Brain region dividing device
By designing a brain area division device and determining the window size and position by CT and nuclear magnetic scanning, the problem of craniotomy in brain areas was solved, and the precise division and efficient collection of multi-brain area research was achieved, which improved the success of craniotomy surgery. Rate.
Patent Information
- Application Number
- CN202411505401.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-25
- Publication Date
- 2024-12-13
AI Technical Summary
The lack of a device that can divide the craniotomy areas according to different brain regions of non-human primates makes it difficult to accurately conduct craniotomy for specific brain regions when collecting brain nerve signals, affecting research efficiency and surgical success rate.
Design a brain region division device, including the main structure and cover, determine the window size and position through CT and nuclear magnetic scanning, set up multiple windows to meet the research needs of different brain regions, and fix them on the skull through adhesive layers and connecting screws. , reduce the number of craniotomy surgeries and improve the success rate.
It has achieved accurate division of brain regions according to research needs, reduced the number of craniotomy surgeries, improved the success rate, met the research needs of multi-brain regions, enhanced structural strength and lightweight design.
Smart Images
Figure CN119112420A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to a brain region dividing device, in particular to a brain region dividing device used for dividing a craniotomy area according to different brain regions of a non-human primate. Background Art
[0002] According to the national research on brain science and brain-like science, there are currently brain science research oriented to explore the secrets of the brain and overcome brain diseases, and brain-like research oriented to establish and develop artificial intelligence technology. To this end, it is necessary to understand brain nerve signal control through animal brain-like research.
[0003] In order to understand brain nerve signals, it is usually necessary to collect brain nerve signals from non-human primates, such as monkeys. Currently, electrodes are implanted to collect brain nerve signals, and for this purpose, the non-human primates need to be craniotomized. Currently, there is a lack of a brain region division device that can be used to divide brain regions according to the needs of multi-brain region research. Summary of the invention
[0004] Therefore, the object of the present invention is to provide a brain region division device, by which the craniotomy area can be divided according to different brain regions of non-human primates and the craniotomy can be performed on the corresponding brain region through the corresponding window according to different research needs.
[0005] The objective can be achieved by a brain region dividing device, which is configured to divide the craniotomy area according to different brain regions of a non-human primate so as to enable craniotomy to be performed on the corresponding required brain region, wherein the brain region dividing device comprises a main structure, which can be fixed on the skull of a non-human primate, and in which a plurality of windows for specifying the craniotomy area are arranged, wherein the respective sizes and positions of the plurality of windows respectively correspond to the different brain regions of the non-human primate, and cross beams for reinforcement and separation are arranged between the windows.
[0006] In the brain region division device according to the present invention, by setting multiple windows, it is possible to perform craniotomy on the corresponding brain regions, such as motor, visual, and behavioral brain regions, through the corresponding windows according to research needs, so as to implant electrodes and collect corresponding brain nerve signals. The size and position of each window can be determined according to the results of CT skull scan and MRI brain region scan, so as to accurately design each window. Different brain region research task requirements can be met through different windows, and the number of craniotomy operations can be greatly reduced, while the success rate of craniotomy operations can be increased.
[0007] In some embodiments, at least some of the plurality of windows may be symmetrically arranged about a longitudinal center axis of the main structure.
[0008] In some embodiments, the brain region division device may also include a cover, and each window in the main structure is respectively equipped with a cover, and the cover is configured to cover the window corresponding to the brain region after a craniotomy is performed on the corresponding brain region.
[0009] In some embodiments, the size of the outer periphery of the cover may match the size of the inner periphery of the corresponding window.
[0010] In some embodiments, the cover may be configured to be fixed to the window via an adhesive layer, at least a portion of the adhesive layer being disposed between an outer periphery of the cover and an inner periphery of the corresponding window.
[0011] In some embodiments, a raised portion may be provided on a section of the main structure surrounding the window, the raised portion being configured to additionally secure an adhesive layer, wherein the adhesive layer is configured to extend beyond the window area and a portion of the adhesive layer is configured to be disposed around the raised portion so as to be additionally secured to the raised portion.
[0012] In some embodiments, the protrusion may be configured in a T-shape.
