External traditional Chinese medicine preparation for treating diabetes and preparation method thereof

Abstract

The invention discloses an external compound preparation for treating diabetes mellitus, which comprises an agent A and an agent B. The agent A is used for meridian medication, the agent B is used for acupoint medication, and the problems that in the prior art, oral medication for treating diabetes mellitus has serious side effects on human bodies, and the curative effect is unstable are solved.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to a compound preparation for external use to treat diabetes and a preparation method thereof, especially to an application in the field of external use to treat diabetes. Background Art

[0002] Diabetes is a chronic disease characterized by hyperglycemia, which is caused by absolute or relative insufficient secretion of insulin and impaired utilization. The disease is mainly divided into type 1, type 2 and gestational diabetes, and the cause is mainly the combined effect of environmental and genetic factors. The symptoms of diabetes are mainly manifested as three more and one less, namely, polydipsia, polyuria, polyphagia and weight loss. In addition, patients with a long course of the disease may develop chronic progressive lesions, functional impairment or even failure of tissues and organs such as the eyes, kidneys, nerves, heart, and blood vessels, and may cause acute and severe metabolic disorders.

[0003] The cause of diabetes has not yet been elucidated. Different types of diabetes have different causes, even within the same type. Generally speaking, genetic and environmental factors contribute to the occurrence of diabetes. This is mainly due to the dysfunction of pancreatic cells leading to decreased insulin secretion, or the body's insensitivity to insulin, or both, which results in the inability to effectively utilize and store glucose in the blood. Diabetes has a certain genetic susceptibility and there is a family clustering phenomenon; according to epidemiological and clinical medical research, it has been made clear that the main cause of type 2 diabetes is related to an unhealthy lifestyle.

[0004] Studies have shown that type 1 and type 2 diabetes cannot be completely cured, and treatment aims to control the disease and prevent complications that seriously endanger the patient's health. Gestational diabetes is usually relieved after delivery.

[0005] Type 1 diabetes requires lifelong insulin regulation of blood sugar. Before the diagnosis of type 2 diabetes, blood sugar may return to normal through diet adjustment and exercise measures. However, for patients with long-term type 2 diabetes, lifestyle improvements cannot reverse the condition and lifelong medication is required. Most complications of diabetes are also difficult to cure, or progress slowly, or occur repeatedly.

[0006] Diabetes belongs to the category of thirst in traditional Chinese medicine. Traditional Chinese medicine believes that thirst mainly affects the lungs, stomach, and kidneys, and the basic cause is the loss of yin and fluid, and the excessive dryness and heat. If thirst lasts for a long time and the condition is out of control, the yin will damage the yang, the heat will burn the fluid and blood will stagnate, and the qi and yin will be injured, the yin and yang will be deficient, the collaterals will be blocked, the meridians will be malnourished, the qi and blood will be disordered, and the internal organs will be damaged, resulting in boils, carbuncles, dizziness, chest pain, deafness, blindness, limb pain, lower limb gangrene, renal failure edema, stroke coma and other complications. The thirst in traditional Chinese medicine was first established in "Huangdi Neijing. Qibing Lun", and was named thirst. According to traditional Chinese medicine, thirst is the upper thirst caused by lung heat damaging fluid, thirst and drinking a lot; the middle thirst caused by stomach fire burning and hunger; the kidney does not wade in water and urinates frequently, which is the lower thirst. Lung dryness, stomach heat, and kidney deficiency are seen together, or with one emphasis, and become thirst. The traditional Chinese medicine dialectical treatment of diabetes has a long history and is characterized by positive efficacy, few adverse reactions, and high patient acceptance. The traditional Chinese medicine treatment of diabetes has gradually developed from eating pears in ancient times to Chinese medicine decoctions to oral pills and external ointments, plasters, massage, acupuncture and other methods. With the diversification of treatment methods, different doctors carry out different treatment plans according to the patient's condition.

[0007] At present, the main methods of Western medicine for the treatment of diabetes are: oral medication, injection medication, metabolic surgery, pancreas and islet cell transplantation, stem cell therapy, etc. Oral medication and injection medication are currently the most commonly used methods to control diabetes. Oral medication has the risk of causing hypoglycemia, nausea, vomiting, diarrhea, weight loss, lactic acidosis, etc. Long-term injection medication can cause hypoglycemia, weight gain, subcutaneous fat hyperplasia and atrophy, and insulin allergy. Summary of the invention

[0008] The purpose of the present invention is to provide a compound preparation for external use in treating diabetes and a preparation method thereof, so as to solve the technical problems in the prior art that oral medicines produce serious side effects on the human body and have unstable therapeutic effects.

[0009] The technical solution adopted by the present invention to solve its technical problem is: A compound preparation for external use to treat diabetes, comprising an agent A and an agent B, wherein the agent A is used for meridian medication, and the agent B is used for acupoint medication.

