Acne-removing face cream and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, in particular to the field of IPC A61K8, and further relates to acne-removing face cream and a preparation method thereof. The skin conditioner comprises the following raw materials in percentage by mass: 3-12% of an emulsifier, 2-10% of an emollient, 1-5% of a first skin conditioner, 0.5-5% of a polyhydroxy compound, 0.5-2% of a second skin conditioner, 0.5-2% of a neutralizer, 0.1-1% of a third skin conditioner, 0.05-1% of a thickener, 0.05-0.2% of a freshener, 0.01-0.1% of a chelating agent and the balance of deionized water. On one hand, the face cream disclosed by the invention can mildly remove acnes by reducing the adhesion of keratinocytes; white heads are removed; on the other hand, inflammation and red and swollen conditions can be relieved, release of inflammatory factors is reduced, and then deterioration of acnes is prevented.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, in particular to the field of IPC A61K8, and further to an anti-acne cream and a preparation method thereof. Background Art

[0002] "Acne" is the common name for acne, also known as "pimples", "blackheads" or "blackheads". It is a skin disease caused by blockage and inflammation of hair follicles and sebaceous glands.

[0003] In order to remove acne, some people will use the squeezing "needle cleaning" method, but needle cleaning only squeezes out the things on the surface of the skin, while the inflammation in the underlying skin remains, and it cannot fundamentally solve the problem.

[0004] To solve the above problems, Chinese patent CN 202311224622 discloses an acne-removing essence, including water, ethanol, glycerin, p-nitrobenzaldehyde, 4-aminomethyl-2-methoxyphenol, metronidazole, pyridoxine, palmitic acid, stearic acid, and dimetridazole; the proportions are 73.8%, 9.4%, 7.3%, 0.1%, 0.1%, 3.6%, 0.1%, 0.2%, 0.1%, and 5.3%, respectively; however, the metronidazole present therein may irritate the skin and cause contact dermatitis if used for a long time. Summary of the invention

[0005] To solve the above technical problems, the first aspect of the present invention provides an acne-removing cream. The raw materials include, by mass percentage: 3-12% emulsifier, 2-10% emollient, 1-5% first skin conditioner, 0.5-5% polyhydroxy compound, 0.5-2% second skin conditioner, 0.5-2% neutralizer, 0.1-1% third skin conditioner, 0.05-1% thickener, 0.05-0.2% cooling agent, 0.01-0.1% chelating agent, and the balance deionized water.

[0006] Preferably, the emulsifier is selected from at least one of cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate, cetearyl alcohol, polyacrylamide / C13-14 isoparaffin / laureth-7.

[0007] Preferably, the emulsifier includes emulsifier A and emulsifier B.

[0008] Preferably, the mass ratio of the emulsifier A to the emulsifier B is (6-8):(1-2).

[0009] Preferably, the emulsifier A includes cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol.

[0010] Preferably, the mass ratio of cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol is (1-2):(1-3):(3-5).

[0011] Preferably, the mass ratio of cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol is (1-2):(1.5-2.5):(3-4).

[0012] Preferably, the emulsifier B is polyacrylamide / C13-14 isoparaffin / laureth-7.

[0013] Preferably, the emollient is selected from at least one of cyclopentasiloxane, dimethicone, octylmethicone and hexasiloxane.

[0014] Preferably, the emollient is a combination of cyclopentasiloxane and polydimethylsiloxane.

[0015] Preferably, the mass ratio of cyclopentasiloxane to polydimethylsiloxane is (1-2): (1-2).

[0016] Preferably, the first skin conditioning agent is selected from at least one of salicylic acid and salicylic acid derivatives.

[0017] Preferably, the first skin conditioning agent is a salicylic acid derivative.

[0018] Preferably, the salicylic acid derivative is selected from capryloyl salicylic acid, betaine salicylate

[0019] Preferably, the salicylic acid derivative is betaine salicylate.

[0020] Preferably, the polyhydroxy compound is selected from at least one of 1,3-butanediol, 1,2-hexanediol, propylene glycol, glycerol, ethylhexylglycerol, dipropylene glycol, and glycerol.

[0021] Preferably, the polyol is a combination of propylene glycol and ethylhexylglycerin.

[0022] Preferably, the mass ratio of propylene glycol to ethylhexylglycerin is (2-4):(0.2-0.5).

[0023] Preferably, the second skin conditioning agent is a phenol derivative.

[0024] Preferably, the phenol derivative is 3-methyl-4-isopropylphenol.

[0025] Preferably, the neutralizing agent is triethanolamine.

