A lipid-lowering composition containing lotus rhizome extract and preparation method thereof

Abstract

The invention discloses a lipid-lowering composition containing lotus rhizome extract and a preparation method thereof, belonging to the technical field of lipid-lowering, the lipid-lowering composition containing lotus rhizome extract comprises, by weight, 2-5 parts of lotus root extract, 1-3 parts of lotus leaf extract, 3-5 parts of lotus seed embryo extract, 1-2 parts of verbascosa ethanol extract, 2-3 parts of rhodiola rosea root extract, 1-2 parts of resveratrol, 1-2 parts of pueraria root flavonoids, 2-3 parts of safflower ethanol extract, and 15-30 parts of beta-cyclodextrin; the beta-cyclodextrin is used as an inclusion material, and lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, and pueraria root flavonoids are used as contents, and the beta-cyclodextrin includes the contents. The lipid-lowering composition containing lotus rhizome extract of the present invention has a better lipid-lowering effect, is taken from natural products, and has no adverse reactions.

Description

Technical Field

[0001] The invention relates to the technical field of reducing blood lipids, in particular to a blood lipid reducing composition containing lotus rhizome extract and a preparation method thereof. Background Art

[0002] Lotus (Nelumbo nucifera Gaertn.) is a perennial aquatic dicotyledonous herb of the Nelumbo family. It is grown in large quantities in Hubei, Jiangsu, Anhui, Jiangxi, Hunan, Zhejiang and other regions in China. Studies have shown that different parts of lotus contain a large number of bioactive ingredients, including polyphenols, alkaloids, polysaccharides, dietary fiber, vitamins, amino acids and various trace elements. The bioactive ingredients extracted from lotus contain a variety of physiological functions of lotus rhizome extracts, such as anti-inflammatory, antioxidant, anti-aging, anti-tumor, hypoglycemic, hypolipidemic, weight loss, liver protection, kidney protection, sleep promotion, immune regulation, treatment of Alzheimer's disease, anti-virus, relief of depression, etc.

[0003] High blood lipids include high triglycerides, high low-density cholesterol, and low high-density cholesterol in the body. Therefore, drugs mainly reduce blood lipids by improving the content of the above three components in the blood, including: reducing low-density lipoprotein (LDL), which increases the risk of heart disease; reducing triglycerides, which is also a type of fat in the blood, which also increases the risk of heart disease; increasing high-density lipoprotein content (HDL), which can protect the heart. Commonly used lipid-lowering drugs include statins, fibrates, bile acid binding resins, cholesterol absorption inhibitors, and niacin. However, the above lipid-lowering drugs each have advantages and disadvantages in terms of therapeutic effects and have side effects. For this reason, the present application proposes a lipid-lowering composition containing lotus rhizome extract. Summary of the invention

[0004] In order to overcome the deficiencies of the prior art, one of the objects of the present invention is to provide a lipid-lowering composition containing lotus rhizome extract, the lipid-lowering composition containing lotus rhizome extract has better lipid-lowering effect, is taken from natural products, and has no adverse reactions.

[0005] The second object of the present invention is to provide a method for preparing a lipid-lowering composition containing lotus rhizome extract, which has simple preparation and low cost.

[0006] The third object of the present invention is to provide a lipid-lowering composition containing lotus rhizome extract for use in the preparation of lipid-lowering health products or medicines.

[0007] One of the purposes of the present invention is achieved by the following technical solution:

[0008] A lipid-lowering composition containing lotus rhizome extract and a preparation method thereof, comprising, by weight, 2-5 parts of lotus root extract, 1-3 parts of lotus leaf extract, 3-5 parts of lotus seed embryo extract, 1-2 parts of verbascosum ethanol extract, 2-3 parts of rhodiola rosea root extract, 1-2 parts of resveratrol, 1-2 parts of kudzu root flavonoids, 2-3 parts of safflower ethanol extract, and 15-30 parts of β-cyclodextrin;

[0009] The beta-cyclodextrin is used as the inclusion material, and lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol and pueraria flavonoids are used as contents, and the beta-cyclodextrin includes the contents.

