Multi-component fungicides

Abstract

The present invention relates to a multi-component combination comprising at least two components, (1) a polyphenol-based component, and, as component (2), at least one fungicide selected from the group consisting of a QiI fungicide, a strobilurin fungicide, a SDHI fungicide, an azole fungicide and a morpholine fungicide. The combination optionally comprises, as component (3), one or more compounds selected from the group of protective fungicides and copper-based compounds. Thus, the present invention also relates to methods of using said combinations to form compositions and as beneficial agricultural materials, and to the use of polyphenol-based compounds to reduce the amount of fungicide required for the fungicidal efficacy of protective fungicide and / or copper-based compounds when systemic fungicide is used, and to the use of polyphenol-based compounds to reduce the fungicidal efficacy of the protective fungicide and / or copper-based compounds. And / or methods of reducing their amount or the necessity to combine them.

Description

[0001] Throughout this application, various publications are cited. The disclosures of the documents and publications cited herein are incorporated by reference into this application in their entirety. Technical Field

[0002] The present invention relates to fungicidal combinations comprising at least two components (1) a polyphenol-based component and (2) at least one fungicide component (A) selected from the following groups: QiI fungicides (QiI - endoquinone inhibitors); strobilurin fungicides (QoI - exoquinone inhibitor fungicides); formamide fungicides (SDHI - succinate dehydrogenase inhibitors); azole fungicides (DMI - demethylation inhibitors); morpholine fungicides; and mixtures thereof.

[0003] The fungicidal combination of the present invention may further comprise an additional component (3) selected from copper-based compounds; protectant fungicides such as fluazinam, chlorothalonil, mancozeb, sulfur, folpet, and captan; and combinations of both copper-based compounds and protectant fungicides. The present invention enables a reduction in the amount of copper-based compounds and / or protectant fungicides used with systemic fungicides, or even eliminates the need to use them, which generally results in equal or superior fungicidal activity while reducing the incidence of phytotoxicity.

[0004] Obviously, the present invention is therefore also related to several advantages obtainable by using polyphenol-based compounds: increasing plant health; enhancing the efficacy of systemic and / or protectant fungicides; and enabling a reduction in the amount of both systemic and protectant fungicides. This reduction achieved by using polyphenol-based compounds is most significant and / or significant for protectant fungicides.

[0005] While it has been found that the use of polyphenol-based compounds alone increases the efficacy of control; and increases plant health, additional advantages can be obtained when polyphenol-based compounds are optionally used in combination with even minimal amounts of copper-based compounds, which can further increase the consistency of control, improve performance and plant health, and in some cases, completely eliminate the need for protectant fungicides, notably without loss of efficacy and generally with reduced levels of phytotoxicity.

[0006] In this regard, when used, the amount of copper-based compound is about 1 g / ha-350 g / ha, typically in the range of about 5 g / ha-50 g / ha, or from about 8 g / ha to conventional use levels of copper-based compounds.

[0007] In some noted embodiments, amounts of less than 10 g / ha of metallic copper are more than sufficient.

[0008] Methods for controlling, treating or preventing fungal and / or bacterial diseases in crop plants using the combinations of the invention are also disclosed and are an integral part of the present invention. Background Art

[0009] Fungicides as defined herein are compounds of natural or synthetic origin that act to protect plants against damage caused by fungi and / or bacteria. Although the use of fungicides in agriculture brings benefits such as crop protection and improved productivity, it is currently desirable to reduce the amount of fungicides used in the field due to the potential health risks associated with the intensive use of agrochemicals. In particular, it is desirable to reduce the amount of either or both of the copper-based compounds and / or protectant fungicides that have been typically combined with systemic fungicides to date, without losing the benefits typically associated with their current use levels.

[0010] Furthermore, repeated use of a single fungicide often leads to the development of resistance to that fungicide.

[0011] Another important problem associated with fungal and / or bacterial attack is the accompanying nutrient loss, which results in a reduction in the overall yield of the crop.Compositions comprising a single active ingredient have shown limited control of diseases.

[0012] Many known fungicides are effective and have limited activity against specific crops. In addition, resistance has developed and there is a need to restore, revert, increase and / or prolong activity.

[0013] Therefore, there is a need for improved treatment or prevention of plant diseases caused by pathogens, which can also generally achieve higher yields while maintaining a high level of nutrients in the crop, while reducing the amount of fungicide required, in particular reducing protectant fungicides (such as any of mancozeb, chlorothalonil or fluazinam), and / or reducing copper-based compounds.

[0014] In particular, there is a need to reduce the amount of either or both of copper-based compounds and / or protectant fungicides hitherto typically included in fungicidal combinations of systemic fungicides, without reducing the fungicidal efficacy, while maintaining or even improving the level of treatment or prevention of plant diseases caused by pathogens, in particular enabling higher yields, abiotic stress relief and reduced phytotoxicity, while maintaining macronutrients in the crop.

[0015] By practicing the invention disclosed herein, the inventors unexpectedly discovered that the amount of all fungicides contained in the inventive combination can be reduced by 10%-50% without loss of efficacy when compared to the same combination of systemic and protectant fungicides without a polyphenol-based component. In experiments, it was found that a 20%-40% reduction in the application rate of all fungicides in the inventive combination according to the present invention did not result in a significant loss of efficacy.

[0016] This clearly provides significant environmental advantages by reducing the amount of agrochemicals applied, however in addition, unexpected plant health benefits have been noted with application of the compositions of the present invention, including effects like greening, longer leaf duration, more photosynthesis, and less environmental stress, to name just a few noted during field trials.

[0017] Importantly, the inventors have surprisingly found that it is possible to reduce by at least 25% the amount of mancozeb, thiophanate-methyl, and / or fluazinam which have hitherto been frequently combined with: systemic fungicides such as QiI fungicides (QiI - quinone internal inhibitors); strobilurin fungicides (QoI - quinone external inhibitors); formamide fungicides (SDHI - succinate dehydrogenase inhibitors); azole fungicides (DMI - demethylation inhibitors); morpholine fungicides and mixtures thereof.

[0018] For example, the reduction of mancozeb without loss of efficacy, for example, has further unexpected advantages in terms of the quality of the fungicidal composition containing the combination containing mancozeb. Mancozeb is typically present in the form of solid particles dispersed in the composition at high concentrations, and therefore a reduction in the mancozeb content will improve the formulation quality because fewer solids need to be stably accommodated. In addition, when the combination is sprayed at a lower mancozeb application rate, there is better dispersion and fungicide coverage. As previously mentioned, these advantages are in addition to the efficacy maintenance achieved by practicing the invention disclosed herein.

[0019] By practicing the present invention it has surprisingly been found that the reductions achieved in the levels of copper-based compounds heretofore combined with systemic fungicides are more pronounced when combined with polyphenol-based components, in many cases to levels significantly below 10 g / ha, without deleterious effects on the efficacy of the combination and with the unexpected benefit of reducing the high cost of copper-based compounds. Summary of the invention

[0020] The present invention provides a multi-component combination comprising at least two components (1) a polyphenol-based component and at least one (systemic) fungicide component (A) as component (2) selected from the following group: QiI fungicides (QiI - quinone internal inhibitors); strobilurin fungicides (QoI - quinone external inhibitors); formamide fungicides (SDHI - succinate dehydrogenase inhibitors); azole fungicides (DMI - demethylation inhibitors); and morpholine fungicides, with the proviso that the polyphenol-based component (1) contains a naturally derived or derived polyphenol-based compound and that lignin sulfonate (if present in the combination) is not the only polyphenol-based compound.

[0021] The combination of the present invention may further comprise an additional component (3) comprising one or more protectant fungicides, such as fluazinam, thiophanate-methyl, mancozeb, sulphur, folpet, captan; and all mixtures thereof. Component (3) may also or alternatively consist of one or more copper-based compounds.

[0022] When component (3) comprises one or more protectant fungicides in a mixture with the polyphenol-based systemic fungicides of component (1) and component (2), the absolute and / or relative content of the protectant fungicide in the combination can be reduced by at least 25% and advantageously almost eliminated without any deleterious effect on efficacy, and showing improved benefits, including benefits to crop plants or the loci to which they are applied, as well as improved pesticidal characteristics compared to mixtures of the same protectant fungicide and the same systemic fungicide.

[0023] When component (3) comprises one or more copper-based compounds, the combination with the polyphenol-based component (1) results in a reduction or advantageously elimination of the amount of protectant fungicide in the mixture with the systemic fungicide of component (2). Thus, the absolute and / or relative content of the protectant fungicide in the combination can be reduced by at least 25% and advantageously even eliminated without any detrimental effect on efficacy and showing improved benefits compared to mixtures of the same protectant fungicide and the same systemic fungicide, including benefits to the crop plants or the locus to which they are applied, as well as improved pesticidal characteristics.

[0024] Thus, some aspects of the invention are methods of reducing the amount of protectant fungicide to be included in a combination with a systemic fungicide, wherein the method comprises combining the systemic fungicide with a polyphenol-based compound.

[0025] The present invention also provides a multi-component combination comprising at least two components, (1) a certain amount of a polyphenol-based component, and (2) a certain amount of at least one (systemic) fungicide component (A) selected from the group consisting of:

[0026] (a) QiI fungicide;

[0027] (b) Strobilurin fungicides (QoI fungicides)

[0028] (c) succinate dehydrogenase inhibitor (SDHI) fungicides;

[0029] (d) triazole (azole) fungicides (DMI);

[0030] (e) morpholine fungicides; and

[0031] (f) any mixture thereof;

[0032] wherein the combination is more effective in treating plants or soil against fungal and / or bacterial diseases than the same amount of each component of the combination applied alone, provided that the polyphenol-based component (1) contains at least one polyphenol that is not a lignin sulfonate and that the lignin sulfonate (if present in the combination or in a composition comprising the combination) is not the only polyphenol-based compound.

[0033] The present invention also provides a multi-component combination comprising at least two components, (1) a certain amount of a polyphenol-based component, and (2) a certain amount of at least one (systemic) fungicide component (A) selected from the group consisting of:

[0034] (a) QiI fungicide;

[0035] (b) Strobilurin fungicides (QoI fungicides)

[0036] (c) succinate dehydrogenase inhibitor (SDHI) fungicides;

[0037] (d) triazole (azole) fungicides (DMI);

[0038] (e) morpholine fungicides; and

[0039] (f) any mixture thereof;

[0040] wherein the combination is more effective in treating plants or soil against fungal and / or bacterial diseases than the same amount of each component of the combination applied alone, provided that the polyphenol-based component (1) contains a polyphenol-based compound of natural origin and the lignin sulfonate (if present in the combination or in a composition comprising the combination) is not the only polyphenol-based compound.

[0041] The present invention further provides a multi-component combination comprising at least two components,

[0042] (1) Polyphenol-based components and

[0043] (2) at least one fungicide (A) selected from the group consisting of:

[0044] (a) QiI fungicide;

[0045] (b) strobilurin fungicides;

[0046] (c) succinate dehydrogenase inhibitor (SDHI) fungicides;

[0047] (d) triazole fungicides;

[0048] (e) morpholine fungicides; and

[0049] Any and all mixtures of two or more of (a)-(e); and optionally,

[0050] (3) A compound selected from the following group,

[0051] i. Protectant fungicide;

[0052] ii. Copper-based compounds; and

[0053] iii. any and all mixtures thereof;

[0054] wherein the combination is more effective in treating plants or soil against fungal diseases than the same amount of each fungicide when applied alone or as a mixture of fungicides (without the polyphenol-based component), provided that the polyphenol-based component (1) contains a naturally-sourced or derived polyphenol-based compound and the lignin sulfonate (if present in the combination or in a composition comprising the combination) is not the only polyphenol-based compound.

[0055] Furthermore, the present invention also provides a combination comprising at least two components,

[0056] Component (1) a certain amount of a polyphenol-based component,

[0057] Component (2) an amount of at least one fungicide component (A) selected from the group consisting of:

[0058] (a) QiI fungicide;

[0059] (b) strobilurin fungicides (QoI fungicides);

[0060] (c) succinate dehydrogenase inhibitor (SDHI) fungicides;

[0061] (d) triazole (azole) fungicides (DMI);

[0062] (e) morpholine fungicides; and

[0063] (f) mixtures of two or more thereof;

[0064] The combination optionally or advantageously further contains an additional component (3) selected from the group consisting of:

[0065] (g) protectant fungicides, for example fluazinam, chlorothalonil, mancozeb, sulphur, folpet, and captan;

[0066] (h) copper-based compounds; and

[0067] (i) any and all mixtures thereof,

[0068] Provided that the polyphenol-based component (1) contains at least one, preferably naturally-derived or naturally-derived, polyphenol-based compound which is not a lignin sulfonate and that the lignin sulfonate, if present in the combination or in a composition comprising the combination, is not the only polyphenol-based compound.

[0069] Furthermore, the present invention provides a combination wherein the amount of the polyphenol-based component (1) and the amount of the fungicide (A) of component (2) are more effective in treating or protecting plants or soil against fungal and / or bacterial infection if applied together than the same amount of each component applied alone, and wherein the amount of component (3) (when present) is reduced (or can be reduced without deleterious effect) compared to a comparable fungicidal combination comprising the same amount of the fungicide (A) of component (2) in which the polyphenol-based component (1) is not present.

[0070] However, for the sake of clarity, the addition of excess active ingredients of component (3) or amounts thereof that are excess to the requirements to the combinations of the present invention will not remove these combinations from the intended scope of the present invention.

[0071] Thus, the present invention also provides a method comprising the use of a polyphenol-based material to enable a reduction in the amount of copper-based compounds and / or protectant fungicides typically included in fungicidal mixtures with systemic fungicides.

[0072] In several three-component embodiments of the present invention, the combination of the present invention comprises a mixture of a polyphenol-based component (1) with one or both of a copper-based compound and a protectant fungicide, and component (3) is combined with a separately prepared component (2) comprising a systemic fungicide (A). Thus, the present invention also includes a mixture of component (1) alone with component (3), but is particularly adapted for use in combination with one or more component (2) systemic fungicides, for example as part of a kit, or otherwise adapted for use in combination with one or more component (2) systemic fungicides to prepare a three-component embodiment of the combination of the present invention.

[0073] Of note is the combination of the polyphenol-based component (1) with the copper-based component (3) compounds, intended or indicated or otherwise adapted for use in systemic fungicide combinations with the individual combinations of component (2), or in systemic and protectant fungicide combinations with the individual combinations of components (2) and (3) combined. DETAILED DESCRIPTION

[0074] definition

[0075] Before explaining the present subject matter in detail, it may be helpful to provide definitions of certain terms used herein. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the present subject matter relates.

[0076] Throughout this application, descriptions of various embodiments use the term "comprising"; however, those skilled in the art will appreciate that, in some specific cases, the language "consisting essentially of" or "consisting of" may alternatively be used to describe the embodiments.

[0077] Generally, the phrase "selected from the group consisting of" has been used in the present disclosure when referring to a list of options or optional choices of ingredients, etc., however, in all cases, the corresponding phrase "selected from the group consisting of" is specifically intended as an option, and vice versa, unless the context requires a specific interpretation.

[0078] All disclosures of lists of optional ingredients etc. should be considered as closed and open list disclosures, as an alternative to two separate disclosures.

[0079] Unless otherwise specifically stated, the terms "a / an" as used herein include the singular and the plural. Therefore, the terms "a / a", "an", or "at least one" may be used interchangeably in this application, and for clarity, the use of the terms "a / a" or "an" is not intended to convey the absence of a plurality unless the context requires.

[0080] For the purpose of better understanding the present teaching content and in no way limiting the scope of these teaching contents, unless otherwise indicated, all numerical values ​​representing amounts, percentages or ratios and other numerical values ​​used in the specification and claims should be understood to be modified by the term "about" in all cases. Therefore, unless otherwise indicated to the contrary, the numerical parameters listed in the following specification and the attached claims are approximate values, which can vary according to the desired characteristics sought to be obtained. At a minimum, each numerical parameter should at least be interpreted in accordance with the number of reported significant figures and by applying ordinary rounding techniques. The inventors intend to report values ​​that are rounded to no more than one decimal place. Although every effort has been made to avoid errors, if a numerical value disclosed herein is mistakenly recorded as having more than one digit after a decimal point, it should be considered an inadvertent error and the number should be understood to be the value rounded up or down to the maximum value of a single digit after the decimal point, for example, in the present disclosure, a typographical error recording the number "147.4821" should be understood as the inventors intended to refer to the correct value of "148", unless the context clearly indicates that 147.5 is required. Similarly, values ​​that are actually less than 0.05 will of course be recorded so as not to be recorded as zero values, for example, 0.02 will not be rounded to 0.0.

[0081] As used herein, "about" includes the stated value and means an acceptable range of deviation for a particular value determined by one of ordinary skill in the art taking into account the measurement in question and the error associated with the measurement of the particular quantity (i.e., the limitations of the measurement system). For example, "about" can mean within one or more standard deviations, or within ±30%, ±20%, ±10%, or ±5% of the stated value.

[0082] In this regard, the term "about" as used herein specifically includes ±10% of the indicated value in the range, and unless clear from the context, the term about should be understood as ±10% of the indicated value.

[0083] In addition, the endpoints of all ranges involving the same component or characteristic herein include the endpoints, are independently combinable, and specifically include all intermediate points and ranges. Therefore, it should be understood that when providing a parameter range, the present invention also provides all integers and tenths within the range, and as with all numbers, generally recognized numerical rounding principles should be adopted. For example, the range of "10%-50%" specifically includes 9.5%, 10%, 10.1%, 10.2%, etc., up to 50.4%.

[0084] As used herein, the term "and / or" includes any and all combinations of one or more of the listed associated items. When a statement such as "at least one of..." precedes a list of elements, it modifies the entire list of elements and does not modify the individual elements in the list.

[0085] It should be understood that when an element is referred to as being "on" another element, it can be directly in contact with the other element, or there can be intervening elements between them. On the contrary, when an element is referred to as being "directly on" another element, there are no intervening elements that may create obstacles between them.

[0086] It should be understood that, although the term first, second, third etc. can be used to describe various elements, components, regions, layers and / or sections in this article, these elements, components, regions, layers and / or sections should not be limited by these terms. These terms are only used to distinguish an element, component, region, layer or section from another element, component, region, layer or section. Therefore, without departing from the teaching content of embodiments of the present invention, the first element, component, region, layer or section discussed below can be referred to as the second element, component, region, layer or section.

[0087] The terms used herein are only used for the purpose of describing or illustrating specific embodiments and are not intended to be limiting. As used herein, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise.

[0088] The term "or" means "and / or", unless the context requires otherwise. It should be further understood that the terms "comprises and / or comprising", or "includes and / or including", or "contains and / or containing", if used in this specification, specify the presence of the features, regions, integers, steps, operations, elements, and / or components, but do not exclude the presence or addition of one or more other features, regions, integers, steps, operations, elements, components, and / or groups thereof.

[0089] Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by those of ordinary skill in the art to which this general inventive concept belongs. It will be further understood that terms such as those defined in commonly used dictionaries should be interpreted as meanings consistent with their meanings in relevant technical field documents and this disclosure, and will not be interpreted as idealized or overly formal meanings unless explicitly defined herein.

[0090] As used herein, the term "mixture" with respect to agricultural chemicals includes, but is not limited to, a collection of agricultural chemicals that are typically applied by simultaneous, contemporaneous, concomitant, sequential and / or continuous / sequential application.

[0091] Thus, the term "mixture" with respect to a component includes a combination of the individual components at any time of administration, such as simultaneous, contemporaneous, concomitant, and / or continuous / sequential administration and / or in any physical form (e.g., composition, blend, solution, suspension, dispersion, emulsion, alloy, etc.). Mixtures and mixing may also refer to combining and administering the active components as a composition and / or formulating each active component in a mixture or combination as a separate composition and administering simultaneously or at the same time or at different times in separate administrations, and mixtures of these components may be provided in a kit or otherwise adapted to the combination according to the invention.

[0092] As used herein, the term "simultaneously" means that the agrochemical (of a mixture) is applied as an admixture (e.g., a tank mix) if used in conjunction with the application of an agrochemical. For simultaneous application, the combination (mixture) can be an admixture itself, or separate containers each containing an agrochemical component or a mixture of some components, which are combined prior to application, typically provided as a kit, or otherwise adapted for end-use combination.

[0093] As used herein, if used in conjunction with the application of an agrochemical (of a mixture), the term "contemporaneous" means that it is possible to apply an individual agrochemical separately with another agrochemical or premix at the same time or apply them together at a sufficiently close time so that a synergistic activity or an additive or greater than additive activity is achieved relative to the activity of either agrochemical alone at the same dose.

[0094] As used herein, the term "consecutive" or "sequentially" if used in connection with the application of (combined) agrochemicals means that individual agrochemicals are applied one after the other at separate application start times.

[0095] As used herein, the specific term "fungicidally effective amount" of an active ingredient refers to the amount of the active ingredient commercially recommended for use, for example, in controlling relevant fungi on relevant crops. However, in some cases, it will be clear from the context that the fungicidally effective amount is a reduced but still effective amount of the active ingredient achieved by practicing the present invention compared to the commercially recommended amount. The commercially recommended amount of each active ingredient (usually specified as the application rate of a commercial formulation) can be found on the label attached to the commercial formulation. The commercially recommended application rate of a commercial formulation may vary depending on factors such as the plant species and the fungus to be controlled.

[0096] For example, if a fungicide concentrate composition containing 300 g / L of a single fungicidal ingredient is commercially available to treat a particular fungal infection in a particular crop, and an application of 800 g ai / ha is recommended, then an amount of the fungicide below that amount would be considered below its fungicidally effective amount.

[0097] Generally, if application of a particular amount of a particular fungicide achieves less than 70% control of a particular fungal pathogen (less than 70% efficacy) in a particular crop, the amount of the fungicide is considered to be less than a fungicidally effective amount.

[0098] Of course, when stubborn or difficult to treat fungal infections are contemplated, the level of control is based on industry standards, so if the maximum level of control achievable to date for a particular single fungicide against a particular fungal infection is significantly less than 80% control, then the term less than fungicidally effective amount will be based on the amount known to achieve that maximum level of control.

[0099] As used herein, the term "protectant fungicide" does not include copper-based compounds, although the term is generally understood to include these classes of compounds as well. However, in the specific context of the present invention, where copper-based compounds are typically used advantageously in amounts significantly less than the fungicidally effective amount, the class of copper-based fungicides is treated separately from other protectant fungicides and, strictly for the purposes of the present invention, will not be referred to as "protectant fungicides," even though they belong to a chemical class known to have this function.

[0100] As used herein, the term "treating plants or soil to resist fungal infection" includes, but is not limited to, protecting plants or soil from fungal attack, preventing fungal infection of plants or soil, controlling fungal diseases that infect plants or soil, and reducing fungal infection of plants or soil.

[0101] As used herein, the term "more effective" includes, but is not limited to, increasing the efficacy of fungal disease control, prolonging protection and reducing the amount of time required to achieve a given level of fungal control, prolonging the duration of protection from fungal attack after application and prolonging the period of protection from fungal attack and / or reducing the amount of time required to achieve a certain level of fungal control compared to when the same amount of each fungicide is applied alone.

[0102] As used herein, if used in conjunction with any combination, mixture or composition, the term "effective" can be, but is not limited to, any of the following: effective in controlling fungal diseases, effective in preventing fungal diseases, effective in reducing the time for effective control of fungal diseases, effective in reducing the amount of fungicide required for effective control of fungal diseases, effective in extending the control effect of a single combination, mixture and / or composition in the mixture on crops and disease types, effective in extending the control effect time of the mixture on crops and disease types compared to a single combination, mixture and / or composition in the mixture, and effective in extending the control effect time of a single combination, mixture and / or composition in the mixture on crops and disease types.

[0103] As used herein, the term "effective amount" typically refers to an amount of an agrochemical composition or mixture that is sufficient to control harmful fungi on crop plants without causing significant damage to the treated crop plants.

[0104] As used herein, the term "agriculturally acceptable carrier" means a carrier known and accepted in the art for forming compositions for agricultural or horticultural use.

[0105] As used herein, the term "adjuvant" is broadly defined as any substance that is not itself an active ingredient but enhances or is intended to enhance the effectiveness of the pesticide with which it is used. Adjuvants may be understood to include, but are not limited to, spreaders, penetrants, compatibilizers, and drift retardants.

[0106] As used herein, the term "agriculturally acceptable inert additive" is defined as any substance that is not an active ingredient itself but is added to the composition, such as thickeners, stickers, surfactants, antioxidants, defoamers and thickeners.

[0107] As used herein, the term "tank mix" means that one or more chemical pesticides or compositions are mixed in a spray tank at the time of spray application.

[0108] As used herein, the term "premix" means a composition that can be applied directly to plants after dilution. The composition comprises a combination of active ingredients.

[0109] As used herein, the term "plant" or "crop" includes reference to agricultural crops, including field crops (soybean, corn, wheat, rice, etc.), vegetable crops (potato, cabbage, etc.), fruit trees (peach trees, etc.), semi-perennial crops (sugar cane), and perennial crops (coffee and guava).

[0110] As used herein, the term "plant" or "crop" includes reference to whole plants, plant organs (e.g., leaves, stems, twigs, roots, trunks, branches, shoots, fruits, etc.), plant cells, seedlings, cuttings or plant seeds. This term also includes plant crops such as fruits.

[0111] The term "plant" may also include its propagation material, which may include all reproductive parts of the plant, such as seeds, and vegetative plant material that may be used to multiply the plant, such as cuttings and tubers. The term may also include spores, corms, bulbs, rhizomes, sprouts, basal branches, runners, and buds and other parts of the plant, including seedlings and young plants, which will be transplanted after germination, rooting, or after emergence from soil or any other type of substrate (artificial or natural).

[0112] As used herein, the term "propagation material" is understood to mean all reproductive parts of a plant, such as seeds and spores; vegetative structures, such as bulbs, corms, tubers, rhizomes, roots stems, basal shoots, stolons and shoots.

[0113] As used herein, the term "locus" includes not only areas that may have shown fungal infection / disease, but also areas that have not shown fungal infection / disease, and also areas under cultivation. The locus includes, but is not limited to, soil and other plant growth media.

[0114] As used herein, the term "locus" includes a habitat, propagation area, plant, propagation material, soil, area, material or environment where a fungal disease is growing or may grow.

[0115] As used herein, the term "ha" refers to hectares.

[0116] As used herein, the terms "control" or "treatment" include, but are not limited to, preventing fungal diseases, protecting plants from fungal diseases, delaying the onset of fungal diseases, and combating or killing fungal diseases. They may also include the therapeutic and / or eradication of ongoing fungal and / or bacterial diseases by compounds and compositions. Control of fungal diseases that infect plants, propagation materials of plants, or the locus of plants, control of plant or soil diseases caused by phytopathological fungi and / or bacteria (pathogens), control of fungal attack on plants or propagation materials of plants, or the locus of plants includes therapeutic applications and / or protectant / preventive applications and / or persistent applications.

[0117] As used herein, the term "applying" or "application" includes, but is not limited to, applying compounds and compositions (including those of the present invention) to plants, sites of fungal and / or bacterial infection, potential sites of fungal and / or bacterial infection (which may need protection from infection), or the environment surrounding fungal and / or bacterial habitats or potential habitats. It also includes reference to the activity of compounds and compositions on plants and fungal and / or bacterial tissues in contact therewith. The application can be carried out by the methods described in the present invention, such as by spraying, dipping, etc.

[0118] As used herein, the term "therapeutic application" refers in particular to the application of one or more compounds (including fungicides) to control fungal and / or bacterial infections of plants or loci, wherein the fungicidal combination, mixture or composition is applied after infection or after disease symptoms are displayed, and wherein the fungal and / or bacterial infection reduces and / or cures plant or soil diseases caused by phytopathogenic fungi and / or bacteria.

[0119] As used herein, the term "therapeutic treatment" or "therapeutic activity" means the application of one or more pesticides, and in particular fungicidal materials, for controlling pest infestation of plants or loci after infection or after disease symptoms are displayed and / or when disease pressure is high. Disease pressure can be assessed based on conditions associated with disease development, such as spore concentration and certain environmental conditions. In some embodiments, the pests are fungi and / or bacteria.

