A heparin sodium precipitation and separation device

Abstract

The present invention provides a sodium heparin precipitation and separation device, which relates to the technical field of sediment separation equipment, including: a bottom plate, a support frame, a distribution box, a control panel, a mixing tube box, a liquid infusion tube box, a sedimentation box, a rising flow tube box, a reflux tube box, a resonance frame and a right-angle conversion frame; the left and right ends of the top of the bottom plate are respectively connected upwardly with a cylindrical mixing tube box by a support frame welded by square tubes; one end of the mixing tube box is fixedly provided with a servo motor, and the mixing tube box at the end where the servo motor is located is vertically connected to the liquid infusion tube box, and the other end of the mixing tube box is vertically connected to the rising flow tube box. The sodium heparin precipitation and separation device proposed by the present invention realizes efficient precipitation and separation of the sodium heparin mixed solution through the steps of mixing, precipitation, rising flow and reflux, combined with the resonance effect of the resonance frame. The device has a simple structure and is easy to operate. It is suitable for the sodium heparin precipitation and separation process in large-scale production, and improves production efficiency and quality.

Description

Technical Field

[0001] The invention relates to the technical field of precipitate separation equipment, and in particular to a heparin sodium precipitation separation device. Background Art

[0002] As an important anticoagulant drug, heparin sodium has a wide range of applications in the medical field. In the production process, the precipitation and separation of heparin sodium is a key step, and its effect directly affects the quality and production efficiency of the final product. The traditional process of the production of heparin sodium on the market is to place a mixed solution containing heparin components in a plastic container or a cement cavity with a fiberglass inner cavity, and then add alcohol and stir it. Under the action of alcohol, heparin sodium forms a precipitate and separates from the mixed solution. After the reaction is complete, the mixed solution is discharged, and then the heparin sodium is extracted from the reaction container.

[0003] The traditional precipitation and separation method of sodium heparin usually adopts static sedimentation. Although this method is simple to operate, it has problems such as slow precipitation speed, easy adhesion of precipitates to the inner wall of the container, and low separation efficiency. In addition, traditional methods often cannot achieve continuous production, resulting in low production efficiency and cannot meet the needs of large-scale production. Summary of the invention

[0004] The invention relates to a sodium heparin precipitation and separation device, and provides an efficient and continuous sodium heparin precipitation and separation device. By solving the above technical problems, the efficient production and quality improvement of sodium heparin are achieved, and contributions are made to the development of the pharmaceutical industry.

[0005] The invention provides a sodium heparin precipitation and separation device, which specifically comprises: a bottom plate, a support frame, a distribution box, a control panel, a mixing pipe box, a liquid infusion pipe box, a sedimentation box, a riser pipe box, a reflux pipe box, a resonance frame and a right-angle conversion frame; the left and right ends of the top of the bottom plate are respectively connected upwardly with a cylindrical mixing pipe box through a support frame formed by welding square tubes; a servo motor is fixedly arranged at one end of the mixing pipe box, and a liquid infusion pipe box is vertically connected upwardly on the mixing pipe box at the end where the servo motor is located, and a rising pipe box is vertically connected upwardly on the other end of the mixing pipe box; a reflux pipe box is arranged between the rising pipe box and the liquid infusion pipe box, and the left and right ends of the inner cavity of the reflux pipe box are fixedly connected to the rising pipe box. They are respectively connected with the inner cavity of the riser pipe box and the replenishment pipe box; a sedimentation box is vertically provided at one end of the bottom of the mixing pipe box close to the riser pipe box, and the upper end of the inner cavity of the sedimentation box is connected with the inner cavity of the mixing pipe box; a right-angle conversion frame is fixedly provided at the connection point between the inner cavity of the mixing pipe box and the bottom of the inner cavity of the riser pipe box, and the two ends of the right-angle conversion frame are respectively rotatably connected with the first bevel gear and the second bevel gear through a rotating shaft; a distribution box is fixedly installed on the top plane of the bottom plate; a control panel is fixedly mounted on the supporting frame under the replenishment pipe box; the end of the sedimentation box close to the replenishment pipe box is an inclined structure inclined downward, and a resonance frame is fixedly installed on the inclined end of the sedimentation box along the inclined direction.

