Composition for shampooing with anti-dandruff and antipruritic effects and preparation method thereof

Abstract

The invention belongs to the technical field of daily necessities, and specifically relates to a composition for shampooing with anti-dandruff and antipruritic effects and a preparation method thereof, comprising the following components: piroctone olamine salt, BIOTA ORIENTALIS leaf extract, PUERARIA LOBATA extract, ANEM ARRHENA ASPHODELOIDES root extract and SAPINDUS MUKORO SSI fruit extract. Chemical anti-dandruff and antipruritic agents are effectively compounded with plant extracts to overcome the defects of a single type of anti-dandruff and antipruritic agent, and the composition is mild, efficient, widely applicable, and can effectively improve the effects of removing dandruff and relieving scalp itching.

Description

Technical Field

[0001] The invention belongs to the technical field of daily necessities, and in particular relates to a composition for shampooing with anti-dandruff and antipruritic effects and a preparation method thereof. Background Art

[0002] Dandruff is the keratinocytes that fall off from the scalp. Under normal circumstances, the keratinocytes fall off very little and very slowly, and it is not obviously visible, but when this process is accelerated or the cells are not completely shed, visible dandruff may form. Dandruff can be dry, flaky, or oily. Dandruff problems are often accompanied by itchy scalp, which brings troubles to people's daily lives. There may be many reasons why dandruff is often accompanied by itchy scalp. For example, dry skin may cause dandruff and itching; the scalp is sensitive to the chemical ingredients in certain hair care products, which may also cause dandruff and itching; seborrheic dermatitis often manifests as redness, itching, dryness and flaking of the scalp; Malassezia feeds on the oil on the scalp, and excessive reproduction may cause dandruff and itching. Increased mental stress, seasonal changes in climate, and bad living habits may all cause or aggravate dandruff and scalp itching.

[0003] Anti-dandruff and anti-itching shampoo products on the market mainly use chemical anti-dandruff and anti-itching agents. Although they are effective in removing dandruff and relieving itching, they have some shortcomings, such as: (1) Chemical anti-dandruff and anti-itching agents such as salicylic acid and selenium disulfide are highly irritating and may cause damage to the skin; (2) Using chemical anti-dandruff and anti-itching agents may make the hair feel rough and astringent. If not rinsed thoroughly, the hair may lose color and even accelerate hair loss; (3) Some chemical anti-dandruff and anti-itching agents may have odors, affecting the user experience; (4) The safety of the chemical anti-dandruff and anti-itching agent zinc pyrithione (ZPT) has been questioned, and this ingredient has gradually been replaced by other safer and milder ingredients. Although shampoo products that use natural ingredients as anti-dandruff and anti-itching agents are mild, the effects are often not good.

[0004] Therefore, it is crucial to provide a suitable shampoo product that should be highly safe and able to effectively remove dandruff and relieve scalp itching. Summary of the invention

[0005] The present invention provides a composition for shampooing with anti-dandruff and antipruritic effects and a preparation method thereof, which effectively compound chemical anti-dandruff and antipruritic agents with plant extracts, overcome the defects of a single type of anti-dandruff and antipruritic agent, is mild and highly effective, is widely applicable, and can effectively improve the effects of removing dandruff and relieving scalp itching.

[0006] The invention provides a composition for shampooing with anti-dandruff and antipruritic effects, which contains the following components: piroctone olamine salt, BIOTA ORIENTALIS leaf extract, PUERARI A LOBATA extract, ANEMARRHENA ASPHODELOIDES root extract and SAPINDUS MUKOROSSI fruit extract.

[0007] Preferably, a composition for shampooing with anti-dandruff and antipruritic effects comprises the following components by weight: 1 to 30 parts of piroctone olamine salt,

[0008] 0.1-20 parts of BIOTA ORIENTALIS leaf extract,

[0009] 0.01 to 8 parts of Pueraria lobata extract,

[0010] 0.1-20 parts of Anemarrhena asphodeloides root extract, and

[0011] 0.1-20 parts of SAPINDUS MUKOROSSI fruit extract.

[0012] Preferably, a composition for shampooing with anti-dandruff and antipruritic effects comprises the following components by weight: 5 to 15 parts of piroctone olamine salt,

[0013] 8-15 parts of BIOTA ORIENTALIS leaf extract,

[0014] 4-8 parts of Pueraria lobata extract,

[0015] 12-18 parts of Anemarrhena asphodeloides root extract, and

[0016] 5-15 parts of SAPINDUS MUKOROSSI fruit extract.

