Diluent filling device and method

Abstract

The invention discloses a diluent filling device and method. Relates to the field of medical instruments, and solves the problems of high cost and diluent waste of the existing scheme. The peristaltic pump is controlled to inject the diluent, and whether the diluent injection is completed or not is judged according to the weight change before and after the diluent injection, so that the problem of adding leakage or insufficient diluent injection amount is avoided, and the diluent injection precision is improved. Due to the automatic filling process, errors caused by manual operation are reduced, and the accuracy of medical detection is improved. The device can be suitable for sample pipes with different capacities and shapes, only corresponding filling parameters need to be adjusted, the initial state of a sample does not need to be concerned, judgment is carried out according to the relative difference value before and after liquid injection, an accurate value does not need to be known, and therefore pre-filling of a pipeline is not needed, waste of diluent is avoided, and the weight sensor does not need to be calibrated regularly.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and in particular to a diluent filling device and method. Background Art

[0002] In the process of medical testing, the sample in the sample tube often needs to be diluted in a certain proportion to ensure the accuracy of the test results. Usually, automated equipment such as plunger pumps and liquid level monitoring (multiple float switches, weighing detection) are used to achieve automatic filling of diluent.

[0003] It is usually controlled by a stepper motor peristaltic pump or a plunger pump, and its control circuit and pump cost are relatively high. The filling process and filling results are generally not monitored, resulting in the inability to determine whether there is a leak, resulting in inaccurate detection results. In addition, a float switch or a weighing sensor is used up to detect whether the diluent is exhausted. This measure has requirements on the size and position of the reagent bottle, and due to the detection error of the float switch, in order to ensure successful filling, the user is usually reminded to replace it before it is exhausted, resulting in waste of diluent; the first start-up requires the pipeline to be primed first, and the filling will continue only after the pipeline is primed, which will also cause a certain amount of diluent waste.

[0004] It can be seen that how to solve the problem of high cost and waste of diluent in the existing solution is a technical problem that needs to be solved urgently by people in this field. Summary of the invention

[0005] The purpose of the present application is to provide a diluent filling device and method to solve the problem of high cost and waste of diluent in existing solutions.

[0006] In order to solve the above technical problems, the present application provides a diluent filling device, comprising:

[0007] Control unit, diluent bottle, peristaltic pump, sample container, weight sensor;

[0008] The diluent bottle is used to contain the diluent; the interior of the diluent bottle is connected to the inlet of the peristaltic pump via a liquid pipeline, the outlet of the peristaltic pump is connected to the filling port, and the control unit is connected to the peristaltic pump;

[0009] The sample container is arranged directly below the filling port; the weight sensor is arranged directly below the sample container to obtain the weight value of the sample container and send it to the control unit;

[0010] The control unit determines the initial injection time according to the target injection volume, controls the peristaltic pump to operate according to the initial injection time, determines whether the injection is completed according to the change in the weight value before and after the injection, and controls the peristaltic pump to perform additional injection work according to the additional injection time when the injection is not completed.

[0011] As an optional solution, in the above diluent filling device, the sample container includes a sample rack and a plurality of sample tubes; and further includes: a stepping motor pusher structure;

[0012] The sample tube is placed in the sample rack; the control unit controls the stepper motor pusher structure to push the sample rack to move on the sample rack platform;

[0013] The control unit is used to control the stepper motor pusher structure to empty the sample rack on the sample rack platform after receiving a filling task; the control unit is also used to control the stepper motor pusher structure to push the sample rack after the current sample tube is filled with liquid, so that the next sample tube is directly below the filling port.

[0014] As an optional solution, the above diluent filling device further comprises: a bottle detection sensor; the bottle detection sensor is used to collect the presence signal of the diluent bottle and send it to the control unit;

[0015] The control unit is used for obtaining the presence signal sent by the bottle detection sensor after receiving the filling task, and issuing a prompt message for loading the diluent bottle if the presence signal indicates that the diluent bottle is not loaded.

[0016] As an optional solution, in the above diluent filling device, the control unit includes: an industrial control board, a drive board, a sensor detection circuit board, and a single-channel weighing acquisition board;

[0017] The driving board is connected to the peristaltic pump and the stepper motor pusher structure, and the industrial control board is used to output a driving signal and a movement control signal to the driving board. The driving board controls the peristaltic pump to work and controls the stepper motor pusher structure to push the sample rack;

[0018] The single-channel weighing acquisition board is used to collect the weight value sent by the weight sensor in real time, and send the signal to the industrial control board after signal processing; the industrial control board controls the start, stop and replenishment operation of the peristaltic pump according to the change of the weight value and the preset filling parameters;

[0019] The sensor detection circuit board is used to detect the in-place signal of the bottle detection sensor and feed back the detection result to the industrial control board; the industrial control board determines whether the diluent bottle is correctly loaded according to the in-place signal, and issues corresponding prompt information or control instructions accordingly.