[0006] Optionally, a conveying mixing shaft is rotatably installed in the middle of the inner cavity of the mixing tube box, one end of the conveying mixing shaft is fixedly connected to the rotating shaft of the servo motor through a coupling, and the other end of the conveying mixing shaft is fixedly connected to the second bevel gear on the right-angle conversion frame;

[0007] The conveying mixing shaft is fixedly installed with a first-stage mixing spiral auger and a second-stage mixing spiral auger, the first-stage mixing spiral auger and the second-stage mixing spiral auger are fixedly connected to each other, the first-stage mixing spiral auger is close to the liquid infusion pipe box, and the second-stage mixing spiral auger corresponds to the upper part of the inner cavity of the sedimentation box, and the pitch of the first-stage mixing spiral auger is smaller than the pitch of the second-stage mixing spiral auger;

[0008] A fan-shaped conveying impeller is fixedly connected to the end of the second-stage mixing spiral auger near the riser box.

[0009] Optionally, a heparin sodium mixture inlet tube and an alcohol inlet tube are respectively vertically connected to the outer side wall of the upper end of the infusion tube box, and solenoid valves are installed on the heparin sodium mixture inlet tube and the alcohol inlet tube;

[0010] A liquid level sensor is installed at a position of the liquid replenishment pipe box close to the reflux pipe box.

[0011] Optionally, the inner cavity of the inclined end of the sedimentation box is a concave structure, the bottom of the inner cavity of the sedimentation box is a diversion oblique block inclined toward the inclined end of the sedimentation box, a sediment extraction pipe is vertically connected downward to the bottom plate of the inner cavity of the sedimentation box on one side of the diversion oblique block, and an extraction pump is installed on the sediment extraction pipe;

[0012] A first viewing window is vertically embedded in the side wall of the sedimentation box;

[0013] A viscosity detection sensor is provided at a position near the bottom of the inner cavity of the sedimentation box.

[0014] Optionally, the lower end of the upflow pipe box is a 90-degree bent pipe structure connected to the sedimentation box, and an upflow shaft is provided in the middle of the upflow pipe box for vertical rotation. The lower end of the upflow shaft is fixedly connected to the first bevel gear on the right-angle conversion frame, and an upflow wheel and a booster turbine are fixedly installed on the upflow shaft. The upflow wheel is located below the booster turbine, and the upflow wheel is a fan-blade structure.

[0015] Optionally, the end of the return pipe box connected to the riser pipe box is higher than the end of the return pipe box connected to the liquid replenishment pipe box, and the upper end of the liquid replenishment pipe box is higher than the upper end of the riser pipe box;

[0016] A second viewing window is inlaid on the front end side wall of the return pipe box;

[0017] The upper end of the front end side wall of the reflux pipe box close to the riser pipe box is vertically connected to the drain pipe. The drain pipe is a T-shaped three-way structure. One pipe opening of the drain pipe is a discharge pipe opening, on which a solenoid valve is provided, and the other pipe opening is a detection pipe opening, on which a viscosity detector is provided, and the pipe opening is refluxed and connected to the liquid replenishment pipe box (not shown in the figure).

[0018] Optionally, a through rectangular mounting hole is provided in the middle of the resonance frame, and guide rods are fixedly connected to the upper and lower ends of the mounting hole along the resonance frame respectively, and the end of the guide rod is fixedly connected to the resonance frame through a fixing block, and springs are respectively mounted on the two ends of the guide rod, and the opposite ends of the two springs are respectively fixedly connected to cylindrical resonance blocks that are slidably sleeved on the guide rod; the resonance motor is fixedly installed at the upper middle part of the resonance frame.

