Preparation method of taurine solid beverage

Abstract

The invention relates to a preparation method of a taurine solid beverage. The taurine solid beverage is an effervescent tablet solid beverage and is prepared from active ingredients, an effervescing agent, a filling agent, a sweetening agent, a flavoring agent, an adhesive, a lubricating agent, glucosyl-beta-cyclodextrin, EDTA (Ethylene Diamine Tetraacetic Acid) and a moisture-proof agent, the active ingredients comprise taurine, vitamin C, potassium chloride and zinc glycinate; the effervescing agent comprises an acidic effervescing agent and an alkaline effervescing agent, the acidic effervescing agent is citric acid, and the alkaline effervescing agent is sodium bicarbonate; the filling agent is sodium carboxymethyl cellulose and mannitol; the sweetening agent is aspartame and xylitol; the flavoring agent is apple essence; the adhesive is a 10wt% polyvinylpyrrolidone K60 absolute ethyl alcohol solution; the lubricant is a 10wt% polyethylene glycol 6000 absolute ethyl alcohol solution; the moisture-proof agent is a 1.25 wt% high methoxyl pectin aqueous solution containing 0.5 vol% of glycerol. The solid beverage is convenient to use, good in taste, high in stability, high in dissolving speed and high in antioxidant activity.

Description

Technical Field

[0001] The invention belongs to the technical field of solid beverages, and in particular relates to a preparation method of a taurine solid beverage. Background Art

[0002] Taurine, also known as taurine, taurine bile acid, taurine choline, and taurine bile, is a white crystal or crystalline powder. It is a sulfur-containing non-protein amino acid with a chemical name of 2-aminoethanesulfonic acid and a chemical formula of C2H7NO3S. In most cases, taurine exists in a free form. Although it does not participate in the biosynthesis of proteins in the body, it plays an important physiological function in the body. Studies have shown that taurine has a wide range of effects. It can promote the brain development and intellectual development of infants and young children, maintain normal visual function, treat cardiovascular diseases such as heart failure, promote the digestion and absorption of lipids, relieve fatigue, enhance immunity, improve endocrine status, lower blood sugar, prevent cataracts, improve memory, and resist aging. With the continuous improvement of people's living standards and the enhancement of health awareness, taurine is widely used in various health foods and has become one of the important raw materials for health foods.

[0003] Solid beverages are a new form of health food. They refer to beverages that are made by mixing, concentrating, and drying various raw materials (such as plant extracts, sugar, juice, and other ingredients), or crushing and mixing various raw materials into granular, flake, or powdered form, and can only be drunk after being mixed with water. Compared with traditional forms of health food, health food in the form of solid beverages has the advantages of being easy to take orally, easy to carry, good taste, not easy to deteriorate, and easy to store, which can meet people's daily nutritional needs. [Xu Zuoyan. Research on the application progress of taurine in health food. China Food Industry, 2024(3): 102-104.] The distribution of taurine-containing health food dosage forms was investigated. The results showed that considering the solubility, stability, and performance of taurine, the most common health food containing taurine is in the form of capsules, while there are relatively few products in the form of solid beverages. Faced with the increasingly fast pace of modern life, consumers prefer a convenient and ready-to-eat mode of consumption. Taurine-containing health food in the form of solid beverages is becoming more and more popular. However, there are various preparation methods for taurine-containing health foods in the form of solid beverages. Differences in preparation processes and formulas result in uneven quality of products such as taste, solubility, stability, etc. Therefore, it is necessary to improve the preparation method, improve the quality of the product, adapt to the requirements of large-scale production, and meet the health needs of consumers. Summary of the invention

