF solvent in a mass ratio of 40:100:15, heated to 100 °C and stirred until dissolved uniformly. Then, a β-butylsulfonic acid-cyclodextrin catalyst at 3‰ of the mass of HP-β-CD was added and stirred for reaction for 5 h. After the reaction was completed, the solvent and unreacted raw materials were removed by distillation under reduced pressure at 120 °C to obtain a maleic acid-modified cyclodextrin / hydroxypolysiloxane complex.

[0052] (2) The maleic acid-modified cyclodextrin / hydroxypolysiloxane complex obtained in step (1) was added to a 75% ethanol aqueous solution at 75 °C and stirred until dissolved uniformly. Then, carnosine at 15% of the mass of the complex was added and stirred until dissolved uniformly. The resulting mixture was spray-dried under vacuum at 90 °C to obtain microcapsules of carnosine coated with the modified cyclodextrin complex.

[0053] (3) By mass percentage, 3% of the microcapsules of carnosine coated with the modified cyclodextrin complex, 0.06% of EMT-10, 0.1% of carbomer 940, 0.03% of HA (molecular weight of 1.3 million), 3% of amino acid humectant (betaine), 5% of EG-1, 0.3% of TEA, and the balance of water were homogenized and emulsified uniformly to obtain a supramolecular carnosine composition with a water replenishing effect of SMAPPT peptide.

[0054] Comparative Example 1

[0055] A moisturizing composition, compared with Example 1, does not contain microcapsules of carnosine coated with the modified cyclodextrin complex. The specific preparation method is as follows:

[0056] By mass percentage, 0.05% EMT-10, 0.15% carbomer 940, 0.02% HA (molecular weight of 1.3 million), 3% amino acid humectant (betaine), 5% EG-1, 0.3% TEA and the balance of water are homogenized and emulsified evenly to obtain a moisturizing composition.

[0057] Comparative Example 2

[0058] A supramolecular carnosine composition. Compared with Example 1, unmodified cyclodextrin is used to coat carnosine, and it includes the following preparation steps:

[0059] (1) HP-β-CD is added to an aqueous solution of 75% ethanol at 70 °C and stirred until dissolved evenly. Then, 20% of acetyl carnosine based on the mass of HP-β-CD is added and stirred until dissolved evenly. The obtained mixture is spray-dried under vacuum at 90 °C to obtain carnosine microcapsules coated with cyclodextrin.

[0060] (2) By mass percentage, 2% of carnosine microcapsules coated with cyclodextrin, 0.05% EMT-10, 0.15% carbomer 940, 0.02% HA (molecular weight of 1.3 million), 3% amino acid humectant (betaine), 5% EG-1, 0.3% TEA and the balance of water are homogenized and emulsified evenly to obtain a supramolecular carnosine composition.

[0061] I. The water replenishing effect (directly measuring the skin moisture content on the inner side of the forearm before and 10 minutes after use with a moisture tester; the data interpretation of the moisture probe is as follows: < 30, very dry; 30 - 45, dry; > 45, sufficient moisture) and the water locking effect (using the TEWL value (g / h / m 2 ) of the compositions obtained in the present invention (taking Example 1 as the test sample) and the compositions of Comparative Examples 1 and 2 are evaluated; the data interpretation is as follows: < 10, very healthy skin; 10 - 15, healthy skin; 15 - 25, normal skin; 25 - 30, sub-healthy skin; > 30, critical skin state) are tested, and the results are as Figure 1 and Figure 2 shown.

[0062] From Figure 1 and Figure 2The results showed that after 10 minutes of using the supramolecular carnosine composition of the present invention, the skin moisture increased from 45.70 before use to 85.24; the transepidermal water loss decreased from 24.42 before use to 9.56. Both the water replenishing effect and the water locking effect were significantly improved. Moreover, compared with Comparative Example 1 without adding the modified cyclodextrin complex-coated carnosine microcapsules and Comparative Example 2 using unmodified cyclodextrin to coat carnosine, the water replenishing effect and the water locking effect of the supramolecular carnosine composition of the present invention were more significant. It shows that the synergistic effect of the modified cyclodextrin complex-coated carnosine microcapsules and the humectant of the present invention is more significant.

[0063] Second, the repair and anti-aging effects of the compositions obtained in Examples 1-4 of the present invention and the compositions of Comparative Examples 1-2 were tested. The test method was to promote the proliferation of human skin fibroblasts (MTT assay), and the test results are as Figure 3 shown.

[0064] As Figure 3 the results showed, the supramolecular carnosine composition of the present invention can achieve a significantly improved repair and anti-aging effect by adding the modified cyclodextrin complex-coated carnosine microcapsules. The repair and anti-aging effect is mainly due to the antioxidant, anti-aging and repair-promoting activities of carnosine. Moreover, compared with the simple cyclodextrin-coated carnosine microcapsules, the supramolecular carnosine composition obtained by the modified cyclodextrin complex-coated carnosine microcapsules of the present invention can better exert the anti-aging and repair activities of the carnosine component.

[0065] Comparative Example 3

[0066] A preparation method of a supramolecular carnosine composition with the water replenishing effect of SMAPPT peptide, comprising the following preparation steps:

[0067] (1) MA and HP-β-CD were added to the DMF solvent at a mass ratio of 30:100, heated to 105 °C and stirred until dissolved evenly, then a butylsulfonic acid catalyst relative to 2‰ of the mass of HP-β-CD was added and stirred for 4 h. After the reaction was completed, the solvent and unreacted raw materials were removed by reduced pressure distillation at 120 °C to obtain maleic acid-modified cyclodextrin.