[0010] Furthermore, based on weight, it includes 3 parts of lotus root extract, 2 parts of lotus leaf extract, 5 parts of lotus seed embryo extract, 2 parts of verbascosum ethanol extract, 3 parts of Rhodiola rosea root extract, 1 part of resveratrol, 1 part of kudzu flavonoids, and 25 parts of β-cyclodextrin.

[0011] Furthermore, according to weight, it includes 2 parts of lotus root extract, 3 parts of lotus leaf extract, 4 parts of lotus seed embryo extract, 1 part of verbascosa ethanol extract, 2 parts of rhodiola rosea root extract, 2 parts of resveratrol, 2 parts of pueraria flavonoids, and 20 parts of β-cyclodextrin.

[0012] Furthermore, based on weight, 1 to 2 parts of compound astragalus and salvia miltiorrhiza extract are included.

[0013] Furthermore, the lipid-lowering composition containing the lotus rhizome extract is in the form of a solution, an emulsion, a suspension, an injection, a powder, a granule, a tablet, or a pill.

[0014] Furthermore, the lotus root extract is extracted from lotus root pulp, lotus root peel and lotus root nodes.

[0015] The second object of the present invention is achieved by adopting the following technical solution:

[0016] A method for preparing a lipid-lowering composition containing lotus rhizome extract comprises the following steps:

[0017] S1. Sieve lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin for later use;

[0018] S2. Weighing raw materials: weighing sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin according to the formula amount;

[0019] S3. Add the sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbabasin ethanol extract, rhodiola rosea root extract, resveratrol, pueraria flavonoids, and safflower ethanol extract to a saturated aqueous solution of β-cyclodextrin, stir evenly, pour into a colloid mill, grind in a colloid mill for 20-30 minutes to obtain a cyclodextrin inclusion complex solution, and freeze-dry to obtain the lipid-lowering composition containing lotus rhizome extract.

[0020] Furthermore, in step S1, the mesh size of the sieve is 80-100 mesh.

[0021] The third object of the present invention is achieved by adopting the following technical solution:

[0022] The invention discloses an application of a lipid-lowering composition containing lotus rhizome extract in preparing a lipid-lowering health product or medicine.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] The invention provides a lipid-lowering composition containing lotus rhizome extract. Lotus root pulp, lotus root peel, lotus root node, lotus seed and lotus leaf are rich in polyphenols, and lotus seed has a high alkaloid content. Polyphenols can reduce blood lipid levels by inhibiting liver lipogenesis factors such as PPAR-γ, GLUT4 and leptin; total alkaloids can inhibit lipase, make lipase partially lose its decomposition ability, and restrict fat from entering the blood, thereby producing a lipid-lowering effect. Therefore, adding lotus root extract, lotus leaf extract and lotus seed embryo extract can effectively reduce blood lipid levels; polyphenols can also improve intestinal flora, inhibit inflammatory response induced by intestinal flora disorder, and promote the generation of brown fat cells in the liver and increase the level of thermogenic genes by inhibiting the miR-335 signaling pathway mediated by TLR4 / TNF-α; rhodiola rosea root extract contains salidroside, which can induce cAMP signal transduction through the COX2 / PGE2 signaling pathway, then upregulate p-CREB, promote browning of fat cells, and reverse the inhibition of browning of fat cells induced by IL-1β; resveratrol can activate Si The rt1 / AMPK / PGC1α / PPARα signaling pathway reverses the inhibition of adipocyte browning induced by LPS-TLR4 signaling; the ethanol extract of Mullein contains the lotus rhizome extract that inhibits the activity of plasminogen activator inhibitor-1 (PAI-1), and the compound Astragalus and Salvia miltiorrhiza extract can reduce the transcription level of plasminogen activator inhibitor-1 (PAI-1) mRNA; in addition to reducing the content of low-density lipoprotein cholesterol, Pueraria lobata flavonoids can also promote the synthesis of high-density lipoprotein cholesterol, help clear garbage and toxins in blood vessels, and maintain normal blood lipid levels; and safflower ethanol extract can reduce the content of triglycerides; the inclusion effect of β-cyclodextrin helps to improve the absorption of polyphenols and alkaloids in the small intestine, increase bioavailability, and give full play to its lipid-lowering effect. It can be seen that the above components enhance the lipid-lowering effect from different pathways of action, and the therapeutic effect is further improved. DETAILED DESCRIPTION

[0025] The present invention is further described below in conjunction with specific embodiments. It should be noted that, under the premise of no conflict, the embodiments or technical features described below can be arbitrarily combined to form a new embodiment.