[0004] In view of the above problems, the present invention aims to provide a method for preparing a taurine solid beverage.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is as follows: A method for preparing a taurine solid beverage comprises the following steps: S1: Weigh glucosyl-β-cyclodextrin, add pure water at 40°C, and ultrasonicate to make it into a saturated solution; add taurine and vitamin C to the saturated solution of glucosyl-β-cyclodextrin, shake and react at 40°C for 72 hours, then centrifuge for 30 minutes, filter out the precipitate with a polypropylene filter with a pore size of 0.45 μm, and vacuum dry the filtrate at 60°C to obtain a solid, which is crushed and passed through a 100-mesh sieve to obtain an active ingredient mixture; S2: The active ingredient mixture obtained in step S1 is mixed with potassium chloride, zinc glycinate, acidic effervescent agent, alkaline effervescent agent, filler, sweetener, flavoring agent, EDTA and lubricant, the mixture is sieved through a 100-mesh sieve, a binder is added and mixed evenly, granulated by a rocking granulator, vacuum dried at 60° C. to obtain dry granules, and granulated to 20 mesh size before tableting to obtain tablets; S3: spray a layer of moisture-proof agent on the surface of the tablet obtained in step S2, and dry it to obtain a taurine effervescent tablet solid beverage.

[0006] In the above step S1, the amount of glucosyl-β-cyclodextrin is 28 parts by weight, the amount of taurine is 2 parts by weight, and the amount of vitamin C is 0.1 parts by weight; In the above step S2, the amount of potassium chloride is 0.1 parts by weight, the amount of zinc glycinate is 0.1 parts by weight, the amount of the acidic effervescent agent is 500 parts by weight, the amount of the alkaline effervescent agent is 800 parts by weight, the amount of the filler is 600 parts by weight, the amount of the sweetener is 200 parts by weight, the amount of the flavoring agent is 50 parts by weight, the amount of EDTA is 50 parts by weight, the amount of the lubricant is 1200 parts by weight, and the amount of the adhesive is 200 parts by weight; The acidic effervescent agent is citric acid, the alkaline effervescent agent is sodium bicarbonate, the filler is sodium carboxymethyl cellulose and mannitol in a mass ratio of 1:1, the sweetener is aspartame and xylitol in a mass ratio of 1:1, the flavoring agent is apple flavor, the lubricant is a 10wt% polyethylene glycol 6000 anhydrous ethanol solution, and the adhesive is a 10wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution.

[0007] In the above step S3, the weight ratio of the tablet to the moisture-proof agent is 100:1; The desiccant is a 1.25 wt % high methoxy pectin aqueous solution containing 0.5 vol % glycerol.

[0008] A taurine solid beverage prepared by the above preparation method.

[0009] The significant advantages of the present invention are: The taurine effervescent tablet solid beverage of the present invention has good taste when taken, and is convenient to carry and drink. The effervescent tablet has a short disintegration time, can be quickly dissolved, is not easy to absorb moisture during production and storage, has good stability, and has good antioxidant activity as confirmed by antioxidant experiments. DETAILED DESCRIPTION

[0010] In order to make the contents of the present invention easier to understand, the technical solution of the present invention is further described below in conjunction with specific implementation methods, but the present invention is not limited thereto.

[0011] Embodiment 1: This embodiment provides a method for preparing a taurine effervescent tablet solid beverage, comprising the following steps: S1: Weigh 28 parts by weight of glucosyl-β-cyclodextrin, add pure water at 40°C, and ultrasonicate to make it into a saturated solution; slowly add 2 parts by weight of taurine and 0.1 parts by weight of vitamin C to the saturated solution of glucosyl-β-cyclodextrin, shake and react at 40°C and 500 r / min for 72 hours, then centrifuge at 2000 rpm for 30 minutes, filter out the precipitate with a polypropylene filter with a pore size of 0.45 μm, and vacuum dry the filtrate at 60°C for 24 hours to obtain a solid, which is crushed and passed through a 100-mesh sieve to obtain an active ingredient mixture; S2: the active ingredient mixture obtained in step S1 is mixed evenly with 0.1 parts by weight of potassium chloride, 0.1 parts by weight of zinc glycinate, 500 parts by weight of citric acid, 800 parts by weight of sodium bicarbonate, 300 parts by weight of sodium carboxymethyl cellulose, 300 parts by weight of mannitol, 100 parts by weight of aspartame, 100 parts by weight of xylitol, 50 parts by weight of apple flavor, 50 parts by weight of EDTA and 1200 parts by weight of 10 wt% polyethylene glycol 6000 anhydrous ethanol solution, the mixture is sieved through a 100-mesh sieve, 200 parts by weight of 10 wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution is added and mixed evenly, granulated by a rocking granulator, vacuum dried at 60° C. for 12 h to obtain dry granules, and granulated to 20 mesh size to obtain tablets; S3: spray a layer of 1.25wt% high methoxy pectin aqueous solution containing 0.5vol% glycerol on the surface of the tablet obtained in step S2, the weight ratio of tablet: 1.25wt% high methoxy pectin aqueous solution containing 0.5vol% glycerol is 100:1, dry in the air, and obtain a taurine effervescent tablet solid beverage.

