Compound insecticide composition as well as preparation method and application thereof

Abstract

The invention provides a compound insecticide composition as well as a preparation method and application thereof, and belongs to the technical field of agricultural insecticides. The compound insecticide composition comprises an effective component and an auxiliary component, the effective component is composed of methoxypiperidine ethyl ester and Benzpyrimoxan, and the weight ratio of methoxypiperidine ethyl ester to Benzpyrimoxan is (5: 1)-(1: 10). The composition has an obvious synergistic effect and has the advantages of low cost, good pesticide effect, long lasting period, small environmental pollution and the like.

Description

Technical Field

[0001] The invention belongs to the technical field of agricultural pesticides, and in particular relates to a compound pesticide composition for cabbage peach aphid and a preparation method thereof. Background Art

[0002] Methoxypiperidin ethyl is the fourth spirocyclic quaternary ketoacid insecticide developed and marketed by Syngenta after Bayer launched spirodiclofen, spiromesifen and spirotetramat. Its molecule contains a keto-enol tautomerization structure and its chemical structure is extremely similar to spirotetramat. This type of compound is a lipid biosynthesis inhibitor with unique chemical structure, novel mode of action, outstanding control effect and low resistance to drug resistance. It is a new hotspot in the research and development of insecticides and acaricides in the world.

[0003] The International Insecticide Resistance Action Committee (IRAC) classifies methylphenidate into Class 23: acetyl-CoA carboxylase (ACCase) inhibitors, tetronic acid and tetronic acid derivatives. Its mechanism of action is a lipid biosynthesis inhibitor. It inhibits the activity of ACCase in the process of fat synthesis in pests, destroys lipid synthesis, and thus blocks the normal energy metabolism of pests, eventually leading to the death of pests. methylphenidate provides a new and effective alternative agent for agricultural production.

[0004] Benzpyrimoxan is a new type of insecticide with an aryl alkoxy pyrimidine structure developed by Nippon Agrochemical Co., Ltd. Its lead compound may come from Nippon Soda Co., Ltd. This product can effectively control rice planthoppers, resistant rice planthoppers, leafhoppers, etc., and has a good market prospect. The development code is: NNI-1501; IUPAC name: 5-(1,3-dioxane-2-yl) pyrimidin-4-yl 4-(trifluoromethyl) benzyl ether; CAS registration number: 1449021-97-9; molecular formula: C 16 H 15 F3N2O3.

[0005] Benzpyrimoxa is highly effective in controlling rice planthoppers and leafhoppers, and has a long-lasting effect. It reduces the insect population in rice fields by inhibiting the molting of planthoppers and leafhoppers. The product has good selectivity and has little effect on non-target organisms such as pollinating insects and natural enemies.

[0006] Over the years, with the extensive use of pesticides in agricultural production, the resistance of Chinese peach aphid has been growing faster and faster, and the resistance has become stronger and stronger. Farmers generally use the method of adding more application dosages, which not only aggravates many disadvantages such as environmental pollution, but also obviously leads to a large reduction in crop yields and a significant increase in production costs. Different components are compounded and combined, and it is judged whether a certain compound is additive, synergistic or antagonistic according to the actual application effect. In most cases, compounding is generally additive, and there are relatively few compound combinations with real synergistic effects, and there are even fewer compound combinations with obvious synergistic effects and very high synergistic ratios. After experimental comparative studies, the inventors found that compounding methylphenidate with Benzpyrimoxan specific components has a very good synergistic effect on Chinese peach aphid within a certain range, and after consulting the literature, no relevant reports and studies on the compounding of the two for Chinese peach aphid were found. Summary of the invention

[0007] The invention provides an agricultural compound insecticide composition and a preparation method and application thereof. The composition has obvious synergistic effect, and has the advantages of low cost, good efficacy, long lasting effect, little environmental pollution, etc.

[0008] In order to achieve the above object, the present invention provides a compound insecticide composition, comprising an active ingredient and an auxiliary ingredient, wherein the active ingredient is composed of ethyl methoxypiperidin and Benzpyrimoxan, and the weight ratio of the two is 5:1 to 1:10.