[0019] The present invention provides a sodium heparin precipitation and separation device, which has the following beneficial effects:

[0020] 1. The sodium heparin precipitation and separation device proposed in the present invention realizes efficient precipitation and separation of the sodium heparin mixed solution through the steps of mixing, precipitation, upflow and reflux, combined with the resonance effect of the resonance frame. The device has a simple structure and is easy to operate. It is suitable for the sodium heparin precipitation and separation process in large-scale production, and improves production efficiency and quality.

[0021] 2. In the present invention, the servo motor can spirally convey the injected sodium heparin mixed liquid and alcohol while driving the conveying mixing shaft to rotate, and fully mix them during the conveying process with the help of spiral rotation, thereby improving the mixing efficiency. The small pitch of the first-stage mixing spiral auger can increase the mixing path and make the mixing more complete. The small pitch of the second-stage mixing spiral auger can reduce the conveying speed, so that the mixed liquid can be retained at a position above the inner cavity of the sedimentation box to facilitate the sedimentation of the sodium heparin precipitate produced therein, and the light mixed liquid can continue to be conveyed to the riser box by the second-stage mixing spiral auger and the conveying impeller, thereby achieving the triple effects of conveying, mixing and sedimentation during the conveying process, effectively improving the production efficiency of sodium heparin, and allowing continuous operation and production.

[0022] 3. In the present invention, the inclined end of the sedimentation box is fixedly installed with a resonance frame along the inclined direction, so that the mixed liquid can be settled when passing through the upper position of the sedimentation box. The sediment slides down along the inclined surface of the inner cavity of the sedimentation box and is collected at the lower end of the sedimentation box. Under the action of the resonance motor on the resonance frame, the sediment adhered to the surface of the sedimentation box will also be shaken off and slide down, thereby effectively reducing the situation where the sediment adheres to the inner cavity surface of the sedimentation box and improving the output rate of sodium heparin.

[0023] 4. The second-stage mixing spiral auger and the conveying impeller of the present invention can also drive the liquid in the inner cavity of the sedimentation box to flow toward the side close to the riser box during rotation, which can help to increase the rapid sedimentation and collection of sediments to the lower end of the sedimentation box and reduce the probability of sediments hanging on the wall.

[0024] 5. The present invention determines whether there is enough sodium heparin precipitate to be discharged from the area through the detection of the viscosity detection sensor. If so, it is extracted through the precipitate extraction tube by the extraction pump. When the viscosity detected by the viscosity detection sensor is lower than the set standard, the extraction pump stops extracting the precipitate, and starts again when there is enough precipitate in the sedimentation box. This reciprocating process can achieve non-stop production, and will not discharge too much light solution, thereby ensuring the output quality of sodium heparin. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solution of the embodiment of the present invention, the drawings of the embodiment are briefly introduced below.

[0026] The drawings described below are only related to some embodiments of the present invention, but are not intended to limit the present invention.

[0027] In the attached picture:

[0028] Figure 1 A schematic diagram of the first axial view of the present invention is shown;

[0029] Figure 2 A second axial structural schematic diagram of the present invention is shown;

[0030] Figure 3 The main structural diagram of the present invention is shown;

[0031] Figure 4 The present invention shows Figure 3 A is a schematic diagram of the structure of the enlarged part;

[0032] Figure 5 It shows a schematic diagram of the axial structure of the mixing pipe box, the settling box, the riser pipe box and the return pipe box in a partially half-cut and separated state;

[0033] Figure 6 It shows a schematic diagram of the axial structure of the sedimentation box of the present invention in a half-cut apart state;

[0034] Figure 7 It shows a schematic diagram of the axial structure of the conveying and mixing shaft, the upflow shaft and the right-angle conversion frame of the present invention;

[0035] Figure 8 The schematic diagram of the axial structure of the cavity state of the mixing pipe box, the settling box, the riser pipe box and the return pipe box of the present invention is shown.