[0012] The taurine effervescent tablet solid beverage of this example was added to drinking water, and 10 sensory assessors who had received sensory training were invited to conduct a sensory evaluation. The results showed that the solid beverage had a moderate sweet and sour taste, a strong apple flavor, was refreshing and delicious, and the liquid was clear without precipitation.

[0013] Comparative Example 1: This comparative example provides a method for preparing a taurine effervescent tablet solid beverage, comprising the following steps: S1: 28 parts by weight of glucosyl-β-cyclodextrin, 2 parts by weight of taurine, 0.1 parts by weight of vitamin C, 0.1 parts by weight of potassium chloride, 0.1 parts by weight of zinc glycinate, 500 parts by weight of citric acid, 800 parts by weight of sodium bicarbonate, 300 parts by weight of sodium carboxymethyl cellulose, 300 parts by weight of mannitol, 100 parts by weight of aspartame, 100 parts by weight of xylitol, 50 parts by weight of apple flavor, 50 parts by weight of EDTA and 1200 parts by weight of 10 wt% polyethylene glycol 6000 anhydrous ethanol solution are mixed uniformly, the mixture is sieved through a 100-mesh sieve, 200 parts by weight of 10 wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution are added and mixed uniformly, granulated by a rocking granulator, vacuum dried at 60° C. for 12 h to obtain dry granules, and granulated to 20 mesh size to obtain tablets; S2: spray a layer of 1.25wt% high methoxy pectin aqueous solution containing 0.5vol% glycerol on the surface of the tablet obtained in step S1, the weight ratio of tablet: 1.25wt% high methoxy pectin aqueous solution containing 0.5vol% glycerol is 100:1, dry in the air, and obtain a taurine effervescent tablet solid beverage.

[0014] Comparative Example 2: This comparative example provides a method for preparing a taurine effervescent tablet solid beverage, comprising the following steps: S1: 2 parts by weight of taurine, 0.1 parts by weight of vitamin C, 0.1 parts by weight of potassium chloride, 0.1 parts by weight of zinc glycinate, 500 parts by weight of citric acid, 800 parts by weight of sodium bicarbonate, 300 parts by weight of sodium carboxymethyl cellulose, 300 parts by weight of mannitol, 100 parts by weight of aspartame, 100 parts by weight of xylitol, 50 parts by weight of apple flavor, 50 parts by weight of EDTA and 1200 parts by weight of 10 wt% polyethylene glycol 6000 anhydrous ethanol solution are mixed uniformly, the mixture is sieved through a 100-mesh sieve, 200 parts by weight of 10 wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution are added and mixed uniformly, granulated by a rocking granulator, vacuum dried at 60° C. for 12 h to obtain dry granules, and granulated to 20 mesh size to obtain tablets; S2: spray a layer of 1.25wt% high methoxy pectin aqueous solution containing 0.5vol% glycerol on the surface of the tablet obtained in step S1, the weight ratio of tablet: 1.25wt% high methoxy pectin aqueous solution containing 0.5vol% glycerol is 100:1, dry in the air, and obtain a taurine effervescent tablet solid beverage.