[0009] Preferably, the weight ratio of the active ingredient ethyl methoxypiperidin to Benzpyrimoxan is 1:1-1:8.

[0010] Preferably, the weight percentage of the active ingredients ethyl methoxypiperidin and Benzpyrimoxan in the agricultural insecticide composition is 1%-90%, preferably 10%-60%.

[0011] It is understood that the content of the active ingredient in the composition of the present invention depends on the application amount when used alone, the mixing ratio of one compound to another compound, the degree of synergistic effect, and is also related to the target disease. Usually, the weight percentage of the active ingredient in the composition is 1% to 90% of the total weight, preferably 5% to 80%. Depending on the type of preparation, the range of active ingredient content varies. Usually, liquid preparations contain 1% to 60% of active substances by weight, preferably 5% to 50%; solid preparations contain 5% to 80% of active substances by weight, preferably 10% to 80%.

[0012] Preferably, the auxiliary components include a carrier and an auxiliary agent, the carrier is one or more of water, a solvent or a filler, and the auxiliary agent includes at least one surfactant, and the added amount of the surfactant is 2%-30% of the total weight of the composition.

[0013] It is understood that the above-mentioned solvents include mineral oil, kerosene, diesel, oils of plant or animal origin such as soybean oil, corn oil, methyl oleate; aliphatic, cyclic and aromatic hydrocarbons such as toluene, xylene, paraffin; alcohols such as ethanol, methanol, propanol, butanol, cyclohexanol; ketones such as cyclohexanone; esters such as lactic acid esters, carbonates; amides, such as N-methylpyrrolidone, fatty acid dimethyl amide; and mixtures thereof.

[0014] Preferably, the water is deionized water; the filler is selected from a mixture of one or more of kaolin, diatomaceous earth, bentonite, attapulgite, white carbon black, starch, and light calcium carbonate; the surfactant is selected from one or more of dispersants, stabilizers, wetting agents, binders, and defoamers.

[0015] Preferably, the auxiliary agent further comprises other functional auxiliary agents, and the other functional auxiliary agents are selected from one or more of antifreeze agents, thickeners, disintegrants, and defoaming agents.

[0016] It is understandable that the emulsifier is selected from Nongru 500# (calcium dodecylbenzene sulfonate), tristyrylphenol polyoxyethylene ether, 600# phosphate (phenylphenol polyoxyethylene ether phosphate), styrene polyoxyethylene ether ammonium sulfate, alkyl diphenyl ether disulfonic acid magnesium salt, triethanolamine salt, Nongru 400# (benzyl dimethylphenol polyoxyethyl ether), Ningru 36# (phenylethylphenol formaldehyde resin polyoxyethyl ether), Nongru 1600# (phenylethylphenol polyoxyethyl polypropylene ether), ethylene oxide-propylene oxide block copolymer, BY series (castor oil polyoxyethylene ether), Nongru 33# (alkylaryl polyoxyethylene polyoxypropylene ether), Span series (sorbitan monostearate), Tween series (dehydrated sorbitan fatty acid ester polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether) One or more of the mixture.

[0017] The dispersant is selected from a mixture of one or more of polycarboxylates, lignin sulfonates, alkylphenol polyoxyethylene ether formaldehyde condensate sulfates, alkylbenzene sulfonate calcium, naphthalenesulfonic acid formaldehyde condensate sodium salts, alkylphenol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene ethers or glycerol fatty acid ester polyoxyethylene ethers.

[0018] The wetting agent is selected from a mixture of one or more of sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, lakai powder BX, wetting and penetrating agent F, saponin powder, silkworm feces or soapberry powder.

[0019] The penetrant is selected from a mixture of one or more of penetrant JFC (fatty alcohol polyoxyethylene ether), penetrant T (diisooctyl maleate sulfonate), azone or organosilicon.

[0020] The antifreeze agent is selected from a mixture of one or more of ethylene glycol, propylene glycol, glycerol or urea.

