Quantitative uniform mixing system

Abstract

The invention relates to the technical field of biological pharmacy, in particular to a quantitative uniform mixing system. The quantitative uniform mixing system comprises a stock solution container, a liquid conveying pipeline, a conveying pump, a uniform mixing container, a stirring device, a weighing device and a control device; the conveying pump, the stirring device and the weighing device are electrically connected with the control device; an inlet of the liquid conveying pipeline is connected with the stock solution container, an outlet of the liquid conveying pipeline is connected with the uniform mixing container, and the conveying pump is arranged on the liquid conveying pipeline; stirring blades of the stirring device are arranged in the blending container, and the weighing device is arranged at the bottom of the blending container to measure the weight of the mixed liquid medicine in real time. Therefore, manual operation during liquid preparation can be reduced, meanwhile, the liquid preparation efficiency is improved, and the liquid preparation accuracy is also ensured.

Description

Technical Field

[0001] The invention relates to the technical field of biopharmaceuticals, and in particular to a quantitative mixing system. Background Art

[0002] At present, when preparing stock solutions in the field of biopharmaceuticals, the method of manually transporting and weighing the liquid is usually adopted. In this process, there are:

[0003] 1) The subjective consciousness of personnel leads to poor consistency in each liquid preparation process;

[0004] 2) Manual operation is inefficient;

[0005] 3) Liquid distribution system of non-intelligent control cabinet. Summary of the invention

[0006] The purpose of the present invention includes, for example, providing a quantitative mixing system, which can reduce manual operations during liquid preparation, while improving liquid preparation efficiency and ensuring liquid preparation accuracy.

[0007] The embodiments of the present invention can be implemented as follows:

[0008] In a first aspect, the present invention provides a quantitative mixing system, comprising:

[0009] Original liquid container, infusion pipeline, delivery pump, mixing container, stirring device, weighing device and control device;

[0010] The delivery pump, the stirring device, and the weighing device are all electrically connected to the control device;

[0011] The inlet of the infusion pipeline is connected to the raw liquid container, the outlet of the infusion pipeline is connected to the mixing container, and the delivery pump is arranged on the infusion pipeline;

[0012] The stirring blades of the stirring device are arranged in the mixing container, and the weighing device is arranged at the bottom of the mixing container to measure the weight of the mixed liquid medicine in real time.

[0013] In an optional embodiment, a temperature measuring device is further included; the temperature measuring device is arranged in the mixing container to monitor the temperature of the mixed liquid.

[0014] In an optional embodiment, a moving frame is further included, the bottom of the weighing device is arranged on the moving frame, and the bottom of the mixing container is arranged on the top of the weighing device.

[0015] In an optional embodiment, the mobile frame is a cart.

[0016] In an optional embodiment, the raw liquid container is a disposable raw liquid bag.

[0017] In an optional embodiment, the delivery pump is a peristaltic pump.

[0018] In an optional embodiment, the stirring device includes a stirring blade and a magnetic rotation mechanism; the magnetic rotation mechanism can drive the stirring blade to rotate by magnetic force.

[0019] In an optional embodiment, the mixing container includes a mixing tank, which is arranged on the top of the weighing device; the mixing tank has a closed inner cavity for accommodating the medicinal solution; and the stirring blades of the stirring device can be arranged in the inner cavity.

[0020] In an optional embodiment, the mixing tank is made of stainless steel.

[0021] In an optional embodiment, the mixing container includes a box body and a mixing bag; the mixing bag can be arranged in the box body; and the stirring blades of the stirring device can be arranged in the mixing bag.

[0022] The beneficial effects of the embodiments of the present invention include, for example:

[0023] The quantitative mixing system can reduce the manual operation during liquid preparation, improve the efficiency of liquid preparation, and ensure the accuracy of liquid preparation.