[0020] In order to solve the above technical problems, the present application also provides a diluent filling method, which is applied to a diluent filling device, comprising: a control unit, a diluent bottle, a peristaltic pump, a sample container, and a weight sensor; the diluent bottle is used to contain the diluent; the interior of the diluent bottle is connected to the inlet of the peristaltic pump through a liquid pipeline, the outlet of the peristaltic pump is connected to the filling port, and the control unit is connected to the peristaltic pump; the sample container is arranged directly below the filling port; the weight sensor is arranged directly below the sample container, and obtains the weight value of the sample container and sends it to the control unit; the method comprises:

[0021] receiving the target injection volume;

[0022] Determining the initial injection time according to the target injection volume;

[0023] Controlling the peristaltic pump to perform injection work according to the initial injection time;

[0024] Obtain the weight values ​​before and after the injection sent by the weight sensor to obtain the actual injection weight;

[0025] Determining whether the filling is completed according to the actual filling weight and the target filling amount;

[0026] If not, the replenishing liquid injection time is determined according to the actual added weight and the target injection amount, and the peristaltic pump is controlled to perform replenishing work according to the replenishing liquid injection time.

[0027] As an optional solution, in the above diluent filling method, determining the initial injection time according to the target injection volume includes:

[0028] Get the flow rate of the peristaltic pump;

[0029] The initial injection time is obtained according to the ratio of the target injection volume to the flow rate of the peristaltic pump.

[0030] As an optional solution, in the above diluent filling method, the step of obtaining the weight values ​​before and after the filling sent by the weight sensor to obtain the actual added weight includes:

[0031] Get the weight sensor coefficient;

[0032] receiving a first weight value sent by the weight sensor before liquid injection;

[0033] receiving a second weight value sent by the weight sensor after liquid injection;

[0034] Obtaining an actual added weight according to the first weight value, the second weight value and a first formula;

[0035] The first formula is: M=AD2*K-AD1*K;

[0036] Wherein, M is the actual added weight; AD1 is the first weight value; AD2 is the second weight value; and K is the weight sensor coefficient.

[0037] As an optional solution, in the above diluent filling method, judging whether the filling is completed according to the actual filling weight and the target filling amount includes:

[0038] Determining whether the actual injection amount is less than the target injection amount;

[0039] If not, it is determined that the diluent filling is complete;

[0040] If yes, it is determined that the diluent has not been filled completely.

[0041] As an optional solution, in the above diluent filling method, the filling time is determined according to the actual filling weight and the target filling amount, and the peristaltic pump is controlled to perform the filling work according to the filling time, including:

[0042] Obtaining a target additional amount according to the difference between the actual additional amount and the target injection amount;

[0043] Obtaining a replenishment time according to a ratio of the target replenishment amount to the flow rate of the peristaltic pump;

[0044] Controlling the peristaltic pump to perform replenishment work and obtaining the actual replenishment amount in real time;

[0045] Determining whether the actual added amount reaches the target injection amount within twice the added injection time;

[0046] If yes, it is determined that the diluent addition is complete;

[0047] If not, it is determined that the diluent addition is not complete.

[0048] As an optional solution, in the above diluent adding method, after determining that the diluent has not been added completely, the method further includes:

[0049] Turn off the peristaltic pump;

[0050] A reminder message is issued to replace the diluent bottle.

[0051] The diluent filling device provided by the present application includes: a control unit, a diluent bottle, a peristaltic pump, a sample container, and a weight sensor; the diluent bottle is used to contain the diluent; the interior of the diluent bottle is connected to the inlet of the peristaltic pump through a liquid pipeline, the outlet of the peristaltic pump is connected to the filling port, and the control unit is connected to the peristaltic pump; the sample container is arranged directly below the filling port; the weight sensor is arranged directly below the sample container, obtains the weight value of the sample container and sends it to the control unit; the control unit determines the initial filling time according to the target filling amount, controls the peristaltic pump to work according to the initial filling time, determines whether the filling is completed according to the change of the weight value before and after the filling, and controls the peristaltic pump to perform the additional filling work according to the additional filling time when the filling is not completed. By controlling the peristaltic pump to fill the diluent, and judging whether the filling is completed according to the weight change before and after the filling, the problem of missing or insufficient filling is avoided, and the accuracy of the diluent filling is improved. The automated filling process reduces the errors of human operation and improves the accuracy of medical testing. It can be applied to sample tubes of different capacities and shapes. It only needs to adjust the corresponding filling parameters without paying attention to the initial state of the sample. Since the judgment is made based on the relative difference before and after the injection, there is no need to know the exact value. Therefore, the pipeline does not need to be pre-filled, avoiding the waste of diluent and the need to calibrate the weight sensor regularly.

[0052] In addition, the present application also provides a diluent filling method, which corresponds to the above-mentioned diluent filling device and has the same effect as above. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] In order to more clearly illustrate the embodiments of the present application, the following is a brief introduction to the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0054] Figure 1 A schematic diagram of a diluent filling device is provided for this embodiment;

[0055] Figure 2 A schematic diagram of a filling pipeline connection is provided for this embodiment;

[0056] Figure 3 A flow chart of a diluent filling method provided in an embodiment of the present application. DETAILED DESCRIPTION

[0057] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0058] The core of this application is to provide a diluent filling device and method.

