A traditional Chinese medicine compound preparation for treating androgenic alopecia and a preparation method thereof

Abstract

The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine compound preparation for treating androgenic alopecia and a preparation method thereof.The raw materials of the traditional Chinese medicine compound preparation are composed of salvia miltiorrhiza, astragalus, coix seed, sophora flavescens, torrefied atractylodes, angelica, licorice, salted cortex phellodendri, chuanqiong and chuanxiong.The preparation method is as follows: the raw materials are mixed, then soaked in water, boiled by large fire, changed to small fire, continuously boiled by small fire, filtered to obtain medicinal liquid and residue;the residue is continuously boiled by large fire until boiling, then changed to small fire, continuously boiled by small fire, filtered again to obtain secondary medicinal liquid;the medicinal liquid obtained twice is combined, concentrated and refrigerated for standby.The traditional Chinese medicine compound preparation has good therapeutic effect on androgenic alopecia through pharmacodynamic test, and has good market promotion value and potential.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, and in particular to a traditional Chinese medicine compound preparation for treating androgenetic alopecia and its preparation method. Background Technology

[0002] Androgenetic alopecia (AGA) is the most common type of hair loss in clinical practice. Male androgenetic alopecia typically begins around puberty and is characterized by a progressive receding hairline, which may be accompanied by thinning and thinning of hair on the crown. In severe cases, it can lead to baldness. Common symptoms include seborrhea, itching, increased scaling, and folliculitis, which can significantly negatively impact a patient's personal image, mental health, and quality of life.

[0003] Male pattern baldness (AGA) is characterized by genetic correlation, androgen dependence, and multi-pathway regulation. Currently, clinical treatments for AGA mainly include medication, local scalp injections, laser therapy, and hair transplantation. While these treatments have some effectiveness, they are also characterized by drug side effects and high relapse rates after discontinuation. Oral finasteride and topical minoxidil are currently the first-line treatments for AGA, with reliable efficacy. Finasteride is a type II 5α-reductase inhibitor that inhibits the conversion of testosterone to dihydrotestosterone, thus having an anti-androgenic effect. However, due to its potential side effects such as erectile dysfunction, some patients cannot tolerate long-term use. The mechanism of action of minoxidil in treating AGA may be related to its vasodilatory effect and improved local scalp blood perfusion. Its main adverse reactions include scalp itching, scaling, and hirsutism. In addition, scalp injections of platelet-rich plasma, botulinum toxin injections, and low-energy laser therapy have also achieved some efficacy, but their high cost limits their widespread clinical application.

[0004] Therefore, androgenetic alopecia has become a research hotspot for disfiguring skin diseases, and it is urgent to explore safe and effective treatment drugs and methods. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine compound preparation for treating androgenetic alopecia and its preparation method.

[0006] Specifically, this application provides the following technical solutions:

[0007] A traditional Chinese medicine compound preparation for treating androgenetic alopecia, the raw materials of which are composed of Danshen, Huangqi, Yiyiren, Kushen, stir-fried Cangzhu, Danggui, Gancao, salt-processed Huangbai, Niuxi, and Chuanxiong.

[0008] Furthermore, the dosage of each component of the raw material is as follows: 5 parts of Salvia miltiorrhiza, 6 parts of Astragalus membranaceus, 4 parts of Coix lacryma-jobi, 3 parts of Sophora flavescens, 3 parts of stir-fried Atractylodes lancea, 2 parts of Angelica sinensis, 2 parts of Glycyrrhiza uralensis, 3 parts of salt-processed Phellodendron chinense, 3 parts of Achyranthes bidentata, and 2 parts of Ligusticum chuanxiong.

[0009] This invention also provides a method for preparing a traditional Chinese medicine compound for treating androgenetic alopecia, specifically as follows: after mixing the raw materials, soak them in water for 20-40 minutes, bring to a boil over high heat, then reduce to low heat and continue simmering for 40-60 minutes, filter to obtain the decoction and dregs; continue to boil the dregs over high heat until boiling, then reduce to low heat and continue simmering for 20-40 minutes, filter again to obtain a secondary decoction; combine the two decoctions and concentrate them.

