Composition for removing red blood streaks and improving skin barrier and application thereof

Abstract

The invention discloses a composition for removing red blood streaks and improving skin barrier and application thereof, belonging to the field of daily necessities. The product is prepared by combining a variety of natural plant ingredients such as camellia seed oils and iris extracts. Through the synergistic effect of these components, when acting on red blood streaked skin, the cold sensors in the skin can be effectively activated and the heat sensors can be inhibited, so as to relieve the burning sensation of the skin, promote capillary microcirculation, dredge congestion, improve the red blood streak phenomenon, and at the same time repair the skin barrier, increase skin tolerance, and improve the wrinkle phenomenon caused by insufficient blood supply to the capillaries.

Description

Technical Field

[0001] The invention relates to the field of daily necessities, and in particular to a composition for removing red blood streaks and improving skin barrier and an application thereof. Background Art

[0002] The obvious red blood streaks on human skin, especially on the face, are generally called blood streak erythema. They are mainly caused by the dilation of capillaries in the skin, or the local heating of the skin caused by the shallow location of capillaries. This phenomenon usually occurs in people with sensitive skin, when they are emotionally excited, when the external temperature suddenly changes (for example, when you suddenly enter a heated room from a cold outdoor), or when the skin is stimulated by the outside world. When it appears, people will feel the skin is hot and itchy. If not handled properly, it will not only be difficult to relieve, but also form pigmentation, affecting skin health.

[0003] Currently, the main treatment products for this type of symptoms are mostly hormone drugs, which have large side effects. Some skin care products that constrict skin blood vessels and promote vascular microcirculation can improve the red blood streak phenomenon to a certain extent. However, if you simply constrict the blood vessels, the capillaries in the skin will still generate heat at a high speed, and the nerve endings will be overactive, causing the peripheral blood vessels to continue to expand and even rupture, congestion and blockage, and the obvious burning sensation on the skin will not be relieved. Summary of the invention

[0004] Based on the defects of the prior art, the purpose of the present invention is to provide a composition for removing red blood streaks and improving skin barrier. The product is formulated by combining a variety of natural plant ingredients such as camellia seed oil and iris extract. Through the combined action of these components, when acting on skin with red blood streaks, it can effectively activate the cold sensors and inhibit the heat sensors in the skin, relieve the burning sensation of the skin, promote capillary microcirculation, dredge congestion, improve the red blood streak phenomenon, and at the same time repair the skin barrier, increase skin tolerance, and improve the wrinkles caused by insufficient blood supply to the capillaries.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is:

[0006] A composition for removing red blood streaks and improving skin barrier, comprising the following components in parts by weight:

[0007] 1-5 parts of camellia seed oil, 1-3 parts of iris extract, 1-3 parts of saffron extract, 1-3 parts of hydrolyzed vegetable protein, and 0.5-1.5 parts of ascorbic acid peptide.

[0008] Traditional skin care products for removing red blood streaks generally remove red blood streaks by acting on the skin with active substances that constrict capillaries and increase microcirculation. However, this approach cannot relieve the heat generated by the capillaries. The nerve endings are highly active, and people do not experience the burning sensation on their faces after using such products. The contraction of capillaries may even cause blood vessel rupture, congestion, and more obvious erythema symptoms. To this end, the technical solution of the present invention provides a composition with multiple mechanisms of action for removing red blood streaks and improving skin barrier. Among the components of this product, camellia seed oil is rich in active ingredients with skin care functions, such as unsaturated oleic acid, triterpenoid alcohols, polyphenols, squalene, etc., and has antibacterial and anti-inflammatory effects when used alone; white lily extract contains a large amount of saponins and polyphenol compounds, so it is often used as a traditional Chinese medicine ingredient and has a certain edema relief effect; the main component of saffron extract is glycosylated flavonoids, which is a type of plant extract with obvious analgesic effect; hydrolyzed plant protein is a common additive in existing skin care products, which has the effect of promoting metabolism on the skin surface; ascorbic acid polypeptide is a skin care active substance that combines polypeptide molecules and ascorbic acid, taking into account the whitening + anti-aging functions of both, and the inventor accidentally discovered after a large number of experiments that these substances in a specific proportion The combination can show significant effects of soothing the skin and removing red blood streak symptoms. The main reason is that this combination can activate the cold-sensing channel TRPM8 in the keratinocytes of human skin and inhibit the heat-sensing channel TRPV1 when used. The expression levels of the two channels change significantly in the opposite direction, thereby eliminating the stimulation of external or environmental factors on the skin from the somatic sense, playing a calming and soothing effect, and making the skin surface produce a "cool" and comfortable feeling. At the same time, it can also promote capillary microcirculation, so that the blood vessels will not cause congestion, and the waste in the blood vessels can be quickly metabolized, and the symptoms of red blood streak are significantly removed; in addition, after use, the product can also repair the barrier damage caused by the skin's own circulation or external factors to a certain extent, thereby improving the skin's tolerance, replenishing water and anti-aging, and the symptoms of red blood streak are less likely to recur, and the side effects on the human body are small.

