Eyelid cleaning solution and wet wipes

Abstract

The present invention relates to an eyelid cleansing liquid and wet wipes. The concentrate for eyelid cleansing comprises, by weight, 0.2-2 parts of a terpene compound, 0.1-5 parts of a flavanol derivative, 0.01-5 parts of a flavonoid compound, and 0.1-5 parts of a natural polysaccharide compound. The eyelid cleansing liquid containing the concentrate has the beneficial effect of providing excellent cleaning effects, combining mite removal, anti-inflammatory, anti-irritation, and anti-allergic functions, and can provide users with a convenient, safe, and efficient eyelid cleansing product, thus facilitating its widespread use.

Description

Technical Field

[0001] The present invention relates to the technical field of eye cleaning, in particular to an eyelid cleaning solution and wet wipes. Background Art

[0002] The eyelids are an important part of the eye, containing eyelashes, meibomian glands, and tear glands. The eyelids are important for overall eye health and can protect the eyes from dangers such as pollen, dust particles, or other foreign matter. The tear film layer produced by the tear glands is essential for eye health. When you blink, a layer of tear film is produced, and the tears are distributed on the cornea to lubricate the surface of the eye. The blinking action also "flushes" foreign matter from the eye. However, due to environmental factors, personal hygiene habits, and factors such as mites, the eyelids can be susceptible to various problems. For example, mite infestations can cause eyelid inflammation and discomfort, and allergic reactions to the eyes may cause symptoms such as swelling, itching, and redness. Seasonal allergies can also cause redness, itching, and inflammation of the eyes and eyelids. Therefore, eyelid cleanliness is essential for eye health.

[0003] Currently, products for eyelid cleansing have problems such as limited cleaning effect, single function, and easy to cause allergic reactions, which are not conducive to improving eyelid health. Summary of the Invention

[0004] (1) Technical issues to be resolved

[0005] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides an eyelid cleaning liquid and wet wipes, which solve the technical problems of current eyelid cleaning products such as limited cleaning effect, single function, and easy to cause allergic reactions.

[0006] (2) Technical solution

[0007] In order to achieve the above objectives, the main technical solutions adopted by the present invention include:

[0008] In a first aspect, an embodiment of the present invention provides a concentrate for eyelid cleaning, comprising, by weight: 0.2-2 parts of a terpene compound, 0.1-5 parts of a flavanol derivative, 0.01-5 parts of a flavonoid compound, and 0.01-5 parts of a natural polysaccharide compound.

[0009] In a second aspect, an embodiment of the present invention provides an eyelid cleansing liquid comprising the concentrate described in the first aspect, deionized water, and a surfactant; the total weight fraction of the concentrate, deionized water, and surfactant is 100 parts, wherein the final mass percentage concentration of the surfactant is 0.1-2%.

[0010] As a preferred embodiment of the present invention, in the eyelid cleansing liquid, the concentrate comprises the following: the terpene compound is a combination of tea tree oil and 4-terpineol; the flavanol derivative is an extract of aloe barbadensis Miller leaves and / or camellia (Camellia ajaponica) extract; the flavonoid compound is one or a combination of two or more selected from the group consisting of tea (Camellia sinensis) extract, citrus (Citrus) extract, purslane (Portulaca oleracea L.) extract, and twisted cactus (Opuntia streptacantha DC.) leaf extract; and the natural polysaccharide compound is one or a combination of two or more selected from the group consisting of oat (Avena sativa L.) bran extract, tamarind (Tamarindus indica) extract, witch hazel (Hamamelis virginiana) extract, dendrobium nobile extract, and honeysuckle (Lonicerajaponica) extract.

[0011] As a preferred embodiment of the present invention, in the eyelid cleansing liquid, the mass ratio of tea tree oil to 4-terpineol in the terpene compound is 1-3:1-5.

