Artificial bone organic template preparation mold and preparation method thereof

Abstract

The invention discloses an artificial bone organic template preparation mold and a preparation method thereof, the artificial bone organic template preparation mold comprises: a base in which a mounting space is arranged; the air hole bottom plate is mounted on the base, and a plurality of air holes are formed in the air hole bottom plate; the gasket is placed on the air hole bottom plate and covers the air holes; a plurality of uniform-section mold cavities are formed in the molding main plate, and openings are formed in the upper ends and the lower ends of the uniform-section mold cavities. And the air hole bottom plate is directly arranged in the base. The gasket is flatly laid above the air hole, and the molding main plate is pressed into the base. And organic template particles are added into the uniform-section mold cavity of the molding main plate. And after the organic template in the uniform-section mold cavity is formed, the molding main plate is detached, the gasket is removed, then the molding main plate is installed in the base again, the negative pressure of the air hole bottom plate is started, acetone is pumped out, and purified water is added to clean the organic template. Through the above steps, batch organic templates can be conveniently obtained.

Description

Technical Field

[0001] The invention relates to the technical field of artificial bone organic template preparation, in particular to an artificial bone organic template preparation mold and a preparation method thereof. Background Art

[0002] Artificial bone materials are biological materials used to replace or repair human bone tissue. They can be roughly divided into three categories: inorganic materials, organic materials, and composite materials. Organic materials are usually extracted from animal connective tissue or skin, and are protein substances that have undergone special chemical treatment, such as collagen, bone morphogenetic protein, and various osteogenic factors. These organic materials have good osteogenic induction ability because they contain osteogenic factors.

[0003] In the study of artificial bone, the use of organic templates is to provide a three-dimensional structure suitable for cell attachment and growth, while also being able to guide the formation of new bone. These organic templates are usually introduced during the synthesis process through self-assembly or other chemical means, which can control the pore size, morphology and distribution of artificial bone. The existing artificial bone organic template production steps are cumbersome and have low production efficiency. Summary of the invention

[0004] The technical problem to be solved by the present invention is: the present invention provides an artificial bone organic template preparation mold and a preparation method thereof, so as to solve the problems that the existing artificial bone organic template preparation steps are complicated and the production efficiency is low.

[0005] The technical solution adopted by the present invention to solve the technical problem is: an artificial bone organic template preparation mold, including: a base, an installation space is arranged in the base; a pore bottom plate, the pore bottom plate is installed on the base, and the pore bottom plate is provided with a plurality of pores; a gasket, the gasket is placed on the pore bottom plate and covers the plurality of pores; a molding main board, a plurality of equal-section mold cavities are arranged in the molding main board, and the upper and lower ends of the equal-section mold cavities are both open.

[0006] The beneficial effect of the present invention is that in the process of preparing the organic template, the pore bottom plate is directly installed into the base. The gasket is laid flat on top of the pore. When laying the gasket, it should be noted that the gasket must cover all the pores. After laying the gasket, the molding main board is pressed into the base. During installation, the molding main board and the gasket should be tightly attached without leaking. The organic template particles are added into the equal-section mold cavity of the molding main board without overflow. The solvent acetone is added, and after the organic template in the equal-section mold cavity is formed, the molding main board is removed and the gasket is removed, and then the molding main board is reinstalled into the base, the negative pressure of the pore bottom plate is turned on, the acetone is drained, and purified water is added to clean the organic template. After cleaning, the organic template can be obtained from the equal-section mold cavity. Through the above steps, a batch of organic templates can be easily obtained.

[0007] Preferably, it also includes: A sealing strip is provided between the air hole bottom plate and the base.

[0008] Preferably, it also includes: A guide plate, wherein the guide plate is provided with guide holes adapted to a plurality of mold cavities of equal cross-section; Ejector rod, ejector rod adapted to guide hole.

[0009] Preferably, it also includes: The positioning part is arranged at two ends of the mold main board, and the guide plate is placed on the positioning part.