[0009] Preferably, the weight proportion of the camellia oil is within the range of one or any two of 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, and 5 parts.

[0010] Preferably, the weight portion of the white mulberry extract is one of 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts or any two of the range values; the weight portion of the saffron extract is one of 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts or any two of the range values; the weight portion of the hydrolyzed lupin protein is one of 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts or any two of the range values; the weight portion of the anti-hemoglobin polypeptide is one of 0.5 parts, 0.8 parts, 1 part, 1.2 parts, 1.5 parts or any two of the range values.

[0011] Preferably, the mass ratio of the total mass of the Bletilla striata extract, the saffron extract, the hydrolyzed vegetable protein and the ascorbic acid polypeptide to the camellia seed oil is (3.5-4.5):1.

[0012] In addition to being rich in active ingredients, the camellia seed oil in the product of the present invention is itself an oil phase, and therefore has a certain solubility for oil-soluble active substances in other components. When the mass ratio of the camellia seed oil to other components in the composition of the present invention is preferably within the above range, these active substances dissolved in the camellia seed oil can better cooperate with oleic acid, polyphenols and other components in the camellia seed oil to act on the skin, so that the product is absorbed faster after contacting the skin and penetrates into the cold and hot sensors and capillaries to act, and the effect of soothing and removing the symptoms of red blood streaks is better.

[0013] More preferably, the mass ratio of the camellia seed oil to the total mass of the iris extract, saffron extract, hydrolyzed vegetable protein and ascorbic acid polypeptide is m(camellia seed oil):m(iris extract+saffron extract+hydrolyzed vegetable protein+ascorbic acid polypeptide)=1:3.5, 1:3.8, 1:4, 1:4.2, 1:4.5, or any two of the range values.

[0014] More preferably, the mass ratio of the Oriole sibiricum extract, the Saffron saffron extract, the hydrolyzed vegetable protein and the ascorbic acid polypeptide is (1.5-2.5):(1.5-2.5):(1-1.5):(0.5-1).

[0015] After selecting a suitable ratio of oil phase and active ingredients, the inventors found through further experiments that when the ratio between the active ingredients is preferably within the above range, the product becomes effective faster after being used on the skin. The main reason may be that at the said ratio, the effective ingredients in these active ingredients can be better dispersed in camellia seed oil, the compatibility of the ingredients is higher, the synergistic effect is stronger, and the effect is naturally better when acting on the active sites of the sensor.

[0016] Preferably, the hydrolyzed vegetable protein comprises at least one of hydrolyzed lupin protein, hydrolyzed soy protein, hydrolyzed silk protein, hydrolyzed camellia seed protein, hydrolyzed rice bran protein, hydrolyzed wheat protein, hydrolyzed tea seed protein, and hydrolyzed seaweed protein.

[0017] More preferably, the hydrolyzed vegetable protein is hydrolyzed lupin protein.

[0018] Lupine is also known as lupine. The protein of this plant after hydrolysis has a good effect on repairing the skin. After experiments, the inventors found that compared with other hydrolyzed plant proteins such as hydrolyzed soy protein, the synergistic combination of hydrolyzed lupine protein in the composition for removing red blood streaks and improving skin barrier of the present invention has a better effect, and the effect of improving and repairing skin with red blood streaks is more significant.

[0019] Another object of the present invention is to provide a skin care cosmetic comprising the composition for removing red blood streaks and improving skin barrier of the present invention.

[0020] Preferably, the skin care cosmetics include any one of lotion, emulsion, cream, mask, essence, essence oil and spray.