[0013] In some embodiments, a plurality of first holes may be provided in the main structure, wherein the first holes are configured to allow connecting screws to pass therethrough, and the connecting screws are configured to fix the main structure to the skull by threaded connection.
[0014] In some embodiments, the first hole can be arranged in the area of the front skirt of the main structure and / or in the intersection area of the crossbeam and / or in the transition area from the crossbeam to the side and / or in the rear area of the main structure.
[0015] In some embodiments, the geometry of the inner surface of the main structure can be compatible with the geometry of the outer surface of the skull of a non-human primate, so that the main structure can fit on the skull of the non-human primate when fixed.
[0016] In some embodiments, side skirts may be provided on both sides of the main structure, and the side skirts are configured to fix the scalp of a non-human primate to the main structure.
[0017] In some embodiments, a second hole may be provided in the side skirt, wherein the second hole is configured to allow surgical sutures to pass through so as to fix the scalp to the side skirt by sewing.
[0018] In some embodiments, the main structure may be provided with external mounting holes on both sides and / or in the rear central region, and the external mounting holes are used for installing other accessories and / or for passing the electrode wire.
[0019] In some embodiments, the main structure may be constructed in one piece. BRIEF DESCRIPTION OF THE DRAWINGS
[0020] The present invention will be further described below with reference to the accompanying schematic drawings by means of exemplary embodiments, wherein:
[0021] Figure 1 is a schematic perspective view of a brain region dividing device with a cover and a main body structure according to an exemplary embodiment of the present invention.
[0022] Figure 2 is a schematic perspective view of a cover of a brain region segmentation device according to an exemplary embodiment of the present invention.
[0023] Figure 3 It is a schematic diagram of an exploded view of a brain region division device according to an exemplary embodiment of the present invention. DETAILED DESCRIPTION
[0024] Figure 1 It is a schematic perspective view of the main structure of a brain region division device according to an exemplary embodiment of the present invention. Figure 2 is a schematic perspective view of a cover of a brain region segmentation device according to an exemplary embodiment of the present invention. Figure 3 FIG. 1 is an exploded schematic diagram of a brain region dividing device with a cover according to an exemplary embodiment of the present invention. Figures 1 to 3 The brain region segmentation device according to the present invention is described in detail.
[0025] like Figure 1As shown, the brain region division device may include a main structure 1. A plurality of windows 11 for specifying craniotomy areas are provided in the main structure 1, and the corresponding sizes and positions of the plurality of windows 11 correspond to different brain regions of non-human primates, respectively. Here, a total of 10 windows 11 are provided, that is, an even number of windows 11 are provided, and these windows 11 are symmetrically arranged about the longitudinal center axis of the main structure 1. In other embodiments, an odd number of windows 11 may also be provided, wherein some windows 11 may be symmetrically arranged about the longitudinal center axis of the main structure 1, and other windows 11 may span the longitudinal center axis. In addition, a crossbeam 12 for reinforcement and separation is provided between the windows 11. The structural strength can be enhanced by the crossbeam 12. In order to achieve a good fit between the main structure 1 and the skull of a non-human primate, the geometric structure of the inner surface of the main structure 1 is adapted to the geometric structure of the outer surface of the skull of a non-human primate. This can be achieved through CT skull scanning, through which the precise outer surface geometry of the skull can be obtained, so that the inner surface geometry of the main structure 1 can be designed based on the outer surface geometry of the skull.
[0026] The main structure 1 in the brain region division device can meet the design requirements of both structural strength and lightweight design. The main structure 1 can be constructed in one piece by 3D printing technology, so that the structure is simpler and the manufacturing process is easier. In addition, by adopting 3D printing technology, the cost can be greatly reduced compared to CNC processing design. The main structure 1 can be made of titanium alloy TC4 material.