[0010] The concentration of the concentrated crude drug was 1.65 g / mL.

[0011] In addition to concentrated decoctions, raw materials can be pre-processed and extracted, and then excipients can be added to produce oral liquids, granules, tablets, capsules, or honey pills.

[0012] The oral liquid preparation method is as follows: boil the raw material in boiling water for 10 minutes, remove it, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract to a relative density of 1.05±0.02, centrifuge at high speed to remove impurities and purify, cool and let stand for 24 hours, take the supernatant, filter the pulp cake, concentrate to a relative density of 1.15~1.20, dispense, sterilize, and the oral liquid is obtained.

[0013] The preparation method of the capsule is as follows: boil the raw drug in boiling water for 10 minutes, take it out, let it soak thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, pulverize it into fine powder, add ethanol to granulate, dry it, and fill it into capsules to obtain the capsule.

[0014] The preparation method of granules is as follows: boil the raw drug in boiling water for 10 minutes, remove it, let it soak thoroughly, add 10 times the amount of 50% ethanol (volume fraction), heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure and vacuum dry the extract to a relative density of 1.05±0.02, centrifuge at high speed to remove impurities and purify, cool and let stand for 24 hours, take the supernatant, filter the pulp cake, concentrate to a relative density of 1.15~1.20, spray dry, dry granulate, and package with aluminum-plastic composite film to obtain granules.

[0015] The tablet preparation method is as follows: boil the raw drug in boiling water for 10 minutes, remove it, let it soak thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, pulverize it into fine powder, add starch, granulate, and compress to obtain tablets.

[0016] The method for preparing honey pills is as follows: Boil the raw drug in boiling water for 10 minutes, remove it, let it soak thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, pulverize it into fine powder, add refined honey, and stir the honey and drug powder in a mass ratio of 1.5:1 to prepare honey pills.

[0017] Compared with the prior art, the traditional Chinese medicine compound preparation for treating androgenetic alopecia and its preparation method of the present invention have at least the following beneficial effects:

[0018] This invention relates to a traditional Chinese medicine compound preparation composed of Danshen (Salvia miltiorrhiza), Huangqi (Astragalus membranaceus), Yiyiren (Coix lacryma-jobi), Kushen (Sophora flavescens), stir-fried Cangzhu (Atractylodes lancea), Danggui (Angelica sinensis), Gancao (Glycyrrhiza uralensis), salt-processed Huangbai (Phellodendron chinense), Niuxiong (Achyranthes bidentata), and Chuanxiong (Ligusticum chuanxiong). Kushen clears heat and dries dampness, Yiyiren promotes diuresis and eliminates dampness, and Cangzhu dries dampness and relieves numbness; all three herbs can eliminate dampness and are the principal herbs. Danshen cools the blood and invigorates blood circulation, Huangqi tonifies qi and replenishes deficiency, and Danggui tonifies blood and invigorates blood circulation; these four herbs promote qi and invigorate blood circulation, while Chuanxiong regulates qi and invigorates blood circulation, nourishes hair follicles, and promotes hair growth; these are the assistant herbs. Salt-processed Huangbai nourishes yin and reduces fire, and Niuxiong tonifies the liver and kidneys and guides the medicine downwards to eliminate dampness; these are the adjuvant herbs. Gancao harmonizes all the herbs and is the guiding herb. The entire formula, when combined, clears heat and eliminates dampness, invigorates qi and invigorates blood circulation, inhibits sebum production and promotes hair growth; therefore, it is particularly effective in treating androgenetic alopecia caused by internal damp-heat.

[0019] Studies have shown that the traditional Chinese medicine compound preparation of this invention has significant clinical and animal experimental effects in treating androgenetic alopecia models. This traditional Chinese medicine compound preparation improves androgenetic alopecia by clearing heat and dampness, invigorating qi and promoting blood circulation, inhibiting sebum production and promoting hair growth, improving seborrheic dermatitis of the scalp, and regulating androgen metabolism.

[0020] The following description, in conjunction with the accompanying drawings, further illustrates the traditional Chinese medicine compound preparation for treating androgenetic alopecia of the present invention and its preparation method. Attached Figure Description

[0021] Figure 1 These are clinical photos of the experimental group before and after treatment.