[0024] The embodiments of the present invention can be implemented as follows:

[0025] In a first aspect, the present invention provides a quantitative mixing system, comprising:

[0026] The quantitative mixing system of this scheme includes a stock liquid container, an infusion pipeline, a delivery pump, a mixing container, a stirring device, a weighing device and a control device. The control device can control the cabinet weighing device to perform real-time weighing, and at the same time regulate the operation of the stirring device and the delivery pump; in this way, on the one hand, the liquid medicine in the mixing container can be fully stirred, and on the other hand, the liquid medicine in the mixing container can reach a preset weight to facilitate the operation of subsequent processes. In summary, the functions of the equipment are realized through the coordinated work of various devices. The main function of the high-precision quantitative mixing system is to quantitatively transport various stock liquids to the mixing tank, automatically perform quantitative mixing operations, and also perform liquid filling operations. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0028] Figure 1 Schematic diagram of the structure of the quantitative mixing system according to the first embodiment of the present invention;

[0029] Figure 2 This is a schematic diagram of the working principle of the quantitative mixing system according to the first embodiment of the present invention;

[0030] Figure 3 Schematic diagram of the structure of the quantitative mixing system of the second embodiment of the present invention;

[0031] Figure 4 Schematic diagram of the working principle of the quantitative mixing system of the second embodiment of the present invention.

[0032] Icons: 11-raw liquid container; 12-infusion pipeline; 13-delivery pump; 14-weighing device; 15-control device; 16-temperature measuring device; 17-mobile frame; 100-mixing container; 110-mixing tank; 111-inner cavity; 121-box; 122-mixing bag; 200-stirring device; 210-stirring blade; 220-magnetic rotating mechanism; 21-control cabinet; 22-human-machine interface; 23-pipe rack; 24-pipe clamp; 25-electric pipe clamp valve. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations.

[0034] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0035] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0036] In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear to indicate an orientation or position relationship, they are based on the orientation or position relationship shown in the accompanying drawings, or are the orientation or position relationship in which the product of the invention is usually placed when used. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0037] In addition, the terms “first”, “second”, etc., if used, are merely used to distinguish between the descriptions and should not be understood as indicating or implying relative importance.

[0038] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention may be combined with each other.

[0039] At present, when preparing stock solutions in the field of biopharmaceuticals, the method of manually transporting and weighing the liquid is usually adopted. In this process, there are:

[0040] ① In the past, the entire process of liquid preparation and mixing was basically completed manually, resulting in low production efficiency.

[0041] ② In the past, the control cabinet for measurement accuracy was not perfect enough and the measurement error was still large.

[0042] ③ In the past, the level of digital information management for liquid mixing was low.

[0043] ④ In the past, quantitative mixing operations were limited in location and had a small scope of application.

[0044] ⑤ In the past, transportation was done through stainless steel pipes, which were costly and had high requirements for cleaning and sterility.

[0045] In order to improve the above technical problems, a quantitative mixing system is provided in the following embodiments.

[0046] Embodiment 1

[0047] Please refer to Figure 1 This embodiment provides a quantitative mixing system, including a stock liquid container 11, an infusion pipeline 12, a delivery pump 13, a mixing container 100, a stirring device 200, a weighing device 14 and a control device 15. The delivery pump 13, the stirring device 200 and the weighing device 14 are all electrically connected to the control device 15; the inlet of the infusion pipeline 12 is connected to the stock liquid container 11, the outlet of the infusion pipeline 12 is connected to the mixing container 100, and the delivery pump 13 is arranged on the infusion pipeline 12; the stirring blade 210 of the stirring device 200 is arranged in the mixing container 100, and the weighing device 14 is arranged at the bottom of the mixing container 100 to measure the weight of the mixed liquid in real time.