[0021] The thickener is selected from a mixture of one or more of gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, xanthan gum, bentonite, silicon dioxide or magnesium aluminum silicate.

[0022] The stabilizer is selected from a mixture of one or more of epoxy soybean oil, epichlorohydrin, BHT, ethyl acetate or triphenyl phosphate.

[0023] The disintegrant is selected from a mixture of one or more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate.

[0024] The defoaming agent is selected from a mixture of one or more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds.

[0025] The above-mentioned substances can all be purchased from the market.

[0026] Preferably, the formulation of the agricultural insecticide composition is one of wettable powder, water dispersible granules, water suspension, emulsifiable concentrate, water emulsion, microemulsion, suspoemulsion and dispersible oil suspension.

[0027] For example, when the composition is made into a wettable powder, it contains the following components and contents: 0.01% to 80% of methylphenidate, 0.01% to 80% of Benzpyrimoxan, 1% to 12% of a dispersant, 1% to 8% of a wetting agent, and the remainder of filler.

[0028] The composition comprises the following components and contents when it is made into water-dispersible granules: 0.01% to 80% of methylphenidate, 0.01% to 80% of Benzpyrimoxan, 1% to 12% of dispersant, 1% to 8% of wetting agent, 1% to 10% of disintegrant, 0% to 8% of binder and the rest of filler.

[0029] The composition comprises the following components and contents when it is made into a suspension: 0.01% to 50% of methylpiperidin ethyl ester, 0.01% to 50% of Benzpyrimoxan, 1% to 10% of a dispersant, 1% to 10% of a wetting agent, 0.01% to 2% of a defoaming agent, 0% to 2% of a thickener, 0% to 8% of an antifreeze agent, and deionized water added to 100%.

[0030] When the composition is made into emulsifiable concentrate, it comprises the following components and contents: 0.01% to 30% of methylphenidate, 0.01% to 30% of Benzpyrimoxan, 1% to 20% of emulsifier, and the solvent is added to 100%.

[0031] The composition comprises the following components when it is made into a soluble solution: 0.01% to 30% of methylphenidate, 0.01% to 30% of Benzpyrimoxan, 2% to 50% of a solvent, 1% to 10% of a wetting agent, 1% to 20% of an emulsifier, 0% to 8% of an antifreeze agent, 0.01% to 2% of a defoaming agent, and deionized water added to 100%.

[0032] The composition comprises the following components and contents when it is made into an aqueous emulsion: 0.01% to 30% of methoxypiperidin ethyl ester, 0.01% to 30% of Benzpyrimoxan, 1% to 50% of a solvent, 1% to 15% of an emulsifier, 0% to 8% of an antifreeze agent, 0.01% to 2% of a defoaming agent, 0% to 2% of a thickener, and deionized water added to 100%.

[0033] The composition comprises the following components and contents when it is made into microemulsion: 0.01%-30% of methylphenidate, 0.01%-30% of Benzpyrimoxan, 3%-25% of emulsifier, 1%-50% of solvent, 0-8% of antifreeze agent, 0.01%-2% of defoamer and deionized water added to 100%.

[0034] The composition comprises the following components and contents when it is made into a dispersible oil suspension: 0.01% to 50% of methoxypiperidin ethyl ester, 0.01% to 50% of Benzpyrimoxan, 1% to 20% of an emulsifier, 1% to 10% of a dispersant, 0.01% to 2% of a defoamer, 0% to 5% of a thickener, 0% to 8% of an antifreeze agent, and methyl oleate or other oils such as soybean oil, rapeseed oil, and corn oil are continuously added to 100%.

[0035] The present invention also provides an application of the compound insecticide composition according to any of the above technical solutions, wherein the compound insecticide composition is used for the prevention and control of Hemipteran pests such as Coleoptera, Lepidoptera, Diptera, Thysanoptera pests and mites in crops such as vegetables, cotton, fruit trees, corn, tobacco, flowers, melons, beans, etc.

[0036] Preferably, the Hemiptera pests are selected from one or more of cabbage peach aphid, cotton aphid, pear scale insect, soybean aphid, Spodoptera litura, Plutella xylostella, tobacco thrips and red spider.