[0120] As used herein, the term "protectant application" means the application of one or more fungicidal combinations, mixtures or compositions for preventing fungal and / or bacterial infection of a plant or locus, wherein the fungicidal combination, mixture or composition is applied before infection / disease occurs, before any disease symptoms are displayed, or when disease pressure is low. Disease pressure can be assessed based on conditions associated with disease development, such as spore concentration and certain environmental conditions.

[0121] As used herein, the term "preventative treatment" or "preventative activity" means applying one or more pesticides for controlling pest infestation of plants or loci prior to infection or before disease symptoms are shown and / or when disease pressure is low. Disease pressure can be assessed based on conditions associated with disease development, such as spore concentration and certain environmental conditions. In some embodiments, the pests are fungi and / or bacteria.

[0122] As used herein, the term "cultivated plants" includes plants that have been modified by breeding, mutagenesis or genetic engineering. Genetically modified plants are plants whose genetic material has been modified using recombinant DNA techniques. Typically, one or more genes have been integrated into the genetic material of such plants in order to improve certain properties of the plant.

[0123] The term "plant health" includes various plant improvements that are not related to pest control. For example, favorable properties that may be mentioned are improved crop characteristics, including: emergence, crop yield, protein content, oil content, starch content, more developed root system (improved root growth), improved stress resistance or improved abiotic stress relief (e.g., for drought, heat, salt, UV, water, cold), reduced ethylene (reduced production and / or inhibition of uptake), increased plant height, larger leaves, fewer dead basal leaves, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less input required (e.g., fertilizer or water), less seeds required, more effective tillers, earlier flowering, earlier grain maturity, fewer plant segments (lodging), shorter stalks, increased stalk diameter, increased shoot growth, enhanced plant vigor, increased plant density, and earlier and better germination; or any other advantages familiar to those skilled in the art.

[0124] As used herein, the phrase "agriculturally acceptable carrier" means a carrier known and accepted in the art for formulating compositions for agricultural or horticultural uses.

[0125] In some embodiments, the disease is a fungal disease.

[0126] In some embodiments, the infection is a disease and / or a disease caused by a pathogen.

[0127] As used herein, the term "enhancing crop plants" means improving one or more of the following: plant quality, plant vigor, nutrient uptake, root system, tolerance to stress factors or improved abiotic stress reduction, and / or yield of plants to which a mixture or composition as described herein is applied, compared to control plants grown under the same conditions except that the mixture or composition as described herein is not applied.

[0128] As used herein, the term "improving plant quality" means that one or more traits of a plant to which a mixture or composition as described herein is applied are qualitatively or quantitatively improved compared to the same traits of a control plant grown under the same conditions except that the mixture or composition as described herein is not applied. Such traits include, but are not limited to, improved visual appearance and composition of the plant (i.e., improved color, density, uniformity, compactness), reduced ethylene (reduced production and / or inhibited uptake), improved visual appearance and composition of harvested material (i.e., seeds, fruits, leaves, vegetables, shoots / stems / canes), improved carbohydrate content (i.e., increased amount of sugars and / or starch, improved sugar-acid ratio, reduction in reducing sugars, increased rate of sugar formation), improved protein content, improved oil content and composition, improved nutritional value, reduction in anti-nutritional compounds, increased nutrient absorption, stronger and healthier roots, improved organoleptic properties (i.e., improved taste), improved consumer health benefits (i.e., increased vitamin and antioxidant levels), improved post-harvest characteristics (i.e., increased shelf life and / or enhanced storage stability, easier processing, easier extraction of compounds), and / or improved seed quality (i.e., for use in the following season).

[0129] As used herein, the term "plant growth regulation" or "regulating plant growth" includes limiting vertical stem growth, promoting root growth, stunting growth, increasing stem diameter and stem wall thickness, and the like.

[0130] As used herein, the term "plant" refers to any and all physical parts of a plant, including, but not limited to, seeds, seedlings, saplings, roots, tubers, stems, stalks, leaves, and fruit.

[0131] Combinations and mixtures

[0132] The present invention provides a combination generally referred to as a multi-component combination, which comprises at least two components, (1) a certain amount of a polyphenol-based component, and a certain amount of at least one fungicide (A) as component (2), which typically refers to a systemic fungicide selected from the group consisting of: QiI fungicides; strobilurin fungicides (QoI); SDHI fungicides; azole fungicides (DMI); and morpholine fungicides.

[0133] Combination Example #1

[0134] In the noted embodiments, the combinations of the invention typically comprise an additional component (3) compound selected from the group of protectant fungicides, such as fluazinam, thiophanate-methyl, mancozeb, sulphur, folpet, captan; and mixtures thereof and / or copper-based compounds, wherein the amount of polyphenol-based component (1) and the amount of component (2) (systemic) fungicide component (A) if applied together are more effective in treating or protecting plants or soil against fungal and / or bacterial infection than the same amount of each component applied alone, and wherein the amount of component (3) compound (when present) is reduced without loss of efficacy and typically with increased activity and benefit compared to a comparable fungicidal combination comprising the same amount of one or more fungicide components (A) (wherein the polyphenol-based component is not present).

[0135] In the noted embodiments, when a fungicidal mixture is included in the fungicidal combination of the present invention comprising components (1), (2) and (3), the reduction of protectant fungicide and or copper achieved by the combination of the present invention can result in the following exemplary amount ranges in the fungicidal mixture.

[0136] Fluazifop, about 200 g / ha-500 g / ha, typically about 300 g / ha,

[0137] Thiophanate, about 400 g / ha-1200 g / ha, sometimes about 1000 g / ha, typically about 700 g / ha,

[0138] Mancozeb, about 400 g / ha to 1500 g / ha, sometimes about 900 g / ha, typically about 700 g / ha, or

[0139] Metallic copper, amounts ranging from about 1 g / ha to 350 g / ha, typically in the range of about 5 g / ha to 50 g / ha, and in some noted embodiments, less than 10 g / ha of metallic copper are more than sufficient.

[0140] discuss

[0141] Those skilled in the art will immediately understand and appreciate that the above protectant fungicides, including ethylene bisdithiocarbamate (EBDC) (e.g., mancozeb) amounts are significantly reduced compared to known mixtures with systemic fungicides, and the amounts of metallic copper are significantly reduced compared to those heretofore encountered in previously known fungicidal mixtures of protectant fungicides and / or copper with systemic fungicides.

[0142] Without being bound by theory, in the multi-component combination of the present invention, wherein the copper-based compound is included in component (3), the copper compound may act synergistically with the polyphenol-based component (1) to enhance the fungicidal effect of the polyphenol-based component (1) on the fungicide (A) compound of component (2), rather than the copper-based compound having significant fungicidal activity itself, which may explain why such a reduced amount of copper in the combination of the present invention is sufficient to achieve the desired efficacy.

[0143] Without being bound by theory, in the multi-component combinations of the present invention, where copper compounds are included in component (3), they may synergize with the polyphenol-based component (1) to become so fungicidally enhanced that significantly reduced amounts of copper in the combinations of the present invention are sufficient to achieve copper-based fungicidal efficacy levels typically encountered with fungicidal combinations containing much higher copper contents.

[0144] The ability to significantly reduce copper content in these types of inventive combinations, even if fungicidal efficacy remains equivalent, is itself advantageous not only due to reduced material costs but also allows for reduced potential for phytotoxicity and environmentally deleterious effects.

[0145] Without wishing to be bound by theory, in the multi-component combination of the present invention, wherein the protectant fungicide compound as defined above is contained in component (3), the protectant fungicide acts synergistically with the polyphenol-based component (1), enhancing the effect of the polyphenol-based component (1) on the fungicidal efficacy of the (systemic) fungicide (A) compound of component (2), rather than having fungicidal activity alone. While not wishing to be bound by any theory, this enhancement may explain why reduced amounts of the protectant fungicide are sufficient to achieve the desired efficacy in the combination of the present invention.

[0146] Without being bound by theory, in the multi-component combinations of the present invention, where the protectant fungicide compounds as defined above are contained in component (3), they may synergize with the polyphenol-based component (1) to become so fungicidally enhanced that a significantly reduced amount of the protectant fungicide compound in the combination of the present invention is sufficient to achieve the fungicidal efficacy levels normally encountered with fungicidal combinations containing much higher protectant fungicides.

[0147] The ability to reduce the protectant fungicide content in these types of inventive combinations is itself particularly advantageous, even if fungicidal efficacy remains equal, not only due to reduced material costs but also due to reduced potential for phytotoxicity and environmentally deleterious effects.

[0148] Combination Example #2

[0149] In some noted embodiments of previously known mixtures of a group of fungicides based on ethylenebisdithiocarbamate (EBDC) together with systemic fungicides (e.g. strobilurins and / or triazoles), additional combinations of the present invention with polyphenol-based compounds can allow the content of EBDC fungicide to be reduced by 25% or more compared to the "fungicidally effective amount" as defined herein without loss of activity.

[0150] In some noted embodiments of previously known mixtures based on ethylenebisdithiocarbamate (EBDC), a group of fungicides together with systemic fungicides (e.g., strobilurin and / or triazole), additional combinations of the invention with polyphenol-based compounds can allow the content of all or each of EBDC, strobilurin fungicides and / or triazole fungicides to be reduced by between about 10%-50% without loss of activity, compared to the fungicidally effective amount of the same combination of ethylenebisdithiocarbamate (EBDC), fungicides together with the same systemic fungicides. Most commonly, the reduction in fungicide content is between about 20% and about 40% without loss of fungicidal efficacy.

[0151] Typically, the fungicidal performance levels encountered with these inventive combinations of systemic fungicides having reduced levels of EBDC protectant fungicides are actually improved when combined with polyphenol-based compounds compared to mixtures of the same systemic fungicides having previously encountered non-reduced levels of the same EBDC protectant fungicides without the polyphenol-based compounds.

[0152] As an example, the present invention also provides a multi-component combination with improved effectiveness, which comprises at least (1) a certain amount of a polyphenol-based component, and as component (2) a certain amount of at least one (typically systemic) fungicide selected from the following group:

[0153] (a) QiI fungicide;

[0154] (b) strobilurin fungicides (QoI fungicides);

[0155] (c) succinate dehydrogenase inhibitor (SDHI) fungicides;

[0156] (d) triazole (azole) fungicides (DMIs); and

[0157] (e) morpholine fungicides;

[0158] and optionally an additional component (3) comprising at least one of the following,

[0159] (g) a protectant fungicide, for example at least one of fluazinam, chlorothalonil, mancozeb, sulphur, folpet and captan; and

[0160] (h) copper-based compounds; and

[0161] (i) any and all mixtures thereof;

[0162] Wherein these combinations are more effective in treating plants or soil against fungal and / or bacterial diseases than the same amount of each component applied alone, and where the amount of compound comprising component (3), if present, is advantageously reduced compared to the amount in previously encountered fungicidal combinations.

[0163] As an example, the present invention also provides a combination of at least two components, (1) a certain amount of a polyphenol-based component, and a certain amount of at least one fungicide (A) selected from the following group as component (2):

[0164] (a) QiI fungicide;

[0165] (b) strobilurin fungicides (QoI fungicides);

[0166] (c) succinate dehydrogenase inhibitor (SDHI) fungicides;

[0167] (d) triazole (azole) fungicides (DMIs); and

[0168] (e) morpholine fungicides;

[0169] Wherein, if applied together or synergistically, the amount of the polyphenol-based component (1) and the amount of the fungicide (A) comprising component (2), etc., are more effective in treating plants or soil against fungal and / or bacterial infections than applying the same amount of each component alone without applying the other component.

[0170] As an embodiment, the present invention also provides a combination comprising at least two components

[0171] (1) a certain amount of a polyphenol-based component, and a component

[0172] (2) an amount of at least one systemic fungicide (A) selected from the group consisting of:

[0173] (a) QiI fungicide;

[0174] (b) strobilurin fungicides (QoI fungicides);

[0175] (c) succinate dehydrogenase inhibitor (SDHI) fungicides;

[0176] (d) triazole (azole) fungicides (DMI);

[0177] (e) morpholine fungicides;

[0178] (f) A mixture of any two or more of (a) to (e),

[0179] The amount of at least one fungicide (A) in the combination, and advantageously the amount of all fungicides (A) in the combination, is less than the fungicidally effective amount of each fungicide (A) compound when the fungicides (A) are used alone and not in combination.

[0180] In some embodiments, wherein the combination comprises a third component (3), the third component comprises,

[0181] g) at least one protective fungicide or mixtures thereof, for example fluazinam, chlorothalonil, mancozeb, sulphur, folpet, or captan, and / or

[0182] h) copper-based compounds,

[0183] i) a mixture of any two or more of (g) and (h),

[0184] The amount of protectant fungicide and / or copper compound in the combination is less than the fungicidally effective amount of the protectant fungicide and / or copper-based compound when the protectant fungicide and / or copper is used alone with the same fungicide (A) without being combined with the polyphenol-based component (1), or when the fungicide mixture of component (2) is used in the absence of the polyphenol-based component (1).

[0185] In one aspect of an embodiment of the present invention, a minimum amount, for example 50 g / ha or less of metallic copper is used in component (3) to enhance the fungicidal enhancement effect of the polyphenol-based compound of component (1) on the systemic fungicide (A) of component (2).

[0186] Without wishing to be bound by any theory, it may be that the copper-based compounds change their functionality when combined with the polyphenol-based compounds and that they themselves have no significant antifungal effect in the combination, but as explained above, are only able to significantly enhance the activity of the polyphenol-based component in improving the fungicidal activity of the systemic fungicide (A), which may explain why such a drastic reduction in copper is possible in the inventive combinations disclosed herein.

[0187] In some embodiments, when the combination comprises two or more fungicides (A) as component (2), the amount of any, one, two or all fungicides (A) in the combination is less than the amount of using only one fungicide (A).

[0188] As an example, the present invention also provides a combination comprising at least two components (1) a certain amount of a polyphenol-based component, and a certain amount of at least one fungicide (A) selected from the following group as component (2):

[0189] (a) one or more QiI fungicides, such as imidazole, pyridinamide and sulfonamide fungicides;

[0190] (b) one or more strobilurin fungicides (QoI);

[0191] (c) one or more succinate dehydrogenase inhibitor (SDHI) fungicides, such as pyrazole-carboxamide fungicides;

[0192] (d) one or more triazole (azole) fungicides (DMIs);

[0193] (e) one or more morpholine fungicides

[0194] (f) A mixture of any two or more of (a) to (e).

[0195] The polyphenol-based component (1) usually, typically or even advantageously consists of a mixture of different compounds, each of which contains at least two phenolic functions.

[0196] Polyphenol-Based Component Example #3

[0197] In the noted embodiments, the polyphenol-based component includes but is not limited to natural, naturally derived or derived polyphenols. In some cases, the naturally derived polyphenol-based component (1) includes at least a portion of one or more synthetic polyphenol compounds without departing from the present invention.

[0198] In some recognized advantageous embodiments, the polyphenol-based component comprises at least one polyphenol that is not a lignin sulfonate. In some cases, without departing from the present invention, the polyphenol-based component (1) of the combination of the present invention or a composition comprising the combination comprises at least a portion of one or more lignin sulfonates.

[0199] The polyphenol-based compounds are represented by the group comprising phenolic acids, stilbenes, lignans, hydrolyzable tannins, tannic acid, lignin, flavonoids and combinations thereof. Castanea ellagitannins; extracts of water-soluble tannins; extracts of water-soluble proanthocyanidins

[0200] In some embodiments, flavonoids refer to, but are not limited to, flavones, aurones, anthocyanins, anthocyanins, flavonols, flavanols, flavanones, chalcones, isoflavones, proanthocyanidins, and combinations thereof.

[0201] In some embodiments, the polyphenol-based component is comprised of one or more extracts, each extract comprising at least one structure / source of polyphenol.

[0202] For the sake of clarity, commonly used lignin sulfonates (e.g. as dispersants) are not intended to be included in the term polyphenol-based component (1). However, incorporating lignin sulfonates and other similar known pesticide ingredients into compositions comprising the combination of the invention does not depart from the scope of the invention, as long as both the polyphenol-based component (1) and the at least one (systemic) fungicide (A) compound of component (2) are contained in the combination.

[0203] In a useful embodiment, tannins include various types of tannins, such as condensed and / or hydrolyzable tannins and / or brown algae polyphenols. It is worth noting that condensed tannins of the proanthocyanidin and / or prodelphinidin type, such as condensed tannins of maritime pine (Pinus maritimeus), Chilean pine (Araucaria araucaria), pecan (Carya nutans), spruce (Picea nigra), Douglas fir, etc.; and / or condensed tannins of the protoacacia and / or protofissertin type, such as condensed tannins of mimosa (Black wattle, Black Castanopsis, Acacia, Catechu), Anacardiaceae Axe, Red Quercus), Black Catechu, etc.; and / or hydrolyzable tannins, such as hydrolyzable tannins of chestnut (European chestnut, European chestnut), Tara spiny cassia (Caesalpinia officinalis), etc.; and / or brown algae polyphenols extracted from algae. These tannins can also be used in the form in which they have been purified by extraction with organic solvents, by processes such as acylation, methylation, ethoxylation, propoxylation, etc., and / or in the form in which they have been modified or transformed by various chemical and physical reactions, such as polymerization, oxidation or enzymatic or chemical hydrolysis, and / or by the introduction of amino groups, so that the tannins can also be in the form of sulfited, sulfonated, oxidized, acetylated, esterified, ethoxylated or propoxylated substances, or possible mixtures thereof.

[0204] In some embodiments, the polyphenolic compound of the polyphenol-based component (1) comprises castanea ellagitannin, alone or together with other natural polyphenolic compounds.

[0205] In some noted and exemplified embodiments, the polyphenolic compounds of the polyphenol-based component (1) are extracts of water-soluble tannins and proanthocyanidins.

[0206] In some embodiments, the combinations of the present invention further comprise at least one additional polyphenol-based component ingredient.

[0207] Component (3) Example #4

[0208] In some embodiments, the protectant fungicide of component (3) is selected from the group consisting of fluazinam; thiophanate-methyl; mancozeb; sulfur; folpet; captan and mixtures thereof.

[0209] In some embodiments, component (3) comprises a compound selected from the group of: copper-based compounds, alone or in combination with a protectant fungicide.

[0210] In some embodiments, component (3) comprises a compound selected from the group of: copper-based compounds, alone or in combination with a protectant fungicide.

[0211] In some embodiments, component (3) comprises protectant fungicide compounds, wherein at least one compound is present in a concentration and / or amount significantly lower than levels currently used in known combinations with fungicide (A) (sometimes referred to as systemic fungicides).

[0212] In some embodiments, component (3) consists of at least one protectant fungicide selected from the group consisting of fluazinam; thiophanate-methyl; mancozeb; sulfur; folpet; captan together with at least one copper-based compound.

[0213] In some embodiments, the protectant fungicide is fluazinam

[0214] In some embodiments, the protectant fungicide is thiophanate-methyl

[0215] In some embodiments, the protectant fungicide is a dithiocarbamate.

[0216] In some embodiments, when present, the dithiocarbamate may be, but is not limited to, any, some, or all of the following: mancozeb, zineb, propineb, and maneb.

[0217] In some embodiments, the protectant fungicide comprises mancozeb.

[0218] In some embodiments, the protectant fungicide comprises sulfur.

[0219] In some embodiments, the protectant fungicide comprises one or more phthalimide fungicides.

[0220] In some embodiments, the phthalimide fungicide is, for example, one or more of folpet, captan, and captafol.

[0221] In some embodiments, the protectant fungicide comprises folpet.

[0222] In some embodiments, the protectant fungicide comprises captan.

[0223] Copper-Based Component (3) Example #5

[0224] In some embodiments, a protectant fungicide is combined with a copper-based compound as component (3).

[0225] In some embodiments, component (3) of the combination comprises a copper-based compound, such as a copper-based fungicide and / or metallic copper, without any protectant fungicide as defined above.

[0226] In some embodiments, component (3) of the multi-component combination of the present invention comprises a copper-based compound selected from the following group: copper acetate; copper chloride; copper chlorate; copper formate; copper hexafluorosilicate; copper nitrate; copper chromate; copper sulfate pentahydrate; Bordeaux mixture; copper hydroxide; copper oxychlorosulfate (COCS); tricopper sulfate such as copper sulfate; tricopper hydroxide; hemihydrate; copper chelated (or complexed) with EDTA; copper chelated (or complexed) with amino acids; copper chelated / complexed with both EDTA and amino acids; copper glycinate; copper alanate; and any and all combinations thereof.

[0227] In some embodiments, copper-based compounds can include, but are not limited to, copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, copper oxychlorosulfate (COCS), tricopper sulfate such as copper sulfate, tricopper hydroxide, hemihydrate, copper chelated (or complexed) with EDTA; copper chelated (or complexed) with amino acids; copper chelated / complexed with both EDTA and amino acids; copper glycinate; copper alanate; or any and all combinations thereof.

[0228] In some embodiments, the copper-based compound is selected from the group consisting of copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, and any and all combinations thereof.

[0229] In some embodiments, the copper-based compound is a Bordeaux mixture.

[0230] In some embodiments, the copper-based compound is copper hydroxide.

[0231] In some embodiments, the copper-based compound is copper oxychloride.

[0232] In some embodiments, the copper-based compound is selected from the group consisting of copper sulfate pentahydrate, Bordeaux mixture, and any combination thereof.

[0233] In some prominent embodiments, the copper-based compound of component (3) includes copper complexed or chelated with, for example, EDTA, amino acids (eg, glycine, etc.).

[0234] In some particularly noteworthy embodiments, the polyphenol-based compound of component (1) is used as a mixture with the copper-based compound of component (3) prior to combination with the systemic fungicide of component (2). Some copper compounds can undergo some undesirable interactions, and thus there are particularly useful copper-based compounds (e.g., certain copper complexes, etc.) that avoid such interactions.

[0235] Improved Example #6

[0236] Therefore, in the above improved combination embodiments of the present invention, further improvements of each combination embodiment can be achieved, wherein each of the Bordeaux mixture; copper hydroxide; copper oxychloride; and copper sulfate pentahydrate; is each replaced by a copper complex or chelated copper compound.

[0237] In some noted embodiments, a further improvement of the combinations of the present invention comprising a polyphenol-based component (1) and an amount of copper complexed or chelated with, for example, EDTA, amino acids, etc., or other copper complexes as component (3) compounds is that significantly reduced amounts of the polyphenol-based component (1) can be effectively used to either or both of: enhance the fungicidal efficacy of the systemic fungicide component (2) and / or reduce or even eliminate the amount of protectant fungicides, such as fluazinam; thiophanate-methyl; dithiocarbamates, such as mancozeb, zineb, propineb, and maneb; sulfur; phthalimide fungicides, such as folpet, captan, captafol, etc., typically encountered in previous combinations with compounds comprising component (2).

[0238] In some embodiments comprising a three-component combination, a mixture of a polyphenol-based component (1) and a copper-based component (3) is provided as a single composition for combination with a separately prepared composition of component (2) comprising a (systemic) fungicide (A) of component (2) prior to application. In several embodiments, this combination is accomplished by mixing the two types of compositions into a tank mix, or alternatively, the two compositions are applied separately in any of simultaneous, concurrent, concomitant, sequential and / or consecutive / sequential applications. In some embodiments comprising a three-component combination (comprising both a copper-based fungicide as well as a protectant fungicide as component (3)), a mixture of a polyphenol-based component (1) and a copper-based compound of component (3) is provided as a single composition for combination with a separately prepared composition of a (systemic) fungicide (A) of component (2) and a protectant fungicide compound of component (3) prior to application. In several embodiments, the combination is accomplished by combining the two types of compositions into a tank mix, or alternatively, the two compositions are administered separately in any of simultaneous, concurrent, concomitant, sequential, and / or continuous / sequential administration.

[0239] As can be appreciated, mixtures of polyphenolic compounds with copper compounds can be considered as components and embodiments of the present invention, wherein the amount or concentration of the copper compound is significantly below the level required to have a fungicidal effect. As can be immediately appreciated and / or understood, when combined with the fungicide (A) of component (2), a mixture of polyphenolic compounds with a negligibly fungicidal content of copper that does not reach a therapeutic dose can effectively be considered as having only practical use as a fungicidal combination, rather than any simple commercial fungicidal product. Therefore, this combination of polyphenol-based (1) and a minimal content of copper compound (3) can be referred to as a combination of polyphenols and copper compounds, suitable for preparing the multi-component combination of the present invention, wherein it is shown to enhance the effect of the polyphenol-based component. These mixtures of polyphenolic compounds with copper compounds can effectively be provided in kit form together with a separate mixture of the fungicidally active component (2).

[0240] Without being bound by any theory, to the extent that the present invention can be viewed in one aspect as a method of enhancing the fungicidal effect of a systemic fungicide (A) as defined above by combining said fungicide with a polyphenolic compound, the minimal amount of copper used in the above examples can be viewed as enhancing the fungicidal enhancing ability of the polyphenolic compound rather than exhibiting any significant pesticidal efficacy or even directly affecting the fungicide (A) itself.

[0241] As will be appreciated, the minimal amounts of copper-based compounds included with the polyphenolic compounds in some embodiments typically have minimal or no phytotoxic effects, in stark contrast to the amounts of copper-based compounds previously used at much higher doses as fungicidally active compounds themselves or as protectants.

[0242] Fungicide Combination Example #7

[0243] In some embodiments, the combinations of the invention comprise a polyphenol-based component and a QiI fungicide.

[0244] In some embodiments, the combinations of the present invention comprise a polyphenol-based component and an azole fungicide.

[0245] In some embodiments, the combinations of the invention comprise a polyphenol-based component and a morpholine fungicide.

[0246] In some embodiments, the combinations of the invention comprise a polyphenol-based component and a SDHI fungicide.

[0247] In some embodiments, the combinations of the invention comprise a polyphenol-based component and a strobilurin fungicide.

[0248] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a QiI fungicide, and an azole fungicide.

[0249] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, and a SDHI fungicide.

[0250] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, and a strobilurin fungicide.

[0251] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, and an azole fungicide.

[0252] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a SDHI fungicide, and a strobilurin fungicide.

[0253] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, and a strobilurin fungicide.

[0254] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a QiI fungicide, an azole fungicide, and a protectant fungicide.

[0255] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, a SDHI, and a protectant fungicide.

[0256] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, a strobilurin fungicide, and a protectant fungicide.

[0257] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, an azole fungicide, and a protectant fungicide.

[0258] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a SDHI fungicide, a strobilurin fungicide, and a protectant fungicide.

[0259] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, a strobilurin fungicide, and a protectant fungicide.

[0260] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a QiI fungicide, and a protectant fungicide.

[0261] In some embodiments, the combinations of the invention comprise a polyphenol-based component, an azole fungicide, and a protectant fungicide.

[0262] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a morpholine fungicide, and a protectant fungicide.

[0263] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a SDHI fungicide, and a protectant fungicide.

[0264] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a strobilurin fungicide, and a protectant fungicide.

[0265] In some embodiments, the combinations of the present invention comprise a polyphenol-based component, a copper-based compound, and a QiI fungicide.

[0266] In some embodiments, the combinations of the present invention comprise a polyphenol-based component, a copper-based compound, and an azole fungicide.

[0267] In some embodiments, the combination of the present invention comprises a polyphenol-based component, a copper-based compound, and a morpholine fungicide.

[0268] In some embodiments, the combinations of the present invention comprise a polyphenol-based component, a copper-based compound, and a SDHI fungicide.

[0269] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, and a strobilurin fungicide.

[0270] In some embodiments, the combinations of the present invention comprise a polyphenol-based component, a copper-based compound, a QiI fungicide, and an azole fungicide.

[0271] In some embodiments, the combinations of the present invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, and a SDHI fungicide.

[0272] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, and a strobilurin fungicide.

[0273] In some embodiments, the combinations of the present invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, and an azole fungicide.

[0274] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a SDHI fungicide, and a strobilurin fungicide.

[0275] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, and a strobilurin fungicide.

[0276] In some embodiments, the combinations of the present invention comprise a polyphenol-based component, a copper-based compound, a QiI fungicide, an azole fungicide, and a protectant fungicide.

[0277] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, a SDHI, and a protectant fungicide.