[0059] In order to enable those skilled in the art to better understand the present application, the present application is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0060] During medical testing, samples in sample tubes often need to be diluted in a certain proportion to ensure the accuracy of the test results. The traditional manual dilution method has the following problems: Low precision: Manual operation is difficult to ensure the accuracy of dilution, resulting in possible errors in the test results. Cumbersome operation: The manual dilution process requires manual measurement and mixing, which is time-consuming and prone to errors. Easy to contaminate: Manual operation increases the chance of sample contact with the external environment, increasing the risk of cross contamination.

[0061] Automated equipment, such as plunger pumps and liquid level monitoring (multiple float switches, weighing detection), are usually used to achieve automatic filling of diluent. These solutions use float switches or weighing sensors to detect whether the diluent is exhausted, but have requirements for the size and position of the reagent bottle: the design and use of the equipment are limited by the size of the container and the placement. Float switch detection error: The float switch may cause inaccurate detection due to errors, thereby affecting the accuracy of filling. Waste of diluent: To ensure successful filling, the system usually reminds the user to replace the diluent before it runs out, which may result in waste of diluent. Pipeline perfusion requirements: The pipeline needs to be primed when the equipment is started for the first time, which will also cause waste of diluent. This application does not limit its application field, experimental environment, etc., and this solution is applicable to any environment where diluent filling is required.

[0062] To solve the above problems, this embodiment provides a diluent filling device, such as Figure 1 As shown, including:

[0063] Control unit 11, diluent bottle 12, peristaltic pump 13, sample container 14, weight sensor 15;

[0064] The diluent bottle 12 is used to contain the diluent; the interior of the diluent bottle 12 is connected to the inlet of the peristaltic pump 13 via a liquid pipeline, the outlet of the peristaltic pump 13 is connected to the filling port, and the control unit 11 is connected to the peristaltic pump 13;

[0065] The sample container 14 is disposed directly below the filling port; the weight sensor 15 is disposed directly below the sample container 14 to obtain the weight value of the sample container 14 and send it to the control unit 11;

[0066] The control unit 11 determines the initial injection time according to the target injection volume, controls the peristaltic pump 13 to work according to the initial injection time, determines whether the injection is completed according to the change in weight value before and after the injection, and controls the peristaltic pump 13 to perform additional injection work according to the additional injection time when the injection is not completed.

[0067] In the present application, the diluent filling device is a high-precision automated system used for filling diluent of samples in the field of medical testing.

[0068] In this embodiment, the control unit 11 can be specifically an integrated circuit system, which is responsible for receiving and processing signals from the weight sensor 15, controlling the start and stop of the peristaltic pump 13, and executing the replenishment logic. This embodiment does not limit its specific structure, and it can be set according to actual needs.

[0069] The diluent bottle 12 is a container for storing the diluent, which can be specifically a sealed bottle, connected to the peristaltic pump 13 through a liquid pipeline to ensure the cleanliness and safe storage of the diluent. The present embodiment does not limit its size, shape, material, etc. The liquid pipeline connects the diluent bottle 12 and the peristaltic pump 13, which can be specifically a food-grade or medical-grade hose to ensure that the diluent is not contaminated during the transmission process.

[0070] The peristaltic pump 13 is a pump for accurately conveying liquids. It moves liquids by squeezing a hose. It can be specifically a precision pump driven by a brushless motor. It is used to extract diluent from the diluent bottle 12 and fill it through the sample container 14.

[0071] The sample container 14 is a device for storing sample tubes, which can be specifically a rack with multiple sample tube slots, located just below the filling port, for receiving the diluent added by the peristaltic pump 13. It can also be a reagent bottle that needs to be filled with diluent, which can be selected according to actual needs. The filling port refers to the connection between the outlet of the peristaltic pump 13 and the sample container 14, which can be specifically a nozzle or pipe end designed to accurately control the flow direction and amount of the diluent.

[0072] The weight sensor 15 is a sensor for measuring the weight change of the sample container 14 , and may specifically be a high-precision weighing sensor for monitoring the weight change of the sample container 14 in real time and sending the data to the control unit 11 .

[0073] The initial filling time refers to the basic filling time calculated based on the target filling volume. If the filling target is not reached, additional filling is required. The additional filling time refers to the additional filling time calculated by the control unit 11 when the initial filling fails to reach the target filling volume, which is used to ensure that the amount of diluent in the sample container 14 reaches the preset target.

[0074] The control unit 11 controls the operation of the peristaltic pump 13 to achieve precise control of the amount of diluent in the sample container 14. The weight sensor 15 monitors the weight change of the sample container 14 in real time to ensure the accuracy and reliability of the filling process. When the filling amount does not reach the target, the control unit 11 automatically calculates the filling time and amount to achieve the filling operation and ensure the integrity of the filling.