[0021] The composition for removing red blood streaks and improving skin barrier of the present invention has high activity, strong functionality and high stability, and therefore can be processed into skin care cosmetic products with common dosage forms on the market. As long as the efficacy of the composition for removing red blood streaks and improving skin barrier is not affected, the type of skin care cosmetics containing the composition for removing red blood streaks and improving skin barrier is not restricted.

[0022] More preferably, the skin care cosmetic is an essence oil.

[0023] More preferably, the essence oil comprises the following components in parts by weight: 1 to 10 parts of a moisturizer, and 0.5 to 5 parts of the composition for removing redness and improving the skin barrier of the present invention.

[0024] The composition for removing red blood streaks and improving skin barrier of the present invention can not only effectively alleviate the erythema phenomenon and burning sensation caused by red blood streaks on the skin, but also effectively repair the skin barrier as mentioned above, and play a certain role in moisturizing, hydrating, anti-aging and anti-wrinkle. Therefore, when used to prepare skin care cosmetics similar to essence oils, it can be combined with a moisturizer to further enhance the moisturizing effect of the product, moisturize the skin, and enhance the skin's tolerance to external stimuli.

[0025] Preferably, the moisturizing agent includes at least one of glycerin, D-panthenol, vitamin B5, 1,3-butylene glycol, 1,2-hexanediol, 1,3-propylene glycol, sodium hyaluronate, tremella polysaccharide, trehalose, betaine and squalane.

[0026] More preferably, in the essence oil, the weight proportion of the composition for removing red blood streaks and improving skin barrier is in the range of one or any two of 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5 parts.

[0027] Preferably, the essential oil is a water-oil biphase essential oil;

[0028] More preferably, the essence oil, based on 100 parts, comprises the following components in parts by weight: 1 to 10 parts of moisturizer, 0.5 to 5 parts of the composition for removing red blood streaks and improving skin barrier of the present invention, 1 to 10 parts of oil phase ingredients, 1 to 5 parts of preservatives, 0.01 to 0.1 parts of flavor and the balance in parts by weight of water.

[0029] It should be noted that the essence oil described in the present invention is not limited to the above-mentioned ingredients. It is well known to those skilled in the art that the technical effects of cosmetics and skin care products are generally reflected in skin care. Therefore, on the premise of ensuring the skin care effect, it is a routine operation to select different ingredient compositions based on the differences in different dosage forms. In the essence liquid described in the present invention, on the premise of ensuring that the composition for removing red blood streaks and improving skin barrier can exert normal effects, those skilled in the art can adjust the addition ratio of other ingredients according to actual production or use requirements, and can also add additional ingredients commonly used in skin care cosmetics such as antioxidants and colorants as needed (for example, part of the water in the above-mentioned essence oil formula can be replaced with an equal weight of antioxidants to improve the storage stability of the essence oil).

[0030] Preferably, the oil phase ingredients include at least one of ethylhexylglycerin, dimethicone, steareth-2, steareth, caprylic / capric triglyceride, polyglyceryl-6 polyricinoleate, C14-22 alkyl alcohol / C12-20 alkyl glucoside, polymethyl silsesquioxane, cetearyl glucoside, hydrogenated lecithin, triethylhexanoin, and isododecane.

[0031] Preferably, the preservative includes at least one of p-hydroxyacetophenone and a polyol; the polyol includes at least one of propylene glycol, pentylene glycol and hexylene glycol.

[0032] Further preferably, the method for preparing the essential oil comprises the following steps:

[0033] (1) heating the camellia seed oil and the oil phase components in the composition for removing red blood streaks and improving skin barrier to 70 to 90° C. and mixing them evenly to obtain phase I;

[0034] (2) uniformly mixing the other components of the composition for removing red blood streaks and improving skin barrier except camellia seed oil and the moisturizer to obtain phase II;

[0035] (3) The preservative is heated and added to phase I, mixed evenly, and then cooled. After the mixed phase is cooled to 40° C., it is added to phase II and mixed to obtain the essential oil.

[0036] The beneficial effect of the present invention is that the present invention provides a composition for removing red blood streaks and improving skin barrier. The product is formulated with a variety of natural plant ingredients such as camellia seed oils and iris extracts. Through the joint action of these components, when acting on red blood streaked skin, the cold sensors in the skin can be effectively and synchronously activated and the heat sensors in the skin can be inhibited, thereby relieving the burning sensation of the skin, promoting capillary microcirculation, unblocking congestion, and improving the red blood streak phenomenon. At the same time, the skin barrier can be repaired, the skin tolerance can be increased, and the wrinkles on the skin caused by insufficient blood supply to the capillaries can be improved.