[0010] The invention discloses an external compound preparation for treating diabetes. The agent A comprises the following raw materials and parts by weight: 10-12 parts of wormwood, 5-7 parts of safflower, 6-8 parts of prickly ash, 10-12 parts of millettia reticulata, 10-12 parts of lycopodiella ciliata, 10-12 parts of schizonepeta tenuifolia, 10-12 parts of schizonepeta spatholobi, 10-12 parts of borneol, 10-12 parts of Uncaria rhynchophylla, 10-12 parts of Gastrodia elata, 120-150 parts of gypsum, 70-80 parts of anemarrhena asphodeloides, 40-50 parts of roasted liquorice, 3-5 parts of rehmannia glutinosa, 3-5 parts of codonopsis pilosula, 3-5 parts of trichosanthes root, and 3-5 parts of coptis chinensis.

[0011] The invention discloses a compound preparation for external use to treat diabetes. The agent A comprises the following raw materials and parts by weight: 11 parts of mugwort, 6 parts of safflower, 7 parts of prickly ash, 11 parts of millettia reticulata, 11 parts of lycopodiella ciliata, 11 parts of schizonepeta tenuifolia, 11 parts of peony root, 11 parts of borneol, 11 parts of Uncaria rhynchophylla, 11 parts of Gastrodia elata, 140 parts of gypsum, 75 parts of Anemarrhena asphodeloides, 45 parts of roasted liquorice, 4 parts of rehmannia root, 4 parts of Codonopsis pilosula, 4 parts of Radix Trichosanthis, and 4 parts of Coptidis chinensis.

[0012] The invention discloses a compound preparation for external use in treating diabetes, wherein the agent B comprises the following raw materials and their weight proportions: 3-5 parts of Radix Trichosanthis, 1-3 parts of Rhizoma Coptidis, 1-2 parts of Radix Glycyrrhizae, 2-3 parts of Rhizoma Anemarrhenae, 3-5 parts of Radix Rehmanniae, 8-12 parts of lotus root juice, 8-12 parts of milk, 2-5 parts of Radix Ophiopogonis, 2-5 parts of Radix Scrophulariae; and 5-7 parts of Gypsum.

[0013] The invention discloses a compound preparation for external use in treating diabetes, wherein the agent B comprises the following raw materials and parts by weight: 4 parts of Radix Trichosanthis, 2 parts of Rhizoma Coptidis, 2 parts of Radix Glycyrrhizae, 3 parts of Rhizoma Anemarrhenae, 4 parts of Radix Rehmanniae, 10 parts of lotus root juice, 10 parts of milk, 3 parts of Radix Ophiopogonis, 4 parts of Radix Scrophulariae; and 6 parts of Gypsum.

[0014] The invention discloses an external compound preparation for treating diabetes, wherein the A agent and the B agent further comprise olive oil, oxtail, lotus root juice and white beeswax.

[0015] A method for preparing a compound preparation for external use to treat diabetes, comprising the following steps: S1. Weigh the raw materials of Agent A and Agent B respectively by weight; S2, putting the raw materials in step s1 into containers, adding olive oil, sealing and storing for a period of time; S3, boiling the stored olive oil mixture separately; S4, filtering the boiled mixed solution to form two intermediate solutions; S5, adding beef float, lotus root juice and white beeswax into the two intermediate liquids and heating them respectively until deepening to form two primary products; S6. After the initial product is cooled, it is packaged to form the final products of A and B.

[0016] In the method for preparing a compound preparation for external use in treating diabetes of the present invention, the weight of the olive oil in step s2 is at least twice the weight of the medicinal material.

[0017] The present invention provides a method for preparing a compound preparation for external use in treating diabetes. The storage time in s2 is 10-15 days in autumn and winter, and 7-10 days in spring and summer.

[0018] Efficacy and characteristics of each herbal medicine in Agent A: Mugwort: It has the effects of warming the meridians, removing dampness, dispelling cold, stopping bleeding, anti-inflammatory, relieving asthma, relieving cough, stabilizing pregnancy, and anti-allergic.

[0019] Safflower: pungent, warm, enters the heart and liver meridians, promotes blood circulation and dredges the menstruation, removes blood stasis and relieves pain, treats amenorrhea, abdominal masses, pain caused by blood stasis, carbuncles, and injuries from falls.

[0020] Zanthoxylum bungeanum: warms the middle and dispels cold, removes dampness, relieves pain, kills insects, and removes fishy odor. It is used to treat food stagnation, cold pain in the heart and abdomen, vomiting, belching, coughing and gas reversal, wind-cold-dampness arthralgia, diarrhea, dysentery, hernia pain, toothache, ascariasis, pinworm disease, vaginal itching, and scabies.

[0021] Millettia reticulata: bitter, sweet, warm, and has the effects of dispelling wind, activating blood circulation, and relaxing muscles and tendons. It is mainly used to treat sore waist and knees, numbness, paralysis, and irregular menstruation.

[0022] Stretching grass: bitter, slightly spicy, warm in nature, has the effect of dispelling wind and dampness, relaxing muscles and activating blood circulation, and is used for joint pain and difficulty in flexion and extension.

