A traditional Chinese medicine composition for treating ectopic pregnancy and its enema preparation and application

Abstract

This invention provides a traditional Chinese medicine composition for treating ectopic pregnancy, its enema preparation, and its application. A traditional Chinese medicine enema composition for ectopic pregnancy comprises the following raw materials in parts by weight: 28-35 parts of *Ilex pubescens*, 18-23 parts of rhubarb, 18-23 parts of *Hedyotis diffusa*, 18-23 parts of *Liquidambar formosana*, and 18-23 parts of safflower. This invention also provides a traditional Chinese medicine enema preparation for ectopic pregnancy, comprising the traditional Chinese medicine composition described in any one of the present invention, preferably an enema preparation. This invention targets ectopic pregnancy, using *Ilex pubescens* as the principal herb, and safflower and *Liquidambar formosana* as assistant herbs to enhance the blood-activating and stasis-removing effects of *Ilex pubescens*; rhubarb as the adjuvant herb; and *Hedyotis diffusa* as the guiding herb. The precise combination of these herbs effectively activates blood circulation, clears the meridians, removes stasis, and eliminates masses, resulting in a good therapeutic effect for ectopic pregnancy. This invention uses *Ilex pubescens*, rhubarb, *Hedyotis diffusa*, *Liquidambar formosana*, and safflower in a certain proportion, which has a synergistic effect, resulting in a high cure rate for ectopic pregnancy and good safety.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a traditional Chinese medicine composition for treating ectopic pregnancy, its enema preparation, and its application. Background Technology

[0002] Ectopic pregnancy (also known as extrauterine pregnancy) occurs when a fertilized egg implants and develops outside the uterine cavity, most commonly in the fallopian tubes. Ectopic pregnancy poses a serious threat to a woman's health, potentially leading to fallopian tube rupture, internal bleeding, and even death. Traditional treatments mainly include surgery and medication. While these methods can effectively control the condition, they still have certain side effects, long recovery times, and a higher risk of complications.

[0003] In recent years, with the continuous development of traditional Chinese medicine (TCM), more and more studies have shown that TCM has unique advantages in treating gynecological diseases, especially ectopic pregnancy. TCM, through comprehensive treatment methods such as regulating qi and blood, promoting blood circulation and removing blood stasis, and improving microcirculation, can effectively alleviate patient symptoms and reduce the risk of disease recurrence. However, the TCM compositions currently used to treat ectopic pregnancy are still relatively limited, and effective formulas for targeted treatment are lacking.

[0004] Existing enemas often lack drug formulations specifically targeting the pathological characteristics of ectopic pregnancy, resulting in insufficient drug efficacy and affecting treatment effectiveness and patient compliance. Therefore, developing a traditional Chinese medicine enema composition with good efficacy and safety for ectopic pregnancy has significant clinical application value.

[0005] The present invention aims to provide a new traditional Chinese medicine composition and preparation for treating ectopic pregnancy. By rationally selecting medicinal materials and optimizing the formula, it is expected to improve the therapeutic effect, reduce side effects, and thus improve the clinical prognosis of patients. Summary of the Invention

[0006] In view of this, the present invention proposes a traditional Chinese medicine composition for treating ectopic pregnancy, its enema preparation and application. The traditional Chinese medicine composition of the present invention has good efficacy in treating ectopic pregnancy and is highly safe.

[0007] The technical solution of this invention is implemented as follows:

[0008] A traditional Chinese medicine composition for ectopic pregnancy enema includes the following raw materials in parts by weight: 28-35 parts of Ilex pubescens, 18-23 parts of rhubarb, 18-23 parts of Hedyotis diffusa, 18-23 parts of Liquidambar formosana, and 18-23 parts of safflower.

[0009] Preferably, the herbal composition for ectopic pregnancy enema comprises the following raw materials in parts by weight: 28-32 parts of Ilex pubescens, 19-21 parts of rhubarb, 19-21 parts of Hedyotis diffusa, 19-21 parts of Liquidambar formosana, and 19-21 parts of safflower.

[0010] More preferably, the herbal composition for ectopic pregnancy enema comprises the following raw materials in parts by weight: 30 parts of Ilex pubescens, 20 parts of rhubarb, 20 parts of Hedyotis diffusa, 20 parts of Liquidambar formosana, and 20 parts of safflower.