[0048] The quantitative mixing system control device 15 of the present solution can control the weighing device 14 of the cabinet 21 to perform real-time weighing, and at the same time regulate the operation of the stirring device 200 and the delivery pump 13; in this way, on the one hand, the liquid medicine in the mixing container 100 can be fully stirred, and on the other hand, the liquid medicine in the mixing container 100 can reach a preset weight to facilitate the operation of subsequent processes. In summary, the functions of the equipment are realized through the coordinated work of various devices. The main function of the high-precision quantitative mixing system is to quantitatively transport various types of stock liquids to the mixing tank 110, automatically perform quantitative mixing operations, and also perform liquid filling operations.

[0049] See also Figure 1 and Figure 2 As can be seen from the figure, the quantitative mixing system also includes a chassis, which includes a control cabinet 21, an HMI human-machine interface 22, a delivery pump 13 (a peristaltic pump in this embodiment) and a pipe rack 23 arranged on the electrical box. The infusion pipeline 12, the delivery pump 13 and the control device 15 are arranged in the control cabinet 21.

[0050] In an optional embodiment, the stock liquid container 11 is a disposable stock liquid bag. The disposable stock liquid bag has higher cleanliness, is easy to replace, and is convenient for universal manufacturing to improve the convenience of production. During operation, only the disposable stock liquid bag needs to be replaced to complete the entire process, which significantly improves production efficiency.

[0051] In an optional embodiment, the quantitative mixing system further includes a temperature measuring device 16; the temperature measuring device 16 is disposed in the mixing container 100 to monitor the temperature of the mixed liquid medicine, so as to ensure the quality of the mixed liquid medicine.

[0052] In an optional embodiment, the quantitative mixing system further includes a mobile frame 17, the bottom of the weighing device 14 is arranged on the mobile frame 17, and the bottom of the mixing container 100 is arranged on the top of the weighing device 14. Optionally, the mobile frame 17 is a cart. The mobile frame 17 facilitates the movement and transportation of the mixing container 100, thereby improving the convenience of using the quantitative mixing system.

[0053] In an optional embodiment, the delivery pump 13 is a peristaltic pump. In an optional embodiment, the stirring device 200 includes a stirring blade 210 and a magnetic rotation mechanism 220; the magnetic rotation mechanism 220 can drive the stirring blade 210 to rotate by magnetic force.

[0054] Furthermore, a plug-in data transmission connector is provided between the mixing container 100 and the control cabinet 21 , so that the data of the stirring device 200 and the temperature measuring device 16 can be transmitted to the control device 15 in the control cabinet 21 in a timely and efficient manner.

[0055] It can also be seen from the figure that in an optional embodiment, the mixing container 100 includes a mixing tank 110, which is arranged on the top of the weighing device 14; the mixing tank 110 has a closed inner cavity 111 for containing the liquid medicine; and the stirring blade 210 of the stirring device 200 can be arranged in the inner cavity 111. In an optional embodiment, the material of the mixing tank 110 is stainless steel.

[0056] Furthermore, the delivery pipeline can be a disposable pipeline, which can ensure the cleanliness of the liquid during the delivery process, and facilitate the maintenance and care of the entire quantitative mixing system. Under the premise of ensuring the sterility and integrity of the mixing experiment, the use of disposable pipeline equipment such as the original liquid bag, pipeline, filter, etc. has the following three advantages: cheap and affordable: cheap, and no need for cleaning and maintenance; safety - to ensure a sterile environment; flexibility: the material to be used can be quickly replaced.

[0057] When in use, the working principle and process are introduced:

[0058] Preparation: Turn on the power of the high-precision quantitative mixing system, enter the production formula and production information on the touch screen of the human-machine interface 22, install the disposable delivery pipeline between the delivery pump 13 and the pipe rack 23, and install the corresponding stock liquid bag.