[0278] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, a strobilurin fungicide, and a protectant fungicide.

[0279] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, an azole fungicide, and a protectant fungicide.

[0280] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a SDHI fungicide, a strobilurin fungicide, and a protectant fungicide.

[0281] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, a strobilurin fungicide, and a protectant fungicide.

[0282] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a QiI fungicide, and a protectant fungicide.

[0283] In some embodiments, the combinations of the present invention comprise a polyphenol-based component, a copper-based compound, an azole fungicide, and a protectant fungicide.

[0284] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a morpholine fungicide, and a protectant fungicide.

[0285] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a SDHI fungicide, and a protectant fungicide.

[0286] In some embodiments, the combinations of the invention comprise a polyphenol-based component, a copper-based compound, a strobilurin fungicide, and a protectant fungicide.

[0287] In some embodiments, azole fungicides may include, but are not limited to, azaconazole, bifenthrin, bromoconazole, cyproconazole, difenoconazole, diniconazole, fluepiconazole, eticonazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imipenem, methiconazole, metconazole, myclobutanil, penconazole, propiconazole, silyfloxacin, tebuconazole, tetraconazole, triadimefon, triadimenol, triathione, prothioconazole, clofoconazole, and any mixture thereof.

[0288] In some embodiments, the azole fungicide is tebuconazole.

[0289] In some embodiments, the azole fungicide is prothioconazole.

[0290] In some embodiments, the azole fungicide is cyproconazole.

[0291] In some embodiments, the azole fungicide is difenoconazole

[0292] In some embodiments, the strobilurin fungicide can include, but is not limited to, azoxystrobin, syringystrobin, enoxastrobin, flutoxifen, picoxystrobin, pyraclostrobin, tosoxystrobin, pyraclostrobin, pyraclostrobin, pyraclostrobin, chlorpyrifos, kresoxim-methyl, trifloxystrobin, orysastrobin, enoxastrobin, fenoxystrobin, orysastrobin, tetrazobactam, fluoxastrobin, and any mixtures thereof.

[0293] In some embodiments, the strobilurin fungicide is selected from the group consisting of picoxystrobin, trifloxystrobin, azoxystrobin, pyraclostrobin, fenoxystrobin, tetrazobactam, toluenestrobin, and any combination thereof.

[0294] In some embodiments, the strobilurin fungicide is picoxystrobin.

[0295] In some embodiments, the strobilurin fungicide is azoxystrobin.

[0296] In some embodiments, the SDHI fungicide may include, but is not limited to, penthiopyrad, boscalid, flutolanil, fluopyram, indopyram, fluopyram, flutopyram, benzovintriazole, bixafen, Adepidyn, and any mixtures thereof.

[0297] In some embodiments, the SDHI fungicide is selected from the group consisting of bixafen; fluopyram; fluoxapyram; indoppyram; benzovintriazole; fluopyram, and any mixtures thereof.

[0298] In some embodiments, the SDHI fungicide is pentocyclam.

[0299] In some embodiments, QiI fungicides may include, but are not limited to, cyazofamid, indazolesulfamide, and fenpicoxamid.

[0300] In some embodiments, QiI is pyridobactamide.

[0301] In some embodiments, the morpholine may include, but is not limited to, 4-dodecyl-2,6-dimethylmorpholine (aldimorph), benzamorf, morpholine, dimethomorph, fenmorph, flumorph, tridemorph, flumorph, dodecamorph, spiroxafil, fenpropimorph, and fenpropidin.

[0302] In some embodiments, the protectant fungicide includes any one of the following: mancozeb; sulfur; folpet; captan, fluazinam; thiophanate-methyl; dithiocarbamates; mancozeb; propineb; maneb.

[0303] In some embodiments, the protectant fungicide comprises mancozeb.

[0304] In some embodiments, the protectant fungicide comprises a sulfur compound.

[0305] In some embodiments, the protectant fungicide comprises one or more phthalimide fungicides.

[0306] In some embodiments, the phthalimide fungicide is, for example, one or more of folpet, captan, and captafol.

[0307] In some embodiments, the protectant fungicide comprises folpet.

[0308] In some embodiments, the protectant fungicide comprises captan.

[0309] Specific combination embodiment

[0310] The following examples, including the illustrative Table 1 of exemplary combinations, are used to illustrate the breadth of the combinatorial scope of the present invention. The list of the following examples is not intended to be comprehensive in any way, but rather to provide an understanding of the scope of the types of combinations considered. Based on these enumerated examples, those skilled in the art will immediately recognize and appreciate variations that will be within the scope of the present disclosure, even if they are not specifically recorded herein.

[0311] The presence or absence of specific combination embodiments or forms of any ingredients used in the components of the combination embodiments listed below does not in any way indicate that these are preferred embodiments, or even that they are particularly noteworthy, unless so indicated.

[0312] For example, in all of the following listed and tabulated embodiments of the inventive combinations wherein component (3) comprises a copper-based compound, the corresponding combinations wherein the copper-based compound included in each listed embodiment is replaced with one or more copper complexes, such as copper-amino acid complexes, such as copper glycinate and / or copper chelated with an agent like EDTA, are believed to be particularly noteworthy and generally more useful than the listed copper-based compounds of the disclosed embodiments.

[0313] In advantageous forms of the listed and enumerated embodiments disclosed and suggested herein, the polyphenol-based component comprises a combined extract of natural water-soluble tannins and proanthocyanidins as a source of polyphenols, and thus the polyphenol-based compounds herein, etc., inventively used in the inventive combinations, compositions and methods disclosed herein, are typically mixtures of several generally naturally derived or derived water-soluble tannins and proanthocyanidins. Notably, the further inclusion of synthetic polyphenol-based compounds has not been found to adversely affect the benefits already achieved with these natural tannins and proanthocyanidins, and thus, the inclusion of synthetic polyphenol-based compounds in the combinations of the present invention does not depart from the present invention, and thus does not remove the combinations comprising them from the scope of protection sought.

[0314] Proanthocyanidins are a class of polyphenols found in many plants. Chemically, they are oligomeric flavonoids. More complex polyphenols with the same polymer structural unit form the group of tannins.

[0315] Tannins are complex chemicals derived from phenolic acids found in a variety of plant species. They are typically large polyphenolic molecules that readily bind to proteins, cellulose, starch, and minerals. Tannins are commonly found in bark, wood, leaves, buds, stems, fruits, seeds, roots, and plant galls. Tannins are thought to help protect individual plant species. For example, tannins stored in bark may protect trees to some extent from infection by certain bacteria or fungi.

[0316] Without being bound by any theory, it is believed that while the polyphenol-based compounds herein inventively used in the combinations, compositions, methods, etc. of the present invention generally possess a certain degree of protective or fungicidal activity, the improved degree of pesticidal or fungicidal enhanced efficacy of the combinations of the present invention cannot be simply or purely explained by the inherent protective properties of the polyphenol-based compounds used.

[0317] Generally, the polyphenol-based compound as component (1) may be used in a solid or liquid form.

[0318] For illustrative purposes, typical embodiments of liquid forms of polyphenol-based components include liquids comprising any of 7.5%, 10%, 12.5%, 15%, 17.5%, 20%, 22.5%, 25%, 27.5%, 30%, 32.5%, 35%, 37.5%, 40%, 42.5% or 45% of a mixture of several, typically naturally derived or derived, water-soluble tannins and proanthocyanidins.

[0319] Obviously, using compositions comprising different numerical percentage contents of polyphenol-based compounds as component (1) (ie in diluted or concentrated form) does not in any way depart from the scope of the present invention, but these above exemplified percentages make the calculation of the component ratios easier to calculate.

[0320] In the embodiments listed, tabulated and / or suggested herein, the content of the polyphenol-based component (1) is generally between about 10 g / ha and about 350 g / ha, and in some common cases, the content of the polyphenol-based component (1) is between about 40 g / ha and about 90 g / ha, for example but not limited to between 43.75 g / ha and 87.5 g / ha.

[0321] For the sake of clarity, when discussing the content of an ingredient for agricultural application in an agricultural composition, particularly in concentrated form, it is often convenient to refer to the intended application rate. For example, a content of an ingredient described as 10 g / ha in a concentrate designed to be diluted before use should be understood as the amount of that ingredient that will be applied at 10 g / ha when diluted and applied from a typical tank mix dilution and liquid spray rate (e.g., 150 L / ha). When the content of an ingredient in an agricultural composition is defined by g / ha, it is clear that the concentrate has the same content even if the final dilution and / or spray rate changes, however this is a recognized description of the content of such an ingredient in agriculture.

[0322] Specific combination embodiment #8

[0323] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, tebuconazole, and Bordeaux mixture.

[0324] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, tebuconazole, and fluazinam.

[0325] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, tebuconazole, and folpet.

[0326] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, tebuconazole, and sulfur.

[0327] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, prothioconazole, and mancozeb.

[0328] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, prothioconazole, and cupric oxychloride.

[0329] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, prothioconazole, and copper hydroxide.

[0330] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, prothioconazole, and Bordeaux mixture.

[0331] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, prothioconazole, and fluazinam.

[0332] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, prothioconazole, and captan.

[0333] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, prothioconazole, and folpet.

[0334] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, prothioconazole, and sulfur.

[0335] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, tebuconazole, and mancozeb.

[0336] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, tebuconazole, and cupric oxychloride.

[0337] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, tebuconazole, and copper hydroxide.

[0338] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, tebuconazole, and Bordeaux mixture.

[0339] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabdo, tebuconazole, and fluazinam.

[0340] In some embodiments, the combination comprises a polyphenol-based component, fluopyraclostrobin, tebuconazole, and thiophanate-methyl.

[0341] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, tebuconazole, and captan.

[0342] In some embodiments, the combination comprises a polyphenol-based component, fluopicolide, tebuconazole, and folpet.

[0343] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, tebuconazole, and sulfur.

[0344] In some embodiments, the combination comprises a polyphenol-based component, fluopyrab, prothioconazole, and mancozeb.

[0345] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, prothioconazole, and cupric oxychloride.

[0346] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, prothioconazole, and copper hydroxide.

[0347] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabdo, prothioconazole, and a Bordeaux mixture.

[0348] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabdo, prothioconazole, and fluazinam.

[0349] In some embodiments, the combination comprises a polyphenol-based component, fluopyraclostrobin, prothioconazole, and thiophanate-methyl.

[0350] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabdo, prothioconazole, and captan.

[0351] In some embodiments, the combination comprises a polyphenol-based component, fluopyrab, prothioconazole, and folpet.

[0352] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, prothioconazole, and sulfur.

[0353] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and mancozeb.

[0354] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and cupric oxychloride.

[0355] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and copper hydroxide.

[0356] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and Bordeaux mixture.

[0357] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and fluazinam.

[0358] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and thiophanate-methyl.

[0359] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and captan.

[0360] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and folpet.

[0361] In some embodiments, the combination comprises a polyphenol-based component, picoxystrobin, fenpropidin, and sulfur.

[0362] In some embodiments, the combination comprises a polyphenol-based component, fluopyram, fenpropidin, and mancozeb.

[0363] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, fenpropidin, and cupric oxychloride.

[0364] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, fenpropidin, and copper hydroxide.

[0365] In some embodiments, the combination comprises a polyphenol-based component, fluopyram, fenpropidin, and Bordeaux mixture.

[0366] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabdo, fenpropidin, and fluazinam.

[0367] In some embodiments, the combination comprises a polyphenol-based component, fenpropidin, fluopicolide, and thiophanate-methyl.

[0368] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabdo, fenpropidin, and captan.

[0369] In some embodiments, the combination comprises a polyphenol-based component, fluopicolide, fenpropidin, and folpet.

[0370] In some embodiments, the combination comprises a polyphenol-based component, fluopyrabamide, fenpropidin, and sulfur.

[0371] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and mancozeb.

[0372] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and cupric oxychloride.

[0373] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and copper hydroxide.

[0374] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and Bordeaux mixture.

[0375] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and fluazinam.

[0376] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and thiophanate-methyl.

[0377] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and captan.

[0378] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and folpet.

[0379] In some embodiments, the combination comprises a polyphenol-based component, prothioconazole, fenpropidin, and sulfur.

[0380] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and mancozeb.

[0381] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and cupric oxychloride.

[0382] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and copper hydroxide.

[0383] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and Bordeaux mixture.

[0384] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and fluazinam.

[0385] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and thiophanate-methyl.

[0386] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and captan.

[0387] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and folpet.

[0388] In some embodiments, the combination comprises a polyphenol-based component, tebuconazole, fenpropidin, and sulfur.

[0389] In some embodiments, the combination comprises a polyphenol-based component, azoxystrobin, difenoconazole, and thiophanate-methyl.

[0390] In some embodiments, the combination comprises a polyphenol-based component, cyproconazole, mancozeb, and tetrazopyridamole.

[0391] In some embodiments, the combination comprises a polyphenol-based component, cyproconazole, mancozeb, and tetrazopyridamole.

[0392] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and tetrazopyrazone.

[0393] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and picoxystrobin.

[0394] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and fluopicolide.

[0395] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and azoxystrobin.

[0396] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and trifloxystrobin.

[0397] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and pyraclostrobin.

[0398] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and fenoxam.

[0399] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and bixafen.

[0400] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and indopyraclostrobin.

[0401] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and fluinoxam.

[0402] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and benzotriazole.

[0403] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, cyproconazole, and pentoquinol.

[0404] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and tetrazopyridamole.

[0405] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and picoxystrobin.

[0406] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and fluopicolide.

[0407] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and azoxystrobin.

[0408] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and trifloxystrobin.

[0409] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and pyraclostrobin.

[0410] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and fenoxystrobin.

[0411] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and bixafen.

[0412] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and indopyraclostrobin.

[0413] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and flufenoxam.

[0414] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and benzotriazole.

[0415] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and pentocyclamide.

[0416] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and pyridoxamide.

[0417] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and tetracycline.

[0418] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and picoxystrobin.

[0419] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluopicolide, and trifloxystrobin.

[0420] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and azoxystrobin.

[0421] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and trifloxystrobin.

[0422] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and pyraclostrobin.

[0423] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and fenoxystrobin.

[0424] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and bixafen.

[0425] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and indopyraclostrobin.

[0426] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluopicolide, and flufenoxam.

[0427] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluazifop, and benzotriazole.

[0428] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluopicolide, and pentocyclamide.

[0429] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and pyridamole.

[0430] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, difenoconazole, and pyridoxamide.

[0431] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and tetracycline.

[0432] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and picoxystrobin.

[0433] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluopicolide, and trifloxystrobin.

[0434] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and azoxystrobin.

[0435] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and trifloxystrobin.

[0436] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and pyraclostrobin.

[0437] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and fenoxystrobin.

[0438] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and bixafen.

[0439] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluazifop-dopamide, and indopamide

[0440] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluopicolide, and flufenoxam.

[0441] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluazifop, and benzotriazole.

[0442] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, fluopicolide, and pentocyclamide.

[0443] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, mefenacet, and pyridamole.

[0444] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and pyridobactamide.

[0445] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and tetrazopyrazone.

[0446] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and picoxystrobin.

[0447] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and fluopyrab.

[0448] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and azoxystrobin.

[0449] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and trifloxystrobin.

[0450] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and pyraclostrobin.

[0451] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and fenoxystrobin.

[0452] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and bixafen.

[0453] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and indopyraclostrobin.

[0454] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and fluinoxam.

[0455] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and benzotriazole.

[0456] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and fluopicolide.

[0457] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and pyridobactamide.

[0458] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and pyridoxamide.

[0459] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and tetrazopyrazone.

[0460] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and fluopicolide.

[0461] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and fluopyrab.

[0462] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and azoxystrobin.

[0463] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and trifloxystrobin.

[0464] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and pyraclostrobin.

[0465] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and fenoxam.

[0466] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and bixafen.

[0467] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and indopyraclostrobin.

[0468] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and fluinoxam.

[0469] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and benzotriazole.

[0470] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and fluopicolide.

[0471] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, prothioconazole, and pyridobactamide.

[0472] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and toluenestrobin.

[0473] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and tetrazoclostrobin.

[0474] In some embodiments, the combination comprises a polyphenol-based component, mancozeb, tebuconazole, and pentoquinol.

[0475] In some embodiments, the combination comprises a polyphenol-based component, cyproconazole, a copper-based compound, and tetrazopyrazone.

[0476] In some embodiments, the combination comprises a polyphenol-based component, cyproconazole, a copper-based compound, and tetrazopyrazone.

[0477] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and tetrazopyrazone.

[0478] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and picoxystrobin.

[0479] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and fluopicolide.

[0480] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and azoxystrobin.

[0481] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and trifloxystrobin.

[0482] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and pyraclostrobin.

[0483] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and fenoxystrobin.

[0484] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and bixafen.

[0485] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and indopyraclostrobin.

[0486] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and fluinoxam.

[0487] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and benzovintriazole.

[0488] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, cyproconazole, and pentoquinol.

[0489] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and tetrazopyrazone.

[0490] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and picoxystrobin.

[0491] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and fluopicolide.

[0492] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and azoxystrobin.

[0493] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and trifloxystrobin.

[0494] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and pyraclostrobin.

[0495] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and fenoxystrobin.

[0496] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and bixafen.

[0497] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and indopyraclostrobin.

[0498] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and flufenoxam.

[0499] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and benzotriazole.

[0500] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and pentocyclamide.

[0501] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and pyridoxamide.

[0502] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and tetrazopyrazone.

[0503] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and picoxystrobin.

[0504] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and fluopicolide.

[0505] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and azoxystrobin.

[0506] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and trifloxystrobin.

[0507] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and pyraclostrobin.

[0508] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenacet, and fenoxystrobin.

[0509] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenacet, and bixafen.

[0510] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenacet, and indopamidol.

[0511] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and flufenoxam.

[0512] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, fluopicolide, and benzotriazole.

[0513] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenacet, and pentopyralid.

[0514] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and pyraclostrobin.

[0515] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, difenoconazole, and pyridoxamide.

[0516] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and tetrazopyrazone.

[0517] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and picoxystrobin.

[0518] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and fluopicolide.

[0519] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and azoxystrobin.

[0520] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and trifloxystrobin.

[0521] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and pyraclostrobin.

[0522] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenacet, and fenoxystrobin.

[0523] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenacet, and bixafen.

[0524] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenacet, and indopamidol.

[0525] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and flufenoxam.

[0526] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, fluopicolide, and benzotriazole.

[0527] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenacet, and pentopyralid.

[0528] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, mefenamic acid oxadiazole, and pyraclostrobin.

[0529] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and pyridamole.

[0530] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and tetrazopyrazone.

[0531] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and picoxystrobin.

[0532] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and fluopyrabdo.

[0533] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and azoxystrobin.

[0534] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and trifloxystrobin.

[0535] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and pyraclostrobin.

[0536] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and fenoxystrobin.

[0537] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and bixafen.

[0538] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and indopyraclostrobin.

[0539] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and fluinoxam.

[0540] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and benzovindiflupyr.

[0541] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and trifloxystrobin.

[0542] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and pyridamole.

[0543] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and picoxystrobin.

[0544] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and pyridobactamide.

[0545] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and tetrazopyrazone.

[0546] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and picoxystrobin.

[0547] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and fluopicolide.

[0548] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and fluopyrabdo.

[0549] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and azoxystrobin.

[0550] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and trifloxystrobin.

[0551] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and pyraclostrobin.

[0552] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and fenoxystrobin.

[0553] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and bixafen.

[0554] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and indopyraclostrobin.

[0555] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and fluinoxam.

[0556] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and benzovindiflupyr.

[0557] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and trifloxystrobin.

[0558] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, prothioconazole, and pyridamole.

[0559] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and toluenestrobin.

[0560] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and tetrazopyrazone.

[0561] In some embodiments, the combination comprises a polyphenol-based component, a copper-based fungicide, tebuconazole, and pentoquinol.

[0562] As an extended description of the possible range of combinations within the scope of the present invention, Tables 1 and 2 below list some (although obviously not all) combinations that the inventors specifically and individually consider. Obviously, other combinations cannot be excluded from the scope simply because they are not in the following illustrative tables. Each row in the table represents each independent embodiment of the present invention. Although Table 1 provides some illustrative specific combination embodiments (each row is a separate and independently claimed embodiment), Table 2 shows a scheme allowing multiple selections of the compound for each embodiment. In each table, a blank cell indicates that the component category does not exist in this specific embodiment.

[0563] Table 1

[0564] Illustrative Example #9

[0565]

[0566]

[0567]

[0568]

[0569]

[0570]

[0571]

[0572]

[0573]

[0574]

[0575]

[0576]

[0577]

[0578]

[0579]

[0580]

[0581]

[0582]

[0583]

[0584]

[0585]

[0586]

[0587]

[0588]

[0589]

[0590]

[0591]

[0592]

[0593]

[0594]

[0595]

[0596]

[0597]

[0598]

[0599]

[0600]

[0601]

[0602]

[0603]

[0604]

[0605]

[0606]

[0607]

[0608]

[0609]

[0610]

[0611]

[0612]

[0613]

[0614]

[0615]

[0616]

[0617]

[0618]

[0619]

[0620]

[0621]

[0622]

[0623]

[0624]

[0625]

[0626]

[0627]

[0628]

[0629]

[0630]

[0631]

[0632]

[0633]

[0634]

[0635]

[0636]

[0637]

[0638]

[0639]

[0640]

[0641]

[0642]

[0643]

[0644]

[0645]

[0646]

[0647]

[0648]

[0649]

[0650]

[0651]

[0652]

[0653] Illustrative Table 2 Protocol Example #10

[0654] In the following scheme showing four choices of multi-component combinations as shown in Table 2, each row represents several possible individual embodiments, wherein each case of the protectant is at least one of the following or any mixture: mancozeb, thiophanate-methyl or fluazinam; each case of the azole is at least one of the following or any mixture: cyproconazole, difenoconazole, flutriafol, flutoconazole, prothioconazole, tebuconazole, tetrafluconazole, each case of the strobilurin is at least one of the following or any mixture: azoxystrobin, toluenestrobin, fenoxystrobin, tetrazobactam, picoxystrobin, pyraclostrobin, trifloxystrobin; each case of the SDHI is at least one of the following or any mixture: fluopicolide, benzovintriazole, bixafen, flutoxapyrad, fluopicolide, indopyraclostrobin; and each case of the morpholine is at least one of the following or any mixture: fenpropidin or fenpropimorph

[0655] Table 2 Four options

[0656]

[0657] Option #1, without protectant

[0658] x x x x x x x x x x x x x x x x x x x x X x x x

[0659] Option #2, contains neither copper nor protective agent

[0660] x x x x x x x x x x x x x x x x x x

[0661] Option #3, Contains both protectant and copper

[0662] x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x

[0663] Option #4, Contains a Protectant but No Copper

[0664] x x x x x x x x x x x x x x x x x x x x x x x x

[0665] Dosage Example #11

[0666] In some embodiments, the combinations of the invention comprise between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); and a strobilurin fungicide and an azole fungicide as component (2).

[0667] In some embodiments, the combinations of the invention comprise between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); between about 40 g / ha and 200 g / ha of a strobilurin fungicide selected from the group consisting of azoxystrobin; syringosterone; enoxastrobin; flutoxifen; picoxystrobin; pyraclostrobin; toluenestrobin; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; orysastrobin; enoxastrobin; fenoxystrobin; orysastrobin; tetrazopyrad; and fluoxastrobin; and any mixtures thereof, in combination with at least one azole fungicide, as component (2).

[0668] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from the group consisting of azoxystrobin; syringystrobin; enoxastrobin; flutoxifen; picoxystrobin; pyraclostrobin; toluocysteine; pyraclostrobin; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; doxystrobin; enoxastrobin; oxazolidinone; tetrazobactam; and fluopyram. Ester; and any mixture thereof, in combination with at least one azole fungicide selected from the group consisting of azaconazole; bifenthrin; bromoconazole; cyproconazole; difenoconazole; diniconazole; fluepiconazole; eticonazole; nitrobenzene; fluquinconazole; flusilazole; flutriafol; hexaconazole; imipenem; picroconazole; metconazole; myclobutanil, penconazole, propiconazole, silyconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, trithionazole, prothioconazole, clofoconazole, and any mixture thereof.

[0669] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from the group consisting of azoxystrobin; syringosterone; enoxastrobin; flutoxifen; picoxystrobin; pyraclostrobin; tolystrobin; pyraclostrobin; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; doxystrobin; enoxastrobin; fenoxystrobin; tetracycline; fluoxastrobin; and any strobilurin mixture thereof, in combination with at least one azole fungicide selected from the group consisting of azaconazole; bifenthrin; bromoconazole; 15 g / ha a-80g / ha cyproconazole; 30g / ha-100g / ha difenoconazole; diniconazole; fluquinconazole; ethoconazole; cyproconazole; 50g / ha-150g / ha fluquinconazole; flusilazole; flutriafol; hexaconazole; imipenem; cyproconazole; metconazole; myclobutanil, penconazole, propiconazole, silafluazole, 40g / ha-150g / ha tebuconazole, 40g / ha-100g / ha tetrafluconazole, triadimefon, triadimenol, triclopyralid, 40g / ha-120g / ha prothioconazole, 50g / ha-150g / ha clofoconazole, and any mixture of azole fungicides thereof.

[0670] In some embodiments, the combination of the invention comprises between about 40 g / ha and about 90 g / ha, sometimes between about 43.75 g / ha and 87.5 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from 40 g ai / ha-200 g ai. / ha picoxystrobin, 50 g ai / ha-150 g ai / ha picoxystrobin, about 60 g ai / ha picoxystrobin, 60 g / ha-70 g / ha picoxystrobin, and typically about 65 g / ha picoxystrobin; in combination with at least one azole fungicide selected from

[0671] About 40g / ha-150g / ha tebuconazole;

[0672] About 75 g / ha to about 110 g ai / ha tebuconazole;

[0673] About 80g / ha tebuconazole;

[0674] 75g / ha-110g / ha tebuconazole;

[0675] About 80g / ha tebuconazole;

[0676] 40 g ai / ha to about 120 g ai / ha prothioconazole;

[0677] 60g / ha-80g / ha prothioconazole;

[0678] About 70g / ha of prothioconazole;

[0679] About 63g / ha of prothioconazole; and

[0680] Its azole fungicide mixture.

[0681] In some embodiments, the combination of the invention comprises between about 10 g / ha and 350 g / ha, typically about 40 g / ha-90 g / ha, usually 43.75 g / ha-87.5 g / ha of a polyphenol-based component (1); and, as component (2), an azole fungicide in combination with an SDHI fungicide selected from the group consisting of penthiopyrad; boscalid; flutolanil; fluopyram; fluopyram; fluopyram; fluinoxadone; bixafen; fluopyram; indopyram; benzovinflupyram (fluopyram) and any SDHI fungicide combination thereof.

[0682] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); a combination of a strobilurin fungicide and an azole fungicide as component (2); and a protectant fungicide selected from the group consisting of fluazinam; thiophanate-methyl; mancozeb; sulfur; folpet; maneb; metiram; polyurethanes; propineb; zineb, captan, and mixtures thereof as component (3).

[0683] In some embodiments, the combinations of the invention comprise between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); between about 40 g / ha and 200 g / ha of a strobilurin fungicide selected from the group consisting of azoxystrobin; syringosterone; enoxastrobin; flutoxifen; picoxystrobin; pyraclostrobin; tolystrobin; pyraclostrobin; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; doxystrobin; enoxastrobin; fenoxystrobin; orysastrobin; tetrazopyrazone; and fluoxastrobin; and any mixtures thereof, in combination with at least one azole fungicide as component (2); and as component (3) a protectant fungicide selected from the group consisting of fluazinam; thiophanate-methyl; mancozeb; sulphur; folpet; maneb; metiram; polyurethanes; propineb; maneb, captan and mixtures thereof.