[0037] Preferably, the compound insecticide composition is applied to Pseudomonas australis in cabbage crops.

[0038] The main technical indicators of various formulations of the present invention all meet the requirements of relevant standards such as NY / T 2989-2016- "Specifications for the Development of Pesticide Registration Product Specifications".

[0039] Compared with the prior art, the advantages and positive effects of the present invention are:

[0040] The compound insecticide composition provided by the present invention has excellent synergistic effect, which can effectively improve its killing effect on pests; 2. The control efficacy is strong, the lasting effect period is long, the resistance risk is small, and it is safe for the environment; 3. When using the composite preparation, the dosage of the two nematicides is reduced compared with when used alone, which improves the control effect of the active ingredients and reduces pesticide residues and environmental pollution; 4. It is composed of effective ingredients with different action mechanisms, which complement each other, which is conducive to overcoming and delaying the development of pest resistance and is safe for crops. DETAILED DESCRIPTION

[0041] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0042] The control effect of methylphenidate and Benzpyrimoxan on cabbage peach aphid was tested in different ratios. The test method is as follows:

[0043] The embodiment of the present invention adopts a method combining indoor toxicity determination and field test. First, the co-toxicity coefficient (CTC) of two drugs after compounding in a certain ratio is determined by indoor toxicity determination. CTC < 80 is antagonistic effect, 80 ≤ CTC ≤ 120 is additive effect, and CTC > 120 is synergistic effect. On this basis, field test is carried out.

[0044] Test method: During the test, the mother solution of the water suspension of each mixed agent was diluted into five series of concentrations and placed in beakers for standby use. The method of soaking the leaves first and then inoculating the insects was adopted. The leaves of the same size that had not been exposed to any pesticides were soaked in the prepared solution for 5 seconds, then taken out, dried naturally, and placed in an insect box. Then, the test larvae were inoculated and raised at 25°C. Each treatment was repeated 3 times, and the number of test insects used in each repetition was 50. At the same time, a blank control was set up. The number of dead insects was checked at 72 hours, and the mortality rate and corrected mortality rate were calculated. The toxicity regression equation was obtained and the LC50 value was calculated. If the control mortality rate is greater than 10%, the test is considered invalid. The calculation formula is as follows:

[0045]

[0046]

[0047] The corrected mortality of pests was converted into a probability value (y), and the treatment concentration (μg / ml) was converted into a logarithmic value (x). The toxicity regression equation was obtained by the least square method, and the value of each agent was calculated from it. The co-toxicity coefficient CTC was calculated according to the Sun Yunpei formula. The calculation formula is as follows (with methylphenidate as the standard agent, its toxicity index is 100):

[0048]

[0049]

[0050] Theoretical toxicity index (TTI) of M = TI of ethyl methoxypiperidin × P 甲氧哌啶乙酯 + Effective Benzpyrimoxan TI×P Benzpyrimoxan

[0051]

[0052] Where: M is a mixture of different proportions

[0053] P 甲氧哌啶乙酯 is the proportion of ethyl methoxypiperidin in the composition

[0054] P Benzpyrimoxan is the proportion of Benzpyrimoxan in the composition

[0055] The results of toxicity assay are shown in Table 1, and the results of synergistic assay are shown in Table 2. Among them, CK1 is a single dose of methylphenidate, and CK2 is a single dose of Benzpyrimoxan.

[0056] Table 1 The results of toxicity test of different ratios of methylphenidate and Benzpyrimoxan to Psoralea persicae

[0057]

[0058]

[0059] Table 2 The results of the synergistic effect of different ratios of methoxypiperidin ethyl ester and Benzpyrimoxan on Chinese peach aphid