[0022] Figure 2 These are trichoscopic photographs of the experimental group before and after treatment (top left and top right are before treatment, bottom left and bottom right are after treatment). It can be seen that the hair density and scalp erythema improved after treatment. Detailed Implementation

[0023] Example 1: Preparation of Water Decoction

[0024] Take 15g of Salvia miltiorrhiza, 18g of Astragalus membranaceus, 12g of Coix lacryma-jobi, 9g of Sophora flavescens, 9g of Atractylodes lancea (stir-fried with wheat bran), 6g of Angelica sinensis, 6g of Glycyrrhiza uralensis, 9g of Phellodendron chinense (processed with salt), 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong. Mix them together and soak them in water for 20-40 minutes. Bring to a boil over high heat, then reduce to low heat and simmer for 40-60 minutes. Filter to obtain the decoction and dregs. Continue to boil the dregs over high heat until boiling, then reduce to low heat and simmer for 20-40 minutes. Filter again to obtain a second decoction. Combine the two decoctions and concentrate them. The concentration of the crude drug after concentration is 1.65g / mL.

[0025] Example 2: Preparation of Oral Liquid

[0026] Take 15g of Salvia miltiorrhiza, 18g of Astragalus membranaceus, 12g of Coix lacryma-jobi, 9g of Sophora flavescens, 9g of Atractylodes lancea (stir-fried with wheat bran), 6g of Angelica sinensis, 6g of Glycyrrhiza uralensis, 9g of Phellodendron chinense (processed with salt), 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong. Boil in boiling water for 10 minutes, remove, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (conditions: temperature 70℃, pressure 0.08MPa) to a relative density of 1.05±0.02 (temperature 60℃), centrifuge at high speed to remove impurities and purify, cool and stand for 24 hours, take the supernatant, filter the pulp cake, concentrate to a relative density of 1.15~1.20 (temperature 60℃), dispense, sterilize, and obtain the final product.

[0027] Example 3: Capsule Preparation

[0028] Take 15g of Salvia miltiorrhiza, 18g of Astragalus membranaceus, 12g of Coix lacryma-jobi, 9g of Sophora flavescens, 9g of Atractylodes lancea (stir-fried with wheat bran), 6g of Angelica sinensis, 6g of Glycyrrhiza uralensis, 9g of Phellodendron chinense (processed with salt), 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong. Boil in boiling water for 10 minutes, remove, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature 60℃, pressure 0.08MPa), pulverize into fine powder, granulate with ethanol, dry, and fill into capsules to obtain the final product.

[0029] Example 4: Granule Preparation

[0030] Take 15g of Salvia miltiorrhiza, 18g of Astragalus membranaceus, 12g of Coix lacryma-jobi, 9g of Sophora flavescens, 9g of Atractylodes lancea (stir-fried with wheat bran), 6g of Angelica sinensis, 6g of Glycyrrhiza uralensis, 9g of Phellodendron chinense (processed with salt), 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong. Boil in boiling water for 10 minutes, remove, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature 70℃, pressure 0.08MPa) to a relative density of 1.05±0.02 (temperature 60℃), centrifuge at high speed to remove impurities and purify, cool and stand for 24 hours, take the supernatant, filter the pulp cake, concentrate to a relative density of 1.15~1.20 (temperature 60℃), spray dry, dry granulate, and package in aluminum-plastic composite film to obtain the final product.

[0031] Example 5: Tablet Preparation

[0032] Take 15g of Salvia miltiorrhiza, 18g of Astragalus membranaceus, 12g of Coix lacryma-jobi, 9g of Sophora flavescens, 9g of Atractylodes lancea (stir-fried with wheat bran), 6g of Angelica sinensis, 6g of Glycyrrhiza uralensis, 9g of Phellodendron chinense (processed with salt), 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong. Boil them in boiling water for 10 minutes, remove them, let them soak thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature 60℃, pressure 0.08MPa), pulverize it into fine powder, add starch, granulate, and compress into tablets to obtain tablets.