[0075] The diluent filling device provided by this embodiment includes: a control unit 11, a diluent bottle 12, a peristaltic pump 13, a sample container 14, and a weight sensor 15; the diluent bottle 12 is used to contain the diluent; the interior of the diluent bottle 12 is connected to the inlet of the peristaltic pump 13 through a liquid pipeline, the outlet of the peristaltic pump 13 is connected to the filling port, and the control unit 11 is connected to the peristaltic pump 13; the sample container 14 is arranged directly below the filling port; the weight sensor 15 is arranged directly below the sample container 14, obtains the weight value of the sample container 14 and sends it to the control unit 11; the control unit 11 determines the initial filling time according to the target filling amount, controls the peristaltic pump 13 to work according to the initial filling time, determines whether the filling is completed according to the change of the weight value before and after the filling, and controls the peristaltic pump 13 to perform the supplementary filling work according to the supplementary filling time when the filling is not completed. By controlling the peristaltic pump 13 to fill the diluent, and judging whether the filling is completed according to the weight change before and after the filling, the problem of missing or insufficient filling is avoided, and the accuracy of diluent filling is improved. The automated filling process reduces human error and improves the accuracy of medical testing. It can be applied to sample tubes of different capacities and shapes. It only needs to adjust the corresponding filling parameters without paying attention to the initial state of the sample. Since the judgment is based on the relative difference before and after the injection, there is no need to know the exact value. Therefore, the pipeline does not need to be pre-filled, avoiding the waste of diluent and the need to calibrate the weight sensor regularly15.

[0076] According to the above embodiment, in a specific implementation, the sample container 14 includes a sample rack, a plurality of sample tubes; and further includes: a stepper motor pusher structure 16;

[0077] The sample tube is placed in the sample rack; the control unit 11 controls the stepper motor pusher structure 16 to push the sample rack to move on the sample rack platform;

[0078] The control unit 11 is used to control the stepper motor pusher structure 16 to empty the sample rack on the sample rack platform after receiving the filling task; the control unit 11 is also used to control the stepper motor pusher structure 16 to push the sample rack after the current sample tube is filled with liquid, so that the next sample tube is directly below the filling port.

[0079] A sample rack is a structure that holds multiple sample tubes. It usually has multiple slots or wells, with each sample tube placed in a separate slot to ensure stability and accurate alignment during the filling process. Sample tubes are used to store samples to be tested, and they are placed in the slots of the sample rack. Sample tubes can be designed with standard sizes to facilitate automation and uniform processing.

[0080] The stepper motor pusher structure 16 is a mechanical device driven by a stepper motor, which is used to push the sample rack to move along a predetermined path on the sample rack platform. The stepper motor can ensure that the sample rack moves to the exact filling position due to its precise control characteristics. The sample rack platform refers to a platform that supports the sample rack and allows it to move on it. The design of the platform is usually matched with the stepper motor pusher structure 16 to achieve accurate sample tube positioning.

[0081] After receiving the filling task, the control unit 11 will issue an instruction to the stepper motor pusher structure 16 to empty the sample rack on the sample rack platform to ensure that the filling process starts from an empty sample rack. The filling task refers to the instruction received by the control unit 11, which is used to start the entire filling process. This may include parameters such as the filling order and filling amount of the sample tubes. Under the control of the control unit 11, after the peristaltic pump 13 completes the filling of the current sample tube, the control unit 11 will monitor the data of the weight sensor 15 to determine whether the preset filling amount has been reached. After the current sample tube is filled, the control unit 11 again issues an instruction to the stepper motor pusher structure 16 to push the sample rack so that the next sample tube moves to the bottom of the filling port, ready to receive the diluent.

[0082] Through the precise control of the stepper motor pusher structure 16, the automatic positioning and sequential filling of the sample tubes are realized, which improves the efficiency and accuracy of the filling process. The stepper motor pusher structure 16 is controlled to empty and reposition the sample rack, so that the device can adapt to different filling tasks and sample quantities. The sample rack platform and the stepper motor pusher structure 16 work together to ensure that each sample tube can be accurately positioned under the filling port to achieve accurate filling.

[0083] Automated sample rack movement reduces manual operations and improves the overall efficiency of the filling process. Sample tube positioning reduces human error and ensures accurate sample filling. Adapts to different numbers and arrangements of sample tubes, increasing the applicability of the device. Efficient and accurate diluent filling is achieved, suitable for medical testing environments that require large sample processing.

[0084] According to the above embodiment, in a specific implementation scheme, it further includes: a bottle detection sensor 17; the bottle detection sensor 17 is used to collect the presence signal of the diluent bottle 12 and send it to the control unit 11;

[0085] The control unit 11 is used to obtain the presence signal sent by the bottle detection sensor 17 after receiving the filling task, and issue a prompt message to load the diluent bottle 12 if the presence signal indicates that the diluent bottle 12 is not loaded.

[0086] In this embodiment, the introduction of the bottle detection sensor 17 adds a layer of intelligent monitoring function to the diluent filling device to ensure the accuracy and safety of the operation.

