A detachable magnetically driven biopsy sampling capsule system

Abstract

The present invention provides a detachable magnetically driven biopsy sampling capsule system, comprising: a first capsule, responsible for actively moving to the lesion area; a second capsule, which performs biopsy sampling after reaching the lesion area under the traction of the first capsule; a separation mechanism, through which the first capsule and the second capsule are connected before the second capsule completes the biopsy sampling, and the separation mechanism separates the first capsule from the second capsule after the second capsule completes the biopsy sampling; and a traction removal mechanism, which removes the second capsule from the oral cavity after the first capsule and the second capsule are separated. The beneficial effect of the present invention is that the second capsule of the detachable magnetically driven biopsy sampling capsule system can be immediately removed after the sampling is completed, and the sampling results can be obtained immediately, so it will not be affected by the patient's digestive cycle, and is more convenient than the original wireless magnetically driven biopsy capsule.

Description

Technical Field

[0001] The present invention relates to medical devices, and in particular to a detachable magnetically driven biopsy sampling capsule system. Background Art

[0002] A capsule endoscope (CE) is an ingestible medical device used to examine the human gastrointestinal tract. It is typically equipped with one or two miniature cameras to capture images of the GI tract. Doctors can then assess health by examining these images. Building on this, the new magnetically driven biopsy capsule combines biopsy and active motion capabilities. Driven by an external magnetic field, it can actively move and coordinate with the miniature camera to reach the lesion site for biopsy.

[0003] Existing magnetically driven biopsy capsules are all wireless capsule endoscopes with a high degree of functional integration. After completing the biopsy task in the human GI tract, they need to be expelled from the body through intestinal peristalsis before the sampling results can be obtained. This causes the sampling cycle of the biopsy capsule to be affected by the patient's digestive cycle, which is not conducive to obtaining biopsy results in a timely manner.

[0004] Therefore, how to overcome the problem that the current magnetically driven biopsy capsule has a long sampling cycle and is inconvenient for obtaining sampling results in a timely manner is a technical problem that needs to be solved urgently by those skilled in the art. Summary of the Invention

[0005] In order to overcome the problem that the current magnetically driven biopsy capsule has a long sampling cycle and is inconvenient for obtaining sampling results in a timely manner, the present invention provides a detachable magnetically driven biopsy sampling capsule system.

[0006] The purpose of the present invention is to provide a new type of detachable magnetically driven biopsy sampling capsule system, which can be taken out immediately after the sampling is completed, so it will not be affected by the patient's digestive cycle. Compared with the original wireless magnetically driven biopsy capsule, it is more convenient.

[0007] The present invention provides a detachable magnetically driven biopsy sampling capsule system, comprising:

[0008] The first capsule is responsible for active movement to the lesion area;

[0009] a second capsule, which reaches the lesion area under the traction of the first capsule and performs biopsy sampling;

[0010] a separation mechanism, wherein before the second capsule completes the biopsy sampling, the first capsule and the second capsule are connected via the separation mechanism, and after the second capsule completes the biopsy sampling, the separation mechanism separates the first capsule from the second capsule;

[0011] The pulling and removing mechanism is used to remove the second capsule from the oral cavity after the first capsule is separated from the second capsule.

[0012] As a further improvement of the present invention, after the first capsule is separated from the second capsule, the first capsule is discharged from the human body along the gastrointestinal tract.

[0013] As a further improvement of the present invention, the second capsule includes a capsule shell, a biopsy sampling needle installed in the capsule shell, and a magnet installed in the capsule shell. The magnet is connected to the biopsy sampling needle, and the magnet can drive the biopsy sampling needle to move back and forth between the initial position and the biopsy sampling position.

[0014] As a further improvement of the present invention, the separation mechanism adopts a releasable rope mechanism.

[0015] As a further improvement of the present invention, the releasable rope mechanism includes a release rope mechanism, a first connecting rope rod and a release rope, the release rope mechanism is installed on the magnet, the first connecting rope rod is fixed inside the capsule shell, one end of the release rope is connected to the first capsule, and the other end of the release rope is wrapped around the first connecting rope rod and is limited between the release rope mechanisms. During biopsy sampling, the magnet drives the biopsy sampling needle to move from the initial position to the biopsy sampling position, and drives the release rope mechanism to move synchronously. When the biopsy sampling needle reaches the biopsy sampling position, the release rope mechanism drives the release rope to disengage from the first connecting rope rod, and the first capsule is separated from the second capsule.