[0684] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from the group consisting of azoxystrobin; syringystrobin; enoxastrobin; flutoxifen; picoxystrobin; pyraclostrobin; toluenestrobin; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; doxystrobin; enoxastrobin; fenoxystrobin; oxadiazon; tetrazopyrad; and fluoxastrobin; and any mixture thereof, in combination with at least one azole fungicide selected from the group consisting of azaconazole; bifenthrin ; bromoconazole; cyproconazole; difenoconazole; diniconazole; fluepiconazole; eticonazole; nitrobenazole; fluquinconazole; flusilazole; flutriafol; hexaconazole; imipenem; picroconazole; metconazole; myclobutanil, penconazole, propiconazole, silafluazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triclosan, prothioconazole, clofluconazole, and any mixture thereof; and a protectant fungicide selected from the following: fluazinam; chlorothalonil; (EBDC) mancozeb; sulfur; folpet; maneb; metiram; polyurethane; propineb; maneb, captan and mixtures thereof as component (3).

[0685] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from the group consisting of azoxystrobin; syringosterone; enoxastrobin; flutoxifen; picoxystrobin; pyraclostrobin; toluenestrobin; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; etherstrobin; enoxastrobin; fenoxystrobin; oxadiazon; tetrazopyrazone; fluoxastrobin; and any strobilurin mixture thereof, in combination with at least one azole fungicide selected from the group consisting of azaconazole; bifenthrin; bromoconazole; 15 g / ha-80 g / ha cyproconazole; 30 g / ha-100 g / ha difenoconazole; diniconazole; flutoxifen; azole; ethoconazole; fenbuconazole; 50g / ha-150g / ha fluquinconazole; flusilazole; flutriafol; hexaconazole; imipenem; picroconazole; metconazole; myclobutanil, penconazole, propiconazole, silyconazole, 40g / ha-150g / ha tebuconazole, 40g / ha-100g / ha tetrafluconazole, triadimefon, triadimenol, triclosan, 40g / ha-120g / ha prothioconazole, 50g / ha-150g / ha clofoconazole, and any azole fungicide mixtures thereof; and a protectant fungicide selected from the following: fluazinam; chlorothalonil; (EBDC) mancozeb; sulfur; folpet; maneb; methanamide; polyurethane; propineb; maneb, captan and mixtures thereof as component (3).

[0686] In some embodiments, the combination of the invention comprises between about 40 g / ha and about 90 g / ha, typically between about 43.75 g / ha and 87.5 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from,

[0687] i.40g ai / ha-200g ai / ha picoxystrobin,

[0688] ii. 50 g ai / ha - 150 g ai / ha picoxystrobin

[0689] iii. About 60g ai / ha picoxystrobin

[0690] iv.60g / ha-70g / ha picoxystrobin,

[0691] v. About 65g / ha of picoxystrobin;

[0692] It is combined with at least one azole fungicide selected from the following

[0693] i. about 75g / ha-110g / ha tebuconazole;

[0694] ii. about 80 g / ha tebuconazole; and

[0695] iii.60g / ha-80g / ha prothioconazole,

[0696] iv. about 63 g / ha of prothioconazole; and

[0697] v. Azole fungicide mixtures thereof,

[0698] Typically combined with a protectant fungicide selected from

[0699] a. About 200g / ha-500g / ha fluazinam;

[0700] b. about 300 g / ha fluazinam;

[0701] c. About 400g / ha-1200g / ha chlorothalonil;

[0702] d. About 400g / ha-1000g / ha chlorothalonil;

[0703] e. About 700g / ha chlorothalonil;

[0704] f. (EBDC) 400g / ha-1500g / ha mancozeb;

[0705] g.400g / ha-900g / ha mancozeb;

[0706] h. about 700g / ha mancozeb; and

[0707] i. Its protectant fungicide mixture

[0708] As component (3).

[0709] In some embodiments, the combination of the invention comprises between about 10 g / ha and 350 g / ha, typically about 40 g / ha-90 g / ha (e.g. 43.8-87.5 g / ha) of a polyphenol-based component (1); and an azole fungicide in combination with a SDHI fungicide selected from the group consisting of: penthiopyrad; boscalid; flutolanil; fluopyram; fluopyram; fluoxapyram; fluopyram; fluoxazolidinone; bixafen; fluopyram; indopyram; benzovintriazole (fluazole) The invention also provides a composition comprising at least one SDHI fungicide selected from the group consisting of: about 200 g / ha-500 g / ha, typically about 300 g / ha fluazinam; about 400 g / ha-1200 g / ha, typically about 700 g / ha chlorothalonil; (EBDC) about 400 g / ha-1500 g / ha, typically about 700 g / ha mancozeb; and a protectant fungicide mixture thereof as component (3).

[0710] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); a combination of a strobilurin fungicide and an azole fungicide as component (2); and a copper-based compound selected from the group consisting of copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, copper oxychlorosulfate (COCS), tricopper sulfate such as copper sulfate, tricopper hydroxide, hemihydrate, copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with an amino acid; copper glycinate; copper alanate; or any and all combinations thereof, as component (3).

[0711] In some embodiments, the combinations of the invention comprise between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); between about 40 g / ha and 200 g / ha of a strobilurin fungicide selected from the group consisting of azoxystrobin; syringosterone; enoxastrobin; flutoxifen; picoxystrobin; pyraclostrobin; toluenestrobin; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; orysastrobin; enoxastrobin; fenoxystrobin; orysastrobin; tetrazopyrad; and fluoxastrobin; and any mixtures thereof, in combination as component (2) with at least one azole fungicide; and about 1 g / ha to 350 g / ha and preferably 5 g / ha to 50 g / ha of metallic copper in the form of a copper-based compound selected from copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, copper oxychlorosulfate (COCS), tricopper sulfate such as copper sulfate, tricopper hydroxide, hemihydrate, copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with amino acids; copper glycinate; copper alanate; or any and all combinations thereof, as component (3).

[0712] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from the group consisting of azoxystrobin; syringosterone; enoxastrobin; flutoxin; picoxystrobin; pyraclostrobin; tolystrobin; pyraclostrobin; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; etherstrobin; enoxastrobin; fenoxystrobin; oxadiazine; tetrazobactam; and fluoxastrobin; and any mixture thereof, in combination with at least one azole fungicide selected from the group consisting of azaconazole; bifenthrin; bromoconazole; cyproconazole; difenoconazole; diniconazole; epoxiconazole; eticonazole; fenbuconazole; fluquinconazole; flusilazole; flutriafol; hexaconazole; imipenem; picroconazole; metconazole; myclobutanil, penconazole, propiconazole, silyconazole, tebuconazole, tetrafluconazole, triadimefon, triadimenol, trithionazole, prothioconazole, clofoconazole, and any mixture of azoles thereof; and about 1 g / ha-350 g / ha and preferably 5 g / ha-50 g / ha of metallic copper in the form of a copper-based compound selected from copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, copper oxychlorosulfate (COCS), tricopper sulfate such as copper sulfate, tricopper hydroxide, hemihydrate, copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with an amino acid; copper glycinate; copper alanate; or any and all combinations thereof, as component (3).

[0713] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from the group consisting of: azoxystrobin; syringystrobin; enoxastrobin; flutoxifen; picoxystrobin; pyraclostrobin; toluocysteine; pyraclostrobin; pyraclostrobin; chlorpyrifos; kresoxim-methyl; trifloxystrobin; dapoxetine; oxazolidinone; oxazolidinone; tetrazobactam; flutoxifen; oxazolidinone; oxazolidinone; oxazolidinone; oxazolidinone; oxazolidinone; oxazolidinone; oxazolidinone Ester; and any strobilurin mixture thereof, in combination with at least one azole fungicide selected from the group consisting of azaconazole; bifenthrin; bromoconazole; 15 g / ha-80 g / ha cyproconazole; 30 g / ha-100 g / ha difenoconazole; diniconazole; fluquinconazole; ethiconazole; nitrobenzazole; 50 g / ha-150 g / ha fluquinconazole; flusilazole; flutriafol; hexaconazole; imipenem; picroconazole; metconazole; myclobutanil, penconazole, propiconazole Cyproconazole, silyconazole, 40 g / ha-150 g / ha tebuconazole, 40 g / ha-100 g / ha tetraconazole, triadimefon, triadimenol, trithionazole, 40 g / ha-120 g / ha prothioconazole, 50 g / ha-150 g / ha clofoconazole, and any azole fungicide mixtures thereof with about 1 g / ha-350 g / ha and preferably 5 g / ha-50 g / ha of metallic copper in the form of copper-based compounds , the copper-based compound is selected from copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, copper oxychlorosulfate (COCS), tricopper sulfate such as copper sulfate, tricopper hydroxide, hemihydrate, copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with an amino acid; or both; copper glycinate; copper alanate; or any and all combinations thereof, as component (3).

[0714] In some embodiments, the combination of the present invention comprises between about 40 g / ha and about 90 g / ha, typically between about 43.75 g / ha and 87.5 g / ha of a polyphenol-based component (1); and as component (2) a strobilurin fungicide selected from 60 g / ha-70 g / ha, preferably about 65 g / ha of picoxystrobin; and at least one selected from about 75 g / ha-110 g / ha, preferably about 80 g / ha of tebuconazole; and 60 g / ha-80 g / ha, for example about 63 g / ha of prothioconazole. Azole fungicides; and azole fungicide mixture combinations thereof, which are combined with a copper-based compound selected from copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, copper oxychlorosulfate (COCS), tricopper sulfate such as copper sulfate, tricopper hydroxide, hemihydrate, copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with amino acids; copper glycinate; copper alanate; or any and all combinations thereof, as component (3).

[0715] In some embodiments, the combination of the present invention comprises between about 10 g / ha and 350 g / ha, typically 40 g / ha-90 g / ha, of a polyphenol-based component (1); and an azole fungicide in combination with an SDHI fungicide selected from the group consisting of: penthiopyrad; boscalid; flutolanil; fluopyram; fluopyram; fluoxapyram; flutopyram; fluoxazolidinone; bixafen; fluopyram; indopyram; benzovintriazole (fluopyram) and any SDHI fungicide thereof Combination as component (2), which is combined with a copper-based compound selected from the group consisting of copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, copper oxychlorosulfate (COCS), tricopper sulfate such as copper sulfate, tricopper hydroxide, hemihydrate, copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with an amino acid; copper glycinate; copper alanate; or any and all combinations thereof, as component (3).

[0716] In a preferred embodiment comprising a polyphenol-based component (1), a systemic fungicide compound (A) as component (2), component (3) does not comprise any protectant fungicide, but only comprises copper-based compounds selected from the group consisting of copper acetate, copper chloride, copper chlorate, copper formate, copper hexafluorosilicate, copper nitrate, copper chromate, copper sulfate pentahydrate, Bordeaux mixture, copper hydroxide, copper oxychlorosulfate (COCS), tricopper sulfate such as copper sulfate, tricopper hydroxide, hemihydrate, copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with amino acids; copper glycinate; copper alanate; or any and all combinations thereof.

[0717] In several embodiments, the combination of the present invention comprises about 40 g / ha-90 g / ha, typically about 43.75 g / ha-87.5 g / ha, of a combined extract of natural water-soluble tannins and proanthocyanidins as the polyphenol-based component (1), and a combination of 80 g / ha of tebuconazole and 65 g / ha of picoxystrobin as the component (2).

[0718] In several embodiments, the combination of the present invention comprises as a polyphenol-based component (1) about 40 g / ha-90 g / ha, typically about 43.75 g / ha-87.5 g / ha, a combined extract of natural water-soluble tannins and proanthocyanidins, 80 g / ha of a combination of tebuconazole and 65 g / ha of picoxystrobin as a component (2), and 8.75 g / ha of metallic copper in the form of copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with amino acids; copper glycinate; copper alanate; or any and all copper-based combinations thereof as a component (3).

[0719] In several embodiments, the combination of the present invention comprises about 40 g / ha of a combined extract of natural water-soluble tannins and proanthocyanidins as a polyphenol-based component (1), a combination of 80 g / ha of tebuconazole and 65 g / ha of picoxystrobin as a component (2), and 8.75 g / ha of metallic copper in the form of copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with amino acids; copper glycinate; copper alanate; or any and all copper-based combinations thereof, as a component (3).

[0720] In an embodiment, the combination of the invention comprises about 40 g / ha-90 g / ha, typically about 43.75 g / ha-87.5 g / ha of a combined extract of natural water-soluble tannins and proanthocyanidins as a polyphenol-based component (1), 80 g / ha of a combination of tebuconazole and 65 g / ha of picoxystrobin as a component (2) and 600 g / ha of a protectant fungicide such as EBDC mancozeb as a component (3).

[0721] In an embodiment, the combination of the invention comprises as a polyphenol-based component (1) about 40 g / ha-90 g / ha, typically about 43.75 g / ha-87.5 g / ha, a combined extract of natural water-soluble tannins and proanthocyanidins, 80 g / ha of a combination of tebuconazole and 65 g / ha of picoxystrobin as component (2) and 600 g / ha of a protectant fungicide such as EBDC, mancozeb and a mixture of: 8.75 g / ha of metallic copper in the form of copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with amino acids; copper glycinate; copper alanate; or any and all copper-based combinations thereof, as component (3).

[0722] In an embodiment, the combination of the invention comprises about 40 g / ha of a combined extract of natural water-soluble tannins and proanthocyanidins as a polyphenol-based component (1), a combination of 80 g / ha tebuconazole and 65 g / ha picoxystrobin as component (2), and 600 g / ha of a protectant fungicide such as EBDC mancozeb and a mixture of: 8.75 g / ha of metallic copper in the form of copper chelated (or complexed) with, for example, EDTA; copper chelated (or complexed) with amino acids; copper glycinate; copper alanate; or any and all copper-based combinations thereof.

[0723] In some embodiments, the combination of the present invention comprises a combination of components (1) and (3) for use in combination with the systemic fungicide of component (2), these systemic fungicides are selected from any one of the following mixtures or other mixtures maintaining the ratio of each of the following items

[0724] Polyphenols = 88 + copper 7.5g / ha, about 12:1

[0725] Polyphenols = 88 + copper 7.5g / ha + mancozeb 600g / ha, about 12:1:80

[0726] Polyphenols = 44 + copper 7.5g / ha, about 6:1

[0727] Polyphenols = 44 + copper 7.5g / ha, + mancozeb 600g / ha, about 6:1:80

[0728] Polyphenols = 87.5 + copper 175g / ha, about 1:2

[0729] Polyphenols = 87.5 + copper 175g / ha, + mancozeb 600g / ha, about 1:2:3.4 [about 1:2:3]

[0730] Polyphenols = 44 + copper 8.75g / ha, about 5:1

[0731] Polyphenols = 44 + copper 8.75g / ha + mancozeb 600g / ha, about 5:1:69

[0732] Polyphenols = 87.5 + copper 8.75 g / ha, about 10:1

[0733] Polyphenols = 87.5 + copper 8.75g / ha + mancozeb 600g / ha, about 10:1:69

[0734] Polyphenols = 44 + copper 3.75g / ha, about 12:1

[0735] Polyphenols = 22 + copper 3.75g / ha + mancozeb 300g / ha, about 6:1:80

[0736] Polyphenols = 7.5g / ha + copper 10g / ha, about 3:4

[0737] Polyphenols = 7.5g / ha + copper 10g / ha, + mancozeb 300g / ha, about 3:4:120 polyphenols = 15g / ha + copper 20g / ha, about 3:4.

[0738] Polyphenols = 15g / ha + copper 20g / ha + mancozeb 300g / ha, about 3:4:120.

[0739] Polyphenols 35% + Chelated Copper 30%

[0740] Polyphenols 35% + Chelated Copper 3%

[0741] In some particularly noteworthy embodiments, the systemic fungicide of component (2) for use in combination with the above-mentioned combination of components (1) and (3) is selected from a combination of at least two of the following: picoxystrobin; azoxystrobin; fluopicolide; tebuconazole and prothioconazole.

[0742] Dosage Form Example #12

[0743] In a particular embodiment, the combination of the invention is prepared by combining a composition of a polyphenol-based compound and a copper-based compound [components (1) and (3)] with a separate mixture / composition of two systemic fungicides and optionally mancozeb (EBDC) [component (2) or component (2) + protectant component (3)]. The preparative combination can be made at the time of use, either from a kit or from separate commercially available compositions, etc. (including both compositions), or from a tank mix adapted according to the instructions or otherwise to a composition combined within the scope of the invention.

[0744] In some embodiments, the combination is a mixture. In some embodiments, the combination is a kit of parts intended or adapted to be mixed prior to administration. In some embodiments, the parts of the kit are separate compositions of diluted combination and / or mixing.

[0745] In some embodiments, the weight ratio of the polyphenol-based component (1) to the component (2) comprising the fungicide (A) in any combination disclosed or suggested herein is from about 1:100 to about 100:1. In some embodiments, the weight ratio of the polyphenol-based component (1) to the component (2) comprising the fungicide (A) in any combination disclosed or suggested herein is from about 1:25 to about 25:1. In some embodiments, the weight ratio of the polyphenol-based component (1) to the component (2) comprising the fungicide (A) in any combination disclosed or suggested herein is from about 1:10 to about 10:1. In some embodiments, the weight ratio of the polyphenol-based component (1) to the component (2) comprising the fungicide (A) in any combination disclosed or suggested herein is from about 1:5 to 5:1. In some embodiments, the weight ratio of the polyphenol-based component (1) to the component (2) comprising the fungicide (A) in any combination disclosed or suggested herein is about 1:2 to 2:1. In some embodiments, the weight ratio of the polyphenol-based component (1) to the component (2) comprising the fungicide (A) in any combination disclosed or suggested herein is about 1:1.

[0746] In some embodiments, component (2) fungicide (A) is a combination of two or more fungicides from the same fungicidal classification group or from different fungicidal classification groups, the fungicides being classified by chemical structure or their mode of action.

[0747] In some embodiments, the difference in the fungicide group refers to, but is not limited to, the difference in the chemical structure and / or mode of action of the fungicide, for example, QiI fungicides (quinone endogenous inhibitors), SDHI fungicides (succinate dehydrogenase inhibitors), azole fungicides, morpholine fungicides, strobilurin fungicides.

[0748] Improved Combination Example #13

[0749] In some embodiments, the combination comprises an improved combination wherein it is synergistic, particularly in its fungicidal efficacy or other beneficial attributes associated with any one or more of the active compounds contained in the combination, compared to when each is used independently.

[0750] In some embodiments, the combination comprises an improved combination in which they are synergistic, particularly in their fungicidal efficacy or other beneficial attributes associated with the combination of active compounds of component (2) and component (3) (when present) contained in the combination together with component (1), compared to when only component (2) and component (3) (when present) are used without component (1).

[0751] In some copper-containing embodiments, the combinations of the invention include improved combinations in that they have improved plant health benefits, such as reduced stress (e.g., improved abiotic stress mitigation) and phytotoxicity from copper relative to comparable copper-containing fungicidal combinations that do not contain a polyphenol-based component, which require much higher copper levels.

[0752] In some embodiments, the combination comprises an improved combination, wherein an amount of a polyphenol-based component (1) and an amount of a component (2) comprising at least one fungicide (A) in a combined application as described above are more effective in treating a plant or locus against fungal and / or bacterial infection than when an amount of a polyphenol-based component (1) and an amount of a component (2) fungicide (A) are applied alone without applying other components.

[0753] In some embodiments, the combinations of the present invention include improved combinations wherein a certain amount of a polyphenol-based component (1) and a certain amount of a component (2) comprising at least one fungicide (A) are more effective in treating a plant or locus against fungal and / or bacterial / microbial infection if applied in combination than if the same amount of component (2) is not applied in combination with the same amount of a polyphenol-based component.

[0754] In some embodiments, the combination comprises an improved combination wherein a certain amount of polyphenol-based component (1) is more effective in treating a plant or locus against fungal infection if applied in combination with a certain amount of component (2) comprising a fungicide (A) than if the same amount of the polyphenol-based component is not applied in combination with the same amount of the fungicide (A).

[0755] In some embodiments, the combination comprises an improved combination wherein a certain amount of the polyphenol-based component (1) improves the fungicidal efficacy of a certain amount of the component (2) fungicide compared to when the same amount of the fungicide is not applied in combination with the certain amount of the polyphenol-based component.

[0756] In some embodiments, the locus is soil.

[0757] In some embodiments, the combination comprises an improved combination, wherein the amount of polyphenol-based component (1) improves the beneficial effects of applying the amount of fungicide component (2) compared to when the same amount of fungicide is not applied in combination with an amount of polyphenol-based component. The beneficial effects are any of: improved emergence, crop yield, protein content, oil content, starch content, more developed root system (improved root growth), improved stress resistance or improved abiotic stress relief (e.g., for drought, heat, salt, UV, water, cold), reduced ethylene (reduced production and / or inhibition of uptake), reduced phytotoxicity, increased plant height, larger leaves, fewer dead basal leaves, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less input required (e.g., fertilizer or water), fewer seeds required, more effective tillers, earlier flowering, earlier grain maturity, fewer plant segments (lodging), shorter stalks, increased stalk diameter, increased shoot growth, increased plant vigor, increased plant density, and earlier and better germination.

[0758] In some embodiments, the combination of the present invention comprises an improved three-component combination in which the amount of copper-based compound and / or protectant fungicide of component (3) is significantly reduced without any loss of efficacy when applied in combination with a certain amount of polyphenol-based component (1) and a certain amount of component (2) comprising at least one fungicide (A) to treat plants or loci against fungal and / or bacterial infections as previously described, compared to a combination comprising the same amount of component (2) fungicide (A) applied and the same component (3) copper-based compound and / or protectant fungicide without a certain amount of polyphenol-based component (1).

[0759] In some embodiments, in the three-component fungicidal combination of the present invention, the reduction in the amount of copper-based compounds and / or protectant fungicides of component (3) as described above (without loss of efficacy) is exemplified by any or all of the following items: the fluazinam content is between about 200 g / ha-500 g / ha and preferably about 300 g / ha; the thiophanate-methyl content is between about 400 g / ha-1200 g / ha and preferably about 700 g / ha; the mancozeb content is between about 400 g / ha-1500 g / ha and preferably about 700 g / ha, the copper-based compound (based on metallic copper content) is between about 1 g / ha-350 g / ha, preferably between about 5 g / ha-50 g / ha, and even more preferably less than 20 g / ha and desirably less than 10 g / ha. The present invention enables the reduction of the amount of copper-based compounds and / or protectant fungicides (e.g., ethylenebisdithiocarbamate fungicides, such as mancozeb) required for the fungicidal efficacy of systemic fungicides, or even eliminates the need to use them, which generally results in equal or superior fungicidal activity while reducing the incidence of phytotoxicity.

[0760] In some embodiments, the multi-component composition of the present invention comprises a polyphenol-based compound as component (1) and a mixture of a triazole fungicide and a strobilurin fungicide as component (2) and an ethylenebisdithiocarbamate (EBDC) fungicide as component (3), wherein the amount of EBDC is reduced by at least 25% compared to previously known fungicidal combinations of the same mixture of a triazole fungicide and a strobilurin fungicide and EBDC.

[0761] In some embodiments, the multi-component compositions of the present invention comprise a polyphenol-based compound as component (1) and a mixture of a triazole fungicide and a strobilurin fungicide as component (2) and chelated or complexed copper as component (3). In these combinations, the copper compound can significantly reduce the amount of ethylenebisdithiocarbamate (EBDC) protectant fungicide encountered in previously known fungicidal combinations containing the same mixture of triazole fungicides and strobilurin fungicides and EBDC (such as mancozeb), or completely replace the EBDC protectant fungicide.

[0762] In some multi-component combination embodiments, the fungicidal efficacy of the compound comprising component (2) is increased by at least 10%, about 20% or more, or about 30% and above compared to the same amount of systemic fungicide component (2) compound (A) applied alone. In some embodiments, the fungicidal efficacy is increased by at least 50%, about 100% or more, about 200% or more, or about 300% or more compared to the same amount of fungicide applied alone.

[0763] In some embodiments, the fungicidal efficacy is measured in a treated area of ​​the plant. In some embodiments, the fungicidal efficacy is measured in an untreated area of ​​the plant. In some embodiments, the fungicidal efficacy is increased in a treated area of ​​the soil or locus. In some embodiments, the fungicidal efficacy is increased in an untreated area of ​​the soil or locus.

[0764] In some embodiments, fungicidal efficacy is measured at least 7 days after the initial and / or each treatment or application.

[0765] In some embodiments, the fungicidal efficacy is measured at least 14 days after the initial and / or each treatment or application. In some embodiments, the fungicidal efficacy is measured at least 21 days after the initial and / or each treatment or application. In some embodiments, the fungicidal efficacy is measured at least 28 days after the initial and / or each treatment or application.

[0766] In some embodiments, the combinations include improved combinations, wherein substantially similar levels of fungicidal efficacy are achieved by using lower amounts of the polyphenol-based component and / or the (typically systemic) fungicide (A).

[0767] Although the polyphenol-based compounds comprising component (1) may themselves have a certain degree of inherent fungicidal efficacy, in some embodiments, an amount of the polyphenol-based component in the combination comprises less than a fungicidally effective amount of the polyphenol-based component when the polyphenol-based component is used alone. In some embodiments, the amount of the polyphenol-based component is less than its fungicidally effective amount.

[0768] In some embodiments, the amount of the fungicide compound (A) of component (2) is less than the fungicidally effective amount of the fungicide when the fungicide is used alone.

[0769] In some embodiments, the combination comprises an improved combination wherein the amount of the polyphenol-based component is effective to increase the sensitivity of the fungus to the amount of the (typically systemic) fungicide component (2) as compared to the sensitivity of the fungus to the amount of the fungicide when the amount of the fungicide is not applied in conjunction with the amount of the polyphenol-based component.

[0770] In some embodiments, the combination comprises an improved combination wherein the amount of the polyphenol-based component is effective to increase the bioavailability of the amount of component (2) (systemic) fungicide as compared to the bioavailability of the amount of the additional fungicide when the amount of the additional fungicide is not applied in conjunction with the amount of the polyphenol-based component.

[0771] In some embodiments, the combination comprises an improved combination wherein the amount of the polyphenol-based component is within a range effective to increase the bioavailability of the amount of component (2) (systemic) fungicide as compared to the bioavailability of the amount of the additional fungicide when the amount of the additional fungicide is not applied in conjunction with the amount of the polyphenol-based component.

[0772] In some embodiments, the combination comprises an improved combination wherein the inclusion of a copper-based compound as component (3) can reduce the amount of polyphenol-based component required to effectively increase the bioavailability of a certain amount of component (2) (systemic) fungicide due to the effect of the copper-based compound on the polyphenol-based component as compared to the bioavailability of a certain amount of component (2) fungicide when the certain amount of component (2) fungicide is not applied in conjunction with a certain amount of polyphenol-based component.

[0773] In some embodiments, the combination comprises an improved combination wherein the inclusion of a minimal amount of a copper-based compound (e.g., significantly less than 50 g / ha) as component (3) can reduce the amount of a polyphenol-based component required to effectively increase the bioavailability of a certain amount of component (2) (systemic) fungicide by about half or less due to the effect of the copper-based compound on the polyphenol-based component, as compared to the bioavailability of a certain amount of component (2) fungicide when the amount of the component (2) fungicide is not applied in conjunction with the amount of the polyphenol-based component.

[0774] Increasing bioavailability includes increasing the penetration of the amount of component (2) (systemic) fungicide (A) into the plant. The component (2) fungicide compound can penetrate the plant by penetrating the leaves (including penetrating the leaf cuticle) and / or the roots. In some embodiments, the combination of the amount of component (2) fungicide (A) and the amount of polyphenol-based component increases the penetration of the amount of component (2) (systemic) fungicide into the plant. In some embodiments, the combination of the amount of component (2) (systemic) fungicide and the amount of polyphenol-based component increases the penetration of the amount of systemic fungicide into the leaves of the plant. In some embodiments, the combination of the amount of additional fungicide and the amount of polyphenol-based component increases the penetration of the additional fungicide into the roots of the plant.

[0775] Increasing bioavailability also includes increasing the transfer of the amount of systemic fungicide once inside the plant (including leaves). In some embodiments, the combination of the amount of additional fungicide and the amount of polyphenol-based component increases the transfer of the amount of additional fungicide after penetration into the plant.

[0776] While not wishing to be bound by theory, it is possible that the above suggested increase in the bioavailability of the systemic fungicide (A), which is typically achieved by combination with a polyphenol-based compound, allows the application of a combination comprising a reduced amount of systemic fungicide without any loss of fungicidal efficacy and the possibility of reduced phytotoxicity levels.