[0087] The bottle detection sensor 17 is a sensor for detecting whether the diluent bottle 12 has been correctly placed in the predetermined position. It can be specifically a photoelectric sensor, a proximity sensor or other types of sensors, which can send a signal to indicate the presence or absence of the diluent bottle 12. The presence signal is a signal sent by the bottle detection sensor 17 after detecting that the diluent bottle 12 is correctly placed. This signal can be a signal of level change, frequency change or other forms to indicate the status of the diluent bottle 12.

[0088] After receiving the filling task, the control unit 11 not only controls the movement of the peristaltic pump 13 and the sample rack, but also acquires and processes the in-place signal from the bottle detection sensor 17. The control unit 11 can be specifically a microcontroller or computer system with an input / output interface.

[0089] When the control unit 11 detects that the diluent bottle 12 is not loaded correctly, it will issue a loading prompt message. This prompt can be visual (such as a flashing indicator light), auditory (such as a buzzer sound) or digital (such as a text message on the display screen) to remind the operator to perform necessary operations.

[0090] Through real-time monitoring by the bottle detection sensor 17, the control unit 11 can ensure that the diluent bottle 12 is correctly loaded, thereby avoiding filling failure due to lack of diluent. Before starting to fill, the control unit 11 prevents possible errors by checking the in-place signal to ensure the smooth progress of the filling process. When it is detected that the diluent bottle 12 is not loaded, the prompt information issued by the control unit 11 provides a clear interactive signal for the user to guide the user to perform the correct operation.

[0091] According to the above embodiment, in a specific implementation scheme, the control unit 11 includes: an industrial control board, a driver board, a sensor detection circuit board, and a single-channel weighing acquisition board;

[0092] The driving board is connected to the peristaltic pump 13 and the stepper motor pusher structure 16. The industrial control board is used to output a driving signal and a movement control signal to the driving board. The driving board controls the peristaltic pump 13 to work and controls the stepper motor pusher structure 16 to push the sample rack.

[0093] The single-channel weighing acquisition board is used to collect the weight value sent by the weight sensor 15 in real time, and send it to the industrial control board after signal processing; the industrial control board controls the start, stop and replenishment operation of the peristaltic pump 13 according to the change of the weight value and the preset filling parameters;

[0094] The sensor detection circuit board is used to detect the in-place signal of the bottle detection sensor 17 and feed back the detection result to the industrial control board; the industrial control board determines whether the diluent bottle 12 is correctly loaded according to the in-place signal and issues corresponding prompt information or control instructions accordingly.

[0095] The industrial control board, as the core of the entire control unit 11, is responsible for coordinating and processing all information from sensors and user inputs, and outputting control instructions to other components. Specifically, it is a high-performance industrial control computer board.

[0096] The driving board connects and controls the peristaltic pump 13 and the stepper motor pusher structure 16. The driving board receives the instructions from the industrial control board and converts the electrical signals into the form required to control the peristaltic pump 13 and the stepper motor to ensure accurate filling and movement of the sample rack.

[0097] The sensor detection circuit board is used to detect the in-position signal of the bottle detection sensor 17 and feed back the detection result to the industrial control board. It is responsible for processing the signals from the bottle detection sensor 17 and ensuring that these signals are accurately transmitted to the industrial control board.

[0098] The single-channel weighing acquisition board is responsible for real-time acquisition of the weight value sent by the weight sensor 15, and sends it to the industrial control board after necessary signal processing. This board ensures the accuracy and real-time performance of the weight data and provides the industrial control board with key information required for filling control.

[0099] The industrial control board accurately controls the start, stop and replenishment of the peristaltic pump 13 to ensure accurate filling of the diluent. The single-channel weighing acquisition board monitors the weight change of the sample container 14 in real time and provides accurate data support for the industrial control board. The sensor detection circuit board intelligently detects the in-place status of the diluent bottle 12 to improve the reliability of the system and the user's operating convenience.

[0100] The present application also provides a diluent filling method, which is applied to a diluent filling device, comprising: a control unit 11, a diluent bottle 12, a peristaltic pump 13, a sample container 14, and a weight sensor 15; the diluent bottle 12 is used to contain the diluent; the interior of the diluent bottle 12 is connected to the inlet of the peristaltic pump 13 through a liquid pipeline, the outlet of the peristaltic pump 13 is connected to the filling port, and the control unit 11 is connected to the peristaltic pump 13; the sample container 14 is arranged directly below the filling port; the weight sensor 15 is arranged directly below the sample container 14, and obtains the weight value of the sample container 14 and sends it to the control unit 11; the method comprises:

[0101] S11: receiving the target injection volume;

[0102] S12: determining the initial injection time according to the target injection volume;

[0103] S13: Control the peristaltic pump to perform injection work according to the initial injection time;

[0104] S14: Obtain the weight values ​​before and after the injection sent by the weight sensor to obtain the actual injection weight;

[0105] S15: judging whether the filling is completed according to the actual filling weight and the target filling amount;

[0106] S16: If not, the replenishing liquid injection time is determined according to the actual added weight and the target injection amount, and the peristaltic pump 13 is controlled to perform replenishing work according to the replenishing liquid injection time.

[0107] In this embodiment, the target injection volume received in step S11 refers to the volume of diluent required for each sample set by the user. The amount of diluent to be injected is determined to provide a basis for subsequent injection operations. Specifically, it is input through the user interface or set by a preset program.