[0036] Reference numerals list

[0037] 1. Bottom plate;

[0038] 2. Support frame;

[0039] 3. Distribution box;

[0040] 4. Control panel;

[0041] 5. Mixing tube box; 501. Servo motor; 502. Conveying mixing shaft; 503. First-stage mixing spiral auger; 504. Second-stage mixing spiral auger; 505. Conveying impeller;

[0042] 6. Fluid infusion tube box; 601. Heparin sodium mixed solution infusion tube; 602. Alcohol infusion tube; 603. Liquid level sensor;

[0043] 7. Sedimentation box; 701. First viewing window; 702. Sediment extraction pipe; 703. Extraction pump; 704. Diversion inclined block; 705. Viscosity detection sensor;

[0044] 8. Rising flow tube box; 801. Rising flow shaft; 802. Rising flow wheel; 803. Booster turbine;

[0045] 9. Reflux pipe box; 901. Second viewing window; 902. Drain pipe;

[0046] 10. resonance frame; 1001. mounting hole; 1002. resonance motor; 1003. guide rod; 1004. spring; 1005. resonance block;

[0047] 11. Right-angle conversion frame; 1101. First bevel gear; 1102. Second bevel gear. DETAILED DESCRIPTION

[0048] In order to make the purpose, technical solution and advantages of the embodiment of the present invention clearer, the technical solution of the embodiment of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiment of the present invention. Obviously, the described embodiment is a part of the embodiment of the present invention, not all of the embodiments. Based on the described embodiment of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0049] Example 1: Please refer to Figures 1 to 8 :

[0050] The present invention proposes a sodium heparin precipitation and separation device, comprising: a bottom plate 1, a support frame 2, a distribution box 3, a control panel 4, a mixing tube box 5, a liquid infusion tube box 6, a sedimentation box 7, a riser tube box 8, a return tube box 9, a resonance frame 10 and a right-angle conversion frame 11; the left and right ends of the top of the bottom plate 1 are respectively connected upwardly with a cylindrical mixing tube box 5 by a support frame 2 formed by welding of square tubes; a servo motor 501 is fixedly arranged at one end of the mixing tube box 5, and a liquid infusion tube box 6 is vertically connected upwardly on the mixing tube box 5 at the end where the servo motor 501 is located, and a riser tube box 8 is vertically connected upwardly on the other end of the mixing tube box 5; a return tube box 9 is arranged between the riser tube box 8 and the liquid infusion tube box 6, and the left and right ends of the inner cavity of the return tube box 9 are respectively connected with the inner cavities of the riser tube box 8 and the liquid infusion tube box 6; a sedimentation box 7 is vertically arranged at one end of the bottom of the mixing tube box 5 close to the riser tube box 8, and the upper end of the inner cavity of the sedimentation box 7 is connected to the inner cavity of the mixing tube box 5 The mixing tube box 5 is connected with the bottom of the inner cavity of the riser tube box 8, and a right-angle conversion frame 11 is fixedly provided at the place where the inner cavity of the mixing tube box 5 is connected with the inner cavity of the riser tube box 8. The two ends of the right-angle conversion frame 11 are respectively connected with the first bevel gear 1101 and the second bevel gear 1102 through the rotating shaft; the distribution box 3 is fixedly installed on the top plane of the bottom plate 1; the control panel 4 is fixedly mounted on the support frame 2 below the infusion tube box 6; the end of the sedimentation box 7 close to the infusion tube box 6 is an inclined structure obliquely downward, and the inclined end of the sedimentation box 7 is fixedly installed with a resonance frame 10 along the inclined direction, so that the mixed liquid can be settled when passing through the upper position of the sedimentation box 7, and the sediment slides down along the inclined surface of the inner cavity of the sedimentation box 7 and is collected at the lower end of the sedimentation box 7. Under the action of the resonance motor 1002 on the resonance frame 10, the sediment adhered to the surface of the sedimentation box 7 will also be shaken off and slide down, thereby effectively reducing the situation where the sediment adheres to the inner cavity surface of the sedimentation box 7, and improving the output rate of sodium heparin.