[0015] Comparative Example 3: This comparative example provides a method for preparing a taurine effervescent tablet solid beverage, comprising the following steps: S1: Weigh 28 parts by weight of glucosyl-β-cyclodextrin, add pure water at 40°C, and ultrasonicate to make it into a saturated solution; slowly add 2 parts by weight of taurine and 0.1 parts by weight of vitamin C to the saturated solution of glucosyl-β-cyclodextrin, shake and react at 40°C and 500 r / min for 72 hours, then centrifuge at 2000 rpm for 30 minutes, filter out the precipitate with a polypropylene filter with a pore size of 0.45 μm, and vacuum dry the filtrate at 60°C for 24 hours to obtain a solid, which is crushed and passed through a 100-mesh sieve to obtain an active ingredient mixture; S2: the active ingredient mixture obtained in step S1 is mixed evenly with 0.1 parts by weight of potassium chloride, 0.1 parts by weight of zinc glycinate, 500 parts by weight of citric acid, 800 parts by weight of sodium bicarbonate, 300 parts by weight of sodium carboxymethyl cellulose, 300 parts by weight of mannitol, 100 parts by weight of aspartame, 100 parts by weight of xylitol, 50 parts by weight of apple flavor and 1200 parts by weight of 10 wt% polyethylene glycol 6000 anhydrous ethanol solution, the mixture is sieved through a 100-mesh sieve, 200 parts by weight of 10 wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution is added and mixed evenly, granulated by a rocking granulator, vacuum dried at 60° C. for 12 h to obtain dry granules, and granulated to 20 mesh size to obtain tablets; S3: spray a layer of 1.25wt% high methoxy pectin aqueous solution containing 0.5vol% glycerol on the surface of the tablet obtained in step S2, the weight ratio of tablet: 1.25wt% high methoxy pectin aqueous solution containing 0.5vol% glycerol is 100:1, dry in the air, and obtain a taurine effervescent tablet solid beverage.

[0016] Comparative Example 4: This comparative example provides a method for preparing a taurine effervescent tablet solid beverage, comprising the following steps: S1: Weigh 28 parts by weight of glucosyl-β-cyclodextrin, add pure water at 40°C, and ultrasonicate to make it into a saturated solution; slowly add 2 parts by weight of taurine and 0.1 parts by weight of vitamin C to the saturated solution of glucosyl-β-cyclodextrin, shake and react at 40°C and 500 r / min for 72 hours, then centrifuge at 2000 rpm for 30 minutes, filter out the precipitate with a polypropylene filter with a pore size of 0.45 μm, and vacuum dry the filtrate at 60°C for 24 hours to obtain a solid, which is crushed and passed through a 100-mesh sieve to obtain an active ingredient mixture; S2: The active ingredient mixture obtained in step S1 is mixed evenly with 0.1 parts by weight of potassium chloride, 0.1 parts by weight of zinc glycinate, 500 parts by weight of citric acid, 800 parts by weight of sodium bicarbonate, 300 parts by weight of sodium carboxymethyl cellulose, 300 parts by weight of mannitol, 100 parts by weight of aspartame, 100 parts by weight of xylitol, 50 parts by weight of apple flavor, 50 parts by weight of EDTA and 1200 parts by weight of 10 wt% polyethylene glycol 6000 anhydrous ethanol solution, the mixture is sieved through a 100-mesh sieve, 200 parts by weight of 10 wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution is added and mixed evenly, granulated by a rocking granulator, vacuum dried at 60° C. for 12 h to obtain dry granules, and 20-mesh granules are sized to obtain tablets, which are taurine effervescent tablets solid beverages.