[0011] The present invention also provides a traditional Chinese medicine enema for ectopic pregnancy, comprising the traditional Chinese medicine composition described in any one of the present invention.

[0012] Furthermore, the preparation method of the enema includes the following: take Ilex pubescens, rhubarb, Hedyotis diffusa, Liquidambar formosana, and safflower, add water and decoct twice. For the first decoction, add 8-10 times the amount of water and decoct for 1-2 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions to obtain the medicinal liquid.

[0013] The application of any one of the traditional Chinese medicine compositions described in this invention in the preparation of a medicament for treating ectopic pregnancy.

[0014] Ilex pubescens Hook. et Arn. (Haloxylon ammodendron): Source: The root of Ilex pubescens Hook. et Arn. (Aquifoliaceae family); Chemical composition: The root contains flavonoids as the active ingredient, as well as phenols, sterols, tannins, triterpenes, amino acids, sugars, etc.; Functions and indications: Promotes blood circulation, reduces swelling and relieves pain, clears heat and detoxifies. Used for angina pectoris, myocardial infarction, thromboangiitis obliterans, central retinitis, tonsillitis, pharyngitis, pediatric pneumonia, and frostbite.

[0015] Rhubarb: This product is the dried root and rhizome of medicinal rhubarb (Rheum officinale Baill.);

[0016] Chemical composition: Contains anthracene derivatives, glycosides, tannins, organic acids, volatile oils, etc.; Functions and indications: Clears heat, breaks up stagnation, and promotes blood circulation. Indications: Constipation due to heat, food stagnation, abdominal pain, acute appendicitis, acute infectious hepatitis, amenorrhea due to blood stasis, toothache, epistaxis, acute conjunctivitis; Externally used to treat burns, scalds, suppurative skin diseases, carbuncles, and sores.

[0017] Hedyotis diffusa: Source: The whole herb of Hedyotis diffusa, a plant belonging to the Rubiaceae family and the Hedyotis genus. Chemical constituents: The whole herb contains scandoside, scandoside acid, deacetylated scandoside acid, scandoside acid, scandoside, methyl scandoside, methyl 6-O-p-hydroxycinnamoyl scandoside, methyl 6-O-p-methoxycinnamoyl scandoside, methyl 6-O-feruloyl scandoside, 2-methyl-3-hydroxyanthraquinone, 2-methyl-3-methoxyanthraquinone, 2-methyl-3-hydroxy-4-methoxyanthraquinone, etc., as well as ursolic acid, β-sitosterol, heptane, stigmasterol, oleanolic acid, β-sitosterol-β-glucoside, p-coumaric acid, etc. Functions and indications: Clears heat and detoxifies; promotes diuresis. Mainly used for lung heat with cough and asthma; sore throat; intestinal abscess; boils and carbuncles; snake bites; painful urination due to heat; edema; dysentery; enteritis; damp-heat jaundice; and cancer.

[0018] Lulutong: This product is the dried, mature inflorescence of the Liquidambar formosana Hance, a plant in the Hamamelidaceae family. The fruit is harvested in winter after ripening, impurities are removed, and then it is dried. Chemical composition: Liquidambar formosana fruit contains 28-norolenic acid, styracin, L-cinnamic acid bornyl ester, epoxidized styracin, isoepoxidized styracin, oxycaryophyllene, betulinic acid, and 24-ethylcholest-5-enol. Functions and indications: Dispels wind and invigorates blood circulation, promotes diuresis and regulates menstruation. Used for joint pain, numbness and contracture, edema, insufficient lactation, and amenorrhea.

[0019] Safflower: This product is the dried flower of *Carthamus tinctorius* L., a plant in the Asteraceae family. Functions and indications: Promotes blood circulation and regulates menstruation, disperses blood stasis and relieves pain. Used for amenorrhea, dysmenorrhea, lochia retention, abdominal masses, traumatic injuries, and sores and swellings.

[0020] Compared with the prior art, the beneficial effects of the present invention are:

[0021] (1) This invention targets ectopic pregnancy and uses Ilex pubescens, rhubarb, Hedyotis diffusa, Liquidambar formosana, and safflower in a certain proportion to prepare an enema, which has a synergistic effect and has a significant therapeutic effect on ectopic pregnancy with a high cure rate and good safety.