[0060] Pharmacy Actual Observed Value ATI Theoretical value TTI CTC Methoxypiperidin ethyl ester:Benzpyrimoxan=10:1 102.69 95.44 107.6 Methoxypiperidin ethyl ester:Benzpyrimoxan=5:1 117.90 91.38 129.02 Methoxypiperidin ethyl ester:Benzpyrimoxan=2:1 121.88 83.28 146.35 Methoxypiperidin ethyl ester:Benzpyrimoxan=1:1 126.58 74.66 169.55 Methoxypiperidin ethyl ester:Benzpyrimoxan=1:2 127.27 66.04 192.71 Methoxypiperidin ethyl ester:Benzpyrimoxan=1:3 129.51 61.99 208.92 Methoxypiperidin ethyl ester:Benzpyrimoxan=1:4 105.74 59.46 177.85 Methoxypiperidin ethyl ester:Benzpyrimoxan=1:8 96.19 54.89 175.22 Methoxypiperidin ethyl ester:Benzpyrimoxan=1:10 72.29 53.88 134.17 Methoxypiperidin ethyl ester:Benzpyrimoxan=1:12 70.26 53.22 132.02

[0061] It can be seen from Table 1 and Table 2 that the co-toxicity coefficients of methylphenidate and Benzpyrimoxan at weight ratios of 5:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:8, 1:10, and 1:12 were all greater than 120, showing a synergistic effect, and the synergistic effect was most obvious at weight ratios of 1:1, 1:2, 1:3, 1:4, and 1:8. This shows that the use of a compound preparation of methylphenidate and Benzpyrimoxan at a weight ratio of 5:1 to 1:10 to control cabbage peach aphid is reasonable and feasible.

[0062] The above method was used to determine the control effects on cotton aphids, pear scale insects and soybean aphids, and the synergistic coefficients within different ratio ranges were calculated. It was concluded that ethyl methoxypiperidin and Benzpyrimoxan showed a synergistic effect when the weight ratio was 5:1:2:1:1:1:1:2:1:3:1:4:1:8:1:10:1:12, and the synergistic effect was most obvious at 1:1:1:2:1:3:1:4:1:8.

[0063] The present invention is described in detail below with reference to the examples. The percentages in the examples are all weight percentages, but the present invention is not limited thereto, and the treatment dosages for field efficacy are all dosages of active ingredients.

[0064] Wettable powders are as follows:

[0065] Example 1: (50% Benzpyrimoxan ethyl ester · Benzpyrimoxan wettable powder) 1:3

[0066] Components and contents: 12.5% ​​ethyl methoxypiperidin; 37.5% Benzpyrimoxan; 5% sodium dodecyl sulfate as wetting agent; 8% calcium lignin sulfonate as dispersant; 4% naphthalene sulfonate as dispersant; 5% white carbon black as filler and the balance of kaolin.

[0067] Example 2: (70% Benzpyrimoxan ethyl ester · Benzpyrimoxan wettable powder) 1:6

[0068] Components and contents: 10% ethyl methoxypiperidin; 60% Benzpyrimoxan; 3% sodium dodecylbenzenesulfonate as wetting agent; 7% calcium alkylbenzenesulfonate as dispersant; 3% naphthalenesulfonate as dispersant; 5% white carbon black as filler and the balance as light calcium carbonate.

[0069] Example 3: (11% Benzpyrimoxan ethyl ester · Benzpyrimoxan wettable powder) 1:0.1

[0070] Components and contents: ethyl methoxypiperidin: 10%; Benzpyrimoxan: 1%; wetting agent selected from pull open powder BX: sodium dodecylbenzene sulfonate and wetting penetrant F, the dosage is 1%, 1%, and 1% respectively; dispersant selected from polycarboxylate and naphthalene sulfonate, the dosage is 1% and 3% respectively; white carbon black: 3%; filler selected from diatomaceous earth: 20%, kaolin: the balance.

[0071] The preparation method of the above-mentioned embodiments 1 to 3 is as follows: according to the components and their weight percentages provided in the embodiments, the active ingredients Benzpyrimoxan and methylphenidate are added to the filler, and auxiliary agents such as a wetting agent and a dispersant are added thereto, mixed evenly, and then mixed again after air flow pulverization to obtain a wettable powder. The main equipment includes a mixer and an air flow pulverizer.

[0072] In the above examples, all indicators of the formulation samples meet the requirements of NY / T 2989-2016- "Specifications for the Development of Pesticide Registration Product Specifications".