[0012] As a preferred embodiment of the present invention, in the eyelid cleansing liquid, the mass ratio of tea tree oil to 4-terpineol in the terpene compound is 1:2, 1:3, 1:4, 1:5, 2:3, 2:5, 3:4 or 3:5.

[0013] As a preferred embodiment of the present invention, the eyelid cleansing solution further includes a skin conditioner and / or an antibacterial compound; the weight portion of the skin conditioner is 0.1-10 parts; the skin conditioner is selected from one or a combination of two or more of panthenol, glycerin, polyglycerol, polyethylene glycol, polypropylene glycol and glycerol fatty acid esters; the weight portion of the antibacterial compound is 0.05-0.1 parts; the antibacterial compound is selected from one or a combination of two or more of 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol and polyaminopropyl biguanide.

[0014] As a preferred embodiment of the present invention, the eyelid cleansing liquid, the surfactant is selected from one or a combination of two or more of polysorbate-20, alkyl dimethyl betaine, alkyl amido betaine, alkyl dimethyl betaine, alkyl amido betaine, alcohol amide, ethoxylated amide, alkylated alcohol, alkyl polyglucoside, amine oxide and sorbitan ester.

[0015] As a preferred embodiment of the present invention, the eyelid cleansing liquid is in the form of a solution, foam, gel, suspension, emulsion or ointment.

[0016] In a third aspect, an embodiment of the present invention provides an eye cleansing wipe comprising the eyelid cleansing solution described in the second aspect.

[0017] (3) Beneficial effects

[0018] The beneficial effects of the present invention are as follows: the eyelid cleansing liquid and wet wipes of the present invention, because the concentrate uses a combination of terpene compounds, flavanol derivatives, flavonoid compounds, and natural polysaccharide compounds, wherein the terpene compounds exert a mite removal effect; and the combination of flavanol derivatives, flavonoid compounds, and natural polysaccharide compounds has a synergistic anti-inflammatory and anti-irritation effect. The eyelid cleansing liquid containing the concentrate simultaneously has excellent mite removal, anti-inflammatory, and anti-irritation effects. While exerting a cleansing effect, it is gentle and non-irritating to the eyes, has a significant anti-allergic effect, and is also suitable for people with sensitive eyes. Compared with the existing technology, the eyelid cleansing liquid containing the concentrate has an excellent cleaning effect, combines mite removal, anti-inflammatory, anti-irritation, and anti-allergic functions, and can provide users with a convenient, safe, and efficient eyelid cleansing product, which is conducive to its promotion and use.

[0019] The terpene compounds in the eyelid cleanser are tea tree oil and 4-terpineol. 4-terpineol is a key ingredient in removing mites. The combination of tea tree oil and 4-terpineol creates a synergistic effect, achieving a 100% mite elimination rate within 48 hours. Tea tree oil, as a natural extract, contains terpinene, α-terpineol, and linalool, which have additional antibacterial and sedative properties. This means that the combination of tea tree oil and 4-terpineol not only removes mites but also synergizes with natural polysaccharides to provide an anti-irritant effect, effectively reducing the occurrence of eye allergies.

[0020] At the same time, the mass ratio of tea tree oil to 4-terpineol is 1-3:1-5. Preferably, the amount of tea tree oil is less than that of 4-terpineol, and the mite removal and anti-irritation effects are best.

[0021] The flavanol derivatives are aloe vera leaf extract and / or camellia extract; the flavonoids are extracts of one or more of tea, citrus, purslane and prickly pear cactus leaves; the natural polysaccharide compounds are extracts of one or more of oat bran, tamarind, witch hazel, dendrobium and honeysuckle; the active ingredients of plant origin are milder and have better anti-allergic effects.

[0022] Eyelid cleansing solution also includes antibacterial compounds, such as 1,2-hexanediol, 1,2-octanediol, and 1,2-decanediol, which have broad-spectrum antibacterial activity; the combination of polyaminopropyl biguanide (PABA) and the above diol compounds can synergistically enhance the antimicrobial effect of eyelid cleansing solution.