[0033] Example 6: Preparation of Honey Pills

[0034] Take 15g of Salvia miltiorrhiza, 18g of Astragalus membranaceus, 12g of Coix lacryma-jobi, 9g of Sophora flavescens, 9g of Atractylodes lancea (stir-fried with wheat bran), 6g of Angelica sinensis, 6g of Glycyrrhiza uralensis, 9g of Phellodendron chinense (processed with salt), 9g of Achyranthes bidentata, and 6g of Ligusticum chuanxiong. Boil in boiling water for 10 minutes, remove, let it steep thoroughly, add 10 times the amount of 50% ethanol, and heat under reflux to extract three times, 1 hour each time. Combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract (temperature 60℃, pressure 0.08MPa), pulverize into a fine powder, add refined honey, and mix the honey and medicinal powder in a 1.5:1 ratio to prepare honey pills.

[0035] To verify the activity of the above-mentioned traditional Chinese medicine compound preparation, the decoction-form traditional Chinese medicine compound composition prepared in Example 1 was applied to male patients with androgenetic alopecia.

[0036] The diagnostic criteria for male androgenetic alopecia are based on the "2023 Chinese Clinical Practice Guidelines: Diagnosis and Treatment of Androgenetic Alopecia" (Chinese Society of Plastic Surgery, Working Group for the Development of Guidelines for the Diagnosis and Treatment of Androgenetic Alopecia, National Medical Quality Control Center for Plastic and Aesthetic Surgery, Chinese Association of Plastic and Aesthetic Surgery, et al. 2023 Chinese Clinical Practice Guidelines: Diagnosis and Treatment of Androgenetic Alopecia [J]. Chinese Journal of Plastic Surgery, 2024, 40(1):1-20.). The clinical manifestations are a receding hairline on the forehead and / or progressive thinning of hair on the top of the head, eventually revealing the scalp. It is usually accompanied by symptoms of increased sebum secretion on the scalp. Dermoscopy shows that the hair diameter variation rate in the bald area is >20%.

[0037] Case selection: (1) Inclusion criteria: Male, aged 20-45 years; diagnosed with AGA; Hamilton-Norwood classification meeting Vertex III, IV, or V; TCM diagnosis meeting damp-heat syndrome: at least two of the following symptoms were present: seborrheic dermatitis, erythema, pruritus, increased scaling, and folliculitis; accompanied by systemic symptoms such as sticky stools, poor appetite, abdominal distension, and heaviness in the limbs; able to adhere to medication and follow-up and sign informed consent form; no AGA-related treatment within 3 months. (2) Exclusion criteria: Comorbid hair diseases; allergy to the investigational drugs (minoxidil, finasteride, dehumidification therapy, control) and their components; concurrent liver and kidney dysfunction, malignant tumors, or mental disorders; participation in other clinical studies within the last 3 months; any other situation deemed unsuitable for participation by the investigator. Liver and kidney dysfunction. (3) Dropout criteria: poor adherence, such as failure to take medication regularly in sufficient doses or failure to attend follow-up appointments for more than 2 weeks; use of other AGA therapies during the intervention period; occurrence of serious adverse reactions during the intervention period; withdrawal from the study; or the researcher's opinion that the participant is not suitable to continue participating in the study.

[0038] Intervention regimens: (1) Control group: Finasteride tablets (specification: 1mg; manufactured by Merk Sharp & Dohme Limited; batch number: National Drug Approval Number J20150142) 1mg, orally once a day; Minoxidil tincture (specification: 5%; manufactured by Zhejiang Wansheng Pharmaceutical Co., Ltd.; batch number: National Drug Approval Number H20010714) appropriate amount, applied topically to the hair loss area twice a day. Treatment period: 6 months. (2) Experimental group: Drug in Example 1 30mL, orally twice a day; finasteride tablets and minoxidil tincture specifications and usage are the same as the control group. Treatment period: 6 months.