[0777] In some embodiments, the combination comprises an improved combination, wherein the combination is more effective in treating a plant or locus against fungal and / or bacterial / microbial infection than when the same amount of each fungicide comprising component (2) is applied alone.

[0778] In some embodiments where the fungicide component (2) of the multi-component combination of the present invention comprises two or more individual compounds selected from systemic fungicides (A), the combination of fungicides (A) is even more effective in treating plants or loci against fungal infections than the same fungicidal compounds applied in combination in the same amounts without the polyphenol-based component (1). Thus, for example, where a mixture of two systemic fungicides has a known but merely additive level of fungicidal efficacy when applied in combination, the inclusion of the polyphenol-based component (1) can convert the efficacy of the mixture of the same fungicidal compounds to a level that is considered fungicidally synergistic.

[0779] Without wishing to be bound by any theory, the increased effectiveness or efficacy of the combinations of the present invention compared to combinations in the absence of the polyphenol-based component may be due to increased bioavailability and / or uptake of the systemic fungicide by the fungal pathogen.

[0780] In some embodiments, the combination comprises an improved combination wherein the amount of the fungicide compound of component (2) and the amount of the polyphenol-based component (1) in combination are more effective in treating the plant or locus against fungal and / or bacterial / microbial infection than when the amount of the polyphenol-based component and the amount of the systemic fungicide are applied separately. In some embodiments, the combination of at least one of the polyphenol-based component (1) and the component (2) fungicide (A) is more effective in treating the plant or soil against fungal infection than when the fungicide compound components are applied separately in the same amounts or ratios.

[0781] Treatment, Efficacy and Benefits Example #14

[0782] In some embodiments, the combination of the present invention comprises one or more of a combination, mixture and / or composition of a polyphenol-based component (1) and at least one fungicide (A) compound that is more effective in treating plants or soil against fungal infections than when the same amount of each fungicide (A) compound is applied alone and not in combination with the polyphenol-based compound.

[0783] In some embodiments, treating a plant or locus to combat fungal infection comprises inhibiting fungal mycelium formation.

[0784] In some embodiments, treating a plant or locus to resist fungal and / or bacterial infection comprises combating a phytopathogenic disease on the plant or locus.

[0785] In some embodiments, treating a plant or locus to resist fungal and / or bacterial infection comprises protecting the plant or locus from fungal and / or bacterial infestation.

[0786] In some embodiments, treating a plant or locus to combat fungal infection comprises preventing fungal and / or bacterial infection of the plant or locus.

[0787] In some embodiments, treating a plant or locus to combat fungal and / or bacterial infection comprises controlling fungal and / or bacterial diseases affecting the plant or locus.

[0788] In some embodiments, treating a plant or locus to combat fungal and / or bacterial infection comprises controlling a fungal and / or bacterial pathogen, group of fungal and / or bacterial pathogens, or class of fungal and / or bacterial pathogens affecting the plant or locus.

[0789] In some embodiments, treating a plant or locus to combat fungal and / or bacterial infection comprises controlling fungal diseases caused by a fungal and / or bacterial pathogen, group or class of fungal and / or bacterial pathogens affecting the plant or locus.

[0790] In some embodiments, treating a plant or locus to resist fungal and / or bacterial infection includes reducing fungal and / or bacterial infection of the plant or locus.

[0791] In some embodiments, the combination comprises an improved combination wherein the combination provides extended protection against and / or control of fungal and / or bacterial infection compared to when an amount of a polyphenol-based component and an amount of a systemic fungicide are applied alone.

[0792] In some embodiments, the protection period against fungal infection and / or the control period of fungal and / or bacterial infection is extended by at least 7 days, 14 days, 21 days, or 28 days.

[0793] In some embodiments, the combination comprises an improved combination, wherein the combination reduces the amount of time required to achieve a level of fungal and / or bacterial control compared to when an amount of a polyphenol-based component and an amount of a systemic fungicide are applied alone.

[0794] An example of a reduction is that if each systemic fungicide applied alone achieves 50% control of fungal diseases 7 days after application, then when each combination, mixture and / or composition is applied at that amount, the combination disclosed herein achieves 50% control of fungal and / or bacterial diseases 2 days after application.

[0795] In some embodiments, the amount of time required to achieve a certain level of fungal and / or bacterial control is reduced by at least 1 day, 2 days, 3 days, 4 days, 5 days, 7 days, 10 days, 14 days, or 21 days, or 28 days.

[0796] In some embodiments, the combination includes an improved combination, wherein the combination improves plant development compared to plant development affected by the same type and degree of fungal and / or bacterial infection to which the combination is not applied. In some embodiments, the plant is a crop plant. In some embodiments, the additional fungicide as part of the combination is more effective in improving plant development than when applied alone in the same amount. In some embodiments, the polyphenol-based component as part of the combination is more effective in improving plant development than when applied alone in the same amount.

[0797] In some embodiments, plant development is improved by treating the plant to resist fungal and / or bacterial attack.

[0798] In some embodiments, improving plant development comprises enhancing crop plants. In some embodiments, improving plant development comprises improving plant quality.

[0799] Improving plant development includes, but is not limited to, strengthening the root system, strengthening the plant's shoots, enhancing plant vigor, enhancing the greening effect on leaves, and / or increasing the potential yield of the plant.

[0800] In some embodiments, improving plant development comprises enhancing the root system. In some embodiments, the enhancement of the root system is measured by root weight. In some embodiments, root weight is increased by at least 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.

[0801] In some embodiments, the combination is more effective in controlling a pathogen than each AI or combination of AIs in the combination used alone.

[0802] In some embodiments, the amounts are optimized to provide a synergistic effect.

[0803] In some embodiments, the combination exhibits a synergistic effect between the polyphenol-based component and the at least one fungicide.

[0804] In some embodiments, an amount of a polyphenol-based component and an amount of at least one systemic fungicide, if applied in combination, are more effective in treating plants or soil against fungal and / or bacterial infection than the same amount of each fungicide applied alone.

[0805] In some embodiments, an amount of the polyphenol-based component and an amount of at least one additional fungicide, if applied together, are more effective in treating plants or soil against fungal infection than the same amount of each fungicide applied alone.

[0806] In some embodiments, an amount of the polyphenol-based component, an amount of at least one systemic fungicide in a combination, mixture, and / or composition, when applied in combination, is more effective in treating plants or soil against fungal infection than the same amount of each fungicide applied alone.

[0807] In the noted embodiments, the combinations according to the invention may also contain more than one of the following active components (a), (b), (c), (d), (e), to increase and / or broaden the disease control spectrum when desired.

[0808] (a) QiI fungicides, (b) strobilurin fungicides, (c) succinate dehydrogenase inhibitor (SDHI) fungicides, (d) triazole fungicides, and (e) morpholine fungicides.

[0809] Methods and uses

[0810] Treatment Methods, Applications, Rates and Levels Example #15

[0811] Embodiments of the present invention include providing methods of treating plants or loci to resist fungal and / or bacterial infection, which methods include applying to the plants or loci a combination of: (1) an amount of a polyphenol-based component as previously described, and (2) at least one systemic fungicide (A) selected from the group consisting of QiI fungicides, strobilurin fungicides, SDHI fungicides, azole fungicides, and morpholine fungicides, thereby treating the plants or loci to resist fungal and / or bacterial infection, wherein (i) the method is more effective against fungal and / or bacterial infection than when an amount of the polyphenol-based component and an amount of the fungicide are applied alone, and / or (ii) the amount of the polyphenol-based component improves the fungicidal efficacy of the amount of the fungicide compared to when the same amount of additional fungicide is not applied in combination with the amount of the polyphenol-based component.

[0812] An embodiment of the present invention provides a combination for controlling diseases caused by pathogens in plants, the combination comprising (1) a certain amount of a polyphenol-based component and as component (2) a certain amount of at least one fungicide selected from the group consisting of QiI fungicides, strobilurin fungicides, SDHI fungicides, azole fungicides and morpholine fungicides.

[0813] An embodiment of the present invention provides a method for controlling diseases caused by pathogens in plants, the method comprising applying a combination of (1) a certain amount of a polyphenol-based component and as component (2) a certain amount of at least one fungicide selected from the group consisting of QiI fungicides, strobilurin fungicides, SDHI fungicides, azole fungicides and morpholine fungicides to plants, propagation materials of plants and / or loci of plants.

[0814] In some embodiments, the method comprises applying the polyphenol-based component and the fungicide (A) at any of the ratios described herein.

[0815] The rate of application of combinations, mixtures, or compositions according to embodiments of the present invention will depend on the specific type of fungi and / or bacteria to be controlled, the degree of control desired, and the time and method of application.

[0816] In some embodiments, the combination, mixture, or composition is applied at a rate of about 25 grams total active ingredient per hectare (g ai / ha) to about 2000 g ai / ha, based on the total amount of active ingredients in the combination, mixture, or composition.

[0817] In some embodiments, the polyphenol-based component is applied at a rate of about 10 g ai / ha to about 350 g ai / ha, preferably 40 g ai / ha to about 90 g ai / ha. In some embodiments, the polyphenol-based component is applied at a rate of about 90 g ai / ha.

[0818] In some embodiments, fenpropidin is applied at a rate of about 100 g ai / ha to about 300 g ai / ha, preferably 120 g ai / ha to about 250 g ai / ha. In some embodiments, fenpropidin is applied at a rate of about 150 g ai / ha.

[0819] In some embodiments, benzovinflumizone is applied at a rate of about 20 g ai / ha to about 80 g ai / ha, preferably 30 g ai. / ha to about 50 g ai / ha. In some embodiments, benzovinflumizone is applied at a rate of about 40 g ai / ha.

[0820] In some embodiments, fluopyrab is applied at a rate of about 40 g ai / ha to about 100 g ai / ha. In some embodiments, fluopyrab is applied at a rate of about 50 g ai / ha.

[0821] In some embodiments, bixafen is applied at a rate of about 40 g ai / ha to about 100 g ai / ha, preferably 50 g ai. / ha to about 80 g ai / ha. In some embodiments, bixafen is applied at a rate of about 60 g ai / ha.

[0822] In some embodiments, fenoxystrobin is applied at a rate of about 40 g ai / ha to about 200 g ai / ha, preferably 45 g ai / ha to about 100 g ai / ha, and more preferably 50 g ai / ha to about 80 g ai / ha. In some embodiments, fenoxystrobin is applied at a rate of about 80 g ai / ha.

[0823] In some embodiments, mancozeb is applied at a rate of about 400 g ai / ha to about 1500 g ai / ha. In some embodiments, mancozeb is applied at a rate of about 700 g ai / ha.

[0824] In some embodiments, thiophanate-methyl is applied at a rate of about 400 g ai / ha to about 1200 g ai / ha. In some embodiments, thiophanate-methyl is applied at a rate of about 700 g ai / ha.

[0825] In some embodiments, fluazinam is applied at a rate of about 200 g ai / ha to about 500 g ai / ha. In some embodiments, fluazinam is applied at a rate of about 300 g ai / ha.

[0826] In some embodiments, the copper-based compound is applied at a rate of about 30 g ai / ha to about 350 g ai / ha as metallic copper. In some embodiments, the copper-based compound is applied at a rate of about 175 g ai / ha

[0827] In some embodiments, tebuconazole is applied at a rate of about 40 g ai / ha to about 150 g ai / ha, preferably 75 g ai / ha to about 110 g ai / ha. In some embodiments, tebuconazole is applied at a rate of about 80 g ai / ha.

[0828] In some embodiments, prothioconazole is applied at a rate of about 40 g ai / ha to about 120 g ai / ha, preferably 60 g ai / ha to about 80 g ai / ha. In some embodiments, prothioconazole is applied at a rate of about 70 g ai / ha. In some embodiments, cyproconazole is applied at a rate of about 15 g ai. / ha to about 80 g ai / ha, preferably 24 g ai / ha to about 42 g ai. / ha. In some embodiments, cyproconazole is applied at a rate of about 30 g ai / ha.

[0829] In some embodiments, flutriafol is applied at a rate of about 50 g ai / ha to about 150 g ai / ha. In some embodiments, flutriafol is applied at a rate of about 100 g ai / ha.

[0830] In some embodiments, difenoconazole is applied at a rate of about 50 g ai / ha to about 120 g ai / ha, preferably 40 g ai. / ha to about 100 g ai / ha, more preferably 50 g ai / ha to about 80 g ai / ha. In some embodiments, difenoconazole is applied at a rate of about 70 g ai / ha.

[0831] In some embodiments, mefenamic acid is applied at a rate of about 50 g ai / ha to about 150 g ai / ha, preferably 75 g ai. / ha to about 100 g ai / ha. In some embodiments, mefenamic acid is applied at a rate of about 100 g ai / ha.

[0832] In some embodiments, picoxystrobin is applied at a rate of about 40 g ai / ha to about 200 g ai / ha, preferably 50 g ai / ha to about 150 g ai / ha. In some embodiments, picoxystrobin is applied at a rate of about 60 g ai / ha.

[0833] In some embodiments, azoxystrobin is applied at a rate of about 40 g ai / ha to about 200 g ai / ha, preferably 50 g ai / ha to about 80 g ai / ha. In some embodiments, azoxystrobin is applied at a rate of about 60 g ai / ha.

[0834] In some embodiments, tosoxime-butyl is applied at a rate of about 50 g ai / ha to about 300 g ai / ha. In some embodiments, tosoxime-butyl is applied at a rate of about 120 g ai / ha.

[0835] In some embodiments, the combination, mixture, or composition of the present disclosure is applied at a rate of about 60 g ai. / ha to about 600 g ai. / ha. In some embodiments, the combination, mixture, or composition is applied at a rate of about 100 g ai. / ha to about 200 g ai. / ha. In some embodiments, the combination, mixture, or composition is applied at a rate of about 100 g ai. / ha to about 130 g ai. / ha.

[0836] The components of the combinations, mixtures or compositions of the present disclosure can be applied separately or as part of a multi-part fungicidal system. The components of the combinations, mixtures or compositions of the present disclosure can be applied separately or as part of a multi-part fungicidal system. Therefore, the methods and uses disclosed herein include preparing combinations, mixtures and compositions from the component parts prior to application or use.

[0837] In some embodiments, the components of the combinations, mixtures, or compositions of the disclosure are administered simultaneously.

[0838] In some embodiments, the components of the combinations, mixtures, or compositions of the disclosure are administered contemporaneously.

[0839] In some embodiments, the components of the combinations, mixtures, or compositions of the disclosure are administered as sequential administrations.

[0840] In some embodiments, the components of the combinations, mixtures, or compositions of the present disclosure are applied at least once during the growing season.

[0841] In some embodiments, administration together according to the present invention refers to simultaneous, contemporaneous and / or consecutive administration.

[0842] In some embodiments, the components of the mixtures or compositions of the present disclosure are applied one or more times during the growing season.

[0843] In some embodiments, the components of the combinations, mixtures or compositions of the present disclosure are applied in soil applications. In some embodiments, the mixtures and / or compositions described herein are applied in foliar applications. In some embodiments, the components of the mixtures or compositions thereof are applied as seed treatments.

[0844] In some embodiments, the components of the combinations, mixtures, or compositions of the present disclosure are applied as a soil application, a foliar application, a seed treatment, and any combination thereof.

[0845] In some embodiments, the combinations, mixtures, or compositions of the disclosure are applied at least once during the growing season.

[0846] In some embodiments, the combinations, mixtures or compositions of the present disclosure are applied one or more times during the growing season. In some embodiments, the combinations, mixtures or compositions described herein are applied as soil applications. In some embodiments, the combinations, mixtures or compositions described herein are applied as foliar applications.

[0847] In some embodiments, controlling refers to, but is not limited to, therapeutic treatment, prophylactic treatment, permanent treatment, and any combination thereof.

[0848] In some embodiments, the method of control is therapeutic treatment.

[0849] In some embodiments, the method of control is a preventative treatment.

[0850] In some embodiments, the control method is a persistent process.

[0851] Application can be carried out before or after infection with harmful fungi and / or bacteria.

[0852] The application rate of the mixture disclosed herein will depend on the fungus to be controlled and / or the specific type of fungus, the desired degree of control, and the time and method of application. Typically, the mixture or composition described herein can be applied at an application rate between about 60 grams per hectare (g / ha) and about 2600 g / ha.

[0853] In some embodiments, the mixtures of the present invention are applied at a rate of between 0.1-10000 g ai / ha. In some embodiments, the mixtures of the present invention are applied at a rate of between 50-2000 g ai / ha. In some embodiments, the mixtures of the present invention are applied at a rate of between 100-750 g ai / ha.

[0854] In some embodiments, if applied as a seed treatment, the mixture of the present invention is applied at a rate between 2g / 100kg and 400g / 100kg of seed. In some embodiments, if applied as a seed treatment, the mixture of the present invention is applied at a rate between 2.5g / 100kg and 50g / 100kg of seed. In some embodiments, if applied as a seed treatment, the mixture of the present invention is applied at a rate between 2.5g / 100kg and 25g / 100kg of seed.

[0855] In some embodiments, if applied as a soil application, the mixture of the present invention is applied at a rate between 0.1 to 10,000 g / ha. In some embodiments, if applied as a soil application, the mixture of the present invention is applied at a rate between 1 to 5.000 g / ha.

[0856] In some embodiments, the mixture is a tank mix. Any combination described herein can be in the form of a tank mix. In some embodiments, each of the polyphenol-based component and the systemic fungicide is formulated in its own composition before tank mixing.

[0857] In general, the inventors have found that when a polyphenol-based component is added to a composition comprising a fungicide, the amount of systemic and protectant fungicidal active ingredients can be reduced by between 10% and 50%. Typically, the reduction in systemic and protectant fungicides can be between about 20% and 40% without loss of efficacy, and often with increased efficacy.

[0858] As shown later, several compositions comprising mancozeb, picoxystrobin, tebuconazole and a polyphenol-based component (polyphenols) were tested in field trials against Psora pachyrhizoma in soybean crops and compared with a composition comprising mancozeb, picoxystrobin, tebuconazole ( Products containing TOV but without polyphenols were compared. Several tested combinations also included copper compounds.

[0859] It was found that when the polyphenol-based component was added to a composition having the same dosage of mancozeb, picoxystrobin, tebuconazole, excellent fungicidal efficacy against Asian soybean rust was achieved, and that in treatments including the polyphenol-based component, equivalent fungicidal efficacy could be achieved with much lower dosages of mancozeb (e.g., 600 versus 880 g / ha).

[0860] Furthermore, equivalent fungicidal efficacy can be achieved when all fungicidal compounds in the composition are reduced by between 20% and 40%, as can be seen from the comparison of the composition applied at 1.8 L / Ha with the application of 2 L / Ha and 2.2 L / Ha.

[0861] See the table below which details some of the combinations used in the experiments.

[0862]

[0863] Furthermore, it was found that the addition of a polyphenol-based component to the fungicidal composition resulted in the additional benefit of less defoliation and significantly higher yield (in tonnes of grain per hectare), which in at least one trial was of the order of magnitude from about 4800 kg / ha to about 5000 kg / ha (based on yield estimates for each trial plot).

[0864] It was also found that when polyphenols were added to the combination of mancozeb, picoxystrobin and tebuconazole, more and greener leaves were found on the crop plants even at a lower application rate (1.8 L vs. 2.0 L), and this was more pronounced when applied at the same concentration at the same application rate.

[0865] Without being bound by theory, the greener and richer leaves may be related to the higher efficacy against Asian soybean rust as well as the anti-stress and biostimulatory effects of the polyphenol-based components.

[0866] Similarly, it was found that adding even small amounts of copper-based compounds significantly improved efficacy even when mancozeb was reduced by 25% or more.

[0867] None of the treatments resulted in phytotoxicity when assessed by visual inspection.

[0868] In the above mentioned treatments, the compositions were applied by spray mixtures containing 0.25 L / ha of the commercial adjuvant The commercial adjuvant contained 765 g / L of methyl soy oleate. Therefore, for each treatment, 191.25 g / L of methyl soy oleate was applied.

[0869] Composition

[0870] Composition, combination, mixture formulation and improvement example #16

[0871] In embodiments, the combination or mixture of the present invention may be formulated as one composition. The combination of the present invention may be formulated as separate compositions. The combination of the present invention may be formulated in more than one composition.

[0872] In embodiments, the combination of the invention may be formulated as separate compositions. The polyphenol-based composition of component (1) of the combination of the invention may be formulated and provided with preparation instructions or otherwise adapted for combination with a separate, typically commercially available composition of the systemic fungicide of component (2).

[0873] In embodiments, the combination of the invention may be formulated as separate compositions. The composition of the polyphenol-based component (1) of the combination of the invention may be formulated and provided with preparation instructions or otherwise adapted for combination with separate, typically commercially available compositions of the systemic fungicide of component (2) and the protectant fungicide of component (3).

[0874] In embodiments, the combination of the present invention may be formulated as separate compositions. The composition of the polyphenol-based component (1) of the combination of the present invention together with the copper-based compound of component (3) may be formulated and provided together with preparation instructions, or otherwise adapted for combination with a separate, typically commercially available composition of the systemic fungicide of component (2).

[0875] In embodiments, the combination of the present invention may be formulated as separate compositions. The composition of the polyphenol-based component (1) of the combination of the present invention together with the copper-based compound of component (3) may be formulated and provided with preparation instructions or otherwise adapted for combination with a separate, typically commercially available composition of the systemic fungicide of component (2) (mixed with the protectant fungicide of component (3)).

[0876] In embodiments, the combination of the invention may be formulated as separate compositions. The composition of the polyphenol-based component (1) of the combination of the invention together with the protectant fungicide of component (3) may be formulated and provided with preparation instructions or otherwise adapted for combination with a separate, typically commercially available composition of the systemic fungicide of component (2).

[0877] In an embodiment, the present invention also provides a fungicidal composition comprising any one of the combinations disclosed herein and an agriculturally acceptable carrier.

[0878] In embodiments, the present invention also provides fungicidal compositions for use in these combinations, comprising any one of the combinations disclosed herein and an agriculturally acceptable carrier.

[0879] In some embodiments, the combination comprises a composition.Any combination described herein can be in the form of a composition.

[0880] In embodiments, the combination, mixture or composition comprising a polyphenol-based component and at least one systemic fungicide (A) can be an improved combination, mixture or composition in any one way or any combination of ways as described below.

[0881] In some embodiments, the combination comprises an amount of a polyphenol-based component and an amount of at least one systemic fungicide (A).The combination comprising a polyphenol-based component and at least one fungicide (A) can be an improved combination in any one way or any combination of ways as described below.

[0882] In some embodiments, improving plant development comprises enhancing the shoots of the plant. In some embodiments, the enhancement of the shoots is measured by shoot weight. In some embodiments, the shoot weight increases by at least 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.

[0883] In some embodiments, improving plant development comprises enhancing plant vigor. In some embodiments, plant vigor is assessed using a relative vigor index. In some embodiments, plant vigor is increased by at least 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90%.

[0884] In some embodiments, improving plant development comprises enhancing the greening effect on leaves. In some embodiments, the greening effect on leaves is assessed using a relative vigor index. In some embodiments, the greening effect on leaves is increased by at least 1%, 5%, or 10%.

[0885] In some embodiments, improving plant development comprises increasing plant yield. In some embodiments, plant yield is increased by at least 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100% or more, or each and any intermediate value.

[0886] In some embodiments, the combination comprises an improved combination because it has resistance to drug resistance. Resistance to drug resistance refers to the effect of blocking the development or spread of drug resistance through the enhanced efficacy of the combination.

[0887] In some embodiments, the combination includes an improved combination wherein it has improved enhanced efficacy, improved persistent effect, improved anti-resistant activity, improved activity against resistant strains, improved green leaf area, improved greening effect, increased spectrum of disease activity, enhanced efficacy against diseases that cannot be controlled by fungicides alone, higher plant / crop yield, higher plant / crop protein content, higher plant / crop sugar content, higher plant / crop Brix level, better fruit color grading, higher thousand kernel weight, higher test weight or hectoliter weight, increased fruit size, increased number of marketable fruits, improved plant vigor, and / or reduced risk of adverse effects on plants.

[0888] Pathogens, Diseases and Crops

[0889] Pathogens, Diseases and Crops Example #17

[0890] The fungal pathogens to be treated by the combinations and methods disclosed herein can be one or more of the following: Alternaria species on vegetables, rapeseed, sugar beets and rice, such as Alternaria solani in tomatoes or Alternaria cucurbita in cucumbers or melons; Aphanomyces species on sugar beets and vegetables; Ascochyta species on cereals, beans and vegetables; Helminthosporium and Entohypha species on corn, cereals, rice and lawns, such as Monosporus zeae on corn; Blumeria graminis (powdery mildew) on cereals; Botrytis cinerea (grey mold) on strawberries, vegetables and flowers or Botrytis cinerea on onions; Lactuca oleracea on lettuce; Corn, soybeans, watercress, and rice. Cercospora species on rice, sugar beets, and coffee, such as brown spot on sugar beets or purple spot on soybeans; Cladosporium species on several crops; Ergot on rye; Corytophthora species on corn, cereals, and rice, such as Corytophthora graminicola on cereals and Corytophthora miyabe on rice; Colletotrichum species on vegetables, soybeans, and cotton, such as Colletotrichum flathead in peppers and soybeans; Entamoeba species and Pyricularia species on corn, cereals, rice, and lawns, such as Entamoeba hordei nettosporum on barley or yellow leaf spot on wheat; Grapevine Esca virus (Esca), which is caused by Phaeoacremonium chlamydosporum, P.Aleophilum and cyanobacterium punctatum (synonymous with phytomycete), Helminthosporium species on corn; Erysiphe graminearum and Erysiphe cucumeris on cucumbers; Fusarium and Verticillium species on various plants, such as Fusarium graminearum or Fusarium luteum on cereals or Fusarium oxysporum on various plants (such as tomatoes, for example); Graminoides on cereals; Gibberella species on cereals and rice (such as Gibberella fujikura on rice); Grain stain complex on rice; Helminthosporium species on corn and rice; Caulis coffeae on coffee; Microspores on cereals; Mycosphaera species on several crops, such as Mycosphaera brassicae on Brassicae; Psoralea graminearum on cereals; Cabbage, beans, and downy mildew species on bulbous plants, such as Brassica oleracea or downy mildew on cabbage; Phakopsora pachyrhizium and Phakopsora spp. on soybeans; Phoma species on soybeans, cucurbits, tomatoes, and brassicas; Phoma pseudosporum species on soybeans, sunflowers, and grapes; Phytophthora infestans on potatoes and tomatoes; Phytophthora species on various plants, such as Phytophthora capsici on bell peppers, Phytophthora citri citri and Phytophthora citri spp. on citrus; Downy mildew of grapevines on grapevines; Microsporales on various plants, such as Gastrosporium fusobacteria on alfalfa, tomatoes, and chickpeas; Pseudocorhinus tritici on cereals; Pseudocorhinus species on various plants, such as Pseudocorhinus cucumeris on cucumbers or Pseudocorhinus humulosa on hops; Magnaporthe oryzae, Pseudocorhinus oryzae, and Pseudocorhinus spp. on rice. Gram fungus, rice sheath rot, sheath rot, rice leaf smut; rice blast on turf and cereals; Pythium species on turf, rice, corn, cotton, rapeseed, sunflower, sugar beet, vegetables and other plants, for example, Pythium ultimum on various plants, Pythium aphanidermatum on turf; Cylindrospermum species on cereals, barley and cotton, for example, Cylindrospermum leaf spot on barley and Cylindrospermum leucoderma on cotton; Rhizoctonia species on cotton, rice, potatoes, turf, corn, rapeseed, sugar beet, vegetables and various plants, for example, Rhizoctonia solani on sugar beet and various plants; Rhizoctonia solani on barley, rye and triticale; Sclerotinia species on rapeseed, sunflower and lettuce; Septoria species on several crops Species such as Septoria oleracea in lettuce; Powdery mildew species such as Blumeria tritici on wheat; Powdery mildew species (synonymous with Uncinaria viticola) on grapevines; Trichoderma species on corn and turf; Corn head smut on corn; Thielavia species on soybeans and cotton; Tilletia species on cereals; Ustilago species on cereals, corn, and sugarcane such as Ustilago maydis on corn and Ustilago officinalis on soybeans; Septoria sojae (late season disease) on soybeans; Corynespora spp. (target spot) on soybeans; Diffused schizontria (powdery mildew) on soybeans; Anthracnosis on soybeans, Colletotrichum sclerotiorum (white mold) on soybeans. Puccinia sacchariflora (yellow rust) on sugarcane; Bromelain spp. (bromelain rot) on sugarcane. .