[0073] The water dispersible granules are as follows:

[0074] Example 4: (30% Benzpyrimoxan water dispersible granules) 1:2

[0075] Components and contents: ethyl methoxypiperidin: 10%; Benzpyrimoxan: 20%; Wetting agent sodium dodecylbenzenesulfonate: 3%; Dispersant alkylnaphthalenesulfonate formaldehyde condensate: 8%; Filler attapulgite: balance.

[0076] Example 5: (40% Benzpyrimoxan water dispersible granules) 1:3

[0077] Components and contents: ethyl methoxypiperidin: 10%; Benzpyrimoxan: 30%; wetting agent saponin powder: 3%; dispersant naphthalenesulfonic acid formaldehyde condensate sodium salt: 2%; dispersant polycarboxylate: 2%; filler attapulgite, the balance.

[0078] The preparation method of the above-mentioned embodiments 4-5 is as follows: according to the components and their weight percentages provided in the embodiments, the active ingredients Benzpyrimoxan and methylpiperidin ethyl ester are added to the filler, and auxiliary agents such as a wetting agent and a dispersant are added thereto, mixed, and after air flow pulverization, 5-20% of water is added, and then kneading, granulation, drying, and screening are performed to obtain a water-dispersible granule product; or the pulverized powder is sprayed with water, granulated, dried, and then sieved in a boiling granulator to obtain the product; or the material can be first made into a suspension according to a certain proportion, and then centrifugal spray drying or high tower spray drying is performed to obtain a dry suspension. The main equipment includes a mixer: an air flow pulverizer, a kneader, an extrusion granulator, a drying room or a fluidized bed drying, or a boiling granulator, a screening machine, a shear emulsifying disperser, a sand mill, a centrifugal spray dryer, and a high tower spray dryer.

[0079] All indicators of the above examples and formulation samples meet the requirements of NY / T 2989-2016- "Specifications for the Development of Pesticide Registration Product Specifications".

[0080] The suspension is as follows:

[0081] Example 6: (40% Benzpyrimoxan ethyl ester · Benzpyrimoxan suspension) 1:3

[0082] Components and contents: 10% ethyl methoxypiperidin; 30% Benzpyrimoxan; 2% sodium lauryl sulfate as wetting agent; 2% polycarboxylate as dispersant; 2% phosphate as dispersant; 0.1% and 1% xanthan gum and aluminum magnesium silicate as thickeners; 5% ethylene glycol as antifreeze agent; 0.2% silicone compound as defoaming agent; and the balance of water.

[0083] Example 7: (5.5% benzopyrimoxan ethyl ester·Benzpyrimoxan suspension) 1:10

[0084] Components and contents: ethyl methoxypiperidin: 0.5%; Benzpyrimoxan: 5%; wetting agent sodium lauryl sulfate: 1%; dispersant alkylphenol polyoxyethylene ether: 3%; dispersant polycarboxylate: 2%; thickeners are xanthan gum and aluminum magnesium silicate, with dosages of 0.15% and 2% respectively; antifreeze agent ethylene glycol: 5%; defoaming agent silicone oil: 0.2%; water: balance.

[0085] Comparative Example 1: (30% Benzpyrimoxan suspension)

[0086] Components and contents: Benzpyrimoxan: 30%; wetting agent sodium lauryl sulfate: 2%; dispersant polycarboxylate: 2%; dispersant phosphate: 3%; dispersant alkylphenol polyoxyethylene ether: 2%; thickeners are xanthan gum and magnesium aluminum silicate, with dosages of 0.1% and 0.8% respectively; antifreeze agent ethylene glycol: 5%; defoaming agent silicone oil: 0.2%; water: balance.

[0087] Comparative Example 2: (30% methylphenidate suspension)

[0088] Components and contents: 30% ethyl methoxypiperidin; 2% sodium lauryl sulfate wetting agent; 2% polycarboxylate dispersant; 3% phosphate dispersant; 2% high molecular polymer dispersant; xanthan gum and aluminum magnesium silicate thickeners, in amounts of 0.1% and 1% respectively; 5% ethylene glycol antifreeze agent; 0.2% silicone oil defoaming agent; balance water.