[0051] The mixing tube box 5 has a conveying and mixing shaft 502 rotatably mounted in the middle of the inner cavity. One end of the conveying and mixing shaft 502 is fixedly connected to the rotating shaft of the servo motor 501 through a coupling, and the other end of the conveying and mixing shaft 502 is fixedly connected to the second bevel gear 1102 on the right-angle conversion frame 11.

[0052] The conveying and mixing shaft 502 is fixedly installed with the first section mixing spiral auger 503 and the second section mixing spiral auger 504, the first section mixing spiral auger 503 and the second section mixing spiral auger 504 are fixedly connected to each other, the first section mixing spiral auger 503 is close to the infusion pipe box 6, the second section mixing spiral auger 504 corresponds to the upper part of the inner cavity of the sedimentation box 7, the pitch of the first section mixing spiral auger 503 is smaller than the pitch of the second section mixing spiral auger 504, the end of the second section mixing spiral auger 504 is fixedly connected with a fan-shaped conveying impeller 505 near the riser pipe box 8, and the servo motor 501 drives the conveying and mixing shaft 502 to rotate, which can mix the injected heparin sodium mixed solution and alcohol. The spiral conveying is used to fully mix the mixture during the conveying process by means of the spiral rotation, thereby improving the mixing efficiency. The small pitch of the first-stage mixing spiral auger 503 can increase the mixing path and make the mixing more complete. The small pitch of the second-stage mixing spiral auger 504 can reduce the conveying speed, so that the mixed liquid can be retained above the inner cavity of the sedimentation box 7, so as to facilitate the sedimentation of the sodium heparin precipitate produced therein, and the light mixed liquid can continue to be conveyed to the riser box 8 by the second-stage mixing spiral auger 504 and the conveying impeller 505, thereby achieving the triple effects of conveying, mixing and sedimentation during the conveying process, effectively improving the production efficiency of sodium heparin, and enabling continuous production.

[0053] The second-stage mixing spiral auger 504 and the conveying impeller 505 can also drive the liquid in the inner cavity of the sedimentation box 7 to flow toward the side close to the riser box 8 during rotation, which can help increase the rapid sedimentation and collection of the sediment to the lower end of the sedimentation box 7 and reduce the probability of the sediment hanging on the wall.

[0054] Among them, a heparin sodium mixture filling tube 601 and an alcohol filling tube 602 are respectively vertically connected to the outer wall of the upper end of the liquid filling tube box 6, and solenoid valves are installed on the heparin sodium mixture filling tube 601 and the alcohol filling tube 602. A liquid level sensor 603 is installed at the position of the liquid filling tube box 6 close to the reflux tube box 9 to facilitate timely and scientific liquid replenishment and ensure that the liquid level is in a normal state.

[0055] Among them, the inner cavity of the inclined end of the sedimentation box 7 is a concave structure, and the bottom of the inner cavity of the sedimentation box 7 is a diversion oblique block 704 inclined toward the inclined end of the sedimentation box 7. The bottom plate of the inner cavity of the sedimentation box 7 on one side of the diversion oblique block 704 is vertically connected to a sediment extraction pipe 702, and an extraction pump 703 is installed on the sediment extraction pipe 702. A viscosity detection sensor 705 is provided near the bottom of the inner cavity of the sedimentation box 7. A first window 701 is vertically embedded in the side wall of the sedimentation box 7. The viscosity detection sensor 705 is used to detect whether there is enough sodium heparin to be discharged from the area. If so, it is extracted through the sediment extraction pipe 702 using the extraction pump 703. When the viscosity detected by the viscosity detection sensor 705 is lower than the set standard, the extraction pump 703 stops extracting the sediment, and starts again when there is enough sediment in the sedimentation box 7. This reciprocating process can achieve non-stop production, and will not discharge too much lightweight solution, thereby ensuring the output quality of sodium heparin.