[0010] Preferably, it also includes: The hand-held part is connected to the top rod, and the hand-held part is provided with anti-slip patterns.

[0011] Preferably, the cross-section of the uniform cross-section mold cavity is rectangular; Or, the cross section of the uniform cross-section cavity is arc-shaped; Or, the cross section of the uniform cross-section cavity is elliptical; Alternatively, the cross-section of the uniform-section mold cavity is a trapezoid.

[0012] Preferably, the base is overfitted to the molding base plate.

[0013] Preferably, the air hole bottom plate is connected to an air pump.

[0014] Based on another object of the present invention, the present invention provides the following technical solution: a method for preparing an artificial bone organic template, the preparation method uses the preparation mold as described above, and the preparation method comprises the following steps: S1. Install the sealing strip on the air hole bottom plate, and install the air hole bottom plate directly into the base; S2, pressing the mold main board into the base, and adding the organic template particles into the mold cavity of the mold main board with equal cross-section; S3, add solvent acetone, let it stand for a while and then remove the mold making main board; S4, after removing the gasket, reinstall the molding main board into the base, turn on the negative pressure, drain the acetone and add purified water to clean the organic template; S5. After cleaning, remove the mold main board, install the guide plate just above the mold main board, and use the ejector pin to push out the organic template.

[0015] Preferably, the material of the organic template particles is PMMA, and the particle size of the organic template particles is 500 μm. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 A schematic diagram of the three-dimensional structure of a mold for preparing an artificial bone organic template; Figure 2 A cross-sectional view of preparing a mold for an artificial bone organic template; Figure 3 for Figure 2 A partial enlarged view of point A in the middle.

[0017] In the figure: base 1, sealing strip 2, air hole 3, organic template 4, uniform cross-section cavity 5, ejector rod 6, handle 7, guide hole 8, guide plate 9, molding main board 11, gasket 12, air hole bottom plate 13, installation space 14, positioning part 15. DETAILED DESCRIPTION

[0018] In order to enable those skilled in the art to better understand the solution of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0019] In this article, the terms "upper, lower, inside, outside" and the like are established based on the positional relationships shown in the drawings. The corresponding positional relationships may also change depending on the drawings, and therefore cannot be understood as absolute limitations on the scope of protection; moreover, relational terms such as "first" and "second" and the like are merely used to distinguish one component from another with the same name, and do not necessarily require or imply any actual relationship or order between these components.

[0020] Embodiment 1 like Figure 1-3 As shown, this embodiment provides an artificial bone organic template preparation mold, including: a base 1, in which an installation space 14 is arranged; a pore 3 bottom plate, which is installed on the base 1, and the pore 3 bottom plate is provided with a plurality of pores 3; a gasket 12, which is placed on the pore 3 bottom plate and covers a plurality of pores 3; a molding main board 11, in which a plurality of equal-section mold cavities 5 are arranged, and the upper and lower ends of the equal-section mold cavities 5 are both open.

[0021] Specifically, in the process of preparing the organic template 4, the bottom plate of the pore 3 is directly installed into the base 1. The gasket 12 is laid flat on the top of the pore 3. When laying the gasket 12, it should be noted that the gasket 12 must cover all the pores 3. After laying the gasket 12, the molding main board 11 is pressed into the base 1. During installation, the molding main board 11 and the gasket 12 should be tightly attached without water leakage. Add the organic template 4 particles into the equal-section mold cavity 5 of the molding main board 11 without overflow. Add the solvent acetone, and after the organic template 4 in the equal-section mold cavity 5 is formed, remove the molding main board 11 and remove the gasket 12, and then reinstall the molding main board 11 into the base 1, open the negative pressure of the bottom plate of the pore 3, drain the acetone, and add purified water to clean the organic template 4. After cleaning, the organic template 4 can be obtained from the equal-section mold cavity 5. Through the above steps, a batch of organic templates 4 can be easily obtained.