[0891] In some embodiments, the fungal pathogen group is Suberythraceae. In some embodiments, the fungal pathogen group is Phyllostomaceae. In some embodiments, the fungal pathogen group is Mycosphaeriaceae. In some embodiments, the fungal pathogen group is Angiospermaceae. In some embodiments, the fungal pathogen group is Powdery mildew family. In some embodiments, the fungal pathogen group is Trichodermaceae. In some embodiments, the fungal pathogen group is Sclerotiniaceae. In some embodiments, the fungal pathogen group is Dermeptinaceae. In some embodiments, the fungal pathogen group is Sclerotiniaceae. In some embodiments, the fungal pathogen group is Erythraceae. In some embodiments, the fungal pathogen group is Erythraceae. In some embodiments, the fungal pathogen group is Erythraceae. In some embodiments, the fungal pathogen group is Erythraceae. In some embodiments, the fungal pathogen group is Peronosporaceae. In some embodiments, the fungal pathogen group is Microsporaceae. In some embodiments, the fungal pathogen group is Lachnosporaceae. In some embodiments, the fungal pathogen group is Pseudocercoceae. In some embodiments, the fungal pathogen group is Venturaceae. In some embodiments, the fungal pathogen group is Suberythraceae. In some embodiments, the fungal pathogen group is Lachnosporaceae. In some embodiments, the fungal pathogen group is Corynosporaceae. In some embodiments, the fungal pathogen group is Pucciniaceae. In some embodiments, the fungal pathogen group is Chacosporaceae. In some embodiments, the fungal pathogen group is Lachnosporaceae. In some embodiments, the fungal pathogen group is Pucciniaceae. In some embodiments, the fungal pathogen group is Macroceratomycetes. In some embodiments, the fungal pathogen group is Exocystaceae. In some embodiments, the fungal pathogen group is Ustilaginaceae.

[0892] In some embodiments, the pathogen class is Cynomoriales. In some embodiments, the pathogen class is Botryales. In some embodiments, the pathogen class is Sootyales. In some embodiments, the pathogen class is Angiospermales. In some embodiments, the pathogen class is Erysipheales. In some embodiments, the pathogen class is Euroticales. In some embodiments, the pathogen class is Mollicutesales. In some embodiments, the pathogen class is Hypocreales. In some embodiments, the pathogen class is Peronosporales. In some embodiments, the pathogen class is Melanosporales. In some embodiments, the pathogen class is Lachnosporales. In some embodiments, the pathogen class is Pucciales. In some embodiments, the pathogen class is Pseudomonas. In some embodiments, the pathogen class is Pseudomonas. In some embodiments, the pathogen class is Pyrosporales. In some embodiments, the pathogen class is Exoascomycetes. In some embodiments, the pathogen class is Ustilagoras.

[0893] In some embodiments, the fungal pathogen is Botrytis cinerea. In some embodiments, the fungal pathogen is Microspore. In some embodiments, the fungal pathogen is Grape black rot. In some embodiments, the fungal pathogen is banana black streak leaf spot. In some embodiments, the fungal pathogen is wheat fermentation shell septorium. In some embodiments, the fungal pathogen is columnar septoria leaf spot. In some embodiments, the fungal pathogen is corn gray spot. In some embodiments, the fungal pathogen is white columnar septoria. In some embodiments, the fungal pathogen is beet cercospora. In some embodiments, the fungal pathogen is beet leaf spot. In some embodiments, the fungal pathogen is Rhizoctonia solani / rice sheath blight. In some embodiments, the fungal pathogen is wheat powdery mildew. In some embodiments, the fungal pathogen is powdery mildew of chrysanthemum. In some embodiments, the fungal pathogen is cucumber powdery mildew. In some embodiments, the fungal pathogen is grape powdery mildew. In some embodiments, the fungal pathogen is monocystis punctata. In some embodiments, the fungal pathogen is monocystis leucophylla. In some embodiments, the fungal pathogen is tataric powdery mildew. In some embodiments, the fungal pathogen is new tomato powdery mildew. In some embodiments, the fungal pathogen is powdery mildew of beet. In some embodiments, the fungal pathogen is powdery mildew of polygonia. In some embodiments, the fungal pathogen is an Aspergillus species. In some embodiments, the fungal pathogen is Botrytis cinerea. In some embodiments, the fungal pathogen is Sclerotinia sclerotiorum. In some embodiments, the fungal pathogen is Botrytis cinerea. In some embodiments, the fungal pathogen is Sclerotinia sclerotiorum. In some embodiments, the fungal pathogen is Sclerotinia sclerotiorum. In some embodiments, the fungal pathogen is Sclerotinia sclerotiorum. In some embodiments, the fungal pathogen is Pseudomonas spp ... In some embodiments, the fungal pathogen is Pyrenophora tritici. In some embodiments, the fungal pathogen is Pyrenophora truncatula. In some embodiments, the fungal pathogen is Pyrenophora teres. In some embodiments, the fungal pathogen is Pyrenophora indica.In some embodiments, the fungal pathogen is Heterosporium. In some embodiments, the fungal pathogen is Carbonaceous Corymborium. In some embodiments, the fungal pathogen is Alternaria species. In some embodiments, the fungal pathogen is Alternaria cucurbita. In some embodiments, the fungal pathogen is Cruciferae black stem pathogen. In some embodiments, the fungal pathogen is Alternaria alternata. In some embodiments, the fungal pathogen is Onion Corymborium. In some embodiments, the fungal pathogen is Alternaria apple. In some embodiments, the fungal pathogen is Alternaria species. In some embodiments, the fungal pathogen is Apple Venturia. In some embodiments, the fungal pathogen is Pear Venturia. In some embodiments, the fungal pathogen is Alternaria species. In some embodiments, the fungal pathogen is Chickpea Shell Dispora. In some embodiments, the fungal pathogen is Alternaria species. In some embodiments, the fungal pathogen is Corymboria spp. in mountain lentils. In some embodiments, the fungal pathogen is wheat concealed handle rust. In some embodiments, the fungal pathogen is wheat leaf rust. In some embodiments, the fungal pathogen is coffee camel rust. In some embodiments, the fungal pathogen is yam bean layer rust. In some embodiments, the fungal pathogen is beet rust. In some embodiments, the fungal pathogen is rice blast. In some embodiments, the fungal pathogen is a species of the genus Exocystis. In some embodiments, the fungal pathogen is Exocystis malformis. In some embodiments, the fungal pathogen is Ustilago maydis.

[0894] Methods of using the combinations of the present invention include use in controlling fungal groups, fungi and fungal pathogens, including those described herein.

[0895] Fungal infection may cause fungal diseases affecting plants or soil. In some embodiments, the present invention includes treating plants or soil to resist fungal infection, which includes treating plants or soil to resist fungal diseases with a combination of the present invention.

[0896] In some embodiments, the fungal disease is apple scab. In some embodiments, the fungal disease is seedling blight. In some embodiments, the fungal disease is ear disease. In some embodiments, the fungal disease is black rot. In some embodiments, the fungal disease is black banana leaf spot. In some embodiments, the fungal disease is Septoria. In some embodiments, the fungal disease is Cylindrospermum leaf spot. In some embodiments, the fungal disease is gray leaf spot. In some embodiments, the fungal disease is beet leaf spot. In some embodiments, the fungal disease is sheath blight. In some embodiments, the fungal disease is powdery mildew. In some embodiments, the fungal disease is Aspergillus ear rot. In some embodiments, the fungal disease is gray mold. In some embodiments, the fungal disease is sclerotinia. In some embodiments, the fungal disease is sclerotinia. In some embodiments, the fungal disease is Fusarium. In some embodiments, the fungal disease is Fusarium head blight. In some embodiments, the fungal disease is corn ear rot. In some embodiments, the fungal disease is crown root rot. In some embodiments, the fungal disease is black pod disease. In some embodiments, the fungal disease is downy mildew. In some embodiments, the fungal disease is late blight. In some embodiments, the fungal disease is coffee berry disease. In some embodiments, the fungal disease is anthracnose. In some embodiments, anthracnose. In some embodiments, the fungal disease is yellow spot. In some embodiments, the fungal disease is web spot. In some embodiments, the fungal disease is northern corn leaf blight. In some embodiments, the fungal disease is northern corn leaf spot. In some embodiments, the fungal disease is Phoma stem canker and leaf spot. In some embodiments, the fungal disease is Alternaria. In some embodiments, the fungal disease is pear brown spot. In some embodiments, the fungal disease is apple leaf spot. In some embodiments, the fungal disease is scab. In some embodiments, the fungal disease is early blight. In some embodiments, the fungal disease is pea leaf blight (Didymellapisi). In some embodiments, the fungal disease is target spot. In some embodiments, the fungal disease is brown rust. In some embodiments, the fungal disease is yellow rust. In some embodiments, the fungal disease is coffee leaf rust. In some embodiments, the fungal disease is Asian soybean rust. In some embodiments, the fungal disease is rust. In some embodiments, the fungal disease is rice blast. In some embodiments, the fungal disease is leaf roll. In some embodiments, the fungal disease is common smut.

[0897] Other fungicides are used to control a wide spectrum of diseases, including fungal diseases as described herein. Other fungicides can be used for a variety of plants, including plants as described herein. Preferably, other fungicides are used to control the following fungal diseases. In some embodiments, the disease is sheath blight in rice crops. In some embodiments, the disease is apple scab. In some embodiments, the disease is early blight in vegetable crops. In some embodiments, the vegetable crop is potato. In some embodiments, the vegetable crop is tomato. In some embodiments, the vegetable crop is pepper. In some embodiments, the disease is anthracnose and / or Alternaria. In some embodiments, the disease is early blight in potato. In some embodiments, the disease is anthracnose in pepper. In some embodiments, the disease is Septoria in cereals. In some embodiments, the disease is black banana leaf spot in banana. In some embodiments, the disease is cucumber powdery mildew in melon. In some embodiments, the disease is anthracnose and / or Alternaria in pepper. In some embodiments, the disease is grape powdery mildew (Erysiphe necator) in grape. In some embodiments, the disease is Phakopsora pachyrhizi in soybeans. In some embodiments, the disease is Botrytis cinerea in strawberries. In some embodiments, the disease is Ventricularia spp. in apples. In some embodiments, the disease is Alternaria species or Phytophthora infestans in tomatoes. In some embodiments, the disease is Peronospora pyrifolia in grapes. In some embodiments, the disease is caused by Colletotrichum capsici. In some embodiments, the disease is caused by Alternaria solani.

[0898] Each embodiment disclosed herein is contemplated to be applicable to each other disclosed embodiment. Therefore, all combinations of the various elements described herein are within the scope of the invention. In addition, the elements listed in the composition embodiments can be used in the combinations, mixtures (including synergistic mixtures), packaging, methods and use embodiments described herein, and vice versa. In addition, the elements listed in the combination embodiments can be used in the compositions, kits, methods and use embodiments described herein, and vice versa.

[0899] The following representative examples illustrate the practice of the present invention in some of its embodiments, but should not be construed as limiting the scope of the present invention in any way. Other embodiments will be apparent to those skilled in the art based on consideration of the specification and examples. It is intended that the specification (including the examples) be considered exemplary and / or illustrative only and not limiting the scope and coverage of the present invention.

[0900] A synergistic effect exists whenever the effect of the combination of active ingredients is greater than the sum of the effects of the individual components.

[0901] In the agricultural field, the term "synergistic effect" is generally understood as defined by Colby SR in an article entitled "Calculation of the synergistic and antagonistic responses of herbicide combinations", published in the magazine Weeds, 1967, 15, pages 20-22. The expected effect for a given combination of active ingredients can be calculated as follows:

[0902]

[0903] The expected effect for a given combination of three active ingredients can be calculated as follows:

[0904]

[0905] Wherein E represents the expected synergistic effect, such as the percentage of pest control, for the combination of active ingredients at a defined dose (e.g., equal to x and y, respectively), X is the effect observed for compound (I) at a defined dose (equal to x), such as the percentage of pest control, and Y is the effect observed for compound (II) at a defined dose (equal to y), such as the percentage of pest control. Here, the efficacy or inhibition percentage is determined in %. 0% means the efficacy corresponding to the control, i.e., as if no treatment was applied. And 100% inhibition percentage means that complete control is observed. When the percentage of control observed for the combination is greater than E, there is a synergistic effect. When the percentage of control observed for the combination is equal to E, there is an additive effect and when the percentage of control observed for the combination is lower than E, there is an antagonistic effect.

[0906] In some embodiments, the combination is used in conjunction with pathogen control. In some embodiments, the combination is used in conjunction with enhancing crop plants. In some embodiments, the combination is used in conjunction with enhancing plant development. In some other embodiments, the combination is used in conjunction with enhancing root systems. In some embodiments, the combination is synergistic and is used to improve plant quality. In some embodiments, the combination is used in conjunction with regulating plant growth. In some embodiments, the combination is used in conjunction with controlling different pathogen species.

[0907] Although the disclosure of the present invention can be easily implemented in various modifications and alternative forms, specific embodiments have been described in detail herein by way of example. However, it should be understood that this disclosure is not intended to be limited to the specific forms disclosed. On the contrary, this disclosure will cover all modifications, equivalents and alternatives and their legal equivalents within the scope of this disclosure as defined by the following claims.

[0908] Representative Examples

[0909] Example 1 - Example of multi-component combination and preparation:

[0910] Composition (1)

[0911] Picoxystrobin 32.5g / L

[0912] Tebuconazole 40g / L

[0913] Mancozeb 300g / L

[0914] Polyphenols (35%) 125g / L

[0915] Copper hydroxide (90%) 7,5 g / L

[0916]

[0917]

[0918] Composition (2)

[0919] Picoxystrobin 32.5g / L

[0920] Tebuconazole 40g / L

[0921] Mancozeb 300g / L

[0922] Polyphenols (35%) 62.5 g / L Copper hydroxide (90%) 7,5 g / L

[0923]

[0924]

[0925] a. Preparation of copper-based component (3) + polyphenol-based component (1)

[0926] i. Adding a polyphenol-based compound (component 1) to a copper-based compound (copper component 3)

[0927] ii. Add propylene glycol

[0928] b. Preparation of multi-component combinations containing protective agents

[0929] iii. Adding a combination of picoxystrobin and tebuconazole (component 2) in an organic solvent and a surfactant under high-speed stirring (e.g., 1500 rpm)

[0930] iv. Add a combination of mancozeb (protectant component 3) and dispersant lignin sulfonate in water under high speed stirring (eg 1500 rpm).

[0931] The order in which the steps are performed is not critical and is presented for illustration purposes only.

[0932] Example 2 - Embodiments of multi-component combinations.

[0933] Composition (3)

[0934] Picoxystrobin / Tebuconazole / Mancozeb / Polyphenol

[0935]

[0936]

[0937] Example 3

[0938] Field trials were conducted in Rio Verde, Goiás state, Brazil, during the 2020 / 2021 growing season. 。

[0939] The soybean variety used for the trial was BMX FOCO (Brasmax Ltd.). It was sown on December 28, 2020 。

[0940] Each fungicide treatment and untreated control consisted of 4 replicates. The size of each experimental plot was 15 m 2 (5x 3m), and the total area of ​​each treatment / non-treatment is 60m 2 The experiment was conducted under a randomized block design.

[0941] Three (3) fungicide treatments were applied during the experimental period, with the first on February 11, 2021, and the second and third applications separated by 15 days.

[0942] The fungicides were applied using a CO2 propellant backpack sprayer equipped with a model XR 110.02 nozzle (TeeJet Co.) and a spray volume of 150 L / ha.

[0943] Evaluations were based on severity of Asian soybean rust at 1 application, 7 days after the 2nd and 3rd applications, and 14 days after the 3rd application.

[0944] Statistical analysis was performed using the Scott-Knott test (hierarchical clustering algorithm used in applied ANOVA).

[0945] Table A. Experimental treatments (untreated and tested products)

[0946]

[0947]

[0948] Based on the results obtained, the area under the disease progression curve (AUDPC) and the corresponding % control were calculated as shown in the following graphs.

[0949] Based on these results, it was observed that the addition of polyphenols + copper (Castorella ellagitannin / copper) boosted the performance of component (2) fungicides picoxystrobin and tebuconazole in the adjuvant methyl soyate (Treatment 2) by 9.5% (Treatment 7) and 10.9% (Treatment 8), respectively.

[0950] It was observed that when picoxystrobin and tebuconazole were added to methyl soyate (treatment 2), the addition of polyphenols + copper reduced the phytotoxicity by about 50% (treatments 7 and 8).

[0951] It was observed that when component (2) fungicides picoxystrobin and tebuconazole were added to the adjuvant methyl soyate (treatment 2), the addition of polyphenols + copper was statistically significant, promoting yield increases of 2.8% (treatment 7) and 5.6% (treatment 8).

[0952] Example 4

[0953] Field trials were carried out in the Valencia region of Goiás state during the 2022 / 2023 growing season.

[0954] Four fungicide spray applications were made with 15 days between sprays.

[0955] Test location: Experimental Station-Beauty / GO;

[0956] Start and end of the trial: January 24, 2023 and April 26, 2023

[0957] Crop: Soybean. Variety: BMX Olimpo IPRO.

[0958] - Planting date: 12 / 12 / 2022;

[0959] - Planting machine: Semeato SHM 11-13;

[0960] -System: No-till

[0961] -Emergence date: December 19, 2022;

[0962] - Plant population: 23.5 plants / m 2 ;

[0963] - Plant density: 235,714 plants / ha;

[0964] - Row spacing: 0.42m;

[0965] - Fertilizer: 00-46-00 (NPK), up to 150kg / ha.

[0966] spray:

[0967] Number of sprays: 4;

[0968] Interval between sprays: 15 days

[0969] Spray method: Land

[0970] Equipment: Backpack CO2 spray

[0971] Spray boom: 5 nozzles XR 110:02WK, 0.5m apart;

[0972] Spray pressure: 30psi;

[0973] Spray speed: 1.5m / s;

[0974] Spray volume: 150L / ha.

[0975] Products used in this study

[0976]

[0977] When polyphenols were added, efficacy against Asian soybean rust was superior (treatments 3 and 4 versus treatment 2 (without polyphenols, see efficacy table 3):

[0978] Table 3 - Results - Severity of Asian rust (Phakoria pachyrhizi) in soybeans (BMX Olimpo IPRO) with different treatments. Beauty / GO, GO, 2023.

[0979]

[0980]

[0981] When polyphenols were added, we could see the benefit of less leaf drop. See Table 4

[0982] Table 4 - Area under the disease progression curve (AUDPC) and leaf drop (%) in soybean (BMX Olimpo IPRO) with different treatments. Beauty / GO, GO, 2023.

[0983]

[0984] In Table 5 we can see a beneficial yield increase of about 200 kg / ha for treatments 3 and 4 (containing polyphenols) relative to treatment No. 2 (without polyphenol-based component):

[0985] Table 5 - Yield (kg / ha) and mass of one thousand kernels (g) of soybeans (BMX Olimpo IPRO) with different treatments. Beauty / GO, GO, 2023.

[0986]

[0987] The benefits of adding polyphenol-based components in terms of plant quality, greener leaves, etc. We noticed a lack of leaves in the control plants, compared to those treated with 2,000 ml / ha and ADA FF 322-22 (three kinds of the same concentration Treatment No. 2, which used 2,000 ml / ha of ADA FF 322-22 (equivalent to adding 22.5 g / L of polyphenols), showed more green leaves. Treatment No. 4, which used 2,000 ml / ha of ADA FF 322-22 (equivalent to adding 22.5 g / L of polyphenols), showed more green leaves. TOV), also resulting in more and greener leaves due to higher anti-rust efficacy + anti-stress and biostimulant effects of polyphenols.

[0988] in conclusion

[0989] The addition of polyphenols to fungicides improves control efficacy against Asian soybean rust and increases yield in terms of kernel weight and total yield and allows, among other things, for reduced fungicide application rates with equal efficacy.

[0990] Example 5 Reduced systemic fungicide / mancozeb ratio

[0991] Typically, the inclusion of a polyphenol-based component can allow for a reduction of about 10%-50% in all fungicide components in the combination without significant loss of fungicidal efficacy and associated plant health benefits.

[0992] During the same trials it was shown that when a polyphenol based component was included / used, the application rates of all fungicides in the tested combinations could be reduced by between 20% and 40%, which was immediately apparent when comparing the efficacy of the composition sprayed at 1.8 L / Ha with the efficacy of the compositions applied at 2.0 L and 2.2 L / Ha.

[0993] During the same trials it was shown that when a polyphenol based component was included / used, the application rate of mancozeb could be significantly reduced by at least 25% from the conventional rate, providing additional formulation and application quality benefits beyond simply reducing costs and environmental impact as explained previously.

[0994] Therefore, compared with the Treatment comparisons showed equal or no loss of efficacy for treatment number 2 relative to treatment numbers 3 to 7 in the table below, where 600 g ia / ha mancozeb was applied together with the polyphenol-based component.

[0995]

[0996]

[0997] See the components of each treatment:

[0998]

[0999] Treatments - Products, active ingredients, concentrations and dosages applied to soybeans (BMX Olimpo IPRO). Beauty / GO, GO / 2023.

[1000]

[1001]

[1002] In treatments 2 to 10, the adjuvant Rumba (soybean oil methyl ester - 765 g / L) was added at a dosage of 0.250 L / ha (191.25 gia / ha).

[1003] Evaluate:

[1004] Biological target: Phakopsora pachyrhizii;

[1005] Parameters evaluated:

[1006] Phytotoxicity - an overall assessment of the plot for symptoms (such as chlorosis or necrosis) resulting from the applied treatment;

[1007] • Severity - Visual record of the percentage (%) of leaf area attacked by the pathogen.

[1008] • Defoliation - Visual record of the percentage (%) of defoliation in the useful area of ​​each experimental plot.

[1009] Productivity - Harvesting the two middle rows of each plot using the Almaco SPC 20 plot harvester, equivalent to 4.54m 2 The volume of the pellets obtained was weighed and their moisture content was determined to estimate the yield.

[1010] • One thousand kernel mass - Three samples of 100 kernels were counted and weighed to estimate the one thousand kernel mass.

[1011] Area under the disease progression curve (AUDPC) :

[1012]

[1013] Yi: disease severity i at the time of evaluation (i=1,...,n);

[1014] Evaluation of the severity of the disease at Yi+1 at i+1;

[1015] Ti: initial assessment time (i);

[1016] Ti+1: time of next evaluation (i+1);

[1017] n = number of evaluations;

[1018] Efficacy calculation: The ABBOTT formula (1925) was used to calculate the percent efficiency resulting from the action of the tested fungicide:

[1019] %E=((TF) / T)x 100

[1020] T = Severity % of control

[1021] F = severity of treatment in %.

[1022] Results and discussion

[1023] The environmental conditions recorded during the experimental time period were: heavy precipitation in December and January before, summer conditions in February and normal conditions in March, with the temperature and relative humidity meeting normal conditions during this time period.

[1024] These conditions, combined with the use of susceptible soybean cultivars and the availability of pathogen inoculum provided by late planting, resulted in the occurrence of natural and high-severity Asian rust.

[1025] The applied fungicide treatments did not cause visual symptoms of phytotoxicity to the soybean plants as observed in evaluations conducted 7 days after each application of the product. (See Table 6)

[1026] Table 6 - Phytotoxicity in soybean (BMX Olimpo IPRO) with different treatments.

[1027]

[1028]

[1029] 1 Means following the same letter in a column are not different from each other by Scott-Knott test (p<0.05).

[1030] Application phase: A-36DAE; B-51DAE; C-66DAE; D-78DAE.

[1031] **Additional in treatments 2 to 10 [Methyl soybean ester] adjuvant (0.250L / ha).

[1032] These results demonstrate the selectivity of BMX Desafio IPRO soybean treatments in foliar applications.

[1033] The first two applications of fungicide treatment were performed preventively and no symptoms of Asian rust were present in the soybean plants. In the evaluation before the third application, the first symptoms of the disease were detected in the experiment, but only in the control treatment without fungicide application. In the next evaluation, before the fourth application, the disease was already present in all treatments and had a significantly higher severity in the control without control, with no differences between the fungicides tested (Table 7).

[1034] Table 7 - Severity of Asian rust (Phakopsora pachyrhizi) in soybeans (BMX Olimpo IPRO) under different treatments.

[1035]

[1036]

[1037] 1 Mean values ​​following the same letter in a column are not different from each other (p<0.05) by Scott-Knott's test. Administration phase: A-36DAE; B-51DAE; C-66DAE; D-78DAE.

[1038] **Additional Rumba [methyl soylate] adjuvant in treatments 2 to 10 (0.250 L / ha).

[1039] In the subsequent severity evaluations conducted at 7, 14, 21, and 28 DAA4, Asian soybean rust developed rapidly and there were greater differences in control efficiency between treatments. All treatments performed very well compared to TOV, and this effect was clearly significant at 7 and 28 DAA4 (Tables 8 and 9). In the specific case of the fungicide ADA FF322-22, it responded to the dose increase, with better results at 2L and 2.2L / ha compared to 1.8L / ha.

[1040] Table 8 - Severity of Asian rust (Phakopsora pachyrhizi) in soybeans (BMX Olimpo IPRO) under different treatments.

[1041]

[1042] 1Means following the same letter in a column are not different from each other by Scott-Knott's test (p<0.05). Application phase: A-36 DAE; B-51 DAE; C-66 DAE; D-78 DAE. **Additional Rumba adjuvant (0.250 L / ha) in treatments 2 to 10.

[1043] Table 9 - Severity of Asian soybean rust in soybeans of different treatments.

[1044]

[1045]

[1046] 1 Means following the same letter in a column are not different from each other by Scott-Knott's test (p<0.05). Application phase: A-36 DAE; B-51 DAE; C-66 DAE; D-78 DAE. **Additional Rumba adjuvant (0.250 L / ha) in treatments 2 to 10.

[1047] AUDPC and defoliation data confirmed these results and showed high control efficiencies in all fungicide treatments, with AUDPC reductions for Asian rust ranging from 76.9% to 80.7% (Table 10). There was a trend toward superiority for the treatments with ADA FF 322-22, ADA FF 316-22, ADA FF 317-22, ADA FF 321-22, ADA FF 318-22, and ADA FF 319-22 compared to the treatments with TOV.

[1048] Table 10 - Area under the curve of disease progression (AACPD) and defoliation (%) in soybean (BMX Olimpo IPRO) with different treatments.

[1049]

[1050]

[1051] 1 Means following the same letter in a column are not different from each other by Scott-Knott's test (p<0.05). Application phase: A-36 DAE; B-51 DAE; C-66 DAE; D-78 DAE. **Additional Rumba adjuvant (0.250 L / ha) in treatments 2 to 10.

[1052] All treatments with fungicide application produced more disease control than the untreated control, with increases ranging from 48.7% to 58.1%. This result was also confirmed by the mass of one thousand kernels, where the treatments with fungicide application produced kernels that were 19.6% to 24.1% heavier. (Table 11).

[1053] Table 11 - Productivity (kg / ha) and mass of one thousand kernels (g) of soybeans (BMX Olimpo IPRO) with different treatments. Beauty / GO, GO, 2023.

[1054]

[1055]

[1056] 1 Means following the same letter in a column are not different from each other by Scott-Knott's test (p<0.05). Application phase: A-36 DAE; B-51 DAE; C-66 DAE; D-78 DAE. **Additional Rumba adjuvant (0.250 L / ha) in treatments 2 to 10.

Claims

1. A multi-component combination comprising at least two components (1) polyphenol-based components; and (2) at least one fungicide (A) selected from the group consisting of: QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof; and optionally, (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper-based compounds; and iii. any and all mixtures thereof; Provided that the polyphenol-based component (1) contains naturally-derived or derived polyphenol-based compounds and that lignin sulfonate, if present in the combination or in a composition comprising the combination, is not the only polyphenol-based compound.