[0037] Instruction Manual

[0038] Figure 1 This is a comparison of the red blood streaks on the face of a volunteer in Effect Example 2 of the present invention before and after using Essence Oil 1.

[0039] Figure 2 This is a comparison of the red blood streaks on the face of a volunteer in Effect Example 2 of the present invention before and after using the essence oil 31. DETAILED DESCRIPTION

[0040] In order to better illustrate the purpose, technical scheme and advantages of the present invention, the present invention will be further described in conjunction with specific examples and comparative examples. The purpose is to understand the content of the present invention in detail, rather than to limit the present invention. All other embodiments obtained by ordinary technicians in this field without creative work belong to the protection scope of the present invention. Unless otherwise specified, the experimental reagents and instruments involved in the implementation of the present invention are all commonly used ordinary reagents and instruments. Camellia seed oil is a product produced by Hunan Yamei Company, Baiwei extract is a product produced by RADIANT Company, saffron extract is a product produced by Youran Biotechnology Co., Ltd., hydrolyzed lupine protein is a product produced by Keyan Cosmetics Trading (Shanghai) Co., Ltd., hydrolyzed soy protein is a product produced by France Xianting Company, and ascorbic acid polypeptide is Vita Pep produced by Bioharvest Company. product.

[0041] Examples 1 to 17

[0042] The embodiments of the composition for removing red blood streaks and improving skin barrier and its application described in the present invention, the component compositions and proportions of each composition for removing red blood streaks and improving skin barrier are shown in Table 1.

[0043] Comparative Examples 1 to 14

[0044] A composition for removing red blood streaks and improving skin barrier, which differs from the embodiments only in that the components and proportions of the compositions for removing red blood streaks and improving skin barrier are different, as shown in Table 2.

[0045] Camellia extract is produced by Xi'an Ruilier Bioengineering Co., Ltd.

[0046] Jojoba seed oil is a product produced by Vantage Specialty Ingredients, Inc. of the United States;

[0047] Angelica dahurica extract is produced by Shanyang Lianfeng Biotechnology Co., Ltd.;

[0048] Ganoderma lucidum extract is produced by Shanyang Lianfeng Biotechnology Co., Ltd.;

[0049] Soy protein is a product produced by Xi'an Guohao Biotechnology Co., Ltd.;

[0050] Unless otherwise specified, the components and raw materials used in the embodiments and comparative examples of the present invention are all commercially available raw materials, and the components and raw materials used in each parallel experiment are all of the same kind.

[0051] Table 1

[0052]

[0053]

[0054] Table 2

[0055]

[0056] Effect Example 1

[0057] In order to explore the effect of the composition for removing red blood streaks and improving skin barrier of the present invention on inhibiting the red blood streak phenomenon, the products of each embodiment and comparative example were subjected to cell experiments:

[0058] Commercially available immortalized human keratinocytes (HaCaT) (lot number PN14) were inoculated into DMEM medium supplemented with 10% fetal bovine serum and 1% penicillin-streptomycin 100 μg / mL solution and cultured in an incubator at 37°C with 5% CO2. 3The cells were inoculated in a 48-well plate at a density of cells / well and cultured continuously; the cells were cultured in a cell culture dish with a diameter of 35 mm, and then 20 μL of the irritant capsaicin and the composition for removing red blood streaks and improving skin barrier prepared in each embodiment and comparative example (each component of each embodiment and comparative example product was mixed and then added with DMSO solvent and mixed evenly) were added to treat the cells for 48 hours, and the culture solution without the composition product was used as the control group. The cells were collected, the total RNA of the cells was extracted with TRIzol reagent, and then the cRNA was synthesized with the reverse transcription kit PrimeScript RT; then the relative quantitative analysis of the mRNA expression was performed using the CFX96 Touch Real-Time PCR detection system (Bio-Rad, Hercules, CA, USA), and the experimental conditions were: initial denaturation at 95°C for 5 minutes, followed by 40 cycles of 95°C / 15s, 60°C / 30s, and 72°C / 30s; after normalization to the GAPDH transcript level, the relative cDNA level was calculated using the 2-ΔΔCt method.