[0039] Baseline characteristics: Sixty-four patients meeting the above criteria were recruited and randomly assigned to a control group and a treatment group (n=32 each) using a block randomization table. The control group consisted of patients aged 23–45 years (mean age 33.19 ± 6.06 years), with a duration of androgenetic alopecia of 2–22 years (mean duration 8.75 ± 6.47 years), and classified as Norwood-Hamilton grade III Vertex (n=11), IV (n=10), and V (n=11). The treatment group consisted of patients aged 25–45 years (mean age 33.84 ± 5.14 years), with a duration of androgenetic alopecia of 2–13 years (mean duration 6.19 ± 3.04 years), and classified as Norwood-Hamilton grade III Vertex (n=11), IV (n=11), and V (n=10). Baseline characteristics were comparable between the two groups. Thirty patients from each group completed the study, with a dropout rate of 6.25%, all of whom were Norwood-Hamilton grade III Vertex patients.

[0040] Evaluation criteria: Clinical scores (sparse hair, seborrhea, dandruff, and itching), trichoscopic indicators (number of hairs, diameter, and proportion of hairs in the growth phase), endocrine indicators (uric acid, sex hormone-binding globulin, and free testosterone index) of the bald area were compared before and after treatment. Safety indicators (alanine aminotransferase, aspartate aminotransferase, and serum creatinine) were also compared.

[0041] The research results are as follows:

[0042] (1) Clinical score of bald area. Figure 1 The images show clinical photographs of the experimental group before and after treatment. After treatment, the total clinical score of the bald area in the control group significantly improved compared to before, while the scores for sparse hair and seborrhea significantly decreased, and the scores for itching and dandruff increased. Details of the scores and significance are shown in Table 1. After treatment, the total clinical score of the bald area in the experimental group significantly improved compared to before, and all individual scores decreased: the scores for sparse hair and seborrhea significantly decreased, and the scores for itching and dandruff decreased. Details of the scores and significance are shown in Table 2. Before treatment, there were no statistically significant differences in any clinical scores and the total score of the bald area between the control and experimental groups (P > 0.05), indicating comparability. After treatment, the total clinical performance score of the bald area in the experimental group was significantly better than that in the control group (P = 0.005, Z = -2.792), while there were no significant differences in the scores of the remaining items between the two groups.

[0043] Table 1 Comparison of clinical manifestation scores in the bald area before and after treatment in the control group (points, )

[0044]

[0045]

[0046] Table 2 Comparison of clinical manifestation scores of the bald area before and after treatment in the experimental group (points, )

[0047]

[0048] (2) Dermoscopy indicators. Figure 2 The images show dermoscopic photographs of the experimental group before and after treatment, revealing improvements in hair density and scalp erythema after treatment. In the control group, hair diameter and number of hairs increased significantly after treatment, while the proportion of hairs in the anagen phase remained largely unchanged. In the experimental group, hair diameter, number of hairs, and proportion of hairs in the anagen phase all increased significantly after treatment. Details are shown in Tables 3 and 4. Before treatment, there were no statistically significant differences in any of the dermoscopic indicators between the control and experimental groups (P > 0.05), indicating comparability. After treatment, the experimental group showed better results than the control group in terms of hair diameter, number of hairs, and proportion of hairs in the anagen phase, but the differences were not statistically significant (P > 0.05).

[0049] Table 3 Comparison of dermoscopy parameters before and after treatment in the control group

[0050]

[0051] Table 4 Comparison of dermoscopy parameters before and after treatment in the experimental group

[0052]

[0053] (3) Hair appearance indicators. According to the researchers' evaluation, after treatment, 3 patients in the control group had no significant improvement, 2 patients in the experimental group had no significant improvement, and the remaining patients all had varying degrees of improvement, as shown in Table 5.

[0054] Table 5 Comparison of hair appearance after treatment (cases)

[0055]

[0056] (4) Endocrine indicators. After treatment, uric acid levels decreased in both the control and experimental groups, with a significant difference observed in the experimental group. In the control group, sex hormone-binding globulin levels decreased and free testosterone levels increased after treatment, with no statistically significant difference. In the experimental group, sex hormone-binding globulin levels significantly increased and free testosterone levels decreased after treatment. See Tables 6 and 7 for details.