[0026] Verbascum ethanol extract and pueraria flavonoids were purchased from Fufeng Snort Biotechnology Co., Ltd.;

[0027] Rhodiola rosea root extract was purchased from Changsha Shanghe Biotechnology Co., Ltd.;

[0028] Resveratrol was purchased from Shanghai MacLean Biochemical Technology Co., Ltd.;

[0029] Safflower ethanol extract salty was purchased from Yang Kelun Bioengineering Co., Ltd.;

[0030] Compound Astragalus and Salvia miltiorrhiza extracts were purchased from Shaanxi Jiahe Biotechnology Co., Ltd.;

[0031] The lipid four-item combined test kit (enzymatic method) was purchased from Sino Biosensor Co., Ltd.;

[0032] Preparation of lotus root extract: 100 g of dry lotus root was refluxed with 70% (V / V) ethanol aqueous solution for 12 h, and after cooling, it was filtered through filter paper with a pore size of 1.2 μm. The filtered lotus root extract was concentrated under reduced pressure at 50°C and completely dried in a vacuum dryer to obtain 4.5 g of lotus root extract.

[0033] Preparation of lotus seed extract: 100 g of lotus seeds were refluxed with a 70% (V / V) ethanol aqueous solution for 12 h, cooled, and filtered through filter paper with a pore size of 1.2 μm. The filtered lotus seed extract was concentrated under reduced pressure at 50° C. and completely dried using a reduced pressure dryer to obtain 11.12 g of lotus seed extract.

[0034] Preparation of lotus leaf extract: 100 g of dried lotus leaves were heated to reflux with a 70% (V / V) ethanol aqueous solution for 12 h, cooled and filtered through filter paper with a pore size of 1.2 μm. The filtered lotus leaf extract was concentrated under reduced pressure at 50°C and completely dried with a vacuum dryer to obtain 7.54 g of lotus leaf extract.

[0035] Example 1

[0036] The present embodiment provides a lipid-lowering composition containing lotus rhizome extract, which includes, by weight, 3 parts of lotus root extract, 2 parts of lotus leaf extract, 5 parts of lotus seed embryo extract, 2 parts of verbascosum ethanol extract, 3 parts of Rhodiola rosea root extract, 1 part of resveratrol, 1 part of kudzu flavonoids, 3 parts of safflower ethanol extract, and 25 parts of β-cyclodextrin.

[0037] The preparation method comprises the following steps:

[0038] S1. Sieve lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin, with a sieve size of 100 mesh, and set aside;

[0039] S2. Weighing raw materials: weighing sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin according to the formula amount;

[0040] S3. Add the sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbabasin ethanol extract, rhodiola rosea root extract, resveratrol, pueraria flavonoids, and safflower ethanol extract to a saturated aqueous solution of β-cyclodextrin, stir evenly, pour into a colloid mill, and grind in a colloid mill for 20 minutes to obtain a cyclodextrin inclusion complex solution, and freeze-dry to obtain a lipid-lowering composition containing lotus rhizome extract.

[0041] Example 2

[0042] The present embodiment provides a lipid-lowering composition containing lotus rhizome extract, which includes, by weight, 2 parts of lotus root extract, 3 parts of lotus leaf extract, 4 parts of lotus seed embryo extract, 1 part of verbascosum ethanol extract, 2 parts of Rhodiola rosea root extract, 2 parts of resveratrol, 2 parts of kudzu flavonoids, 2 parts of safflower ethanol extract, and 20 parts of β-cyclodextrin.