[0017] Comparative Example 5: This comparative example provides a method for preparing a taurine effervescent tablet solid beverage, comprising the following steps: S1: Weigh 28 parts by weight of glucosyl-β-cyclodextrin, add pure water at 40°C, and ultrasonicate to make it into a saturated solution; slowly add 2 parts by weight of taurine and 0.1 parts by weight of vitamin C to the saturated solution of glucosyl-β-cyclodextrin, shake and react at 40°C and 500 r / min for 72 hours, then centrifuge at 2000 rpm for 30 minutes, filter out the precipitate with a polypropylene filter with a pore size of 0.45 μm, and vacuum dry the filtrate at 60°C for 24 hours to obtain a solid, which is crushed and passed through a 100-mesh sieve to obtain an active ingredient mixture; S2: the active ingredient mixture obtained in step S1 is mixed evenly with 0.1 parts by weight of potassium chloride, 0.1 parts by weight of zinc glycinate, 500 parts by weight of citric acid, 800 parts by weight of sodium bicarbonate, 300 parts by weight of sodium carboxymethyl cellulose, 300 parts by weight of mannitol, 100 parts by weight of aspartame, 100 parts by weight of xylitol, 50 parts by weight of apple flavor, 50 parts by weight of EDTA and 1200 parts by weight of 10 wt% polyethylene glycol 6000 anhydrous ethanol solution, the mixture is sieved through a 100-mesh sieve, 200 parts by weight of 10 wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution is added and mixed evenly, granulated by a rocking granulator, vacuum dried at 60° C. for 12 h to obtain dry granules, and granulated to 20 mesh size to obtain tablets; S3: Spray a layer of 1.25wt% gelatin solution containing 0.5vol% glycerol on the surface of the tablet obtained in step S2, the weight ratio of tablet: 1.25wt% gelatin aqueous solution containing 0.5vol% glycerol is 100:1, dry in the air, and obtain a taurine effervescent tablet solid beverage.

[0018] Comparative Example 6: This comparative example provides a method for preparing a taurine effervescent tablet solid beverage, comprising the following steps: S1: Weigh 28 parts by weight of glucosyl-β-cyclodextrin, add pure water at 40°C, and ultrasonicate to make it into a saturated solution; slowly add 2 parts by weight of taurine and 0.1 parts by weight of vitamin C to the saturated solution of glucosyl-β-cyclodextrin, shake and react at 40°C and 500 r / min for 72 hours, then centrifuge at 2000 rpm for 30 minutes, filter out the precipitate with a polypropylene filter with a pore size of 0.45 μm, and vacuum dry the filtrate at 60°C for 24 hours to obtain a solid, which is crushed and passed through a 100-mesh sieve to obtain an active ingredient mixture; S2: the active ingredient mixture obtained in step S1 is mixed evenly with 0.1 parts by weight of potassium chloride, 0.1 parts by weight of zinc glycinate, 500 parts by weight of citric acid, 800 parts by weight of sodium bicarbonate, 300 parts by weight of sodium carboxymethyl cellulose, 300 parts by weight of mannitol, 100 parts by weight of aspartame, 100 parts by weight of xylitol, 50 parts by weight of apple flavor, 50 parts by weight of EDTA and 1200 parts by weight of 10 wt% polyethylene glycol 6000 anhydrous ethanol solution, the mixture is sieved through a 100-mesh sieve, 200 parts by weight of 10 wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution is added and mixed evenly, granulated by a rocking granulator, vacuum dried at 60° C. for 12 h to obtain dry granules, and granulated to 20 mesh size to obtain tablets; S3: spray a layer of 1.25wt% high methoxy pectin aqueous solution on the surface of the tablet obtained in step S2, the weight ratio of tablet to 1.25wt% high methoxy pectin aqueous solution being 100:1, and dry in the air to obtain a taurine effervescent tablet solid beverage.

[0019] The foaming amount of taurine effervescent tablet solid beverage was determined according to the foaming amount determination rules of the 2020 edition of the "Chinese Pharmacopoeia (Volume IV)", the disintegration time limit of taurine effervescent tablet solid beverage was determined according to the effervescent tablet disintegration time limit inspection method in the 2020 edition of the "Chinese Pharmacopoeia (Volume IV)", and the moisture absorption rate of taurine effervescent tablet solid beverage was determined according to the 2015 edition of the "Chinese Pharmacopoeia" Part IV General Chapter 9103 Drug Hygroscopicity Test Guidance Principles. The results are shown in the table below.