[0023] In addition, the eyelid cleansing liquid contains one or a combination of two or more selected from panthenol, glycerin, polyglycerol, polyethylene glycol, polypropylene glycol and glycerol fatty acid ester as skin conditioners, which play the role of moisturizing and conditioning the skin, and assist the effective ingredients of mite removal, anti-inflammatory and anti-irritation to exert their effects.

[0024] The eyelid cleansing solution also includes a surfactant with a final mass percentage concentration of 0.1-2%. The surfactant can provide foaming ability for the eyelid cleansing solution to improve the cleaning ability of the eyelid cleansing solution. The surfactant is particularly suitable for foam formulations. DETAILED DESCRIPTION

[0025] In order to better explain the present invention and facilitate understanding, the present invention is described in detail through specific implementation methods.

[0026] The eyelid cleaning liquid and wet wipes proposed in the embodiments of the present invention address the technical problems of current eyelid cleaning products such as limited cleaning effect, single function, and easy to cause allergic reactions. In the present invention, the concentrate adopts a combination of terpene compounds, flavanol derivatives, flavonoid compounds and natural polysaccharide compounds, among which the terpene compounds play a mite removal effect; the combination of flavanol derivatives, flavonoid compounds and natural polysaccharide compounds has a synergistic anti-inflammatory and anti-irritation effect; the eyelid cleaning liquid containing the concentrate has excellent mite removal, anti-inflammatory and anti-irritation effects, and is gentle and non-irritating to the eyes while playing a cleaning effect, with obvious anti-allergic effect, and is also suitable for people with sensitive eyes. Compared with the existing technology, the eyelid cleaning liquid containing the concentrate has excellent cleaning effect, and integrates the combined functions of mite removal, anti-inflammatory and anti-irritation, and can provide users with a convenient, safe and efficient eyelid cleaning product, which is conducive to promotion and use.

[0027] In order to better understand the above technical solutions, exemplary embodiments of the present invention will be described in more detail below. It should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided to enable a clearer and more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0028] First of all, it should be noted that the plant-derived extracts used in the present invention are all prepared by referring to the extraction methods disclosed in the prior art, and will not be described in detail here.

[0029] Example 1

[0030] This embodiment provides a concentrate for eyelid cleaning, and the specific ingredients and corresponding mass parts are as follows:

[0031]

[0032] The above concentrate for eyelid cleaning is supplemented with deionized water to 100 parts, and then the diluted concentrate is subjected to the following test:

[0033] Referring to the methods in GB 15979-2002 "Hygienic Standard for Disposable Sanitary Products", six microbiological tests (including total bacterial colony count, total fungal colony count, coliform group, Staphylococcus aureus, hemolytic Streptococcus, and Pseudomonas aeruginosa), a skin allergy test, and multiple intact skin irritation tests were performed. The results are shown in Table 1.

[0034] The acute eye irritation test was carried out with reference to the Technical Specifications for Inspection and Disinfection (2002 edition), and the results are shown in Table 1.

[0035] Referring to the test method in NY / T 1151.2-2006, a mite killing rate test was conducted. The results are shown in Table 2.

[0036] Example 2

[0037] This embodiment provides an eyelid cleansing solution, the specific ingredients and corresponding mass fractions are as follows:

[0038]

[0039]

[0040] The relevant testing tests for eyelid cleansing solution are as follows:

[0041] Referring to the methods in GB 15979-2002 "Hygienic Standard for Disposable Sanitary Products", six microbiological tests (including total bacterial colony count, total fungal colony count, coliform group, Staphylococcus aureus, hemolytic Streptococcus, and Pseudomonas aeruginosa), a skin allergy test, and multiple intact skin irritation tests were performed. The results are shown in Table 1.

[0042] The acute eye irritation test was carried out with reference to the Technical Specifications for Inspection and Disinfection (2002 edition), and the results are shown in Table 1.