[0089] The preparation methods of the above-mentioned Examples 6 to 7 and Comparative Examples 1 and 2 are as follows: according to the components and their weight percentages provided in the examples, the active ingredient Benzpyrimoxan and methylphenidate, a wetting agent, a dispersant, a thickener, an antifreeze agent, a defoaming agent and other auxiliary agents are sequentially placed in a reaction kettle, water is added to mix evenly, high-speed shearing, wet sand milling, and finally homogenization filtration are performed to obtain the product. The main equipment is a batching kettle, a colloid mill or a homogenizing mixer, and a sand mill.

[0090] In the above embodiments and comparative examples, all indicators of the formulation samples meet the requirements of NY / T 2989-2016- "Specifications for the Development of Pesticide Registration Product Specifications".

[0091] The dispersible oil suspensions are as follows:

[0092] Example 8: (20% ethyl methoxypiperidin·Benzpyrimoxan dispersible oil suspension) 1:1 components and content: ethyl methoxypiperidin: 10%, Benzpyrimoxan: 10%, calcium dodecylbenzenesulfonate: 3%, castor oil polyoxyethylene ether: 10%, fatty alcohol polyoxyethylene ether: 3%, organic clay and fumed silica as thickeners, and methyl oleate as the balance.

[0093] Example 9: (25% ethyl methoxypiperidin·Benzpyrimoxan dispersible oil suspension) 2:3 components and contents: ethyl methoxypiperidin: 10%, Benzpyrimoxan: 15%, calcium dodecylbenzenesulfonate: 4%, castor oil polyoxyethylene ether: 12%, fatty alcohol polyoxyethylene ether: 2%, isomeric alcohol ether: 2%, organic clay and fumed silica are selected as thickeners, and methyl oleate is the balance.

[0094] The preparation method of the above-mentioned embodiments 8 to 9 is as follows: according to the components and their weight percentages provided in the embodiments, methyl oleate, the active ingredient Benzpyrimoxan and ethyl methoxypiperidin, emulsifiers, dispersants, thickeners, antifreeze agents, defoamers and other auxiliary agents are placed in a reaction kettle in sequence, mixed evenly, subjected to high-speed shearing, wet sand milling, and finally homogenized filtration to obtain the product. The main equipment is a batching kettle, a colloid mill or a homogenizing mixer, and a sand mill.

[0095] In the above examples, all indicators of the formulation samples meet the requirements of NY / T 2989-2016- "Specifications for the Development of Pesticide Registration Product Specifications".

[0096] The following field spray test was carried out on cabbage peach aphid using the agents of Examples 1, 4, 6, 8 and the agents of Comparative Examples 1 and 2 at the dilution multiples shown in Table 3. Three concentration gradients were set according to different dilution multiples. Under each concentration gradient, the content of the active ingredient in the dilution solution of the different agents was the same, so as to more comprehensively and accurately illustrate the effect of the present invention. The test results are shown in Table 3 below. Wherein: Example 1: 50% Benzpyrimoxan ethyl methoxypiperidin wettable powder (12.5+37.5); Example 4: 30% Benzpyrimoxan ethyl methoxypiperidin water dispersible granules (10+20); Example 6: 40% Benzpyrimoxan ethyl methoxypiperidin water suspension (10+30); Example 8: 20% Benzpyrimoxan ethyl methoxypiperidin dispersible oil suspension (10+10); Comparative Example 1: 30% Benzpyrimoxan water suspension, Comparative Example 2: 30% Benzpyrimoxan ethyl methoxypiperidin water suspension.

[0097] In this test, there are 11 treatments, including the agents of Examples 1 to 8, the agents of Comparative Examples 1 to 2, and no agent. Each treatment is repeated 4 times, with a total of 44 treatment plots. Spraying is carried out at the early stage of the occurrence of peach aphids in cabbage, and the amount of liquid sprayed in each plot is the same. Three points are randomly selected from each treatment plot, and 8 cabbages are selected from each point. The number of live insects on the cabbage is investigated before the application of the drug, 1 day, 3 days, and 7 days after the application of the drug. The control effect of each treatment is calculated based on the natural insect population increase and decrease rate of the control area. At the same time, the growth of the cabbage in each plot is observed and recorded: the occurrence of drug damage.