[0016] As a further improvement of the present invention, the release rope mechanism includes a first limit plate and a second limit plate, both of which are fixed on the magnet, and both of which are provided with through holes for the first connecting rope rod to pass through. When the magnet drives the biopsy sampling needle to move from the initial position to the biopsy sampling position, the release rope mechanism drives the release rope to move from the connection position to the separation position. When the release rope is in the connection position, the first connecting rope rod passes through the first limit plate and the second limit plate, and the release rope is wrapped around the first connecting rope rod and is limited between the first limit plate and the second limit plate. When the release rope is in the separation position, the first connecting rope rod disengages from at least one of the first limit plate and the second limit plate, so that the release rope disengages from the first connecting rope rod, and the first capsule is separated from the second capsule.

[0017] As a further improvement of the present invention, the magnet is connected to a reset spring. After the biopsy sampling needle completes the biopsy sampling, the reset spring drives the magnet to drive the biopsy sampling needle to move from the biopsy sampling position to the initial position.

[0018] As a further improvement of the present invention, the traction and removal mechanism includes an external traction rope, a second connecting rope rod is fixed inside the capsule shell, one end of the external traction rope is connected to the second connecting rope rod, and the other end of the external traction rope is located outside the body. After the first capsule is separated from the second capsule, the second capsule is removed from the oral cavity through the external traction rope.

[0019] As a further improvement of the present invention, the magnet and the biopsy sampling needle are detachably connected, and biopsy sampling needles of different models can be replaced.

[0020] As a further improvement of the present invention, the detachable magnetically driven biopsy sampling capsule system also includes an external magnetic control platform, which can drive the first capsule to actively move to the lesion area, and the external magnetic control platform can drive the magnet to drive the biopsy sampling needle to move from the initial position to the biopsy sampling position.

[0021] As a further improvement of the present invention, the first capsule is also called a commercial capsule, which is mainly composed of a capsule shell, a micro camera and a magnet, and the magnet is located inside the capsule shell.

[0022] As a further improvement of the present invention, the external magnetic control platform is composed of an external electromagnetic drive system, and the external electromagnetic drive system is composed of 7 rectangular electromagnetic coils, which are used to drive the first capsule to move and the second capsule to sample.

[0023] As a further improvement of the present invention, after the first capsule and the second capsule are swallowed into the human body, the patient is placed on an external magnetic control platform, and the external electromagnetic drive system can drive the first capsule to the lesion location in the gastrointestinal tract, while the second capsule reaches the lesion location in the gastrointestinal tract under the drive of the first capsule.

[0024] As a further improvement of the present invention, the shape of the capsule shells of the first capsule and the second capsule can be cylindrical, rhombus-shaped or olive-shaped. The magnet inside the capsule shell can be one or more.

[0025] As a further improvement of the present invention, the active motion function is separated from the sampling function by the first capsule and the second capsule, thereby reducing the size of a single capsule and allowing the capsule size to be flexibly changed.

[0026] As a further improvement of the present invention, the second capsule is also called a magnetically driven sampling capsule. After completing the sampling task, it is disconnected from the first capsule. The sampling results can be obtained by pulling the external traction rope connected to the second capsule out of the patient's mouth. Therefore, it will not be affected by the patient's digestive cycle. Compared with the original wireless magnetically driven biopsy capsule, it is more convenient.

[0027] As a further improvement of the present invention, the capsule shells of the first capsule and the second capsule are both composed of two left and right shells, which are bonded together with glue, making assembly convenient.

[0028] The beneficial effect of the present invention is that it provides a new type of detachable magnetically driven biopsy sampling capsule system. The second capsule of the detachable magnetically driven biopsy sampling capsule system can be taken out immediately after the sampling is completed, and the sampling results can be obtained immediately. Therefore, it will not be affected by the patient's digestive cycle. Compared with the original wireless magnetically driven biopsy capsule, it is more convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other solutions can be obtained based on these drawings without paying any creative work.