[0027] In addition to the main structure 1, such as Figures 1 to 3 As can be clearly seen in the figure, the brain region division device also includes a cover 2. Each window 11 in the main structure 1 is respectively equipped with a cover 2, so a total of 10 covers 2 are also provided here. The cover 2 can also be called a bone piece. The cover 2 is configured to cover the window 11 corresponding to the brain region after a craniotomy is performed on the corresponding brain region. The size of the outer periphery of the cover 2 matches the size of the inner periphery of the corresponding window 11, so that the cover 2 can basically fit the window 11. The cover 2 is configured to be fixed at the window 11 by an adhesive layer, and a part of the adhesive layer is arranged between the outer periphery of the cover 2 and the inner periphery of the corresponding window 11. As a result, on the one hand, the window 11 can be sealed with the help of the adhesive layer through the cover 2, and on the other hand, the cover 2 itself can protect the brain region corresponding to the window 11 to prevent the brain region from being infected. The adhesive layer can be composed of bone cement, for example.
[0028] like Figure 1As can be clearly seen in the figure, a protrusion 13 is provided on the section of the main structure 1 surrounding the window 11. The protrusion 13 is configured to additionally fix the adhesive layer, wherein the adhesive layer is configured to extend beyond the window 11 area and a part of the adhesive layer is configured to be arranged around the protrusion 13 so as to be additionally fixed on the protrusion 13. These protrusions 13 can be arranged not only in the area of the crossbeam 12, but also in the front skirt 18 and the side area. The protrusion 13 can be configured in a T-shape. Thereby, the protrusion 13 can firmly fix the adhesive layer like a bollard for tying a ship's rope.
[0029] In order to fix the main structure 1 on the skull, a plurality of first holes 14 are provided in the main structure 1. The first holes 14 are configured to allow connecting screws to pass through. The connecting screws are configured to fix the main structure 1 on the skull by threaded connection. Figure 1 As shown, the first holes 14 are arranged not only in the region of the front skirt 18 of the main structure 1, but also in the intersection region of the crossbeam 12 and in the transition region from the crossbeam 12 to the side and in the rear region of the main structure 1. In other embodiments, other arrangements of the first holes 14 are also conceivable. For example, the first holes 14 can be arranged in the region of the front skirt 18 of the main structure 1, or in the intersection region of the crossbeam 12, or in the transition region from the crossbeam 12 to the side, or in the rear region of the main structure 1.
[0030] In order to fix the scalp of the non-human primate to the main structure 1, side skirts 15 are provided on both sides of the main structure 1. Second holes 16 are provided in the side skirts 15, and the second holes 16 are configured to allow surgical sutures to pass through so as to fix the scalp to the side skirts 15 by sewing. In addition to sewing, the scalp of the non-human primate can also be fixed to the side skirts 15 by other means. By fixing the main structure 1 to the scalp, the internal brain area can be protected from bacterial infection.
[0031] The main structure 1 is provided with external mounting holes 17 on both sides and / or in the rear central area, and the external mounting holes 17 are used to install other accessories and / or pass the electrode wire. For example, the other accessories may be a helmet.
[0032] The main structure 1 can be fixed on the skull 3 of a non-human primate. The inner surface of the main structure 1 can be fitted with the skull as described above. After fitting, the main structure 1 can be fixed to the skull by connecting screws. After a craniotomy is performed on a specific brain area through the corresponding window 11, the window 11 can be covered by a cover 2 matched with the window 11 to protect the internal brain area from infection or damage.
[0033] It should be noted that the terms used herein are for the purpose of illustrating specific aspects only and are not intended to limit the disclosure. As used herein, the singular forms "a" and "the one" shall include the plural forms unless the context clearly states otherwise. It is understood that the terms "include" and "comprises" and other similar terms, when used in the application documents, specify the existence of the stated operations, elements and / or parts, without excluding the existence or addition of one or more other operations, elements, parts and / or combinations thereof. As used herein, the term "and / or" includes all arbitrary combinations of one or more related enumerated items. In the description of the drawings, similar reference numerals always represent similar elements.
[0034] The thickness of the elements in the accompanying drawings can be exaggerated for the sake of clarity. It is also understood that if an element is referred to as being on another element, coupled to another element or connected to another element, then the element can be directly formed on the other element, coupled to it or connected to it, or one or more intervening elements can be arranged between them. On the contrary, if the expressions "directly on...", "directly coupled to..." and "directly connected to..." are used herein, then there is no intervening element. Other words used to illustrate the relationship between elements should be similarly interpreted, such as "between..." and "directly between...", "attachment" and "direct attachment", "adjacent" and "directly adjacent", etc.