[0108] The initial injection time is determined according to the target injection volume, and can be calculated according to the flow rate of the peristaltic pump 13 and the target injection volume, or can be determined according to a preset time comparison table.

[0109] The peristaltic pump 13 is controlled to perform the injection work according to the initial injection time. The peristaltic pump 13 operates within the set time according to the control signal to transport the diluent from the diluent bottle 12 to the sample container 14, thereby achieving accurate transportation of the diluent.

[0110] The weight values ​​before and after the injection sent by the weight sensor 15 are obtained to obtain the actual injection weight, and the actual amount of liquid injected is determined according to the weight change of the sample container 14 before and after the injection measured by the weight sensor 15. Whether the injection is completed is determined according to the actual injection weight and the target injection amount to ensure that each sample obtains the correct amount of diluent. If yes, the injection work is finished.

[0111] If not, the replenishing time is determined according to the actual added weight and the target injection volume, and the peristaltic pump 13 is controlled to perform the replenishing work according to the replenishing time. The additional filling time is calculated according to the difference between the actual filling volume and the target injection volume to replenish the insufficient diluent to ensure that the filling volume reaches the target.

[0112] The diluent filling method provided in this embodiment controls the peristaltic pump 13 to fill the diluent, and determines whether the filling is completed according to the weight change before and after the filling, thereby avoiding the problem of missing or insufficient filling, and improving the accuracy of diluent filling. The automated filling process reduces human operation errors and improves the accuracy of medical testing. It can be applied to sample tubes of different capacities and shapes, and only the corresponding filling parameters need to be adjusted, without paying attention to the initial state of the sample. Since the judgment is based on the relative difference before and after the filling, there is no need to know the exact value, so the pipeline does not need to be pre-filled, avoiding the waste of diluent, and there is no need to calibrate the weight sensor 15 regularly.

[0113] According to the above embodiment, the process of determining the initial injection time is a key step in the diluent injection method, which ensures the accuracy of the injection operation. In a specific embodiment, determining the initial injection time according to the target injection volume includes:

[0114] Obtain the flow rate of the peristaltic pump 13;

[0115] The initial injection time is obtained according to the ratio of the target injection volume to the flow rate of the peristaltic pump 13 .

[0116] The target injection volume refers to the volume of diluent required for each sample set by the user. The flow rate of the peristaltic pump 13 refers to the volume of liquid that the peristaltic pump 13 can deliver per unit time, usually expressed in milliliters per minute (mL / min) or liters per hour (L / h). The initial injection time is calculated based on the flow rate of the peristaltic pump 13 and the target injection volume, and is used to control the working time of the peristaltic pump 13 during the injection process.

[0117] Usually, the flow rate of the peristaltic pump 13 is written into the industrial control system during factory testing. In order to improve the test accuracy, the flow rate of the peristaltic pump 13 can be obtained through pre-calibration and testing, and the parameter is stored in the control unit 11.

[0118] By accurately calculating the working time of the peristaltic pump 13, accurate delivery of the diluent is ensured, avoiding the problem of over- or under-dosage. The peristaltic pump 13 can be adjusted according to different flow rates and target injection volumes to adapt to different application scenarios.

[0119] According to the above embodiment, the process of obtaining the actual added weight is a key step to ensure the accuracy of diluent filling. In a specific implementation scheme, the weight values ​​before and after the injection sent by the weight sensor 15 are obtained to obtain the actual added weight, including:

[0120] Get the weight sensor 15 coefficient;

[0121] Receiving a first weight value sent by the weight sensor 15 before liquid injection;

[0122] Receiving a second weight value sent by the weight sensor 15 after the injection;

[0123] Obtaining the actual added weight according to the first weight value, the second weight value and the first formula;

[0124] The first formula is: M=AD2*K-AD1*K;

[0125] Among them, M is the actual added weight; AD1 is the first weight value; AD2 is the second weight value; K is the coefficient of weight sensor 15.

[0126] The weight sensor 15 coefficient (K) refers to the calibration coefficient of the weight sensor 15, which is used to convert the original reading of the sensor into the actual weight value. Usually, it has been written into the industrial control system during factory testing. The weight sensor 15 coefficient can be obtained through a pre-calibration process and stored in the control unit 11.

[0127] The first weight value (AD1) refers to the weight value of the sample container 14 measured by the weight sensor 15 before the filling begins. Before the filling, the control unit 11 sends a request signal to the weight sensor 15, and receives and records the reading of the weight sensor 15.

[0128] The second weight value (AD2) refers to the weight value of the sample container 14 measured by the weight sensor 15 after the filling is completed. After the filling is completed, the control unit 11 sends a request signal to the weight sensor 15 again, and receives and records the reading of the weight sensor 15.

[0129] The actual filling weight (M) is the actual filling amount of the diluent obtained by calculation. The control unit 11 uses the first formula to combine the first weight value, the second weight value and the coefficient of the weight sensor 15 to calculate the actual filling amount.