[0043] The preparation method of the lipid-lowering composition containing lotus rhizome extract in this embodiment comprises the following steps:

[0044] S1. Sieve lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin, with a sieve size of 100 mesh, and set aside;

[0045] S2. Weighing raw materials: weighing sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin according to the formula amount;

[0046] S3. Add the sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbabasin ethanol extract, rhodiola rosea root extract, resveratrol, pueraria flavonoids, and safflower ethanol extract to a saturated aqueous solution of β-cyclodextrin, stir evenly, pour into a colloid mill, and grind in a colloid mill for 30 minutes to obtain a cyclodextrin inclusion complex solution, and freeze-dry to obtain a lipid-lowering composition containing lotus rhizome extract.

[0047] Example 3

[0048] The present embodiment provides a lipid-lowering composition containing lotus rhizome extract, including 5 parts of lotus root extract, 1 part of lotus leaf extract, 3 parts of lotus seed embryo extract, 2 parts of verbascosa ethanol extract, 2 parts of rhodiola rosea root extract, 1 part of resveratrol, 2 parts of kudzu root flavonoids, 3 parts of safflower ethanol extract,

[0049] β-Cyclodextrin 15.

[0050] The preparation method of the lipid-lowering composition containing lotus rhizome extract in this embodiment comprises the following steps:

[0051] S1. Sieve lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin, with a sieve size of 100 mesh, and set aside;

[0052] S2. Weighing raw materials: weighing sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin according to the formula amount;

[0053] S3. Add the sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbabasin ethanol extract, rhodiola rosea root extract, resveratrol, pueraria flavonoids, and safflower ethanol extract to a saturated aqueous solution of β-cyclodextrin, stir evenly, pour into a colloid mill, grind in a colloid mill for 25 minutes to obtain a cyclodextrin inclusion complex solution, and freeze-dry to obtain a lipid-lowering composition containing lotus rhizome extract.

[0054] Example 4

[0055] The present embodiment provides a lipid-lowering composition containing lotus rhizome extract, including 3 parts of lotus root extract, 2 parts of lotus leaf extract, 5 parts of lotus seed embryo extract, 2 parts of verbascosum ethanol extract, 3 parts of Rhodiola rosea root extract, 1 part of resveratrol, 1 part of Pueraria lobata flavonoids, 25 parts of β-cyclodextrin, 1 part of compound Astragalus and Salvia miltiorrhiza extract, 3 parts of safflower ethanol extract, and 30 parts of β-cyclodextrin.

[0056] The preparation method of the lipid-lowering composition containing lotus rhizome extract in this embodiment comprises the following steps:

[0057] S1. Sieve lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin, with a sieve size of 100 mesh, and set aside;

[0058] S2. Weighing raw materials: weighing sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin according to the formula amount;

[0059] S3. Add the sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbabasin ethanol extract, rhodiola rosea root extract, resveratrol, pueraria flavonoids, and safflower ethanol extract to a saturated aqueous solution of β-cyclodextrin, stir evenly, pour into a colloid mill, and grind in a colloid mill for 20 minutes to obtain a cyclodextrin inclusion complex solution, and freeze-dry to obtain a lipid-lowering composition containing lotus rhizome extract.

[0060] Example 5

[0061] The present embodiment provides a lipid-lowering composition containing lotus rhizome extract, including 3 parts of lotus root extract, 2 parts of lotus leaf extract, 5 parts of lotus seed embryo extract, 2 parts of verbascosum ethanol extract, 3 parts of Rhodiola rosea root extract, 1 part of resveratrol, 1 part of Pueraria lobata flavonoids, 25 parts of β-cyclodextrin, 2 parts of compound Astragalus and Salvia miltiorrhiza extract, 2 parts of safflower ethanol extract, and 30 parts of β-cyclodextrin.

[0062] The preparation method of the lipid-lowering composition containing lotus rhizome extract in this embodiment comprises the following steps:

[0063] S1. Sieve lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin, with a sieve size of 100 mesh, and set aside;

[0064] S2. Weighing raw materials: weighing sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin according to the formula amount;

[0065] S3. Add the sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbabasin ethanol extract, rhodiola rosea root extract, resveratrol, pueraria flavonoids, and safflower ethanol extract to a saturated aqueous solution of β-cyclodextrin, stir evenly, pour into a colloid mill, grind in a colloid mill for 25 minutes to obtain a cyclodextrin inclusion complex solution, and freeze-dry to obtain a lipid-lowering composition containing lotus rhizome extract.