[0022] (2) In the formula of this invention, *Ilex pubescens* is bitter, pungent, and cold in nature. Its pungent nature disperses, its bitter nature descends and drains, and its cold nature clears heat. It also enters the blood, thus having the effects of promoting blood circulation, removing blood stasis, clearing heat, and detoxifying. It is the principal herb. *Luffa cylindrica* is bitter and neutral in nature, having the effects of relaxing muscles and tendons, promoting blood circulation, and removing blood stasis. *Carthamus tinctorius* is pungent, dispersing, and warming, a key herb for promoting blood circulation, removing blood stasis, and relieving menstrual pain. Together with *Luffa cylindrica*, it serves as the assistant herb, enhancing the blood-activating and blood-stasis-removing effects of *Ilex pubescens*. *Rheum palmatum* is bitter and cold, having the effects of clearing heat, purging fire, removing blood stasis, and regulating menstruation. It can remove blood stasis and clear heat from stagnant blood, making it a commonly used herb for treating blood stasis syndrome. It is the adjuvant herb. *Hedyotis diffusa* is slightly bitter, sweet, and cold, with a strong effect of clearing heat and detoxifying, and can clear heat from stagnant blood. It is the guiding herb. The combination of these herbs is rigorous, achieving the effects of promoting blood circulation, clearing blood stasis, and eliminating masses. It has a good therapeutic effect on ectopic pregnancy.

[0023] (3) The enema of the present invention can increase the local concentration of the drug and enhance the therapeutic effect by acting directly on the lesion site, while reducing systemic side effects and the risk of systemic drug side effects.

[0024] (4) The enema of the present invention can target the pathological characteristics of ectopic pregnancy, quickly eliminate blood stasis in the body, relieve pain, and improve the condition.

[0025] (5) The enema of the present invention has many advantages such as easy preparation, convenient use, good efficacy, high safety and patient compliance. Detailed Implementation

[0026] To better understand the technical content of this invention, specific embodiments are provided below to further illustrate the invention.

[0027] Unless otherwise specified, the experimental methods used in the embodiments of this invention are all conventional methods.

[0028] Unless otherwise specified, all materials and reagents used in the embodiments of this invention are commercially available.

[0029] Example 1

[0030] A traditional Chinese medicine composition for treating ectopic pregnancy, comprising the following ingredients: 30g of Ilex pubescens, 20g of rhubarb, 20g of Hedyotis diffusa, 20g of Liquidambar formosana, and 20g of safflower.

[0031] Preparation of the enema: Take 30g of Ilex pubescens, 20g of rhubarb, 20g of Hedyotis diffusa, 20g of Liquidambar formosana, and 20g of safflower, decoct them in water, and obtain the medicinal liquid. The specific steps are as follows: Take Ilex pubescens, rhubarb, Hedyotis diffusa, Liquidambar formosana, and safflower, add water and decoct twice. The first time, add 9 times the amount of water and decoct for 1.5 hours; the second time, add 7 times the amount of water and decoct for 1 hour. Combine the two decoctions to obtain the medicinal liquid.

[0032] Example 2

[0033] A traditional Chinese medicine composition for treating ectopic pregnancy, comprising the following ingredients: 28g of Ilex pubescens, 23g of rhubarb, 18g of Hedyotis diffusa, 18g of Liquidambar formosana, and 23g of safflower.

[0034] Preparation of the enema: Take 28g of Ilex pubescens, 23g of rhubarb, 18g of Hedyotis diffusa, 18g of Liquidambar formosana, and 23g of safflower, decoct in water, and obtain the medicinal liquid. Specifically, the following steps are included: Take Ilex pubescens, rhubarb, Hedyotis diffusa, Liquidambar formosana, and safflower, add water and decoct twice. The first time, add 9 times the amount of water and decoct for 1.5 hours; the second time, add 7 times the amount of water and decoct for 1 hour. Combine the two decoctions to obtain the medicinal liquid.

[0035] Example 3

[0036] A traditional Chinese medicine composition for treating ectopic pregnancy, consisting of the following ingredients: 35g of Ilex pubescens, 18g of rhubarb, 23g of Hedyotis diffusa, 23g of Liquidambar formosana, and 18g of safflower.