[0023] Radix Pseudostellariae: sweet, pungent, warm, enters the lung and liver meridians, has the effects of dispelling wind and dampness, relaxing the meridians and activating collaterals, promoting blood circulation and relieving pain, detoxifying and removing rashes Borneol: It has the effects of invigorating the mind, clearing away heat and relieving pain. It is often used for fever, coma, convulsions, stroke, phlegm, qi stagnation, coma, chest pain, red eyes, mouth sores, sore throat, and pus in the ear canal.

[0024] Uncaria rhynchophylla: It tastes sweet and is cool in nature. It has the functions of clearing away heat and calming the liver, extinguishing wind and stopping convulsions. It is mainly used to treat hypertension, dizziness, nervous headaches, etc.

[0025] Gastrodia elata: sweet, pungent, neutral, belongs to the liver meridian, can be used to extinguish wind and stop spasms, calm liver yang, dispel wind and dredge collaterals. Functions and indications: acute and chronic convulsions, convulsions and cramps, tetanus, vertigo, headache, hemiplegia, limb numbness, rheumatic pain Gypsum: Gypsum is cool in nature and has the effect of clearing away heat and detoxifying. Anemarrhena: bitter and cold; enters the lung, stomach and kidney meridians, has the effects of clearing away heat and purging fire, nourishing yin and moistening dryness, promoting body fluid and quenching thirst, and can be used for yin deficiency and thirst, with symptoms of thirst, frequent drinking and frequent urination.

[0026] Roasted Licorice: It nourishes yin and blood, replenishes qi and promotes yang, and restores pulse and calms palpitations. It is mainly used to treat deficiency of both yin and yang in the heart. Based on the clinical application of Zhang Zhongjing, later doctors expanded it to treat asthenia, pulmonary tuberculosis, and dryness of the lungs and yin damage. Modern doctors use it to treat cardiovascular diseases and other systemic diseases. Shengdi: It is cool in nature, sweet and bitter in taste, and has the effects of nourishing yin and tonifying the kidney, nourishing blood and cooling blood. It is used for yin damage caused by febrile disease, red tongue and thirst, spots and rashes, vomiting blood, epistaxis, and sore throat.

[0027] Codonopsis: sweet in taste, neutral in nature; enters the spleen and lung meridians; has the effects of strengthening the spleen and lungs, nourishing blood and promoting body fluid. Modern pharmacological studies have shown that Codonopsis also has a variety of pharmacological effects such as enhancing immunity, protecting gastrointestinal mucosa and resisting ulcers, promoting hematopoiesis, regulating blood sugar, and delaying aging; Radix Trichosanthis: It is a heat-clearing and fire-purging drug. Its specific effects are clearing away heat and fire, promoting body fluid and quenching thirst, draining pus and reducing swelling. It is mainly used to treat thirst due to fever, diabetes, jaundice, dry cough and hemoptysis, carbuncle, hemorrhoids and fistula. It is often used in combination with yin-nourishing drugs to treat both the symptoms and the root cause.

[0028] Coptis chinensis: bitter in taste, cold in nature, has the effects of clearing away heat and dampness, purging fire and detoxifying. It is used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, vomiting and bleeding due to blood heat, red eyes, toothache, thirst, carbuncle and furuncle; external treatment of eczema, wet sores, and pus in the ear canal.

[0029] The efficacy and characteristics of each medicinal material in Agent B are as follows: Radix Trichosanthis: It is a heat-clearing and fire-purging drug. Its specific effects are clearing away heat and fire, promoting body fluid and quenching thirst, draining pus and reducing swelling. It is mainly used to treat thirst due to fever, diabetes, jaundice, dry cough and hemoptysis, carbuncle, hemorrhoids and fistula. It is often used in combination with yin-nourishing drugs to treat both the symptoms and the root cause.

[0030] Coptis chinensis: bitter in taste, cold in nature, has the effects of clearing away heat and dampness, purging fire and detoxifying. It is used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and coma, hyperactivity of heart fire, restlessness and insomnia, vomiting and bleeding due to blood heat, red eyes, toothache, thirst, carbuncle and furuncle; external treatment of eczema, wet sores, and pus in the ear canal.

[0031] Roasted Licorice: It nourishes yin and blood, replenishes qi and promotes yang, and restores pulse and calms palpitations. It is mainly used to treat deficiency of both yin and yang in the heart. Based on the clinical application of Zhang Zhongjing, later doctors expanded it to treat asthenia, pulmonary tuberculosis, and dryness of the lungs and yin damage. Modern doctors use it to treat cardiovascular diseases and other systemic diseases. Anemarrhena: bitter and cold; enters the lung, stomach and kidney meridians, has the effects of clearing away heat and purging fire, nourishing yin and moistening dryness, promoting body fluid and quenching thirst, and can be used for yin deficiency and thirst, with symptoms of thirst, frequent drinking and frequent urination.

[0032] Raw Rehmannia: It is cool in nature, sweet and bitter in taste. It has the effects of nourishing yin and tonifying the kidney, nourishing blood and cooling blood. It is used for yin damage caused by febrile disease, red tongue, thirst, spots and rashes, vomiting blood, epistaxis, and sore throat.