[0066] Comparative Example 1

[0067] Different from Example 1, this comparative example provides a lipid-lowering composition containing lotus rhizome extract, which includes, by weight, 3 parts of lotus root extract, 2 parts of lotus leaf extract, 5 parts of lotus seed embryo extract, 3 parts of Rhodiola rosea root extract, 1 part of resveratrol, 1 part of Pueraria lobata flavonoids, 3 parts of safflower ethanol extract, and 25 parts of β-cyclodextrin.

[0068] Comparative Example 2

[0069] Different from Example 1, this comparative example provides a lipid-lowering composition containing lotus rhizome extract, which includes 3 parts of lotus root extract, 2 parts of lotus leaf extract, 5 parts of lotus seed embryo extract, 3 parts of Rhodiola rosea root extract, 1 part of Pueraria lobata flavonoids, 3 parts of safflower ethanol extract, and 25 parts of β-cyclodextrin in parts by weight.

[0070] Comparative Example 3

[0071] Different from Example 1, this comparative example provides a lipid-lowering composition containing lotus rhizome extract, which includes 3 parts of lotus root extract, 2 parts of lotus leaf extract, 5 parts of lotus seed embryo extract, 1 part of Pueraria lobata flavonoids, 3 parts of safflower ethanol extract, and 25 parts of β-cyclodextrin in parts by weight.

[0072] Experimental example

[0073] 6-week-old BALB / c mice were purchased from the Experimental Animal Center of Guangdong Medical University. The mice were individually placed in plastic cages with room temperature controlled at 24°C and subjected to a 12-hour light-dark cycle. The experimental operation was carried out in accordance with the guidelines provided by the University Experimental Animal Ethics Management Committee. 80 BALB / c mice were randomly divided into 8 groups, 10 in each group: normal control group, high-fat model control group, Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group. The normal control group was fed with a basic feed, and the remaining groups were fed with a high-fat feed to establish a high-fat model. After the high-fat model was successfully established, the BALB / c mice in Example 1 group, Example 2 group, Example 3 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group were gavaged with a lipid-lowering composition containing lotus rhizome extract prepared by each group every day. According to the weight of the mice, the gavage dose was 800 mg / Kg, and the gavage volume was 0.3 mL. The BALB / c mice in the normal control group and the high-fat model control group were gavaged with an equal amount of physiological saline.

[0074] Detection indicators: (1) After 15 days, the mice were fasted overnight (24 h). The next day, they were killed by cardiac bleeding under pentobarbital sodium anesthesia. Serum was separated from the blood and the values ​​of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) blood lipid four-item combined detection kit (enzymatic method) were used to detect the values. The absorbance values ​​of total cholesterol and triglycerides were detected at 510 nm on an ELISA reader, and the absorbance values ​​of high-density lipoprotein and low-density lipoprotein were detected at 546 nm. The values ​​of total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein of the mice were calculated according to the formula of the kit. The results are shown in Table 1.

[0075] Table 1 Results of four blood lipid tests

[0076]

[0077] As shown in Table 1, the total cholesterol (TC) level of the serum of the mice in the high-fat model control group is higher than that of the mice in the normal group, indicating that the high cholesterol model of the mice has been established. Compared with the mice in the high-fat model control group, the total cholesterol level of the mice in the embodiment 1 group, the embodiment 2 group, the embodiment 3 group, the comparative example 1 group, the comparative example 2 group, and the comparative example 3 group can all reduce the total cholesterol level of the mice in the high-fat model control group, reduce the level of low-density lipoprotein (LDL-C), and increase the level of high-density lipoprotein (HDL-C), indicating that the embodiment 1 group, the embodiment 2 group, the embodiment 3 group, the comparative example 1 group, the comparative example 2 group, and the comparative example 3 group all have the therapeutic effect of reducing blood lipids, and the effect of the embodiment 1 group is better than that of the comparative example 1 group, the comparative example 2 group, and the comparative example 3 group, indicating that the components of the present invention strengthen the lowering effect of blood lipids from different pathways of action, and the therapeutic effect is further improved.