[0059] The quantitative mixing operation is as follows:

[0060] First quantitative mixing work:

[0061] Start the first quantitative mixing program, the peristaltic pump starts pumping the stock liquid through the control cabinet 21 of the intelligent pumping system, and finally pumps the stock liquid into the mixing tank 110. At the same time, the high-precision weighing device 14 weighs in real time, and the stirring device 200 runs to start the quantitative mixing work. When the difference e between the set pump liquid mass S and the actual pump liquid mass M reaches the set f value, the semi-difference approximation algorithm is enabled to replenish the liquid until the difference e reaches the specified deviation range, that is, the first quantitative mixing work is completed. At the same time, the weighing is reset to zero, and prepare for the second weighing.

[0062] Secondary quantitative mixing work:

[0063] Replace the stock liquid pipeline and start the second quantitative mixing program. Similar to the first quantitative mixing, perform the corresponding pumping and weighing work to complete the quantitative mixing. The subsequent quantitative mixing work is similar until the entire quantitative mixing work is completed.

[0064] Liquid filling operations:

[0065] After the quantitative mixing operation is completed, the on-site personnel can push the stainless steel mixing tank 110 to the liquid filling position to perform the liquid filling operation. At this time, the stirring device 200 along with the stainless steel mixing tank 110 is connected to the socket on one side of the control cabinet 21 through a plug-in data transmission connector for power supply and data transmission.

[0066] Embodiment 2

[0067] See also Figure 3 and Figure 4 The quantitative mixing system of this embodiment is substantially the same as that of the embodiment. The difference between the two is that the mixing container 100 in this embodiment includes a box body 121 and a mixing bag 122; the mixing bag 122 can be arranged in the box body 121; and the stirring blade 210 of the stirring device 200 can be arranged in the mixing bag 122.

[0068] Optionally, the chassis of this embodiment does not have a pipe rack 23, but a pipe clamp 24 and an electric pipe clamp valve 25 are provided on the chassis. Furthermore, the mixing bag 122 at this time adopts a disposable storage bag, so that the cleanliness of the entire mixing process can be guaranteed. The quantitative mixing system of this embodiment does not have a mobile frame 17. The weighing device 14 is provided on the base, and the base and the bottom of the chassis are integrated into one. The bottom of the base is provided with an adjustment support foot.

[0069] Preparation: Turn on the power of the high-precision quantitative mixing system, enter the production formula and production information on the touch screen of the human-machine interface 22, install the disposable delivery pipeline between the tube clamp 24 and the electric clamp valve 25, and install the corresponding stock liquid bag.

[0070] Quantitative mixing operation:

[0071] First quantitative mixing work:

[0072] Start the first quantitative mixing program, the peristaltic pump starts pumping the stock solution through the control of the intelligent pumping system, and finally pumps the stock solution into the quantitative mixing bag 122. At the same time, the high-precision weighing device 14 weighs in real time, and the magnetic stirring device 200 runs to start the quantitative mixing work. When the difference e between the set pump liquid mass S and the actual pump liquid mass M reaches the set f value, the semi-difference approximation algorithm is enabled to replenish the liquid until the difference e reaches the specified deviation range, that is, the first quantitative mixing work is completed. At the same time, the weighing is reset to zero, and the second weighing is prepared.

[0073] Secondary quantitative mixing work:

[0074] Replace the stock liquid pipeline and start the second quantitative mixing program. Similar to the first quantitative mixing, perform the corresponding pumping and weighing work to complete the quantitative mixing. The subsequent quantitative mixing work is similar until the entire quantitative mixing work is completed.

[0075] In summary, the embodiment of the present invention provides a quantitative mixing system, which has at least the following advantages:

[0076] ① In the past, the whole process of liquid preparation and mixing was basically completed manually, which resulted in low production efficiency. Now, the quantitative mixing system can assist manual work. Only the disposable stock liquid bag needs to be replaced manually in the middle of the process to complete the whole process, which significantly improves production efficiency.

[0077] ② In the past, the control cabinet 21 for metering accuracy was not perfect enough, and the metering error was still large. Now the quantitative mixing system is enabled, and the anti-shake control cabinet 21 scheme of the pipeline and the pump liquid algorithm scheme are used to control the accuracy of the control cabinet 21, which significantly reduces the metering error.