2. A multi-component combination comprising at least two components (1) polyphenol-based components; and (2) at least one fungicide (A) selected from the group consisting of: QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof; and optionally, (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper-based compounds; and iii. any and all mixtures thereof; Provided that the polyphenol-based component (1) contains at least one polyphenol which is not a lignin sulfonate and that the lignin sulfonate, if present in the combination or in a composition comprising the combination, is not the only polyphenol-based compound.

3. A multi-component combination comprising at least two components, (1) polyphenol-based components; and (2) at least one fungicide (A) selected from the group consisting of: (a) QiI fungicide; (b) strobilurin fungicides; (c) succinate dehydrogenase inhibitor (SDHI) fungicides; (d) triazole fungicides; (e) morpholine fungicides; and Any and all mixtures of two or more of (a)-(e); and optionally, (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper-based compounds; and iii. any and all mixtures thereof; wherein the combination is more effective in treating plants or soil against fungal diseases than the same amount of each fungicide when applied alone or as a mixture of fungicides - without the polyphenol-based component, provided that the polyphenol-based component (1) contains a naturally-sourced or derived polyphenol-based compound and lignin sulfonate, if present in the combination or in a composition comprising the combination, is not the only polyphenol-based compound.

4. A multi-component combination comprising at least two components, (1) polyphenol-based components; and (2) at least one fungicide (A) selected from the group consisting of: (a) QiI fungicide; (b) strobilurin fungicides; (c) succinate dehydrogenase inhibitor (SDHI) fungicides; (d) triazole fungicides; (e) morpholine fungicides; and Any and all mixtures of two or more of (a)-(e); and optionally, (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper-based compounds; and iii. any and all mixtures thereof; wherein the combination is more effective in treating plants or soil against fungal diseases than the same amount of each fungicide when applied alone or as a mixture of fungicides - without the polyphenol-based component, provided that the polyphenol-based component (1) contains at least one polyphenol that is not a lignin sulfonate and that lignin sulfonate, if present in the combination or in a composition comprising the combination, is not the only polyphenol-based compound.

5. A multi-component combination comprising at least two components, (1) Polyphenol-based components and As a component (2) at least one fungicide (A) selected from the group consisting of: (a) QiI fungicide; (b) strobilurin fungicides; (c) succinate dehydrogenase inhibitor (SDHI) fungicides; (d) triazole fungicides; (e) morpholine fungicides; and Any and all mixtures of two or more of (a)-(e); and optionally, (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper-based compounds; and iii. any and all mixtures thereof; in, When applied together, an amount of a polyphenol-based component and an amount of said fungicide (A) are more effective in treating plants or soil against fungal infection than when the same amount of each component is applied alone, provided that said polyphenol-based component (1) contains a naturally-sourced or derived polyphenol-based compound and lignin sulfonate, if present in said combination or in a composition comprising said combination, is not the only polyphenol-based compound.

6. A multi-component combination comprising at least two components, (1) Polyphenol-based components and As a component (2) at least one fungicide (A) selected from the group consisting of: (a) QiI fungicide; (b) strobilurin fungicides; (c) succinate dehydrogenase inhibitor (SDHI) fungicides; (d) triazole fungicides; (e) morpholine fungicides; and Any and all mixtures of two or more of (a)-(e); and optionally, (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper-based compounds; and iii. any and all mixtures thereof; in, When applied together, an amount of a polyphenol-based component and an amount of said fungicide (A) are more effective in treating plants or soil against fungal infection than when the same amount of each component is applied alone, provided that said polyphenol-based component (1) contains at least one polyphenol that is not a lignin sulfonate and that lignin sulfonate, if present in said combination or in a composition comprising said combination, is not the only polyphenol-based compound.

7. A multi-component combination comprising at least two components, (1) a polyphenol-based component, and As component (2), at least one fungicide (A) selected from the group consisting of: (a) QiI fungicide, (b) strobilurin fungicides, (c) succinate dehydrogenase inhibitor (SDHI) fungicides, (d) triazole fungicides, and (e) morpholine fungicides; and Any and all mixtures of two or more of (a)-(e); and optionally, (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper-based compounds; and iii. any and all mixtures thereof; in, The amount of said fungicide (A) in said combination is less than the fungicidally effective amount of said fungicide (A) if said fungicide (A) is used alone, provided that said polyphenol-based component (1) contains naturally-derived or derived polyphenol-based compounds and that lignin sulfonate, if present in said combination or in a composition comprising said combination, is not the only polyphenol-based compound.

8. A multi-component combination comprising at least two components, (1) a polyphenol-based component, and (2), at least one fungicide (A) selected from the group consisting of: (a) QiI fungicide, (b) strobilurin fungicides, (c) succinate dehydrogenase inhibitor (SDHI) fungicides, (d) triazole fungicides, and (e) morpholine fungicides; and Any and all mixtures of two or more of (a)-(e); and optionally, (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper based compounds; and iii. any and all mixtures thereof; in, The amount of said fungicide (A) in said combination is less than the fungicidally effective amount of said fungicide (A) if said fungicide (A) is used alone, provided that said polyphenol-based component (1) contains at least one polyphenol that is not a lignin sulfonate and that lignin sulfonate, if present in said combination or in a composition comprising said combination, is not the only polyphenol-based compound.

9. The multi-component combination according to any one of claims 1 to 8, wherein: The combination comprises a polyphenol-based component, a QiI fungicide and an azole fungicide.

10. The multi-component combination according to any one of claims 1 to 8, wherein: The combination comprises a polyphenol-based component, a morpholine fungicide and a SDHI fungicide.

11. The multi-component combination according to any one of claims 1 to 8, wherein: The combination comprises a polyphenol-based component, a morpholine fungicide and a strobilurin fungicide.

12. The multi-component combination according to any one of claims 1 to 8, wherein: The combination comprises a polyphenol-based component, a morpholine fungicide and an azole fungicide.

13. The multi-component combination according to any one of claims 1 to 8, wherein: The combination comprises a polyphenol-based component, a SDHI fungicide and a strobilurin fungicide.

14. The multi-component combination according to any one of claims 1 to 8, wherein: The combination comprises a polyphenol-based component, a morpholine fungicide and a strobilurin fungicide.

15. The multi-component combination according to any one of claims 1 to 8, wherein: The strobilurin is selected from the group consisting of picoxystrobin, trifloxystrobin, azoxystrobin, pyraclostrobin, fenoxystrobin, tetrathiazolin, toluenestrobin, and any combination of two or more thereof.

16. The multi-component combination according to any one of claims 1 to 8, wherein: The QiI fungicide (endoquinone inhibitor) is selected from the group consisting of pyridamole, cyazofamid, indazolesulfamide and any combination thereof.

17. The multi-component combination according to any one of claims 1 to 8, wherein: The SDHI fungicide is selected from the group consisting of penthiopyrad, boscalid, flutolanil, fluopyram, fluopyram, fluindrafenamide, benzovintriazole, bixafen, fluopyram and combinations thereof.

18. The multi-component combination according to any one of claims 1 to 8, wherein: The SDHI is selected from the group consisting of penthiopyrad, boscalid, flutolanil, fluopyram, fluopyram, fluindrafenamide, benzovintriazole, bixafen, fluopyram and any combination thereof.

19. The multi-component combination according to any one of claims 1 to 8, wherein: The triazole fungicide is selected from the group consisting of azaconazole, bifenthrin, bromoconazole, cyproconazole, difenoconazole, diniconazole, fluepiconazole, eticonazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imipenem, picroconazole, metconazole, myclobutanil, penconazole, propiconazole, silyconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, trithionazole, prothioconazole, and any combination of two or more thereof.

20. A multi-component combination as claimed in any one of claims 1 to 19, comprising at least three components, (1) Polyphenol-based components, (2) at least one fungicide (A) selected from the group consisting of QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof, and (3) A compound selected from the following group, i. Protective agent fungicide; ii. Copper based compounds; and iii. Any and all mixtures thereof.

21. The multi-component combination according to any one of claims 1 to 8 and 20, wherein: The protectant fungicide is selected from the group consisting of fluazinam, thiophanate-methyl; (EBDC); dithiocarbamates; mancozeb, sulfur, folpet; captan; maneb; metiram; polycarbamates; propineb; zineb; and any and all mixtures thereof.

22. The multi-component combination of any one of claims 1-8 and 20-21, wherein: The copper-based compound is selected from the group consisting of copper acetate; copper chloride; copper chlorate; copper formate; copper hexafluorosilicate; copper nitrate; copper chromate; copper sulfate pentahydrate; Bordeaux mixture; copper hydroxide; copper oxychlorosulfate; tricopper sulfate; copper sulfate; tricopper hydroxide; hemihydrate; chelated copper; copper chelated with an amino acid; complexed copper; copper glycinate; copper alanate; and any and all combinations thereof; and any and all mixtures thereof.

23. The multi-component combination of any one of claims 1-8 and 20-22, wherein: The copper-based compound is selected from the group consisting of: copper chelated with a chelating agent such as EDTA; copper complexed with an amino acid; copper glycinate; copper alanate; and any and all combinations thereof; and any and all mixtures thereof.

24. The multi-component combination of any one of claims 1-8 and 20-23, wherein: The copper-based compound is selected from the group consisting of: chelated copper; copper complexed with at least one amino acid; and any mixture thereof.

25. The multi-component combination of any one of claims 1-8 and 20-24, wherein: Component (3) comprises a copper-based compound and is free of protectant fungicide compounds.

26. A composition comprising the multi-component combination of any one of claims 1-8 and 20-25, and an agriculturally acceptable carrier.

27. The composition of claim 26, comprising the multi-component combination of claim 25.

28. The multi-component combination of claim 25, or a composition comprising said combination, wherein: The combination has an efficacy comparable to that of the same fungicide (A) in combination with a protectant fungicide compound without the polyphenol-based component (1), wherein the protectant fungicide is selected from the group consisting of fluazinam, thiophanate-methyl; (EBDC); dithiocarbamates; mancozeb, sulfur, folpet; captan; maneb; metiram; polycarbamates; propineb; zineb; and any and all mixtures thereof.

29. The multi-component combination of any one of claims 1-8 and 20-24, or a composition comprising the combination and an agriculturally acceptable carrier, wherein The component (3) comprises a protectant fungicide compound in a reduced amount compared to the "fungicidally effective amount", wherein the combination has comparable or equivalent efficacy to a combination of the same fungicide (A) without the polyphenol-based component (1) and the same protectant fungicide compound in the "fungicidally effective amount".

30. The multi-component combination of claim 29, wherein: The reduced amount of the protectant fungicide compound is no more than about 75% of the "fungicidally effective amount" of the protectant fungicide compound as compared to the "fungicidally effective amount" contained in a combination of the same fungicide (A) and the same protectant fungicide compound having at least equal efficacy without the polyphenol-based component (1).

31. A multi-component combination as claimed in any one of claims 28 to 30, wherein: The efficacy is a fungicidal efficacy.

32. A method for reducing the amount of protectant fungicide required for fungicidal efficacy of a combination with a systemic fungicide selected from the group consisting of: a) QiI fungicides, b) strobilurin fungicides, c) succinate dehydrogenase inhibitor (SDHI) fungicides, d) triazole fungicides, and e) morpholine fungicides; and f) Any and all mixtures of two or more of (a) to (e), wherein said method comprises combining at least one polyphenol-based compound with said systemic fungicide, provided that, i. the polyphenol-based compound comprises a naturally derived or derived polyphenol-based compound, and / or ii. the polyphenol-based compound contains at least one polyphenol which is not a lignin sulfonate, and Lignin sulfonates, if present in the combination or in a composition comprising the combination, are not the only polyphenol-based compounds.

33. A polyphenol based compound for use in reducing the amount of protectant fungicide required for fungicidal efficacy in combination with a systemic fungicide selected from the group consisting of: a) QiI fungicides, b) strobilurin fungicides, c) succinate dehydrogenase inhibitor (SDHI) fungicides, d) triazole fungicides, and e) morpholine fungicides; and f) Any and all mixtures of two or more of (a) to (e), wherein the polyphenol-based compound is combined with the systemic fungicide, provided that, i. the polyphenol-based compound comprises a naturally derived or derived polyphenol-based compound, and / or ii. the polyphenol-based compound contains at least one polyphenol which is not a lignin sulfonate, and Lignin sulfonates, if present in the combination or in a composition comprising the combination, are not the only polyphenol-based compounds.

34. The multi-component combination of claim 20, comprising: a) A composition comprising i) a polyphenol-based component (1), and ii) at least one component (3) compound selected from the group consisting of: protectant fungicides; copper-based compounds; and any and all mixtures thereof, and b) A composition comprising as component (2) a systemic fungicide (A) selected from the group consisting of QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof.

35. The multi-component combination of claim 34, wherein: A composition (a.) comprising a polyphenol-based component (1) and a component (3) compound selected from the group consisting of protectant fungicides; copper-based compounds; and any and all mixtures thereof, suitable for use in combination with one or more compositions (b.) comprising as component (2) a systemic fungicide (A) selected from the group consisting of QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures thereof.

36. The multi-component combination of claim 35, wherein: The adaptation includes one or more of the following: I. providing instructions for combining composition (a.) with one or more compositions (b.), preferably packaged together with composition (a.), for example a package insert or as a label of a package insert or as a sales suggestion for the use of composition (a.), II. providing a composition (a.) comprising as component (3) an amount of a protectant fungicide, a copper-based compound or any and all mixtures thereof, the amount of which is reduced to below the fungicidal efficacy of the compound comprising component (3) without the polyphenol-based component (1), III. Providing a kit comprising composition (a.) together with one or more compositions (b.) IV. Any combination of adaptations I-III, and / or V. Any packaging or composition adaptation having a similar effect in the use of combining composition (a.) with one or more compositions (b.).

37. The multi-component combination of claim 20, comprising: a) A composition comprising: i) a polyphenol-based component (1), and ii) component (3) a copper-based compound; and b) a composition comprising i) a systemic fungicide (A) as component (2), the systemic fungicide being selected from the group consisting of QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof, and ii) Component (3) a protectant fungicide compound selected from the group consisting of fluazinam, thiophanate-methyl; (EBDC); dithiocarbamates; mancozeb, sulphur, folpet; captan; maneb; metiram; polycarbamates; propineb; zineb; and any and all mixtures thereof.

38. The multi-component combination of claim 37, wherein: A composition (a.) comprising a component (1) based on polyphenols and a component (3) based on copper, suitable for use in combination with one or more compositions (b.) comprising as component (2) a systemic fungicide (A) selected from the group consisting of: QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures thereof of two or more thereof, and a component (3) protectant fungicide compound selected from the group consisting of: fluazinam, thiophanate-methyl; (EBDC); dithiocarbamates; mancozeb, sulfur, folpet; captan; maneb; metiram; polycarbamates; propineb; zineb; and any and all mixtures thereof.

39. The multi-component combination of claim 38, wherein: The adaptation includes one or more of the following: I. providing instructions for combining composition (a.) with one or more compositions (b.), preferably packaged or supplied together with composition (a.), for example a package insert or as a label or as a sales suggestion for using said composition (a.); II. providing a composition (a.) comprising as component (3) an amount of a copper-based compound, the amount of which is reduced to below the fungicidal efficacy of the copper-based compound comprising component (3) when mixed with a composition (b.) comprising as component (2) a systemic fungicide (A) and as component (3) a protectant fungicide compound without a polyphenol-based component (1); III. Providing a kit comprising composition (a.) together with one or more compositions (b.) IV. Any combination of I-III, or V. Any packaging or composition adaptation having a similar effect in the use of combining composition (a.) with one or more compositions (b.).

40. The composition (a.) of claim 34, comprising a component (1) based on polyphenols and a component (3) compound selected from the group consisting of: protectant fungicides; copper-based compounds; and any and all mixtures thereof, adapted for use in combination with one or more of, i. A composition (b1.) comprising as component (2) a systemic fungicide (A) selected from the group consisting of: QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof, or ii. A composition (b2.) comprising as component (2) a systemic fungicide (A) selected from the group consisting of: QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures thereof of two or more thereof, and as component (3) a protectant fungicide compound selected from the group consisting of: fluazinam, thiophanate-methyl; (EBDC); dithiocarbamates; mancozeb, sulfur, folpet; captan; maneb; metiram; polycarbamates; propineb; zineb; and any and all mixtures thereof.

41. The composition (a.) of claim 37, comprising a polyphenol-based component (1) and a copper-based compound of component (3), adapted for combination with one or more compositions (b.) selected from the group consisting of, i. A composition (b1.) comprising as component (2) a systemic fungicide (A) selected from the group consisting of: QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof, or ii. A composition (b2.) comprising as component (2) a systemic fungicide (A) selected from the group consisting of: QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures thereof of two or more thereof, and as component (3) a protectant fungicide compound selected from the group consisting of: fluazinam, thiophanate-methyl; (EBDC); dithiocarbamates; mancozeb, sulfur, folpet; captan; maneb; metiram; polycarbamates; propineb; zineb; and any and all mixtures thereof.

42. The composition (a.) according to any one of claims 40 or 41, wherein The adaptation includes one or more of the following: I. providing instructions for combining composition (a.) with one or more compositions (b.), preferably packaged together with composition (a.), for example a package insert or as a label or as a sales suggestion for the use of said composition (a.); II. providing a composition (a.) comprising as component (3) an amount of a copper-based compound which is reduced to below the fungicidally effective amount of the copper-based compound comprising component (3) when mixed with a composition (b.) comprising as component (2) a systemic fungicide (A) and as component (3) a protectant fungicide compound without a polyphenol-based component (1); III. Providing a kit comprising composition (a.) together with one or more compositions (b.) IV. Any combination of I-III, or V. Any packaging or composition adaptation having a similar effect in the use of combining composition (a.) with one or more compositions (b.).

43. A multi-component combination as described in any one of claims 1 to 38, wherein: The combination or a composition containing the combination is fungicidally or bactericidally effective, such as any of the following: applied therapeutically, treated therapeutically, having therapeutic activity, applied as a protectant, treated prophylactically, having prophylactic activity, and any and all combinations thereof.

44. A method of improving the fungicidal performance of a composition comprising a combination of picoxystrobin and tebuconazole, the method comprising adding at least one polyphenol-based compound and at least one copper-based compound to the composition comprising a combination of picoxystrobin and tebuconazole.

45. A method of reducing phytotoxicity associated with fungicidal treatment with a composition comprising a combination of picoxystrobin and tebuconazole, the method comprising adding at least one polyphenol-based compound and at least one copper-based compound to the composition comprising a combination of picoxystrobin and tebuconazole.

46. ​​A method of increasing plant yield associated with fungicidal treatment with a composition comprising a combination of picoxystrobin and tebuconazole, the method comprising adding at least one polyphenol-based compound and at least one copper-based compound to the composition comprising a combination of picoxystrobin and tebuconazole.

47. The method of any one of claims 32 and 44-46, wherein: The at least one polyphenol-based compound is selected from the group comprising: chestnut ellagitannins; extracts of water-soluble tannins; extracts of water-soluble proanthocyanidins; and combinations thereof, alone or together with other polyphenolic compounds of natural origin.

48. The method of any one of claims 32 and 44-47, wherein: Compositions comprising the combinations for use in the methods include adjuvants.

49. The method of claim 48, wherein: The adjuvant includes methyl soybean ester.

50. A multi-component combination comprising, (1) a certain amount of a polyphenol-based component, (2) an amount of at least one fungicide (A) selected from the group consisting of: QiI fungicide; strobilurin fungicides (QoI); SDHI fungicide; Azole fungicides (DMI); and morpholine fungicides, and (3) at least one compound selected from the following group, Fluazifop; Thiophanate; Mancozeb; sulfur; Felting pill; Captan; and Copper-based compounds, The fungicide (A) wherein said amount of polyphenol-based component (1) and said amount of component (2) if applied together is more effective in treating and / or protecting plants or soil against fungal and / or bacterial infection than applying the same amount of each component alone.

51. The multi-component combination of claim 50, wherein: The amount of component (3) compound in the combination is reduced compared to a fungicidally effective combination without the polyphenol-based component, comprising the same amount of the same component (2) combined with the same component (3) compound, wherein the multi-component combination is characterized by equal or superior fungicidal activity and reduced incidence of phytotoxicity.

52. A multi-component combination comprising at least three components, (1) Polyphenol-based components, (2) strobilurin and / or triazole (DMI) systemic fungicide components, and (3) ethylene bisdithiocarbamate (EBDC) fungicide component, wherein the EBDC fungicide content is reduced by 25% or more compared to a fungicidally effective amount of the EBDC fungicide when applied with the same systemic fungicide without the polyphenol-based component, without loss of activity or reduction in efficacy.

53. The multi-component combination of claim 52, comprising (1) Polyphenol-based components, (2) strobilurin and / or triazole systemic fungicide components, (3) an ethylenebisdithiocarbamate (EBDC) fungicide component, and 50 g / ha or less of a copper-based compound, wherein the combination is characterized by enhanced fungicidal efficacy compared to a combination of the same component (1) polyphenol-based compound, the same component (2) systemic fungicide, and the same component (3) EBDC fungicide without the copper-based compound.

54. A multi-component combination as described in any one of claims 1 to 8, wherein The polyphenol-based component is one or more of the following: phenolic acids; stilbenes; lignans; hydrolyzable tannins; tannic acid; lignin; flavonoids; flavones, aurone, anthocyanins, anthocyanins; flavonols; flavanols; Flavanones; chalcones; isoflavones; proanthocyanidins, and extracts comprising at least one polyphenolic structure / source, such as water-soluble tannins and proanthocyanidins.

55. A multi-component combination as described in any one of claims 1 to 8, comprising (1) Polyphenol-based components, (2) Systemic fungicide components, (3) Protective fungicides and copper-based compounds, in, The protectant fungicide is selected from the group consisting of fluazinam; thiophanate-methyl; mancozeb; sulfur; folpet; captan and combinations thereof.

56. A multi-component combination as described in any one of claims 1 to 8, comprising, (1) Polyphenol-based components, (2) Systemic fungicide components, (3) Copper-based compounds, wherein the copper-based compound is one or more of: copper acetate; copper chloride; copper chlorate; copper formate; copper hexafluorosilicate; copper nitrate; copper chromate; copper sulfate pentahydrate; Bordeaux mixture; copper hydroxide; copper oxychlorosulfate (COCS); tricopper sulfate such as copper sulfate; tricopper hydroxide hemihydrate; copper chelated (or complexed) with EDTA; copper chelated or complexed with amino acids; copper chelated and / or complexed with both EDTA and amino acids; copper glycinate; copper alanate; and any and all combinations thereof.

57. A multi-component combination as described in any one of claims 1 to 8, wherein The copper-based compound is one or more of a copper complex and / or a chelated copper compound.

58. A method of enhancing the fungicidal effect of a systemic fungicide (A), the method comprising combining the fungicide with a polyphenolic compound and less than 50 g / ha of a copper-based compound, wherein the systemic fungicide is selected from the group consisting of QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof, characterized in that The copper-based compound is not in a fungicidally effective amount and the combination has minimal or no phytotoxic effects.

59. A multi-component combination as described in any one of claims 1 to 8, wherein: The combination comprises a combination independently selected from the following groups, Polyphenol-based components and QiI fungicides; polyphenol-based components and azole fungicides; polyphenol-based components and morpholine fungicides; Polyphenol-based components and SDHI fungicides; Polyphenol-based components and strobilurin fungicides; Polyphenol-based components, QiI fungicides, and azole fungicides; polyphenol-based components, morpholine fungicides, and SDHI fungicides; polyphenol-based components, morpholine fungicides, and strobilurin fungicides; polyphenol-based components, morpholine fungicides, and azole fungicides; polyphenol-based components, SDHI fungicides, and strobilurin fungicides; polyphenol-based components, morpholine fungicides, and strobilurin fungicides; polyphenol-based components, QiI fungicides, azole fungicides, and protectant fungicides; polyphenol-based components, morpholine fungicides, SDHI, and protectant fungicides; polyphenol-based components, morpholine fungicides, strobilurin fungicides, and protectant fungicides; polyphenol-based components, morpholine fungicides, azole fungicides, and protectant fungicides; polyphenol-based components, SDHI fungicides, strobilurin fungicides, and protectant fungicides; polyphenol-based components, morpholine fungicides, strobilurin fungicides, and protectant fungicides; Polyphenol-based components, QiI fungicides, and protectant fungicides; polyphenol-based components, azole fungicides, and protectant fungicides; polyphenol-based components, morpholine fungicides, and protectant fungicides; polyphenol-based components, SDHI fungicides, and protectant fungicides; polyphenol-based components, strobilurin fungicides, and protectant fungicides; Polyphenol-based components, copper-based compounds, and QiI fungicides; polyphenol-based components, copper-based compounds, and azole fungicides; Polyphenol-based ingredients, copper-based compounds and morpholine fungicides polyphenol-based components, copper-based compounds, and SDHI fungicides; polyphenol-based components, copper-based compounds, and strobilurin fungicides; Polyphenol-based components, copper-based compounds, QiI fungicides, and azole fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, and SDHI fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, and strobilurin fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, and azole fungicides; polyphenol-based components, copper-based compounds, SDHI fungicides, and strobilurin fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, and strobilurin fungicides; polyphenol-based components, copper-based compounds, QiI fungicides, azole fungicides, and protectant fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, SDHI, and protectant fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, strobilurin fungicides, and protectant fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, azole fungicides, and protectant fungicides; polyphenol-based components, copper-based compounds, SDHI fungicides, strobilurin fungicides, and protectant fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, strobilurin fungicides, and protectant fungicides; polyphenol-based components, copper-based compounds, QiI fungicides, and protectant fungicides; polyphenol-based components, copper-based compounds, azole fungicides, and protectant fungicides; polyphenol-based components, copper-based compounds, morpholine fungicides, and protectant fungicides; polyphenol-based components, copper-based compounds, SDHI fungicides, and protectant fungicides; and Polyphenol-based components, copper-based compounds, strobilurin fungicides and protectant fungicides, Wherein, the azole fungicide is selected from one or more of the following: azaconazole, bifenthrin, bromoconazole, cyproconazole, difenoconazole, diniconazole, fluepiconazole, eticonazole, nitrobenazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imipenem, cyproconazole, metconazole, myclobutanil, penconazole, propiconazole, silyfloxacin, tebuconazole, tetraconazole, triadimefon, triadimenol, trithionazole, prothioconazole, clofoconazole, Wherein, the strobilurin fungicide is selected from one or more of the following: azoxystrobin, syringystrobin, enoxastrobin, flutoxifen, picoxystrobin, pyraclostrobin, toluenestrobin, pyraclostrobin, pyraclostrobin, pyraclostrobin, chlorpyrifos, kresoxim-methyl, trifloxystrobin, doxystrobin, enoxastrobin, fenoxystrobin, oxadiazine, tetrazobactam and fluoxastrobin, Wherein, the SDHI fungicide is selected from one or more of the following: penthiopyrad, boscalid, flutolanil, fluopyram, indopyram, fluopyram, fluindrafenamide, benzovintriazole, bixafen, fluopyram, Wherein, the QiI fungicide is selected from one or more of the following: cyazofamid, indazolesulfamide, pyridamole, Wherein, the morpholine fungicide is selected from one or more of the following: 4-dodecyl-2,6-dimethylmorpholine, antifungal, morpholine, methacryloylmorpholine, fenpropimorph, flumorph, tridemorph, tricromamide, dodecamorph, spiroxafil, powdery mildew, fenpropidin, and Wherein, the protective agent fungicide is selected from one or more of the following: mancozeb, sulfur, folpet, captan, captaptan, fluazinam, thiophanate-methyl, dithiocarbamate, mancozeb, propineb, and maneb.