[0037] Preparation of the enema: Take 35g of Ilex pubescens, 18g of rhubarb, 23g of Hedyotis diffusa, 23g of Liquidambar formosana, and 18g of safflower, decoct in water, and obtain the medicinal liquid. Specifically, the following steps are included: Take Ilex pubescens, rhubarb, Hedyotis diffusa, Liquidambar formosana, and safflower, add water and decoct twice. The first time, add 9 times the amount of water and decoct for 1.5 hours; the second time, add 7 times the amount of water and decoct for 1 hour. Combine the two decoctions to obtain the medicinal liquid.

[0038] Comparative Example 1

[0039] A traditional Chinese medicine composition for treating ectopic pregnancy, which does not contain Ilex pubescens, is composed of the following ingredients: 30g rhubarb, 30g Hedyotis diffusa, 25g Liquidambar formosana, and 25g safflower.

[0040] Preparation of the enema: Take 30g of rhubarb, 30g of oldenlandia diffusa, 25g of luffa cylindrica, and 25g of safflower, decoct them in water, and obtain the medicinal liquid. The specific steps are as follows: Take rhubarb, oldenlandia diffusa, luffa cylindrica, and safflower, add water and decoct twice. The first time, add 9 times the amount of water and decoct for 1.5 hours; the second time, add 7 times the amount of water and decoct for 1 hour. Combine the two decoctions to obtain the medicinal liquid.

[0041] Comparative Example 2

[0042] A traditional Chinese medicine composition for treating ectopic pregnancy, which does not contain rhubarb, is composed of the following ingredients: 30g of Ilex pubescens, 30g of Hedyotis diffusa, 25g of Liquidambar formosana, and 25g of Carthamus tinctorius.

[0043] Preparation of the enema: Take 30g of Ilex pubescens, 30g of Hedyotis diffusa, 25g of Liquidambar formosana, and 25g of Carthamus tinctorius, decoct in water, and obtain the medicinal liquid. The specific steps are as follows: Take Ilex pubescens, Hedyotis diffusa, Liquidambar formosana, and Carthamus tinctorius, add water and decoct twice. The first time, add 9 times the amount of water and decoct for 1.5 hours; the second time, add 7 times the amount of water and decoct for 1 hour. Combine the two decoctions to obtain the medicinal liquid.

[0044] Comparative Example 3

[0045] A traditional Chinese medicine composition for treating ectopic pregnancy, which does not contain Hedyotis diffusa, is composed of the following ingredients: 30g of Ilex pubescens, 30g of rhubarb, 25g of Liquidambar formosana, and 25g of safflower.

[0046] Preparation of the enema: Take 30g of Ilex pubescens, 30g of rhubarb, 25g of Liquidambar formosana, and 25g of safflower, decoct in water, and obtain the medicinal liquid. The specific steps are as follows: Take Ilex pubescens, rhubarb, Liquidambar formosana, and safflower, add water and decoct twice. The first time, add 9 times the amount of water and decoct for 1.5 hours; the second time, add 7 times the amount of water and decoct for 1 hour. Combine the two decoctions to obtain the medicinal liquid.

[0047] Comparative Example 4

[0048] A traditional Chinese medicine composition for treating ectopic pregnancy, which does not contain *Luffa cylindrica*, is composed of the following ingredients: 30g of *Ilex pubescens*, 30g of rhubarb, 25g of *Hedyotis diffusa*, and 25g of safflower.

[0049] Preparation of the enema: Take 30g of Ilex pubescens, 30g of rhubarb, 25g of Hedyotis diffusa, and 25g of safflower, decoct in water, and obtain the medicinal liquid. The specific steps are as follows: Take Ilex pubescens, rhubarb, Hedyotis diffusa, and safflower, add water and decoct twice. The first time, add 9 times the amount of water and decoct for 1.5 hours; the second time, add 7 times the amount of water and decoct for 1 hour. Combine the two decoctions to obtain the medicinal liquid.

[0050] Comparative Example 5

[0051] A traditional Chinese medicine composition for treating ectopic pregnancy, which does not contain safflower, is composed of the following ingredients: 30g of Ilex pubescens, 30g of rhubarb, 25g of Hedyotis diffusa, and 25g of Liquidambar formosana.