[0033] Lotus root juice: It is cold in nature, sweet in taste, and enters the heart, spleen, and stomach meridians. It has the effects of stopping bleeding and cooling blood, moistening the intestines and promoting bowel movements, and replenishing blood and qi.

[0034] Ophiopogon: sweet, slightly bitter, slightly cold. It has the effects of moistening the lungs and clearing the heart, purging heat and promoting the production of body fluid, resolving phlegm and stopping vomiting, and treating cough and diuresis. Modern pharmacological research shows that Ophiopogon mainly contains scutellaria baicalensis glycosides, steroidal saponins, alkaloids, sitosterol, glucose, amino acids, vitamins, etc. It has the effects of resisting fatigue, scavenging free radicals, improving cellular immune function and lowering blood sugar. In addition, Ophiopogon can also promote the recovery of pancreatic islet cell function, increase liver glycogen, and lower blood sugar. It is a commonly used product in prescriptions for diabetics.

[0035] Scrophularia: slightly cold in nature, sweet, bitter and salty in taste. It has the effects of cooling blood, nourishing yin, purging fire and detoxifying. It is used for yin damage caused by febrile diseases, red tongue and thirst, fever and rashes, constipation caused by body fluid damage, bone steaming and cough, red eyes, sore throat, scrofula, diphtheria, carbuncle, sore and poisonous. The root of Scrophularia contains trace amounts of volatile oil, phytosterols, oleic acid, linolenic acid, stearic acid, sugars, L-asparagine and alkaloids. Pharmacological experiments have shown that it has antihypertensive, antibacterial, hypoglycemic and antipyretic effects.

[0036] Gypsum: Gypsum is cool in nature and has the effect of clearing away heat and detoxifying.

[0037] The beneficial effects of the present invention are: a compound preparation for external treatment of diabetes and its preparation method are proposed, which is prepared with authentic Chinese medicinal materials as raw materials, and is selected from abundant Chinese medicinal materials and tested for efficacy according to the basic principles of traditional Chinese medicine theory and therapeutic medication in my country. It is a Chinese medicine formula and preparation method for meridian medication that accelerates blood circulation and increases metabolism on the basis of massage and acupuncture to assist in lowering blood sugar; detoxification, blood circulation and blood stasis reduction to reduce complications of diabetes. Diabetes is manifested as three more and one less, namely, polydipsia, polyuria, polyphagia and weight loss. The cause of the disease lies in the joint action of genetic factors and environmental factors. The innovation of the present invention is that it can be used for any type of diabetes, and has a good effect of lowering blood sugar and repairing pancreatic islet function; at the same time, it has the effects of short course of treatment, quick effect, good efficacy and not easy to relapse; and the external use method has achieved small toxic and side effects, safe use, simple and reasonable configuration, wide source of medicine and convenient use. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention is clearly and completely described. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work belong to the scope of protection of the present invention.

[0039] Example: Agent A includes the following raw materials and parts by weight: 11 parts of mugwort, 6 parts of safflower, 7 parts of prickly ash, 11 parts of Millettia reticulata, 11 parts of Lycopodiella ciliata, 11 parts of Radix schizonepetae, 11 parts of Radix schizonepetae, 11 parts of borneol, 11 parts of Uncaria rhynchophyllae, 11 parts of Gastrodia elata, 140 parts of Gypsum gypsum, 75 parts of Anemarrhena asphodeloides, 45 parts of Radix Glycyrrhizae Preparata, 4 parts of Rehmannia glutinosa, 4 parts of Codonopsis pilosula, 4 parts of Radix Trichosanthis, and 4 parts of Coptis chinensis.

[0040] Among them, agent B includes the following raw materials and weight portions: 4 parts of Radix Trichosanthis, 2 parts of Rhizoma Coptidis, 2 parts of Radix Glycyrrhizae, 3 parts of Rhizoma Anemarrhenae, 4 parts of Radix Rehmanniae, 10 parts of lotus root juice, 10 parts of milk, 3 parts of Ophiopogon japonicus, 4 parts of Scrophularia ningpoensis; 6 parts of Gypsum.

[0041] The preparation method of agent A comprises the following steps: S1. Weigh and prepare wormwood, safflower, Zanthoxylum bungeanum, Millettia reticulata, Herba Lycopodii, Herba Scutellariae, Herba Scutellariae, Borneolum, Uncaria rhynchophyllae, Gastrodia elata, Gypsum gypsum, Rhizoma Anemarrhenae, Radix Glycyrrhizae Preparata, Radix Rehmanniae, Codonopsis pilosulae, Radix Trichosanthis and Rhizoma Coptidis according to weight; S2, putting the raw materials in step s1 into a container, adding olive oil, sealing and storing for a period of time; S3, boiling the stored olive oil mixture; S4, filtering the boiled mixed solution to form an intermediate solution; S5, adding beef float, lotus root juice and white beeswax to the intermediate liquid and heating it until it deepens to form a primary product; S6. After the initial product is cooled, it is packaged to form the final product.

[0042] In the method for preparing a compound preparation for external use in treating diabetes of the present invention, the weight of the olive oil in step s2 is at least twice the weight of the medicinal material.