[0030] Figure 1 FIG. 1 is a cross-sectional structural diagram of a second capsule in an example of the present invention.

[0031] Figure 2 It is a cross-sectional three-dimensional structural diagram of the second capsule in one example of the present invention.

[0032] Figure 3 Schematic diagram of a first capsule pulling a second capsule to a target position in an example of the present invention.

[0033] Figure 4 It is a schematic diagram of the second capsule sampling and separating from the first capsule in an example of the present invention.

[0034] Figure 5 Schematic diagram of the second capsule being pulled out in one embodiment of the present invention. DETAILED DESCRIPTION

[0035] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0036] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the scope of protection of the present invention. In addition, the terms "first", "second" and the like are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, features defined as "first", "second" and the like may explicitly or implicitly include one or more of the features. In the description of the present invention, unless otherwise specified, "multiple" means two or more.

[0037] In the description of the present invention, it should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood broadly. For example, they may refer to fixed connections, detachable connections, or integral connections; they may refer to direct connections, indirect connections through an intermediate medium, or internal communication between two components. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on specific circumstances.

[0038] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0039] like Figures 1 to 4 As shown, a detachable magnetically driven biopsy sampling capsule system comprises:

[0040] The first capsule 100, also known as the commercial capsule, is responsible for active movement to the lesion area;

[0041] The second capsule 200, also known as the magnetically driven sampling capsule, reaches the lesion area under the traction of the first capsule 100 and performs biopsy sampling;

[0042] a separation mechanism, wherein before the second capsule 200 completes the biopsy sampling, the first capsule 100 and the second capsule 200 are connected via the separation mechanism, and after the second capsule 200 completes the biopsy sampling, the separation mechanism separates the first capsule 100 from the second capsule 200;

[0043] The pulling and removing mechanism is used to remove the second capsule 200 from the oral cavity after the first capsule 100 and the second capsule 200 are separated.

[0044] After the first capsule 100 is separated from the second capsule 200 , the first capsule 100 is discharged from the human body along the gastrointestinal tract.

[0045] The second capsule 200 includes a capsule shell 1, a biopsy sampling needle 4 installed in the capsule shell 1, and a magnet 2 installed in the capsule shell 1. The magnet 2 is connected to the biopsy sampling needle 4, and the magnet 2 can drive the biopsy sampling needle 4 to move back and forth between the initial position and the biopsy sampling position.

[0046] The separation mechanism adopts a releasable rope mechanism.

[0047] The releasable rope mechanism includes a release rope mechanism 3, a first connecting rope rod 6 and a release rope 300. The release rope mechanism 3 is installed on the magnet 2, and the first connecting rope rod 6 is fixed inside the capsule shell 1. One end of the release rope 300 is connected to the first capsule 100, and the other end of the release rope 300 is wrapped around the first connecting rope rod 6 and is limited between the release rope mechanism 3. During biopsy sampling, the magnet 2 drives the biopsy sampling needle 4 to move from the initial position to the biopsy sampling position, and drives the release rope mechanism 3 to move synchronously. When the biopsy sampling needle 4 reaches the biopsy sampling position, the release rope mechanism 3 drives the release rope 300 to disengage from the first connecting rope rod 6, and the first capsule 100 is separated from the second capsule 200.

[0048] The release rope mechanism 3 includes a first limiting plate 31 and a second limiting plate 32, both of which are fixed on the magnet 2. The first limiting plate 31 and the second limiting plate 32 are both provided with a through hole for the first connecting rope rod 6 to pass through. When the magnet 2 drives the biopsy sampling needle 4 to move from the initial position to the biopsy sampling position, the release rope mechanism 3 drives the release rope 300 to move from the connection position to the separation position. When the release rope 300 is in the connection position, the first connecting rope rod 6 passes through the first limiting plate 31 and the second limiting plate 32, and the release rope 300 Wrapped around the first connecting rod 6 and limited between the first limiting plate 31 and the second limiting plate 32, when the release rope 300 is in the separation position, the first connecting rod 6 is disengaged from at least one of the first limiting plate 31 and the second limiting plate 32 (for example, the first connecting rod 6 is disengaged from the second limiting plate 32, or the first connecting rod 6 is disengaged from the first limiting plate 31, or the first connecting rod 6 is disengaged from the first limiting plate 31 and the second limiting plate 32), so that the release rope 300 is disengaged from the first connecting rod 6, and the first capsule 100 is separated from the second capsule 200.