60. The multi-component combination of any one of claims 1 to 8, wherein: The combination is independently selected from the following groups, polyphenol-based fractions, picoxystrobin, tebuconazole, and Bordeaux mixture; polyphenol-based fractions, picoxystrobin, tebuconazole, and fluazinam; polyphenol-based components, picoxystrobin, tebuconazole, and folpet; polyphenol-based fractions, picoxystrobin, tebuconazole, and sulfur; polyphenol-based components, picoxystrobin, prothioconazole, and mancozeb; polyphenol-based components, picoxystrobin, prothioconazole, and copper oxychloride; polyphenol-based components, picoxystrobin, prothioconazole, and copper hydroxide; polyphenol-based fractions, picoxystrobin, prothioconazole, and Bordeaux mixture; polyphenol-based components, picoxystrobin, prothioconazole, and fluazinam; polyphenol-based components, picoxystrobin, prothioconazole, and captan; polyphenol-based components, picoxystrobin, prothioconazole, and folpet; polyphenol-based components, picoxystrobin, prothioconazole, and sulfur; polyphenol-based fractions, fluopicolide, tebuconazole, and mancozeb; polyphenol-based fractions, fluopicolide, tebuconazole, and copper oxychloride; polyphenol-based components, fluopyrabamide, tebuconazole, and copper hydroxide; polyphenol-based fractions, fluopicolide, tebuconazole, and Bordeaux mixture; polyphenol-based fractions, fluopicolide, tebuconazole, and fluazinam; polyphenol-based fractions, fluopicolide, tebuconazole, and thiophanate-methyl; polyphenol-based fractions, fluopicolide, tebuconazole, and captan; polyphenol-based components, fluopicolide, tebuconazole, and folpet; polyphenol-based components, fluopyrabamide, tebuconazole, and sulfur; polyphenol-based components, fluopyrabamide, prothioconazole, and mancozeb; polyphenol-based components, fluopyrabamide, prothioconazole, and copper oxychloride; polyphenol-based components, fluopyrabamide, prothioconazole, and copper hydroxide; polyphenol-based fractions, fluopyrabamide, prothioconazole, and Bordeaux mixture; polyphenol-based components, fluopyrabendazim, prothioconazole, and fluazinam; polyphenol-based components, fluopicolide, prothioconazole, and thiophanate-methyl; polyphenol-based components, fluopyrabamide, prothioconazole, and captan; polyphenol-based components, fluopicolide, prothioconazole, and folpet; polyphenol-based components, fluopyrabamide, prothioconazole, and sulfur; polyphenol-based components, picoxystrobin, fenpropidin, and mancozeb; polyphenol-based components, picoxystrobin, fenpropidin, and copper oxychloride; polyphenol-based components, picoxystrobin, fenpropidin, and copper hydroxide; polyphenol-based fractions, picoxystrobin, fenpropidin, and Bordeaux mixture; polyphenol-based components, picoxystrobin, fenpropidin, and fluazinam; polyphenol-based components, picoxystrobin, fenpropidin, and thiophanate-methyl; polyphenol-based components, picoxystrobin, fenpropidin, and captan; polyphenol-based components, picoxystrobin, fenpropidin, and folpet; polyphenol-based components, picoxystrobin, fenpropidin, and sulfur; polyphenol-based components, fluopicolide, fenpropidin, and mancozeb; polyphenol-based components, fluopyram, fenpropidin, and copper oxychloride; polyphenol-based components, fluopyram, fenpropidin, and copper hydroxide; polyphenol-based fractions, fluopicolide, fenpropidin, and Bordeaux mixture; polyphenol-based components, fluopyram, fenpropidin, and fluazinam; polyphenol-based components, fenpropidin, fluopicolide, and thiophanate-methyl; polyphenol-based components, fluopicolide, fenpropidin, and captan; polyphenol-based components, fluopicolide, fenpropidin, and folpet; polyphenol-based components, fluopyram, fenpropidin, and sulfur; polyphenol-based components, prothioconazole, fenpropidin, and mancozeb; polyphenol-based components, prothioconazole, fenpropidin, and copper oxychloride; polyphenol-based components, prothioconazole, fenpropidin, and copper hydroxide; polyphenol-based fractions, prothioconazole, fenpropidin, and Bordeaux mixture; polyphenol-based components, prothioconazole, fenpropidin, and fluazinam; polyphenol-based components, prothioconazole, fenpropidin, and thiophanate-methyl; polyphenol-based components, prothioconazole, fenpropidin, and captan; polyphenol-based components, prothioconazole, fenpropidin, and folpet; polyphenol-based components, prothioconazole, fenpropidin, and sulfur; polyphenol-based fractions, tebuconazole, fenpropidin, and mancozeb; polyphenol-based fractions, tebuconazole, fenpropidin, and cupric oxychloride; polyphenol-based components, tebuconazole, fenpropidin, and copper hydroxide; polyphenol-based fractions, tebuconazole, fenpropidin, and Bordeaux mixture; polyphenol-based fractions, tebuconazole, fenpropidin, and fluazinam; polyphenol-based fractions, tebuconazole, fenpropidin, and thiophanate-methyl; polyphenol-based fractions, tebuconazole, fenpropidin, and captan; polyphenol-based components, tebuconazole, fenpropidin, and folpet; polyphenol-based components, tebuconazole, fenpropidin, and sulfur; polyphenol-based fractions, azoxystrobin, difenoconazole, and thiophanate-methyl; polyphenol-based fractions, cyproconazole, mancozeb, and tetrazopyralid; polyphenol-based fractions, cyproconazole, mancozeb, and tetrazopyralid; polyphenol-based components, mancozeb, cyproconazole, and tetrazopyralid; polyphenol-based components, mancozeb, cyproconazole, and picoxystrobin; polyphenol-based fractions, mancozeb, cyproconazole, and fluopicolide; polyphenol-based components, mancozeb, cyproconazole, and azoxystrobin; polyphenol-based components, mancozeb, cyproconazole, and trifloxystrobin; polyphenol-based components, mancozeb, cyproconazole, and pyraclostrobin; polyphenol-based components, mancozeb, cyproconazole, and fenoxystrobin; polyphenol-based components, mancozeb, cyproconazole, and bixafen; polyphenol-based components, mancozeb, cyproconazole, and indopyraclostrobin; polyphenol-based components, mancozeb, cyproconazole, and fluinoxam; polyphenol-based components, mancozeb, cyproconazole, and benzotriazole; polyphenol-based components, mancozeb, cyproconazole, and pentoconazole; polyphenol-based components, mancozeb, difenoconazole, and tetracycline; polyphenol-based components, mancozeb, difenoconazole, and picoxystrobin; polyphenol-based components, mancozeb, difenoconazole, and fluopicolide; polyphenol-based components, mancozeb, difenoconazole, and azoxystrobin; polyphenol-based components, mancozeb, difenoconazole, and trifloxystrobin; polyphenol-based components, mancozeb, difenoconazole, and pyraclostrobin; polyphenol-based components, mancozeb, difenoconazole, and fenoxystrobin; polyphenol-based components, mancozeb, difenoconazole, and bixafen; polyphenol-based components, mancozeb, difenoconazole, and indopyraclostrobin; polyphenol-based components, mancozeb, difenoconazole, and flufenoxam; polyphenol-based components, mancozeb, difenoconazole, and benzotriazole; polyphenol-based components, mancozeb, difenoconazole, and pentocyclamide; polyphenol-based components, mancozeb, difenoconazole, and pyridoxamide; polyphenol-based components, mancozeb, cyfluthrin, and tetracycline; polyphenol-based components, mancozeb, fluazifop-butyl, and picoxystrobin; polyphenol-based components, mancozeb, fluopicolide, and trifloxystrobin; polyphenol-based components, mancozeb, cyfluthrin, and azoxystrobin; polyphenol-based components, mancozeb, fluazifop-butyl, and trifloxystrobin; polyphenol-based components, mancozeb, cyfluthrin, and pyraclostrobin; polyphenol-based components, mancozeb, cyfluthrin, and fenoxystrobin; polyphenol-based components, mancozeb, fluazifop-dopamine, and bixafen; polyphenol-based components, mancozeb, fluazifop-dopamide, and indopyraclostrobin; polyphenol-based components, mancozeb, fluazifop-dopamine, and flufenoxam; polyphenol-based components, mancozeb, fluazifop, and benzotriazole; polyphenol-based components, mancozeb, fluopicolide, and pentocyclamide; polyphenol-based components, mancozeb, cyfluthrin, and pyridoxam; Polyphenol-based components, mancozeb, difenoconazole and pyridoxam; Polyphenol-based components, mancozeb, fluazifop-dinitroprop-4-yl and tetracycline; Polyphenol-based components, mancozeb, fluazifop-dinitroprop-4-yl and picoxystrobin; Polyphenol-based components, mancozeb, fluazifop-dinitroprop-4-yl and flupyraclostrobin; Polyphenol-based components, mancozeb, fluazifop-dinitroprop-4-yl and flupyraclostrobin; polyphenol-based components, mancozeb, fluazifop-butyl, and trifloxystrobin; Polyphenol-based components, mancozeb, fluazifop-diffusion and pyraclostrobin; Polyphenol-based components, mancozeb, fluazifop-diffusion and pyraclostrobin; Polyphenol-based components, mancozeb, fluazifop-diffusion and bixafen; Polyphenol-based components, mancozeb, fluazifop-diffusion and indopyram Polyphenol-based components, mancozeb, fluazifop-diffusion and fluindazopyram; Polyphenol-based components, mancozeb, fluazifop-diffusion and benzovintriazole; Polyphenol-based components, mancozeb, fluazifop-diffusion and fluoxazopyram; Polyphenol-based components, mancozeb, fluazifop-diffusion and fluoxazopyram; Polyphenol-based components, mancozeb, fluazifop-diffusion and pyraclostrobin; Polyphenol-based components, mancozeb, fluazifop-diffusion and pyraclostrobin; Polyphenol-based components, mancozeb, prothioconazole and pyraclostrobin; Polyphenol-based components, mancozeb, prothioconazole and tetrazopyram; polyphenol-based components, mancozeb, prothioconazole, and picoxystrobin; polyphenol-based components, mancozeb, prothioconazole, and fluopyrabdo; polyphenol-based components, mancozeb, prothioconazole, and azoxystrobin; polyphenol-based components, mancozeb, prothioconazole, and trifloxystrobin; polyphenol-based components, mancozeb, prothioconazole, and pyraclostrobin; polyphenol-based components, mancozeb, prothioconazole, and fenthiopyrad; Polyphenol-based components, mancozeb, prothioconazole, and bixafen; Polyphenol-based components, mancozeb, prothioconazole, and indopamidol; Polyphenol-based components, mancozeb, prothioconazole and flutoxacillin; Polyphenol-based components, mancozeb, prothioconazole and flutoxacillin; Polyphenol-based components, mancozeb, prothioconazole and flutoxacillin; Polyphenol-based components, mancozeb, prothioconazole and pyridine; Polyphenol-based components, mancozeb, prothioconazole and pyridine; polyphenol-based components, mancozeb, prothioconazole, and tetrazopyrazone; polyphenol-based fractions, mancozeb, tebuconazole, and fluopicolide; polyphenol-based components, mancozeb, prothioconazole, and fluopyrabdo; polyphenol-based fractions, mancozeb, tebuconazole, and azoxystrobin; polyphenol-based fractions, mancozeb, tebuconazole, and trifloxystrobin; polyphenol-based components, mancozeb, tebuconazole, and pyraclostrobin; polyphenol-based components, mancozeb, tebuconazole, and fenthiopyrad; polyphenol-based components, mancozeb, tebuconazole, and bixafen; polyphenol-based fractions, mancozeb, tebuconazole, and indopamidol; polyphenol-based components, mancozeb, tebuconazole, and fluinoxam; polyphenol-based components, mancozeb, tebuconazole, and benzotriazole; polyphenol-based components, mancozeb, prothioconazole, and fluopicolide; polyphenol-based components, mancozeb, prothioconazole, and pyridobactamide; polyphenol-based fractions, mancozeb, tebuconazole, and toluenestrobin; Polyphenol-based ingredients, mancozeb, tebuconazole and tetrazoclostrobin polyphenol-based components, mancozeb, tebuconazole, and pentoconazole; polyphenol-based components, cyproconazole, copper-based compounds, and tetrazopyrazone; polyphenol-based components, cyproconazole, copper-based compounds, and tetrazopyrazone; polyphenol-based components, copper-based fungicides, cyproconazole-tetracycline; polyphenol-based components, copper-based fungicides, cyproconazole, and picoxystrobin; polyphenol-based components, copper-based fungicides, cyproconazole, and trifloxystrobin; polyphenol-based components, copper-based fungicides, cyproconazole, and azoxystrobin; polyphenol-based components, copper-based fungicides, cyproconazole, and trifloxystrobin; polyphenol-based components, copper-based fungicides, cyproconazole, and pyraclostrobin; polyphenol-based components, copper-based fungicides, cyproconazole, and fenoxystrobin; polyphenol-based components, copper-based fungicides, cyproconazole, and bixafen; polyphenol-based components, copper-based fungicides, cyproconazole, and indopamidol; polyphenol-based components, copper-based fungicides, cyproconazole, and fluinoxam; Polyphenol-based ingredients, copper-based fungicides, cyproconazole and benzotriazole polyphenol-based components, copper-based fungicides, cyproconazole, and pentocyclamide; polyphenol-based components, copper-based fungicides, difenoconazole, and tetrazoclostrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and picoxystrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and trifloxystrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and azoxystrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and trifloxystrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and pyraclostrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and fenoxystrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and bixafen; polyphenol-based components, copper-based fungicides, difenoconazole, and indopyraclostrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and flufenoxam; polyphenol-based components, copper-based fungicides, difenoconazole, and benzotriazole; polyphenol-based components, copper-based fungicides, difenoconazole, and pentocyclamide; polyphenol-based components, copper-based fungicides, difenoconazole, and pyraclostrobin; polyphenol-based components, copper-based fungicides, clofopyralid and tetrazopyridamole; polyphenol-based components, copper-based fungicides, clofosconazole, and picoxystrobin; polyphenol-based components, copper-based fungicides, clofopyralid, and trifloxystrobin; polyphenol-based components, copper-based fungicides, clofosconazole, and azoxystrobin; polyphenol-based components, copper-based fungicides, clofosconazole, and trifloxystrobin; polyphenol-based components, copper-based fungicides, cyfluthrin and pyraclostrobin; polyphenol-based components, copper-based fungicides, clofosconazole, and fenoxystrobin; polyphenol-based components, copper-based fungicides, cyfluthrin, and bixafen; polyphenol-based components, copper-based fungicides, cyfluthrin, and indopamidol; polyphenol-based components, copper-based fungicides, fluopicolide, and flufenoxam; polyphenol-based components, copper-based fungicides, fluazifop-dopamidol, and benzotriazole; polyphenol-based components, copper-based fungicides, fluopicolide, and pentocyclamide; polyphenol-based components, copper-based fungicides, clofosconazole, and pyraclostrobin; polyphenol-based components, copper-based fungicides, difenoconazole, and pyraclostrobin; polyphenol-based components, copper-based fungicides, clofopyralid and tetrazopyridamole; polyphenol-based components, copper-based fungicides, clofosconazole, and picoxystrobin; polyphenol-based components, copper-based fungicides, clofopyralid, and trifloxystrobin; polyphenol-based components, copper-based fungicides, clofosconazole, and azoxystrobin; polyphenol-based components, copper-based fungicides, clofosconazole, and trifloxystrobin; polyphenol-based components, copper-based fungicides, cyfluthrin and pyraclostrobin; polyphenol-based components, copper-based fungicides, clofosconazole, and fenoxystrobin; polyphenol-based components, copper-based fungicides, cyfluthrin, and bixafen; polyphenol-based components, copper-based fungicides, cyfluthrin, and indopamidol; polyphenol-based components, copper-based fungicides, fluopicolide, and flufenoxam; polyphenol-based components, copper-based fungicides, fluazifop-dopamidol, and benzotriazole; polyphenol-based components, copper-based fungicides, fluopicolide, and pentocyclamide; polyphenol-based components, copper-based fungicides, clofosconazole, and pyraclostrobin; polyphenol-based components, copper-based fungicides, prothioconazole, and pyridobactamide; polyphenol-based components, copper-based fungicides, prothioconazole, and tetrazoclostrobin; polyphenol-based components, copper-based fungicides, prothioconazole, and picoxystrobin; polyphenol-based components, copper-based fungicides, prothioconazole, and fluopyrabdo; polyphenol-based components, copper-based fungicides, prothioconazole, and azoxystrobin; polyphenol-based components, copper-based fungicides, prothioconazole, and trifloxystrobin; polyphenol-based components, copper-based fungicides, prothioconazole, and pyraclostrobin; polyphenol-based components, copper-based fungicides, prothioconazole, and fenthiocarb; polyphenol-based components, copper-based fungicides, prothioconazole, and bixafen; polyphenol-based components, copper-based fungicides, prothioconazole, and indopamidol; polyphenol-based components, copper-based fungicides, prothioconazole, and fluinoxam; polyphenol-based components, copper-based fungicides, prothioconazole, and benzovintriazole; polyphenol-based components, copper-based fungicides, prothioconazole, and fluopicolide; polyphenol-based components, copper-based fungicides, prothioconazole, and pyridobactamide; polyphenol-based components, copper-based fungicides, tebuconazole, and picoxystrobin; polyphenol-based components, copper-based fungicides, tebuconazole, and pyridobactamide; polyphenol-based components, copper-based fungicides, prothioconazole, and tetrazoclostrobin; polyphenol-based components, copper-based fungicides, tebuconazole, and picoxystrobin; polyphenol-based components, copper-based fungicides, tebuconazole, and fluopicolide; polyphenol-based components, copper-based fungicides, prothioconazole, and fluopyrabdo; polyphenol-based components, copper-based fungicides, tebuconazole, and azoxystrobin; polyphenol-based components, copper-based fungicides, tebuconazole, and trifloxystrobin; polyphenol-based components, copper-based fungicides, tebuconazole, and pyraclostrobin; polyphenol-based components, copper-based fungicides, tebuconazole, and fenoxystrobin; polyphenol-based components, copper-based fungicides, tebuconazole, and bixafen; polyphenol-based components, copper-based fungicides, tebuconazole, and indopamidol; polyphenol-based components, copper-based fungicides, tebuconazole, and fluinoxam; polyphenol-based components, copper-based fungicides, tebuconazole, and benzovinfluazide; polyphenol-based components, copper-based fungicides, prothioconazole, and fluopicolide; polyphenol-based components, copper-based fungicides, prothioconazole, and pyridobactamide; polyphenol-based components, copper-based fungicides, tebuconazole, and toluenestrobin; polyphenol-based components, copper-based fungicides, tebuconazole, and tetrazopyrazone; and Polyphenol-based ingredients, copper-based fungicides, tebuconazole and fluopicolide, The polyphenol-based component comprises a combined extract of natural water-soluble tannins and / or proanthocyanidins or a derivative thereof.

61. A multi-component combination as described in any one of claims 1 to 8, wherein: The combination is one or more selected from combinations 1 to 1792 as defined in Table 1, wherein in each selected combination, the polyphenol-based component (1) is one or more of the following: phenolic acids; stilbenes; lignans; hydrolyzable tannins; tannic acid; lignin; flavonoids; Chestnut ellagitannins; extract of water-soluble tannins; Extracts of water-soluble proanthocyanidins; Combined extracts of natural water-soluble tannins and / or proanthocyanidins, and derivatives of extracts of natural water-soluble tannins and / or proanthocyanidins; Table 1 。 62. A multi-component combination as described in any one of claims 59 to 61, wherein In each selected combination, when present, the copper-based component (3) is one or more of: copper acetate; copper chloride; copper chlorate; copper formate; copper hexafluorosilicate; copper nitrate; copper chromate; copper sulfate pentahydrate; Bordeaux mixture; copper hydroxide; copper oxychlorosulfate (COCS); tricopper sulfate such as copper sulfate; tricopper hydroxide; hemihydrate; copper chelated or complexed with EDTA; copper chelated or complexed with amino acids; copper chelated / complexed with both EDTA and amino acids; copper glycinate and copper alanate.

63. The multi-component combination of claim 62, wherein: In each selected combination, when present, the copper-based component (3) is one or more of: copper chelated or complexed with EDTA; copper chelated or complexed with amino acids; copper chelated or complexed with both EDTA and amino acids; copper glycinate and copper alanate in an agriculturally acceptable carrier.

64. A multi-component combination as described in any one of claims 1-8 and 59-63, wherein The content of the polyphenol-based component (1) is selected from the following group, between about 10 g / ha and about 350 g / ha; between about 40 g / ha and about 90 g / ha; and Between 43.75g / ha and 87.5g / ha.

65. The multi-component combination of any one of claims 1-8 and 59-63, wherein When present, the content of the copper-based component (3) is selected from the group consisting of, Between about 1 g / ha and 350 g / ha of copper; and Between 5g / ha-50g / ha of copper.

66. The combination of any one of claims 1-8 and 59-63, wherein The polyphenol-based component is provided as a solid or liquid comprising any of 7.5%, 10%, 12.5%, 15%, 17.5%, 20%, 22.5%, 25%, 27.5%, 30%, 32.5%, 35%, 37.5%, 40%, 42.5% or 45% of a mixture of several water-soluble tannins and proanthocyanidins, preferably of natural origin.

67. The combination of any one of claims 1-8 and 59-63, wherein The polyphenol-based component is tannin and / or its derivatives, characterized in that the tannin and / or its derivatives include condensed tannins of the proanthocyanidin, prodelphinidin, protoacacetin or protofeiseridin type, and / or hydrolyzed tannins and / or brown algae polyphenols extracted from algae, or a mixture thereof.

68. A fungicidal multi-component composition based on tannins and / or their derivatives for treating cultivated plants and / or their parts and / or their growing sites, characterized in that The fungicidal multi-component composition comprises: a) a first component comprising tannins in at least one solvent, b) a second component comprising at least one systemic fungicide selected from the group consisting of QiI fungicides; strobilurin fungicides; SDHI fungicides; azole fungicides; morpholine fungicides and any and all mixtures of two or more thereof, The first and second components are mixed to form a solution or dispersion of the tannin and / or its derivatives and the at least one systemic fungicide in a solvent, the solution or dispersion being suitable for application to plants by spraying or dipping.

69. The composition of claim 68, wherein The amount of tannin in the first component used is selected from the group consisting of, between 0.1% and 75% by weight of the composition; and between 0.5% and 45% by weight of the composition of the first component.

70. The composition of claim 68, wherein The first component comprises at least one organic and / or inorganic salt comprising a cation of at least one substance or element, such as ammonium, potassium, phosphorus, calcium, molybdenum, iron, zinc, magnesium, manganese, copper, cobalt or boron (NH4, K, P, Ca, Mo, Fe, Zn, Mg, Mn, Cu, Co, B), or a combination thereof.

71. The composition of claim 70, wherein The salt comprises an organic or inorganic anion, and it is in the form of sulfate, chloride, nitrate, phosphate, carbonate, formate and / or acetate, or a combination thereof.

72. The composition of claim 26, comprising a combination in liquid form selected from the group consisting of, Mancozeb 400g / l, picoxystrobin 26.7g / l, tebuconazole 33g / l, polyphenols 22.5g / l; Mancozeb 300g / l, picoxystrobin 32.5g / l, tebuconazole 50g / l, polyphenols 45g / l; Mancozeb 300g / l, picoxystrobin 32.5g / l, tebuconazole 50g / l, polyphenols 22.5g / l; Mancozeb 300g / l, picoxystrobin 32.5g / l, tebuconazole 50g / l, copper 4g / l, polyphenols 45g / l; Mancozeb 300g / l, picoxystrobin 32.5g / l, tebuconazole 50g / l, copper 4g / l, polyphenols 22.5g / l; and Mancozeb 300g / l, picoxystrobin 32.5g / l, tebuconazole 50g / l, copper 25g / l, polyphenols 45g / l.

73. A multi-component combination as described in any one of claims 1-8 and 20-24, or a composition comprising said combination and an agriculturally acceptable carrier, wherein, The combination or composition comprises a reduced amount of between 10% and 50% of both component (2) fungicide (A) and component (3) protectant fungicide compound, compared to a fungicidally effective combination of the same component (2) fungicide (A) and component (3) protectant fungicide compound without the polyphenol-based component, characterized in that when applied, it exhibits comparable or equal fungicidal efficacy.

74. The multi-component combination and / or composition of claim 73, wherein: The combination or composition comprises a reduced amount of between 20% and 40% of both component (2) fungicide (A) and component (3) protectant fungicide, when compared to a fungicidally effective combination of the same component (2) fungicide (A) and component (3) protectant fungicide compounds without the polyphenol-based component, characterized in that it exhibits comparable or equal efficacy when applied.

75. A method of treating a plant or locus to resist fungal and / or bacterial infection, the method comprising applying to the plant or locus the composition of claim 72 to thereby treat the plant or locus to resist fungal and / or bacterial infection, wherein, The composition is administered at a ratio selected from the group consisting of, Mancozeb 720g / ha, picoxystrobin 48g / ha, tebuconazole 59.4g / ha, polyphenols 40.5g / ha; Mancozeb 800g / ha, picoxystrobin 53.3g / ha, tebuconazole 66g / ha, polyphenols 45g / ha; Mancozeb 880g / ha, picoxystrobin 58.7g / ha, tebuconazole 72.6g / ha, polyphenols 49.5g / ha; Mancozeb 600g / ha, picoxystrobin 65g / ha, tebuconazole 100g / ha, polyphenols 90g / ha; Mancozeb 600g / ha, picoxystrobin 65g / ha, tebuconazole 100g / ha, polyphenols 45g / ha; Mancozeb 600g / ha, picoxystrobin 65g / ha, tebuconazole 100g / ha, copper 8g / ha, polyphenols 90g / ha; Mancozeb 600g / ha, picoxystrobin 65g / ha, tebuconazole 100g / ha, copper 8g / ha, polyphenols 45g / ha; and Mancozeb 600g / ha, picoxystrobin 65g / ha, tebuconazole 100g / ha, copper 50g / ha, polyphenols 90g / ha.

76. A method for improved treatment of crop plants, the method comprising applying a combination as claimed in any one of claims 1 to 8, wherein The amount of polyphenol-based component (1) improves the beneficial effects of applying the amount of fungicide component (2) compared to when the same amount of the fungicide is not applied in combination with the amount of the polyphenol-based component, wherein the beneficial effects are selected from the group consisting of: improved emergence; improved crop yield; improved protein content; improved oil content; improved starch content; more developed root system and / or improved root growth; improved stress resistance and / or improved abiotic stress relief, including resistance to drought, heat, salt, UV, water or cold ; reduced ethylene, including reduced production and / or inhibited uptake; reduced phytotoxicity; increased plant height; larger leaves, less dead basal leaves; stronger tillers; greener leaf color; improved pigment content, improved photosynthetic activity; less fertilizer or water input required; fewer seeds required; more productive tillers, earlier flowering; earlier grain maturity, less plant segmentation or lodging; stem shortening; increased stem diameter; increased shoot growth; enhanced plant vigor; increased plant stand; earlier and better seedling emergence; and any and all combinations thereof.

77. The method of claim 75, comprising applying the composition such that the composition is applied at a rate of between about 10% and about 50% reduction in both the component (2) fungicide (A) compound and the component (3) protectant fungicide compound compared to a fungicidally effective application rate of the same combination of component (2) fungicide (A) and component (3) protectant fungicide compounds without the polyphenol-based component, wherein the method is characterized by exhibiting comparable or equal efficacy when applied.

78. A method for reducing the amount of systemic fungicide compounds and protectant fungicide compounds required for the fungicidal efficacy of a protectant fungicide and a systemic fungicide combination, the protectant fungicide being selected from the group consisting of fluazinam; thiophanate-methyl; mancozeb; sulphur; folpet; and captan, the systemic fungicide being selected from the group consisting of: a) QiI fungicides, b) strobilurin fungicides, c) succinate dehydrogenase inhibitor (SDHI) fungicides, d) triazole fungicides, and e) morpholine fungicides; and f) Any and all mixtures of two or more of (a) to (e), wherein the method comprises combining at least one polyphenol-based compound with the systemic fungicide, provided that the polyphenol-based compound comprises a naturally derived or derived polyphenol-based compound, and / or the polyphenol-based compound contains at least one polyphenol that is not a lignin sulfonate, and that lignin sulfonate, if present in the combination or in a composition comprising the combination, is not the only polyphenol-based compound.

Images