[0043] The present invention provides a method for preparing a compound preparation for external use to treat diabetes. The storage time in s2 is 10-15 days in autumn and winter, and 7-10 days in spring and summer.

[0044] The components of Agent B include the following raw materials and their weight proportions: 4 parts of Radix Trichosanthis, 2 parts of Rhizoma Coptidis, 2 parts of Radix Glycyrrhizae, 3 parts of Rhizoma Anemarrhenae, 4 parts of Radix Rehmanniae, 10 parts of Lotus Root Juice, 10 parts of Milk, 3 parts of Radix Ophiopogonis, 4 parts of Scrophulariae; and 6 parts of Gypsum.

[0045] The preparation method of agent B comprises the following steps: S1, Radix Trichosanthis, Rhizoma Coptidis, Radix Glycyrrhizae, Rhizoma Anemarrhenae, Radix Rehmanniae, Lotus Root Juice, Milk, Radix Ophiopogonis, Radix Scrophulariae and Gypsum are weighed and prepared according to weight; S2, putting the raw materials in step s1 into a container, adding olive oil, sealing and storing for a period of time; S3, boiling the stored olive oil mixture; S4, filtering the boiled mixed solution to form an intermediate solution; S5, adding beef float, lotus root juice and white beeswax to the intermediate liquid and heating it until it deepens to form a primary product; S6. After the initial product is cooled, it is packaged to form the final product.

[0046] As a preferred embodiment, the weight of the olive oil in step s2 is at least twice the weight of the medicinal material.

[0047] As a preferred embodiment, the storage time in s2 is 10-15 days in autumn and winter, and 7-10 days in spring and summer. The Chinese medicine formula dispensing principle and treatment idea of ​​the present invention The Chinese traditional medicine of diabetes first appeared in Huangdi Neijing·Qibinglun, named diabetes. According to Chinese medicine, diabetes is characterized by lung heat damaging body fluid and thirst and drinking a lot of water; stomach fire burning and digestion and hunger are middle-level diabetes; kidney failure to absorb water and frequent urination are lower-level diabetes. Lung dryness, stomach heat, and kidney deficiency occur together, or with one of them being more prominent, resulting in diabetes. Without one of them, it cannot be a disease. Modern medicine believes that diabetes is a chronic disease marked by high blood sugar caused by absolute or relative insufficient secretion and utilization of insulin. The disease is mainly divided into three types: type 1, type 2, and gestational diabetes. The cause is mainly attributed to the combined effects of genetic and environmental factors, including pancreatic cell dysfunction leading to decreased insulin secretion, or the body's insensitivity to insulin, or both, which prevents glucose in the blood from being effectively utilized and stored. The present invention determines a treatment method that mainly removes toxins, removes evil spirits, activates blood circulation and removes stasis, accelerates metabolism, lowers blood sugar, and prevents complications. The formula combines Sun's self-developed Chinese acupuncture and Chinese acupoint medication, and acupoint manipulation to accelerate blood circulation in all directions, enhance the body's metabolism, and thus lower blood sugar; removes toxins, removes evil spirits, activates blood circulation and removes stasis, improves the common blood stasis symptoms of diabetic patients, and prevents the occurrence of complications. Based on the traditional Chinese medicine syndrome differentiation and treatment, the present invention combines many years of clinical observation and research findings, and finds that this prescription has a good effect on lowering blood sugar and activating blood circulation and removing stasis in diabetes. Modern medical pharmacology studies show that this prescription has a good effect on detoxification, dredging meridians, and preventing complications.

[0048] Pharmacological principle of agent A: Radix Trichosanthis is bitter and slightly cold, and it enters the lung and stomach meridians. It is often used in combination with yin-nourishing drugs to treat diabetes in order to achieve the effect of treating both the symptoms and the root cause; Codonopsis pilosula: sweet, neutral in nature; enters the spleen and lung meridians; has multiple pharmacological effects such as hematopoiesis, regulating blood sugar, and delaying aging; Anemarrhena asphodeloides: bitter and cold in taste; enters the lung, stomach, and kidney meridians, and has the effects of clearing away heat and purging fire, nourishing yin and moistening dryness, and promoting body fluid and quenching thirst, and can be used for yin deficiency and thirst, with symptoms of thirst, frequent drinking, and frequent urination; Radix Rehmanniae: cool in nature, sweet and bitter in taste, and can be used for heat disease that damages yin, red tongue, and thirst, and the four are collectively the main drugs; Millettia reticulata, Herba Lycopodii, Herba Polygoni Multiflori, and Rhizoma Uncariae have the effects of relaxing meridians and activating collaterals, dispelling wind and dampness, and activating blood circulation and relieving pain, and are collectively the minister drugs; Rhizoma Coptidis, Herba Artemisiae Argyi, Safflower, Zanthoxylum bungeanum, Borneol, Gastrodia elata, Gypsum Fibrosum, and Radix Glycyrrhizae Radix have the effects of purging fire and detoxifying, activating blood circulation and tendons, and clearing heat and relieving pain, and are collectively the guiding drugs.