[0049] The magnet 2 is connected to a return spring 5. After the biopsy sampling needle 4 completes the biopsy sampling, the return spring 5 drives the magnet 2 to drive the biopsy sampling needle 4 to move from the biopsy sampling position to the initial position.

[0050] The return spring 5 is connected to a support rod for installing and guiding the return spring 5 .

[0051] The traction and removal mechanism includes an external traction rope 400, and a second connecting rope rod 7 is fixed inside the capsule shell 1. One end of the external traction rope 400 is connected to the second connecting rope rod 7, and the other end of the external traction rope 400 is located outside the body. After the first capsule 100 and the second capsule 200 are separated, the second capsule 200 is removed from the oral cavity through the external traction rope 400.

[0052] The magnet 2 is detachably connected to the biopsy sampling needle 4, and biopsy sampling needles of different models can be replaced.

[0053] The detachable magnetically driven biopsy sampling capsule system also includes an external magnetic control platform, which can drive the first capsule 100 to actively move to the lesion area, and the external magnetic control platform can drive the magnet 2 to drive the biopsy sampling needle 4 to move from the initial position to the biopsy sampling position.

[0054] The first capsule 100 moves under the action of the external electromagnetic drive system. The first capsule 100 is connected to the second capsule 200 by a release rope 300, which drives the second capsule 200 to move and cooperate with the micro camera to reach the designated position. Figure 3 It is a schematic diagram of the above process in an embodiment of the present invention.

[0055] After the first capsule 100 and the second capsule 200 arrive at the position, under the action of the external electromagnetic drive system, the biopsy sampling needle 4 inside the second capsule 200 pops out to take samples, and at the same time disconnects from the first capsule 100. Figure 4 It is a schematic diagram of the above process in an embodiment of the present invention.

[0056] After completing the sampling task, the external electromagnetic drive system cancels the magnetic field, the biopsy sampling needle 4 is retracted, and the second capsule 200 is pulled by the external traction rope 400 connected to the outside world and taken out from the esophagus, while the first capsule 100 remains in the gastrointestinal tract and is excreted from the body with the digestive activity. Figure 5 It is a schematic diagram of the above process in an embodiment of the present invention.

[0057] The present invention provides a detachable magnetically driven biopsy sampling capsule system, in which the second capsule 200 of the system can be directly removed after the sampling activity is completed, reducing the time required for biopsy sampling. Compared with the wireless magnetically driven capsule sampling method used in the prior art, this method has higher sampling efficiency and lower time cost. In this system, the activities of active movement and biopsy sampling are respectively undertaken by the first capsule 100 and the second capsule 200. Compared with the integrated capsule of the prior art, the functions are more independent, the size is smaller, and the application scenarios are more extensive. The structure of the first capsule 100 and the second capsule 200 in the system is simpler, the assembly method is simpler than the integrated capsule of the prior art, and the cost is lower.

[0058] The present invention provides a detachable magnetically driven biopsy sampling capsule system, which has the following advantages:

[0059] 1. The magnetically driven sampling capsule (ie, the second capsule 200) can be separated from the commercial capsule (ie, the first capsule 100) and directly pulled out from the mouth, thereby greatly reducing the time required for sampling.

[0060] 2. The magnetically driven sampling capsule (i.e., the second capsule 200) and the commercial capsule (i.e., the first capsule 100) have strong functional specificity, and their sizes can be optimized to improve their performance.

[0061] 3. The system is easy to use and highly safe. Even if the magnetically driven sampling capsule (ie, the second capsule 200) and the commercial capsule (ie, the first capsule 100) are separated due to misoperation, there is no safety concern.

[0062] 4. Provide fault tolerance for sampling biopsy. Even if one sampling fails, a second sampling can be performed in a short time, saving sampling time and cost.