[0043] Referring to the test method in NY / T 1151.2-2006, a mite killing rate test was conducted. The results are shown in Table 2.

[0044] Referring to the detection methods in Qin Ou, Jiang Wencai, Tan Yimei, et al., Discussion on the evaluation method of the efficacy of cleaning cosmetics [J]. Chinese Journal of Aesthetic Medicine, 2018, 27(06): 64-67; Liu Hongyan, Bi Yongxian, Qian Shumin, et al., and a method for evaluating the cleansing power of cleaning cosmetics [J]. Daily Chemicals Science, 2019, 42(11): 14-17 and the skin oil level detection method in the prior art, the skin oil removal effect evaluation test was carried out. After 5 minutes of use, the results are shown in Table 2.

[0045] Thirty patients with allergic conjunctivitis (with ocular signs) were enrolled and tested for allergy marker IgE. The specific procedure was as follows: Allergy marker IgE testing was performed on the subjects before use, serving as control data. Then, the subjects wiped their eyes with wipes prepared with eyelid cleansing solution 2-3 times daily for 3 months. Finally, tear IgE testing was performed on the subjects. The test results are shown in Table 2. Additionally, signs of ocular inflammation (stinging, conjunctival edema, itching, etc.) were scored before and after enrollment. Stinging, conjunctival edema, and itching were each scored from 0 to 3 points. A sum of scores > 5 indicated significant improvement, and 3 > x > 5 indicated mild improvement. The statistical results are shown in Table 2.

[0046] Example 3

[0047] This embodiment provides an eyelid cleansing liquid. The difference between this embodiment and Example 2 is that: 4-terpineol: 0.5 parts; tea tree oil: 0.1 parts; the relevant test results of the eyelid cleansing liquid are shown in Tables 1 and 2.

[0048] Example 4

[0049] This embodiment provides an eyelid cleansing liquid. The difference between this embodiment and Example 2 is that: 4-terpineol: 0.4 parts; tea tree oil: 0.3 parts; related test results of the eyelid cleansing liquid are shown in Tables 1 and 2.

[0050] Example 5

[0051] This embodiment provides an eyelid cleansing liquid. The difference between this embodiment and Example 2 is that: Aloe barbadensis leaf juice: 0.01 parts; Oat bran extract: 0.01 parts; Portulaca oleracea extract: 0.05 parts; Opuntia contorta leaf extract: 0.05 parts; the relevant test results of the eyelid cleansing liquid are shown in Tables 1 and 2.

[0052] Example 6

[0053] This embodiment provides an eyelid cleansing liquid. The difference between this embodiment and Example 2 is that: Aloe barbadensis leaf juice: 0.05 parts; Oat bran extract: 0.05 parts; Portulaca oleracea extract: 0.1 parts; Opuntia contorta leaf extract: 0.1 parts; the relevant test results of the eyelid cleansing liquid are shown in Tables 1 and 2.

[0054] Example 7

[0055] This embodiment provides an eyelid cleansing liquid. The difference between this embodiment and Example 6 is that: Portulaca oleracea extract: 0.05 parts; Opuntia contorta leaf extract: 0.05 parts; the relevant test results of the eyelid cleansing liquid are shown in Tables 1 and 2.

[0056] Example 8

[0057] This embodiment provides an eyelid cleansing liquid. The difference between this embodiment and Example 6 is that: Aloe barbadensis leaf juice: 0.01 parts; related test results of the eyelid cleansing liquid are shown in Tables 1 and 2.

[0058] Example 9

[0059] This embodiment provides an eyelid cleansing liquid. The difference between this embodiment and Example 2 is that: oat bran extract: 0.01 parts; related test results of the eyelid cleansing liquid are shown in Tables 1 and 2.

[0060] Comparative Example 1

[0061] This comparative example differs from Example 2 in that no tea tree oil is added, and 0.06 parts of 4-terpineol (i.e., 30% of the mass of the tea tree oil in Example 1) are additionally added. The relevant test results of the eyelid cleansing solution are shown in Tables 1 and 2.