[0022] Furthermore, it also includes: a sealing strip 2, and a sealing strip 2 is arranged between the bottom plate of the air hole 3 and the base 1. The sealing strip 2 is first installed on the bottom plate of the air hole 3, and then the bottom plate of the air hole 3 with the sealing strip 2 is directly installed into the base 1. The sealing is ensured and the suction effect is improved when the bottom plate of the air hole 3 is opened to generate negative pressure.

[0023] Furthermore, it also includes: a guide plate 9, which is provided with guide holes 8 adapted to a plurality of equal-section mold cavities 5; and a push rod 6, which is adapted to the guide holes 8. The guide holes 8 are also through holes, which penetrate the guide plate 9 along the height of the guide plate 9. After the organic template 4 is cleaned, the molding main board 11 is removed, and the guide plate 9 is installed directly above the molding main board 11, and the guide holes 8 are aligned with the equal-section mold cavities 5 of the molding main board 11, and the organic template 4 in the equal-section mold cavities 5 is ejected with the push rod 6. The arrangement of the guide plate 9 and the push rod 6 makes it easier to eject the organic template 4.

[0024] Furthermore, it also includes: Positioning part 15, the positioning part 15 is arranged at both ends of the mold main board 11, and the guide plate 9 is placed on the positioning part 15. The positioning part 15 is a stepped square groove, and the shape and size of the positioning part 15 just match the guide plate 9, that is, the guide plate 9 can just fit into the positioning part 15. When the guide plate 9 is placed on the positioning part 15, the guide hole 8 of the guide plate 9 is aligned with the uniform cross-section mold cavity 5 of the mold main board 11. By setting the positioning part 15, it is more convenient to align the uniform cross-section mold cavity 5 with the guide hole 8.

[0025] Furthermore, it also includes a handheld portion 7, which is connected to the ejector rod 6 and has anti-slip patterns. In order to facilitate ejection of the organic template 4 through the ejector rod 6, the handheld portion 7 is specially provided to facilitate the relevant staff to hold it. Of course, the handheld portion 7 can also be connected to a power source to realize automatic ejection of the organic template 4.

[0026] Further, the cross section of the uniform cross-section mold cavity 5 is rectangular; or, the cross section of the uniform cross-section mold cavity 5 is arc-shaped; or, the cross section of the uniform cross-section mold cavity 5 is elliptical; or, the cross section of the uniform cross-section mold cavity 5 is trapezoidal. The specific cross section of the uniform cross-section mold cavity 5 is not limited here, and can be selected according to actual conditions. Preferably, the cross section of the uniform cross-section mold cavity 5 is rectangular.

[0027] Furthermore, the base 1 is overfitted with the mold main board 11. The mold main board 11 needs to be pressed into the base 1 by external force, and after being pressed in, the position of the mold main board 11 will not change easily.

[0028] Furthermore, the bottom plate of the air hole 3 is connected to an air pump, and the air pump is used to provide suction force.

[0029] Embodiment 2 The same parts in this embodiment as those in the first embodiment are given the same figure marks, and the same text descriptions are omitted.

[0030] This embodiment discloses a method for preparing an artificial bone organic template. The preparation method uses the preparation mold in Embodiment 1, and the preparation method comprises the following steps: S1, install the sealing strip 2 on the bottom plate of the air hole 3, and install the bottom plate of the air hole 3 directly into the base 1; S2, the molding main board 11 is pressed into the base 1, and the organic template 4 particles are added into the uniform cross-section mold cavity 5 of the molding main board 11; S3, adding solvent acetone, leaving it to stand for a while and then removing the molding main board 11; S4, after removing the gasket 12, reinstall the molding main board 11 into the base 1, turn on the negative pressure, drain the acetone and add purified water to clean the organic template 4; S5. After cleaning, remove the mold main board 11, install the guide plate 9 just above the mold main board 11, and use the ejector rod 6 to eject the organic template 4.