[0035] Terms such as "top," "bottom," "above," "below," "above," "below," etc. are used herein to describe the relationship of one element, layer or region to another element, layer or region as illustrated in the drawings. It will be understood that these terms are intended to encompass other orientations of the device in addition to the orientation depicted in the drawings.
[0036] It is to be understood that although the terms "first", "second", etc. may be used herein to describe different elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another element. Therefore, the first element may be referred to as the second element without departing from the teachings of the present invention.
[0037] It is also conceivable that all exemplary embodiments disclosed herein can be combined with one another in any desired manner.
[0038] Finally, it should be pointed out that the above embodiments are only used to understand the present invention, and do not limit the protection scope of the present invention. For those skilled in the art, modifications can be made based on the above embodiments, and these modifications do not depart from the protection scope of the present invention.
Claims
1. A brain region division device, the brain region division device is configured to divide the craniotomy area according to different brain regions of a non-human primate so as to be able to perform craniotomy on the corresponding required brain region, characterized in that: The brain region division device includes a main structure, which can be fixed on the skull of a non-human primate. A plurality of windows for specifying craniotomy areas are arranged in the main structure. The respective sizes and positions of the plurality of windows correspond to different brain regions of the non-human primate, and cross beams for reinforcement and separation are arranged between the windows.
2. The brain region division device according to claim 1, characterized in that: At least some of the plurality of windows are arranged symmetrically about the longitudinal center axis of the main structure.
3. The brain region division device according to claim 1 or 2, characterized in that: The brain region division device also includes a covering member, and each window in the main structure is respectively equipped with a covering member, and the covering member is configured to cover the window corresponding to the brain region after a craniotomy is performed on the corresponding brain region.
4. The brain region division device according to claim 3, characterized in that: The size of the outer periphery of the cover matches the size of the inner periphery of the corresponding window.
5. The brain region division device according to claim 3, characterized in that: The cover is configured to be fixed to the window by an adhesive layer, and at least a portion of the adhesive layer is disposed between an outer peripheral portion of the cover and an inner peripheral portion of the corresponding window.
6. The brain region division device according to claim 5, characterized in that: A protrusion is provided on the section of the main structure surrounding the window, and the protrusion is configured to additionally fix the adhesive layer, wherein the adhesive layer is configured to extend beyond the window area and a portion of the adhesive layer is configured to be arranged around the protrusion so as to be additionally fixed to the protrusion.
7. The brain region division device according to claim 6, characterized in that: The projection is configured in a T-shape.
8. The brain region division device according to claim 1 or 2, characterized in that: A plurality of first holes are arranged in the main structure. The first holes are configured to allow connecting screws to pass through. The connecting screws are configured to fix the main structure to the skull by threaded connection.
9. The brain region division device according to claim 8, characterized in that: The first opening is arranged in the region of the front skirt of the main structure and / or in the intersection region of the crossbeam and / or in the transition region of the crossbeam to the side edge and / or in the rear region of the main structure.
10. The brain region division device according to claim 1 or 2, characterized in that: The geometric structure of the inner surface of the main structure is adapted to the geometric structure of the outer surface of the skull of the non-human primate, so that the main structure can fit on the skull of the non-human primate when fixed.
11. The brain region division device according to claim 1 or 2, characterized in that: Side skirts are arranged on both sides of the main structure, and the side skirts are used to fix the scalp of a non-human primate to the main structure.
12. The brain region division device according to claim 11, characterized in that: A second hole is provided in the side skirt, and the second hole is configured to pass a surgical suture through so as to fix the scalp to the side skirt by sewing.
13. The brain region division device according to claim 1 or 2, characterized in that: The main structure is provided with external mounting holes on both sides and / or an external mounting hole in the central area of the rear portion, and the external mounting holes are used for installing other accessories and / or for passing the electrode wire.
14. The brain region division device according to claim 1 or 2, characterized in that: The main structure is constructed in one piece.