[0052] Preparation of the enema: 30g of *Ilex pubescens*, 30g of rhubarb, 25g of *Hedyotis diffusa*, and 25g of *Liquidambar formosana* are decocted in water to obtain the medicinal liquid. The specific steps include: taking *Ilex pubescens*, rhubarb, *Hedyotis diffusa*, and *Liquidambar formosana*, adding water and decocting twice. The first time, add 9 times the amount of water and decoct for 1.5 hours; the second time, add 7 times the amount of water and decoct for 1 hour. Combine the two decoctions to obtain the medicinal liquid.

[0053] I. Clinical Research

[0054] 1.1 General Information: 120 patients with ectopic pregnancy who visited Qionghai City Traditional Chinese Medicine Hospital, aged 20-45 years, were selected and randomly divided into 3 groups: study group 1-2 and control group, with 40 cases in each group. All cases met the diagnostic criteria of both traditional Chinese medicine and Western medicine. There were no statistically significant differences in age and disease condition among the groups (P>0.05), making them comparable.

[0055] 1.2 Diagnostic criteria

[0056] 1.2.1 Traditional Chinese Medicine Diagnostic Criteria

[0057] (1) Many patients have a history of amenorrhea and lower abdominal pain, or irregular vaginal bleeding.

[0058] (2) Gynecological examination: The uterus may be slightly enlarged, and a mass may be palpable in one adnexal region with tenderness.

[0059] (3) β-HCG positive or weakly positive.

[0060] (4) Pelvic ultrasound: No gestational sac is seen in the uterus, an indistinct fluid or mixed echo area is seen beside the uterus, or an embryo or primitive heart tube pulsation is found in the area, or there is an anechoic dark area in the abdominal cavity or fluid accumulation in the rectouterine pouch.

[0061] 1.2.2 Western Medicine Diagnostic Criteria

[0062] When a tubal pregnancy does not result in miscarriage or rupture, the clinical manifestations are not obvious, making diagnosis difficult. Auxiliary examinations are required for a definitive diagnosis.

[0063] (1) Typical symptoms include amenorrhea, abdominal pain, and vaginal bleeding;

[0064] (2) Gynecological examination: There may be a small amount of blood in the vagina, cervical tenderness, slightly enlarged and soft uterus, and a mass may be palpable in one adnexal region with tenderness.

[0065] (3) Laboratory tests: urine or blood HCG positive; in very rare cases, old ectopic pregnancies may have been positive but have now turned negative.

[0066] (4) Ultrasound examination: sonographic features: no gestational sac is detected in the uterus. If an abnormal hypoechoic area is detected in the parametrial region, and the yolk sac, embryo and primitive heart tube pulsation are seen, ectopic pregnancy can be diagnosed. If a mixed echoic area is detected in the parametrial region, and there is a free dark area in the rectouterine pouch, even if the embryo and fetal heart pulsation are not seen, ectopic pregnancy should be highly suspected.

[0067] (5) Transvaginal posterior fornix puncture: When intra-abdominal bleeding is suspected, dark red non-clotting blood can be punctured.

[0068] 1.3 Treatment Methods

[0069] Control group: Methotrexate 50mg, once intramuscularly.

[0070] Study Group 1: Methotrexate 50mg, once intramuscularly; simultaneously administered the enema solution from Example 1.

[0071] Study Group 2: Methotrexate 50mg, once intramuscularly; simultaneously administered the enema solution from Example 2.

[0072] Enema application method: Prepare the solution according to the formulations in Examples 1-2. Before use, heat the solution to about 38°C. Use 150mL for retention enema each time, retaining it for at least 2 hours, once every night. One course of treatment is 7 days, and 1-2 courses of treatment are required.

[0073] 1.4 Evaluation of therapeutic effect

[0074] Recovery: Vaginal bleeding stops, abdominal pain disappears; β-HCG test is negative twice consecutively; gynecological ultrasound examination shows that the gestational mass has shrunk by more than 1 / 2.

[0075] Significant effect: vaginal bleeding stops, abdominal pain disappears; β-HCG level drops to <50 IU / L (follow-up examination continues after discharge until two negative results are obtained); gynecological ultrasound examination shows that the gestational mass has shrunk by more than 1 / 2.