[0031] Specifically, the preparation method of the organic template 4 is as follows: add organic template 4 particles to the uniform cross-section mold cavity 5 of the mold main board 11, and the organic template 4 particles cannot overflow the surface, and then add 75% concentration of acetone solvent to the uniform cross-section mold cavity 5. Soak for 3-4 minutes. Turn on the air pump, drain the acetone solvent through the bottom plate of the air hole 3, and add purified water to clean the acetone. Finally, the organic template 4 is pushed out of the mold main board 11 by the ejector rod 6. After the organic template 4 is taken out, it is soaked in purified water for 5 minutes. After soaking, the organic template 4 is taken out and put into an oven for drying. The drying temperature is 60 degrees and the drying time is 2 hours.

[0032] Furthermore, the material of the organic template 4 particles is PMMA, and the particle size of the organic template 4 particles is 500 μm.

[0033] The above-mentioned technical features can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

Claims

1. A mold for preparing an artificial bone organic template, It is characterized in that include: A base (1), wherein an installation space (14) is provided in the base (1); An air hole (3) bottom plate, the air hole (3) bottom plate being mounted on the base (1), the air hole (3) bottom plate being provided with a plurality of air holes (3); A gasket (12), the gasket (12) being placed on the bottom plate of the air holes (3) and covering a plurality of the air holes (3); A moulding main board (11), wherein a plurality of mould cavities (5) with equal cross-sections are arranged in the moulding main board (11), and the upper and lower ends of the mould cavities (5) with equal cross-sections are both open.

2. The artificial bone organic template preparation mold according to claim 1, It is characterized in that Also includes: A sealing strip (2) is provided between the bottom plate of the air hole (3) and the base (1).

3. The artificial bone organic template preparation mold according to claim 1, It is characterized in that Also includes: A guide plate (9), wherein the guide plate (9) is provided with guide holes (8) adapted to fit a plurality of the mold cavities (5) of equal cross-section; A push rod (6), wherein the push rod (6) is adapted to fit the guide hole (8).

4. The artificial bone organic template preparation mold according to claim 3, It is characterized in that Also includes: Positioning parts (15), the positioning parts (15) are arranged at two ends of the mold making main board (11), and the guide plate (9) is placed on the positioning parts (15).

5. The artificial bone organic template preparation mold according to claim 3, It is characterized in that Also includes: A hand-held portion (7), the hand-held portion (7) being connected to the push rod (6), and the hand-held portion (7) being provided with anti-slip patterns.

6. The artificial bone organic template preparation mold according to claim 1, It is characterized in that The cross section of the uniform cross-section mold cavity (5) is rectangular; Or, the cross section of the uniform cross-section mold cavity (5) is arc-shaped; Or, the cross section of the uniform cross-section mold cavity (5) is elliptical; Alternatively, the cross-section of the uniform-section mold cavity (5) is trapezoidal.

7. The artificial bone organic template preparation mold according to claim 1, It is characterized in that The base (1) and the mold making main board (11) are overfitted.

8. The artificial bone organic template preparation mold according to claim 1, It is characterized in that The bottom plate of the air hole (3) is connected to an air pump.

9. A method for preparing an artificial bone organic template, the method using the preparation mold according to any one of claims 1 to 8, It is characterized in that The preparation method comprises the following steps: S1. Install the sealing strip (2) on the bottom plate of the air hole (3), and install the bottom plate of the air hole (3) directly into the base (1); S2, pressing the mold main board (11) into the base (1), adding the organic template (4) particles into the mold cavity (5) of the mold main board (11) with a uniform cross section; S3, adding solvent acetone, leaving it to stand for a period of time and then removing the mold making main board (11); S4, after removing the gasket (12), reinstall the mold-making main board (11) into the base (1), turn on the negative pressure, drain the acetone and add purified water to clean the organic template (4); S5. After cleaning, remove the mold main board (11), install the guide plate (9) just above the mold main board (11), and use the ejector rod (6) to eject the organic template (4).

10. The method for preparing an artificial bone organic template according to claim 9, It is characterized in that The material of the organic template (4) particles is PMMA, and the particle size of the organic template (4) particles is 500 μm.

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