[0059] The gene expression rates of cold-sensing channel TRPM8 and heat-sensing channel TRPV1 were calculated respectively, gene expression rate (%) = (relative cDNA level of each gene in the blank group - relative cDNA level of each gene in the test group) / relative cDNA level of each gene in the blank group × 100%;

[0060] The higher the gene expression rate of the cell cold-sensing channel TRPM8 and the lower the expression of the heat-sensing channel TRPV1 in each group, the stronger the calming and soothing effect of the corresponding combination product. The test results are shown in Table 3.

[0061] Table 3

[0062]

[0063]

[0064] It can be clearly seen from Table 3 that the composition for removing red blood streaks and improving skin barrier of the present invention has obvious effects on the gene expression of TRPM8 and TRPV1, two cold and hot channels in cells, and has an activating effect on the gene expression of the former, while it has an inhibitory effect on the latter. After use, the TRPM8 gene expression rate of cells can reach more than 50%, while the TRPV1 gene expression rate can be controlled below 80%; among them, when the components of the products described in Examples 1 to 6 are matched, the ratio of camellia oil as the oil phase to other ingredients can be controlled in the range of 1:(3.5-4.5), and the ratio of the four ingredients of the white mulberry extract, the saffron extract, the hydrolyzed lupine protein and the ascorbic acid polypeptide is preferably in the range of (1.5-2.5):(1.5-2.5):(1-1.5):(0.5-1), the synergistic effect of the components is better, and the product has a better effect on the two channels.

[0065] In contrast, the addition ratio of each component in the products described in Comparative Examples 1 to 4 is not within the limited range of the formula of the present invention, the product components fail to exert an ideal matching effect, and the effect on the channel is not obvious; Camellia seed oil is not introduced into the product of Comparative Example 5, although the matching ratio of other components remains unchanged, the performance of the product is significantly reduced; on the other hand, in the case of only using camellia seed oil as the active ingredient in the product of Comparative Example 6, this component also has no sedative and soothing effect when used alone, indicating that these two types of components can only exert the expected efficacy when used in combination and in a reasonable ratio; Compared with Example 1, the products of Comparative Examples 7 to 8 lack saffron extract or ascorbic acid polypeptide respectively, while the ratio of oil phase to other ingredients remains unchanged. These two are not ingredients that have gene expression regulating effects on hot and cold channels in common knowledge, and the ratio between the remaining non-oil phase ingredients has not changed, but these two products do not show effects similar to those of the example products, which obviously shows that saffron extract and ascorbic acid polypeptide are necessary ingredients when the products work synergistically and are indispensable. If any component of the composition for removing red blood streaks and improving skin barrier of the present invention is replaced with other added active substances with similar chemical composition, as shown in Comparative Examples 10 to 14, in which Comparative Examples 10 and 11 replace camellia seed oil with camellia extract, which is also a product of the Theaceae plant, or with jojoba seed oil, a plant oil also commonly used in skin care products, the TRPM8 gene expression rate of the prepared products after use is only 36% at most, while the TRPV1 gene expression rate reaches 128%, indicating that when combined with other ingredients such as the iris extract, only the oil phase of camellia seed oil can achieve a synergistic effect; Comparative Example 1 Compared with Example 1, the product 2 replaces the white mulberry extract with the white angelica extract. Although white mulberry and white angelica are both common Chinese medicinal plants, and both are known in the field of traditional Chinese medicine to have similar effects of clearing heat and dispersing swelling, it can be seen from the test results of the product that in the composition system of the present invention, the white angelica extract cannot play the same matching effect as the white mulberry extract; similarly, in the comparative example 12 product, the saffron extract is replaced with the ganoderma lucidum extract, and the ascorbic acid polypeptide is replaced with the conventional ascorbic acid. The effects of the prepared products are not as good as those of the products of each embodiment, which fully illustrates the specificity of the selection of each component type in the composition product of the present invention. According to Example 1, Example 17 and Comparative Example 13, it can be seen that different plant-derived proteins have different regulating effects on the skin's cold and hot sensors when they are matched with other components in the composition for removing red blood streaks and improving skin barrier of the present invention. The inappropriate soy protein from plant sources cannot play the ideal effect, and among the hydrolyzed plant proteins, the use effect of hydrolyzed lupin protein is better.