[0056] Among them, the lower end of the upflow tube box 8 is a 90-degree bend structure connected to the sedimentation box 7. The middle part of the upflow tube box 8 is vertically rotated with an upflow shaft 801. The lower end of the upflow shaft 801 is fixedly connected to the first bevel gear 1101 on the right-angle conversion frame 11. The upflow wheel 802 and the booster turbine 803 are fixedly installed on the upflow shaft 801. The upflow wheel 802 is located below the booster turbine 803. The upflow wheel 802 is a fan-shaped structure, which can lift and transport the mixed liquid transported from the mixing tube box 5 upward. The upflow wheel 802 initially lifts the fluid, and the booster turbine 803 boosts the lifted fluid, so that the fluid can pass through the upflow tube box 8 smoothly. During the rising process of the fluid, the heavy fluid will not be able to pass through and will gather and flow back to the sedimentation box 7, while the light fluid can pass through, thereby improving the separation effect.

[0057] Among them, the end of the return pipe box 9 connected to the riser pipe box 8 is higher than the end of the return pipe box 9 connected to the liquid replenishment pipe box 6, and the upper end of the liquid replenishment pipe box 6 is higher than the upper end of the riser pipe box 8. The light and heavy components in the fluid can be separated by their own gravity, so that the light fluid is always discharged from the discharge pipe 902;

[0058] A second viewing window 901 is inlaid on the front side wall of the return pipe box 9, through which the internal conditions can be observed;

[0059] The upper end of the front side wall of the reflux pipe box 9 close to the riser pipe box 8 is vertically connected to the drain pipe 902. The drain pipe 902 is a T-shaped three-way structure. One pipe opening of the drain pipe 902 is a discharge pipe opening, on which a solenoid valve is provided, and the other pipe opening is a detection pipe opening, on which a viscosity detector is provided. The pipe opening is refluxed and connected to the infusion pipe box 6 (not shown in the figure), which can cooperate with the sediment extraction pipe 702 and the extraction pump 703 to realize continuous operation of heparin sodium precipitation separation and improve output efficiency.

[0060] Embodiment 2, on the basis of embodiment 1, a through rectangular mounting hole 1001 is provided in the middle of the resonance frame 10, and the upper and lower ends of the mounting hole 1001 are respectively fixedly connected with guide rods 1003 along the resonance frame 10, and the ends of the guide rods 1003 are fixedly connected with the resonance frame 10 through fixed blocks, and the two ends of the guide rods 1003 are respectively fitted with springs 1004, and the opposite ends of the two springs 1004 are respectively fixedly connected with cylindrical resonance blocks 1005 slidably sleeved on the guide rods 1003; a resonance motor 1002 is fixedly installed at the upper middle part of the resonance frame 10, and the resonance motor 1002 can make the spring 1004 and the resonance block 1005 collide with each other to produce a greater vibration effect, which is helpful to eliminate the problem of sediment wall hanging, produce a resonance effect, and accelerate the formation and sedimentation of sediment.

[0061] The working principle of this embodiment:

[0062] The servo motor 501 drives the conveying and mixing shaft 502 to rotate, so that the injected heparin sodium mixed liquid and alcohol can be spirally conveyed and fully mixed during the conveying process by means of the spiral rotation, thereby improving the mixing efficiency. The small pitch of the first-stage mixing spiral auger 503 can increase the mixing path and make the mixing more complete. The small pitch of the second-stage mixing spiral auger 504 can reduce the conveying speed, so that the mixed liquid can be retained at a position above the inner cavity of the sedimentation box 7, so that the heparin sodium precipitate produced therein can be settled, and the light mixed liquid Then it can continue to be transported to the riser box 8 by the second-stage mixing spiral auger 504 and the conveying impeller 505. The second-stage mixing spiral auger 504 and the conveying impeller 505 can also drive the liquid in the inner cavity of the sedimentation box 7 to flow to the side close to the riser box 8 during the rotation process, which can help to increase the sedimentation to be quickly collected at the lower end of the sedimentation box 7. A viscosity detection sensor 705 is provided near the bottom of the inner cavity of the sedimentation box 7. A first window 701 is vertically embedded in the side wall of the sedimentation box 7. The viscosity detection sensor 705 can detect and confirm The pump 703 is used to extract the sediment from the sediment extraction pipe 702. When the viscosity detected by the viscosity detection sensor 705 is lower than the set standard, the pump 703 stops extracting the sediment and starts again when there is enough sediment in the sedimentation box 7. The upflow wheel 802 and the booster turbine 803 are fixedly installed on the upflow shaft 801. The upflow wheel 802 is located below the booster turbine 803. The upflow wheel 802 is a fan-shaped structure, which can lift the mixed liquid transported from the mixing pipe box 5 upward. The upflow wheel 802 initially lifts the fluid, and the booster turbine 803 boosts the lifted fluid, so that the fluid can pass through the upflow pipe box 8 smoothly. In the process of the fluid rising, the heavy fluid will not be able to pass through and will gather and flow back to the sedimentation box 7, while the light fluid can pass through. The supernatant in the reflux pipe box 9 enters the fluid replenishment pipe box 6 again through the reflux effect, and is mixed with the new sodium heparin mixture to achieve a circulation treatment. At the same time, a certain amount of supernatant is discharged through the discharge pipe 902, and its viscosity is tested by a viscosity tester to control the effect of the circulation treatment.

[0063] In this article, there are a few points to note:

[0064] 1. The drawings of the embodiments of the present disclosure only involve structures related to the embodiments of the present disclosure, and other structures may refer to general designs.

[0065] 2. In the absence of conflict, the embodiments of the present disclosure and the features therein may be combined with each other to obtain new embodiments.

[0066] The above are only specific implementation methods of the present disclosure, but the protection scope of the present disclosure is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present disclosure, which should be covered by the protection scope of the present disclosure.

