Composition for treating male physiological disorders and preparation method thereof

Abstract

The embodiment of the invention discloses a composition for treating male physiological disorders and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The composition is prepared from the following raw materials in parts by weight: 0.1 to 0.7 part of radix aconiti carmichaeli, 0.05 to 0.5 part of flos caryophylli, 0.09 to 0.3 part of herba epimedii, 0.1 to 0.6 part of semen strychni, 0.1 to 0.6 part of herba cistanche, 0.05 to 0.5 part of fructus cnidii and 0.05 to 0.5 part of fructus gleditsiae. The composition is in the form of a patch, is used for treating male physiological disorders, and is applied to a specific acupuncture point of a human body; the specific acupuncture points of the human body comprise the Mingmen point and the Shenshu point. All the raw materials have respective strong effects and have no conflicts and contraindications, so that when the raw materials are mixed for use, not only can the advantages of the medicines be maximized and the effect of treating the impotence be exerted, but also the side effects of the medicines or the blocking of the effects of the medicines are avoided, and the curative effect of the medicines is improved. And the overall treatment effect can be better exerted.

Description

Technical Field

[0001] The embodiments of the present invention relate to the technical field of traditional Chinese medicine, and in particular to a composition for treating male physiological disorders and a preparation method thereof. Background Art

[0002] With the development of the times and the improvement of people's living standards, male sexual dysfunction has become one of the hot topics of social concern. According to incomplete statistics, 10%-15% of adult men in my country suffer from severe impotence, and 10%-15% suffer from mild impotence; while foreign reports believe that more than 10% of adults suffer from impotence; it is also reported that the proportion of impotence patients is significantly positively correlated with the proportion of the population, and the incidence rate increases with the age of the person. Therefore, it can be seen that among adults in my country, those suffering from impotence of varying degrees account for about 20%-30% of the total number.

[0003] The existing Chinese medicine formula includes the following raw materials in parts by weight: 15-28 parts of Herba Epimedii, 8-18 parts of Herba Epimedii, 1.1-1.9 parts of Rhizoma Anemarrhenae, 3-9 parts of Rhizoma Cynoglossi, 18-38 parts of Rhizoma Polygonati, 15-25 parts of Rehmannia glutinosa, 2-8 parts of Radix Aconiti Lateralis, 15-25 parts of Rhizoma Dioscoreae, 1-6 parts of Licorice, and 2-6 parts of Cinnamon Bark; the above components are mixed evenly in proportion to form tablets, which have the effects of improving kidney essence, replenishing essence and nourishing marrow, significantly improving desire, increasing the number of erections and prolonging the duration of erections, thereby solving the symptoms of male impotence and premature ejaculation. However, the invention has some side effects during use, such as dry mouth, dark urine, nausea and vomiting, and can also cause liver damage, so it is not suitable for large-scale promotion and use. Summary of the invention

[0004] To this end, the embodiments of the present invention provide a composition for treating male physiological disorders and a preparation method thereof, so as to solve the problem of side effects such as dry mouth, dark urine, nausea, vomiting and liver damage during use caused by imperfections in the prior art.

[0005] In order to achieve the above purpose, the embodiment of the present invention provides the following technical solutions:

[0006] According to a first aspect of an embodiment of the present invention, the present invention provides a method for preparing a composition for treating male physiological disorders, the preparation method comprising the following steps:

[0007] S1: Weigh the following raw materials in the following weight ratio:

[0008] 0.1-0.7 parts of aconite root, 0.05-0.5 parts of cloves, 0.09-0.3 parts of epimedium, 0.1-0.6 parts of strychnos nux vomica, 0.1-0.6 parts of cistanche deserticola, 0.05-0.5 parts of cnidium monnieri, and 0.05-0.5 parts of sapodilla; wash all the raw materials with water and soak them for later use;

[0009] S2: Put all the raw materials in a pot, add water and heat to boiling, adjust the temperature and perform the first decoction, filter out the raw material residue and retain the first filtrate, repeat the above steps with the raw material residue and perform the second decoction, filter the raw material residue and obtain the second filtrate;

[0010] S3: combining the first filtrate and the second filtrate obtained in step S2 and concentrating them;

[0011] S4: Add pure grain wine to the concentrated filtrate obtained in step S3 and concentrate.