[0066] In addition, the inventors also conducted comparative experiments on other hydrolyzed plant proteins, and the results showed that hydrolyzed lupin protein had the best effect, which will not be listed here one by one.

[0067] Effect Example 2

[0068] In order to verify the effect of removing red blood streak phenomenon by the actual application of the composition for removing red blood streak and improving skin barrier of the present invention, the composition for removing red blood streak and improving skin barrier prepared in each embodiment and comparative example was used according to the formula and preparation method in Table 4 to prepare skin care essence oils 1 to 31 (each essence oil used the composition for removing red blood streak and improving skin barrier obtained in Examples 1 to 17 and Comparative Examples 1 to 14 as an active ingredient in order), and at the same time, the composition for removing red blood streak and improving skin barrier obtained in Example 1 was used as an active ingredient to prepare essence oils 32 to 35 according to the formula in Table 4, which differed from essence oil 1 only in the weight parts of the composition for removing red blood streak and improving skin barrier. Essence oils 36 to 37 were prepared according to the formula in Table 4 using the composition for removing red blood streak and improving skin barrier obtained in Example 1 as an active ingredient, which differed from essence oil 1 only in the weight parts of each component.

[0069] Table 4

[0070]

[0071]

[0072] The preparation method of each essential oil is as follows:

[0073] (1) heating the camellia seed oil (or jojoba seed oil in the comparative product) and the oil phase components in the composition for removing red blood streaks and improving skin barrier to 80° C. and mixing them evenly to obtain phase I;

[0074] (2) uniformly mixing the other components of the composition for removing red blood streaks and improving skin barrier except camellia seed oil, the moisturizer and the essence to obtain phase II;

[0075] (3) The preservative is heated and added to phase I, mixed evenly, and then cooled. After the mixed phase is cooled to 40° C., it is added to phase II and mixed to obtain the essential oil.

[0076] Since the camellia extract in the product of Comparative Example 9 is not an oil phase component, it can be added in step (2) when preparing the essential oil.

[0077] Then, each essence oil 1 to 35 was tested on the volunteers’ skin:

[0078] 105 volunteers were recruited. On the day of the volunteer's visit, no product could be applied to the test area (arm). After washing the arm, the volunteers sat quietly in an air-conditioned room with a temperature of 21±1℃ and a humidity of 50±10% for 20 minutes. Then they were randomly divided into 35 groups, with 3 people in each group, corresponding to essential oils 1 to 35. The forearm of each volunteer (wrist to elbow joint) was evenly divided into 4 areas, and a 4*2.5cm area was randomly selected from the 4 areas in the middle of each volunteer's arm. 2 Use 3M medical tape to tear each area 5 times, then apply a patch soaked in 0.01% capsaicin solution, wait for 10 minutes, remove the patch, and wait another 10 minutes before using the transepidermal water loss probe to measure the skin's Hex (Courage + Khazaka) and color probe Colorimeter CL400 measure the initial TEWL value and initial a* value of each volunteer's test area, recorded as T0; then apply the patch stained with each group of essential oils according to the random table, remove the patch after 10 minutes of application, measure the TEWL value and a* value, recorded as T1; wait for another 20 minutes, measure the TEWL value and a* value, recorded as T2, and finally use the average value of the corresponding 12 test positions to calculate the improvement rate (%) of each test essential oil group after use according to the following formula. At the same time, a self-questionnaire survey was conducted on the burning sensation of the 4 test positions of the volunteer's arm after removing the patch for 20 minutes. Each essential oil has a total of 12 test positions, and each test position has a burning sensation of 1 point, and no burning sensation is 0 points, and the total score of the self-assessment of the burning sensation (self-perceived burning score) is calculated.

[0079] TEWL value improvement rate (%) = (initial TEWL average value - TEWL average value at each time point after use) / initial TEWL average value × 100%;

[0080] a* value improvement rate (%) = (initial a* average value - a* average value at each time point after use) / initial a* average value × 100%;

[0081] The greater the improvement rate of TEWL value, the stronger the ability of the essence oil to repair skin barrier damage; the greater the improvement rate of a* value, the stronger the ability of the essence oil to soothe and reduce redness. The smaller the total score of the self-assessment of burning sensation, the stronger the ability of the essence oil to reduce burning sensation, calm and soothe.