[0017] The present invention provides application of the composition for shampooing with anti-dandruff and antipruritic effects in preparing hair products.

[0018] Preferably, the composition for shampooing with anti-dandruff and antipruritic effects is used in the preparation of hair products, and the hair products are selected from shampoo, shampoo cream, hair conditioner and hair mask.

[0019] Preferably, the use of the composition for shampooing with anti-dandruff and anti-itching effects in the preparation of hair products, the mass percentage of the composition for shampooing with anti-dandruff and anti-itching effects in the hair products is 4-10%.

[0020] The invention provides a shampoo product, comprising the composition for shampooing with the effects of removing dandruff and relieving itching.

[0021] Preferably, a shampoo product contains the following components by mass percentage:

[0022] 4-10% of a composition for shampooing with anti-dandruff and antipruritic effects;

[0023] Thickener 1-15%;

[0024] Surfactant 10-30%;

[0025] Moisturizer 10-30%;

[0026] Preservatives 0.01-0.1%;

[0027] pH regulator 0.01~3.0%;

[0028] Flavors and fragrances 0-0.5%; and

[0029] Deionized water balance.

[0030] Preferably, the thickener can be selected from one or more of hydroxypropyl methylcellulose, carbomer, xanthan gum, stearyl alcohol, cetyl alcohol, and polyurethane-10.

[0031] Preferably, the surfactant can be selected from one or more of sodium laureth sulfate, cocoyl glucoside, sodium cocoyl isethionate, cocamide MEA, cocamidopropyl betaine, PEG-60 hydrogenated castor oil, laureth-2, and lauramidopropyl betaine.

[0032] Preferably, the moisturizing agent can be selected from one or more of butylene glycol, 1,3-propylene glycol, glycerol, 1,2-hexanediol, 1,2-pentanediol, glycerol, caprylyl glycol, α-glucan oligosaccharide, and allantoin.

[0033] Preferably, the preservative can be selected from one or more of phenoxyethanol, potassium sorbate, sodium benzoate, DMDM ​​hydantoin, methylisothiazolinone and methylparaben.

[0034] Preferably, the pH adjuster can be selected from one or more of citric acid, sodium citrate, tartaric acid, hydrochloric acid and sodium acetate.

[0035] Preferably, the flavor and fragrance can be selected from one or more of limonene, hexyl cinnamaldehyde, geraniol and linalool.

[0036] The invention provides a preparation method of a composition for shampooing with anti-dandruff and antipruritic effects, comprising the following steps: accurately weighing each component by weight, firstly mixing BIOTA ORIENTALIS leaf extract, PUERARIALOBATA root extract, ANEMARRHENA ASPH ODELOIDES root extract and SAPINDUSMUS MUKOROSSI fruit extract uniformly, then adding piroctone ethanolamine salt, and continuing to mix uniformly to obtain the composition.

[0037] The present invention provides a method for preparing a shampoo product, comprising the following steps:

[0038] 1) Heat the surfactant and thickener to 80-90°C and stir for 40-60 minutes to mix evenly, keep warm for 20-30 minutes and then cool to 30-45°C to obtain a mixture A;

[0039] 2) Mix the anti-dandruff and antipruritic composition for shampoo, moisturizer and deionized water, heat to 30-50° C., stir for 20-45 minutes, and mix well to obtain a mixture B;

[0040] 3) Evenly mix the mixture A obtained in step 1), the mixture B obtained in step 2), the pH adjuster, the preservative and the flavors and fragrances to obtain the product.

[0041] The beneficial technical effects of the present invention are:

[0042] The invention effectively compounds the chemical anti-dandruff and antipruritic agent piroctone ethanolamine with plant extracts including BIOTAORIENTALIS leaf extract, PUERARIA LOBATA extract, ANEM ARRHENAASPHODELOIDES root extract and SAPINDUS MUKOROOSS I fruit extract, thereby overcoming the defects of a single type of anti-dandruff and antipruritic agent, being mild, highly effective and widely applicable, and being able to effectively enhance the effects of removing dandruff and alleviating scalp itching, thus producing significant improvement. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 is the average concentration of TNF-α in each group of the present invention;

[0044] Figure 2 It is the average value of IL-6 concentration in each group of the present invention. DETAILED DESCRIPTION

[0045] In order to more fully understand the technical content of the present invention, the present invention will be further introduced and illustrated in conjunction with specific embodiments below; obviously, the embodiments described below are only part of the embodiments of the present invention, rather than all of the embodiments; based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present invention.