[0012] Furthermore, in step S1, the soaking conditions are: temperature 30-40°C, time 30-40min.

[0013] Furthermore, in step S2, the conditions for the first decoction are temperature 70-90°C and time 30-60 min; the conditions for the second decoction are temperature 80-100°C and time 20-30 min.

[0014] Further, in step S3, the filtrate is concentrated to 2 / 5 of the volume of the combined filtrate.

[0015] Furthermore, in step S4, the volume ratio of the pure grain wine to the concentrated filtrate is 1:1.

[0016] Furthermore, in step S4, the volume is concentrated to 1 / 2 of the total volume of the pure grain wine and the combined filtrate.

[0017] Furthermore, in step S4, the pure grain wine is sorghum wine or millet wine.

[0018] According to a second aspect of an embodiment of the present invention, the present invention provides a composition for treating male physiological disorders, which is prepared by the above-mentioned preparation method;

[0019] The composition comprises the following raw materials in parts by weight: The composition comprises the following raw materials in parts by weight: 0.4 parts of aconite root, 0.3 parts of cloves, 0.1 parts of epimedium, 0.3 parts of strychnos nux vomica, 0.3 parts of Cistanche deserticola, 0.1 parts of Cnidium monnieri and 0.2 parts of Gleditsia sinensis.

[0020] Among them, aconite is the main medicine for warming yang and invigorating fire. It is mainly used to treat spleen and kidney deficiency and cold, bladder cold, waist and knee pain, slow fright in children, cold abdomen in women, long-term infertility, wind-cold and weak feet, cold accumulation in the heart and abdomen, sudden cold and pain in the yin and yang, hard masses, cold phlegm and asthma, incontinence, frequent urination from the kidneys, leucorrhea, abdominal distension and cold diseases; clove can inhibit excitement, contract blood vessels and relax bronchial smooth muscles; epimedium can enhance the body's immune function and nourish the liver and kidneys to make the body stronger; strychnine is used for swelling and pain caused by trauma, rheumatic arthralgia, muscle and bone cramps, and hemiplegia; it also has a cardiotonic and diuretic effect, and can also promote the absorption of the small intestine and the utilization of glucose in the body, thereby improving the body's endurance and anti-fatigue. ability; Cistanche has a good kidney-nourishing effect, and can replenish cell moisture, enhance cell antioxidant capacity, reduce free radical formation, and also prevent lipid oxidation and delay aging; and Cnidium monnieri has the effect of drying dampness and dispelling wind, killing insects and relieving itching. It has a good effect on stubborn skin diseases, such as neurodermatitis, chronic eczema and psoriasis, etc. It can also relieve skin itching caused by allergic reactions. It can also be used to treat symptoms such as urinary problems caused by gynecological inflammation, and can also prevent and treat symptoms such as colds, fever, headaches and coughs; Gleditsia sinensis is mainly used to treat phlegm, cough, asthma, lockjaw due to stroke, excessive phlegm, coma, epilepsy, laryngeal paralysis, constipation, carbuncle, scabies and tinea.

[0021] Furthermore, the composition is in the form of a patch, which is used to treat male physiological disorders and is applied to specific acupuncture points of the human body;

[0022] The specific acupuncture points of the human body include Mingmen acupoint and Shenshu acupoint.