[0082] The test results are shown in Table 5.

[0083] Table 5

[0084]

[0085]

[0086] It can be seen from the test results that, similar to the results of the cell tests on the compositions for removing red blood streaks and improving skin barrier, after these products are prepared into essence oils, the essence oils corresponding to the products in each embodiment can effectively repair the skin barrier damaged by capsaicin stimulation after use, and play a significant soothing and redness-removing effect. The TEWL improvement rate of essence oils 1 to 17 products in the initial T1 stage can reach more than 12%, and the a* value improvement rate can reach 21% and above. At the same time, the efficacy of the essence oil is persistent. After 30 minutes of use, the corresponding TEWL improvement rate in the T2 stage is further increased to more than 37%, and the a* value improvement rate is increased to more than 51%. The use effect is very excellent. Among them, the essence oils 1 to 6 products prepared from the compositions for removing red blood streaks and improving skin barrier described in Examples 1 to 6 with the preferred ratio of oil phase to other ingredients have better use effects. At the same time, according to the comparison of the product effects of Essence Oil 1 and Essence Oils 32 to 35, it can be seen that the main functional component of the essence oil is the composition for removing red blood streaks and improving the skin barrier. Since the Essence Oil 32 product does not contain this ingredient, the skin barrier of the volunteers was not significantly repaired after use, and there was no corresponding soothing effect. As the amount of this ingredient added increased, the active effect of the essence oil on the skin also increased.

[0087] In contrast, the corresponding red blood streak removal and skin barrier improvement compositions in essence oils 18 to 31 were not configured according to the formula specified in the present invention, and did not exert sufficient improvement and repair effects in actual tests on volunteers, further verifying that if the red blood streak removal and skin barrier improvement compositions as the main functional ingredients are improperly formulated, the prepared essence oil products will not be able to obtain the ideal skin care and soothing functions.

[0088] By analyzing the self-perceived burning scores of the subjects, it can be seen that the skin burning sensation caused by the external force of the composition for removing red blood streaks and improving skin barrier has a strong short-term analgesic and soothing effect. Compared with the essence oil without the introduction of this component, 6 areas of the corresponding group 32 felt a burning sensation. The essence oil prepared by the composition product of each embodiment can completely eliminate the burning sensation only after 30 minutes of use. Once the ingredients or proportions are changed, the effect of soothing the burning sensation may be reduced, and the soothing feeling will decrease.

[0089] In order to further explore the effects of each essential oil, according to the results in Table 5, essential oil 1 and essential oils 17 to 32 were selected for further long-term volunteer use testing. 2) and 51 volunteers with sensitive skin with obvious red blood streaks. No products were applied to the test area (face) on the day of the visit. After washing the face, the volunteers sat quietly in an air-conditioned room with a temperature of 21±1℃ and a humidity of 50±10% for 20 minutes. Then they were randomly divided into 17 groups, with 3 people in each group, corresponding to the use of essence oil 1 and essence oils 17 to 32. Using the skin transepidermal water loss probe Hex (Courage + Khazaka) and color probe Colorimeter CL400 measured the initial TEWL value and initial a* value of the highest point of the cheekbones on the left and right cheeks of each volunteer. The VISIA7 device was used to take pictures of the volunteers' faces for wrinkle analysis. Each group of volunteers used the same amount of essence oil on their faces once in the morning and evening, and then measured the TEWL value, a* value and wrinkle value of the same facial skin at the 14th and 28th days respectively. The corresponding average values ​​were then used to calculate the respective improvement rates (%) according to the following formula:

[0090] TEWL value improvement rate (%) = (initial TEWL value - TEWL value after use) / initial TEWL value × 100%;

[0091] a* value improvement rate (%) = (initial a* value - a* value after use) / initial a* value × 100%;

[0092] Wrinkle improvement rate (%) = (initial wrinkle area - wrinkle area after use) / initial wrinkle area × 100% Among them, the greater the TEWL value improvement rate, the stronger the long-term repair ability of the essence for skin barrier damage; the greater the a* value improvement rate, the stronger the long-term soothing and redness-removing ability of the essence; the greater the wrinkle improvement rate, the better the anti-wrinkle effect of the essence oil.

[0093] The test results are shown in Table 6.