[0046] Table 1 Examples 1-3 Compositions for shampooing with anti-dandruff and antipruritic effects (in parts by weight)

[0047]

[0048] Comparative Examples 1-4 are basically the same as Example 1, except for the ratio of the plant extracts in the composition for shampooing with anti-dandruff and antipruritic effects, as shown in Table 2.

[0049] Table 2 Comparative Examples 1-5 Compositions with anti-dandruff and antipruritic effects for shampooing (in parts by weight)

[0050]

[0051] Comparative Example 6

[0052] Comparative Example 6 is substantially the same as Example 1, except that an equal amount of ginger root extract is used to replace the SAPINDUS MUKOROSSI fruit extract.

[0053] Comparative Example 7

[0054] Comparative Example 7 is substantially the same as Example 1, except that an equal amount of ginseng root extract is used to replace the pueraria lobata extract.

[0055] Test 1

[0056] The purchased Malassezia furfur ATCC44344 was revived and activated and then stably cultured, and a culture medium was used to prepare about 10 5 CFU / mL concentration of bacterial suspension. Take the composition for shampooing with anti-dandruff and antipruritic effect prepared in Examples 1-3 and Comparative Examples 1-7, and dilute it with culture medium to a sample solution of 15v / v%. Take 1mL of bacterial suspension in a test tube, add 2mL of sample solution to the test group, and add 2mL of culture medium to the control group. After the bacterial suspension and the sample solution are mixed evenly, start timing, set the detection time points of 5min, 10min, and 30min, and take 1mL of the mixed solution respectively, and use the live bacteria culture counting method to determine the number of live bacteria. The measurement results are shown in Table 3.

[0057] Table 3: Inhibition rate of Malassezia furfur ATCC44344 (%)

[0058]

[0059] Piroctone olamine salt has a broad-spectrum antibacterial property and can be used to treat dandruff and seborrheic dermatitis, and relative to bacteria, piroctone olamine salt has a more excellent antibacterial effect on fungi. The results of the present test examples 1-3 and comparative example 5 show that the compounding of piroctone olamine salt and plant extract has a better inhibitory effect on Malassezia furfur ATCC44344 than the use of plant extract alone.

[0060] The present invention has obtained a combination of BIOTA ORIENTALIS leaf extract, PUERARIA LOBATA extract, ANEMARRHENA ASPHO DELOIDES root extract, and SAPINDUS MUKOROSSI fruit extract through a large number of screening tests in the early stage. The results of Examples 1-3 and Comparative Examples 1-4 and 6-7 in this test show that when the total amount of plant extracts is consistent, discarding or replacing any one of the extracts will directly affect the inhibitory effect on Malassezia furfur ATCC44344.

[0061] Test 2

[0062] The purchased RAW264.7 cells were revived and stably subcultured at a rate of 5×10 5 The cells were inoculated at a density of 100 μL / mL in a 96-well plate, and the following culture media were replaced after 24 hours of culture, with 3 replicate wells set up for each group: Blank group: 200 μL complete culture medium (DMEM medium containing 10% FBS);

[0063] Negative control group: 20 μL LPS (1 μg / mL) + 180 μL complete medium;

[0064] Example group: 20 μL LPS (1 μg / mL) + 178 μL complete medium + 2 μL of the composition of each group of Examples 1-3;

[0065] Comparative example group: 20 μL LPS (1 μg / mL) + 178 μL complete culture medium + 2 μL of the composition of each group of comparative examples 1-7.

[0066] After the RAW264.7 cells were cultured for 24 hours, the concentrations of TNF-α and IL-6 in the cell supernatant of each group were measured according to the instructions of the ELISA kit, and the average concentration of each group was calculated. Figure 1 , Figure 2 .

[0067] The generation of skin pruritus is a complex, multi-factorial result, and its mechanism is not completely clear, but studies have found that various mediators, such as cytokines such as TNF-α, IL-6, IL-2, and IL-31, play an important role in the mechanism of pruritus. This test result shows that the compounding of piroctone ethanolamine salt and four kinds of plant extracts can significantly inhibit the secretion of TNF-α and IL-6 induced by LPS in in vitro cell experiments, and effectively play an anti-inflammatory and antipruritic effect. The results of embodiment 1-3 and comparative examples 1-4 and 6-7 confirm that the specific combination of BIOTA ORIENTALIS leaf extract, PUERARIALOBAT A extract, ANEMARRHENA ASPHODELOIDES root extract, and SAPINDUSMUS MUKOROSSI fruit extract obtained by the present invention screening is an effective guarantee for inhibiting TNF-α and IL-6 secretion.