[0026] Preferably, the third skin conditioning agent is selected from at least one of polyquaternium-73, polyquaternium-51, and dihydrooat alkaloids.

[0027] Preferably, the third skin conditioning agent is dihydroavenous alkaloid.

[0028] Preferably, the mass ratio of the first skin conditioner, the second skin conditioner and the third skin conditioner is (1-2.5):(1-2):(0.1-1).

[0029] Preferably, the mass ratio of the first skin conditioner, the second skin conditioner and the third skin conditioner is (1.5-2.5): (1.5-2): (0.3-0.6).

[0030] In the present application, a first skin conditioner is introduced, especially when the first skin conditioner is betaine salicylic acid, it is milder than salicylic acid and has a certain acne-removing effect. In order to further expand the acne-removing pathway of the cream, the present application introduces a second skin conditioner and a third skin conditioner. However, the applicant found that when the third skin conditioner is a polyquaternium salt, the compatibility of the system is extremely poor, and even a stable cream cannot be formed; when the third conditioner is a dihydrooat alkaloid, this problem can be avoided, and the prepared cream can not only have a significant removal effect on acne and papules, but also can exist stably. The applicant speculates that this is because the polyquaternium salt has cations in its structure, and the thickener carbomer in the present application has negatively charged groups in its structure, which leads to a decrease in the viscosity of the system and even the formation of salt substances, resulting in the inability of the cream to exist stably; and the dihydrooat alkaloid of the present application is anionic, which not only does not affect the thickening effect of carbomer, but also can increase the electrostatic repulsion between the ions of the system, thereby improving the stability of the cream.

[0031] In addition, the applicant also found that the mass ratio of the first skin conditioner, the second skin conditioner and the third skin conditioner needs to be controlled to be (1-2.5): (1-2): (0.1-1); especially when the mass ratio of the first skin conditioner, the second skin conditioner and the third skin conditioner is (1.5-2.5): (1.5-2): (0.3-0.6), the acne removal effect and stability of the facial cream are the best; and when the mass ratio of the first skin conditioner, the second skin conditioner and the third skin conditioner is not within the range of (1-2.5): (1-2): (0.1-1), the facial cream becomes thinner.

[0032] Preferably, the thickener is selected from at least one of a natural thickener and a synthetic thickener.

[0033] Preferably, the thickener includes natural thickeners and synthetic thickeners.

[0034] Preferably, the mass ratio of the natural thickener to the synthetic thickener is 1:(1-3).

[0035] Preferably, the natural thickener is selected from at least one of starch, xanthan gum and guar gum.

[0036] Preferably, the natural thickener is xanthan gum.

[0037] Preferably, the synthetic thickener is selected from at least one of carbomer, methyl cellulose and hydroxyethyl cellulose.

[0038] Preferably, the synthetic thickener is carbomer.

[0039] Preferably, the carbomer is carbomer 940.

[0040] Preferably, the cooling agent is selected from at least one of menthol, menthol derivatives, and peppermint oil.

[0041] Preferably, the cooling agent is menthol.

[0042] Preferably, the chelating agent is EDTA-2Na.

[0043] A second aspect of the present invention provides a method for preparing an anti-acne cream, comprising the following steps:

[0044] S1. Weigh each raw material according to mass percentage;

[0045] S2, heating and dissolving the first skin conditioning agent, 85-90% of the neutralizing agent, and 8-10% of deionized water for later use;

[0046] S3, heating the thickener, chelating agent, polyol and remaining deionized water to 80-85° C. at a rotation speed of 25-35 r / min to obtain an aqueous phase;

[0047] S4, heating the first emulsifier and the cooling agent to 80-85° C. at a rotation speed of 25-35 r / min to obtain an oil phase;

[0048] S5. Turn on the vacuum pump switch, draw the vacuum degree in the emulsifying pot to below -0.04 MPa, draw the water phase into the emulsifying pot at a stirring speed of 15-25 r / min, defoam and draw in phase B at 55-65 r / min, homogenize at 80-85°C for 4-7 minutes; then turn on the cooling water to cool down to 80°C;

[0049] S6, add the second emulsifier and emulsifier, homogenize for 2 to 4 minutes; stir and defoam at a constant temperature, and after defoaming, stir with cooling water (30r / min) to cool down;

[0050] S7, 75℃ vacuum -0.04MPa;

[0051] S8, add the mixture of S2 and the remaining neutralizer at 60°C and stir evenly;

[0052] S9, adding the second conditioning agent and the third conditioning agent at 45°C and stirring evenly;

[0053] S10, vacuum filter and discharge the material at below 38℃.