[0062] Comparative Example 2

[0063] The difference between this comparative example and Example 2 is that: 0.01 parts of purslane extract and 0.01 parts of opuntia spinulosa leaf extract are used; the relevant test results of the eyelid cleansing solution are shown in Tables 1 and 2.

[0064] Comparative Example 3

[0065] This comparative example differs from Example 2 in that aloe vera leaf juice is not added; the relevant test results of the eyelid cleansing solution are shown in Tables 1 and 2.

[0066] Comparative Example 4

[0067] This comparative example differs from Example 2 in that oat bran extract is not added; the relevant test results of the eyelid cleansing solution are shown in Tables 1 and 2.

[0068] Referring to Table 1 and Table 2, the above examples and comparative examples are analyzed as follows:

[0069] Example 2, a preferred embodiment of an eyelid cleanser, passed six microbial tests. The results of the skin allergy test, multiple intact skin irritation test, and acute eye irritation test, as shown in Table 1, all showed a reaction score of 0, indicating that the eyelid cleanser was non-irritating to the test animals.

[0070] In addition, in this embodiment, the mass ratio of 4-terpineol to tea tree oil was 3:2, and the dual mite removal effect was the best, with a mite removal rate of 100% in 48 hours. After 5 minutes, the average improvement in oil content was as high as 88.0%.

[0071] The significance of tear IgE testing is to more directly understand the local allergic status of the eye. The tear IgE test results in this example show that after using the eyelid cleanser, the tear IgE of up to 90% of patients decreased significantly. As an eyelid cleanser for eye cleaning, it effectively relieved the allergic symptoms of the subjects and had a significant anti-allergic effect.

[0072] The improvement effect on signs related to eye inflammation was the best, with 93% of the subjects showing significant improvement, and the improvement effect on eye inflammation was significant.

[0073] Comparing Examples 3 and 4 with Example 2, it can be seen that increasing or decreasing the amount of tea tree oil reduces the mite removal rate. Simultaneously, the relief of allergic symptoms in the subjects also decreases. This demonstrates that an appropriate amount of tea tree oil can enhance the anti-allergic properties of eyelid cleansing solutions.

[0074] Comparison of Examples 5 and 6 with Example 2 shows that increasing or decreasing the dosage of flavanol derivatives (Aloe barbadensis leaf juice) and flavonoids (Portulaca oleracea extract and Opuntia contorta leaf extract) compared with Example 2 will relatively affect the improvement effect of eye inflammation.

[0075] Comparison of Examples 7 and 8 with Example 6 shows that reducing the dosage of either flavanol derivatives (Aloe barbadensis leaf juice) or flavonoids (Portulaca oleracea extract and Opuntia contorta leaf extract) will relatively affect the improvement effect of ocular inflammation. That is, the dosage ratio of flavanol derivatives and flavonoids in Example 2 has a synergistic effect in improving ocular inflammation.

[0076] Comparison of Example 9 with Example 2 shows that reducing the dosage of oat bran extract significantly reduces the relief of allergic symptoms in the subjects.

[0077] Comparison of Comparative Example 1 with Example 2 shows that without the addition of tea tree oil, the mite removal effect was significantly reduced, with a 48-hour mite removal rate of only 79%. The number of patients with significantly decreased tear IgE levels decreased significantly, and the improvement effect on signs of ocular inflammation was significantly reduced.

[0078] Comparison of Comparative Examples 2 and 3 with Example 2 reveals that insufficient amounts of flavonoids or the absence of flavanol derivatives significantly reduced the effect of improving ocular inflammation and effectively alleviating allergic symptoms in subjects. This suggests that flavonoids and flavanol derivatives have a synergistic effect in improving ocular inflammation and effectively alleviating allergic symptoms in subjects.