[0078] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A lipid-lowering composition containing lotus rhizome extract, characterized in that: The raw materials are composed of 2 to 5 parts of lotus root extract, 1 to 3 parts of lotus leaf extract, 3 to 5 parts of lotus seed embryo extract, 1 to 2 parts of verbascosa ethanol extract, 2 to 3 parts of rhodiola rosea root extract, 1 to 2 parts of resveratrol, 1 to 2 parts of kudzu root flavonoids, 2 to 3 parts of safflower ethanol extract and 15 to 30 parts of β-cyclodextrin. The β-cyclodextrin is used as an inclusion material, and lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, and safflower ethanol extract are used as contents, and the β-cyclodextrin includes the contents; The lotus root extract, lotus seed embryo extract and lotus leaf extract are lotus root 70% ethanol extract, lotus seed embryo 70% ethanol extract and lotus leaf 70% ethanol extract respectively.

2. The lipid-lowering composition containing lotus rhizome extract according to claim 1, characterized in that: The raw material composition is as follows by weight: 3 parts of lotus root extract, 2 parts of lotus leaf extract, 5 parts of lotus seed embryo extract, 2 parts of verbascosa ethanol extract, 3 parts of Rhodiola rosea root extract, 1 part of resveratrol, 1 part of kudzu flavonoids, 3 parts of safflower ethanol extract and 25 parts of β-cyclodextrin.

3. The lipid-lowering composition containing lotus rhizome extract according to claim 1, characterized in that: The raw materials are composed of 2 parts of lotus root extract, 3 parts of lotus leaf extract, 4 parts of lotus seed embryo extract, 1 part of verbascosa ethanol extract, 2 parts of Rhodiola rosea root extract, 2 parts of resveratrol, 2 parts of Pueraria lobata flavonoids, 2 parts of safflower ethanol extract and 20 parts of β-cyclodextrin.

4. The lipid-lowering composition containing lotus rhizome extract according to claim 1, characterized in that: A pharmaceutically acceptable excipient is further added, and the excipient is one of an excipient, a disintegrant, a sweetener, a binder, a coating agent and a bulking agent.

5. The lipid-lowering composition containing lotus rhizome extract according to claim 1, characterized in that: The preparation of the lipid-lowering composition containing the lotus rhizome extract is one of a solution, an emulsion, a suspension, an injection, a powder, a granule, a tablet, and a pill.

6. A lipid-lowering composition containing lotus rhizome extract, characterized in that: On the basis of the lipid-lowering composition containing lotus rhizome extract as claimed in claim 1, 1 to 2 parts by weight of compound astragalus and salvia miltiorrhiza extract is further added.

7. A method for preparing a lipid-lowering composition containing lotus rhizome extract according to any one of claims 1 to 3, characterized in that: The following steps are involved: S1. Sieve lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin for later use; S2. Weighing raw materials: weighing sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbascosa ethanol extract, rhodiola rosea root extract, resveratrol, kudzu root flavonoids, safflower ethanol extract, and β-cyclodextrin according to the formula amount; S3. Add the sieved lotus root extract, lotus leaf extract, lotus seed embryo extract, verbabasin ethanol extract, rhodiola rosea root extract, resveratrol, pueraria flavonoids, and safflower ethanol extract to a saturated aqueous solution of β-cyclodextrin, stir evenly, pour into a colloid mill, grind in a colloid mill for 20-30 minutes to obtain a cyclodextrin inclusion complex solution, and freeze-dry to obtain the lipid-lowering composition containing lotus rhizome extract.

8. The method for preparing a lipid-lowering composition containing lotus rhizome extract according to claim 7, characterized in that: In step S1, the mesh size of the sieve is 80-100 mesh.

9. Use of a lipid-lowering composition containing lotus rhizome extract according to any one of claims 1 to 6 in the preparation of a lipid-lowering health product or medicine.

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