[0068] (2) The maleic acid-modified cyclodextrin obtained in step (1) and hydroxy-polysiloxane (obtained by catalytic ring-opening polymerization reaction of separate D4 in DMF solvent) were added to a 75% ethanol aqueous solution at 70 °C and stirred and mixed evenly, then 20% of acetyl carnosine based on the mass of the complex was added and stirred until dissolved evenly. The obtained mixed solution was spray-dried under vacuum at 90 °C to obtain modified cyclodextrin complex-coated carnosine microcapsules.

[0069] During the preparation process of this comparative example, it was found that hydroxy-polysiloxane was difficult to dissolve evenly in the ethanol aqueous solution, and the vacuum spray-drying process was difficult to proceed smoothly. Hydroxy-polysiloxane was easily precipitated, resulting in powder adhesion and nozzle blockage.

[0070] From the results of this comparative example, it can be seen that in the present invention, the esterification grafting / crosslinking reaction of cyclodextrin and the ring-opening polymerization reaction of cyclosiloxane are carried out simultaneously. By utilizing the formation of an interpenetrating network structure and hydrogen bond supramolecular interactions, the composite compatibility effect between hydroxy polysiloxane and maleic acid-modified cyclodextrin can be improved, and finally, good coating modification of the carnosine active ingredient can be achieved.

[0071] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any other changes, modifications, substitutions, combinations, and simplifications made without departing from the spirit and principle of the present invention shall be equivalent replacement methods and are all included in the protection scope of the present invention.

Claims

1. A preparation method of a supramolecular carnosine composition with a moisturizing effect, characterized in that, It includes the following preparation steps: (1) Add maleic anhydride, cyclodextrin raw material and cyclosiloxane into N,N-dimethylformamide solvent, heat to 90-120 °C and stir to dissolve evenly, then add an acidic catalyst and stir for reaction. After the reaction is completed, remove the solvent and unreacted raw materials by reduced pressure evaporation to obtain maleic acid modified cyclodextrin / hydroxyl polysiloxane complex; (2) Add the maleic acid modified cyclodextrin / hydroxyl polysiloxane complex obtained in step (1) into an ethanol aqueous solution and stir to dissolve evenly, then add carnosine raw material and stir to dissolve evenly. Spray dry the obtained mixed solution under vacuum to make powder to obtain carnosine microcapsules coated with modified cyclodextrin complex; (3) Homogenize and emulsify the carnosine microcapsules coated with modified cyclodextrin complex obtained in step (2) with an emulsifier, a thickener, a humectant and water evenly to obtain a supramolecular carnosine composition with a moisturizing effect.

2. The preparation method of a supramolecular carnosine composition with a moisturizing effect according to claim 1, characterized in that, In step (1), the cyclodextrin raw material is β-cyclodextrin or hydroxypropyl-β-cyclodextrin; the cyclosiloxane is tetramethyltetrahydrocyclotetrasiloxane or octamethylcyclotetrasiloxane.

3. The preparation method of a supramolecular carnosine composition with a moisturizing effect according to claim 2, characterized in that, The addition amount of maleic anhydride is 10%-60% of the mass of the cyclodextrin raw material, and the addition amount of the cyclosiloxane is 10%-40% of the mass of the cyclodextrin raw material.

4. The preparation method of a supramolecular carnosine composition with a moisturizing effect according to claim 1, characterized in that, In step (1), the acidic catalyst is butylsulfonic acid, β-butylsulfonic acid-cyclodextrin or p-toluenesulfonic acid; the addition amount of the acidic catalyst is 0.1%-0.5% of the mass of the cyclodextrin raw material; the stirring reaction time is 2-6 h.

5. The preparation method of a supramolecular carnosine composition with a moisturizing effect according to claim 1, characterized in that, In step (2), the ethanol aqueous solution refers to an ethanol aqueous solution with an ethanol mass fraction of 50%-80%; the carnosine raw material is at least one of acetyl carnosine, decarboxylated carnosine, carnosine; the addition amount of the carnosine raw material is 5%-30% of the mass of the maleic acid modified cyclodextrin / hydroxyl polysiloxane complex.

6. The preparation method of a supramolecular carnosine composition with a moisturizing effect according to claim 1, characterized in that, In step (2), the temperature of the stirring dissolution does not exceed 80 °C, and the temperature of the vacuum spray drying does not exceed 100 °C.

7. The preparation method of a supramolecular carnosine composition with a moisturizing effect according to claim 1, characterized in that, In step (3), the emulsifier is a copolymer of hydroxyethyl acrylate / sodium acryloyldimethyltaurate; the thickener is carbomer; the humectant is at least one of hyaluronic acid, amino acid humectant, glycerol polyether-26, triethanolamine.

8. The preparation method of a supramolecular carnosine composition with a moisturizing effect according to claim 1, characterized in that, In step (3), the mass percentage content ratio of each component is as follows: Carnosine microcapsules coated with modified cyclodextrin complex 0.5%-5%, emulsifier 0.02%-0.1%, thickener 0.05%-0.3%, humectant 4%-12%, and the balance is water.

9. A supramolecular carnosine composition with a moisturizing effect, characterized in that, Prepared by the method according to any one of claims 1-8.

10. Application of a supramolecular carnosine composition with a moisturizing effect according to claim 9 in the preparation of essence, skin cream, facial mask and other skin care products.

Images