[0079] Comparison of Comparative Example 4 with Example 2 shows that without adding oat bran extract, in the initial skin irritation test, the skin irritation test reaction score was 1, and erythema appeared in the rabbits, indicating that oat bran extract plays an important role in anti-allergy.

[0080] Table 1

[0081]

[0082]

[0083] Table 2

[0084]

[0085]

[0086] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the above embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An eyelid cleaning solution, characterized in that: Includes concentrate, deionized water, and surfactant; The total weight of the eyelid cleaning solution is 100 parts, wherein the final mass percentage concentration of the surfactant is 0.1-2%; The concentrate comprises, by weight: 0.3 parts of 4-terpineol, 0.2 parts of tea tree oil, 0.025 parts of aloe vera leaf juice, 0.075 parts of purslane extract, 0.075 parts of prickly pear cactus leaf extract, and 0.025 parts of oat bran extract; Alternatively, 0.5 parts of 4-terpineol, 0.1 parts of tea tree oil, 0.025 parts of aloe barbadensis leaf juice, 0.075 parts of purslane extract, 0.075 parts of opuntia coccinella leaf extract, and 0.025 parts of oat bran extract; Alternatively, 0.4 parts of 4-terpineol, 0.3 parts of tea tree oil, 0.025 parts of aloe barbadensis leaf juice, 0.075 parts of purslane extract, 0.075 parts of opuntia coccinella leaf extract, and 0.025 parts of oat bran extract; Alternatively, 0.3 parts of 4-terpineol, 0.2 parts of tea tree oil, 0.01 parts of aloe barbadensis leaf juice, 0.05 parts of purslane extract, 0.05 parts of opuntia coccinella leaf extract, and 0.01 parts of oat bran extract; Alternatively, 0.3 parts of 4-terpineol, 0.2 parts of tea tree oil, 0.05 parts of aloe barbadensis leaf juice, 0.1 parts of purslane extract, 0.1 parts of opuntia coccinella leaf extract, and 0.05 parts of oat bran extract; Alternatively, 0.3 parts of 4-terpineol, 0.2 parts of tea tree oil, 0.05 parts of aloe barbadensis leaf juice, 0.05 parts of purslane extract, 0.05 parts of opuntia coccinella leaf extract, and 0.05 parts of oat bran extract; Alternatively, 0.3 parts of 4-terpineol, 0.2 parts of tea tree oil, 0.01 parts of aloe barbadensis leaf juice, 0.1 parts of purslane extract, 0.1 parts of opuntia coccinella leaf extract, and 0.05 parts of oat bran extract; Alternatively, 0.3 parts of 4-terpineol, 0.2 parts of tea tree oil, 0.025 parts of aloe barbadensis leaf juice, 0.075 parts of purslane extract, 0.075 parts of opuntia coccinella leaf extract, and 0.01 parts of oat bran extract.

2. The eyelid cleaning solution according to claim 1, wherein Also included are skin conditioning agents and / or antimicrobial compounds; The weight percentage of the skin conditioning agent is 0.1-10 parts; The skin conditioning agent is selected from one or a combination of two or more of panthenol, glycerin, polyglycerin, polyethylene glycol, polypropylene glycol and glycerol fatty acid ester; The weight percentage of the antibacterial compound is 0.05-0.1 parts; The antibacterial compound is selected from one or a combination of two or more of 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol and polyaminopropyl biguanide.

3. The eyelid cleaning solution according to claim 2, wherein The surfactant is selected from one or a combination of two or more of polysorbate-20, alkyl dimethyl betaine, alkyl amido betaine, alcohol amide, ethoxylated amide, alkylated alcohol, alkyl polyglucoside, amine oxide and sorbitan ester.

4. The eyelid cleaning solution according to claim 1, wherein The cleaning solution is in the form of solution, foam, gel, suspension, emulsion or ointment.

5. An eye cleansing wipe, characterized in that: The eyelid cleaning solution comprises the eyelid cleaning solution according to any one of claims 1 to 3.

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