[0076] Effective: vaginal bleeding stops, abdominal pain disappears; β-HCG level drops to <50 IU / L (follow-up examination continues after discharge until two negative results are obtained); gynecological ultrasound examination shows that the gestational mass has shrunk by less than 1 / 2 or has not increased in size.

[0077] Ineffective: worsening abdominal pain or accompanied by hemorrhagic shock; persistently positive β-HCG with an increasing trend; gynecological ultrasound examination shows an enlarged gestational mass.

[0078] Adverse reaction cases are also recorded.

[0079] 1.5 Treatment Results

[0080] Table 1. Efficacy of the Traditional Chinese Medicine Compositions in Examples 1-2 [Examples (%)]

[0081]

[0082] As shown in Table 1, the traditional Chinese medicine composition of the present invention has a significant therapeutic effect on ectopic pregnancy, with a cure rate of 70.0-75.0%, a total effective rate of 100%, and no adverse reactions.

[0083] II. Following the aforementioned clinical research methods, the traditional Chinese medicine compositions used in Comparative Examples 1-5 were employed in the study. One hundred patients with ectopic pregnancy, aged 20-45 years, were selected and randomly divided into 5 groups: experimental groups 1-5, with 20 cases in each group. Experimental groups 1-5 were given methotrexate 50mg (single intramuscular injection) and simultaneously received the corresponding enema from Comparative Examples 1-5.

[0084] Experimental group 1: Administered the enema solution of Comparative Example 1; Experimental group 2: Administered the enema solution of Comparative Example 2;

[0085] Experimental group 3: Administered the same enema as Comparative Example 3; Experimental group 4: Administered the same enema as Comparative Example 4;

[0086] Experimental group 5: Administered the same enema solution as control group 5.

[0087] Enema usage: Prepare the solution according to the formulas in Comparative Ratios 1-5. Before use, heat the solution to approximately 38°C. Use 150mL for retention enema each time, retaining it for at least 2 hours, once every night. One course of treatment is 7 days, and 1-2 courses of treatment are recommended.

[0088] The treatment results are shown in Table 2 below:

[0089] Table 2. Efficacy of the Traditional Chinese Medicine Combinations in Comparative Examples 1-5 [Examples (%)]

[0090]

[0091] As shown in Tables 1-2, compared with study group 1, the cure rate of experimental groups 1-5 was significantly lower. In particular, there were ineffective cases in experimental groups 1 and 4-5. This invention uses a compound of Ilex pubescens, rhubarb, Hedyotis diffusa, Liquidambar formosana, and safflower, which has a synergistic effect.

[0092] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating ectopic pregnancy, characterized in that, It is composed of the following raw materials in parts by weight: 28-35 parts of Ilex pubescens, 18-23 parts of rhubarb, 18-23 parts of Hedyotis diffusa, 18-23 parts of Liquidambar formosana, and 18-23 parts of safflower.

2. The traditional Chinese medicine composition for treating ectopic pregnancy according to claim 1, characterized in that, It is composed of the following raw materials in parts by weight: 28-32 parts of Ilex pubescens, 19-21 parts of rhubarb, 19-21 parts of Hedyotis diffusa, 19-21 parts of Liquidambar formosana, and 19-21 parts of safflower.

3. The traditional Chinese medicine composition for treating ectopic pregnancy according to claim 2, characterized in that, It is composed of the following ingredients in parts by weight: 30 parts of Ilex pubescens, 20 parts of rhubarb, 20 parts of Hedyotis diffusa, 20 parts of Liquidambar formosana, and 20 parts of safflower.

4. An enema for treating ectopic pregnancy, characterized in that, The traditional Chinese medicine composition comprises any one of claims 1 to 3.

5. The enema for treating ectopic pregnancy according to claim 4, characterized in that, The preparation method of the enema includes the following: take Ilex pubescens, rhubarb, Hedyotis diffusa, Liquidambar formosana, and safflower, add water and decoct twice. For the first decoction, add 8-10 times the amount of water and decoct for 1-2 hours. For the second decoction, add 6-8 times the amount of water and decoct for 1-2 hours. Combine the two decoctions to obtain the medicinal liquid.

6. The use of the traditional Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating ectopic pregnancy.

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