[0063] The above is a further detailed description of the present invention in conjunction with specific preferred embodiments, and the specific implementation of the present invention should not be considered to be limited to these descriptions. For those skilled in the art of the present invention, without departing from the concept of the present invention, several simple deductions or substitutions can be made, which should be considered to fall within the scope of protection of the present invention.

Claims

1. A detachable magnetically driven biopsy sampling capsule system, characterized in that: include: The first capsule is responsible for active movement to the lesion area; a second capsule, which reaches the lesion area under the traction of the first capsule and performs biopsy sampling; a separation mechanism, wherein before the second capsule completes the biopsy sampling, the first capsule and the second capsule are connected via the separation mechanism, and after the second capsule completes the biopsy sampling, the separation mechanism separates the first capsule from the second capsule; a pulling and removing mechanism for removing the second capsule from the oral cavity after the first capsule is separated from the second capsule; The second capsule includes a capsule shell, a biopsy sampling needle installed in the capsule shell, and a magnet installed in the capsule shell, wherein the magnet is connected to the biopsy sampling needle and can drive the biopsy sampling needle to move back and forth between an initial position and a biopsy sampling position; The separation mechanism adopts a releasable rope mechanism; The releasable rope mechanism includes a release rope mechanism, a first rope connecting rod and a release rope, wherein the release rope mechanism is installed on the magnet, the first rope connecting rod is fixed inside the capsule shell, one end of the release rope is connected to the first capsule, and the other end of the release rope is wound around the first rope connecting rod and is limited between the release rope mechanisms. During biopsy sampling, the magnet drives the biopsy sampling needle to move from the initial position to the biopsy sampling position, and drives the release rope mechanism to move synchronously. When the biopsy sampling needle reaches the biopsy sampling position, the release rope mechanism drives the release rope to disengage from the first rope connecting rod, and the first capsule is separated from the second capsule.

2. The detachable magnetically driven biopsy sampling capsule system according to claim 1, characterized in that: After the first capsule is separated from the second capsule, the first capsule is discharged from the human body along the gastrointestinal tract.

3. The detachable magnetically driven biopsy sampling capsule system according to claim 1, characterized in that: The release rope mechanism includes a first limiting plate and a second limiting plate, both of which are fixed on the magnet, and both of which are provided with through holes for the first connecting rope rod to pass through. When the magnet drives the biopsy sampling needle to move from the initial position to the biopsy sampling position, the release rope mechanism drives the release rope to move from the connection position to the separation position. When the release rope is in the connection position, the first connecting rope rod passes through the first limiting plate and the second limiting plate, and the release rope is wrapped around the first connecting rope rod and is limited between the first limiting plate and the second limiting plate. When the release rope is in the separation position, the first connecting rope rod disengages from at least one of the first limiting plate and the second limiting plate, so that the release rope disengages from the first connecting rope rod, and the first capsule is separated from the second capsule.

4. The detachable magnetically driven biopsy sampling capsule system according to claim 1, characterized in that: The magnet is connected to a return spring. After the biopsy sampling needle completes the biopsy sampling, the return spring drives the magnet to drive the biopsy sampling needle to move from the biopsy sampling position to the initial position.

5. The detachable magnetically driven biopsy sampling capsule system according to claim 1, characterized in that: The traction and removal mechanism includes an external traction rope, a second connecting rope rod is fixed inside the capsule shell, one end of the external traction rope is connected to the second connecting rope rod, and the other end of the external traction rope is located outside the body. After the first capsule is separated from the second capsule, the second capsule is removed from the oral cavity through the external traction rope.

6. The detachable magnetically driven biopsy sampling capsule system according to claim 1, characterized in that: The magnet is detachably connected to the biopsy sampling needle.

7. The detachable magnetically driven biopsy sampling capsule system according to claim 1, characterized in that: The detachable magnetically driven biopsy sampling capsule system further includes an external magnetic control platform, which can drive the first capsule to actively move to the lesion area, and the external magnetic control platform can drive the magnet to drive the biopsy sampling needle to move from an initial position to a biopsy sampling position.

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