[0049] How to use Agent A: Take an appropriate amount of this product for massage of the two golden lines in traditional Chinese medicine, three times a day for treatment. Use it every day during the treatment phase and once every 3 days during the consolidation phase.

[0050] Pharmacological principle of Agent B: Radix Trichosanthis is bitter and slightly cold, and it belongs to the lung and stomach meridians. It is often used in combination with yin-nourishing drugs to treat diabetes in order to achieve the effect of treating both the symptoms and the root causes; Radix Ophiopogonis: It is sweet, slightly bitter, and slightly cold, and it has the effect of promoting the recovery of pancreatic islet cell function, increasing liver glycogen, and lowering blood sugar. Radix Scrophulariae: It is slightly cold in nature, and tastes sweet, bitter, and salty; it has antihypertensive, antibacterial, hypoglycemic and antipyretic effects, and is the main drug. Rhizoma Coptidis, Rhizoma Anemarrhenae, and Radix Glycyrrhizae have the effects of clearing heat and drying dampness, purging fire and detoxifying, and promoting fluid and quenching thirst, and are the assistant drugs. Radix Rehmanniae is often used for febrile diseases that damage yin, red tongue and polydipsia, and gypsum has the effect of clearing heat and detoxifying, and the two are the guiding drugs; Rhizoma Anemarrhenae, Radix Rehmanniae, lotus root juice, and milk have the effects of nourishing blood, promoting fluid and moistening dryness, and are the guiding drugs.

[0051] How to use Agent B: Take an appropriate amount of this product during Chinese medicine massage and apply it to the Shenque acupoint. Massage gently until absorbed. Use once in the morning and evening. It needs to be used throughout the treatment cycle. The Chinese medicine formula applied for this time comes from the founder Sun Xianguo's family. Sun's Meridian Sugar-Removing Paste is mainly used for detoxification, regulating blood sugar, and promoting blood circulation and removing blood stasis. The main formulas include: mugwort, safflower, pepper, Millettia reticulata, spatholobi, radix spatholobi, borneol, Uncaria rhynchophylla, Gastrodia elata, gypsum, Rhizoma Anemarrhenae, licorice, Radix Rehmanniae, Codonopsis pilosulae, Radix Trichosanthis, and Rhizoma Coptidis. In traditional Chinese medicine theory, diabetes is often related to dysfunction of the lungs, stomach, kidneys and other internal organs. Sun's acupoint hypoglycemic paste can repair the internal organs and lower blood sugar. Meridian Sugar-Removing Paste can promote blood circulation and remove blood stasis, detoxify, improve the common blood stasis symptoms of diabetic patients, and prevent the occurrence of complications. Since 2008, Sun has officially started to treat diabetic patients with serious complications, using traditional Chinese medicine secret recipes to treat diabetes. After two months of treatment, blood sugar gradually decreased, but the effect did not meet expectations. Sun added other Chinese medicine treatment methods such as acupuncture and massage, turning the single hypoglycemic prescription into a comprehensive Chinese medicine treatment plan. After the plan was improved, Sun successively treated 79 cases. Through Chinese medicine massage plus meridian sugar paste and acupuncture, acupoint medication comprehensive treatment, after 15 days of treatment, the blood sugar of 79 diabetic patients began to decrease. After one month of treatment, patients who took medicine and injected insulin began to reduce the dosage. After three months of treatment, the blood sugar of patients who took medicine completely reduced the medicine, and the blood sugar of fasting blood sugar was still stable, reaching below 7.0mmol / l, and the blood sugar was basically controlled within 8mmol / l 2 hours after the meal. The treatment time of patients who took insulin was different according to the insulin unit. Usually, after 4-10 months of treatment, the blood sugar of insulin was also stable, with fasting blood sugar below 7.0mmol / l and postprandial blood sugar within 8mmol / l. After stopping medication and injections, the consolidation treatment lasted for one month and the blood sugar level reached clinical cure. After half a year, the blood sugar level was basically normal.

[0052] Clinical Cases: The beneficial effects of the drug of the present invention are further illustrated by clinical experiments. These experiments are conducted using the Chinese medicine formula for external use in treating diabetes and lowering blood sugar in the above-mentioned embodiment of the present invention in combination with traditional Chinese medicine massage manipulation, acupoint pressing and acupuncture comprehensive treatment plan.

[0053] Clinical medication practice research and statistics Source of cases: Looking back at the diabetic patients that Sun has treated since 2008, a total of 79 diabetic patients have been treated. Excluding 19 patients who did not complete all the treatment due to personal reasons during the treatment period, a total of 60 patients completed clinical observation, including 45 patients with complications, 29 male patients and 41 female patients.