[0020] Table 1 Foaming volume, disintegration time, and moisture absorption rate measurement results (after 0 months of storage) Table 2 Results of foaming volume, disintegration time and moisture absorption rate (placed for 3 months) Antioxidant activity of taurine effervescent tablet solid beverage: Weigh 0.5g taurine effervescent tablet solid beverage, crush it, put it in a 50ml volumetric flask, dissolve it in 60% ethanol, make up to volume, shake it well and filter it. The filtrate is used as the test solution. Then refer to the literature [[1] Luo Ping, Shi Lisha, Liu Huazhong. Study on the antioxidant capacity of pitaya juice in vitro [J]. Guangdong Agricultural Science, 2013(20): 93-96; [2] Zhang Yunhe, Han Zhonghui, Gao Zhijiang, et al. Determination of in vitro antioxidant activity of Yunnan wild blueberry extract [J]. Food Science and Technology, 2014, 39(10): 249-253; [3] Li Guosheng, Zhang Weimin. Study on the antioxidant activity of polyphenol compounds in pitaya flower [J]. Tropical Agricultural Science, 2016, 36(2): 5-10] to calculate its scavenging rate (%) for hydroxyl free radicals, DPPH free radicals and superoxide anion free radicals. The results are shown in the table below.

[0021] Table 3 Results of scavenging rates of hydroxyl radicals, DPPH radicals and superoxide anion radicals (0 months) Table 4 Results of scavenging rates of hydroxyl radicals, DPPH radicals and superoxide anion radicals (placed for 3 months) The above description is only a preferred embodiment of the present invention. All equivalent changes and modifications made according to the scope of the patent application of the present invention should fall within the scope of the present invention.

Claims

1. A method for preparing a taurine solid beverage, characterized in that: The following steps are involved: S1: Weigh glucosyl-β-cyclodextrin, add pure water at 40°C, and ultrasonicate to make it into a saturated solution; add taurine and vitamin C to the saturated solution of glucosyl-β-cyclodextrin, shake and react at 40°C for 72 hours, then centrifuge for 30 minutes, filter out the precipitate with a polypropylene filter with a pore size of 0.45 μm, and vacuum dry the filtrate at 60°C to obtain a solid, which is crushed and passed through a 100-mesh sieve to obtain an active ingredient mixture; S2: The active ingredient mixture obtained in step S1 is mixed with potassium chloride, zinc glycinate, acidic effervescent agent, alkaline effervescent agent, filler, sweetener, flavoring agent, EDTA and lubricant, the mixture is sieved through a 100-mesh sieve, a binder is added and mixed evenly, granulated by a rocking granulator, vacuum dried at 60° C. to obtain dry granules, and granulated to 20 mesh size before tableting to obtain tablets; S3: spray a layer of moisture-proof agent on the surface of the tablet obtained in step S2, and dry it to obtain a taurine effervescent tablet solid beverage.

2. The preparation method according to claim 1, characterized in that: In step S1, the amount of glucosyl-β-cyclodextrin is 28 parts by weight, the amount of taurine is 2 parts by weight, and the amount of vitamin C is 0.1 parts by weight.

3. The preparation method according to claim 1, characterized in that: In step S2, the amount of potassium chloride is 0.1 parts by weight, the amount of zinc glycinate is 0.1 parts by weight, the amount of the acidic effervescent agent is 500 parts by weight, the amount of the alkaline effervescent agent is 800 parts by weight, the amount of the filler is 600 parts by weight, the amount of the sweetener is 200 parts by weight, the amount of the flavoring agent is 50 parts by weight, the amount of EDTA is 50 parts by weight, the amount of the lubricant is 1200 parts by weight, and the amount of the adhesive is 200 parts by weight.

4. The preparation method according to claim 3, characterized in that: The acidic effervescent agent is citric acid, the alkaline effervescent agent is sodium bicarbonate, the filler is sodium carboxymethyl cellulose and mannitol in a mass ratio of 1:1, the sweetener is aspartame and xylitol in a mass ratio of 1:1, the flavoring agent is apple flavor, the lubricant is a 10wt% polyethylene glycol 6000 anhydrous ethanol solution, and the adhesive is a 10wt% polyvinyl pyrrolidone-K60 anhydrous ethanol solution.

5. The preparation method according to claim 1, characterized in that: In step S3, the weight ratio of the tablet to the moisture-proof agent is 100:

1.

6. The preparation method according to claim 5, characterized in that: The moisture-proof agent is a 1.25 wt % high methoxy pectin aqueous solution containing 0.5 vol % glycerol.

7. A taurine solid beverage prepared by the preparation method according to any one of claims 1 to 6.

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