[0078] ③ In the past, the digital information management level of liquid mixing was low. Now, this quantitative mixing system adopts a combination of special quantitative mixing system control cabinet 21 software, PLC programmable control cabinet 21 and HMI human-machine interface 22, which significantly improves the digital information management level.

[0079] ④ In the past, the quantitative mixing operation location was limited and the scope of application was small. Now the quantitative mixing system is enabled, with the addition of a mobile weighing platform and a plug-in data transmission connector. The stainless steel mixing tank 110 is lifted onto the weighing platform by on-site personnel for liquid mixing. After completion, the on-site personnel can push the stainless steel mixing tank 110 to the liquid filling position for liquid filling operations. At this time, the stirring device 200 that comes with the stainless steel mixing tank 110 is connected to the socket on one side of the control cabinet 21 through a plug-in data transmission connector for power supply and data transmission. The power supply and data transmission of the stirring device 200 that moves with the tank body can be met at different positions, significantly enhancing the applicability and flexibility of the operation.

[0080] ⑤ In the past, stainless steel pipes were used for transportation, which were costly and had high requirements for cleaning and sterility. Now, this quantitative mixing system is used, which uses disposable stock bags, disposable pipes and disposable mixing bags 122. The mixing bags 122 can be directly used downstream, significantly reducing production costs and being convenient.

[0081] The above are only specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A quantitative mixing system, characterized in that: include: A raw liquid container (11), a liquid infusion pipeline (12), a delivery pump (13), a mixing container (100), a stirring device (200), a weighing device (14) and a control device (15); The delivery pump (13), the stirring device (200), and the weighing device (14) are all electrically connected to the control device (15); The inlet of the infusion pipeline (12) is connected to the original liquid container (11), the outlet of the infusion pipeline (12) is connected to the mixing container (100), and the delivery pump (13) is arranged on the infusion pipeline (12); The stirring blade (210) of the stirring device (200) is arranged in the mixing container (100), and the weighing device (14) is arranged at the bottom of the mixing container (100) to measure the weight of the mixed liquid medicine in real time.

2. The quantitative mixing system according to claim 1, characterized in that: It also includes a temperature measuring device (16); the temperature measuring device (16) is arranged in the mixing container (100) to monitor the temperature of the mixed liquid medicine.

3. The quantitative mixing system according to claim 1, characterized in that: It also comprises a moving frame (17), the bottom of the weighing device (14) is arranged on the moving frame (17), and the bottom of the mixing container (100) is arranged on the top of the weighing device (14).

4. The quantitative mixing system according to claim 3, characterized in that: The movable frame (17) is a cart.

5. The quantitative mixing system according to claim 1, characterized in that: The raw liquid container (11) is a disposable raw liquid bag.

6. The quantitative mixing system according to claim 1, characterized in that: The delivery pump (13) is a peristaltic pump.

7. The quantitative mixing system according to claim 1, characterized in that: The stirring device (200) comprises a stirring blade (210) and a magnetic rotation mechanism (220); the magnetic rotation mechanism (220) can drive the stirring blade (210) to rotate by magnetic force.

8. The quantitative mixing system according to any one of claims 1 to 7, characterized in that: The mixing container (100) comprises a mixing tank (110), and the mixing tank (110) is arranged on the top of the weighing device (14); the mixing tank (110) has a sealed inner cavity (111) for accommodating liquid medicine; and the stirring blade (210) of the stirring device (200) can be arranged in the inner cavity (111).

9. The quantitative mixing system according to claim 8, characterized in that: The mixing tank (110) is made of stainless steel.

10. The quantitative mixing system according to any one of claims 1 to 7, characterized in that: The mixing container (100) comprises a box body (121) and a mixing bag (122); the mixing bag (122) can be arranged in the box body (121); and the mixing blade (210) of the stirring device (200) can be arranged in the mixing bag (122).

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