[0054] Treatment (1) The A and B agents prepared according to the formula and process of the embodiment of the present invention are used in the following manner: take an appropriate amount of the A agent and massage it on the golden two lines until it is absorbed; and take an appropriate amount of the B agent and massage it on the Shenque acupoint until it is absorbed, and at the same time cooperate with TCM acupoint medication, TCM acupoint pressing, and acupuncture comprehensive treatment. (2) Provide basic diabetes education (3) Develop a diet and exercise plan (4) Conduct blood glucose monitoring and management The treatment period for patients is 3-6 months Efficacy standard (unit: mmol / l): Blood sugar standard after stopping injection and medication: complete reversal, i.e. fasting blood sugar within 3.3-6.1mmol / l, blood sugar within 3.9-7.8mmol / l 2 hours after meal, and glycosylated hemoglobin within 6%; ideal treatment state: fasting blood sugar within 4.4-6.1mmol / l, blood sugar 4.4-8.0mmol / l 2 hours after meal, glycosylated hemoglobin 4%-6%; effective treatment and good state: fasting blood sugar 6.1-7.0mmol / l, blood sugar 8.0-10.0mmol / l two hours after meal, glycosylated hemoglobin 6.5%-7.5%; very poor treatment effect: fasting blood sugar greater than 7.0mmol / l, blood sugar greater than 10.0mmol / l 2 hours after meal, and glycosylated hemoglobin greater than 7.5%.

[0055] According to the blood sugar monitoring data after treatment, the patients were divided into 4 levels: cured, i.e. fasting blood sugar within 3.3-6.1mmol / l, blood sugar within 3.9-7.8mmol / l 2 hours after meal, and glycosylated hemoglobin within 6%. Effective treatment, i.e. fasting blood sugar within 4.4-6.1mmol / l, blood sugar 4.4-8.0mmol / l 2 hours after meal, and glycosylated hemoglobin 4%-6%. Effective treatment: fasting blood sugar 6.1-7.0mmol / l, blood sugar 8.0-10.0mmol / l 2 hours after meal, and glycosylated hemoglobin 6.5%-7.5%. Ineffective treatment: fasting blood sugar greater than 7.0mmol / l, blood sugar greater than 10.0mmol / l 2 hours after meal, and glycosylated hemoglobin greater than 7.5%. After 3-6 months of treatment with Sun's TCM comprehensive treatment plan for sugar inversion, no obvious adverse reactions were observed, with 5 cases cured, 37 cases effective, 18 cases effective, and 0 cases ineffective. The overall effective rate is 100%.

[0056] The medicine of the formula of the present invention has mild medicinal properties and has the effects of lowering blood sugar, repairing pancreatic islet function, and regulating the internal organs. After a long period of clinical observation, the formula of the present invention has significant therapeutic effect, high safety, simple use method, no obvious adverse reactions, and is easily accepted by patients and their families.

[0057] Case examples: Jiang, female, 57 years old, came to the clinic on May 1, 2024 for gastric bleeding caused by complications of diabetes. She was pale and weak all over when she came to the clinic. She was hospitalized 6 times for gastric bleeding in 3 months. Her overall physical condition was very poor. She took 40 units of insulin every day when she came to the clinic. Her fasting blood sugar still reached 9.6mmol / l, and her blood sugar was as high as 20mmol / l 2 hours after a meal. Western medicine diagnosed her with type 2 diabetes with poor blood sugar control, gastrointestinal bleeding, hypertension, acute hemorrhagic anemia, hyperlipidemia and splenomegaly. On May 1, 2024, Sun began to treat her with the prescription of the present invention combined with comprehensive treatment plans such as Chinese medicine meridian massage, acupoints, i.e. acupuncture, etc. During the treatment period, she cooperated with diet control and exercise therapy. After half a month of treatment, she began to reduce the insulin unit, reducing 2 units of insulin every 3 days. The treatment time was until July 29, 2024, when the insulin was completely reduced. On August 3, 2024, the glycated hemoglobin was 6.4%, the fasting blood sugar was between 7.2-7.4mmol / l, and the blood sugar 2 hours after meal was less than 7.8mmol / l, achieving a good treatment effect. Sun diagnosed that Jiang needed 6 months of treatment to achieve a cure. Currently, the treatment cycle has just passed halfway, and the treatment effect is significant.

[0058] Xiao, female, 67 years old, came to the clinic on April 2, 2024 due to painful diabetic foot. The western doctor judged that if the pain persisted and could not be relieved, amputation was required. She could not walk normally when she came to the clinic. She came to the clinic by car. She was weak all over, in poor spirits, and had walking difficulties. She took 12 units of insulin every day. Her fasting blood sugar was 26mmol / l. Her blood sugar exceeded the standard 2 hours after a meal and could not be measured by the blood glucose meter. She started diabetic foot on April 2, 2024. On April 3, she was treated with the drug of the present invention combined with Sun's acupuncture, massage and acupoint comprehensive program to treat diabetes. After three days of treatment, fasting blood sugar dropped to 15mmol / l, and postprandial blood sugar dropped to 20mmol / l. After three days of treatment, walking disorder was relieved. After one week of treatment, he could walk normally. After half a month of treatment, he began to reduce 2 units of insulin every 3 days. After one and a half months, insulin was completely removed. Fasting blood sugar dropped to 8.5mmol / l, and blood sugar 2 hours after meal was 9mmol / l. He was discharged from the hospital after 2 months of treatment. Fasting blood sugar reached 4.2-7.0mmol / l, and blood sugar 2 hours after meal was 4.4-8.0mmol / l.