[0023] The embodiments of the present invention have the following advantages:

[0024] 1. All the raw materials of the present invention have their own strong effects and there is no conflict between them. Therefore, mixing them together can not only maximize the advantages of these drugs, but also play the effect of treating impotence;

[0025] 2. The dosage form of the present invention is a patch. Compared with the traditional oral Chinese medicine formula, it avoids the side effects or blocking of each other's effects, and the patient's medication compliance is strong, which is more conducive to exerting the overall therapeutic effect;

[0026] 3. The present invention has a wide range of applications and is suitable for patients of different age groups. It can not only effectively overcome various reproductive system problems caused by aging or long-term bad living habits, but also play a good preventive health care role, and has strong practicality and promotion value. DETAILED DESCRIPTION

[0027] The following is a description of the implementation of the present invention by specific embodiments. People familiar with the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] Example 1

[0029] This embodiment provides a composition for treating male physiological disorders, which comprises the following raw materials by weight: 0.4 parts of aconite root, 0.3 parts of cloves, 0.1 parts of epimedium, 0.3 parts of strychnos nux vomica, 0.3 parts of Cistanche deserticola, 0.1 parts of Cnidium monnieri, and 0.2 parts of Gleditsia sinensis.

[0030] The preparation method comprises the following steps:

[0031] S1: Wash all raw materials with water and soak them at 30℃ for 30min for later use;

[0032] S2: Put all the raw materials in a pot, add water and heat to boiling, adjust the temperature to 70°C and perform the first decoction for 60 minutes, filter out the raw material residue and retain the first filtrate, repeat the above steps with the raw material residue and perform the second decoction at 80°C for 30 minutes, filter the raw material residue and obtain the second filtrate;

[0033] S3: combining the first filtrate and the second filtrate obtained in step S2, and concentrating the mixture to 2 / 5 of the volume of the combined filtrate;

[0034] S4: Add the same volume of kaoliang wine to the concentrated filtrate obtained in step S3 and concentrate to 1 / 2 of the total volume.

[0035] Example 2

[0036] This embodiment provides a composition for treating male physiological disorders, which comprises the following raw materials in parts by weight: 0.7 parts of aconite root, 0.5 parts of cloves, 0.3 parts of epimedium, 0.6 parts of strychnos nux vomica, 0.6 parts of Cistanche deserticola, 0.5 parts of Cnidium monnieri, and 0.5 parts of Gleditsia sinensis.

[0037] The preparation method comprises the following steps:

[0038] S1: Wash all raw materials with water and soak them at 40℃ for 40min for later use;

[0039] S2: Put all the raw materials in a pot, add water and heat to boiling, adjust the temperature to 90°C and perform the first decoction for 30 minutes, filter out the raw material residue and retain the first filtrate, repeat the above steps with the raw material residue and perform the second decoction at 100°C for 20 minutes, filter the raw material residue and obtain the second filtrate;

[0040] S3: combining the first filtrate and the second filtrate obtained in step S2, and concentrating the mixture to 2 / 5 of the volume of the combined filtrate;

[0041] S4: Add the same volume of millet wine to the concentrated filtrate obtained in step S3 and concentrate to 1 / 2 of the total volume.

[0042] Example 3

[0043] This embodiment provides a composition for treating male physiological disorders, which comprises the following raw materials by weight: 0.1 part of aconite root, 0.05 part of clove, 0.09 part of epimedium, 0.1 part of strychnos nux vomica, 0.1 part of Cistanche deserticola, 0.05 part of Cnidium monnieri, and 0.05 part of Gleditsia sinensis.

[0044] The preparation method comprises the following steps:

[0045] S1: Wash all raw materials with water and soak them at 40℃ for 30min for later use;

[0046] S2: Put all the raw materials in a pot, add water and heat to boiling, adjust the temperature to 80°C and perform the first decoction for 40 minutes, filter out the raw material residue and retain the first filtrate, repeat the above steps with the raw material residue and perform the second decoction at 90°C for 30 minutes, filter the raw material residue and obtain the second filtrate;

[0047] S3: combining the first filtrate and the second filtrate obtained in step S2, and concentrating the mixture to 2 / 5 of the volume of the combined filtrate;

[0048] S4: Add the same volume of kaoliang wine to the concentrated filtrate obtained in step S3 and concentrate to 1 / 2 of the total volume.

[0049] Example 4

[0050] This embodiment provides a composition for treating male physiological disorders, which comprises the following raw materials in parts by weight: 0.3 parts of aconite root, 0.4 parts of cloves, 0.2 parts of epimedium, 0.2 parts of strychnos nux vomica, 0.2 parts of Cistanche deserticola, 0.1 parts of Cnidium monnieri, and 0.4 parts of Gleditsia sinensis.