[0057] Table 6 Comparison of endocrine indicators before and after treatment in the control group

[0058]

[0059]

[0060] Table 6 Comparison of androgen levels before and after treatment in the experimental group

[0061]

[0062] (5) Safety indicators. No serious adverse reactions were reported in either group during the treatment period. In the control group, one patient reported nausea after taking finasteride (3.13%), and two patients reported scalp itching after applying minoxidil (6.25%). In the experimental group, one patient reported abnormal ejaculation after taking finasteride (3.13%), and one patient reported scalp itching after applying minoxidil (3.13%). Liver and kidney function levels in both groups remained within the normal range before and after treatment, with no significant difference (P>0.05).

[0063] (6) Preliminary clinical observations showed that the traditional Chinese medicine compound preparation prepared in this invention has significant therapeutic effects on androgenetic alopecia, good safety, and improves patients' seborrheic dermatitis, reduces blood uric acid levels, and improves androgen metabolism.

[0064] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A traditional Chinese medicine compound preparation for treating androgenetic alopecia, characterized in that: The dosage of each component of the raw material is as follows: 5 parts of Salvia miltiorrhiza, 6 parts of Astragalus membranaceus, 4 parts of Coix lacryma-jobi, 3 parts of Sophora flavescens, 3 parts of stir-fried Atractylodes lancea, 2 parts of Angelica sinensis, 2 parts of Glycyrrhiza uralensis, 3 parts of salt-processed Phellodendron chinense, 3 parts of Achyranthes bidentata, and 2 parts of Ligusticum chuanxiong.

2. The method for preparing the traditional Chinese medicine compound preparation for treating androgenetic alopecia according to claim 1, characterized in that: After mixing the raw materials, soak them in water for 20-40 minutes. Bring to a boil over high heat, then reduce to low heat and simmer for 40-60 minutes. Filter to obtain the liquid and dregs. Continue to boil the dregs over high heat until boiling, then reduce to low heat and simmer for 20-40 minutes. Filter again to obtain a second liquid. Combine the two liquids and concentrate them.

3. The method for preparing the traditional Chinese medicine compound preparation for treating androgenetic alopecia according to claim 2, characterized in that: The concentration of the concentrated crude drug was 1.65 g / mL.

4. The method for preparing the traditional Chinese medicine compound preparation for treating androgenetic alopecia according to claim 1, characterized in that: Boil the raw material in boiling water for 10 minutes, remove it, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract to a relative density of 1.05±0.02, centrifuge at high speed to remove impurities and purify, cool and let stand for 24 hours, take the supernatant, filter the pulp cake, concentrate to a relative density of 1.15~1.20, dispense, sterilize, and the oral liquid is obtained.

5. The method for preparing the traditional Chinese medicine compound preparation for treating androgenetic alopecia according to claim 1, characterized in that: Boil the raw material in boiling water for 10 minutes, remove it, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, pulverize it into a fine powder, add ethanol to granulate, dry it, and fill it into capsules to obtain the capsule preparation.

6. The method for preparing the traditional Chinese medicine compound preparation for treating androgenetic alopecia according to claim 1, characterized in that: Boil the raw material in boiling water for 10 minutes, remove it, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract to a relative density of 1.05±0.02, centrifuge at high speed to remove impurities and purify, cool and let stand for 24 hours, take the supernatant, filter the pulp cake, concentrate to a relative density of 1.15~1.20, spray dry, dry granulate, and package in aluminum-plastic composite film to obtain granules.

7. The method for preparing the traditional Chinese medicine compound preparation for treating androgenetic alopecia according to claim 1, characterized in that: Boil the raw drug in boiling water for 10 minutes, remove it, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, pulverize it into fine powder, add starch, granulate, and compress to obtain tablets.

8. The method for preparing the traditional Chinese medicine compound preparation for treating androgenetic alopecia according to claim 1, characterized in that: Boil the raw drug in boiling water for 10 minutes, remove it, let it steep thoroughly, add 10 times the amount of 50% ethanol, heat and reflux to extract 3 times, 1 hour each time, combine the filtrates, recover the ethanol under reduced pressure, concentrate under reduced pressure, vacuum dry the extract, pulverize it into fine powder, add refined honey, and stir the honey and drug powder in a mass ratio of 1.5:1 to prepare honey pills.

Images