[0054] Beneficial effects:

[0055] 1. The present application adopts propylene glycol and ethylhexylglycerin in a mass ratio of (2-4): (0.2-0.5) to improve the anti-acne effect of the anti-acne cream while giving the cream moisturizing properties, and does not require the addition of additional preservatives to prevent the moisturizing cream from being contaminated by microorganisms; at the same time, it also avoids the problem of precipitation of the third skin conditioning agent 3-methyl-4-isopropylphenol in the cream.

[0056] 2. In the present application, a natural thickener and a synthetic thickener are introduced to act together, especially when the natural thickener is xanthan gum and the synthetic thickener is carbomer 940, the prepared acne cream has a suitable viscosity and a light sticky feeling, which avoids clogging of pores and poor acne removal effect.

[0057] 3. In the present application, when the third conditioning agent is dihydrooatmeal alkaloid, the compatibility problem of the system can be avoided, and the prepared facial cream can not only have a significant effect on removing acne and papules, but also can exist stably.

[0058] 4. The present application controls the mass ratio of the first skin conditioner, the second skin conditioner and the third skin conditioner to be (1-2.5): (1-3): (0.1-1); especially when the mass ratio of the first skin conditioner, the second skin conditioner and the third skin conditioner is (1.5-2.5): (1.5-2.5): (0.3-0.6), the acne removal effect and stability of the facial cream are the best.

[0059] 5. The cream of the present application can, on the one hand, reduce the adhesion of keratinocytes and gently remove acne and whiteheads; on the other hand, it can relieve inflammation, redness and swelling, reduce the release of inflammatory factors, and thus prevent the deterioration of acne. BRIEF DESCRIPTION OF THE DRAWINGS

[0060] Figure 1 This is a test scheme for the anti-acne performance of the anti-acne cream prepared in Example 1.

[0061] Figure 2 This is a test step for the acne-removing performance of the acne-removing cream prepared in Example 1.

[0062] Figure 3This is a graph showing the acne-removing performance of the acne-removing cream prepared in Example 1.

[0063] Figure 4 This is a photo of the acne-removing cream prepared in Example 1 used by subject No. 08.

[0064] Figure 5 This is a photo of the acne-removing cream prepared in Example 1 used by subject No. 10.

[0065] Figure 6 This is a photo of the anti-acne cream prepared in Example 1 used by Subject No. 18. DETAILED DESCRIPTION

[0066] The trade name of cetearyl glucoside / oleic acid ester used in the examples of the present application is EMULPHARMA1000, the trade name of glyceryl stearate / PEG-100 stearate is 165; the trade name of cetearyl alcohol is 16.18 alcohol; betaine salicylate was purchased from Guangdong Gexin Biotechnology Co., Ltd., model: NMB-150; polyacrylamide / C13-14 isoparaffin / laureth-7 trade name is 305; cyclopentasiloxane The trade name of dimethicone is DC342; the trade name of polydimethylsiloxane is DC200; 3-methyl-4-isopropylphenol was purchased from Guangdong GeXen Biotechnology Co., Ltd., model NB-172 (INCI: butylene glycol, 1,2-pentanediol, 3-methyl-4-isopropylphenol); dihydroavenate alkaloids were purchased from Guangdong GeXen Biotechnology Co., Ltd., model NB-325 (INCI: butylene glycol, 1,2-pentanediol, dihydroavenate alkaloids).

[0067] Example 1

[0068] Example 1 provides an anti-acne facial cream, which includes, by mass percentage, 8.5% of emulsifier, 4% of moisturizer, 2% of first skin conditioner, 3.3% of polyol, 2% of second skin conditioner, 1.6% of neutralizer, 0.5% of third skin conditioner, 0.3% of thickener, 0.1% of cooling agent, 0.02% of chelating agent, and the balance of deionized water.

[0069] The emulsifier includes emulsifier A and emulsifier B.

[0070] The mass ratio of the emulsifier A to the emulsifier B is 7.3:1.2.

[0071] The emulsifier A includes cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol.

[0072] The mass ratio of cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate and cetearyl alcohol is 1.5:2:3.8.

[0073] The emulsifier B is polyacrylamide / C13-14 isoparaffin / laureth-7.

[0074] The emollient is a combination of cyclopentasiloxane and dimethicone.

[0075] The mass ratio of the cyclopentasiloxane to polydimethylsiloxane is 1:1.

[0076] The first skin conditioning agent is a salicylic acid derivative; and the salicylic acid derivative is betaine salicylate.

[0077] The polyol is a combination of propylene glycol and ethylhexylglycerin.

[0078] The mass ratio of the propylene glycol to ethylhexylglycerin is 3:0.3.