[0051] The preparation method comprises the following steps:

[0052] S1: Wash all the raw materials with water and soak them at 35°C for 30 minutes for later use; in step S1, the soaking conditions are: temperature 30-40°C, time 30-40 minutes.

[0053] S2: Put all the raw materials in a pot, add water and heat to boiling, adjust the temperature to 80°C and perform the first decoction for 40 minutes, filter out the raw material residue and retain the first filtrate, repeat the above steps with the raw material residue and perform the second decoction at 90°C for 30 minutes, filter the raw material residue and obtain the second filtrate;

[0054] S3: combining the first filtrate and the second filtrate obtained in step S2, and concentrating the mixture to 2 / 5 of the volume of the combined filtrate;

[0055] S4: Add the same volume of kaoliang wine to the concentrated filtrate obtained in step S3 and concentrate to 1 / 2 of the total volume.

[0056] Example 5

[0057] This embodiment provides a composition for treating male physiological disorders, which comprises the following raw materials in parts by weight: 0.6 parts of aconite root, 0.3 parts of cloves, 0.1 parts of epimedium, 0.3 parts of strychnos nux vomica, 0.1 parts of Cistanche deserticola, 0.1 parts of Cnidium monnieri, and 0.5 parts of Gleditsia sinensis.

[0058] The preparation method comprises the following steps:

[0059] S1: Wash all raw materials with water and soak them at 40℃ for 30min for later use;

[0060] S2: Put all the raw materials in a pot, add water and heat to boiling, adjust the temperature to 90°C and perform the first decoction for 60 minutes, filter out the raw material residue and retain the first filtrate, repeat the above steps with the raw material residue and perform the second decoction for 30 minutes at 80°C, filter the raw material residue and obtain the second filtrate;

[0061] S3: combining the first filtrate and the second filtrate obtained in step S2, and concentrating the mixture to 2 / 5 of the volume of the combined filtrate;

[0062] S4: Add the same volume of kaoliang wine to the concentrated filtrate obtained in step S3 and concentrate to 1 / 2 of the total volume.

[0063] Comparative Example 1

[0064] The present comparative example provides a composition for treating male physiological disorders, which comprises the following raw materials by weight: 15 parts of Herba Epimedii, 8 parts of Herba Epimedii, 1.1 parts of Rhizoma Anemarrhenae, 3 parts of Rhizoma Cyathulae, 18 parts of Rhizoma Polygonati, 15 parts of Rhizoma Rehmanniae Preparata, 2 parts of Rhizoma Aconitum, 15 parts of Rhizoma Dioscoreae, 1 part of Rhizoma Licorice, and 2 parts of Cinnamon Bark.

[0065] The preparation method is a conventional tablet preparation method.

[0066] Test Example 1

[0067] 1. Experimental background: 46 patients were selected, with symptoms of difficulty in erection, short duration of erection, easy weakness, and a few with low back pain; the youngest was 21 and the oldest was 54 years old, and 21 were between 25 and 35 years old.

[0068] 2. Experimental method: The composition obtained in Example 1 was applied to 46 patients. Usage method: Spread the composition on paper and stick it on specific acupuncture points, once a day, for 12 hours each time.

[0069] 3. Experimental results: According to the statistics of patients' main complaints, 1 / 3 of the patients reported that the use of 3 patches was effective; after 30 days of use, 2 / 3 of the remaining patients' symptoms had disappeared, and they were satisfied with the erection hardness and duration; after 60 days of use, the remaining symptoms had disappeared, and those aged 21-30 had obvious morning erections on the second day of use, and their morning erections were satisfactory in hardness (only 2 of them had a slight improvement in hardness, and the symptoms disappeared after taking oral Chinese medicine for kidney tonification and conditioning. One patient was 38 years old and the other was 42 years old).

[0070] It can be seen from the results that each raw material of the composition obtained in Example 1 of the present invention has its own strong efficacy and there is no conflict or contraindication between them. Therefore, mixing them together for use can not only maximize the advantages between these drugs, but also play the effect of treating impotence.