[0059] Liu, female, 68 years old, came to the clinic on January 15, 2024 due to frequent urination and poor sleep. Western medicine judged: type 2 diabetes with poor blood sugar control, long-term use of metformin, fasting blood sugar as high as 16.8mmol / l during medication, on January 15, 2024, the drug of the present invention combined with Sun's acupuncture, massage and acupoint comprehensive treatment plan was used for treatment. After 3 days of treatment, urine began to decrease, and the drug was reduced after half a month of treatment. After one and a half months of treatment, the drug was completely removed, and the fasting blood sugar was controlled at 6.8mmol / l, and the blood sugar two hours after meals was 8.0mmol / l. She was discharged from the hospital after 3 months of treatment. At the time of discharge, the fasting blood sugar was controlled within 6.1mmol / l, and the blood sugar two hours after meals was controlled within 7.8mmol / l.

[0060] It should be understood that those skilled in the art can make improvements or changes based on the above description, and all these improvements and changes should fall within the scope of protection of the appended claims of the present invention.

Claims

1. A compound preparation for external use in treating diabetes, characterized in that: It comprises an A agent and a B agent, wherein the A agent is used for meridian medication, and the B agent is used for acupoint medication.

2. A compound preparation for external use for treating diabetes according to claim 1, characterized in that: The A agent includes the following raw materials and their weight portions: 10-12 parts of mugwort, 5-7 parts of safflower, 6-8 parts of prickly ash, 10-12 parts of Millettia reticulata, 10-12 parts of Lycopodiella ciliata, 10-12 parts of Radix schizonepetae, 10-12 parts of Herba spatholobi, 10-12 parts of borneol, 10-12 parts of Uncaria rhynchophyllae, 10-12 parts of Gastrodia elata, 120-150 parts of Gypsum gypsum, 70-80 parts of Rhizoma Anemarrhenae, 40-50 parts of Radix Glycyrrhizae Preparata, 3-5 parts of Radix Rehmanniae, 3-5 parts of Codonopsis pilosulae, 3-5 parts of Radix Trichosanthis, and 3-5 parts of Rhizoma Coptidis.

3. A compound preparation for external use for treating diabetes according to claim 2, characterized in that: The A agent includes the following raw materials and their weight parts: 11 parts of mugwort, 6 parts of safflower, 7 parts of prickly ash, 11 parts of Millettia reticulata, 11 parts of Lycopodiella ciliata, 11 parts of Radix schizonepetae, 11 parts of Radix spatholobi, 11 parts of borneol, 11 parts of Uncaria rhynchophyllae, 11 parts of Gastrodia elata, 140 parts of Gypsum gypsum, 75 parts of Anemarrhena asphodeloides, 45 parts of Radix Glycyrrhizae Preparata, 4 parts of Rehmannia glutinosa, 4 parts of Codonopsis pilosula, 4 parts of Radix Trichosanthis, and 4 parts of Coptis chinensis.

4. The compound preparation for external use for treating diabetes according to claim 1, characterized in that: The agent B comprises the following raw materials and their weight proportions: 3-5 parts of Radix Trichosanthis, 1-3 parts of Rhizoma Coptidis, 1-2 parts of Radix Glycyrrhizae, 2-3 parts of Rhizoma Anemarrhenae, 3-5 parts of Radix Rehmanniae, 8-12 parts of lotus root juice, 8-12 parts of milk, 2-5 parts of Radix Ophiopogonis, 2-5 parts of Radix Scrophulariae; and 5-7 parts of Gypsum.

5. The compound preparation for external use for treating diabetes according to claim 4, characterized in that: The agent B comprises the following raw materials and their weight proportions: 4 parts of Radix Trichosanthis, 2 parts of Rhizoma Coptidis, 2 parts of Radix Glycyrrhizae, 3 parts of Rhizoma Anemarrhenae, 4 parts of Radix Rehmanniae, 10 parts of lotus root juice, 10 parts of milk, 3 parts of Radix Ophiopogonis, 4 parts of Radix Scrophulariae; and 6 parts of Gypsum.

6. The compound preparation for external use for treating diabetes according to claim 5, characterized in that: The A and B agents also include olive oil, beef float, lotus root juice and white beeswax.

7. The method for preparing a compound preparation for external use for treating diabetes according to claim 6, characterized in that: The following steps are involved: S1. Weigh the raw materials of Agent A and Agent B respectively by weight; S2, putting the raw materials in step s1 into containers, adding olive oil, sealing and storing for a period of time; S3, boiling the stored olive oil mixture separately; S4, filtering the boiled mixed solution to form two intermediate solutions; S5, adding beef float, lotus root juice and white beeswax into the two intermediate liquids and heating them respectively until deepening to form two primary products; S6. After the initial product is cooled, it is packaged to form the final products of A and B.

8. The method for preparing a compound preparation for external use for treating diabetes according to claim 7, characterized in that: The weight of the olive oil in step s2 is at least twice the weight of the medicinal material.

9. The method for preparing a compound preparation for external use for treating diabetes according to claim 7, characterized in that: The storage time in s2 is 10-15 days in autumn and winter, and 7-10 days in spring and summer.