[0068] Test 3

[0069] 80 healthy volunteers with dandruff and itchy scalp were recruited, with an age range of 20 to 40 years old. The volunteers were randomly divided into 8 groups, with 10 cases in each group. The shampoo prepared from the composition with anti-dandruff and antipruritic effects for shampooing of Example 1 and Comparative Examples 1-7 was used respectively. The anti-dandruff and antipruritic effects of the shampoo were sensory evaluated. The shampoo was used 2 to 3 times a week, and the scalp was massaged with the shampoo for at least 2 minutes during washing. The shampoo was used continuously for 8 weeks. After 8 weeks, a scoring system of 1 to 10 points was used, with 1 point indicating completely ineffective and 10 points indicating very effective. The sensory evaluation results are shown in Table 5.

[0070] Table 4 Shampoo prepared from the composition with anti-dandruff and antipruritic effect for shampooing of Example 1 and Comparative Examples 1-7 (wt%)

[0071]

[0072] Table 5 Sensory evaluation results

[0073]

[0074]

[0075] This experiment shows that the shampoo prepared by the composition for shampooing with anti-dandruff and antipruritic effect of the present invention can effectively remove dandruff and improve the symptoms of itchy scalp. The compounding of piroctone olamine salt with BIOTAORIENTALIS leaf extract, PUERARIA LOBATA extract, ANEMARRHENAASPHODELOIDES root extract and SAPINDUS MUKOROSSI fruit extract overcomes the defects of a single type of anti-dandruff and antipruritic agent, is mild and efficient, and is applicable to a wide range of groups.

[0076] The above contents are further detailed descriptions of the present invention in combination with specific preferred embodiments, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, several simple deductions or substitutions can be made without departing from the concept of the present invention, which should be regarded as falling within the protection scope of the present invention.

Claims

1. A composition for shampooing with anti-dandruff and antipruritic effects, comprising the following components: By weight, the ingredients include 5-15 parts of piroctone olamine salt, 8-15 parts of Platycladus orientalis leaf extract, 4-8 parts of Pueraria root extract, 12-18 parts of Anemarrhena root extract and 5-15 parts of Sapindus mukorossi fruit extract.

2. Use of the composition for shampooing having anti-dandruff and antipruritic effects according to claim 1 in the preparation of hair products, characterized in that: The mass percentage of the composition for shampooing with anti-dandruff and antipruritic effects in the hair product is 4-10%.

3. The use according to claim 2, characterized in that: The hair product is selected from shampoo, shampoo cream, hair conditioner and hair mask.

4. The method for preparing the composition for shampooing with anti-dandruff and antipruritic effects according to claim 1, comprising the following steps: accurately weighing each component by weight, first mixing the Platycladus orientalis leaf extract, Pueraria root extract, Anemarrhena root extract and Sapindus mukorossi fruit extract, then adding piroctone ethanolamine salt, and continuing to mix evenly to obtain the composition.

5. A shampoo product, comprising the following components by mass percentage: 4-10% of the composition for shampooing with anti-dandruff and antipruritic effects as claimed in claim 1; Thickener 1~15%; Surfactant 10~30%; Moisturizer 10~30%; Preservatives 0.01~0.1%; pH adjuster 0.01~3.0%; Flavors and fragrances 0~0.5%; and Deionized water balance; The preservative is selected from one or more of phenoxyethanol, potassium sorbate, sodium benzoate, DMDM ​​hydantoin, methylisothiazolinone and methylparaben.

6. The shampoo product according to claim 5, characterized in that The thickener is selected from one or more of hydroxypropyl methylcellulose, carbomer, xanthan gum, stearyl alcohol, cetyl alcohol, and polyurethane-10; The surfactant is selected from one or more of sodium laureth sulfate, cocoyl glucoside, sodium cocoyl isethionate, cocamide MEA, cocamidopropyl betaine, PEG-60 hydrogenated castor oil, laureth-2, and lauramidopropyl betaine; the moisturizer is selected from one or more of butylene glycol, 1,3-propylene glycol, 1,2-hexanediol, 1,2-pentanediol, glycerin, caprylyl glycol, α-glucan oligosaccharide, and allantoin.

7. The shampoo product according to claim 6, characterized in that The pH regulator is selected from one or more of citric acid, sodium citrate, tartaric acid, hydrochloric acid, and sodium acetate; the flavor and fragrance is selected from one or more of limonene, hexyl cinnamaldehyde, geraniol, and linalool.

Images