[0098] Calculation method of drug efficacy:

[0099] Reduction rate (%) = {(number of insects before medication - number of insects after medication) / number of insects before medication} × 100

[0100] Control effect (%) = {(pest population reduction rate in the control area - pest population reduction rate in the control area) / (100 - pest population reduction rate in the control area)} × 100

[0101] The significance was determined by the “DMRT” method.

[0102] Table 3 Control effect of different treatments on Chinese peach aphid

[0103]

[0104]

[0105] From the test results in Table 3, it can be seen that under the same dosage, after 1 day, 3 days, and 7 days of application, the control effects of the agents in Example 1, Example 4, Example 6, and Example 8 on cabbage peach aphid were significantly higher than those in Comparative Example 1 and Comparative Example 2, all of which were above 85%. Moreover, the effect of the compound agent was still significantly higher than that of the comparative agents 1 to 2 at a higher multiple dilution concentration, and the agent had a long lasting effect, and still achieved a good control effect 7 days after application. During the experiment, it was observed that the agents in each embodiment had no phytotoxicity to cabbage and had good safety. The above results show that the compounding of methylphenidate and Benzpyrimoxan has the advantages of significant synergistic effect and prolonged efficacy.

Claims

1. A compound insecticide composition, characterized in that: The invention comprises active ingredients and auxiliary ingredients. The active ingredients are composed of methylphenidate and Benzpyrimoxan, and the weight ratio of the two is 5:1 to 1:

10.

2. The compound insecticide composition according to claim 1, characterized in that: The weight ratio of the active ingredients ethyl methoxypiperidin and Benzpyrimoxan is 1:1-1:

8.

3. The compound insecticide composition according to claim 1 or 2, characterized in that: The weight percentage of the active ingredients methylphenidate and Benzpyrimoxan in the agricultural insecticide composition is 1%-90%, preferably 10%-60%.

4. The compound insecticide composition according to claim 3, characterized in that: The auxiliary components include carriers and auxiliary agents. The carrier is one or more of water or fillers. The auxiliary agent includes at least one surfactant. The added amount of the surfactant is 2%-30% of the total weight of the composition.

5. The compound insecticide composition according to claim 4, characterized in that: The water is deionized water; the filler is selected from a mixture of one or more of kaolin, diatomaceous earth, bentonite, attapulgite, white carbon black, starch, and light calcium carbonate; The surfactant is selected from one or more of a dispersant, a stabilizer, a wetting agent, a binder, and a defoaming agent.

6. The compound insecticide composition according to claim 4, characterized in that: The auxiliary agent also includes other functional auxiliary agents, and the other functional auxiliary agents are selected from one or more of antifreeze agents, thickeners, disintegrants, and defoaming agents.

7. The compound insecticide composition according to any one of claims 1 to 6, characterized in that: The dosage form of the agricultural insecticide composition is one of wettable powder, water dispersible granules, water suspension, emulsifiable concentrate, water emulsion, microemulsion, suspoemulsion and dispersible oil suspension.

8. The use of the compound insecticide composition according to any one of claims 1 to 7, characterized in that: The compound insecticide composition is used for preventing and controlling Hemiptera pests such as Coleoptera, Lepidoptera, Diptera, Thysanoptera pests and mites in crops such as vegetables, cotton, fruit trees, corn, tobacco, flowers, melons, beans and the like.

9. The use according to claim 8, characterized in that: The hemiptera pests are selected from one or more of cabbage peach aphids, cotton aphids, pear scale insects, soybean aphids, Spodoptera litura, diamondback moth, tobacco thrips, and red spider mites.

10. The use according to claim 9, characterized in that: The compound insecticide composition is applied to the cabbage green peach aphid in cabbage crops.

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