[0094] Table 6

[0095]

[0096]

[0097] It can be seen from the test results that under long-term use conditions, the essence oil of the present invention also has a good repair and relief effect on the skin barrier damage and red blood streaks formed on the facial skin over the years, and the improvement effect on the red blood streaks on the skin is very obvious. At the same time, based on the moisturizing and repairing effect of the composition in the essence oil, the wrinkles on the skin of the user will also be significantly improved after using the product. Figure 1 and 2As shown, after using the essence oil 1 product prepared with the composition for removing red blood streaks and improving the skin barrier, the red blood streaks on the faces of the volunteers were significantly improved compared to before use, while the red blood streak phenomenon of the volunteers did not change significantly before and after use of the essence oil 32 product which did not contain the composition for removing red blood streaks and improving the skin barrier.

[0098] In contrast, the essence oil products prepared in the comparative examples did not show a long-lasting skin care effect similar to that of essence oil 1. Similar to the short-term use experiment, in terms of TEWL improvement rate and a* value improvement rate, the essence oils prepared from some comparative examples did not even show obvious use activity, and in terms of improving red zones and eliminating wrinkles, such products were improperly formulated based on the red blood streak removal and skin barrier improvement compositions, and the components could not achieve synergistic enhancement, and therefore also failed to achieve the expected effect; although the essence oils prepared from some comparative examples showed relatively excellent anti-wrinkle effects, they were not ideal in terms of the red blood streak removal effect, indicating that not any combination of compositions can take into account the comprehensive improvement of the facial skin by the composition products of the embodiments of the present invention.

[0099] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A composition for removing red blood streaks and improving skin barrier, characterized in that: The composition is composed of the following components in parts by weight: 1-5 parts of camellia seed oil, 1-3 parts of iris extract, 1-3 parts of saffron extract, 1-3 parts of hydrolyzed vegetable protein, and 0.5-1.5 parts of ascorbic acid peptide.

2. The composition according to claim 1, characterized in that The mass ratio of the total mass of the iris extract, the saffron extract, the hydrolyzed plant protein and the ascorbic acid polypeptide to the camellia oil is (3.5-4.5):

1.

3. The composition according to claim 1, characterized in that The mass ratio of the white osmanthus extract, saffron extract, hydrolyzed vegetable protein and ascorbic acid polypeptide is (1.5-2.5):(1.5-2.5):(1-1.5):(0.5-1).

4. A skin care cosmetic, characterized in that: The invention comprises the composition according to any one of claims 1 to 3.

5. The skin care cosmetic according to claim 4, characterized in that: The skin care cosmetics are any one of lotion, emulsion, cream, facial mask, essence, essence oil and spray.

6. The skin care cosmetic according to claim 5, characterized in that: The skin care cosmetic is essence oil.

7. The skin care cosmetic according to claim 6, characterized in that: The essence oil comprises the following components in parts by weight: 1 to 10 parts of a moisturizer and 0.5 to 5 parts of the composition according to any one of claims 1 to 3.

8. The skin care cosmetic according to claim 7, characterized in that: The moisturizing agent includes at least one of glycerin, D-panthenol, vitamin B5, 1,3-butylene glycol, 1,2-hexanediol, 1,3-propylene glycol, sodium hyaluronate, tremella polysaccharide, trehalose, betaine and squalane.

9. The skin care cosmetic according to claim 6, characterized in that: The essential oil is a water-oil dual-phase essential oil; the essential oil, based on 100 parts, comprises the following components in parts by weight: 1 to 10 parts of a moisturizer, 0.5 to 5 parts of the composition according to any one of claims 1 to 3, 1 to 10 parts of an oil phase component, 1 to 5 parts of a preservative, 0.01 to 0.1 parts of an essence, and the balance in parts by weight of water.

10. The skin care cosmetic according to claim 9, characterized in that: The oil phase ingredients include at least one of ethylhexylglycerin, dimethicone, steareth-2, steareth, caprylic / capric triglyceride, polyglyceryl-6 polyricinoleate, C14-22 alkyl alcohol / C12-20 alkyl glucoside, polymethylsilsesquioxane, cetearyl glucoside, hydrogenated lecithin, triethylhexanoin, and isododecane, and / or the preservative includes at least one of p-hydroxyacetophenone and a polyol; the polyol includes at least one of propylene glycol, pentylene glycol, and hexylene glycol.

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