[0079] The second skin conditioning agent is a phenol derivative.

[0080] The phenol derivative is 3-methyl-4-isopropylphenol.

[0081] The neutralizing agent is triethanolamine.

[0082] The third skin conditioning agent is dihydroavenous alkaloid.

[0083] The thickener includes natural thickeners and synthetic thickeners.

[0084] The mass ratio of the natural thickener to the synthetic thickener is 1:2.

[0085] The natural thickener is xanthan gum.

[0086] The synthetic thickener is carbomer.

[0087] The carbomer is carbomer 940.

[0088] The cooling agent is menthol.

[0089] The chelating agent is EDTA-2Na.

[0090] A method for preparing an anti-acne facial cream comprises the following steps:

[0091] S1. Weigh each raw material according to mass percentage;

[0092] S2, heating and dissolving the first skin conditioning agent, 87.5% of the neutralizing agent, and 9.9% of deionized water for later use;

[0093] S3, heating the thickener, chelating agent, polyol and remaining deionized water to 85° C. at a rotation speed of 30 r / min to obtain an aqueous phase;

[0094] S4, heating the first emulsifier and the cooling agent to 85° C. at a rotation speed of 30 r / min to obtain an oil phase;

[0095] S5. Turn on the vacuum pump switch, draw the vacuum degree in the emulsifying pot to below -0.04 MPa, draw the water phase into the emulsifying pot at a stirring speed of 20 r / min, defoam and draw in phase B at 60 r / min, and homogenize at 85°C for 5 minutes; then turn on the cooling water to cool down to 80°C;

[0096] S6, add the second emulsifier and emulsifier, homogenize for 3 minutes; stir and defoam at constant temperature, and after defoaming, stir with cooling water (30r / min) to cool down;

[0097] S7, 75℃ vacuum -0.04MPa;

[0098] S8, add the mixture of S2 and the remaining neutralizer at 60°C and stir evenly;

[0099] S9, adding the second conditioning agent and the third conditioning agent at 45°C and stirring evenly;

[0100] S10, vacuum filter and discharge the material at below 38℃.

[0101] Performance Testing:

[0102] 1. Stability: See the table below for test methods and results.

[0103]

[0104] 2. Acne-removing effect:

[0105] Test plan see Figure 1 ; The Qingji Anti-acne Cream in the figure refers to the anti-acne cream prepared in Example 1 of the present application;

[0106] Test steps see Figure 2 ;

[0107] Test results see Figure 3 .

[0108] Some photos of the subjects can be found in Figures 4 to 6 .

Claims

1. An anti-acne cream, characterized in that: Calculated by mass percentage, the raw materials include: 3-12% emulsifier, 2-10% moisturizer, 1-5% first skin conditioner, 0.5-5% polyhydroxy compound, 0.5-2% second skin conditioner, 0.5-2% neutralizer, 0.1-1% third skin conditioner, 0.05-1% thickener, 0.05-0.2% cooling agent, 0.01-0.1% chelating agent, and the balance deionized water.

2. The anti-acne cream according to claim 1, characterized in that The emulsifier is selected from at least one of cetearyl glucoside / sorbitan olivate, glyceryl stearate / PEG-100 stearate, cetearyl alcohol, polyacrylamide / C13-14 isoparaffin / laureth-7.

3. The anti-acne cream according to claim 1, characterized in that The emollient is selected from at least one of cyclopentasiloxane, dimethicone, octylmethicone and hexasiloxane.

4. The anti-acne cream according to claim 1, characterized in that The first skin conditioning agent is selected from at least one of salicylic acid and salicylic acid derivatives.

5. The anti-acne cream according to claim 4, characterized in that: The salicylic acid derivative is selected from capryloyl salicylic acid and betaine salicylate.

6. The anti-acne cream according to claim 1, characterized in that: The polyhydroxy compound is selected from at least one of 1,3-butanediol, 1,2-hexanediol, propylene glycol, glycerol, ethylhexylglycerol, dipropylene glycol, and glycerol.

7. The anti-acne cream according to claim 1, characterized in that: The second skin conditioning agent is a phenol derivative.

8. The anti-acne cream according to claim 1, characterized in that: The third skin conditioning agent is selected from at least one of polyquaternium-73, polyquaternium-51, and dihydroavenate alkaloids.

9. The anti-acne cream according to claim 1, characterized in that: The mass ratio of the first skin conditioner, the second skin conditioner and the third skin conditioner is (1-2.5):(1-2):(0.1-1).

10. A method for preparing the anti-acne cream according to claim 1, characterized in that: The following steps are involved: The raw materials are uniformly mixed according to mass percentage.

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