[0071] Test Example 2

[0072] 1. Experimental method: 30 patients were selected, and their symptoms included difficulty in erection, short duration of sustained erection, easy weakness, and a few patients were accompanied by backache. The 30 patients were evenly divided into 6 groups, and the compositions obtained by Examples 1-5 (patch, one patch per day) and Comparative Example 1 (oral, 2 tablets / day) were used respectively. There was no significant difference in the frequency of use and other conditions for taking Chinese medicine; the effects on the 10th, 20th and 30th days of use and other conditions (side effects) were counted respectively.

[0073] 2. Experimental results: see Table 1 below.

[0074] Table 1

[0075]

[0076]

[0077] As can be seen from the results in Table 1, each raw material of the composition obtained in Examples 1-5 of the present invention has its own strong efficacy, and there is no conflict taboo between them. Therefore, mixing them together can not only maximize the advantages between these drugs and play the effect of treating impotence, but also avoid the side effects or blocking of each other's effects, which is more conducive to the overall therapeutic effect.

[0078] Although the present invention has been described in detail above by general description and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements can be made to the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all belong to the scope of protection claimed by the present invention.

Claims

1. A method for preparing a composition for treating male physiological disorders, characterized in that: The preparation method comprises the following steps: S1: Weigh the following raw materials in the following weight ratio: 0.1-0.7 parts of aconite root, 0.05-0.5 parts of cloves, 0.09-0.3 parts of epimedium, 0.1-0.6 parts of strychnos nux vomica, 0.1-0.6 parts of cistanche deserticola, 0.05-0.5 parts of cnidium monnieri, and 0.05-0.5 parts of sapodilla; wash all the raw materials with water and soak them for later use; S2: Put all the raw materials in a pot, add water and heat to boiling, adjust the temperature and perform the first decoction, filter out the raw material residue and retain the first filtrate, repeat the above steps with the raw material residue and perform the second decoction, filter the raw material residue and obtain the second filtrate; S3: combining the first filtrate and the second filtrate obtained in step S2 and concentrating them; S4: adding pure grain wine to the concentrated filtrate obtained in step S3 and concentrating the mixture to obtain the composition.

2. The method for preparing the composition for treating male physiological disorders according to claim 1, characterized in that: In step S1, the soaking conditions are: temperature 30-40°C, time 30-40min.

3. The method for preparing the composition for treating male physiological disorders according to claim 1, characterized in that: In step S2, the conditions for the first decoction are temperature 70-90°C and time 30-60 min; the conditions for the second decoction are temperature 80-100°C and time 20-30 min.

4. The method for preparing the composition for treating male physiological disorders according to claim 1, characterized in that: In step S3, the filtrate is concentrated to 2 / 5 of the volume of the combined filtrate.

5. The method for preparing the composition for treating male physiological disorders according to claim 1, characterized in that: In step S4, the volume ratio of the pure grain wine to the concentrated filtrate is 1:

1.

6. The method for preparing the composition for treating male physiological disorders according to claim 1, characterized in that: In step S4, the volume is concentrated to 1 / 2 of the total volume of the pure grain wine and the combined filtrate.

7. The method for preparing the composition for treating male physiological disorders according to claim 1, characterized in that: In step S4, the pure grain wine is sorghum wine or millet wine.

8. A composition for treating male physiological disorders, characterized in that: The composition is prepared by the method according to any one of claims 1 to 7; the composition comprises the following raw materials by weight: 0.4 parts of aconite root, 0.3 parts of cloves, 0.1 parts of epimedium, 0.3 parts of strychnos nux vomica, 0.3 parts of Cistanche deserticola, 0.1 parts of Cnidium monnieri, and 0.2 parts of Gleditsia sinensis.

9. The composition for treating male physiological disorders according to claim 8, characterized in that: The composition is in the form of a patch, which is used to treat male physiological disorders and is applied to specific acupuncture points of the human body; The specific acupuncture points of the human body include Mingmen acupoint and Shenshu acupoint.

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