[0130] The weight of the sample container 14 before and after filling is accurately measured by the weight sensor 15, thereby ensuring the accuracy of the filling amount, reducing human intervention, and improving the efficiency and accuracy of the operation.

[0131] According to the above embodiment, in a specific implementation scheme, judging whether the filling is completed according to the actual filling weight and the target filling amount includes:

[0132] Determine whether the actual injection amount is less than the target injection amount;

[0133] If not, it is determined that the diluent filling is complete;

[0134] If yes, it is determined that the diluent has not been filled completely.

[0135] It is determined whether the actual added weight is less than the target injection volume to determine whether additional addition operations are required. If not, it is determined that the diluent injection is completed, confirming that the injection process has reached or exceeded the predetermined target, and no further operation is required. If the actual added weight is greater than or equal to the target injection volume, the control unit 11 records the state of filling completion.

[0136] If yes, it is determined that the diluent has not been filled, and the situation that additional filling operation is required is identified to ensure that the sample obtains enough diluent. If the actual added weight is less than the target injection volume, the control unit 11 starts the replenishment logic, calculates the replenishment time, and controls the peristaltic pump 13 to perform the replenishment work.

[0137] Through precise judgment logic, it ensures that each sample receives the correct amount of diluent, which reduces human operation errors and improves the accuracy and reliability of filling.

[0138] According to the above embodiment, the replenishment work is a key step to ensure that the diluent filling amount reaches the target requirement. In a specific implementation scheme, the replenishment time is determined according to the actual added weight and the target injection amount, and the peristaltic pump 13 is controlled to perform the replenishment work according to the replenishment time, including:

[0139] The target additional amount is obtained according to the difference between the actual added amount and the target injection amount;

[0140] The replenishment time is obtained according to the ratio of the target replenishment amount to the flow rate of the peristaltic pump 13;

[0141] Control the peristaltic pump 13 to perform replenishment work and obtain the actual replenishment amount in real time;

[0142] Determine whether the actual amount of liquid added reaches the target amount of liquid added within twice the time of the liquid addition;

[0143] If yes, it is determined that the diluent addition is complete;

[0144] If not, it is determined that the diluent addition is not complete.

[0145] The target additional amount is obtained based on the difference between the actual added weight and the target injection amount, that is, the amount of diluent that needs to be additionally added to ensure that the target injection amount is reached. The additional injection time is obtained based on the ratio of the target additional amount to the flow rate of the peristaltic pump 13, and the additional time that the peristaltic pump 13 needs to work is determined to add the remaining diluent. The additional injection time = target additional amount / flow rate of the peristaltic pump 13.

[0146] Perform the replenishment operation and monitor the actual replenishment amount during the replenishment process, that is, the real-time filling amount. Determine whether the actual replenishment amount reaches the target filling amount within twice the replenishment filling time. If so, it is determined that the diluent replenishment is completed, which may be due to the diluent being exhausted or bubbles in the filling process, resulting in the initial filling being incomplete. If not, it is determined that the diluent replenishment is not completed, which may be due to the diluent being used up.

[0147] Specifically, after determining that the diluent has not been added, the method further includes:

[0148] Turn off the peristaltic pump 13;

[0149] A reminder message for replacing the diluent bottle 12 is issued.

[0150] Further replenishment operation is stopped to prevent overfilling or idling of the equipment. The control unit 11 sends a shutdown signal to the peristaltic pump 13 to interrupt the operation of the peristaltic pump 13.

[0151] A prompt message for replacing the diluent bottle 12 is sent to inform the operator that the diluent may have been exhausted or there is a problem, and the diluent bottle 12 needs to be replaced to continue the operation. The control unit 11 sends a prompt message for replacing the diluent bottle 12 through a user interface (such as a display screen, indicator light or sound prompt).

[0152] By shutting down the peristaltic pump 13 in time, overfilling caused by idling of the equipment or erroneous operation is avoided. Timely user prompt information allows the operator to respond quickly, reducing equipment downtime and improving overall operation efficiency.

[0153] The above is a detailed introduction to the diluent filling device and method provided by the present application. The various embodiments in the specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same and similar parts between the embodiments can be referenced to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part description. It should be pointed out that for ordinary technicians in this technical field, without departing from the principles of the present application, several improvements and modifications can be made to the present application, and these improvements and modifications also fall within the scope of protection of the claims of the present application.

[0154] It should also be noted that, in this specification, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "comprise", "include" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the statement "comprises a ..." does not exclude the presence of other identical elements in the process, method, article or device including the element.

Claims

1. A diluent filling device, characterized in that: include: Control unit, diluent bottle, peristaltic pump, sample container, weight sensor; The diluent bottle is used to contain the diluent; the interior of the diluent bottle is connected to the inlet of the peristaltic pump via a liquid pipeline, the outlet of the peristaltic pump is connected to the filling port, and the control unit is connected to the peristaltic pump; The sample container is arranged directly below the filling port; the weight sensor is arranged directly below the sample container to obtain the weight value of the sample container and send it to the control unit; The control unit determines the initial injection time according to the target injection volume, controls the peristaltic pump to operate according to the initial injection time, determines whether the injection is completed according to the change in the weight value before and after the injection, and controls the peristaltic pump to perform additional injection work according to the additional injection time when the injection is not completed.