Claims

1. A heparin sodium precipitation and separation device, comprising: A bottom plate (1), a support frame (2), a distribution box (3), a control panel (4), a mixing tube box (5), a liquid replenishing tube box (6), a settling box (7), a rising tube box (8), a return tube box (9), a resonance frame (10) and a right-angle conversion frame (11); characterized in that the left and right ends of the top of the bottom plate (1) are respectively connected upwardly to a cylindrical mixing tube box (5) through a support frame (2) welded from a square tube; one end of the mixing tube box (5) is fixedly provided with a servo motor (501) A liquid replenishment pipe box (6) is vertically connected to the mixing pipe box (5) at the end where the servo motor (501) is located, and a riser pipe box (8) is vertically connected to the other end of the mixing pipe box (5); a return pipe box (9) is provided between the riser pipe box (8) and the liquid replenishment pipe box (6); the left and right ends of the inner cavity of the return pipe box (9) are respectively connected to the inner cavities of the riser pipe box (8) and the liquid replenishment pipe box (6); a sedimentation box (7) is vertically provided at one end of the bottom of the mixing pipe box (5) close to the riser pipe box (8), and the sedimentation box (7) is vertically connected to the riser pipe box (8). The upper end of the inner cavity of the downcomer box (7) is connected to the inner cavity of the mixing tube box (5); a right-angle conversion frame (11) is fixedly provided at the point where the inner cavity of the mixing tube box (5) is connected to the bottom of the inner cavity of the riser tube box (8); the two ends of the right-angle conversion frame (11) are rotatably connected to a first bevel gear (1101) and a second bevel gear (1102) via a rotating shaft; a distribution box (3) is fixedly installed on the top plane of the bottom plate (1); a control panel (4) is fixedly mounted on the support frame (2) below the liquid infusion tube box (6) ; One end of the sedimentation box (7) close to the infusion pipe box (6) is an inclined structure inclined downward, and the inclined end of the sedimentation box (7) is fixedly installed with a resonance frame (10) along the inclined direction; a conveying mixing shaft (502) is rotatably installed in the middle of the inner cavity of the mixing pipe box (5), one end of the conveying mixing shaft (502) is fixedly connected to the rotating shaft of the servo motor (501) through a coupling, and the other end of the conveying mixing shaft (502) is fixedly connected to the second bevel gear (1102) on the right-angle conversion frame (11); The conveying mixing shaft (502) is fixedly mounted with a first-section mixing spiral auger (503) and a second-section mixing spiral auger (504); the first-section mixing spiral auger (503) and the second-section mixing spiral auger (504) are fixedly connected to each other; the first-section mixing spiral auger (503) is close to the liquid infusion pipe box (6); the second-section mixing spiral auger (504) corresponds to the upper part of the inner cavity of the sedimentation box (7); and the pitch of the first-section mixing spiral auger (503) is smaller than the pitch of the second-section mixing spiral auger (504); A fan-shaped conveying impeller (505) is fixedly connected to the end of the second-stage mixing spiral auger (504) near the riser box (8); a heparin sodium mixed liquid replenishing pipe (601) and an alcohol replenishing pipe (602) are respectively vertically connected to the outer side wall of the upper end of the replenishing pipe box (6), and solenoid valves are installed on the heparin sodium mixed liquid replenishing pipe (601) and the alcohol replenishing pipe (602); A liquid level sensor (603) is installed at a position of the liquid replenishment pipe box (6) close to the return pipe box (9); the inner cavity of the inclined end of the sedimentation box (7) is a concave structure, the bottom of the inner cavity of the sedimentation box (7) is a diversion inclined block (704) inclined toward the inclined end of the sedimentation box (7), the bottom plate of the inner cavity of the sedimentation box (7) on one side of the diversion inclined block (704) is vertically connected to a sediment extraction pipe (702), and an extraction pump (703) is installed on the sediment extraction pipe (702); A first viewing window (701) is vertically embedded in the side wall of the sedimentation box (7); A viscosity detection sensor (705) is provided at a position near the bottom of the inner cavity of the sedimentation box (7); the lower end of the riser pipe box (8) is a 90-degree curved pipe structure connected to the sedimentation box (7); a riser shaft (801) is provided in the middle of the riser pipe box (8) for vertical rotation; the lower end of the riser shaft (801) is fixedly connected to a first bevel gear (1101) on a right-angle conversion frame (11); a riser wheel (802) and a booster turbine (803) are fixedly mounted on the riser shaft (801); the riser wheel (802) is located below the booster turbine (803); the riser wheel (802) is a fan-shaped structure; the end of the return pipe box (9) connected to the riser pipe box (8) is higher than the end of the return pipe box (9) connected to the liquid replenishment pipe box (6); the upper end of the liquid replenishment pipe box (6) is higher than the upper end of the riser pipe box (8); A second viewing window (901) is inlaid on the front end side wall of the return pipe box (9); The upper end of the front side wall of the return pipe box (9) close to the riser pipe box (8) is vertically connected to a drain pipe (902), the drain pipe (902) being a T-shaped three-way structure, one pipe opening of the drain pipe (902) being a discharge pipe opening, on which a solenoid valve is provided, and the other pipe opening being a detection pipe opening, on which a viscosity detector is provided, and the pipe opening is refluxed and connected to the liquid replenishment pipe box (6) (not shown in the figure).

2. A heparin sodium precipitation and separation device according to claim 1, characterized in that: A through rectangular mounting hole (1001) is provided in the middle of the resonance frame (10); the upper and lower ends of the mounting hole (1001) are respectively fixedly connected to guide rods (1003) along the resonance frame (10); the ends of the guide rods (1003) are fixedly connected to the resonance frame (10) via a fixing block; the two ends of the guide rods (1003) are respectively sleeved with springs (1004); the opposite ends of the two springs (1004) are respectively fixedly connected to cylindrical resonance blocks (1005) which are slidably sleeved on the guide rods (1003); and the resonance motor (1002) is fixedly mounted at the upper middle portion of the resonance frame (10).

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