2. The diluent filling device according to claim 1, characterized in that: The sample container includes a sample rack and a plurality of sample tubes; and also includes: a stepper motor pusher structure; The sample tube is placed in the sample rack; the control unit controls the stepper motor pusher structure to push the sample rack to move on the sample rack platform; The control unit is used to control the stepper motor pusher structure to empty the sample rack on the sample rack platform after receiving a filling task; the control unit is also used to control the stepper motor pusher structure to push the sample rack after the current sample tube is filled with liquid, so that the next sample tube is directly below the filling port.

3. The diluent filling device according to claim 2, characterized in that: Also includes: Bottle detection sensor; the bottle detection sensor is used to collect the presence signal of the diluent bottle and send it to the control unit; The control unit is used for obtaining the presence signal sent by the bottle detection sensor after receiving the filling task, and issuing a prompt message for loading the diluent bottle if the presence signal indicates that the diluent bottle is not loaded.

4. The diluent filling device according to claim 3, characterized in that: The control unit includes: an industrial control board, a drive board, a sensor detection circuit board, and a single-channel weighing acquisition board; The driving board is connected to the peristaltic pump and the stepper motor pusher structure, and the industrial control board is used to output a driving signal and a movement control signal to the driving board. The driving board controls the peristaltic pump to work and controls the stepper motor pusher structure to push the sample rack; The single-channel weighing acquisition board is used to collect the weight value sent by the weight sensor in real time, and send the signal to the industrial control board after signal processing; the industrial control board controls the start, stop and replenishment operation of the peristaltic pump according to the change of the weight value and the preset filling parameters; The sensor detection circuit board is used to detect the in-place signal of the bottle detection sensor and feed back the detection result to the industrial control board; the industrial control board determines whether the diluent bottle is correctly loaded according to the in-place signal, and issues corresponding prompt information or control instructions accordingly.

5. A diluent filling method, characterized in that: The invention is applied to a diluent filling device, comprising: a control unit, a diluent bottle, a peristaltic pump, a sample container, and a weight sensor; the diluent bottle is used to contain the diluent; the interior of the diluent bottle is connected to the inlet of the peristaltic pump through a liquid pipeline, the outlet of the peristaltic pump is connected to the filling port, and the control unit is connected to the peristaltic pump; the sample container is arranged directly below the filling port; the weight sensor is arranged directly below the sample container, and the weight value of the sample container is obtained and sent to the control unit; the method comprises: receiving the target injection volume; Determining the initial injection time according to the target injection volume; Controlling the peristaltic pump to perform injection work according to the initial injection time; Obtain the weight values ​​before and after the injection sent by the weight sensor to obtain the actual injection weight; Determining whether the filling is completed according to the actual filling weight and the target filling amount; If not, the replenishing liquid injection time is determined according to the actual added weight and the target injection amount, and the peristaltic pump is controlled to perform replenishing work according to the replenishing liquid injection time.

6. The diluent filling method according to claim 5, characterized in that: Determining the initial injection time according to the target injection volume includes: Get the flow rate of the peristaltic pump; The initial injection time is obtained according to the ratio of the target injection volume to the flow rate of the peristaltic pump.

7. The diluent filling method according to claim 6, characterized in that: The step of obtaining the weight values ​​before and after the injection sent by the weight sensor to obtain the actual injection weight includes: Get the weight sensor coefficient; receiving a first weight value sent by the weight sensor before liquid injection; receiving a second weight value sent by the weight sensor after liquid injection; Obtaining an actual added weight according to the first weight value, the second weight value and a first formula; The first formula is: M=AD2*K-AD1*K; Wherein, M is the actual added weight; AD1 is the first weight value; AD2 is the second weight value; and K is the weight sensor coefficient.

8. The diluent filling method according to claim 7, characterized in that: The determining whether the filling is completed according to the actual filling weight and the target filling amount includes: Determining whether the actual injection amount is less than the target injection amount; If not, it is determined that the diluent filling is complete; If yes, it is determined that the diluent has not been filled completely.

9. The diluent filling method according to claim 8, characterized in that: The method of determining the replenishing liquid injection time according to the actual added liquid weight and the target liquid injection amount, and controlling the peristaltic pump to perform replenishing work according to the replenishing liquid injection time includes: Obtaining a target additional amount according to the difference between the actual additional amount and the target injection amount; Obtaining a replenishment time according to a ratio of the target replenishment amount to the flow rate of the peristaltic pump; Controlling the peristaltic pump to perform replenishment work and obtaining the actual replenishment amount in real time; Determining whether the actual added amount reaches the target injection amount within twice the added injection time; If yes, it is determined that the diluent addition is complete; If not, it is determined that the diluent addition is not complete.

10. The diluent filling method according to claim 9, characterized in that: After determining that the diluent has not been added, the method further includes: Turn off the peristaltic pump; A reminder message is issued to replace the diluent bottle.

Images